IMP: Integrative Multi-species Prediction

Danio rerio

10 known processes

cx52.6

connexin 52.6

ZFIN: ZDB-GENE-040310-6
Entrez: 404207
Ensembl: ENSDARG00000034930
UniProtKB: Q8JHW1
UniProtKB: E7F3P4

Process Predictions
Disease Predictions

cx52.6 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

Filter by process size:

Biological process	GO term ID	Process size	Probability	Func Analog Org
positive regulation of cellular process	GO:0048522	201	0.427
response to stress	GO:0006950	263	0.277	Zebrafish
embryonic organ development	GO:0048568	381	0.256	Zebrafish
immune system process	GO:0002376	241	0.219	Zebrafish
signal transduction	GO:0007165	455	0.210
regulation of primary metabolic process	GO:0080090	311	0.205
aromatic compound biosynthetic process	GO:0019438	217	0.193
response to chemical	GO:0042221	320	0.181
cell projection organization	GO:0030030	284	0.176
positive regulation of biological process	GO:0048518	253	0.174
brain development	GO:0007420	293	0.173
skeletal system development	GO:0001501	181	0.173	Zebrafish
regulation of metabolic process	GO:0019222	359	0.164
response to external stimulus	GO:0009605	264	0.162
single organism metabolic process	GO:0044710	217	0.158
cognition	GO:0050890	1	0.158
retina development in camera type eye	GO:0060041	146	0.152
homeostatic process	GO:0042592	142	0.149
organic cyclic compound metabolic process	GO:1901360	301	0.149
heterocycle metabolic process	GO:0046483	290	0.148
cellular macromolecule metabolic process	GO:0044260	391	0.148
head development	GO:0060322	303	0.143
organic cyclic compound biosynthetic process	GO:1901362	223	0.137
negative regulation of biological process	GO:0048519	304	0.136
single organism organelle organization	GO:1902589	199	0.130	Zebrafish
regulation of response to stimulus	GO:0048583	269	0.112
ribonucleotide biosynthetic process	GO:0009260	20	0.112
ion transmembrane transport	GO:0034220	91	0.111	Zebrafish
camera type eye development	GO:0043010	222	0.111
ion transport	GO:0006811	114	0.110	Zebrafish
negative regulation of cellular process	GO:0048523	283	0.109
cellular biosynthetic process	GO:0044249	286	0.106
aging	GO:0007568	2	0.105
generation of neurons	GO:0048699	385	0.103
biosynthetic process	GO:0009058	294	0.100
organic substance biosynthetic process	GO:1901576	289	0.100
eye development	GO:0001654	277	0.100
regulation of lyase activity	GO:0051339	12	0.098
embryo development ending in birth or egg hatching	GO:0009792	271	0.097	Zebrafish
gene expression	GO:0010467	252	0.097
taxis	GO:0042330	109	0.097
cellular aromatic compound metabolic process	GO:0006725	295	0.095
neurotransmitter transport	GO:0006836	2	0.095
angiogenesis	GO:0001525	158	0.092
response to light stimulus	GO:0009416	46	0.089
muscle cell differentiation	GO:0042692	139	0.088	Zebrafish
regulation of nucleobase containing compound metabolic process	GO:0019219	250	0.087
locomotion	GO:0040011	313	0.086
regulation of cellular metabolic process	GO:0031323	320	0.084
blood vessel morphogenesis	GO:0048514	216	0.083
sensory organ development	GO:0007423	393	0.082	Zebrafish
g protein coupled receptor signaling pathway	GO:0007186	74	0.080
rna metabolic process	GO:0016070	219	0.079
phosphorus metabolic process	GO:0006793	109	0.078
nucleic acid metabolic process	GO:0090304	244	0.078
regulation of nitrogen compound metabolic process	GO:0051171	251	0.077
regulation of biological quality	GO:0065008	263	0.075
establishment of localization in cell	GO:0051649	77	0.074
nucleobase containing compound biosynthetic process	GO:0034654	205	0.071
sensory organ morphogenesis	GO:0090596	200	0.069
regulation of biosynthetic process	GO:0009889	250	0.066
transcription dna templated	GO:0006351	181	0.065
single organism transport	GO:0044765	206	0.064
regulation of gene expression	GO:0010468	265	0.063
neuron development	GO:0048666	262	0.062
cellular component morphogenesis	GO:0032989	336	0.062	Zebrafish
neuron differentiation	GO:0030182	353	0.062
cellular macromolecule biosynthetic process	GO:0034645	224	0.061
regulation of nucleic acid templated transcription	GO:1903506	213	0.061
purine containing compound metabolic process	GO:0072521	29	0.059
cellular response to radiation	GO:0071478	4	0.059
regulation of cell development	GO:0060284	100	0.057
localization of cell	GO:0051674	244	0.057
central nervous system development	GO:0007417	387	0.057
kupffer s vesicle development	GO:0070121	50	0.055	Zebrafish
regulation of cellular biosynthetic process	GO:0031326	245	0.054
cellular component movement	GO:0006928	335	0.053
death	GO:0016265	121	0.052
cell part morphogenesis	GO:0032990	246	0.051
nucleobase containing compound metabolic process	GO:0006139	274	0.051
phosphate containing compound metabolic process	GO:0006796	108	0.050
regulation of rna biosynthetic process	GO:2001141	213	0.050
adenylate cyclase modulating g protein coupled receptor signaling pathway	GO:0007188	5	0.050
cellular protein metabolic process	GO:0044267	129	0.049
stem cell proliferation	GO:0072089	4	0.049
vasculature development	GO:0001944	278	0.047
blood vessel development	GO:0001568	246	0.046
phospholipase c activating g protein coupled receptor signaling pathway	GO:0007200	2	0.043
negative regulation of response to stimulus	GO:0048585	104	0.042
forebrain development	GO:0030900	96	0.041
regulation of transcription dna templated	GO:0006355	213	0.040
photoreceptor cell differentiation	GO:0046530	55	0.039
transport	GO:0006810	220	0.038
eye morphogenesis	GO:0048592	144	0.038
cyclic nucleotide metabolic process	GO:0009187	18	0.038
rna biosynthetic process	GO:0032774	181	0.038
embryonic skeletal joint development	GO:0072498	3	0.037	Zebrafish
embryonic cranial skeleton morphogenesis	GO:0048701	90	0.037
regulation of signaling	GO:0023051	235	0.035
negative regulation of innate immune response	GO:0045824	2	0.035
response to uv	GO:0009411	3	0.035
heterocycle biosynthetic process	GO:0018130	215	0.035
neural crest cell differentiation	GO:0014033	72	0.035
macromolecule biosynthetic process	GO:0009059	227	0.035
cellular response to unfolded protein	GO:0034620	2	0.034
regulation of circadian rhythm	GO:0042752	4	0.034
cellular nitrogen compound metabolic process	GO:0034641	290	0.033
regulation of localization	GO:0032879	104	0.033	Zebrafish
fin development	GO:0033333	77	0.033	Zebrafish
cell surface receptor signaling pathway	GO:0007166	325	0.033
maintenance of location	GO:0051235	4	0.033
negative regulation of protein kinase activity	GO:0006469	4	0.032
chemical homeostasis	GO:0048878	49	0.032
response to wounding	GO:0009611	116	0.032	Zebrafish
system process	GO:0003008	185	0.032	Zebrafish
multicellular organismal response to stress	GO:0033555	2	0.031
metal ion homeostasis	GO:0055065	26	0.031
locomotor rhythm	GO:0045475	3	0.030
wound healing	GO:0042060	90	0.030	Zebrafish
nucleoside phosphate metabolic process	GO:0006753	28	0.030
purine ribonucleotide biosynthetic process	GO:0009152	20	0.030
regulation of cell communication	GO:0010646	232	0.030
regulation of transmembrane transport	GO:0034762	18	0.030	Zebrafish
embryonic skeletal system development	GO:0048706	97	0.029	Zebrafish
nucleobase containing small molecule metabolic process	GO:0055086	32	0.029
phototransduction	GO:0007602	2	0.029
regulation of multicellular organismal process	GO:0051239	277	0.029
positive regulation of transport	GO:0051050	2	0.029
regulation of sequestering of calcium ion	GO:0051282	4	0.028
regulation of rna metabolic process	GO:0051252	224	0.028
negative regulation of signaling	GO:0023057	96	0.028
detection of external stimulus	GO:0009581	24	0.027
regulation of cyclase activity	GO:0031279	12	0.027
lipid storage	GO:0019915	1	0.027
organonitrogen compound metabolic process	GO:1901564	74	0.027
neuron projection development	GO:0031175	180	0.027
g protein coupled receptor signaling pathway coupled to cyclic nucleotide second messenger	GO:0007187	5	0.027
regulation of molecular function	GO:0065009	70	0.027
response to metal ion	GO:0010038	34	0.026
epithelial cell differentiation	GO:0030855	116	0.026
neural crest cell development	GO:0014032	62	0.026
endoplasmic reticulum unfolded protein response	GO:0030968	2	0.025
detection of visible light	GO:0009584	12	0.025
positive regulation of multicellular organismal process	GO:0051240	52	0.025
sensory perception	GO:0007600	39	0.025	Zebrafish
larval development	GO:0002164	2	0.025
small molecule metabolic process	GO:0044281	77	0.024
sequestering of metal ion	GO:0051238	3	0.024
response to radiation	GO:0009314	51	0.024
transmembrane transport	GO:0055085	120	0.024
axonogenesis	GO:0007409	152	0.024
cellular component assembly	GO:0022607	170	0.024	Zebrafish
embryonic skeletal system morphogenesis	GO:0048704	93	0.024	Zebrafish
nitrogen compound metabolic process	GO:0006807	319	0.023
sequestering of calcium ion	GO:0051208	3	0.023
negative regulation of kinase activity	GO:0033673	4	0.023
cellular amine metabolic process	GO:0044106	2	0.023
positive regulation of somitomeric trunk muscle development	GO:0014709	1	0.023
purine nucleotide metabolic process	GO:0006163	27	0.023
positive regulation of cellular component biogenesis	GO:0044089	3	0.023
cellular localization	GO:0051641	97	0.023
nucleic acid templated transcription	GO:0097659	181	0.023
response to corticosteroid	GO:0031960	1	0.022
fertilization	GO:0009566	3	0.022
embryonic organ morphogenesis	GO:0048562	274	0.022	Zebrafish
cell morphogenesis involved in neuron differentiation	GO:0048667	163	0.022
cell morphogenesis	GO:0000902	289	0.022
positive regulation of cellular catabolic process	GO:0031331	3	0.022
ribose phosphate biosynthetic process	GO:0046390	20	0.022
response to abiotic stimulus	GO:0009628	122	0.022
positive regulation of alcohol biosynthetic process	GO:1902932	1	0.022
internal protein amino acid acetylation	GO:0006475	2	0.022
regulation of macromolecule metabolic process	GO:0060255	317	0.022
negative regulation of metabolic process	GO:0009892	86	0.021
pigmentation	GO:0043473	85	0.021	Zebrafish
organophosphate metabolic process	GO:0019637	37	0.021
embryonic camera type eye development	GO:0031076	29	0.021
organophosphate biosynthetic process	GO:0090407	23	0.021
mechanosensory behavior	GO:0007638	2	0.021
determination of bilateral symmetry	GO:0009855	204	0.021
mesenchymal cell differentiation	GO:0048762	87	0.021
photoreceptor cell outer segment organization	GO:0035845	9	0.020
hormone secretion	GO:0046879	2	0.020
cytoskeleton organization	GO:0007010	96	0.020	Zebrafish
carbohydrate derivative metabolic process	GO:1901135	61	0.020
neuron projection morphogenesis	GO:0048812	161	0.020
detection of light stimulus	GO:0009583	12	0.020
sensory perception of chemical stimulus	GO:0007606	3	0.020
cation transmembrane transport	GO:0098655	65	0.019
cellular ketone metabolic process	GO:0042180	11	0.019
negative regulation of macromolecule metabolic process	GO:0010605	76	0.019
positive regulation of catabolic process	GO:0009896	4	0.019
calcium ion dependent exocytosis	GO:0017156	1	0.019
er nucleus signaling pathway	GO:0006984	2	0.019
mesenchyme development	GO:0060485	127	0.019
chordate embryonic development	GO:0043009	271	0.019	Zebrafish
response to unfolded protein	GO:0006986	2	0.019
cell motility	GO:0048870	244	0.019
organelle organization	GO:0006996	227	0.019	Zebrafish
intracellular signal transduction	GO:0035556	85	0.019
regulation of locomotion	GO:0040012	55	0.019
gland development	GO:0048732	143	0.019
regulation of signal transduction	GO:0009966	225	0.018
regulation of stem cell proliferation	GO:0072091	2	0.018
adult behavior	GO:0030534	2	0.018
developmental growth	GO:0048589	166	0.018	Zebrafish
regulation of phosphorus metabolic process	GO:0051174	43	0.018
ribonucleotide metabolic process	GO:0009259	27	0.017
negative regulation of nucleobase containing compound metabolic process	GO:0045934	59	0.017
cyclic nucleotide biosynthetic process	GO:0009190	18	0.017
skeletal muscle tissue development	GO:0007519	67	0.017
appendage morphogenesis	GO:0035107	56	0.017	Zebrafish
cation homeostasis	GO:0055080	33	0.017
establishment of protein localization to organelle	GO:0072594	4	0.017
tissue regeneration	GO:0042246	74	0.017	Zebrafish
organonitrogen compound biosynthetic process	GO:1901566	47	0.017
regulation of nervous system development	GO:0051960	90	0.017
protein acylation	GO:0043543	3	0.016
regulation of hormone secretion	GO:0046883	2	0.016
skeletal system morphogenesis	GO:0048705	102	0.016	Zebrafish
protein acetylation	GO:0006473	2	0.016
negative regulation of hormone secretion	GO:0046888	2	0.016
positive regulation of stem cell proliferation	GO:2000648	1	0.016
peptidyl lysine acetylation	GO:0018394	2	0.016
negative regulation of mitosis	GO:0045839	3	0.016
single organism behavior	GO:0044708	24	0.016
hypochord development	GO:0055016	3	0.016
regulation of ion transmembrane transport	GO:0034765	18	0.016	Zebrafish
endocrine system development	GO:0035270	65	0.016
monoamine transport	GO:0015844	1	0.016
negative regulation of developmental process	GO:0051093	65	0.016
regeneration	GO:0031099	91	0.016	Zebrafish
peptide transport	GO:0015833	1	0.016
regulation of cellular amine metabolic process	GO:0033238	0	0.015
regulation of ion transport	GO:0043269	22	0.015	Zebrafish
meiotic nuclear division	GO:0007126	4	0.015
chemosensory behavior	GO:0007635	1	0.015
regulation of multicellular organism growth	GO:0040014	4	0.015
gtp metabolic process	GO:0046039	4	0.015
regulation of cellular macromolecule biosynthetic process	GO:2000112	222	0.015
regulation of cell activation	GO:0050865	1	0.015
regulation of circadian sleep wake cycle	GO:0042749	1	0.015
regulation of calcium ion dependent exocytosis	GO:0017158	1	0.015
positive regulation of protein complex assembly	GO:0031334	2	0.015
striated muscle cell differentiation	GO:0051146	129	0.015	Zebrafish
cellular protein catabolic process	GO:0044257	4	0.015
single organism localization	GO:1902578	225	0.015
proteasome mediated ubiquitin dependent protein catabolic process	GO:0043161	2	0.015
exocytosis	GO:0006887	1	0.015
regulation of receptor activity	GO:0010469	2	0.015
regulation of catalytic activity	GO:0050790	55	0.014
cellular response to nutrient levels	GO:0031669	2	0.014
regulation of neuron differentiation	GO:0045664	56	0.014
neurotransmitter secretion	GO:0007269	2	0.014
circadian regulation of gene expression	GO:0032922	8	0.014
axon development	GO:0061564	166	0.014
cell migration	GO:0016477	237	0.014
cell cell recognition	GO:0009988	1	0.014
establishment of localization	GO:0051234	244	0.014
digestive tract development	GO:0048565	265	0.014
detection of abiotic stimulus	GO:0009582	24	0.014
cell death	GO:0008219	121	0.014
ion homeostasis	GO:0050801	41	0.014
mitochondrion organization	GO:0007005	4	0.014
cellular response to chemical stimulus	GO:0070887	157	0.014
stem cell maintenance	GO:0019827	4	0.014
regulation of cyclic nucleotide biosynthetic process	GO:0030802	15	0.014
internal peptidyl lysine acetylation	GO:0018393	2	0.014
cellular response to extracellular stimulus	GO:0031668	2	0.014
blood circulation	GO:0008015	87	0.014
muscle tissue development	GO:0060537	110	0.014	Zebrafish
cyclic purine nucleotide metabolic process	GO:0052652	18	0.014
purine containing compound biosynthetic process	GO:0072522	20	0.014
transcription from rna polymerase ii promoter	GO:0006366	80	0.013
negative regulation of signal transduction	GO:0009968	94	0.013
negative regulation of biosynthetic process	GO:0009890	55	0.013
negative regulation of cellular metabolic process	GO:0031324	77	0.013
transmission of nerve impulse	GO:0019226	19	0.013
regulation of transport	GO:0051049	45	0.013	Zebrafish
response to food	GO:0032094	1	0.013
macromolecule modification	GO:0043412	111	0.013
digestive tract morphogenesis	GO:0048546	231	0.013
growth	GO:0040007	174	0.013	Zebrafish
regulation of cellular carbohydrate metabolic process	GO:0010675	4	0.013
detection of stimulus	GO:0051606	29	0.013
gtp catabolic process	GO:0006184	2	0.013
negative regulation of sequestering of calcium ion	GO:0051283	4	0.013
cell morphogenesis involved in differentiation	GO:0000904	195	0.013
digestive system development	GO:0055123	289	0.013
regulation of transporter activity	GO:0032409	2	0.013
regulation of developmental process	GO:0050793	247	0.013
stem cell differentiation	GO:0048863	117	0.013
regulation of nucleoside metabolic process	GO:0009118	2	0.012
behavior	GO:0007610	74	0.012
negative regulation of nuclear division	GO:0051784	3	0.012
neurological system process	GO:0050877	62	0.012	Zebrafish
chemotaxis	GO:0006935	104	0.012
muscle cell development	GO:0055001	115	0.012	Zebrafish
regulation of cell differentiation	GO:0045595	142	0.012
regulation of camp biosynthetic process	GO:0030817	9	0.012
alcohol biosynthetic process	GO:0046165	2	0.012
organic substance transport	GO:0071702	58	0.012
regulation of reproductive process	GO:2000241	4	0.012
regulation of protein metabolic process	GO:0051246	56	0.012
regulation of transferase activity	GO:0051338	16	0.012
regulation of dendrite morphogenesis	GO:0048814	3	0.012
response to organic substance	GO:0010033	153	0.012
proteasomal protein catabolic process	GO:0010498	2	0.012
diencephalon development	GO:0021536	58	0.012
organic acid metabolic process	GO:0006082	31	0.012
embryonic eye morphogenesis	GO:0048048	30	0.012
locomotory behavior	GO:0007626	34	0.012
response to topologically incorrect protein	GO:0035966	2	0.012
rhodopsin mediated signaling pathway	GO:0016056	1	0.011
establishment of cell polarity	GO:0030010	18	0.011
regulation of ion transmembrane transporter activity	GO:0032412	2	0.011
proteolysis involved in cellular protein catabolic process	GO:0051603	3	0.011
cell cycle checkpoint	GO:0000075	7	0.011
regionalization	GO:0003002	274	0.011
regulation of macromolecule biosynthetic process	GO:0010556	225	0.011
negative regulation of secretion	GO:0051048	2	0.011
positive regulation of macromolecule metabolic process	GO:0010604	93	0.011
negative regulation of defense response	GO:0031348	2	0.011
modification dependent protein catabolic process	GO:0019941	3	0.011
regulation of cellular protein metabolic process	GO:0032268	52	0.011
multicellular organismal signaling	GO:0035637	22	0.011
embryonic skeletal joint morphogenesis	GO:0060272	3	0.011	Zebrafish
negative regulation of catalytic activity	GO:0043086	21	0.011
organelle assembly	GO:0070925	110	0.011	Zebrafish
negative regulation of secretion by cell	GO:1903531	2	0.011
regulation of response to external stimulus	GO:0032101	31	0.011
regulation of stem cell differentiation	GO:2000736	4	0.011
negative regulation of feeding behavior	GO:2000252	2	0.011
cellular response to light stimulus	GO:0071482	4	0.011
regulation of cell death	GO:0010941	103	0.011
regulation of cellular component movement	GO:0051270	55	0.010
regulation of nucleotide biosynthetic process	GO:0030808	15	0.010
positive regulation of nucleic acid templated transcription	GO:1903508	57	0.010
myofibril assembly	GO:0030239	48	0.010	Zebrafish
positive regulation of cellular metabolic process	GO:0031325	94	0.010
mesenchymal cell development	GO:0014031	78	0.010
ubiquitin dependent protein catabolic process	GO:0006511	3	0.010
skeletal muscle fiber development	GO:0048741	35	0.010
negative regulation of cyclase activity	GO:0031280	6	0.010
immune response	GO:0006955	28	0.010

cx52.6 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease	DO term ID	Probability
disease of metabolism	DOID:0014667	0.053
disease of anatomical entity	DOID:7	0.024
inherited metabolic disorder	DOID:655	0.010

Loading network...

Network Filters

Minimum relationship confidence:

Maximum number of genes:

Highlight known relationships in gold.

Graphical Options

Adjust edge length:

Adjust node size:

Fixed layout

Black background

Low confidence color:

Med confidence color:

High confidence color:

Hide the legend in the network