IMP: Integrative Multi-species Prediction

Danio rerio

9 known processes

sumo1

SMT3 suppressor of mif two 3 homolog 1 (yeast)

(Aliases: zgc:85634,wu:fd12c02,zgc:65934,wu:fb74c02,hm:zeh0670)

ZFIN: ZDB-GENE-040426-2186
Entrez: 406438
Ensembl: ENSDARG00000044267
UniProtKB: Q7SZR5

Process Predictions
Disease Predictions

sumo1 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
cell part morphogenesis	GO:0032990	246	0.341
positive regulation of cellular process	GO:0048522	201	0.320	Human Mouse
protein desumoylation	GO:0016926	1	0.313
neuron projection development	GO:0031175	180	0.291
cellular respiration	GO:0045333	3	0.290
modification dependent macromolecule catabolic process	GO:0043632	3	0.264	Human
cell morphogenesis involved in neuron differentiation	GO:0048667	163	0.254
cellular component movement	GO:0006928	335	0.252	Mouse
cell morphogenesis involved in differentiation	GO:0000904	195	0.241
regulation of nucleic acid templated transcription	GO:1903506	213	0.239	Human Mouse Worm
protein targeting to nucleus	GO:0044744	3	0.237
mitotic cell cycle embryonic	GO:0045448	2	0.220
cell projection organization	GO:0030030	284	0.215
establishment of localization	GO:0051234	244	0.209	Mouse
localization of cell	GO:0051674	244	0.196
nucleobase containing compound metabolic process	GO:0006139	274	0.193	Human Mouse Worm
single organism nuclear import	GO:1902593	3	0.189
cell migration	GO:0016477	237	0.185
lipid homeostasis	GO:0055088	3	0.168
transcription dna templated	GO:0006351	181	0.162	Human Mouse Worm
nuclear transport	GO:0051169	4	0.153
cellular protein catabolic process	GO:0044257	4	0.151	Human
protein localization to nucleus	GO:0034504	3	0.151	Mouse
regulation of primary metabolic process	GO:0080090	311	0.149	Human Mouse Worm
regulation of cellular metabolic process	GO:0031323	320	0.145	Human Mouse Worm
modification dependent protein catabolic process	GO:0019941	3	0.144	Human
protein sumoylation	GO:0016925	2	0.143	Human Mouse
gene expression	GO:0010467	252	0.138	Human Mouse Worm
cell motility	GO:0048870	244	0.136
extrinsic apoptotic signaling pathway	GO:0097191	3	0.135
protein metabolic process	GO:0019538	183	0.130	Human Mouse
regulation of macromolecule metabolic process	GO:0060255	317	0.127	Human Mouse Worm
neuron development	GO:0048666	262	0.127
positive regulation of biological process	GO:0048518	253	0.125	Human Mouse
neuron projection morphogenesis	GO:0048812	161	0.124
single organism transport	GO:0044765	206	0.122	Mouse
morphogenesis of an epithelium	GO:0002009	333	0.122
regulation of signaling	GO:0023051	235	0.122
protein import into nucleus	GO:0006606	3	0.121
central nervous system neuron differentiation	GO:0021953	74	0.119
regulation of metabolic process	GO:0019222	359	0.118	Human Mouse Worm
nucleocytoplasmic transport	GO:0006913	4	0.113
positive regulation of metabolic process	GO:0009893	108	0.111	Human Mouse
regulation of protein modification by small protein conjugation or removal	GO:1903320	3	0.110
central nervous system development	GO:0007417	387	0.109
positive regulation of map kinase activity	GO:0043406	3	0.105
ubiquitin dependent protein catabolic process	GO:0006511	3	0.104	Human
protein import	GO:0017038	3	0.097
energy derivation by oxidation of organic compounds	GO:0015980	5	0.097
anterior posterior pattern specification	GO:0009952	152	0.097
central nervous system neuron axonogenesis	GO:0021955	18	0.096
establishment of protein localization to organelle	GO:0072594	4	0.096
small gtpase mediated signal transduction	GO:0007264	8	0.095
regulation of cellular biosynthetic process	GO:0031326	245	0.088	Human Mouse Worm
regulation of cell communication	GO:0010646	232	0.087
generation of neurons	GO:0048699	385	0.087
cellular macromolecule metabolic process	GO:0044260	391	0.086	Human Mouse Worm
nuclear import	GO:0051170	3	0.086
cellular response to organic substance	GO:0071310	105	0.086
cellular response to chemical stimulus	GO:0070887	157	0.085
regionalization	GO:0003002	274	0.084
eye development	GO:0001654	277	0.083
central nervous system projection neuron axonogenesis	GO:0021952	15	0.083
axon development	GO:0061564	166	0.082
cell morphogenesis	GO:0000902	289	0.080
regulation of protein ubiquitination	GO:0031396	3	0.079
cell projection morphogenesis	GO:0048858	244	0.079
microtubule based process	GO:0007017	60	0.076
mitotic cell cycle	GO:0000278	64	0.076
multi organism process	GO:0051704	134	0.075
protein polyubiquitination	GO:0000209	4	0.075
regulation of cell death	GO:0010941	103	0.073
rna metabolic process	GO:0016070	219	0.073	Human Mouse Worm
positive regulation of transport	GO:0051050	2	0.071	Mouse
ameboidal type cell migration	GO:0001667	143	0.070
regulation of rna biosynthetic process	GO:2001141	213	0.070	Human Mouse Worm
cell cycle	GO:0007049	93	0.069
enzyme linked receptor protein signaling pathway	GO:0007167	106	0.067
protein modification process	GO:0036211	100	0.066	Human Mouse
sympathetic nervous system development	GO:0048485	3	0.066
heart development	GO:0007507	313	0.065
cellular aromatic compound metabolic process	GO:0006725	295	0.065	Human Mouse Worm
peptide transport	GO:0015833	1	0.064
single organism organelle organization	GO:1902589	199	0.064	Worm
positive regulation of cellular metabolic process	GO:0031325	94	0.063	Human Mouse
regulation of apoptotic process	GO:0042981	98	0.061
transport	GO:0006810	220	0.061	Mouse
central nervous system neuron development	GO:0021954	29	0.061
regulation of biosynthetic process	GO:0009889	250	0.061	Human Mouse Worm
organic cyclic compound metabolic process	GO:1901360	301	0.060	Human Mouse Worm
regulation of signal transduction	GO:0009966	225	0.059
embryonic limb morphogenesis	GO:0030326	2	0.058
organelle organization	GO:0006996	227	0.057	Mouse Worm
positive regulation of small gtpase mediated signal transduction	GO:0051057	1	0.056
signal transduction	GO:0007165	455	0.056
aging	GO:0007568	2	0.055
mitotic dna integrity checkpoint	GO:0044774	4	0.055
cellular carbohydrate metabolic process	GO:0044262	4	0.054
response to chemical	GO:0042221	320	0.054
response to uv	GO:0009411	3	0.054
regulation of binding	GO:0051098	3	0.054	Human
sensory organ development	GO:0007423	393	0.054
death	GO:0016265	121	0.054
proteasome mediated ubiquitin dependent protein catabolic process	GO:0043161	2	0.053	Human
regulation of phosphate metabolic process	GO:0019220	43	0.053	Mouse
regulation of macromolecule biosynthetic process	GO:0010556	225	0.053	Human Mouse Worm
ras protein signal transduction	GO:0007265	7	0.052
cellular protein metabolic process	GO:0044267	129	0.052	Human Mouse
single organism localization	GO:1902578	225	0.052	Mouse
regulation of meiotic cell cycle	GO:0051445	1	0.052
positive regulation of cell cycle	GO:0045787	3	0.051
embryonic organ development	GO:0048568	381	0.051
programmed cell death	GO:0012501	119	0.051
stem cell differentiation	GO:0048863	117	0.050
cellular macromolecule biosynthetic process	GO:0034645	224	0.049	Human Mouse Worm
response to organic substance	GO:0010033	153	0.048
positive regulation of signaling	GO:0023056	56	0.047
epidermal cell fate specification	GO:0009957	4	0.047
nucleobase containing compound biosynthetic process	GO:0034654	205	0.047	Human Mouse Worm
mitotic dna damage checkpoint	GO:0044773	4	0.046
neural crest cell migration	GO:0001755	42	0.046
intracellular signal transduction	GO:0035556	85	0.046
neuron differentiation	GO:0030182	353	0.045
nitrogen compound metabolic process	GO:0006807	319	0.045	Human Mouse Worm
regulation of nucleobase containing compound metabolic process	GO:0019219	250	0.045	Human Mouse Worm
positive regulation of protein complex assembly	GO:0031334	2	0.045	Human
stem cell development	GO:0048864	82	0.044
proteolysis involved in cellular protein catabolic process	GO:0051603	3	0.044	Human
neural crest cell development	GO:0014032	62	0.044
positive regulation of cellular protein metabolic process	GO:0032270	22	0.043	Human
cellular protein modification process	GO:0006464	100	0.043	Human Mouse
proteasomal protein catabolic process	GO:0010498	2	0.043	Human
response to external stimulus	GO:0009605	264	0.043
apoptotic process	GO:0006915	116	0.042
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	48	0.042	Human Worm
positive regulation of nitrogen compound metabolic process	GO:0051173	69	0.042	Mouse
cellular nitrogen compound biosynthetic process	GO:0044271	218	0.041	Human Mouse Worm
regulation of extrinsic apoptotic signaling pathway	GO:2001236	3	0.040
protein modification by small protein removal	GO:0070646	1	0.040
embryonic organ morphogenesis	GO:0048562	274	0.040
meiotic nuclear division	GO:0007126	4	0.040
phagocytosis	GO:0006909	3	0.039
response to stress	GO:0006950	263	0.039
positive regulation of signal transduction	GO:0009967	56	0.038
response to other organism	GO:0051707	97	0.038
response to endogenous stimulus	GO:0009719	83	0.038
regulation of programmed cell death	GO:0043067	101	0.038
cellular localization	GO:0051641	97	0.038	Mouse Worm
positive regulation of cellular catabolic process	GO:0031331	3	0.037	Human Mouse
mesenchyme development	GO:0060485	127	0.037
forebrain cell migration	GO:0021885	1	0.037
cellular response to nutrient levels	GO:0031669	2	0.036
cell surface receptor signaling pathway	GO:0007166	325	0.036
mitotic cell cycle process	GO:1903047	48	0.036
gastrulation	GO:0007369	208	0.036
positive regulation of ras protein signal transduction	GO:0046579	1	0.036
protein acylation	GO:0043543	3	0.035
mesenchymal cell development	GO:0014031	78	0.034
nucleic acid templated transcription	GO:0097659	181	0.034	Human Mouse Worm
positive regulation of cellular biosynthetic process	GO:0031328	68	0.034
cell cycle g1 s phase transition	GO:0044843	1	0.033
recombinational repair	GO:0000725	1	0.033
cellular response to endogenous stimulus	GO:0071495	68	0.032
ear development	GO:0043583	127	0.032
digestive tract morphogenesis	GO:0048546	231	0.032
camera type eye development	GO:0043010	222	0.031
heterocycle biosynthetic process	GO:0018130	215	0.031	Human Mouse Worm
digestive system development	GO:0055123	289	0.031
establishment of localization in cell	GO:0051649	77	0.030
chordate embryonic development	GO:0043009	271	0.030
negative regulation of cellular process	GO:0048523	283	0.030	Human Worm
organic acid metabolic process	GO:0006082	31	0.029
macromolecule modification	GO:0043412	111	0.029	Human Mouse
regulation of response to stimulus	GO:0048583	269	0.029
nucleic acid metabolic process	GO:0090304	244	0.028	Human Mouse Worm
macromolecular complex subunit organization	GO:0043933	74	0.028	Human
positive regulation of secretion	GO:0051047	1	0.027
positive regulation of cell death	GO:0010942	29	0.027
embryo development ending in birth or egg hatching	GO:0009792	271	0.027	Worm
regulation of gene expression	GO:0010468	265	0.027	Human Mouse Worm
negative regulation of programmed cell death	GO:0043069	58	0.027
head development	GO:0060322	303	0.027
skeletal muscle organ development	GO:0060538	78	0.026
locomotion	GO:0040011	313	0.026
cellular response to stress	GO:0033554	62	0.026
regulation of cell differentiation	GO:0045595	142	0.026
extrinsic apoptotic signaling pathway in absence of ligand	GO:0097192	1	0.026
heart morphogenesis	GO:0003007	156	0.026
carboxylic acid metabolic process	GO:0019752	22	0.025
regulation of cell proliferation	GO:0042127	37	0.025
retina development in camera type eye	GO:0060041	146	0.025
cellular nitrogen compound metabolic process	GO:0034641	290	0.025	Human Mouse Worm
oxidation reduction process	GO:0055114	41	0.025
cytokinetic process	GO:0032506	2	0.025
regulation of cellular protein catabolic process	GO:1903362	1	0.025	Human
larval development	GO:0002164	2	0.025	Worm
striated muscle tissue development	GO:0014706	110	0.025
transcription from rna polymerase ii promoter	GO:0006366	80	0.025	Worm
double strand break repair via homologous recombination	GO:0000724	1	0.025
muscle tissue development	GO:0060537	110	0.024
vascular endothelial growth factor signaling pathway	GO:0038084	3	0.024
post embryonic morphogenesis	GO:0009886	4	0.024
cellular component biogenesis	GO:0044085	178	0.023	Human
apoptotic signaling pathway	GO:0097190	23	0.023
cytokinesis	GO:0000910	3	0.022
cellular response to external stimulus	GO:0071496	2	0.022
biosynthetic process	GO:0009058	294	0.022	Human Mouse Worm
regulation of carbohydrate metabolic process	GO:0006109	4	0.022
regulation of reproductive process	GO:2000241	4	0.021
midbrain development	GO:0030901	28	0.021
cellular component morphogenesis	GO:0032989	336	0.021
vesicle mediated transport	GO:0016192	22	0.021
axonogenesis	GO:0007409	152	0.021
regulation of wound healing	GO:0061041	2	0.021
somatic muscle development	GO:0007525	4	0.020
positive regulation of apoptotic signaling pathway	GO:2001235	1	0.020
cellular response to extracellular stimulus	GO:0031668	2	0.020
chemotaxis	GO:0006935	104	0.020
positive regulation of protein metabolic process	GO:0051247	23	0.019	Human
chromatin modification	GO:0016568	21	0.019
cell cycle process	GO:0022402	53	0.019
regulation of localization	GO:0032879	104	0.019	Mouse
glucose homeostasis	GO:0042593	1	0.019
pancreas development	GO:0031016	84	0.019
nuclear division	GO:0000280	23	0.019
lipid storage	GO:0019915	1	0.018
neural crest cell differentiation	GO:0014033	72	0.018
growth	GO:0040007	174	0.018
regulation of nitrogen compound metabolic process	GO:0051171	251	0.018	Human Mouse Worm
oxoacid metabolic process	GO:0043436	31	0.018
ribosomal small subunit biogenesis	GO:0042274	2	0.018
brain development	GO:0007420	293	0.017
negative regulation of cell death	GO:0060548	60	0.017
ribosome biogenesis	GO:0042254	9	0.017
chromosome organization	GO:0051276	31	0.017	Worm
maintenance of location	GO:0051235	4	0.017
regulation of cellular macromolecule biosynthetic process	GO:2000112	222	0.017	Human Mouse Worm
single organism metabolic process	GO:0044710	217	0.017	Mouse
response to growth factor	GO:0070848	39	0.017
negative regulation of catabolic process	GO:0009895	3	0.017
neurotransmitter secretion	GO:0007269	2	0.017
regulation of multicellular organismal development	GO:2000026	223	0.016	Worm
neuron migration	GO:0001764	22	0.016
adult behavior	GO:0030534	2	0.016
negative regulation of biosynthetic process	GO:0009890	55	0.016	Human Worm
cilium assembly	GO:0042384	58	0.016
regulation of transcription dna templated	GO:0006355	213	0.016	Human Mouse Worm
organic cyclic compound biosynthetic process	GO:1901362	223	0.016	Human Mouse Worm
positive regulation of catabolic process	GO:0009896	4	0.016	Human Mouse
positive regulation of multi organism process	GO:0043902	3	0.016
regulation of cellular amine metabolic process	GO:0033238	0	0.016
sensory neuron axon guidance	GO:0097374	3	0.015
regulation of multicellular organismal process	GO:0051239	277	0.015	Mouse Worm
translational initiation	GO:0006413	3	0.015
response to radiation	GO:0009314	51	0.015
internal protein amino acid acetylation	GO:0006475	2	0.015
sympathetic ganglion development	GO:0061549	2	0.015
muscle organ development	GO:0007517	101	0.015
positive regulation of myeloid cell differentiation	GO:0045639	2	0.015
brain morphogenesis	GO:0048854	18	0.015
generation of precursor metabolites and energy	GO:0006091	5	0.015
hematopoietic or lymphoid organ development	GO:0048534	191	0.015
positive regulation of erk1 and erk2 cascade	GO:0070374	2	0.015
cellular response to starvation	GO:0009267	1	0.014
positive regulation of secretion by cell	GO:1903532	1	0.014
meiotic cell cycle process	GO:1903046	3	0.014
regulation of molecular function	GO:0065009	70	0.014	Human Mouse
convergent extension	GO:0060026	118	0.014
positive regulation of cell communication	GO:0010647	56	0.014
cellular response to growth factor stimulus	GO:0071363	39	0.014
epidermis morphogenesis	GO:0048730	4	0.014
camera type eye morphogenesis	GO:0048593	108	0.014
regulation of protein modification process	GO:0031399	29	0.014
sequestering of metal ion	GO:0051238	3	0.014
cytoskeleton dependent cytokinesis	GO:0061640	3	0.014
appendage morphogenesis	GO:0035107	56	0.014
regulation of protein catabolic process	GO:0042176	1	0.014	Human
digestive tract development	GO:0048565	265	0.013
mitotic cytokinesis	GO:0000281	3	0.013
post embryonic organ development	GO:0048569	4	0.013	Worm
sensory system development	GO:0048880	76	0.013
eye morphogenesis	GO:0048592	144	0.013
single organism membrane fusion	GO:0044801	2	0.013
phosphate containing compound metabolic process	GO:0006796	108	0.013	Mouse
regulation of peptidyl tyrosine phosphorylation	GO:0050730	1	0.013
cellular protein localization	GO:0034613	20	0.013	Mouse Worm
histone modification	GO:0016570	20	0.013
amine metabolic process	GO:0009308	2	0.013
regulation of axonogenesis	GO:0050770	32	0.013
protein acetylation	GO:0006473	2	0.012
positive regulation of molecular function	GO:0044093	33	0.012	Mouse
cellular response to light stimulus	GO:0071482	4	0.012
regulation of hormone secretion	GO:0046883	2	0.012
cell death	GO:0008219	121	0.012
regeneration	GO:0031099	91	0.012
carbohydrate homeostasis	GO:0033500	1	0.012
mesenchymal cell differentiation	GO:0048762	87	0.012
macromolecule biosynthetic process	GO:0009059	227	0.012	Human Mouse Worm
reproduction	GO:0000003	40	0.012	Worm
regulation of cellular amino acid metabolic process	GO:0006521	0	0.012
regulation of cell cycle	GO:0051726	52	0.012
regulation of neurogenesis	GO:0050767	87	0.012
mitotic spindle organization	GO:0007052	5	0.012
mitotic g2 dna damage checkpoint	GO:0007095	3	0.012
cilium morphogenesis	GO:0060271	85	0.012
cellular biosynthetic process	GO:0044249	286	0.012	Human Mouse Worm
g1 s transition of mitotic cell cycle	GO:0000082	1	0.012
negative regulation of apoptotic process	GO:0043066	55	0.012
regulation of nervous system development	GO:0051960	90	0.012
regulation of chromosome segregation	GO:0051983	1	0.012
regulation of developmental process	GO:0050793	247	0.011	Worm
organic substance transport	GO:0071702	58	0.011
regulation of autophagy	GO:0010506	3	0.011
multicellular organism reproduction	GO:0032504	35	0.011
positive regulation of wound healing	GO:0090303	1	0.011
endocrine hormone secretion	GO:0060986	2	0.011
protein dephosphorylation	GO:0006470	3	0.011
immune system development	GO:0002520	191	0.011
dna biosynthetic process	GO:0071897	3	0.011
regulation of synaptic plasticity	GO:0048167	1	0.011
maturation of ssu rrna from tricistronic rrna transcript ssu rrna 5 8s rrna lsu rrna	GO:0000462	1	0.011
neural tube patterning	GO:0021532	33	0.011
protein k48 linked ubiquitination	GO:0070936	1	0.011
myotube differentiation	GO:0014902	45	0.011
negative regulation of histone modification	GO:0031057	1	0.011
urogenital system development	GO:0001655	97	0.011
proteolysis	GO:0006508	38	0.011	Human
regulation of cell activation	GO:0050865	1	0.011
regulation of embryonic development	GO:0045995	47	0.011
cranial ganglion development	GO:0061550	3	0.011
stem cell maintenance	GO:0019827	4	0.011
cellular response to radiation	GO:0071478	4	0.010
hormone transport	GO:0009914	2	0.010
defense response	GO:0006952	47	0.010
microtubule cytoskeleton organization	GO:0000226	33	0.010
fatty acid transport	GO:0015908	1	0.010
positive regulation of apoptotic process	GO:0043065	29	0.010
protein modification by small protein conjugation or removal	GO:0070647	14	0.010	Human Mouse
acylglycerol homeostasis	GO:0055090	2	0.010
regulation of dendrite development	GO:0050773	3	0.010
regulation of postsynaptic membrane potential	GO:0060078	1	0.010
response to light stimulus	GO:0009416	46	0.010
muscle structure development	GO:0061061	196	0.010
cellular macromolecule localization	GO:0070727	21	0.010	Mouse Worm
peripheral nervous system development	GO:0007422	55	0.010
positive regulation of macromolecule metabolic process	GO:0010604	93	0.010	Human
positive regulation of nucleobase containing compound metabolic process	GO:0045935	69	0.010	Mouse
aromatic compound biosynthetic process	GO:0019438	217	0.010	Human Mouse Worm

sumo1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

	Disease	DO term ID	Size	Probability	Func Analog Org
	disease of cellular proliferation	DOID:14566	0	0.011

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