IMP: Integrative Multi-species Prediction

Danio rerio

40 known processes

atoh1b

atonal homolog 1b

(Aliases: Atoh1.2)

ZFIN: ZDB-GENE-041201-1
Entrez: 493915
Ensembl: ENSDARG00000033400
UniProtKB: B3DH94

Process Predictions
Disease Predictions

atoh1b biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
hair cell differentiation	GO:0035315	32	0.992
ear development	GO:0043583	127	0.976
axon guidance	GO:0007411	86	0.955	Mouse
hindbrain development	GO:0030902	91	0.939	Zebrafish
epidermal cell differentiation	GO:0009913	36	0.933
posterior lateral line development	GO:0048916	38	0.927	Zebrafish
epidermis development	GO:0008544	48	0.921
hematopoietic stem cell differentiation	GO:0060218	20	0.919	Zebrafish
ear morphogenesis	GO:0042471	64	0.918	Mouse
chemotaxis	GO:0006935	104	0.918	Mouse
inner ear morphogenesis	GO:0042472	63	0.914	Mouse
olfactory lobe development	GO:0021988	4	0.898	Zebrafish
mechanoreceptor differentiation	GO:0042490	37	0.869
mesoderm formation	GO:0001707	43	0.850	Zebrafish
posterior lateral line neuromast development	GO:0048919	20	0.848	Zebrafish
central nervous system development	GO:0007417	387	0.845	Zebrafish Mouse Fly
cell fate specification	GO:0001708	68	0.840	Mouse
cellular component movement	GO:0006928	335	0.838	Mouse
neuron development	GO:0048666	262	0.822	Zebrafish Mouse Worm Fly
embryonic organ development	GO:0048568	381	0.800	Zebrafish Mouse
retina layer formation	GO:0010842	24	0.799	Zebrafish
endocrine system development	GO:0035270	65	0.789	Zebrafish
axonogenesis	GO:0007409	152	0.789	Mouse
morphogenesis of embryonic epithelium	GO:0016331	30	0.787	Zebrafish
sensory organ morphogenesis	GO:0090596	200	0.784	Zebrafish Mouse Fly
embryonic organ morphogenesis	GO:0048562	274	0.780	Zebrafish Mouse
tube morphogenesis	GO:0035239	349	0.778	Zebrafish
cell projection organization	GO:0030030	284	0.777	Zebrafish Mouse Fly
nucleic acid templated transcription	GO:0097659	181	0.777	Zebrafish Mouse Fly
mesodermal cell differentiation	GO:0048333	21	0.776	Zebrafish
heterocycle biosynthetic process	GO:0018130	215	0.773	Zebrafish Mouse Fly
mesoderm development	GO:0007498	88	0.767	Zebrafish
nucleobase containing compound biosynthetic process	GO:0034654	205	0.745	Zebrafish Mouse Fly
olfactory placode development	GO:0071698	12	0.739	Zebrafish
auditory receptor cell differentiation	GO:0042491	15	0.737
sensory system development	GO:0048880	76	0.726	Zebrafish
biosynthetic process	GO:0009058	294	0.711	Zebrafish Mouse Fly
regulation of multicellular organismal process	GO:0051239	277	0.692	Zebrafish Mouse
posterior lateral line system development	GO:0048915	46	0.690	Zebrafish
neuron differentiation	GO:0030182	353	0.679
positive regulation of epithelial cell differentiation	GO:0030858	2	0.665	Zebrafish Mouse
taxis	GO:0042330	109	0.638	Mouse
morphogenesis of an epithelium	GO:0002009	333	0.636	Zebrafish
digestive system development	GO:0055123	289	0.634	Zebrafish
nerve development	GO:0021675	45	0.634	Zebrafish
mechanosensory lateral line system development	GO:0048881	49	0.611	Zebrafish
organic substance biosynthetic process	GO:1901576	289	0.603	Zebrafish Mouse Fly
epithelial cell differentiation	GO:0030855	116	0.597
smoothened signaling pathway	GO:0007224	30	0.591	Fly
olfactory bulb development	GO:0021772	4	0.584	Zebrafish
regulation of transcription from rna polymerase ii promoter	GO:0006357	114	0.579	Mouse Fly
heart morphogenesis	GO:0003007	156	0.578	Zebrafish
regulation of cell differentiation	GO:0045595	142	0.574	Zebrafish Mouse
blood vessel morphogenesis	GO:0048514	216	0.571	Zebrafish
response to external stimulus	GO:0009605	264	0.568	Mouse
positive regulation of nitrogen compound metabolic process	GO:0051173	69	0.565	Zebrafish Mouse Fly
cell morphogenesis involved in differentiation	GO:0000904	195	0.565	Mouse Fly
cranial nerve development	GO:0021545	42	0.564	Zebrafish
epithelial tube formation	GO:0072175	19	0.562	Zebrafish
regulation of rna metabolic process	GO:0051252	224	0.556	Zebrafish Mouse Fly
tube formation	GO:0035148	25	0.523	Zebrafish
generation of neurons	GO:0048699	385	0.523
auditory receptor cell fate commitment	GO:0009912	4	0.520
head development	GO:0060322	303	0.519	Zebrafish Mouse Fly
cellular component morphogenesis	GO:0032989	336	0.516	Mouse Fly
neuron projection guidance	GO:0097485	86	0.515	Mouse
determination of left right symmetry	GO:0007368	179	0.513	Zebrafish
skin development	GO:0043588	54	0.511
digestive tract morphogenesis	GO:0048546	231	0.504	Zebrafish
neuron fate determination	GO:0048664	2	0.504
inner ear receptor cell differentiation	GO:0060113	29	0.494
rna biosynthetic process	GO:0032774	181	0.493	Zebrafish Mouse Fly
regulation of transcription dna templated	GO:0006355	213	0.492	Zebrafish Mouse Fly
chordate embryonic development	GO:0043009	271	0.489	Zebrafish
brain development	GO:0007420	293	0.484	Zebrafish Mouse Fly
retina morphogenesis in camera type eye	GO:0060042	79	0.481	Zebrafish
inner ear development	GO:0048839	126	0.479
eye development	GO:0001654	277	0.475	Zebrafish Fly
regulation of mechanoreceptor differentiation	GO:0045631	1	0.464	Mouse
regulation of multicellular organismal development	GO:2000026	223	0.459	Zebrafish Mouse
neuromast development	GO:0048884	46	0.459	Zebrafish
forebrain neuron development	GO:0021884	7	0.457	Zebrafish
response to stress	GO:0006950	263	0.455	Zebrafish
pectoral fin development	GO:0033339	50	0.438	Zebrafish
skeletal system development	GO:0001501	181	0.435	Zebrafish
cell part morphogenesis	GO:0032990	246	0.416	Mouse Fly
pancreas development	GO:0031016	84	0.415	Zebrafish
epithelial tube morphogenesis	GO:0060562	148	0.410	Zebrafish
positive regulation of transcription dna templated	GO:0045893	57	0.410	Zebrafish Mouse Fly
gastrulation	GO:0007369	208	0.410	Zebrafish
rna metabolic process	GO:0016070	219	0.407	Zebrafish Mouse Fly
posterior lateral line nerve development	GO:0048918	8	0.405	Zebrafish
inner ear receptor cell fate commitment	GO:0060120	4	0.403
heart contraction	GO:0060047	71	0.402	Zebrafish
cell projection morphogenesis	GO:0048858	244	0.395	Mouse Fly
sensory organ development	GO:0007423	393	0.395
embryonic epithelial tube formation	GO:0001838	17	0.394	Zebrafish
hematopoietic progenitor cell differentiation	GO:0002244	23	0.389	Zebrafish
lateral line system development	GO:0048925	76	0.388	Zebrafish
response to wounding	GO:0009611	116	0.383	Zebrafish
regulation of neurogenesis	GO:0050767	87	0.379	Zebrafish Mouse
neuromuscular process controlling balance	GO:0050885	3	0.376
pectoral fin morphogenesis	GO:0035138	29	0.375	Zebrafish
mesoderm morphogenesis	GO:0048332	51	0.373	Zebrafish
regulation of nucleic acid templated transcription	GO:1903506	213	0.371	Zebrafish Mouse Fly
central nervous system neuron development	GO:0021954	29	0.367	Zebrafish
positive regulation of metabolic process	GO:0009893	108	0.364	Zebrafish Mouse Fly
cardiocyte differentiation	GO:0035051	44	0.359	Zebrafish
cell fate commitment	GO:0045165	99	0.358
gland development	GO:0048732	143	0.355	Zebrafish
proepicardium development	GO:0003342	4	0.353	Zebrafish
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	22	0.346	Mouse Fly
regulation of cellular biosynthetic process	GO:0031326	245	0.338	Zebrafish Mouse Fly
regulation of gene expression	GO:0010468	265	0.337	Zebrafish Mouse Fly
aromatic compound biosynthetic process	GO:0019438	217	0.335	Zebrafish Mouse Fly
circulatory system process	GO:0003013	87	0.334	Zebrafish
neuron fate specification	GO:0048665	20	0.333	Mouse
ectodermal placode development	GO:0071696	37	0.329	Zebrafish
embryonic viscerocranium morphogenesis	GO:0048703	52	0.326	Zebrafish
neuron projection morphogenesis	GO:0048812	161	0.325	Mouse Fly
neuron projection development	GO:0031175	180	0.323	Zebrafish Mouse Fly
embryonic skeletal system development	GO:0048706	97	0.320	Zebrafish
regulation of cellular macromolecule biosynthetic process	GO:2000112	222	0.318	Zebrafish Mouse Fly
hematopoietic or lymphoid organ development	GO:0048534	191	0.317	Zebrafish
formation of primary germ layer	GO:0001704	62	0.317	Zebrafish
organic cyclic compound biosynthetic process	GO:1901362	223	0.311	Zebrafish Mouse Fly
regulation of developmental process	GO:0050793	247	0.309	Zebrafish Mouse
definitive hemopoiesis	GO:0060216	18	0.308	Zebrafish
endocrine pancreas development	GO:0031018	27	0.306	Zebrafish
regulation of inner ear receptor cell differentiation	GO:2000980	1	0.296	Mouse
primitive hemopoiesis	GO:0060215	27	0.295	Zebrafish
posterior lateral line neuromast hair cell differentiation	GO:0048923	8	0.294	Zebrafish
appendage morphogenesis	GO:0035107	56	0.294	Zebrafish Fly
immune system process	GO:0002376	241	0.292	Zebrafish
axon regeneration	GO:0031103	14	0.290	Zebrafish
embryonic heart tube development	GO:0035050	133	0.290	Zebrafish
lateral mesoderm development	GO:0048368	23	0.285	Zebrafish
transcription dna templated	GO:0006351	181	0.282	Zebrafish Mouse Fly
positive regulation of cellular metabolic process	GO:0031325	94	0.280	Zebrafish Mouse Fly
nitrogen compound metabolic process	GO:0006807	319	0.276	Zebrafish Mouse Fly
gene expression	GO:0010467	252	0.275	Zebrafish Mouse Fly
cell morphogenesis	GO:0000902	289	0.275	Mouse Fly
organ formation	GO:0048645	17	0.274	Fly
pharyngeal system development	GO:0060037	18	0.273	Zebrafish
stem cell differentiation	GO:0048863	117	0.269	Zebrafish
swimming behavior	GO:0036269	8	0.269	Zebrafish
response to axon injury	GO:0048678	14	0.266	Zebrafish
localization of cell	GO:0051674	244	0.263	Mouse
regulation of nervous system development	GO:0051960	90	0.257	Zebrafish Mouse
camera type eye morphogenesis	GO:0048593	108	0.254	Zebrafish
regionalization	GO:0003002	274	0.250	Fly
regeneration	GO:0031099	91	0.246	Zebrafish
macromolecule biosynthetic process	GO:0009059	227	0.242	Zebrafish Mouse Fly
programmed cell death	GO:0012501	119	0.242	Mouse
cardioblast differentiation	GO:0010002	9	0.239	Zebrafish
erythrocyte differentiation	GO:0030218	54	0.238	Zebrafish
septum transversum development	GO:0003343	4	0.238	Zebrafish
myeloid cell differentiation	GO:0030099	86	0.230	Zebrafish
cellular macromolecule metabolic process	GO:0044260	391	0.229	Zebrafish Mouse Fly
peripheral nervous system development	GO:0007422	55	0.224	Zebrafish
artery morphogenesis	GO:0048844	14	0.221	Zebrafish
embryonic heart tube morphogenesis	GO:0003143	108	0.219	Zebrafish
nitrogen compound transport	GO:0071705	23	0.218
response to drug	GO:0042493	3	0.216
cellular nitrogen compound biosynthetic process	GO:0044271	218	0.214	Zebrafish Mouse Fly
anterior lateral line nerve development	GO:0048909	4	0.213	Zebrafish
cell migration	GO:0016477	237	0.206	Mouse
regulation of biosynthetic process	GO:0009889	250	0.201	Zebrafish Mouse Fly
central nervous system neuron differentiation	GO:0021953	74	0.201	Zebrafish
positive regulation of rna metabolic process	GO:0051254	59	0.200	Zebrafish Mouse Fly
skeletal system morphogenesis	GO:0048705	102	0.199	Zebrafish
forebrain generation of neurons	GO:0021872	14	0.198	Zebrafish
positive regulation of gene expression	GO:0010628	71	0.193	Zebrafish Mouse Fly
system process	GO:0003008	185	0.192	Zebrafish Fly
positive regulation of biosynthetic process	GO:0009891	68	0.191	Zebrafish Mouse Fly
nucleic acid metabolic process	GO:0090304	244	0.186	Zebrafish Mouse Fly
positive regulation of macromolecule biosynthetic process	GO:0010557	59	0.186	Zebrafish Mouse Fly
positive regulation of cellular biosynthetic process	GO:0031328	68	0.183	Zebrafish Mouse Fly
positive regulation of nucleic acid templated transcription	GO:1903508	57	0.181	Zebrafish Mouse Fly
nucleobase containing compound metabolic process	GO:0006139	274	0.180	Zebrafish Mouse Fly
embryonic heart tube formation	GO:0003144	1	0.175	Zebrafish
cell morphogenesis involved in neuron differentiation	GO:0048667	163	0.175	Mouse Fly
fin morphogenesis	GO:0033334	53	0.174	Zebrafish
lateral line development	GO:0048882	66	0.172	Zebrafish
neural retina development	GO:0003407	49	0.172	Zebrafish
neural plate development	GO:0001840	10	0.170	Zebrafish
regulation of metabolic process	GO:0019222	359	0.170	Zebrafish Mouse Fly
cellular aromatic compound metabolic process	GO:0006725	295	0.165	Zebrafish Mouse Fly
negative regulation of cellular process	GO:0048523	283	0.161	Zebrafish Mouse
auditory receptor cell fate determination	GO:0042668	2	0.155
positive regulation of biological process	GO:0048518	253	0.154	Zebrafish Mouse Fly
transcription from rna polymerase ii promoter	GO:0006366	80	0.154	Mouse Fly
neuron recognition	GO:0008038	18	0.153	Zebrafish Fly
otolith development	GO:0048840	32	0.148
sensory perception of sound	GO:0007605	9	0.147	Fly
cell surface receptor signaling pathway	GO:0007166	325	0.145	Fly
regulation of macromolecule biosynthetic process	GO:0010556	225	0.144	Zebrafish Mouse Fly
apoptotic process	GO:0006915	116	0.143	Mouse
locomotion	GO:0040011	313	0.142	Mouse
neuron fate commitment	GO:0048663	26	0.141
behavior	GO:0007610	74	0.141	Zebrafish Fly
embryo development ending in birth or egg hatching	GO:0009792	271	0.140	Zebrafish Worm
carboxylic acid metabolic process	GO:0019752	22	0.138
cell fate determination	GO:0001709	7	0.137
heterocycle metabolic process	GO:0046483	290	0.136	Zebrafish Mouse Fly
somite development	GO:0061053	96	0.135
endothelial cell differentiation	GO:0045446	20	0.133	Zebrafish
compound eye development	GO:0048749	2	0.132	Fly
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	42	0.130	Fly
response to chemical	GO:0042221	320	0.130	Mouse
regulation of nitrogen compound metabolic process	GO:0051171	251	0.129	Zebrafish Mouse Fly
fin development	GO:0033333	77	0.126	Zebrafish
positive regulation of endothelial cell differentiation	GO:0045603	2	0.125	Zebrafish
vasculogenesis	GO:0001570	41	0.123	Zebrafish
forebrain neuron differentiation	GO:0021879	14	0.119	Zebrafish
regulation of macromolecule metabolic process	GO:0060255	317	0.118	Zebrafish Mouse Fly
erythrocyte homeostasis	GO:0034101	55	0.115	Zebrafish
response to nutrient	GO:0007584	3	0.115
axonal fasciculation	GO:0007413	11	0.112	Zebrafish
endocardium morphogenesis	GO:0003160	4	0.112	Zebrafish
axon development	GO:0061564	166	0.112	Zebrafish Mouse
positive regulation of cellular process	GO:0048522	201	0.111	Zebrafish Mouse Fly
response to bacterium	GO:0009617	58	0.109
heart process	GO:0003015	71	0.108	Zebrafish
positive regulation of cellular amino acid metabolic process	GO:0045764	0	0.108
regulation of cell death	GO:0010941	103	0.107	Mouse
endothelium development	GO:0003158	25	0.106	Zebrafish
monoamine transport	GO:0015844	1	0.105
appendage development	GO:0048736	80	0.104	Zebrafish Fly
segmentation	GO:0035282	97	0.103
regulation of endothelial cell differentiation	GO:0045601	3	0.102	Zebrafish
determination of intestine left right asymmetry	GO:0071908	2	0.102	Zebrafish
cardiogenic plate morphogenesis	GO:0003142	1	0.100	Zebrafish
retina development in camera type eye	GO:0060041	146	0.098	Zebrafish
vasculature development	GO:0001944	278	0.096	Zebrafish
embryonic skeletal system morphogenesis	GO:0048704	93	0.095	Zebrafish
myeloid cell homeostasis	GO:0002262	56	0.094	Zebrafish
somitogenesis	GO:0001756	87	0.091
regulation of cellular amino acid metabolic process	GO:0006521	0	0.091
cellular biosynthetic process	GO:0044249	286	0.089	Zebrafish Mouse Fly
determination of digestive tract left right asymmetry	GO:0071907	10	0.089	Zebrafish
erythrocyte development	GO:0048821	24	0.088	Zebrafish
cellular amine metabolic process	GO:0044106	2	0.086
larval development	GO:0002164	2	0.086
positive regulation of erk1 and erk2 cascade	GO:0070374	2	0.085
camera type eye development	GO:0043010	222	0.084	Zebrafish
amino acid transport	GO:0006865	2	0.082
cell death	GO:0008219	121	0.082	Mouse
defense response	GO:0006952	47	0.080
exocrine pancreas development	GO:0031017	28	0.079	Zebrafish
neuron migration	GO:0001764	22	0.079	Mouse
artery development	GO:0060840	22	0.079	Zebrafish
somatic muscle development	GO:0007525	4	0.078
negative regulation of cell development	GO:0010721	26	0.077	Zebrafish
regulation of endodermal cell fate specification	GO:0042663	15	0.077
cellular amino acid metabolic process	GO:0006520	7	0.076
signal transduction	GO:0007165	455	0.076	Fly
tissue regeneration	GO:0042246	74	0.075
detection of chemical stimulus involved in sensory perception	GO:0050907	3	0.075
neurological system process	GO:0050877	62	0.075	Fly
cellular response to chemical stimulus	GO:0070887	157	0.074
digestive tract development	GO:0048565	265	0.074	Zebrafish
transport	GO:0006810	220	0.074
neuromast hair cell development	GO:0035675	6	0.073	Zebrafish
response to alkaloid	GO:0043279	2	0.073
response to organic substance	GO:0010033	153	0.072
regulation of cell cycle	GO:0051726	52	0.072	Zebrafish
embryonic cranial skeleton morphogenesis	GO:0048701	90	0.071	Zebrafish
regulation of epidermis development	GO:0045682	2	0.071	Mouse
regulation of neuron differentiation	GO:0045664	56	0.071	Mouse
single organism biosynthetic process	GO:0044711	71	0.070
regulation of nucleobase containing compound metabolic process	GO:0019219	250	0.070	Zebrafish Mouse Fly
dicarboxylic acid transport	GO:0006835	1	0.069
sensory perception of mechanical stimulus	GO:0050954	16	0.069	Fly
organic cyclic compound metabolic process	GO:1901360	301	0.068	Zebrafish Mouse Fly
ion transport	GO:0006811	114	0.068
cellular protein modification process	GO:0006464	100	0.068
growth	GO:0040007	174	0.066
cellular macromolecule biosynthetic process	GO:0034645	224	0.066	Zebrafish Mouse Fly
maintenance of location	GO:0051235	4	0.065
blood vessel development	GO:0001568	246	0.064	Zebrafish
regulation of cellular amine metabolic process	GO:0033238	0	0.064
response to endogenous stimulus	GO:0009719	83	0.064
negative regulation of neurogenesis	GO:0050768	20	0.064	Zebrafish
endocardium development	GO:0003157	9	0.062	Zebrafish
homeostatic process	GO:0042592	142	0.062	Zebrafish
death	GO:0016265	121	0.060	Mouse
positive regulation of cellular amine metabolic process	GO:0033240	0	0.060
positive regulation of nervous system development	GO:0051962	25	0.059	Zebrafish Mouse
nephron morphogenesis	GO:0072028	2	0.059
response to external biotic stimulus	GO:0043207	97	0.059
regulation of rna biosynthetic process	GO:2001141	213	0.059	Zebrafish Mouse Fly
positive regulation of cell differentiation	GO:0045597	30	0.058	Zebrafish Mouse
peripheral nervous system neuron development	GO:0048935	22	0.058	Zebrafish
hemopoiesis	GO:0030097	183	0.058	Zebrafish
immune system development	GO:0002520	191	0.057	Zebrafish
negative regulation of cellular biosynthetic process	GO:0031327	55	0.057
specification of symmetry	GO:0009799	204	0.056	Zebrafish
negative regulation of multicellular organismal process	GO:0051241	69	0.056	Zebrafish
blood circulation	GO:0008015	87	0.055	Zebrafish
positive regulation of neuron differentiation	GO:0045666	12	0.055	Mouse
negative regulation of biological process	GO:0048519	304	0.053	Zebrafish Mouse
regulation of cellular ketone metabolic process	GO:0010565	7	0.053
startle response	GO:0001964	4	0.050
sensory perception	GO:0007600	39	0.050	Fly
regulation of signal transduction	GO:0009966	225	0.050
cell recognition	GO:0008037	19	0.049	Zebrafish Fly
regulation of response to stimulus	GO:0048583	269	0.049
macromolecule modification	GO:0043412	111	0.048
cellular ketone metabolic process	GO:0042180	11	0.048
cellular nitrogen compound metabolic process	GO:0034641	290	0.048	Zebrafish Mouse Fly
stem cell maintenance	GO:0019827	4	0.046
establishment of localization	GO:0051234	244	0.046
positive regulation of macromolecule metabolic process	GO:0010604	93	0.046	Zebrafish Mouse Fly
urogenital system development	GO:0001655	97	0.046
telencephalon development	GO:0021537	14	0.045	Zebrafish Mouse
response to other organism	GO:0051707	97	0.044
nephron tubule morphogenesis	GO:0072078	1	0.044
phagocytosis	GO:0006909	3	0.043
mesenchyme development	GO:0060485	127	0.042	Zebrafish
glial cell migration	GO:0008347	3	0.042
regulation of apoptotic process	GO:0042981	98	0.042	Mouse
pigmentation	GO:0043473	85	0.042
organic substance transport	GO:0071702	58	0.042
notochord development	GO:0030903	54	0.041
multi organism process	GO:0051704	134	0.040	Fly
wound healing	GO:0042060	90	0.040
defense response to other organism	GO:0098542	33	0.040
single organism localization	GO:1902578	225	0.040
regulation of cell communication	GO:0010646	232	0.040
nephron epithelium morphogenesis	GO:0072088	1	0.039
adult behavior	GO:0030534	2	0.039
developmental growth involved in morphogenesis	GO:0060560	86	0.039
response to biotic stimulus	GO:0009607	97	0.038
synaptic transmission	GO:0007268	35	0.038
phagocytosis engulfment	GO:0006911	1	0.038
positive regulation of nucleobase containing compound metabolic process	GO:0045935	69	0.038	Zebrafish Mouse Fly
myeloid cell development	GO:0061515	32	0.037	Zebrafish
cell fate commitment involved in pattern specification	GO:0060581	6	0.037	Fly
carbohydrate derivative biosynthetic process	GO:1901137	43	0.037
muscle organ development	GO:0007517	101	0.037
single organism transport	GO:0044765	206	0.036
anterior lateral line system development	GO:0048898	9	0.036	Zebrafish
response to hexose	GO:0009746	3	0.036
hemangioblast cell differentiation	GO:0060217	5	0.036	Zebrafish
regulation of synapse assembly	GO:0051963	3	0.036
intracellular signal transduction	GO:0035556	85	0.036
cell cell signaling	GO:0007267	52	0.036
kidney development	GO:0001822	92	0.036
heart development	GO:0007507	313	0.035	Zebrafish
oxoacid metabolic process	GO:0043436	31	0.035
erk1 and erk2 cascade	GO:0070371	4	0.035
lipid metabolic process	GO:0006629	52	0.034
negative regulation of programmed cell death	GO:0043069	58	0.034	Mouse
protein modification process	GO:0036211	100	0.034
regulation of epithelial cell differentiation	GO:0030856	7	0.033	Zebrafish Mouse
small molecule metabolic process	GO:0044281	77	0.033
reflex	GO:0060004	2	0.033
angiogenesis	GO:0001525	158	0.033	Zebrafish
apoptotic process involved in development	GO:1902742	2	0.033
organic acid metabolic process	GO:0006082	31	0.033
thyroid gland development	GO:0030878	12	0.032	Zebrafish
stem cell fate commitment	GO:0048865	1	0.032
negative regulation of developmental process	GO:0051093	65	0.032	Zebrafish
stem cell fate determination	GO:0048867	1	0.032
hormone transport	GO:0009914	2	0.032
determination of heart left right asymmetry	GO:0061371	117	0.032
vestibular reflex	GO:0060005	2	0.031
glucose homeostasis	GO:0042593	1	0.031
inorganic anion transport	GO:0015698	25	0.031
cellular response to decreased oxygen levels	GO:0036294	1	0.031
positive regulation of cell communication	GO:0010647	56	0.030
positive regulation of neurogenesis	GO:0050769	24	0.030	Zebrafish Mouse
regulation of cell fate commitment	GO:0010453	22	0.029
amine metabolic process	GO:0009308	2	0.029
phosphate containing compound metabolic process	GO:0006796	108	0.029
cellular component disassembly	GO:0022411	1	0.029
determination of bilateral symmetry	GO:0009855	204	0.028	Zebrafish
regulation of erk1 and erk2 cascade	GO:0070372	4	0.028
anion transport	GO:0006820	38	0.028
response to organic cyclic compound	GO:0014070	51	0.028
cellular response to oxygen levels	GO:0071453	1	0.028
regulation of cell fate specification	GO:0042659	20	0.028
regulation of embryonic development	GO:0045995	47	0.027
regulation of organ growth	GO:0046620	3	0.027
developmental growth	GO:0048589	166	0.027
positive regulation of striated muscle tissue development	GO:0045844	1	0.026
axon extension	GO:0048675	45	0.026
regulation of cell development	GO:0060284	100	0.026	Zebrafish Mouse
specification of organ identity	GO:0010092	2	0.026
renal system development	GO:0072001	94	0.026
negative regulation of biosynthetic process	GO:0009890	55	0.025
mechanosensory behavior	GO:0007638	2	0.025
post embryonic organ development	GO:0048569	4	0.025	Fly
positive regulation of rna biosynthetic process	GO:1902680	57	0.024	Zebrafish Mouse Fly
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	GO:0002460	4	0.024
positive regulation of cell development	GO:0010720	25	0.024	Zebrafish Mouse
cellular response to extracellular stimulus	GO:0031668	2	0.024
striated muscle tissue development	GO:0014706	110	0.024
regulation of peptidyl tyrosine phosphorylation	GO:0050730	1	0.024
skin morphogenesis	GO:0043589	7	0.024
regulation of reproductive process	GO:2000241	4	0.024
regulation of programmed cell death	GO:0043067	101	0.024	Mouse
carbohydrate homeostasis	GO:0033500	1	0.024
neuromast hair cell differentiation	GO:0048886	12	0.024	Zebrafish
positive regulation of secretion by cell	GO:1903532	1	0.023
response to amino acid	GO:0043200	2	0.023
neuromuscular process	GO:0050905	7	0.023
female gonad development	GO:0008585	4	0.023
g1 s transition of mitotic cell cycle	GO:0000082	1	0.023
positive regulation of lipid metabolic process	GO:0045834	1	0.023
fin regeneration	GO:0031101	51	0.023
developmental programmed cell death	GO:0010623	4	0.022
regulation of endodermal cell differentiation	GO:1903224	15	0.022
muscle fiber development	GO:0048747	52	0.022
regulation of cell morphogenesis	GO:0022604	42	0.022
negative regulation of metabolic process	GO:0009892	86	0.022
neuron apoptotic process	GO:0051402	20	0.022
l amino acid transport	GO:0015807	1	0.022
synapse organization	GO:0050808	21	0.022
negative regulation of macromolecule biosynthetic process	GO:0010558	48	0.021
regulation of primary metabolic process	GO:0080090	311	0.021	Zebrafish Mouse Fly
organic acid catabolic process	GO:0016054	3	0.021
neuron projection extension	GO:1990138	45	0.021
hindbrain morphogenesis	GO:0021575	22	0.021	Zebrafish
cellular amino acid biosynthetic process	GO:0008652	2	0.021
protein metabolic process	GO:0019538	183	0.021
response to mechanical stimulus	GO:0009612	24	0.021
negative regulation of nucleobase containing compound metabolic process	GO:0045934	59	0.021
extrinsic apoptotic signaling pathway	GO:0097191	3	0.021
tissue remodeling	GO:0048771	4	0.021
germ line stem cell maintenance	GO:0030718	2	0.021
regulation of axonogenesis	GO:0050770	32	0.021
cell motility	GO:0048870	244	0.020	Mouse
striated muscle cell development	GO:0055002	108	0.020
negative regulation of cell fate specification	GO:0009996	11	0.020
development of primary female sexual characteristics	GO:0046545	4	0.020
ion transmembrane transport	GO:0034220	91	0.020
cell fate commitment involved in formation of primary germ layer	GO:0060795	26	0.020
negative regulation of response to stimulus	GO:0048585	104	0.019
positive regulation of secretion	GO:0051047	1	0.019
insulin like growth factor receptor signaling pathway	GO:0048009	4	0.019
regulation of canonical wnt signaling pathway	GO:0060828	34	0.019
response to decreased oxygen levels	GO:0036293	25	0.019
carboxylic acid transport	GO:0046942	8	0.019
cellular component biogenesis	GO:0044085	178	0.019
carbohydrate derivative metabolic process	GO:1901135	61	0.019
regulation of blood pressure	GO:0008217	1	0.019
regulation of anatomical structure morphogenesis	GO:0022603	130	0.019
regulation of epithelial cell proliferation	GO:0050678	3	0.019
activation of mapk activity	GO:0000187	3	0.019
defense response to bacterium	GO:0042742	22	0.019
neuroblast fate determination	GO:0007400	1	0.019
cellular response to endogenous stimulus	GO:0071495	68	0.019
negative regulation of secretion by cell	GO:1903531	2	0.018
negative regulation of hormone secretion	GO:0046888	2	0.018
exocrine system development	GO:0035272	28	0.018	Zebrafish
positive regulation of peptidyl tyrosine phosphorylation	GO:0050731	1	0.018
positive regulation of transport	GO:0051050	2	0.018
response to corticosteroid	GO:0031960	1	0.018
primary neural tube formation	GO:0014020	1	0.018
macromolecule localization	GO:0033036	54	0.018
organic hydroxy compound transport	GO:0015850	14	0.018
membrane invagination	GO:0010324	1	0.018
negative regulation of secretion	GO:0051048	2	0.018
negative regulation of nitrogen compound metabolic process	GO:0051172	59	0.017
response to abiotic stimulus	GO:0009628	122	0.017
actin filament based movement	GO:0030048	1	0.017
cellular response to external stimulus	GO:0071496	2	0.017
response to glucocorticoid	GO:0051384	1	0.017
response to monosaccharide	GO:0034284	3	0.017
detection of stimulus involved in sensory perception	GO:0050906	21	0.017
detection of temperature stimulus	GO:0016048	0	0.017
regulation of protein ubiquitination	GO:0031396	3	0.016
organ regeneration	GO:0031100	1	0.016
inositol lipid mediated signaling	GO:0048017	2	0.016
positive regulation of muscle organ development	GO:0048636	1	0.016
regulation of cytokine production	GO:0001817	3	0.016
regulation of protein complex assembly	GO:0043254	3	0.016
aging	GO:0007568	2	0.016
dicarboxylic acid metabolic process	GO:0043648	1	0.016
lipid homeostasis	GO:0055088	3	0.016
negative regulation of reproductive process	GO:2000242	3	0.016
equilibrioception	GO:0050957	2	0.016
phosphatidylinositol mediated signaling	GO:0048015	2	0.016
ceramide biosynthetic process	GO:0046513	1	0.016
cellular response to nutrient levels	GO:0031669	2	0.016
negative regulation of cell fate commitment	GO:0010454	13	0.016
neuron death	GO:0070997	21	0.015
positive regulation of cellular component biogenesis	GO:0044089	3	0.015
synaptic growth at neuromuscular junction	GO:0051124	2	0.015
cerebellum development	GO:0021549	17	0.015
midbrain development	GO:0030901	28	0.015
regulation of response to stress	GO:0080134	36	0.015

atoh1b disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.220
disease of cellular proliferation	DOID:14566	0.023
cancer	DOID:162	0.023
nervous system disease	DOID:863	0.019
sensory system disease	DOID:0050155	0.019

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