Danio rerio

0 known processes

hmbsb

hydroxymethylbilane synthase, b

(Aliases: im:7140060,PBGD,id:ibd5004,hmbsl,zgc:110690)

hmbsb biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
erythrocyte maturationGO:004324980.555
myeloid cell differentiationGO:0030099860.416
hemopoiesisGO:00300971830.394
hematopoietic or lymphoid organ developmentGO:00485341910.391
transcription dna templatedGO:00063511810.292
erythrocyte differentiationGO:0030218540.292
aromatic compound biosynthetic processGO:00194382170.244
immune system developmentGO:00025201910.244
cellular macromolecule metabolic processGO:00442603910.231
nucleic acid metabolic processGO:00903042440.229
regulation of transcription dna templatedGO:00063552130.216
regulation of primary metabolic processGO:00800903110.191
regulation of cellular metabolic processGO:00313233200.188
regulation of macromolecule metabolic processGO:00602553170.186
cellular aromatic compound metabolic processGO:00067252950.180
heme metabolic processGO:004216890.176
cofactor biosynthetic processGO:0051188100.175
erythrocyte homeostasisGO:0034101550.157
larval developmentGO:000216420.151
positive regulation of i kappab kinase nf kappab signalingGO:004312330.145
cellular macromolecule biosynthetic processGO:00346452240.141
agingGO:000756820.134
biosynthetic processGO:00090582940.132
tetrapyrrole biosynthetic processGO:003301480.123
embryonic organ developmentGO:00485683810.121
cellular component movementGO:00069283350.120
organic substance biosynthetic processGO:19015762890.114
digestive tract morphogenesisGO:00485462310.110
cellular nitrogen compound metabolic processGO:00346412900.103
gene expressionGO:00104672520.102
regulation of gene expressionGO:00104682650.101
organic cyclic compound biosynthetic processGO:19013622230.101
cellular response to external stimulusGO:007149620.100
negative regulation of cell differentiationGO:0045596460.100
cellular response to reactive oxygen speciesGO:003461420.099
response to oxygen radicalGO:000030520.084
nitrogen compound metabolic processGO:00068073190.081
iron ion homeostasisGO:005507240.080
cellular component biogenesisGO:00440851780.079
response to stressGO:00069502630.078
cell surface receptor signaling pathwayGO:00071663250.076
regulation of protein targetingGO:190353320.076
cellular amide metabolic processGO:004360340.075
macromolecule biosynthetic processGO:00090592270.075
regulation of biosynthetic processGO:00098892500.073
multicellular organism growthGO:003526440.072
regulation of biological qualityGO:00650082630.071
heterocycle metabolic processGO:00464832900.070
protein metabolic processGO:00195381830.070
regulation of reproductive processGO:200024140.068
liver developmentGO:0001889960.068
maintenance of locationGO:005123540.067
regulation of metabolic processGO:00192223590.066
heart developmentGO:00075073130.066
rna metabolic processGO:00160702190.064
i kappab kinase nf kappab signalingGO:000724940.063
homeostatic processGO:00425921420.062
transcription from rna polymerase ii promoterGO:0006366800.059
hemoglobin biosynthetic processGO:004254180.058
primitive erythrocyte differentiationGO:006031950.057
heart loopingGO:0001947940.057
cellular biosynthetic processGO:00442492860.056
rna biosynthetic processGO:00327741810.056
osteoclast differentiationGO:003031610.054
regulation of response to stimulusGO:00485832690.054
cellular response to extracellular stimulusGO:003166820.053
cellular response to starvationGO:000926710.053
embryonic hemopoiesisGO:0035162530.053
lateral inhibitionGO:004633110.052
nucleic acid templated transcriptionGO:00976591810.052
immune system processGO:00023762410.052
ventricular cardiac muscle tissue morphogenesisGO:005501020.051
regulation of extrinsic apoptotic signaling pathwayGO:200123630.049
response to hydrogen peroxideGO:004254230.049
digestive system developmentGO:00551232890.048
single organism localizationGO:19025782250.045
negative regulation of cellular processGO:00485232830.045
muscle structure developmentGO:00610611960.044
deathGO:00162651210.044
porphyrin containing compound biosynthetic processGO:000677980.044
transportGO:00068102200.044
cellular protein metabolic processGO:00442671290.044
nucleobase containing compound biosynthetic processGO:00346542050.043
regulation of bone mineralizationGO:003050020.043
regulation of protein complex assemblyGO:004325430.043
hemoglobin metabolic processGO:0020027120.043
protein localization to nucleusGO:003450430.043
signal transductionGO:00071654550.043
regulation of i kappab kinase nf kappab signalingGO:004312240.042
regulation of establishment of protein localizationGO:007020140.042
regulation of nucleic acid templated transcriptionGO:19035062130.042
neuron developmentGO:00486662620.042
positive regulation of metabolic processGO:00098931080.042
tube morphogenesisGO:00352393490.041
regulation of signalingGO:00230512350.041
head developmentGO:00603223030.040
establishment of localizationGO:00512342440.040
regulation of cell activationGO:005086510.040
inorganic anion transportGO:0015698250.039
response to bacteriumGO:0009617580.038
positive regulation of protein complex assemblyGO:003133420.038
iron ion transportGO:000682640.037
regulation of transcription from rna polymerase ii promoterGO:00063571140.037
response to external stimulusGO:00096052640.036
actin filament polymerizationGO:003004120.036
regulation of cellular macromolecule biosynthetic processGO:20001122220.035
regulation of peptidyl tyrosine phosphorylationGO:005073010.035
erythrocyte developmentGO:0048821240.034
protein complex subunit organizationGO:0071822460.034
regulation of protein transportGO:005122330.034
regulation of response to biotic stimulusGO:000283120.034
cellular response to stressGO:0033554620.033
anterior posterior pattern specificationGO:00099521520.033
ion transportGO:00068111140.033
regulation of protein localization to nucleusGO:190018020.032
extrinsic apoptotic signaling pathwayGO:009719130.032
muscle cell differentiationGO:00426921390.032
determination of bilateral symmetryGO:00098552040.032
protein complex disassemblyGO:004324110.032
cellular component disassemblyGO:002241110.032
canonical wnt signaling pathwayGO:0060070480.032
response to ketoneGO:190165410.032
phosphate containing compound metabolic processGO:00067961080.032
regulation of protein polymerizationGO:003227120.032
positive regulation of cellular processGO:00485222010.031
cellular iron ion homeostasisGO:000687930.031
porphyrin containing compound metabolic processGO:0006778100.031
protein polymerizationGO:005125840.030
hepaticobiliary system developmentGO:0061008980.030
negative regulation of dna metabolic processGO:005105340.030
actin polymerization or depolymerizationGO:000815420.029
positive regulation of macromolecule metabolic processGO:0010604930.029
regulation of rna biosynthetic processGO:20011412130.029
response to drugGO:004249330.029
cellular protein modification processGO:00064641000.029
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stressGO:007005930.029
cardiac atrium morphogenesisGO:000320920.029
macromolecular complex disassemblyGO:003298410.029
generation of neuronsGO:00486993850.028
ion homeostasisGO:0050801410.028
regulation of cellular biosynthetic processGO:00313262450.028
determination of heart left right asymmetryGO:00613711170.028
positive regulation of biological processGO:00485182530.028
regulation of ectodermal cell fate specificationGO:004266520.028
sequestering of metal ionGO:005123830.028
pathway restricted smad protein phosphorylationGO:006038910.027
cation homeostasisGO:0055080330.027
cellular transition metal ion homeostasisGO:004691630.027
organic cyclic compound metabolic processGO:19013603010.027
response to superoxideGO:000030320.027
cellular component assemblyGO:00226071700.027
sensory organ developmentGO:00074233930.026
positive regulation of programmed cell deathGO:0043068290.026
cellular component morphogenesisGO:00329893360.026
antimicrobial humoral responseGO:001973020.026
peptidyl threonine modificationGO:001821010.026
nuclear transportGO:005116940.026
single organism transportGO:00447652060.026
regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:200123910.026
regulation of cell proliferation involved in heart morphogenesisGO:200013620.025
heterocycle biosynthetic processGO:00181302150.025
regulation of nucleobase containing compound metabolic processGO:00192192500.025
regulation of bindingGO:005109830.024
regulation of developmental processGO:00507932470.024
embryonic cranial skeleton morphogenesisGO:0048701900.024
positive regulation of cell cycleGO:004578730.024
digestive tract developmentGO:00485652650.024
b cell activationGO:004211320.024
regulation of circadian sleep wake cycleGO:004274910.024
regulation of protein bindingGO:004339330.024
protein complex assemblyGO:0006461300.024
regulation of cytokine productionGO:000181730.024
positive regulation of cellular component biogenesisGO:004408930.024
regulation of cell communicationGO:00106462320.024
positive regulation of transcription dna templatedGO:0045893570.024
macromolecular complex subunit organizationGO:0043933740.023
toll like receptor signaling pathwayGO:000222440.023
wnt signaling pathwayGO:0016055800.023
single organism metabolic processGO:00447102170.023
regulation of blood vessel sizeGO:005088020.023
cell projection organizationGO:00300302840.023
ribosomal small subunit biogenesisGO:004227420.023
heart morphogenesisGO:00030071560.023
tissue remodelingGO:004877140.023
cellular response to lipopolysaccharideGO:007122230.023
regulation of rna metabolic processGO:00512522240.022
response to abiotic stimulusGO:00096281220.022
negative regulation of response to stimulusGO:00485851040.022
cardiac muscle tissue developmentGO:0048738480.022
translational initiationGO:000641330.022
endocrine processGO:005088620.022
dorsal ventral pattern formationGO:00099531250.022
cell fate commitmentGO:0045165990.022
negative regulation of cellular metabolic processGO:0031324770.022
mononuclear cell proliferationGO:003294310.022
growthGO:00400071740.022
regulation of blood pressureGO:000821710.022
protein acylationGO:004354330.022
negative regulation of nitrogen compound metabolic processGO:0051172590.022
heme biosynthetic processGO:000678380.022
embryonic heart tube morphogenesisGO:00031431080.021
cardiac atrium developmentGO:000323040.021
regulation of signal transductionGO:00099662250.021
muscle tissue developmentGO:00605371100.021
positive regulation of apoptotic signaling pathwayGO:200123510.021
negative regulation of biological processGO:00485193040.021
lymphocyte proliferationGO:004665110.021
establishment of protein localization to organelleGO:007259440.021
regulation of dna replicationGO:000627530.021
locomotionGO:00400113130.021
cell fate specificationGO:0001708680.021
cellular response to molecule of bacterial originGO:007121930.021
platelet formationGO:003022010.021
positive regulation of cell deathGO:0010942290.020
protein complex biogenesisGO:0070271300.020
positive regulation of catabolic processGO:000989640.020
mitotic cell cycleGO:0000278640.020
b cell differentiationGO:003018310.020
determination of left right symmetryGO:00073681790.020
response to glucocorticoidGO:005138410.019
response to inorganic substanceGO:0010035380.019
mitochondrion organizationGO:000700540.019
specification of symmetryGO:00097992040.019
system processGO:00030081850.019
gland developmentGO:00487321430.019
response to oxidative stressGO:0006979110.019
cell cycle g2 m phase transitionGO:004483940.019
cell migration involved in gastrulationGO:0042074790.019
lamellipodium organizationGO:009758110.019
regulation of nitrogen compound metabolic processGO:00511712510.019
cell substrate junction assemblyGO:000704420.019
regulation of protein modification by small protein conjugation or removalGO:190332030.019
mitochondrial transportGO:000683920.019
internal protein amino acid acetylationGO:000647520.019
morphogenesis of an epitheliumGO:00020093330.019
regulation of molecular functionGO:0065009700.019
positive regulation of cytosolic calcium ion concentrationGO:000720440.018
tetrapyrrole metabolic processGO:0033013100.018
response to uvGO:000941130.018
protein modification processGO:00362111000.018
adherens junction organizationGO:003433240.018
response to other organismGO:0051707970.018
cell morphogenesis involved in differentiationGO:00009041950.018
positive regulation of cellular catabolic processGO:003133130.018
response to reactive oxygen speciesGO:000030250.018
regulation of cellular carbohydrate metabolic processGO:001067540.018
cation transportGO:0006812810.018
cellular protein complex disassemblyGO:004362410.018
cellular nitrogen compound biosynthetic processGO:00442712180.018
cellular carbohydrate metabolic processGO:004426240.017
nuclear importGO:005117030.017
striated muscle tissue developmentGO:00147061100.017
regulation of circadian rhythmGO:004275240.017
negative regulation of sequence specific dna binding transcription factor activityGO:004343320.017
transition metal ion transportGO:000004160.017
regulation of cellular response to oxidative stressGO:190040720.017
phosphorylationGO:0016310690.017
g2 m transition of mitotic cell cycleGO:000008640.017
compound eye developmentGO:004874920.017
cell death in response to oxidative stressGO:003647320.017
response to nutrientGO:000758430.017
regulation of multicellular organismal processGO:00512392770.017
cellular cation homeostasisGO:0030003170.017
cell deathGO:00082191210.017
regulation of tissue remodelingGO:003410320.017
positive regulation of secretion by cellGO:190353210.017
regulation of cellular amino acid metabolic processGO:000652100.016
protein acetylationGO:000647320.016
negative regulation of protein import into nucleusGO:004230820.016
positive regulation of cytoskeleton organizationGO:005149530.016
cellular monovalent inorganic cation homeostasisGO:003000420.016
positive regulation of translationGO:004572710.016
positive regulation of gene expressionGO:0010628710.016
mitotic dna integrity checkpointGO:004477440.016
striated muscle cell differentiationGO:00511461290.016
positive regulation of muscle cell differentiationGO:005114910.016
regulation of phosphorus metabolic processGO:0051174430.016
regulation of protein import into nucleusGO:004230620.016
internal peptidyl lysine acetylationGO:001839320.016
small molecule metabolic processGO:0044281770.016
negative regulation of developmental processGO:0051093650.016
ventricular cardiac muscle tissue developmentGO:000322930.016
regulation of cellular amine metabolic processGO:003323800.016
cofactor metabolic processGO:0051186150.015
female gonad developmentGO:000858540.015
blood circulationGO:0008015870.015
heart processGO:0003015710.015
heart contractionGO:0060047710.015
urogenital system developmentGO:0001655970.015
cytokinesisGO:000091030.015
regulation of chromosome segregationGO:005198310.015
enzyme linked receptor protein signaling pathwayGO:00071671060.015
cell cycle arrestGO:000705010.015
regulation of carbohydrate metabolic processGO:000610940.015
establishment of blood brain barrierGO:006085620.015
protein importGO:001703830.015
protein import into nucleusGO:000660630.015
peptidyl threonine phosphorylationGO:001810710.015
development of primary female sexual characteristicsGO:004654540.015
response to chemicalGO:00422213200.015
regulation of blood coagulationGO:003019310.015
regulation of protein metabolic processGO:0051246560.015
positive regulation of peptidyl tyrosine phosphorylationGO:005073110.015
positive regulation of apoptotic processGO:0043065290.015
microtubule polymerizationGO:004678520.015
rna localizationGO:000640340.015
segmentationGO:0035282970.015
maturation of ssu rrnaGO:003049010.015
astrocyte differentiationGO:004870810.014
protein targeting to nucleusGO:004474430.014
hematopoietic stem cell migrationGO:003570140.014
microtubule polymerization or depolymerizationGO:003110930.014
pancreas developmentGO:0031016840.014
regulation of production of molecular mediator of immune responseGO:000270010.014
intermediate mesoderm developmentGO:004838920.014
response to monosaccharideGO:003428430.014
peptidyl lysine acetylationGO:001839420.014
positive regulation of nucleobase containing compound metabolic processGO:0045935690.014
regulation of cytoplasmic transportGO:190364940.014
sequestering of calcium ionGO:005120830.014
mitotic dna damage checkpointGO:004477340.014
developmental maturationGO:0021700340.014
cellular response to chemical stimulusGO:00708871570.014
positive regulation of map kinase activityGO:004340630.014
cytoskeleton dependent cytokinesisGO:006164030.014
intracellular signal transductionGO:0035556850.014
stem cell maintenanceGO:001982740.014
negative regulation of epithelial cell proliferationGO:005068010.014
brain developmentGO:00074202930.014
protein secretionGO:000930610.014
endoderm formationGO:0001706290.014
protein depolymerizationGO:005126110.014
regulation of multicellular organismal developmentGO:20000262230.014
leukocyte proliferationGO:007066110.014
regulation of tube sizeGO:003515020.014
centrosome cycleGO:000709810.014
protein stabilizationGO:005082120.014
release of sequestered calcium ion into cytosolGO:005120930.014
regulation of cellular ketone metabolic processGO:001056570.014
nitric oxide metabolic processGO:004620920.014
myeloid leukocyte differentiationGO:0002573150.013
regulation of postsynaptic membrane potentialGO:006007810.013
regulation of protein catabolic processGO:004217610.013
microtubule organizing center organizationGO:003102310.013
cellular chemical homeostasisGO:0055082170.013
regulation of protein ubiquitinationGO:003139630.013
cell fate commitment involved in formation of primary germ layerGO:0060795260.013
regulation of translational initiationGO:000644610.013
negative regulation of apoptotic processGO:0043066550.013
regulation of ectoderm developmentGO:200038320.013
metal ion transportGO:0030001580.013
peptide transportGO:001583310.013
dna templated transcription elongationGO:000635430.013
negative regulation of gene expressionGO:0010629650.013
negative regulation of wnt signaling pathwayGO:0030178300.013
regulation of cardiac muscle cell differentiationGO:200072510.013
regionalizationGO:00030022740.013
positive regulation of cellular metabolic processGO:0031325940.013
regulation of cell differentiationGO:00455951420.013
positive regulation of cellular amino acid metabolic processGO:004576400.013
nephron epithelium morphogenesisGO:007208810.013
regulation of dna templated transcription in response to stressGO:004362000.013
retina vasculature development in camera type eyeGO:006129820.013
regulation of multicellular organism growthGO:004001440.013
negative regulation of leukocyte differentiationGO:190210610.013
centrosome organizationGO:005129710.013
regulation of phosphate metabolic processGO:0019220430.013
gastrulation with mouth forming secondGO:0001702440.012
response to coldGO:000940940.012
superoxide metabolic processGO:000680120.012
regulation of wnt signaling pathwayGO:0030111530.012
negative regulation of signal transductionGO:0009968940.012
neuron differentiationGO:00301823530.012
erk1 and erk2 cascadeGO:007037140.012
cell motilityGO:00488702440.012
regulation of protein complex disassemblyGO:004324410.012
determination of left right asymmetry in nervous systemGO:003554540.012
response to biotic stimulusGO:0009607970.012
negative regulation of secretionGO:005104820.012
meiotic nuclear divisionGO:000712640.012
regulation of sequestering of calcium ionGO:005128240.012
metal ion homeostasisGO:0055065260.012
removal of superoxide radicalsGO:001943020.012
somatic stem cell maintenanceGO:003501910.012
positive regulation of multicellular organismal processGO:0051240520.012
circadian sleep wake cycleGO:004274520.012
cellular localizationGO:0051641970.012
positive regulation of protein polymerizationGO:003227320.012
negative regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:200124010.012
localization of cellGO:00516742440.012
regulation of catalytic activityGO:0050790550.012
positive regulation of lymphocyte mediated immunityGO:000270810.012
tissue regenerationGO:0042246740.012
negative regulation of extrinsic apoptotic signaling pathwayGO:200123720.012
cognitionGO:005089010.012
cell projection morphogenesisGO:00488582440.012
nucleobase containing compound metabolic processGO:00061392740.012
cellular ketone metabolic processGO:0042180110.012
positive regulation of chromosome organizationGO:200125210.012
gas transportGO:001566930.011
negative regulation of nucleic acid templated transcriptionGO:1903507450.011
embryo development ending in birth or egg hatchingGO:00097922710.011
cell morphogenesisGO:00009022890.011
proepicardium developmentGO:000334240.011
female sex differentiationGO:004666040.011
regulation of protein depolymerizationGO:190187910.011
chemical homeostasisGO:0048878490.011
phagocytosisGO:000690930.011
positive regulation of molecular functionGO:0044093330.011
protein homooligomerizationGO:005126030.011
muscle cell developmentGO:00550011150.011
negative regulation of signalingGO:0023057960.011
positive regulation of cell communicationGO:0010647560.011
cell migrationGO:00164772370.011
positive regulation of transcription elongation from rna polymerase ii promoterGO:003296810.011
morphogenesis of an epithelial foldGO:006057110.011
skeletal system developmentGO:00015011810.011
cardiac muscle fiber developmentGO:004873930.011
definitive hemopoiesisGO:0060216180.011
negative regulation of signal transduction in absence of ligandGO:190109910.011
dipeptide transportGO:004293810.011
cell cell signalingGO:0007267520.011
reactive oxygen species metabolic processGO:007259360.011
macromolecular complex assemblyGO:0065003350.011
positive regulation of cell activationGO:005086710.011
response to corticosteroidGO:003196010.011
cellular response to oxygen levelsGO:007145310.011
phosphorus metabolic processGO:00067931090.011
macromolecule modificationGO:00434121110.011
determination of dorsal identityGO:0048263130.011
regulation of nucleocytoplasmic transportGO:004682220.011
calcium ion transport into cytosolGO:006040230.011
bone remodelingGO:004684920.011
bicarbonate transportGO:001570140.011
positive regulation of response to stimulusGO:0048584800.011
positive regulation of rna biosynthetic processGO:1902680570.010
carbohydrate derivative metabolic processGO:1901135610.010
cytoplasm organizationGO:000702840.010
regulation of cell deathGO:00109411030.010
amine metabolic processGO:000930820.010
single organism nuclear importGO:190259330.010
single organism biosynthetic processGO:0044711710.010
positive regulation of nitrogen compound metabolic processGO:0051173690.010
regulation of response to external stimulusGO:0032101310.010
production of molecular mediator of immune responseGO:000244020.010
regulation of mrna processingGO:005068430.010
positive regulation of transportGO:005105020.010
oxoacid metabolic processGO:0043436310.010
regulation of protein phosphorylationGO:0001932180.010
synaptic growth at neuromuscular junctionGO:005112420.010
regulation of intracellular phGO:005145310.010
hatchingGO:003518840.010
regulation of transcription elongation from rna polymerase ii promoterGO:003424330.010
mitotic g2 m transition checkpointGO:004481830.010
nucleic acid transportGO:005065720.010
spermatid differentiationGO:004851520.010
embryonic organ morphogenesisGO:00485622740.010

hmbsb disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of cellular proliferationDOID:1456600.141
cancerDOID:16200.141
organ system cancerDOID:005068600.125
disease of anatomical entityDOID:700.049
musculoskeletal system diseaseDOID:1700.017
disease of metabolismDOID:001466700.016
muscular diseaseDOID:008000000.014
cardiovascular system diseaseDOID:128700.010