Danio rerio

42 known processes

pkp2

plakophilin 2

(Aliases: si:ch211-11c20.1)

pkp2 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
digestive tract morphogenesisGO:00485462310.304
signal transductionGO:00071654550.231
regulation of synapse organizationGO:005080730.223
cell motilityGO:00488702440.208
nuclear migrationGO:000709730.204
transportGO:00068102200.201
localization of cellGO:00516742440.200
embryonic organ morphogenesisGO:00485622740.165
axon developmentGO:00615641660.165
proteolysis involved in cellular protein catabolic processGO:005160330.164
ameboidal type cell migrationGO:00016671430.157
cell migrationGO:00164772370.152
regulation of biological qualityGO:00650082630.152
Human
morphogenesis of an epitheliumGO:00020093330.151
embryonic organ developmentGO:00485683810.150
head developmentGO:00603223030.150
brain developmentGO:00074202930.149
regulation of response to stimulusGO:00485832690.149
regulation of synapse assemblyGO:005196330.141
regulation of cellular component organizationGO:0051128860.138
Worm
locomotionGO:00400113130.135
cellular component movementGO:00069283350.132
single organism transportGO:00447652060.125
gastrulationGO:00073692080.113
central nervous system developmentGO:00074173870.111
cellular component morphogenesisGO:00329893360.109
cell projection morphogenesisGO:00488582440.108
negative regulation of cellular processGO:00485232830.106
Human
digestive system developmentGO:00551232890.104
transmembrane transportGO:00550851200.101
proteasome mediated ubiquitin dependent protein catabolic processGO:004316120.099
cell surface receptor signaling pathwayGO:00071663250.098
cell morphogenesisGO:00009022890.096
negative regulation of biological processGO:00485193040.095
Human
cell morphogenesis involved in differentiationGO:00009041950.095
cellular protein catabolic processGO:004425740.090
positive regulation of cellular component biogenesisGO:004408930.089
response to external stimulusGO:00096052640.089
actin cytoskeleton organizationGO:0030036630.086
Worm
regulation of developmental processGO:00507932470.085
Human
establishment of localizationGO:00512342440.083
sensory perception of chemical stimulusGO:000760630.083
regulation of primary metabolic processGO:00800903110.081
inorganic ion transmembrane transportGO:0098660570.081
digestive tract developmentGO:00485652650.078
epithelial tube morphogenesisGO:00605621480.076
heart developmentGO:00075073130.076
specification of symmetryGO:00097992040.076
sensory organ developmentGO:00074233930.075
ubiquitin dependent protein catabolic processGO:000651130.075
modification dependent macromolecule catabolic processGO:004363230.073
negative regulation of protein phosphorylationGO:000193340.073
larval developmentGO:000216420.072
system processGO:00030081850.072
Human
organelle assemblyGO:00709251100.071
single organism localizationGO:19025782250.070
organic cyclic compound metabolic processGO:19013603010.069
regulation of cell deathGO:00109411030.069
regulation of multicellular organismal developmentGO:20000262230.067
cognitionGO:005089010.066
intracellular signal transductionGO:0035556850.065
gene expressionGO:00104672520.063
regulation of cell communicationGO:00106462320.063
cell part morphogenesisGO:00329902460.063
establishment of organelle localizationGO:0051656450.063
cellular component biogenesisGO:00440851780.063
Human
regulation of establishment of protein localizationGO:007020140.062
cellular localizationGO:0051641970.062
actin polymerization or depolymerizationGO:000815420.061
neuron projection developmentGO:00311751800.061
maintenance of locationGO:005123540.060
response to stressGO:00069502630.059
regulation of circadian rhythmGO:004275240.059
regulation of anatomical structure morphogenesisGO:00226031300.059
glucose importGO:004632320.058
negative regulation of small gtpase mediated signal transductionGO:005105810.057
regulation of multicellular organism growthGO:004001440.056
vasculature developmentGO:00019442780.055
autophagyGO:000691440.055
regulation of cell shapeGO:000836010.054
programmed cell deathGO:00125011190.054
regulation of macromolecule biosynthetic processGO:00105562250.053
actin filament based processGO:0030029640.053
Worm
regulation of localizationGO:00328791040.050
Human Worm
stem cell proliferationGO:007208940.050
regulation of programmed cell deathGO:00430671010.050
cellular nitrogen compound metabolic processGO:00346412900.049
regulation of cellular component sizeGO:0032535300.049
protein polymerizationGO:005125840.049
nitrogen compound metabolic processGO:00068073190.049
gtp catabolic processGO:000618420.049
actin filament polymerizationGO:003004120.048
positive regulation of cytosolic calcium ion concentrationGO:000720440.048
establishment or maintenance of polarity of embryonic epitheliumGO:001633220.048
heterocycle metabolic processGO:00464832900.048
neurotransmitter transportGO:000683620.047
neuron differentiationGO:00301823530.047
positive regulation of biological processGO:00485182530.047
single organism cellular localizationGO:1902580460.047
neuron projection morphogenesisGO:00488121610.047
negative regulation of protein kinase activityGO:000646940.046
regulation of signal transductionGO:00099662250.046
regulation of gene expressionGO:00104682650.046
tube morphogenesisGO:00352393490.045
organelle organizationGO:00069962270.045
Human Worm
regulation of rna biosynthetic processGO:20011412130.045
modification dependent protein catabolic processGO:001994130.045
adherens junction organizationGO:003433240.045
cellular nitrogen compound biosynthetic processGO:00442712180.044
ion transportGO:00068111140.044
adult behaviorGO:003053420.044
determination of heart left right asymmetryGO:00613711170.044
generation of neuronsGO:00486993850.044
regulation of protein transportGO:005122330.043
sprouting angiogenesisGO:0002040530.043
regulation of neurogenesisGO:0050767870.043
regulation of nucleocytoplasmic transportGO:004682220.043
organonitrogen compound metabolic processGO:1901564740.042
single organism metabolic processGO:00447102170.042
regulation of multicellular organismal processGO:00512392770.042
Human
developmental growth involved in morphogenesisGO:0060560860.042
regulation of protein catabolic processGO:004217610.042
proteasomal protein catabolic processGO:001049820.042
determination of left right symmetryGO:00073681790.040
positive regulation of secretion by cellGO:190353210.040
positive regulation of dna metabolic processGO:005105410.039
neurological system processGO:0050877620.039
guanosine containing compound metabolic processGO:190106840.039
multicellular organism growthGO:003526440.039
cellular amine metabolic processGO:004410620.039
developmental growthGO:00485891660.039
positive regulation of transportGO:005105020.039
regulation of cellular metabolic processGO:00313233200.038
protein localization to plasma membraneGO:007265910.038
cellular macromolecule metabolic processGO:00442603910.037
multicellular organismal homeostasisGO:0048871290.037
apoptotic process involved in developmentGO:190274220.037
g1 s transition of mitotic cell cycleGO:000008210.037
nucleobase containing compound metabolic processGO:00061392740.037
protein localization to nucleusGO:003450430.036
gtp metabolic processGO:004603940.036
deathGO:00162651210.036
single organism organelle organizationGO:19025891990.036
Human Worm
regulation of cellular biosynthetic processGO:00313262450.036
regulation of apoptotic processGO:0042981980.035
establishment of localization in cellGO:0051649770.035
determination of bilateral symmetryGO:00098552040.035
cell deathGO:00082191210.035
response to chemicalGO:00422213200.035
organelle fusionGO:004828430.034
inorganic cation transmembrane transportGO:0098662500.034
guanosine containing compound catabolic processGO:190106920.034
regulation of extent of cell growthGO:0061387290.034
multi organism processGO:00517041340.034
regulation of cytoplasmic transportGO:190364940.034
growthGO:00400071740.034
synaptic growth at neuromuscular junctionGO:005112420.033
positive regulation of programmed cell deathGO:0043068290.033
developmental cell growthGO:0048588520.033
regulation of metal ion transportGO:001095940.033
neuron developmentGO:00486662620.032
stem cell maintenanceGO:001982740.032
erk1 and erk2 cascadeGO:007037140.032
regulation of signalingGO:00230512350.032
negative regulation of response to stimulusGO:00485851040.032
negative regulation of ras protein signal transductionGO:004658010.031
phosphorus metabolic processGO:00067931090.031
regulation of protein import into nucleusGO:004230620.031
heart loopingGO:0001947940.031
blood circulationGO:0008015870.031
Human
cell migration involved in gastrulationGO:0042074790.031
blood vessel endothelial cell migrationGO:0043534180.031
neuromuscular synaptic transmissionGO:000727420.031
ras protein signal transductionGO:000726570.031
nucleic acid templated transcriptionGO:00976591810.030
rna metabolic processGO:00160702190.030
apical junction assemblyGO:004329710.030
regulation of cell morphogenesisGO:0022604420.030
small gtpase mediated signal transductionGO:000726480.030
cell growthGO:0016049570.030
regulation of wound healingGO:006104120.030
behaviorGO:0007610740.030
fertilizationGO:000956630.030
amine metabolic processGO:000930820.030
positive regulation of exocytosisGO:004592110.030
positive regulation of cell cycleGO:004578730.029
angiogenesisGO:00015251580.029
chordate embryonic developmentGO:00430092710.029
response to organic substanceGO:00100331530.029
regulation of cell activationGO:005086510.029
positive regulation of immune effector processGO:000269930.029
protein localizationGO:0008104400.029
Worm
cellular component assemblyGO:00226071700.029
Human
regulation of macromolecule metabolic processGO:00602553170.029
cell proliferationGO:0008283800.029
neuroblast proliferationGO:000740520.029
cell cycle g1 s phase transitionGO:004484310.028
rho protein signal transductionGO:000726650.028
positive regulation of erk1 and erk2 cascadeGO:007037420.028
meiotic cell cycle processGO:190304630.028
homeostatic processGO:00425921420.027
epithelial cell migrationGO:0010631250.027
agingGO:000756820.027
renal system developmentGO:0072001940.027
regulation of cellular macromolecule biosynthetic processGO:20001122220.027
cell morphogenesis involved in neuron differentiationGO:00486671630.027
nucleic acid transportGO:005065720.027
regulation of protein complex assemblyGO:004325430.027
negative regulation of signal transductionGO:0009968940.027
ion transmembrane transportGO:0034220910.026
response to uvGO:000941130.026
protein complex localizationGO:003150310.026
cortical actin cytoskeleton organizationGO:003086610.026
cellular response to external stimulusGO:007149620.026
regulation of tube sizeGO:003515020.026
regulation of neuron projection developmentGO:0010975400.026
exocytosisGO:000688710.026
regulation of protein localization to nucleusGO:190018020.026
organic substance biosynthetic processGO:19015762890.026
embryonic skeletal system developmentGO:0048706970.026
sensory perceptionGO:0007600390.025
regulation of protein polymerizationGO:003227120.025
regulation of erk1 and erk2 cascadeGO:007037240.025
convergent extensionGO:00600261180.025
regulation of cell differentiationGO:00455951420.025
Human
phagocytosisGO:000690930.025
smooth muscle contractionGO:000693920.025
small molecule metabolic processGO:0044281770.024
meiotic nuclear divisionGO:000712640.024
nuclear transportGO:005116940.024
phosphate containing compound metabolic processGO:00067961080.024
regulation of establishment of planar polarityGO:009017540.024
regulation of nucleobase containing compound metabolic processGO:00192192500.024
rna biosynthetic processGO:00327741810.024
positive regulation of cellular catabolic processGO:003133130.024
regulation of cell migrationGO:0030334400.024
nucleic acid metabolic processGO:00903042440.024
nuclear importGO:005117030.024
regulation of cellular amino acid metabolic processGO:000652100.024
macromolecule modificationGO:00434121110.023
g protein coupled receptor signaling pathwayGO:0007186740.023
negative regulation of cell communicationGO:0010648960.023
axon guidanceGO:0007411860.023
germ line stem cell divisionGO:004207810.023
regulation of neuron differentiationGO:0045664560.023
apoptotic processGO:00069151160.023
establishment or maintenance of cell polarityGO:0007163290.023
cellular protein modification processGO:00064641000.022
macromolecule biosynthetic processGO:00090592270.022
homophilic cell adhesion via plasma membrane adhesion moleculesGO:000715640.022
ear developmentGO:00435831270.022
cellular aromatic compound metabolic processGO:00067252950.022
adherens junction maintenanceGO:003433420.022
biosynthetic processGO:00090582940.022
regulation of transcription dna templatedGO:00063552130.022
positive regulation of cysteine type endopeptidase activity involved in apoptotic processGO:0043280100.022
protein import into nucleusGO:000660630.022
regulation of exocytosisGO:001715710.022
membrane fusionGO:006102520.021
regulation of metabolic processGO:00192223590.021
macromolecule catabolic processGO:0009057150.021
regulation of cell projection organizationGO:0031344440.021
positive regulation of muscle organ developmentGO:004863610.021
immune system processGO:00023762410.021
lipid storageGO:001991510.021
cellular component assembly involved in morphogenesisGO:00109271070.021
positive regulation of muscle cell differentiationGO:005114910.021
regulation of molecular functionGO:0065009700.021
organic cyclic compound biosynthetic processGO:19013622230.021
blood vessel developmentGO:00015682460.021
positive regulation of macromolecule metabolic processGO:0010604930.021
regulation of synaptic growth at neuromuscular junctionGO:000858210.021
chemical homeostasisGO:0048878490.021
embryonic heart tube developmentGO:00350501330.021
positive regulation of secretionGO:005104710.020
cytokinesisGO:000091030.020
nucleus localizationGO:005164780.020
protein targeting to nucleusGO:004474430.020
positive regulation of stress activated protein kinase signaling cascadeGO:007030430.020
positive regulation of protein complex assemblyGO:003133420.020
regulation of cellular amine metabolic processGO:003323800.020
carboxylic acid metabolic processGO:0019752220.020
regulation of dna replicationGO:000627530.020
hemopoiesisGO:00300971830.020
mitotic dna integrity checkpointGO:004477440.020
regulation of reproductive processGO:200024140.020
organic acid metabolic processGO:0006082310.020
cellular response to extracellular stimulusGO:003166820.020
eye developmentGO:00016542770.020
negative regulation of kinase activityGO:003367340.019
single fertilizationGO:000733830.019
cell adhesionGO:0007155400.019
Mouse
regulation of cell morphogenesis involved in differentiationGO:0010769380.019
transcription from rna polymerase ii promoterGO:0006366800.019
oocyte maturationGO:000155640.019
protein secretionGO:000930610.019
nucleoside monophosphate catabolic processGO:000912540.019
regulation of neurotransmitter transportGO:005158810.019
positive regulation of apoptotic signaling pathwayGO:200123510.019
organ formationGO:0048645170.019
regulation of catalytic activityGO:0050790550.019
regulation of production of molecular mediator of immune responseGO:000270010.019
circadian regulation of gene expressionGO:003292280.019
protein modification processGO:00362111000.019
meiosis iGO:000712710.019
negative regulation of nuclear divisionGO:005178430.019
regulation of filopodium assemblyGO:005148920.019
segment polarity determinationGO:000736710.019
regulation of organ morphogenesisGO:2000027350.019
cellular macromolecular complex assemblyGO:0034622240.019
cell projection organizationGO:00300302840.019
regulation of cytokine productionGO:000181730.019
positive regulation of cellular metabolic processGO:0031325940.018
morphogenesis of an epithelial sheetGO:0002011490.018
cilium assemblyGO:0042384580.018
single organism intracellular transportGO:1902582250.018
digestive tract mesoderm developmentGO:000750210.018
regulation of nucleotide catabolic processGO:003081120.018
phosphorylationGO:0016310690.018
regulation of cellular ketone metabolic processGO:001056570.018
cellular macromolecule biosynthetic processGO:00346452240.018
membrane organizationGO:0061024210.018
blood vessel morphogenesisGO:00485142160.018
inner ear developmentGO:00488391260.018
release of sequestered calcium ion into cytosolGO:005120930.018
regulation of embryonic developmentGO:0045995470.018
cation transmembrane transportGO:0098655650.018
establishment or maintenance of epithelial cell apical basal polarityGO:0045197110.018
developmental programmed cell deathGO:001062340.018
positive regulation of signalingGO:0023056560.018
muscle cell differentiationGO:00426921390.018
regulation of peptidyl tyrosine phosphorylationGO:005073010.018
regulation of cell developmentGO:00602841000.018
nucleobase containing compound biosynthetic processGO:00346542050.018
rna 3 end processingGO:003112320.018
embryonic digestive tract morphogenesisGO:004855730.017
oxoacid metabolic processGO:0043436310.017
regulation of intracellular protein transportGO:003315730.017
regulation of actin cytoskeleton organizationGO:003295680.017
Worm
regulation of glucose importGO:004632410.017
regionalizationGO:00030022740.017
protein metabolic processGO:00195381830.017
lateral inhibitionGO:004633110.017
neuron projection guidanceGO:0097485860.017
negative regulation of epithelial cell proliferationGO:005068010.017
keratinocyte differentiationGO:003021600.017
positive regulation of metabolic processGO:00098931080.017
establishment of protein localization to organelleGO:007259440.017
heterocycle biosynthetic processGO:00181302150.017
cellular biosynthetic processGO:00442492860.017
negative regulation of mapk cascadeGO:004340940.017
rna localizationGO:000640340.017
peptide transportGO:001583310.017
water homeostasisGO:003010440.016
establishment of nucleus localizationGO:004002370.016
cell substrate adhesionGO:003158940.016
convergent extension involved in gastrulationGO:0060027710.016
regulation of cell projection assemblyGO:006049140.016
transcription dna templatedGO:00063511810.016
positive regulation of cell adhesionGO:004578510.016
purine nucleoside monophosphate catabolic processGO:000912840.016
regulation of nitrogen compound metabolic processGO:00511712510.016
positive regulation of cell divisionGO:005178120.016
negative regulation of signalingGO:0023057960.016
locomotor rhythmGO:004547530.016
kidney developmentGO:0001822920.016
single organism membrane organizationGO:0044802200.016
axonogenesisGO:00074091520.016
regulation of response to biotic stimulusGO:000283120.016
regulation of stem cell differentiationGO:200073640.016
establishment or maintenance of apical basal cell polarityGO:0035088120.016
regulation of rna metabolic processGO:00512522240.016
macromolecular complex assemblyGO:0065003350.016
atp catabolic processGO:000620040.016
negative regulation of defense responseGO:003134820.016
peptidyl serine modificationGO:001820920.015
periodic partitioningGO:000736510.015
cytoskeleton organizationGO:0007010960.015
Human Worm
positive regulation of cellular amine metabolic processGO:003324000.015
single organism membrane fusionGO:004480120.015
negative regulation of gene expressionGO:0010629650.015
protein heterooligomerizationGO:005129110.015
regulation of mitosisGO:000708890.015
taxisGO:00423301090.015
chemotaxisGO:00069351040.015
regulation of blood coagulationGO:003019310.015
mitotic nuclear divisionGO:0007067180.015
regulation of cytoskeleton organizationGO:0051493110.015
Worm
regulation of transmembrane transporter activityGO:002289820.015
mitotic dna damage checkpointGO:004477340.015
negative regulation of protein serine threonine kinase activityGO:007190120.015
i kappab kinase nf kappab signalingGO:000724940.015
regulation of cell proliferationGO:0042127370.015
regulation of blood pressureGO:000821710.015
response to oxygen containing compoundGO:1901700550.015
membrane invaginationGO:001032410.015
regulation of organ growthGO:004662030.015
calcium ion transport into cytosolGO:006040230.015
cell projection assemblyGO:0030031640.015
establishment or maintenance of bipolar cell polarityGO:0061245120.015
positive regulation of cytokine productionGO:000181920.015
positive regulation of production of molecular mediator of immune responseGO:000270210.015
regulation of chromosome segregationGO:005198310.015
organelle localizationGO:0051640490.015
cell junction organizationGO:0034330110.015
cellular ketone metabolic processGO:0042180110.014
axon extensionGO:0048675450.014
regulation of heart growthGO:006042020.014
circulatory system processGO:0003013870.014
Human
gland developmentGO:00487321430.014
g2 dna damage checkpointGO:003157230.014
chemosensory behaviorGO:000763510.014
muscle tissue developmentGO:00605371100.014
Human
cellular amino acid metabolic processGO:000652070.014
nucleocytoplasmic transportGO:000691340.014
regulation of protein metabolic processGO:0051246560.014
regulation of nucleoside metabolic processGO:000911820.014
tube closureGO:006060610.014
spermatid differentiationGO:004851520.014
cell killingGO:000190620.014
regulation of cellular component movementGO:0051270550.014
Human
negative regulation of apoptotic processGO:0043066550.014
phagocytosis engulfmentGO:000691110.014
regulation of blood vessel sizeGO:005088020.014
calcium ion importGO:007050940.014
kupffer s vesicle developmentGO:0070121500.014
positive regulation of response to stimulusGO:0048584800.014
response to biotic stimulusGO:0009607970.014
stem cell divisionGO:001714510.014
regulation of i kappab kinase nf kappab signalingGO:004312240.014
aromatic compound biosynthetic processGO:00194382170.014
mitotic cell cycle processGO:1903047480.014
regulation of gtp catabolic processGO:003312420.014
regulation of cellular protein catabolic processGO:190336210.014
positive regulation of gene expressionGO:0010628710.014
macromolecular complex subunit organizationGO:0043933740.013
Human
positive regulation of cell activationGO:005086710.013
antimicrobial humoral responseGO:001973020.013
regulation of nucleic acid templated transcriptionGO:19035062130.013
embryo development ending in birth or egg hatchingGO:00097922710.013
cellular response to starvationGO:000926710.013
peripheral nervous system neuron developmentGO:0048935220.013
regulation of proteolysis involved in cellular protein catabolic processGO:190305010.013
wound healingGO:0042060900.013
negative regulation of molecular functionGO:0044092230.013
centrosome localizationGO:005164210.013
positive regulation of leukocyte mediated immunityGO:000270510.013
regulation of protein targetingGO:190353320.013
regulation of intracellular signal transductionGO:1902531570.013
response to carbohydrateGO:000974330.013
regulation of oocyte developmentGO:006028130.013
striated muscle tissue developmentGO:00147061100.013
Human
positive regulation of cell deathGO:0010942290.013
mitochondrion organizationGO:000700540.013
hindbrain developmentGO:0030902910.013
synaptic transmission cholinergicGO:000727140.013
cellular response to nutrient levelsGO:003166920.013
transmembrane receptor protein serine threonine kinase signaling pathwayGO:0007178680.013
secondary metabolic processGO:001974830.013
ion homeostasisGO:0050801410.013
regulation of epithelial cell proliferationGO:005067830.012
maintenance of cell polarityGO:003001150.012
regulation of ion transmembrane transporter activityGO:003241220.012
positive regulation of catabolic processGO:000989640.012
oocyte anterior posterior axis specificationGO:000731440.012
compound eye developmentGO:004874920.012
heart morphogenesisGO:00030071560.012
purine ribonucleoside monophosphate catabolic processGO:000916940.012
wnt signaling pathway planar cell polarity pathwayGO:006007140.012
tissue migrationGO:0090130370.012
sensory organ morphogenesisGO:00905962000.012
positive regulation of cellular amino acid metabolic processGO:004576400.012
regulation of cell motilityGO:2000145460.012
protein importGO:001703830.012
regulation of mrna catabolic processGO:006101330.012
regulation of bmp signaling pathwayGO:0030510390.012
odontogenesis of dentin containing toothGO:004247510.012
cellular response to chemical stimulusGO:00708871570.012
negative regulation of sequence specific dna binding transcription factor activityGO:004343320.012
peptidyl serine phosphorylationGO:001810510.012
positive regulation of apoptotic processGO:0043065290.012
regulation of glucose transportGO:001082710.012
response to glucocorticoidGO:005138410.012
positive regulation of striated muscle cell differentiationGO:005115510.012
regulation of growthGO:0040008420.012
innate immune responseGO:0045087130.012
negative regulation of cell deathGO:0060548600.012
rna transportGO:005065820.012
regulation of neutrophil extravasationGO:200038910.012
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domainsGO:000246040.012
ribonucleoside monophosphate catabolic processGO:000915840.012

pkp2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.029
Human
musculoskeletal system diseaseDOID:1700.019
Human
muscular diseaseDOID:008000000.014
Human
muscle tissue diseaseDOID:6600.014
Human
disease of cellular proliferationDOID:1456600.014
cancerDOID:16200.014
organ system cancerDOID:005068600.013
myopathyDOID:42300.013
Human