Danio rerio

29 known processes

alk

anaplastic lymphoma kinase (Ki-1)

alk biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
cognitionGO:005089010.489
cellular nitrogen compound metabolic processGO:00346412900.357
immune system developmentGO:00025201910.339
aromatic compound biosynthetic processGO:00194382170.314
regulation of metabolic processGO:00192223590.285
positive regulation of biological processGO:00485182530.277
regulation of primary metabolic processGO:00800903110.267
cell surface receptor signaling pathwayGO:00071663250.258
signal transductionGO:00071654550.257
heterocycle metabolic processGO:00464832900.255
regulation of rna biosynthetic processGO:20011412130.223
biosynthetic processGO:00090582940.214
regulation of signal transductionGO:00099662250.209
nucleobase containing compound metabolic processGO:00061392740.204
digestive system developmentGO:00551232890.204
rna metabolic processGO:00160702190.197
regulation of nucleobase containing compound metabolic processGO:00192192500.194
negative regulation of biological processGO:00485193040.194
cellular component morphogenesisGO:00329893360.181
nitrogen compound metabolic processGO:00068073190.177
cellular macromolecule metabolic processGO:00442603910.175
cellular aromatic compound metabolic processGO:00067252950.167
organic substance biosynthetic processGO:19015762890.166
positive regulation of cellular processGO:00485222010.166
organic cyclic compound biosynthetic processGO:19013622230.165
regulation of cellular macromolecule biosynthetic processGO:20001122220.162
stem cell maintenanceGO:001982740.159
regulation of gene expressionGO:00104682650.158
response to external stimulusGO:00096052640.152
regulation of nitrogen compound metabolic processGO:00511712510.151
positive regulation of transportGO:005105020.149
cellular nitrogen compound biosynthetic processGO:00442712180.142
cellular component movementGO:00069283350.140
regionalizationGO:00030022740.139
regulation of macromolecule metabolic processGO:00602553170.138
cellular macromolecule biosynthetic processGO:00346452240.136
neurological system processGO:0050877620.135
locomotionGO:00400113130.130
negative regulation of cellular processGO:00485232830.130
organic cyclic compound metabolic processGO:19013603010.124
generation of neuronsGO:00486993850.123
head developmentGO:00603223030.123
gene expressionGO:00104672520.119
regulation of biosynthetic processGO:00098892500.119
regulation of nucleic acid templated transcriptionGO:19035062130.117
transcription dna templatedGO:00063511810.114
tube morphogenesisGO:00352393490.113
cellular biosynthetic processGO:00442492860.112
ameboidal type cell migrationGO:00016671430.111
rna biosynthetic processGO:00327741810.111
regulation of macromolecule biosynthetic processGO:00105562250.109
regulation of signalingGO:00230512350.106
larval developmentGO:000216420.105
immune system processGO:00023762410.105
mononuclear cell proliferationGO:003294310.102
hematopoietic or lymphoid organ developmentGO:00485341910.101
regulation of programmed cell deathGO:00430671010.101
heterocycle biosynthetic processGO:00181302150.101
regulation of multicellular organismal developmentGO:20000262230.100
enzyme linked receptor protein signaling pathwayGO:00071671060.100
cell projection organizationGO:00300302840.100
regulation of protein transportGO:005122330.099
sensory organ developmentGO:00074233930.099
cell deathGO:00082191210.097
regulation of cellular metabolic processGO:00313233200.097
localization of cellGO:00516742440.095
positive regulation of cellular biosynthetic processGO:0031328680.094
nucleic acid templated transcriptionGO:00976591810.094
digestive tract developmentGO:00485652650.093
regulation of transcription dna templatedGO:00063552130.092
morphogenesis of an epitheliumGO:00020093330.092
regulation of establishment of protein localizationGO:007020140.090
oxoacid metabolic processGO:0043436310.090
system processGO:00030081850.090
deathGO:00162651210.088
positive regulation of metabolic processGO:00098931080.088
nucleic acid metabolic processGO:00903042440.087
neuron differentiationGO:00301823530.086
regulation of inflammatory responseGO:005072720.085
regulation of cellular biosynthetic processGO:00313262450.085
regulation of peptidyl tyrosine phosphorylationGO:005073010.084
g protein coupled receptor signaling pathway coupled to cyclic nucleotide second messengerGO:000718750.084
organonitrogen compound metabolic processGO:1901564740.083
negative regulation of metabolic processGO:0009892860.083
nucleobase containing compound biosynthetic processGO:00346542050.083
regulation of developmental processGO:00507932470.082
cellular carbohydrate metabolic processGO:004426240.081
cell part morphogenesisGO:00329902460.080
negative regulation of protein kinase activityGO:000646940.079
digestive tract morphogenesisGO:00485462310.078
positive regulation of peptidyl tyrosine phosphorylationGO:005073110.077
cellular amino acid metabolic processGO:000652070.076
regulation of cellular amine metabolic processGO:003323800.076
eye developmentGO:00016542770.074
macromolecule biosynthetic processGO:00090592270.074
developmental growthGO:00485891660.074
protein secretionGO:000930610.073
amine metabolic processGO:000930820.072
brain developmentGO:00074202930.071
leukocyte proliferationGO:007066110.071
hemopoiesisGO:00300971830.071
positive regulation of nitrogen compound metabolic processGO:0051173690.071
positive regulation of cellular component biogenesisGO:004408930.071
small molecule metabolic processGO:0044281770.070
neuron projection developmentGO:00311751800.070
extrinsic apoptotic signaling pathwayGO:009719130.069
stem cell differentiationGO:00488631170.068
regulation of biological qualityGO:00650082630.068
regulation of response to stimulusGO:00485832690.067
regulation of cell communicationGO:00106462320.067
response to organic substanceGO:00100331530.066
protein localization to nucleusGO:003450430.066
response to chemicalGO:00422213200.066
cellular ketone metabolic processGO:0042180110.066
regulation of cellular amino acid metabolic processGO:000652100.065
single organism metabolic processGO:00447102170.064
negative regulation of response to stimulusGO:00485851040.064
cell projection morphogenesisGO:00488582440.064
germ line stem cell maintenanceGO:003071820.064
cellular amine metabolic processGO:004410620.063
growthGO:00400071740.063
compound eye developmentGO:004874920.063
periodic partitioningGO:000736510.063
negative regulation of multicellular organismal processGO:0051241690.062
production of molecular mediator of immune responseGO:000244020.062
regulation of apoptotic processGO:0042981980.062
transportGO:00068102200.062
cell morphogenesis involved in neuron differentiationGO:00486671630.062
positive regulation of cell cycleGO:004578730.061
regulation of multicellular organismal processGO:00512392770.061
positive regulation of cytosolic calcium ion concentrationGO:000720440.060
positive regulation of cellular amine metabolic processGO:003324000.060
lymphocyte proliferationGO:004665110.059
cell morphogenesisGO:00009022890.059
embryonic organ developmentGO:00485683810.059
positive regulation of map kinase activityGO:004340630.057
positive regulation of secretion by cellGO:190353210.057
organic acid metabolic processGO:0006082310.057
apoptotic processGO:00069151160.057
regulation of multicellular organismal metabolic processGO:004424620.056
cellular protein metabolic processGO:00442671290.056
programmed cell deathGO:00125011190.056
alpha amino acid metabolic processGO:190160530.056
positive regulation of immune system processGO:0002684170.054
regulation of rna metabolic processGO:00512522240.054
response to drugGO:004249330.053
sensory perception of smellGO:000760820.053
response to abiotic stimulusGO:00096281220.053
adult behaviorGO:003053420.053
regulation of cellular ketone metabolic processGO:001056570.052
positive regulation of catabolic processGO:000989640.052
segmentationGO:0035282970.052
response to carbohydrateGO:000974330.052
regulation of cell activationGO:005086510.052
positive regulation of response to stimulusGO:0048584800.052
antimicrobial humoral responseGO:001973020.052
muscle structure developmentGO:00610611960.051
positive regulation of secretionGO:005104710.051
central nervous system developmentGO:00074173870.050
b cell activationGO:004211320.050
response to stressGO:00069502630.050
regulation of neurogenesisGO:0050767870.049
homeostatic processGO:00425921420.049
phosphate containing compound metabolic processGO:00067961080.049
muscle cell differentiationGO:00426921390.048
heart developmentGO:00075073130.048
regulation of localizationGO:00328791040.048
chemosensory behaviorGO:000763510.048
regulation of wound healingGO:006104120.048
regulation of metal ion transportGO:001095940.048
positive regulation of cellular metabolic processGO:0031325940.048
regulation of ion transmembrane transporter activityGO:003241220.047
gtp metabolic processGO:004603940.047
chordate embryonic developmentGO:00430092710.047
positive regulation of signalingGO:0023056560.047
convergent extension involved in gastrulationGO:0060027710.046
regulation of cytokine productionGO:000181730.046
transcription from rna polymerase ii promoterGO:0006366800.046
phosphorus metabolic processGO:00067931090.045
carboxylic acid metabolic processGO:0019752220.045
regulation of molecular functionGO:0065009700.045
regulation of transporter activityGO:003240920.045
positive regulation of nucleic acid templated transcriptionGO:1903508570.045
erk1 and erk2 cascadeGO:007037140.044
agingGO:000756820.044
regulation of calcium ion transportGO:005192420.044
regulation of cell differentiationGO:00455951420.044
positive regulation of cellular catabolic processGO:003133130.044
multi organism processGO:00517041340.044
regulation of erk1 and erk2 cascadeGO:007037240.043
regulation of cell deathGO:00109411030.043
positive regulation of camp metabolic processGO:003081620.043
positive regulation of camp biosynthetic processGO:003081920.043
positive regulation of cell activationGO:005086710.043
cellular component assemblyGO:00226071700.043
cell motilityGO:00488702440.042
response to woundingGO:00096111160.042
regulation of cell developmentGO:00602841000.042
positive regulation of gene expressionGO:0010628710.042
multicellular organism growthGO:003526440.042
macromolecule modificationGO:00434121110.040
positive regulation of dna metabolic processGO:005105410.039
single organism localizationGO:19025782250.039
cellular response to organic substanceGO:00713101050.038
purine nucleotide biosynthetic processGO:0006164200.038
stem cell developmentGO:0048864820.038
muscle organ developmentGO:00075171010.037
cellular modified amino acid metabolic processGO:000657530.037
positive regulation of macromolecule metabolic processGO:0010604930.037
endocrine processGO:005088620.037
neuron developmentGO:00486662620.037
cellular response to lipopolysaccharideGO:007122230.036
cellular response to molecule of bacterial originGO:007121930.036
guanosine containing compound metabolic processGO:190106840.036
guanosine containing compound catabolic processGO:190106920.036
gastrulationGO:00073692080.036
lymphocyte differentiationGO:003009890.036
ovulation cycleGO:004269820.035
sensory perception of chemical stimulusGO:000760630.035
regulation of synapse organizationGO:005080730.035
positive regulation of apoptotic signaling pathwayGO:200123510.035
locomotor rhythmGO:004547530.034
regulation of transmembrane transporter activityGO:002289820.034
regulation of membrane potentialGO:0042391230.034
pigmentationGO:0043473850.034
actin mediated cell contractionGO:007025210.034
gtp catabolic processGO:000618420.034
anterior posterior pattern specificationGO:00099521520.034
single organism nuclear importGO:190259330.034
positive regulation of cytokine productionGO:000181920.034
post embryonic organ developmentGO:004856940.034
smooth muscle contractionGO:000693920.034
protein targeting to nucleusGO:004474430.033
positive regulation of nucleobase containing compound metabolic processGO:0045935690.033
response to hexoseGO:000974630.033
cellular component biogenesisGO:00440851780.033
regulation of reproductive processGO:200024140.033
b cell differentiationGO:003018310.033
positive regulation of biosynthetic processGO:0009891680.033
stem cell fate commitmentGO:004886510.033
neuron projection morphogenesisGO:00488121610.033
positive regulation of transcription dna templatedGO:0045893570.032
determination of heart left right asymmetryGO:00613711170.032
cell migrationGO:00164772370.032
positive regulation of response to external stimulusGO:003210390.032
axon developmentGO:00615641660.032
synaptic growth at neuromuscular junctionGO:005112420.032
purine ribonucleotide biosynthetic processGO:0009152200.032
maintenance of locationGO:005123540.032
female gonad developmentGO:000858540.032
regulation of endocrine processGO:004406020.032
phagocytosisGO:000690930.031
blood vessel developmentGO:00015682460.031
extrinsic apoptotic signaling pathway in absence of ligandGO:009719210.031
nucleotide biosynthetic processGO:0009165210.031
multicellular organismal metabolic processGO:004423620.031
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domainsGO:000246040.031
regulation of extrinsic apoptotic signaling pathwayGO:200123630.031
nuclear transportGO:005116940.031
positive regulation of jnk cascadeGO:004633030.031
neuromast developmentGO:0048884460.031
nucleocytoplasmic transportGO:000691340.031
intracellular signal transductionGO:0035556850.031
cytokinesisGO:000091030.031
cellular localizationGO:0051641970.031
blood vessel morphogenesisGO:00485142160.031
camera type eye developmentGO:00430102220.031
regulation of carbohydrate metabolic processGO:000610940.031
cell migration involved in gastrulationGO:0042074790.031
regulation of blood pressureGO:000821710.031
response to biotic stimulusGO:0009607970.030
positive regulation of programmed cell deathGO:0043068290.030
single organism biosynthetic processGO:0044711710.030
establishment of localizationGO:00512342440.030
cellular protein modification processGO:00064641000.030
ribonucleotide biosynthetic processGO:0009260200.030
regulation of nucleotide catabolic processGO:003081120.029
cell cycleGO:0007049930.029
regulation of cellular component organizationGO:0051128860.029
positive regulation of cell communicationGO:0010647560.029
regulation of leukocyte mediated immunityGO:000270310.029
positive regulation of blood circulationGO:190352420.029
somitogenesisGO:0001756870.029
organonitrogen compound biosynthetic processGO:1901566470.029
negative regulation of apoptotic processGO:0043066550.029
signal transduction in absence of ligandGO:003803410.029
establishment of organelle localizationGO:0051656450.029
positive regulation of signal transductionGO:0009967560.029
negative regulation of kinase activityGO:003367340.028
energy reserve metabolic processGO:000611220.028
glial cell migrationGO:000834730.028
centrosome organizationGO:005129710.028
cell projection assemblyGO:0030031640.028
regulation of transcription from rna polymerase ii promoterGO:00063571140.028
cell morphogenesis involved in differentiationGO:00009041950.028
negative regulation of programmed cell deathGO:0043069580.028
negative regulation of protein phosphorylationGO:000193340.028
negative regulation of sequence specific dna binding transcription factor activityGO:004343320.028
regulation of cell proliferationGO:0042127370.028
single organism transportGO:00447652060.027
cellular amide metabolic processGO:004360340.027
negative regulation of cell deathGO:0060548600.027
regulation of blood vessel sizeGO:005088020.027
response to foodGO:003209410.027
regulation of multicellular organism growthGO:004001440.027
regulation of purine nucleotide catabolic processGO:003312120.027
organelle localizationGO:0051640490.027
ubiquitin dependent protein catabolic processGO:000651130.027
proteolysis involved in cellular protein catabolic processGO:005160330.027
positive regulation of immune effector processGO:000269930.027
regulation of protein metabolic processGO:0051246560.027
positive regulation of wound healingGO:009030310.026
cellular response to chemical stimulusGO:00708871570.026
positive regulation of purine nucleotide catabolic processGO:003312310.026
glucose importGO:004632320.026
cellular response to biotic stimulusGO:007121630.026
leukocyte differentiationGO:0002521250.026
cytosolic calcium ion transportGO:006040130.026
response to monosaccharideGO:003428430.026
negative regulation of map kinase activityGO:004340720.026
positive regulation of gtp catabolic processGO:003312610.026
positive regulation of protein kinase b signalingGO:005189710.025
mitotic cell cycleGO:0000278640.025
female sex differentiationGO:004666040.025
gland developmentGO:00487321430.025
somatic muscle developmentGO:000752540.025
cilium movementGO:0003341260.025
neural crest cell differentiationGO:0014033720.025
connective tissue developmentGO:0061448990.025
taxisGO:00423301090.024
single organism cell adhesionGO:0098602290.024
protein metabolic processGO:00195381830.024
modification dependent protein catabolic processGO:001994130.024
protein modification processGO:00362111000.024
regulation of protein catabolic processGO:004217610.024
fin developmentGO:0033333770.024
regulation of response to stressGO:0080134360.024
nuclear importGO:005117030.024
cellular protein catabolic processGO:004425740.024
embryonic organ morphogenesisGO:00485622740.024
cell cycle g1 s phase transitionGO:004484310.024
positive regulation of rna metabolic processGO:0051254590.024
protein localizationGO:0008104400.023
positive regulation of macromolecule biosynthetic processGO:0010557590.023
peptidyl serine phosphorylationGO:001810510.023
negative regulation of cellular biosynthetic processGO:0031327550.023
regulation of systemic arterial blood pressureGO:000307310.023
embryo development ending in birth or egg hatchingGO:00097922710.023
positive regulation of erk1 and erk2 cascadeGO:007037420.023
embryonic heart tube morphogenesisGO:00031431080.023
regulation of nucleoside metabolic processGO:000911820.023
development of primary female sexual characteristicsGO:004654540.023
regulation of epithelial cell proliferationGO:005067830.023
negative regulation of developmental processGO:0051093650.023
cellular response to hormone stimulusGO:0032870390.022
regulation of immune system processGO:0002682340.022
negative regulation of macromolecule metabolic processGO:0010605760.022
regulation of hormone secretionGO:004688320.022
regulation of immune effector processGO:000269750.022
regulation of cellular carbohydrate metabolic processGO:001067540.022
spermatid differentiationGO:004851520.022
regulation of response to nutrient levelsGO:003210710.022
embryonic pattern specificationGO:0009880440.022
cilium organizationGO:0044782710.022
positive regulation of rna biosynthetic processGO:1902680570.022
negative regulation of biosynthetic processGO:0009890550.022
g1 s transition of mitotic cell cycleGO:000008210.022
single organism behaviorGO:0044708240.022
response to glucoseGO:000974930.022
sexual reproductionGO:0019953360.022
small molecule catabolic processGO:004428230.022
establishment of protein localization to organelleGO:007259440.022
cation transportGO:0006812810.021
adherens junction organizationGO:003433240.021
cell proliferationGO:0008283800.021
establishment of localization in cellGO:0051649770.021
positive regulation of cell proliferationGO:0008284150.021
phosphorylationGO:0016310690.021
regulation of catalytic activityGO:0050790550.021
convergent extensionGO:00600261180.021
regulation of dendrite developmentGO:005077330.021
g protein coupled receptor signaling pathwayGO:0007186740.021
regulation of gtpase activityGO:004308720.021
vasculature developmentGO:00019442780.021
positive regulation of inflammatory responseGO:005072910.020
organelle organizationGO:00069962270.020
carbohydrate derivative metabolic processGO:1901135610.020
collagen metabolic processGO:003296320.020
protein importGO:001703830.020
inner ear developmentGO:00488391260.020
positive regulation of leukocyte mediated immunityGO:000270510.020
regulation of cytoplasmic transportGO:190364940.020
modification dependent macromolecule catabolic processGO:004363230.020
positive regulation of molecular functionGO:0044093330.020
regulation of nervous system developmentGO:0051960900.020
myeloid cell differentiationGO:0030099860.020
regulation of organ growthGO:004662030.019
specification of symmetryGO:00097992040.019
regulation of gtp catabolic processGO:003312420.019
regulation of tube sizeGO:003515020.019
adenylate cyclase modulating g protein coupled receptor signaling pathwayGO:000718850.019
negative regulation of cell differentiationGO:0045596460.019
organic acid catabolic processGO:001605430.019
hormone transportGO:000991420.019
eye morphogenesisGO:00485921440.019
cyclic nucleotide biosynthetic processGO:0009190180.019
leukocyte homeostasisGO:000177620.019
spermatid developmentGO:000728620.019
positive regulation of response to woundingGO:190303650.019
positive regulation of extrinsic apoptotic signaling pathwayGO:200123810.019
peptidyl serine modificationGO:001820920.019
positive regulation of cellular amino acid metabolic processGO:004576400.019
protein phosphorylationGO:0006468470.019
regulation of reactive oxygen species metabolic processGO:200037720.019
negative regulation of immune responseGO:005077720.019
sex determinationGO:000753010.019
long chain fatty acid transportGO:001590910.018
regulation of jak stat cascadeGO:004642530.018
startle responseGO:000196440.018
wnt signaling pathwayGO:0016055800.018
organic substance transportGO:0071702580.018
regulation of response to biotic stimulusGO:000283120.018
regulation of locomotionGO:0040012550.018
multicellular organismal signalingGO:0035637220.018
ribose phosphate biosynthetic processGO:0046390200.018
purine containing compound biosynthetic processGO:0072522200.018
determination of bilateral symmetryGO:00098552040.018
regulation of muscle contractionGO:000693730.018
regulation of response to external stimulusGO:0032101310.018
regulation of cell projection assemblyGO:006049140.018
response to external biotic stimulusGO:0043207970.018
posterior lateral line neuromast developmentGO:0048919200.018
positive regulation of lymphocyte mediated immunityGO:000270810.018
positive regulation of lipid metabolic processGO:004583410.018
macromolecule localizationGO:0033036540.018
regulation of phosphorus metabolic processGO:0051174430.018
lateral line system developmentGO:0048925760.017
double strand break repairGO:000630230.017
cranial nerve developmentGO:0021545420.017
pigment granule transportGO:0051904190.017
regulation of anatomical structure morphogenesisGO:00226031300.017
lymphocyte homeostasisGO:000226010.017
regulation of synapse assemblyGO:005196330.017
negative regulation of protein serine threonine kinase activityGO:007190120.017
regulation of cell shapeGO:000836010.017
ovulation cycle processGO:002260220.017
positive regulation of cell divisionGO:005178120.017
cellular response to radiationGO:007147840.017
protein import into nucleusGO:000660630.017
positive regulation of cell adhesionGO:004578510.017
regulation of dna replicationGO:000627530.017
negative regulation of macromolecule biosynthetic processGO:0010558480.017
negative regulation of dna metabolic processGO:005105340.017
regulation of response to extracellular stimulusGO:003210410.017
angiogenesisGO:00015251580.017
negative regulation of reproductive processGO:200024230.017
endoderm developmentGO:0007492490.017
dicarboxylic acid metabolic processGO:004364810.017
striated muscle cell differentiationGO:00511461290.017
skeletal system morphogenesisGO:00487051020.017
regulation of cyclase activityGO:0031279120.017
regulation of transportGO:0051049450.017
gastrulation with mouth forming secondGO:0001702440.017
activation of mapk activityGO:000018730.017
oxidation reduction processGO:0055114410.017
lipid catabolic processGO:001604240.017
regulation of mrna splicing via spliceosomeGO:004802430.017
regulation of neuron projection developmentGO:0010975400.017
regulation of ion transportGO:0043269220.017
axonogenesisGO:00074091520.016
transmission of nerve impulseGO:0019226190.016
regulation of cellular protein catabolic processGO:190336210.016
positive regulation of lyase activityGO:005134960.016
embryonic heart tube developmentGO:00350501330.016
circulatory system processGO:0003013870.016
positive regulation of apoptotic processGO:0043065290.016
positive regulation of cellular carbohydrate metabolic processGO:001067610.016
peptide metabolic processGO:000651810.016
wound healingGO:0042060900.016
epithelial tube morphogenesisGO:00605621480.016
negative regulation of mapk cascadeGO:004340940.016
positive regulation of transcription from rna polymerase ii promoterGO:0045944220.016
heart morphogenesisGO:00030071560.016
positive regulation of myeloid cell differentiationGO:004563920.016
regulation of protein complex assemblyGO:004325430.016
action potentialGO:0001508190.016
regulation of synaptic growth at neuromuscular junctionGO:000858210.016
intracellular mrna localizationGO:000829810.016
single organism organelle organizationGO:19025891990.016
carbohydrate biosynthetic processGO:001605110.016
cellular component assembly involved in morphogenesisGO:00109271070.015
cilium or flagellum dependent cell motilityGO:000153940.015
proteasome mediated ubiquitin dependent protein catabolic processGO:004316120.015

alk disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.089
disease of metabolismDOID:001466700.029
nervous system diseaseDOID:86300.024
disease of cellular proliferationDOID:1456600.019
organ system cancerDOID:005068600.018
cancerDOID:16200.018