Danio rerio

46 known processes

tsc2

tuberous sclerosis 2

(Aliases: wu:fc16b02,tuberin,fc16b02)

tsc2 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
cell motilityGO:00488702440.167
chordate embryonic developmentGO:00430092710.158
cellular component movementGO:00069283350.133
single organism transportGO:00447652060.127
organelle organizationGO:00069962270.126
sensory organ developmentGO:00074233930.126
meiotic nuclear divisionGO:000712640.121
cellular protein catabolic processGO:004425740.111
head developmentGO:00603223030.098
multicellular organism growthGO:003526440.094
establishment of localizationGO:00512342440.092
single organism localizationGO:19025782250.088
protein localization to nucleusGO:003450430.084
protein targeting to nucleusGO:004474430.084
larval developmentGO:000216420.082
agingGO:000756820.081
brain developmentGO:00074202930.077
organelle assemblyGO:00709251100.075
cell projection morphogenesisGO:00488582440.074
immune system developmentGO:00025201910.074
morphogenesis of an epitheliumGO:00020093330.073
single organism nuclear importGO:190259330.071
central nervous system developmentGO:00074173870.070
axon guidanceGO:0007411860.070
carboxylic acid catabolic processGO:004639530.069
digestive tract developmentGO:00485652650.069
regulation of stem cell proliferationGO:007209120.068
blood vessel morphogenesisGO:00485142160.066
regulation of cell matrix adhesionGO:000195210.066
lipid catabolic processGO:001604240.066
nitrogen compound metabolic processGO:00068073190.065
cell substrate adhesionGO:003158940.064
protein importGO:001703830.064
embryonic cranial skeleton morphogenesisGO:0048701900.063
regulation of multicellular organism growthGO:004001440.061
regulation of metabolic processGO:00192223590.061
vasculature developmentGO:00019442780.061
spindle assemblyGO:005122520.059
protein import into nucleusGO:000660630.057
cell part morphogenesisGO:00329902460.057
myeloid cell differentiationGO:0030099860.056
establishment of protein localization to organelleGO:007259440.055
determination of left right symmetryGO:00073681790.055
mitochondrion morphogenesisGO:007058420.055
meiotic cell cycle processGO:190304630.055
cilium morphogenesisGO:0060271850.054
proteolysis involved in cellular protein catabolic processGO:005160330.054
cellular ketone metabolic processGO:0042180110.053
eye developmentGO:00016542770.053
regulation of endothelial cell proliferationGO:000193610.052
generation of neuronsGO:00486993850.051
single organism metabolic processGO:00447102170.051
locomotor rhythmGO:004547530.051
growthGO:00400071740.051
oxoacid metabolic processGO:0043436310.050
cell matrix adhesionGO:000716040.050
cellular macromolecule metabolic processGO:00442603910.050
glial cell proliferationGO:001400940.050
determination of bilateral symmetryGO:00098552040.049
regulation of erk1 and erk2 cascadeGO:007037240.048
cellular biosynthetic processGO:00442492860.048
establishment of melanosome localizationGO:0032401190.048
embryonic organ morphogenesisGO:00485622740.047
negative regulation of ras protein signal transductionGO:004658010.046
guanosine containing compound metabolic processGO:190106840.046
nuclear importGO:005117030.046
meiotic chromosome segregationGO:004513230.046
organic acid catabolic processGO:001605430.044
cellular component biogenesisGO:00440851780.044
specification of symmetryGO:00097992040.044
single organism organelle organizationGO:19025891990.044
sensory organ morphogenesisGO:00905962000.044
negative regulation of protein transportGO:005122430.044
modification dependent protein catabolic processGO:001994130.044
positive regulation of camp biosynthetic processGO:003081920.044
regulation of nucleoside metabolic processGO:000911820.043
regulation of neural precursor cell proliferationGO:200017730.043
positive regulation of epithelial cell proliferationGO:005067910.043
stem cell proliferationGO:007208940.042
microtubule organizing center organizationGO:003102310.041
guanosine containing compound catabolic processGO:190106920.041
cytoskeleton organizationGO:0007010960.041
negative regulation of gliogenesisGO:001401410.040
locomotionGO:00400113130.040
fatty acid beta oxidationGO:000663510.040
negative regulation of kinase activityGO:003367340.040
localization of cellGO:00516742440.040
nucleobase containing compound biosynthetic processGO:00346542050.040
regulation of glial cell differentiationGO:004568540.040
neural tube developmentGO:0021915620.039
regulation of autophagyGO:001050630.039
regulation of macromolecule metabolic processGO:00602553170.039
regulation of cellular ketone metabolic processGO:001056570.039
ameboidal type cell migrationGO:00016671430.039
single organism cellular localizationGO:1902580460.038
modification dependent macromolecule catabolic processGO:004363230.038
positive regulation of catabolic processGO:000989640.038
positive regulation of cellular catabolic processGO:003133130.038
brain morphogenesisGO:0048854180.038
maintenance of locationGO:005123540.037
eye morphogenesisGO:00485921440.037
positive regulation of endothelial cell proliferationGO:000193810.037
fatty acid catabolic processGO:000906210.037
liver developmentGO:0001889960.037
blood vessel developmentGO:00015682460.037
skeletal system morphogenesisGO:00487051020.037
lipid storageGO:001991510.037
gtp metabolic processGO:004603940.037
transmission of nerve impulseGO:0019226190.036
regulation of cellular metabolic processGO:00313233200.036
negative regulation of cytoplasmic transportGO:190365020.036
microtubule based processGO:0007017600.036
response to chemicalGO:00422213200.036
regulation of nucleocytoplasmic transportGO:004682220.035
negative regulation of protein kinase activityGO:000646940.035
endosomal transportGO:001619720.035
centrosome organizationGO:005129710.035
cellular nitrogen compound metabolic processGO:00346412900.034
synaptic growth at neuromuscular junctionGO:005112420.034
skeletal system developmentGO:00015011810.034
melanosome transportGO:0032402190.034
transportGO:00068102200.034
regulation of protein import into nucleusGO:004230620.034
regenerationGO:0031099910.034
startle responseGO:000196440.033
cellular component assemblyGO:00226071700.033
apoptotic processGO:00069151160.033
regulation of oligodendrocyte differentiationGO:004871310.033
lipid oxidationGO:003444010.032
cellular component morphogenesisGO:00329893360.031
embryonic skeletal system morphogenesisGO:0048704930.031
cellular protein modification processGO:00064641000.031
cellular component disassemblyGO:002241110.031
negative regulation of small gtpase mediated signal transductionGO:005105810.031
small molecule metabolic processGO:0044281770.031
organic acid metabolic processGO:0006082310.031
negative regulation of protein phosphorylationGO:000193340.031
cellular lipid catabolic processGO:004424230.031
nucleocytoplasmic transportGO:000691340.031
regulation of multicellular organismal processGO:00512392770.031
erk1 and erk2 cascadeGO:007037140.031
regulation of gtp catabolic processGO:003312420.030
negative regulation of protein localization to nucleusGO:190018120.030
axon developmentGO:00615641660.030
autophagyGO:000691440.029
developmental growthGO:00485891660.029
cell morphogenesis involved in neuron differentiationGO:00486671630.029
neural crest cell developmentGO:0014032620.029
response to drugGO:004249330.029
amine metabolic processGO:000930820.029
protein metabolic processGO:00195381830.029
cellular response to hypoxiaGO:007145610.028
vesicle localizationGO:0051648270.028
nucleobase containing compound metabolic processGO:00061392740.028
regulation of nucleotide catabolic processGO:003081120.027
cellular response to extracellular stimulusGO:003166820.027
regulation of multicellular organismal developmentGO:20000262230.027
response to external stimulusGO:00096052640.027
microtubule based movementGO:0007018330.027
digestive tract morphogenesisGO:00485462310.027
cellular amine metabolic processGO:004410620.027
fatty acid oxidationGO:001939510.027
pigmentationGO:0043473850.027
nuclear transportGO:005116940.027
collagen fibril organizationGO:003019910.026
heart loopingGO:0001947940.026
spindle assembly involved in mitosisGO:009030710.026
regulation of intracellular protein transportGO:003315730.026
protein modification processGO:00362111000.026
heterocycle metabolic processGO:00464832900.026
cellular response to external stimulusGO:007149620.026
maintenance of gastrointestinal epitheliumGO:003027770.026
cilium movementGO:0003341260.026
embryonic organ developmentGO:00485683810.026
macromolecule modificationGO:00434121110.025
phosphatidylinositol 3 kinase signalingGO:001406520.025
proteasomal protein catabolic processGO:001049820.025
positive regulation of camp metabolic processGO:003081620.025
regulation of cellular amine metabolic processGO:003323800.025
carboxylic acid metabolic processGO:0019752220.025
neural crest cell migrationGO:0001755420.024
organic substance catabolic processGO:1901575280.024
regulation of protein modification by small protein conjugation or removalGO:190332030.024
cellular response to nutrient levelsGO:003166920.024
small molecule catabolic processGO:004428230.024
renal filtrationGO:0097205100.024
hemopoiesisGO:00300971830.024
cellular response to oxygen levelsGO:007145310.024
cellular response to starvationGO:000926710.024
cell morphogenesis involved in differentiationGO:00009041950.024
neuroblast proliferationGO:000740520.024
positive regulation of apoptotic signaling pathwayGO:200123510.023
regulation of neurotransmitter secretionGO:004692810.023
regulation of protein bindingGO:004339330.023
embryonic heart tube morphogenesisGO:00031431080.023
mitochondrion organizationGO:000700540.023
negative regulation of epithelial cell proliferationGO:005068010.023
regulation of bindingGO:005109830.023
regulation of cellular amino acid metabolic processGO:000652100.022
phosphate containing compound metabolic processGO:00067961080.022
astrocyte differentiationGO:004870810.022
positive regulation of neuron apoptotic processGO:004352510.022
angiogenesisGO:00015251580.022
muscle structure developmentGO:00610611960.022
deathGO:00162651210.022
gtp catabolic processGO:000618420.022
positive regulation of stem cell proliferationGO:200064810.022
cellular aromatic compound metabolic processGO:00067252950.022
digestive system developmentGO:00551232890.022
regulation of protein targetingGO:190353320.022
cell projection organizationGO:00300302840.022
muscle cell developmentGO:00550011150.021
negative regulation of nucleocytoplasmic transportGO:004682320.021
proteasome mediated ubiquitin dependent protein catabolic processGO:004316120.021
gene expressionGO:00104672520.021
ubiquitin dependent protein catabolic processGO:000651130.021
extrinsic apoptotic signaling pathwayGO:009719130.021
nucleoside monophosphate catabolic processGO:000912540.021
cell agingGO:000756920.021
positive regulation of gtp catabolic processGO:003312610.021
pigment granule localizationGO:0051875250.021
mitotic dna damage checkpointGO:004477340.020
regulation of circadian rhythmGO:004275240.020
regulation of cellular protein catabolic processGO:190336210.020
cell morphogenesisGO:00009022890.020
regulation of nitrogen compound metabolic processGO:00511712510.020
protein localizationGO:0008104400.020
heart developmentGO:00075073130.020
transmembrane receptor protein tyrosine kinase signaling pathwayGO:0007169420.020
maturation of ssu rrnaGO:003049010.020
embryonic heart tube developmentGO:00350501330.020
neuron projection developmentGO:00311751800.020
autonomic nervous system developmentGO:0048483190.020
embryonic skeletal system developmentGO:0048706970.020
immune system processGO:00023762410.019
cell deathGO:00082191210.019
negative regulation of intracellular protein transportGO:009031730.019
lymphocyte proliferationGO:004665110.019
lipid metabolic processGO:0006629520.019
cell cycle g1 s phase transitionGO:004484310.019
embryonic viscerocranium morphogenesisGO:0048703520.019
organic cyclic compound metabolic processGO:19013603010.019
cellular lipid metabolic processGO:0044255360.019
cell surface receptor signaling pathwayGO:00071663250.019
regulation of rac protein signal transductionGO:003502010.019
cognitionGO:005089010.019
cellular protein metabolic processGO:00442671290.019
convergent extensionGO:00600261180.019
negative regulation of intracellular transportGO:003238730.019
establishment of vesicle localizationGO:0051650240.019
somite developmentGO:0061053960.019
mitotic dna integrity checkpointGO:004477440.019
cellular pigmentationGO:0033059300.019
regulation of production of molecular mediator of immune responseGO:000270010.019
positive regulation of gtpase activityGO:004354710.018
regulation of lipid catabolic processGO:005099420.018
monocarboxylic acid catabolic processGO:007232930.018
regulation of cytoplasmic transportGO:190364940.018
regulation of epithelial cell proliferationGO:005067830.018
nucleic acid templated transcriptionGO:00976591810.018
regulation of microtubule cytoskeleton organizationGO:007050730.018
compound eye developmentGO:004874920.018
microtubule cytoskeleton organization involved in mitosisGO:190285010.018
osteoclast differentiationGO:003031610.018
ribosomal small subunit biogenesisGO:004227420.018
neuromast developmentGO:0048884460.018
cell migrationGO:00164772370.018
atp catabolic processGO:000620040.018
convergent extension involved in gastrulationGO:0060027710.018
dna metabolic processGO:0006259270.018
meiosis iGO:000712710.018
organic substance biosynthetic processGO:19015762890.018
regulation of proteolysis involved in cellular protein catabolic processGO:190305010.018
determination of heart left right asymmetryGO:00613711170.018
stem cell differentiationGO:00488631170.018
regulation of ras gtpase activityGO:003231820.017
regulation of protein transportGO:005122330.017
homeostasis of number of cellsGO:0048872620.017
neurotransmitter secretionGO:000726920.017
positive regulation of cellular amino acid metabolic processGO:004576400.017
regulation of synapse organizationGO:005080730.017
positive regulation of nucleoside metabolic processGO:004597910.017
cellular response to decreased oxygen levelsGO:003629410.017
regulation of synaptic growth at neuromuscular junctionGO:000858210.017
response to topologically incorrect proteinGO:003596620.017
regulation of ion transmembrane transporter activityGO:003241220.017
tube morphogenesisGO:00352393490.017
camera type eye morphogenesisGO:00485931080.017
pigment granule transportGO:0051904190.017
chemosensory behaviorGO:000763510.017
regulation of protein complex assemblyGO:004325430.017
positive regulation of protein complex assemblyGO:003133420.017
macromolecular complex subunit organizationGO:0043933740.017
positive regulation of purine nucleotide catabolic processGO:003312310.016
organic cyclic compound biosynthetic processGO:19013622230.016
positive regulation of neuron deathGO:190121610.016
cellular hormone metabolic processGO:0034754190.016
system processGO:00030081850.016
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domainsGO:000246040.016
negative regulation of sequence specific dna binding transcription factor activityGO:004343320.016
regulation of reproductive processGO:200024140.016
nephron tubule morphogenesisGO:007207810.016
regulation of synapse assemblyGO:005196330.016
homeostatic processGO:00425921420.016
rna localizationGO:000640340.016
adult behaviorGO:003053420.016
protein complex disassemblyGO:004324110.016
neuron neuron synaptic transmissionGO:000727010.016
regulation of purine nucleotide catabolic processGO:003312120.016
regulation of nucleobase containing compound metabolic processGO:00192192500.016
positive regulation of biological processGO:00485182530.016
regulation of cyclase activityGO:0031279120.015
positive regulation of secretionGO:005104710.015
wnt signaling pathwayGO:0016055800.015
tube closureGO:006060610.015
cellular catabolic processGO:0044248270.015
neuron developmentGO:00486662620.015
regulation of cell activationGO:005086510.015
negative regulation of synapse assemblyGO:005196420.015
pancreas developmentGO:0031016840.015
extrinsic apoptotic signaling pathway via death domain receptorsGO:000862510.015
positive regulation of cellular component biogenesisGO:004408930.015
response to uvGO:000941130.015
g2 dna damage checkpointGO:003157230.015
biosynthetic processGO:00090582940.015
small gtpase mediated signal transductionGO:000726480.015
cellular amino acid metabolic processGO:000652070.015
regulation of synaptic plasticityGO:004816710.015
negative regulation of map kinase activityGO:004340720.015
positive regulation of extrinsic apoptotic signaling pathwayGO:200123810.015
cellular response to chemical stimulusGO:00708871570.015
regulation of cellular macromolecule biosynthetic processGO:20001122220.015
synaptic vesicle localizationGO:009747910.015
neuron differentiationGO:00301823530.015
stem cell maintenanceGO:001982740.015
positive regulation of cytoskeleton organizationGO:005149530.015
striated muscle cell developmentGO:00550021080.015
nuclear exportGO:005116810.015
embryo development ending in birth or egg hatchingGO:00097922710.015
macromolecular complex disassemblyGO:003298410.015
regulation of meiotic cell cycleGO:005144510.015
neuron projection guidanceGO:0097485860.015
primary neural tube formationGO:001402010.015
developmental programmed cell deathGO:001062340.015
negative regulation of leukocyte differentiationGO:190210610.015
nucleic acid metabolic processGO:00903042440.015
ion transportGO:00068111140.015
regulation of cellular response to growth factor stimulusGO:0090287350.014
smooth muscle tissue developmentGO:004874510.014
heart morphogenesisGO:00030071560.014
protein localization to plasma membraneGO:007265910.014
transcription dna templatedGO:00063511810.014
aromatic compound biosynthetic processGO:00194382170.014
regulation of protein ubiquitinationGO:003139630.014
ribonucleoside monophosphate catabolic processGO:000915840.014
g1 s transition of mitotic cell cycleGO:000008210.014
positive regulation of cell activationGO:005086710.014
regulation of membrane potentialGO:0042391230.014
regulation of cytokine productionGO:000181730.014
regulation of vasculature developmentGO:1901342330.014
sympathetic nervous system developmentGO:004848530.014
regulation of signal transductionGO:00099662250.014
production of molecular mediator of immune responseGO:000244020.014
regulation of establishment of protein localizationGO:007020140.014
axonogenesisGO:00074091520.014
golgi organizationGO:000703010.014
protein complex biogenesisGO:0070271300.014
lateral line system developmentGO:0048925760.014
glycerolipid biosynthetic processGO:004501710.014
positive regulation of erk1 and erk2 cascadeGO:007037420.014
macroautophagyGO:001623610.014
neural tube patterningGO:0021532330.014
enzyme linked receptor protein signaling pathwayGO:00071671060.014
extracellular matrix organizationGO:0030198270.014
neuron apoptotic processGO:0051402200.013
antimicrobial humoral responseGO:001973020.013
mesenchyme developmentGO:00604851270.013
protein polymerizationGO:005125840.013
microtubule depolymerizationGO:000701910.013
renal system processGO:0003014140.013
leukocyte homeostasisGO:000177620.013
positive regulation of stress activated mapk cascadeGO:003287430.013
leukocyte differentiationGO:0002521250.013
establishment of pigment granule localizationGO:0051905220.013
extracellular structure organizationGO:0043062270.013
regulation of neurogenesisGO:0050767870.013
negative regulation of autophagyGO:001050710.013
microtubule polymerization or depolymerizationGO:003110930.013
transmembrane transportGO:00550851200.013
oligodendrocyte differentiationGO:0048709230.013
cellular protein complex disassemblyGO:004362410.013
regulation of blood vessel sizeGO:005088020.013
appendage morphogenesisGO:0035107560.013
tissue remodelingGO:004877140.013
establishment of synaptic vesicle localizationGO:009748010.013
response to organic substanceGO:00100331530.013
renal tubule morphogenesisGO:006133310.013
phosphatidylinositol mediated signalingGO:004801520.013
mesenchymal cell developmentGO:0014031780.013
regulation of gene expressionGO:00104682650.013
fin developmentGO:0033333770.012
cellular localizationGO:0051641970.012
cellular component assembly involved in morphogenesisGO:00109271070.012
regulation of neuronal synaptic plasticityGO:004816810.012
regulation of protein localization to nucleusGO:190018020.012
cellular macromolecule biosynthetic processGO:00346452240.012
neuron projection morphogenesisGO:00488121610.012
regulation of nervous system developmentGO:0051960900.012
regulation of peptidyl tyrosine phosphorylationGO:005073010.012
muscle cell differentiationGO:00426921390.012
nucleobase containing small molecule metabolic processGO:0055086320.012
positive regulation of map kinase activityGO:004340630.012
regulation of tissue remodelingGO:003410320.012
wound healingGO:0042060900.012
synaptic vesicle transportGO:004848910.012
sprouting angiogenesisGO:0002040530.012
internal protein amino acid acetylationGO:000647520.012
regulation of organ growthGO:004662030.012
hepaticobiliary system developmentGO:0061008980.012
cellular amide metabolic processGO:004360340.012
regulation of apoptotic processGO:0042981980.012
axonal defasciculationGO:000741420.012
protein depolymerizationGO:005126110.012
leukocyte proliferationGO:007066110.012
odontogenesis of dentin containing toothGO:004247510.012
peptidyl threonine phosphorylationGO:001810710.012
peptidyl serine modificationGO:001820920.012
regulation of dna replicationGO:000627530.012
oxidative phosphorylationGO:000611910.012
cell killingGO:000190620.012
regulation of transmembrane transporter activityGO:002289820.012
positive regulation of myeloid cell differentiationGO:004563920.012
cytokinesisGO:000091030.012
regulation of signalingGO:00230512350.012
purine nucleoside monophosphate catabolic processGO:000912840.012
sleepGO:003043110.011
regulation of cell developmentGO:00602841000.011
organic substance transportGO:0071702580.011
cell substrate adherens junction assemblyGO:000704510.011
cell cycle arrestGO:000705010.011
melanosome localizationGO:0032400210.011
regulation of transporter activityGO:003240920.011
peptidyl serine phosphorylationGO:001810510.011
camera type eye developmentGO:00430102220.011
neuronal action potentialGO:0019228180.011
fin morphogenesisGO:0033334530.011
positive regulation of histone modificationGO:003105810.011
positive regulation of translationGO:004572710.011
negative regulation of cellular catabolic processGO:003133030.011
cellular nitrogen compound biosynthetic processGO:00442712180.011
positive regulation of cellular metabolic processGO:0031325940.011
regulation of gtpase activityGO:004308720.011
centrosome cycleGO:000709810.011
b cell activationGO:004211320.011
retina layer formationGO:0010842240.011
sensory system developmentGO:0048880760.011
regulation of bone remodelingGO:004685020.011
negative regulation of chromosome organizationGO:200125110.011
positive regulation of lyase activityGO:005134960.011
regulation of histone methylationGO:003106030.011
mesenchymal cell differentiationGO:0048762870.011
purine ribonucleoside monophosphate catabolic processGO:000916940.011
actin filament polymerizationGO:003004120.011
negative regulation of neural precursor cell proliferationGO:200017810.011
rna metabolic processGO:00160702190.011
dorsal ventral pattern formationGO:00099531250.011
gland developmentGO:00487321430.011
organonitrogen compound metabolic processGO:1901564740.011
chromosome organizationGO:0051276310.011
organophosphate metabolic processGO:0019637370.011
regulation of cell projection assemblyGO:006049140.011
myofibril assemblyGO:0030239480.011
regulation of neurotransmitter transportGO:005158810.011
regulation of rho protein signal transductionGO:003502320.011
actin cytoskeleton organizationGO:0030036630.011
embryonic hemopoiesisGO:0035162530.011
exocytosisGO:000688710.011
thermosensory behaviorGO:004004010.011
regulation of reactive oxygen species metabolic processGO:200037720.011
positive regulation of cellular amine metabolic processGO:003324000.011
cellular biogenic amine metabolic processGO:000657620.011

tsc2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.063
cardiovascular system diseaseDOID:128700.063
disease of cellular proliferationDOID:1456600.031
nervous system diseaseDOID:86300.020
musculoskeletal system diseaseDOID:1700.017
muscular diseaseDOID:008000000.016
muscle tissue diseaseDOID:6600.016
myopathyDOID:42300.016
cancerDOID:16200.013
organ system cancerDOID:005068600.012
disease of metabolismDOID:001466700.011
heart diseaseDOID:11400.011
inherited metabolic disorderDOID:65500.011
immune system diseaseDOID:291400.011