IMP: Integrative Multi-species Prediction

Danio rerio

6 known processes

cirh1a

cirrhosis, autosomal recessive 1A (cirhin)

(Aliases: zgc:77199,wu:fi37c02,wu:fi09g10)

Entrez: 406571
ZFIN: ZDB-GENE-040426-2466
Ensembl: ENSDARG00000017675
UniProtKB: Q6P125

Process Predictions
Disease Predictions

cirh1a biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
cellular aromatic compound metabolic process	GO:0006725	295	0.307	Human Yeast
embryo development ending in birth or egg hatching	GO:0009792	271	0.280
aging	GO:0007568	2	0.207
larval development	GO:0002164	2	0.189
gene expression	GO:0010467	252	0.183	Human Yeast
regulation of metabolic process	GO:0019222	359	0.167	Human Yeast
organic cyclic compound metabolic process	GO:1901360	301	0.146	Human Yeast
nucleic acid metabolic process	GO:0090304	244	0.138	Human Yeast
nitrogen compound metabolic process	GO:0006807	319	0.134	Human Yeast
guanosine containing compound metabolic process	GO:1901068	4	0.086
single organism metabolic process	GO:0044710	217	0.086
cellular nitrogen compound metabolic process	GO:0034641	290	0.083	Human Yeast
maturation of ssu rrna	GO:0030490	1	0.076	Human Yeast
centrosome organization	GO:0051297	1	0.069
single organism biosynthetic process	GO:0044711	71	0.068
rna processing	GO:0006396	25	0.066	Human Yeast
small molecule metabolic process	GO:0044281	77	0.062
negative regulation of biological process	GO:0048519	304	0.060
heterocycle metabolic process	GO:0046483	290	0.057	Human Yeast
cellular component movement	GO:0006928	335	0.056
organic substance biosynthetic process	GO:1901576	289	0.055	Human Yeast
maintenance of location	GO:0051235	4	0.055
ribosomal small subunit biogenesis	GO:0042274	2	0.054	Human Yeast
cellular component biogenesis	GO:0044085	178	0.052	Human Yeast
organic cyclic compound biosynthetic process	GO:1901362	223	0.052	Human Yeast
ribosome assembly	GO:0042255	1	0.052
guanosine containing compound catabolic process	GO:1901069	2	0.050
rna metabolic process	GO:0016070	219	0.049	Human Yeast
locomotion	GO:0040011	313	0.048
regulation of nucleobase containing compound metabolic process	GO:0019219	250	0.044	Human Yeast
regulation of cellular metabolic process	GO:0031323	320	0.044	Human Yeast
multicellular organism growth	GO:0035264	4	0.042
cellular macromolecule metabolic process	GO:0044260	391	0.041	Human Yeast
gtp catabolic process	GO:0006184	2	0.040
cell migration	GO:0016477	237	0.040
hematopoietic or lymphoid organ development	GO:0048534	191	0.039
regulation of macromolecule biosynthetic process	GO:0010556	225	0.037	Human Yeast
gtp metabolic process	GO:0046039	4	0.037
regulation of biological quality	GO:0065008	263	0.037
localization of cell	GO:0051674	244	0.036
negative regulation of macromolecule metabolic process	GO:0010605	76	0.036
b cell activation	GO:0042113	2	0.035
central nervous system development	GO:0007417	387	0.035
regulation of gene expression	GO:0010468	265	0.035	Human Yeast
cellular biosynthetic process	GO:0044249	286	0.035	Human Yeast
lipid storage	GO:0019915	1	0.034
chordate embryonic development	GO:0043009	271	0.034
generation of neurons	GO:0048699	385	0.034
regulation of multicellular organism growth	GO:0040014	4	0.033
nucleocytoplasmic transport	GO:0006913	4	0.033
regulation of nitrogen compound metabolic process	GO:0051171	251	0.032	Human Yeast
regulation of macromolecule metabolic process	GO:0060255	317	0.031	Human Yeast
immune system process	GO:0002376	241	0.031
nuclear transport	GO:0051169	4	0.029
leukocyte proliferation	GO:0070661	1	0.027
regulation of multicellular organismal process	GO:0051239	277	0.027
pancreas development	GO:0031016	84	0.027
response to external biotic stimulus	GO:0043207	97	0.027
macromolecule biosynthetic process	GO:0009059	227	0.027	Human Yeast
regulation of nucleic acid templated transcription	GO:1903506	213	0.027	Human Yeast
regulation of biosynthetic process	GO:0009889	250	0.027	Human Yeast
phagocytosis	GO:0006909	3	0.027
maturation of ssu rrna from tricistronic rrna transcript ssu rrna 5 8s rrna lsu rrna	GO:0000462	1	0.026	Yeast
regulation of cellular macromolecule biosynthetic process	GO:2000112	222	0.024	Human Yeast
organelle assembly	GO:0070925	110	0.023
hemopoiesis	GO:0030097	183	0.023
cell morphogenesis	GO:0000902	289	0.022
cellular component disassembly	GO:0022411	1	0.022
response to other organism	GO:0051707	97	0.021
organonitrogen compound metabolic process	GO:1901564	74	0.021
regulation of protein ubiquitination	GO:0031396	3	0.021
protein acetylation	GO:0006473	2	0.021
nucleobase containing compound metabolic process	GO:0006139	274	0.021	Human Yeast
ribonucleoprotein complex biogenesis	GO:0022613	13	0.021	Human Yeast
stem cell proliferation	GO:0072089	4	0.021
cell projection morphogenesis	GO:0048858	244	0.021
sensory organ development	GO:0007423	393	0.019
positive regulation of cell cycle	GO:0045787	3	0.019
alpha amino acid metabolic process	GO:1901605	3	0.019
single organism localization	GO:1902578	225	0.019
single organism reproductive process	GO:0044702	40	0.019
response to external stimulus	GO:0009605	264	0.018
posttranscriptional gene silencing by rna	GO:0035194	3	0.018
cellular component morphogenesis	GO:0032989	336	0.018
aromatic compound biosynthetic process	GO:0019438	217	0.018	Human Yeast
cell part morphogenesis	GO:0032990	246	0.018
regulation of gene expression epigenetic	GO:0040029	11	0.017
regulation of rna metabolic process	GO:0051252	224	0.017	Human Yeast
cellular nitrogen compound biosynthetic process	GO:0044271	218	0.017	Human Yeast
microtubule polymerization or depolymerization	GO:0031109	3	0.017
negative regulation of metabolic process	GO:0009892	86	0.017
cell motility	GO:0048870	244	0.017
multicellular organism reproduction	GO:0032504	35	0.017
neuron differentiation	GO:0030182	353	0.016
determination of heart left right asymmetry	GO:0061371	117	0.016
posttranscriptional gene silencing	GO:0016441	3	0.016
multi organism process	GO:0051704	134	0.016
cell proliferation	GO:0008283	80	0.016
response to nutrient	GO:0007584	3	0.016
ribosome biogenesis	GO:0042254	9	0.016	Human Yeast
muscle organ development	GO:0007517	101	0.016
negative regulation of gene expression	GO:0010629	65	0.016
microtubule organizing center organization	GO:0031023	1	0.015
macromolecule modification	GO:0043412	111	0.015
phosphate containing compound metabolic process	GO:0006796	108	0.015
nucleobase containing compound biosynthetic process	GO:0034654	205	0.014	Human Yeast
nuclear export	GO:0051168	1	0.014
cellular aldehyde metabolic process	GO:0006081	4	0.014
regulation of cell differentiation	GO:0045595	142	0.014
nucleic acid templated transcription	GO:0097659	181	0.014	Human Yeast
regulation of binding	GO:0051098	3	0.013
gene silencing by rna	GO:0031047	4	0.013
exocrine pancreas development	GO:0031017	28	0.013
multicellular organismal reproductive process	GO:0048609	35	0.013
developmental growth	GO:0048589	166	0.013
gamete generation	GO:0007276	33	0.013
positive regulation of biological process	GO:0048518	253	0.013	Yeast
exocrine system development	GO:0035272	28	0.013
post embryonic morphogenesis	GO:0009886	4	0.013
peptidyl lysine acetylation	GO:0018394	2	0.012
b cell differentiation	GO:0030183	1	0.012
dna biosynthetic process	GO:0071897	3	0.012
sexual reproduction	GO:0019953	36	0.012
vesicle mediated transport	GO:0016192	22	0.012
ncrna metabolic process	GO:0034660	12	0.012	Human Yeast
neuron projection morphogenesis	GO:0048812	161	0.012
regulation of carbohydrate metabolic process	GO:0006109	4	0.012
cellular macromolecular complex assembly	GO:0034622	24	0.012
specification of symmetry	GO:0009799	204	0.012
reproductive process	GO:0022414	40	0.012
gene silencing	GO:0016458	4	0.012
organic acid metabolic process	GO:0006082	31	0.012
phosphorus metabolic process	GO:0006793	109	0.012
regulation of cell communication	GO:0010646	232	0.012
cellular response to external stimulus	GO:0071496	2	0.012
biosynthetic process	GO:0009058	294	0.012	Human Yeast
response to chemical	GO:0042221	320	0.012
protein modification process	GO:0036211	100	0.012
nucleoside metabolic process	GO:0009116	11	0.012
positive regulation of muscle tissue development	GO:1901863	1	0.012
camera type eye development	GO:0043010	222	0.011
stem cell differentiation	GO:0048863	117	0.011
cellular response to starvation	GO:0009267	1	0.011
regulation of primary metabolic process	GO:0080090	311	0.011	Human Yeast
organic substance catabolic process	GO:1901575	28	0.011
regulation of protein modification by small protein conjugation or removal	GO:1903320	3	0.011
cell morphogenesis involved in neuron differentiation	GO:0048667	163	0.011
organophosphate metabolic process	GO:0019637	37	0.011
regulation of dna replication	GO:0006275	3	0.011
cellular macromolecule biosynthetic process	GO:0034645	224	0.011	Human Yeast
cellular response to nutrient levels	GO:0031669	2	0.011
determination of left right symmetry	GO:0007368	179	0.011
regulation of transcription dna templated	GO:0006355	213	0.011	Human Yeast
determination of bilateral symmetry	GO:0009855	204	0.011
regulation of anatomical structure morphogenesis	GO:0022603	130	0.011
gland development	GO:0048732	143	0.011
protein acylation	GO:0043543	3	0.010
striated muscle cell development	GO:0055002	108	0.010
ribonucleotide metabolic process	GO:0009259	27	0.010
ncrna processing	GO:0034470	8	0.010	Human Yeast
transport	GO:0006810	220	0.010

cirh1a disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.049
nervous system disease	DOID:863	0.022
sensory system disease	DOID:0050155	0.022
disease of metabolism	DOID:0014667	0.018
inherited metabolic disorder	DOID:655	0.015

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