Danio rerio

0 known processes

mknk2a

MAP kinase-interacting serine/threonine kinase 2a

(Aliases: zgc:55587,fi34c11,wu:fi41e12,wu:fi34c11)

mknk2a biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
regulation of biosynthetic processGO:00098892500.122
nitrogen compound metabolic processGO:00068073190.090
positive regulation of catabolic processGO:000989640.088
regulation of nitrogen compound metabolic processGO:00511712510.088
positive regulation of cellular catabolic processGO:003133130.079
positive regulation of nitrogen compound metabolic processGO:0051173690.079
cellular nitrogen compound metabolic processGO:00346412900.078
protein localization to nucleusGO:003450430.078
macromolecule biosynthetic processGO:00090592270.072
nucleobase containing compound metabolic processGO:00061392740.071
regulation of metabolic processGO:00192223590.070
regulation of nucleobase containing compound metabolic processGO:00192192500.063
regulation of cellular biosynthetic processGO:00313262450.062
organic cyclic compound metabolic processGO:19013603010.061
regulation of primary metabolic processGO:00800903110.056
gene expressionGO:00104672520.055
regulation of nucleoside metabolic processGO:000911820.054
negative regulation of cellular processGO:00485232830.053
Fly
phosphorus metabolic processGO:00067931090.052
Human Mouse Fly
autophagyGO:000691440.052
organelle organizationGO:00069962270.051
cellular nitrogen compound biosynthetic processGO:00442712180.051
regulation of nucleotide catabolic processGO:003081120.050
establishment of protein localization to organelleGO:007259440.050
regulation of transcription dna templatedGO:00063552130.049
single organism localizationGO:19025782250.047
rna metabolic processGO:00160702190.047
meiotic nuclear divisionGO:000712640.047
regulation of cellular macromolecule biosynthetic processGO:20001122220.047
cellular component assemblyGO:00226071700.047
chordate embryonic developmentGO:00430092710.047
organic substance biosynthetic processGO:19015762890.046
guanosine containing compound catabolic processGO:190106920.045
single organism metabolic processGO:00447102170.043
guanosine containing compound metabolic processGO:190106840.042
biosynthetic processGO:00090582940.040
single organism biosynthetic processGO:0044711710.040
protein import into nucleusGO:000660630.040
single organism nuclear importGO:190259330.039
single organism transportGO:00447652060.039
regulation of protein complex assemblyGO:004325430.039
nucleic acid templated transcriptionGO:00976591810.039
rna biosynthetic processGO:00327741810.038
positive regulation of purine nucleotide catabolic processGO:003312310.037
heterocycle biosynthetic processGO:00181302150.037
regulation of protein localization to nucleusGO:190018020.036
regulation of cellular metabolic processGO:00313233200.036
larval developmentGO:000216420.035
positive regulation of nucleoside metabolic processGO:004597910.035
amine metabolic processGO:000930820.035
positive regulation of gtp catabolic processGO:003312610.035
nucleocytoplasmic transportGO:000691340.034
negative regulation of biological processGO:00485193040.034
Fly
gtp catabolic processGO:000618420.034
regulation of signal transductionGO:00099662250.034
Fly
gtp metabolic processGO:004603940.034
cell surface receptor signaling pathwayGO:00071663250.033
Mouse
nuclear transportGO:005116940.033
regulation of nucleic acid templated transcriptionGO:19035062130.033
cellular macromolecule biosynthetic processGO:00346452240.033
organic cyclic compound biosynthetic processGO:19013622230.032
regulation of protein catabolic processGO:004217610.032
agingGO:000756820.032
regulation of rna metabolic processGO:00512522240.032
embryo development ending in birth or egg hatchingGO:00097922710.032
nuclear importGO:005117030.031
response to stressGO:00069502630.031
macromolecular complex subunit organizationGO:0043933740.031
regionalizationGO:00030022740.030
regulation of purine nucleotide catabolic processGO:003312120.030
positive regulation of cell cycleGO:004578730.030
embryonic organ developmentGO:00485683810.030
positive regulation of gtpase activityGO:004354710.030
negative regulation of cell communicationGO:0010648960.030
Fly
organonitrogen compound metabolic processGO:1901564740.030
maintenance of locationGO:005123540.029
regulation of stem cell differentiationGO:200073640.029
nucleic acid metabolic processGO:00903042440.029
protein importGO:001703830.029
positive regulation of cellular processGO:00485222010.029
positive regulation of biological processGO:00485182530.029
regulation of gtpase activityGO:004308720.029
regulation of developmental processGO:00507932470.029
transcription dna templatedGO:00063511810.028
phosphate containing compound metabolic processGO:00067961080.028
Human Mouse Fly
phagocytosisGO:000690930.028
regulation of multicellular organismal processGO:00512392770.028
nucleobase containing compound biosynthetic processGO:00346542050.028
regulation of gtp catabolic processGO:003312420.028
cellular amine metabolic processGO:004410620.027
tube morphogenesisGO:00352393490.027
skeletal system developmentGO:00015011810.027
cellular carbohydrate metabolic processGO:004426240.027
positive regulation of metabolic processGO:00098931080.027
regulation of multicellular organism growthGO:004001440.027
negative regulation of protein phosphorylationGO:000193340.026
regulation of cell communicationGO:00106462320.026
Fly
cellular aromatic compound metabolic processGO:00067252950.026
carbohydrate biosynthetic processGO:001605110.026
neuron differentiationGO:00301823530.026
regulation of multicellular organismal developmentGO:20000262230.026
cell part morphogenesisGO:00329902460.026
stem cell divisionGO:001714510.026
regulation of protein transportGO:005122330.026
regulation of intracellular protein transportGO:003315730.025
positive regulation of nucleotide catabolic processGO:003081310.025
regulation of gene expressionGO:00104682650.025
carboxylic acid metabolic processGO:0019752220.025
transportGO:00068102200.025
cellular component biogenesisGO:00440851780.024
localization of cellGO:00516742440.024
regulation of cytoplasmic transportGO:190364940.024
central nervous system developmentGO:00074173870.024
aromatic compound biosynthetic processGO:00194382170.024
locomotionGO:00400113130.024
long chain fatty acid transportGO:001590910.024
lipid storageGO:001991510.024
protein targeting to nucleusGO:004474430.024
small molecule metabolic processGO:0044281770.024
centrosome organizationGO:005129710.023
regulation of response to stimulusGO:00485832690.023
Fly
endosomal transportGO:001619720.023
negative regulation of protein complex assemblyGO:003133310.023
eye developmentGO:00016542770.023
regulation of macromolecule metabolic processGO:00602553170.023
apoptotic process involved in developmentGO:190274220.023
negative regulation of signalingGO:0023057960.023
Fly
cellular component disassemblyGO:002241110.023
single organism organelle organizationGO:19025891990.023
regulation of skeletal muscle fiber developmentGO:004874220.023
digestive system developmentGO:00551232890.023
regulation of autophagyGO:001050630.022
cellular ketone metabolic processGO:0042180110.022
negative regulation of signal transductionGO:0009968940.022
Fly
regulation of lipid catabolic processGO:005099420.021
lipid metabolic processGO:0006629520.021
multicellular organism growthGO:003526440.021
regulation of cellular ketone metabolic processGO:001056570.021
embryonic organ morphogenesisGO:00485622740.021
regulation of rna biosynthetic processGO:20011412130.021
modification dependent protein catabolic processGO:001994130.021
transcription from rna polymerase ii promoterGO:0006366800.021
positive regulation of transportGO:005105020.020
regulation of biological qualityGO:00650082630.020
response to nutrientGO:000758430.020
meiotic cell cycle processGO:190304630.020
meiosis iGO:000712710.020
protein polymerizationGO:005125840.020
regulation of cell differentiationGO:00455951420.020
negative regulation of kinase activityGO:003367340.020
ubiquitin dependent protein catabolic processGO:000651130.020
negative regulation of catabolic processGO:000989530.020
positive regulation of protein complex assemblyGO:003133420.020
alcohol biosynthetic processGO:004616520.020
signal transductionGO:00071654550.020
Human Mouse Fly
cellular macromolecule metabolic processGO:00442603910.019
Human Mouse Fly
generation of neuronsGO:00486993850.019
positive regulation of cellular component biogenesisGO:004408930.019
heart developmentGO:00075073130.019
cellular protein metabolic processGO:00442671290.019
Human Mouse Fly
negative regulation of dna metabolic processGO:005105340.019
intracellular signal transductionGO:0035556850.019
Human Mouse Fly
negative regulation of cytokine productionGO:000181810.019
regulation of cellular amine metabolic processGO:003323800.019
cell motilityGO:00488702440.019
cellular component movementGO:00069283350.019
proteasome mediated ubiquitin dependent protein catabolic processGO:004316120.019
protein heterooligomerizationGO:005129110.019
peptide transportGO:001583310.018
regulation of reproductive processGO:200024140.018
regulation of protein targetingGO:190353320.018
heterocycle metabolic processGO:00464832900.018
negative regulation of cytoplasmic transportGO:190365020.018
g1 s transition of mitotic cell cycleGO:000008210.018
hormone secretionGO:004687920.018
cell projection organizationGO:00300302840.018
regulation of hormone secretionGO:004688320.018
muscle cell developmentGO:00550011150.018
regulation of signalingGO:00230512350.018
Fly
negative regulation of response to stimulusGO:00485851040.018
Fly
microtubule organizing center organizationGO:003102310.018
regulation of filopodium assemblyGO:005148920.018
response to corticosteroidGO:003196010.017
cell cycleGO:0007049930.017
stem cell maintenanceGO:001982740.017
regulation of cytokine productionGO:000181730.017
cartilage condensationGO:000150230.017
negative regulation of protein transportGO:005122430.017
organophosphate metabolic processGO:0019637370.017
positive regulation of map kinase activityGO:004340630.017
oxoacid metabolic processGO:0043436310.017
lipid catabolic processGO:001604240.017
response to endogenous stimulusGO:0009719830.017
regulation of biomineral tissue developmentGO:007016720.017
muscle structure developmentGO:00610611960.017
regulation of dendrite developmentGO:005077330.017
regulation of establishment of protein localizationGO:007020140.017
positive regulation of nucleobase containing compound metabolic processGO:0045935690.016
regulation of cellular amino acid metabolic processGO:000652100.016
regulation of i kappab kinase nf kappab signalingGO:004312240.016
regulation of synaptic growth at neuromuscular junctionGO:000858210.016
stem cell proliferationGO:007208940.016
response to drugGO:004249330.016
negative regulation of intracellular transportGO:003238730.016
organic anion transportGO:0015711150.016
central nervous system neuron differentiationGO:0021953740.016
superoxide metabolic processGO:000680120.016
negative regulation of protein kinase activityGO:000646940.016
modification dependent macromolecule catabolic processGO:004363230.016
gastrulationGO:00073692080.016
neuron developmentGO:00486662620.016
lymphocyte proliferationGO:004665110.016
embryonic heart tube developmentGO:00350501330.016
muscle cell differentiationGO:00426921390.016
proteasomal protein catabolic processGO:001049820.015
cytokinesisGO:000091030.015
rhombomere 5 developmentGO:002157140.015
synaptic growth at neuromuscular junctionGO:005112420.015
response to glucocorticoidGO:005138410.015
lateral inhibitionGO:004633110.015
cell migrationGO:00164772370.015
cell morphogenesisGO:00009022890.015
protein complex subunit organizationGO:0071822460.015
peptidyl lysine acetylationGO:001839420.015
regulation of epithelial to mesenchymal transitionGO:001071730.015
single organism membrane fusionGO:004480120.015
symbiosis encompassing mutualism through parasitismGO:004440340.015
positive regulation of macromolecule metabolic processGO:0010604930.015
golgi vesicle transportGO:004819330.015
fatty acid transportGO:001590810.015
regulation of macromolecule biosynthetic processGO:00105562250.015
digestive tract developmentGO:00485652650.015
cell cycle g1 s phase transitionGO:004484310.015
i kappab kinase nf kappab signalingGO:000724940.015
cellular response to organic substanceGO:00713101050.015
cellular response to chemical stimulusGO:00708871570.015
Human
centrosome cycleGO:000709810.015
ameboidal type cell migrationGO:00016671430.015
response to hexoseGO:000974630.015
positive regulation of canonical wnt signaling pathwayGO:009026340.015
regulation of transcription from rna polymerase ii promoterGO:00063571140.015
cellular amino acid metabolic processGO:000652070.015
lipid homeostasisGO:005508830.015
positive regulation of cell adhesionGO:004578510.015
negative regulation of muscle cell differentiationGO:005114810.014
regulation of nucleocytoplasmic transportGO:004682220.014
chemosensory behaviorGO:000763510.014
protein complex disassemblyGO:004324110.014
hormone transportGO:000991420.014
cell projection morphogenesisGO:00488582440.014
regulation of cell activationGO:005086510.014
regulation of chondrocyte differentiationGO:003233010.014
primary neural tube formationGO:001402010.014
cell matrix adhesionGO:000716040.014
regulation of molecular functionGO:0065009700.014
organelle fusionGO:004828430.014
regulation of dna replicationGO:000627530.014
small molecule catabolic processGO:004428230.014
regulation of rho protein signal transductionGO:003502320.014
regulation of epithelial cell proliferationGO:005067830.014
cellular protein catabolic processGO:004425740.014
response to hormoneGO:0009725480.014
regulation of catalytic activityGO:0050790550.014
regulation of peptidyl tyrosine phosphorylationGO:005073010.014
response to xenobiotic stimulusGO:0009410450.014
response to vitaminGO:003327330.014
regulation of glucose transportGO:001082710.014
cellular response to extracellular stimulusGO:003166820.014
cellular lipid catabolic processGO:004424230.014
gland developmentGO:00487321430.014
positive regulation of cytoskeleton organizationGO:005149530.014
blood vessel developmentGO:00015682460.013
deathGO:00162651210.013
Mouse
membrane invaginationGO:001032410.013
cellular catabolic processGO:0044248270.013
protein acylationGO:004354330.013
tube closureGO:006060610.013
germ line stem cell maintenanceGO:003071820.013
regulation of glucose importGO:004632410.013
embryonic heart tube morphogenesisGO:00031431080.013
homeostatic processGO:00425921420.013
regulation of carbohydrate metabolic processGO:000610940.013
response to chemicalGO:00422213200.013
Human
dorsal ventral pattern formationGO:00099531250.013
positive regulation of cellular carbohydrate metabolic processGO:001067610.013
vasculature developmentGO:00019442780.013
brain developmentGO:00074202930.013
female sex differentiationGO:004666040.013
activation of mapk activityGO:000018730.013
cellular lipid metabolic processGO:0044255360.013
organic acid metabolic processGO:0006082310.013
negative regulation of bmp signaling pathwayGO:0030514130.013
negative regulation of protein serine threonine kinase activityGO:007190120.013
er to golgi vesicle mediated transportGO:000688810.013
membrane lipid biosynthetic processGO:004646720.013
regulation of cell matrix adhesionGO:000195210.013
dna templated transcription initiationGO:000635210.013
oocyte maturationGO:000155640.013
microtubule based processGO:0007017600.013
Fly
response to fluid shear stressGO:003440520.013
extrinsic apoptotic signaling pathwayGO:009719130.013
Mouse
regulation of production of molecular mediator of immune responseGO:000270010.013
regulation of protein polymerizationGO:003227120.012
negative regulation of metabolic processGO:0009892860.012
regulation of phosphate metabolic processGO:0019220430.012
macromolecular complex disassemblyGO:003298410.012
mononuclear cell proliferationGO:003294310.012
negative regulation of extrinsic apoptotic signaling pathwayGO:200123720.012
cellular biosynthetic processGO:00442492860.012
protein acetylationGO:000647320.012
cellular response to external stimulusGO:007149620.012
compound eye developmentGO:004874920.012
cellular response to endogenous stimulusGO:0071495680.012
sensory organ developmentGO:00074233930.012
protein complex assemblyGO:0006461300.012
response to monosaccharideGO:003428430.012
circadian sleep wake cycleGO:004274520.012
catechol containing compound metabolic processGO:000971220.012
determination of heart left right asymmetryGO:00613711170.012
regulation of organelle assemblyGO:190211540.012
b cell mediated immunityGO:001972430.012
positive regulation of i kappab kinase nf kappab signalingGO:004312330.012
response to alkaloidGO:004327920.012
proteolysis involved in cellular protein catabolic processGO:005160330.012
convergent extensionGO:00600261180.012
carbohydrate homeostasisGO:003350010.012
regulation of synapse assemblyGO:005196330.012
protein polyubiquitinationGO:000020940.012
cellular response to starvationGO:000926710.012
organic substance transportGO:0071702580.012
internal protein amino acid acetylationGO:000647520.012
regulation of cell developmentGO:00602841000.012
internal peptidyl lysine acetylationGO:001839320.012
zymogen activationGO:003163830.012
negative regulation of macromolecule metabolic processGO:0010605760.012
inositol lipid mediated signalingGO:004801720.012
cell substrate adhesionGO:003158940.012
epithelial tube morphogenesisGO:00605621480.011
positive regulation of muscle organ developmentGO:004863610.011
negative regulation of nitrogen compound metabolic processGO:0051172590.011
cell cycle arrestGO:000705010.011
neuroblast proliferationGO:000740520.011
camera type eye developmentGO:00430102220.011
forebrain cell migrationGO:002188510.011
catabolic processGO:0009056320.011
regulation of protein import into nucleusGO:004230620.011
response to carbohydrateGO:000974330.011
negative regulation of mapk cascadeGO:004340940.011
ceramide biosynthetic processGO:004651310.011
regulation of proteolysis involved in cellular protein catabolic processGO:190305010.011
positive regulation of stress activated protein kinase signaling cascadeGO:007030430.011
b cell activationGO:004211320.011
cell proliferationGO:0008283800.011
negative regulation of protein localization to nucleusGO:190018120.011
cognitionGO:005089010.011
liver developmentGO:0001889960.011
cell morphogenesis involved in neuron differentiationGO:00486671630.011
cellular response to nutrient levelsGO:003166920.011
angiogenesisGO:00015251580.011
cellular protein modification processGO:00064641000.011
Human Mouse Fly
mitotic cell cycleGO:0000278640.011
regulation of cell shapeGO:000836010.011
negative regulation of synapse assemblyGO:005196420.011
cellular response to decreased oxygen levelsGO:003629410.011
response to glucoseGO:000974930.011
positive regulation of protein polymerizationGO:003227320.011
actin polymerization or depolymerizationGO:000815420.011
regulation of cellular carbohydrate metabolic processGO:001067540.011
regulation of reactive oxygen species metabolic processGO:200037720.011
positive regulation of purine nucleotide metabolic processGO:190054490.011
negative regulation of sequence specific dna binding transcription factor activityGO:004343320.011
astrocyte differentiationGO:004870810.011
peptidyl serine modificationGO:001820920.011
male meiosisGO:000714020.011
protein dephosphorylationGO:000647030.011
regulation of ras gtpase activityGO:003231820.010
cell deathGO:00082191210.010
Mouse
regulation of programmed cell deathGO:00430671010.010
negative regulation of nucleocytoplasmic transportGO:004682320.010
bmp signaling pathwayGO:0030509520.010
response to amino acidGO:004320020.010
skeletal system morphogenesisGO:00487051020.010
heart morphogenesisGO:00030071560.010
intracellular transportGO:0046907320.010
regulation of circadian sleep wake cycleGO:004274910.010
positive regulation of carbohydrate metabolic processGO:004591310.010
cellular localizationGO:0051641970.010
protein homooligomerizationGO:005126030.010
female gonad developmentGO:000858540.010
axon developmentGO:00615641660.010
cell cell recognitionGO:000998810.010
ribonucleotide metabolic processGO:0009259270.010
regulation of cell projection assemblyGO:006049140.010
adult behaviorGO:003053420.010
development of primary female sexual characteristicsGO:004654540.010
negative regulation of defense responseGO:003134820.010
membrane fusionGO:006102520.010
enzyme linked receptor protein signaling pathwayGO:00071671060.010
germ line stem cell divisionGO:004207810.010
long chain fatty acid metabolic processGO:000167610.010

mknk2a disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.043
disease of metabolismDOID:001466700.022
inherited metabolic disorderDOID:65500.022
musculoskeletal system diseaseDOID:1700.020
cardiovascular system diseaseDOID:128700.013
nervous system diseaseDOID:86300.012
muscle tissue diseaseDOID:6600.010
muscular diseaseDOID:008000000.010
myopathyDOID:42300.010