IMP: Integrative Multi-species Prediction

Danio rerio

18 known processes

atp1a3b

ATPase, Na+/K+ transporting, alpha 3b polypeptide

(Aliases: MGC109873,fj35g11,cb706,atp[a]3A,wu:fj35g11)

ZFIN: ZDB-GENE-001212-8
Ensembl: ENSDARG00000036815
Entrez: 64611
UniProtKB: Q4KMK4

Process Predictions
Disease Predictions

atp1a3b biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
ion transport	GO:0006811	114	0.652	Zebrafish Rat Worm Fly
transmembrane transport	GO:0055085	120	0.395	Zebrafish Worm Fly
sensory organ development	GO:0007423	393	0.387	Zebrafish
purine nucleoside monophosphate catabolic process	GO:0009128	4	0.379	Zebrafish Worm Fly
cell migration involved in heart development	GO:0060973	22	0.366	Zebrafish
cellular aromatic compound metabolic process	GO:0006725	295	0.354	Zebrafish Worm Fly
brain development	GO:0007420	293	0.303
determination of heart left right asymmetry	GO:0061371	117	0.287	Zebrafish
ribonucleoside monophosphate catabolic process	GO:0009158	4	0.272	Zebrafish Worm Fly
inner ear development	GO:0048839	126	0.269	Zebrafish
aging	GO:0007568	2	0.229	Fly
carbohydrate derivative metabolic process	GO:1901135	61	0.224	Zebrafish Worm Fly
atp catabolic process	GO:0006200	4	0.218	Zebrafish Worm Fly
system process	GO:0003008	185	0.211	Zebrafish Mouse Worm Fly
embryonic heart tube development	GO:0035050	133	0.208	Zebrafish
embryonic organ development	GO:0048568	381	0.203	Zebrafish
synaptic growth at neuromuscular junction	GO:0051124	2	0.200	Fly
neuromuscular process	GO:0050905	7	0.196	Fly
heart morphogenesis	GO:0003007	156	0.196	Zebrafish
determination of bilateral symmetry	GO:0009855	204	0.193	Zebrafish
response to external stimulus	GO:0009605	264	0.187	Zebrafish Fly
cation transport	GO:0006812	81	0.186	Zebrafish Rat Worm Fly
nucleoside monophosphate catabolic process	GO:0009125	4	0.186	Zebrafish Worm Fly
organic cyclic compound metabolic process	GO:1901360	301	0.186	Zebrafish Worm Fly
embryonic heart tube morphogenesis	GO:0003143	108	0.186	Zebrafish
peptidyl serine phosphorylation	GO:0018105	1	0.184
nitrogen compound metabolic process	GO:0006807	319	0.180	Zebrafish Worm Fly
response to carbohydrate	GO:0009743	3	0.176
tube morphogenesis	GO:0035239	349	0.172	Zebrafish
nucleobase containing compound metabolic process	GO:0006139	274	0.168	Zebrafish Worm Fly
heart looping	GO:0001947	94	0.164	Zebrafish
establishment of localization	GO:0051234	244	0.160	Zebrafish Rat Worm Fly
determination of left right symmetry	GO:0007368	179	0.158	Zebrafish
protein complex assembly	GO:0006461	30	0.157
morphogenesis of an epithelium	GO:0002009	333	0.153	Zebrafish
response to chemical	GO:0042221	320	0.145	Mouse
otic vesicle development	GO:0071599	42	0.144	Zebrafish
regulation of macromolecule metabolic process	GO:0060255	317	0.144
generation of neurons	GO:0048699	385	0.141
signal transduction	GO:0007165	455	0.140	Mouse
ear development	GO:0043583	127	0.136	Zebrafish
cellular nitrogen compound metabolic process	GO:0034641	290	0.135	Zebrafish Worm Fly
regulation of multicellular organismal development	GO:2000026	223	0.133
positive regulation of cellular component biogenesis	GO:0044089	3	0.131
cellular component assembly	GO:0022607	170	0.127	Fly
cellular component movement	GO:0006928	335	0.119	Zebrafish
regulation of metabolic process	GO:0019222	359	0.118
digestive tract development	GO:0048565	265	0.118
localization of cell	GO:0051674	244	0.114	Zebrafish
multicellular organism growth	GO:0035264	4	0.114
specification of symmetry	GO:0009799	204	0.114	Zebrafish
embryonic limb morphogenesis	GO:0030326	2	0.113
cellular biosynthetic process	GO:0044249	286	0.113
response to stress	GO:0006950	263	0.112
muscle cell development	GO:0055001	115	0.105
purine ribonucleoside monophosphate catabolic process	GO:0009169	4	0.104	Zebrafish Worm Fly
ectodermal placode morphogenesis	GO:0071697	32	0.103
regulation of biological quality	GO:0065008	263	0.102	Zebrafish Worm Fly
response to drug	GO:0042493	3	0.100	Mouse
regulation of cell shape	GO:0008360	1	0.100	Fly
muscle structure development	GO:0061061	196	0.094	Zebrafish
organonitrogen compound metabolic process	GO:1901564	74	0.094	Zebrafish Worm Fly
central nervous system development	GO:0007417	387	0.093
regulation of cellular macromolecule biosynthetic process	GO:2000112	222	0.093
melanin metabolic process	GO:0006582	2	0.092
sensory organ morphogenesis	GO:0090596	200	0.091	Zebrafish
macromolecular complex assembly	GO:0065003	35	0.091
regulation of localization	GO:0032879	104	0.089
larval development	GO:0002164	2	0.089	Worm
maintenance of location	GO:0051235	4	0.088
cation homeostasis	GO:0055080	33	0.088	Zebrafish
single organism transport	GO:0044765	206	0.088	Zebrafish Rat Worm Fly
startle response	GO:0001964	4	0.088
neurological system process	GO:0050877	62	0.085	Mouse Fly
cellular nitrogen compound biosynthetic process	GO:0044271	218	0.084
embryonic organ morphogenesis	GO:0048562	274	0.083	Zebrafish
regulation of macromolecule biosynthetic process	GO:0010556	225	0.083
aromatic compound biosynthetic process	GO:0019438	217	0.082
somite development	GO:0061053	96	0.082
lateral line development	GO:0048882	66	0.080
locomotory behavior	GO:0007626	34	0.079
small molecule metabolic process	GO:0044281	77	0.079	Zebrafish Worm Fly
cellular protein complex assembly	GO:0043623	19	0.077
phosphorus metabolic process	GO:0006793	109	0.076	Zebrafish Worm Fly
digestive tract morphogenesis	GO:0048546	231	0.076
ion homeostasis	GO:0050801	41	0.075	Zebrafish
protein complex biogenesis	GO:0070271	30	0.075
regulation of protein complex assembly	GO:0043254	3	0.074
ear morphogenesis	GO:0042471	64	0.072	Zebrafish
single organism localization	GO:1902578	225	0.070	Zebrafish Rat Worm Fly
striated muscle cell differentiation	GO:0051146	129	0.069
tissue homeostasis	GO:0001894	25	0.069	Fly
response to oxygen containing compound	GO:1901700	55	0.069
reflex	GO:0060004	2	0.068
otic vesicle morphogenesis	GO:0071600	34	0.068	Zebrafish
regulation of cellular component organization	GO:0051128	86	0.067	Fly
multi organism process	GO:0051704	134	0.066
metal ion transport	GO:0030001	58	0.066	Zebrafish Rat Worm Fly
response to monosaccharide	GO:0034284	3	0.065
regulation of anatomical structure morphogenesis	GO:0022603	130	0.065	Fly
specification of organ axis polarity	GO:0010084	2	0.065	Zebrafish
response to organic substance	GO:0010033	153	0.065
heterocycle metabolic process	GO:0046483	290	0.064	Zebrafish Worm Fly
neuron projection development	GO:0031175	180	0.064
neuromast development	GO:0048884	46	0.063
guanosine containing compound metabolic process	GO:1901068	4	0.062
purine ribonucleotide metabolic process	GO:0009150	27	0.062	Zebrafish Worm Fly
inner ear morphogenesis	GO:0042472	63	0.061	Zebrafish
regulation of cellular biosynthetic process	GO:0031326	245	0.061
organelle fusion	GO:0048284	3	0.061
membrane hyperpolarization	GO:0060081	1	0.060
nucleic acid metabolic process	GO:0090304	244	0.060
organic cyclic compound biosynthetic process	GO:1901362	223	0.059
cellular component biogenesis	GO:0044085	178	0.058	Fly
cellular macromolecule biosynthetic process	GO:0034645	224	0.058
positive regulation of catabolic process	GO:0009896	4	0.058
muscle tissue development	GO:0060537	110	0.058	Zebrafish
regulation of rna metabolic process	GO:0051252	224	0.057
cellular macromolecule metabolic process	GO:0044260	391	0.057
eye development	GO:0001654	277	0.056
oxoacid metabolic process	GO:0043436	31	0.055
neuron differentiation	GO:0030182	353	0.055
divalent metal ion transport	GO:0070838	20	0.054
biosynthetic process	GO:0009058	294	0.052
head development	GO:0060322	303	0.052
extracellular structure organization	GO:0043062	27	0.052	Zebrafish
cell cycle process	GO:0022402	53	0.051
locomotion	GO:0040011	313	0.051	Zebrafish
digestive system development	GO:0055123	289	0.051
sensory perception of mechanical stimulus	GO:0050954	16	0.051	Fly
regulation of ph	GO:0006885	3	0.050
muscle contraction	GO:0006936	18	0.050	Worm
transcription dna templated	GO:0006351	181	0.050
organic acid metabolic process	GO:0006082	31	0.050
macromolecule biosynthetic process	GO:0009059	227	0.049
sensory system development	GO:0048880	76	0.049
secondary metabolic process	GO:0019748	3	0.049
inorganic cation transmembrane transport	GO:0098662	50	0.048	Zebrafish Worm Fly
zymogen activation	GO:0031638	3	0.048
regulation of nucleobase containing compound metabolic process	GO:0019219	250	0.046
heart development	GO:0007507	313	0.046	Zebrafish
ion transmembrane transport	GO:0034220	91	0.046	Zebrafish Worm Fly
positive regulation of cellular catabolic process	GO:0031331	3	0.046
regulation of developmental process	GO:0050793	247	0.046	Fly
carboxylic acid metabolic process	GO:0019752	22	0.045
nephron tubule morphogenesis	GO:0072078	1	0.045
neuron development	GO:0048666	262	0.044
heterocycle biosynthetic process	GO:0018130	215	0.043
nucleobase containing compound biosynthetic process	GO:0034654	205	0.043
ribonucleoside metabolic process	GO:0009119	11	0.043	Zebrafish Worm Fly
cytokinesis	GO:0000910	3	0.043
calcium ion transport	GO:0006816	18	0.042
nucleic acid templated transcription	GO:0097659	181	0.041
regulation of transmembrane transporter activity	GO:0022898	2	0.041
rna metabolic process	GO:0016070	219	0.041
regulation of catalytic activity	GO:0050790	55	0.040
transport	GO:0006810	220	0.040	Zebrafish Rat Worm Fly
regulation of multicellular organismal process	GO:0051239	277	0.040	Worm
regulation of muscle contraction	GO:0006937	3	0.040	Worm
actin filament based process	GO:0030029	64	0.040
gene expression	GO:0010467	252	0.039
immune system process	GO:0002376	241	0.039
gland development	GO:0048732	143	0.039
purine ribonucleoside monophosphate metabolic process	GO:0009167	5	0.039	Zebrafish Worm Fly
otolith development	GO:0048840	32	0.039	Zebrafish
positive regulation of macromolecule metabolic process	GO:0010604	93	0.038
monovalent inorganic cation transport	GO:0015672	42	0.038	Zebrafish Rat Worm Fly
striated muscle cell development	GO:0055002	108	0.038
positive regulation of biological process	GO:0048518	253	0.038
response to alkaloid	GO:0043279	2	0.038
calcium ion homeostasis	GO:0055074	19	0.038	Zebrafish
apical junction assembly	GO:0043297	1	0.037	Fly
regulation of metal ion transport	GO:0010959	4	0.037
regulation of rna biosynthetic process	GO:2001141	213	0.037
rostrocaudal neural tube patterning	GO:0021903	29	0.036	Zebrafish
neurotransmitter transport	GO:0006836	2	0.036
negative regulation of response to stimulus	GO:0048585	104	0.036
axon development	GO:0061564	166	0.035
organic substance biosynthetic process	GO:1901576	289	0.034
cell surface receptor signaling pathway	GO:0007166	325	0.034	Mouse
myosin filament organization	GO:0031033	6	0.034
lateral line system development	GO:0048925	76	0.034
nucleobase containing small molecule metabolic process	GO:0055086	32	0.034	Zebrafish Worm Fly
hindbrain development	GO:0030902	91	0.034
adult behavior	GO:0030534	2	0.034	Mouse Fly
negative regulation of heart contraction	GO:0045822	2	0.033
striated muscle contraction	GO:0006941	12	0.033
striated muscle tissue development	GO:0014706	110	0.033	Zebrafish
regulation of synapse assembly	GO:0051963	3	0.033
cell projection organization	GO:0030030	284	0.033
smooth muscle contraction	GO:0006939	2	0.033
positive regulation of transport	GO:0051050	2	0.033
cell morphogenesis	GO:0000902	289	0.032	Fly
glycosyl compound metabolic process	GO:1901657	11	0.032	Zebrafish Worm Fly
ribose phosphate metabolic process	GO:0019693	27	0.032	Zebrafish Worm Fly
organelle organization	GO:0006996	227	0.032
regulation of multicellular organism growth	GO:0040014	4	0.032
regulation of protein polymerization	GO:0032271	2	0.032
heart contraction	GO:0060047	71	0.032	Zebrafish
establishment or maintenance of apical basal cell polarity	GO:0035088	12	0.032
sensory perception	GO:0007600	39	0.032	Fly
regulation of primary metabolic process	GO:0080090	311	0.031
cell projection morphogenesis	GO:0048858	244	0.031
regulation of nitrogen compound metabolic process	GO:0051171	251	0.031
regulation of biosynthetic process	GO:0009889	250	0.031
cellular response to external stimulus	GO:0071496	2	0.031
embryonic skeletal system development	GO:0048706	97	0.030
chordate embryonic development	GO:0043009	271	0.030	Zebrafish
cellular component disassembly	GO:0022411	1	0.030
response to hexose	GO:0009746	3	0.030
developmental growth	GO:0048589	166	0.029	Fly
single organism organelle organization	GO:1902589	199	0.029
cellular component morphogenesis	GO:0032989	336	0.029	Fly
growth	GO:0040007	174	0.029	Worm Fly
organic cyclic compound catabolic process	GO:1901361	15	0.029	Zebrafish Worm Fly
cation transmembrane transport	GO:0098655	65	0.029	Zebrafish Worm Fly
cortical actin cytoskeleton organization	GO:0030866	1	0.029
single organism biosynthetic process	GO:0044711	71	0.029
hormone transport	GO:0009914	2	0.028
regulation of synapse organization	GO:0050807	3	0.028
single organism membrane fusion	GO:0044801	2	0.028
cell motility	GO:0048870	244	0.028	Zebrafish
epithelial cell differentiation	GO:0030855	116	0.028
cellular localization	GO:0051641	97	0.028
protein complex subunit organization	GO:0071822	46	0.027
cellular response to radiation	GO:0071478	4	0.027
organelle localization	GO:0051640	49	0.027
regulation of synaptic growth at neuromuscular junction	GO:0008582	1	0.026
amine metabolic process	GO:0009308	2	0.026
negative regulation of signaling	GO:0023057	96	0.026
positive regulation of nucleotide catabolic process	GO:0030813	1	0.026
heart process	GO:0003015	71	0.026	Zebrafish
cellular component assembly involved in morphogenesis	GO:0010927	107	0.026
positive regulation of metabolic process	GO:0009893	108	0.026
establishment or maintenance of bipolar cell polarity	GO:0061245	12	0.026
regulation of dna replication	GO:0006275	3	0.025
membrane repolarization	GO:0086009	2	0.025
hormone biosynthetic process	GO:0042446	3	0.025
cellular ion homeostasis	GO:0006873	17	0.025	Zebrafish
response to lipid	GO:0033993	60	0.025
positive regulation of cell cycle	GO:0045787	3	0.024
determination of dorsal ventral asymmetry	GO:0048262	34	0.024
hair cell differentiation	GO:0035315	32	0.024
ameboidal type cell migration	GO:0001667	143	0.024
rna biosynthetic process	GO:0032774	181	0.024
circulatory system process	GO:0003013	87	0.024	Zebrafish
cell part morphogenesis	GO:0032990	246	0.023
cell proliferation	GO:0008283	80	0.023
single organism metabolic process	GO:0044710	217	0.023	Zebrafish Worm Fly
synaptic transmission	GO:0007268	35	0.023	Fly
phagocytosis	GO:0006909	3	0.023
response to radiation	GO:0009314	51	0.023	Mouse
negative regulation of cellular process	GO:0048523	283	0.023
embryo development ending in birth or egg hatching	GO:0009792	271	0.023	Zebrafish Worm Fly
regulation of transcription dna templated	GO:0006355	213	0.023
skin development	GO:0043588	54	0.022
response to glucose	GO:0009749	3	0.022
divalent inorganic cation transport	GO:0072511	21	0.022
regulation of protein transport	GO:0051223	3	0.022
ribonucleotide metabolic process	GO:0009259	27	0.022	Zebrafish Worm Fly
developmental programmed cell death	GO:0010623	4	0.022
regulation of ion transmembrane transporter activity	GO:0032412	2	0.022
semicircular canal development	GO:0060872	24	0.022	Zebrafish
multicellular organismal homeostasis	GO:0048871	29	0.022	Fly
axonogenesis	GO:0007409	152	0.022
purine containing compound metabolic process	GO:0072521	29	0.022	Zebrafish Worm Fly
sodium ion transport	GO:0006814	24	0.021	Zebrafish Rat Worm Fly
epidermal cell differentiation	GO:0009913	36	0.021
sensory perception of sound	GO:0007605	9	0.021	Fly
negative regulation of biological process	GO:0048519	304	0.021
cell morphogenesis involved in neuron differentiation	GO:0048667	163	0.021
cell cell signaling	GO:0007267	52	0.021	Fly
hormone secretion	GO:0046879	2	0.021
macromolecular complex disassembly	GO:0032984	1	0.021
specification of axis polarity	GO:0065001	4	0.021	Zebrafish
gastrulation	GO:0007369	208	0.020
response to endogenous stimulus	GO:0009719	83	0.020
positive regulation of cellular amino acid metabolic process	GO:0045764	0	0.020
macromolecular complex subunit organization	GO:0043933	74	0.020
synaptic target recognition	GO:0008039	1	0.020
cellular amino acid metabolic process	GO:0006520	7	0.020
cytoskeleton organization	GO:0007010	96	0.020
cell cell recognition	GO:0009988	1	0.019
microtubule based process	GO:0007017	60	0.019
negative regulation of blood circulation	GO:1903523	2	0.019
neuromuscular synaptic transmission	GO:0007274	2	0.019
actin cytoskeleton organization	GO:0030036	63	0.019
cellular response to chemical stimulus	GO:0070887	157	0.019
positive regulation of cellular process	GO:0048522	201	0.019
mitotic cell cycle	GO:0000278	64	0.019
semicircular canal morphogenesis	GO:0048752	18	0.019	Zebrafish
sodium ion transmembrane transport	GO:0035725	21	0.019	Zebrafish Worm Fly
regulation of establishment of protein localization	GO:0070201	4	0.018
muscle cell differentiation	GO:0042692	139	0.018
response to amino acid	GO:0043200	2	0.018
response to wounding	GO:0009611	116	0.018
response to organic cyclic compound	GO:0014070	51	0.018
posterior lateral line neuromast development	GO:0048919	20	0.018
cell migration	GO:0016477	237	0.018	Zebrafish
regulation of cardiac muscle contraction	GO:0055117	2	0.018
multicellular organismal signaling	GO:0035637	22	0.018
actomyosin structure organization	GO:0031032	53	0.018
rna modification	GO:0009451	2	0.018
nephron epithelium morphogenesis	GO:0072088	1	0.017
positive regulation of protein complex assembly	GO:0031334	2	0.017
positive regulation of catalytic activity	GO:0043085	25	0.017
regulation of cell motility	GO:2000145	46	0.017
response to abiotic stimulus	GO:0009628	122	0.017	Mouse Fly
protein complex disassembly	GO:0043241	1	0.017
mechanosensory lateral line system development	GO:0048881	49	0.017
neuron projection morphogenesis	GO:0048812	161	0.017
establishment of localization in cell	GO:0051649	77	0.017
stem cell proliferation	GO:0072089	4	0.017
divalent inorganic cation homeostasis	GO:0072507	22	0.017	Zebrafish
cellular response to stress	GO:0033554	62	0.017
negative regulation of protein phosphorylation	GO:0001933	4	0.017
membrane fusion	GO:0061025	2	0.017
response to steroid hormone	GO:0048545	35	0.016
guanosine containing compound catabolic process	GO:1901069	2	0.016
regulation of cellular metabolic process	GO:0031323	320	0.016
mitotic cell cycle process	GO:1903047	48	0.016
positive regulation of striated muscle tissue development	GO:0045844	1	0.016
cell projection assembly	GO:0030031	64	0.016
epidermis development	GO:0008544	48	0.016
regulation of transporter activity	GO:0032409	2	0.016
negative regulation of protein complex assembly	GO:0031333	1	0.016
meiotic nuclear division	GO:0007126	4	0.016
nucleobase containing compound catabolic process	GO:0034655	15	0.016	Zebrafish Worm Fly
gtp catabolic process	GO:0006184	2	0.016
somitogenesis	GO:0001756	87	0.016
defense response	GO:0006952	47	0.016
segmentation	GO:0035282	97	0.016
regulation of cell morphogenesis	GO:0022604	42	0.016	Fly
regeneration	GO:0031099	91	0.016
regulation of cell development	GO:0060284	100	0.015
macromolecule modification	GO:0043412	111	0.015
response to axon injury	GO:0048678	14	0.015
transmission of nerve impulse	GO:0019226	19	0.015
nephron morphogenesis	GO:0072028	2	0.015
positive regulation of cell communication	GO:0010647	56	0.015
phosphate containing compound metabolic process	GO:0006796	108	0.015	Zebrafish Worm Fly
exocytosis	GO:0006887	1	0.015
regulation of kinase activity	GO:0043549	15	0.015
stem cell maintenance	GO:0019827	4	0.015
leukocyte proliferation	GO:0070661	1	0.015
cell cycle arrest	GO:0007050	1	0.015
phosphorylation	GO:0016310	69	0.015
regulation of circadian rhythm	GO:0042752	4	0.015
cellular monovalent inorganic cation homeostasis	GO:0030004	2	0.015
regulation of signaling	GO:0023051	235	0.015
regulation of cell migration	GO:0030334	40	0.015
actin polymerization or depolymerization	GO:0008154	2	0.015
behavior	GO:0007610	74	0.015
regulation of response to nutrient levels	GO:0032107	1	0.015
negative regulation of protein serine threonine kinase activity	GO:0071901	2	0.015
kidney development	GO:0001822	92	0.015
cellular amine metabolic process	GO:0044106	2	0.015
cellular response to lipid	GO:0071396	39	0.015
cognition	GO:0050890	1	0.015	Mouse
regulation of extrinsic apoptotic signaling pathway in absence of ligand	GO:2001239	1	0.015
anterior posterior pattern specification	GO:0009952	152	0.015	Zebrafish
epithelial tube morphogenesis	GO:0060562	148	0.015	Zebrafish
positive regulation of cytoskeleton organization	GO:0051495	3	0.015
synapse organization	GO:0050808	21	0.014	Fly
regulation of protein complex disassembly	GO:0043244	1	0.014
mesenchymal cell differentiation	GO:0048762	87	0.014
lamellipodium assembly	GO:0030032	1	0.014
regulation of cell communication	GO:0010646	232	0.014
regulation of microtubule cytoskeleton organization	GO:0070507	3	0.014
positive regulation of cellular biosynthetic process	GO:0031328	68	0.014
inorganic ion transmembrane transport	GO:0098660	57	0.014	Zebrafish Worm Fly
regulation of ion transport	GO:0043269	22	0.014
canonical wnt signaling pathway	GO:0060070	48	0.014
response to uv	GO:0009411	3	0.014
dorsal ventral pattern formation	GO:0009953	125	0.014
locomotor rhythm	GO:0045475	3	0.014
endocrine process	GO:0050886	2	0.014
cellular ketone metabolic process	GO:0042180	11	0.014
regulation of gene expression	GO:0010468	265	0.014
positive regulation of cellular metabolic process	GO:0031325	94	0.014
response to oxidative stress	GO:0006979	11	0.014
stem cell differentiation	GO:0048863	117	0.014
negative regulation of cellular biosynthetic process	GO:0031327	55	0.014
innate immune response	GO:0045087	13	0.014
positive regulation of embryonic development	GO:0040019	3	0.014
vasculature development	GO:0001944	278	0.014
regionalization	GO:0003002	274	0.014	Zebrafish
regulation of protein catabolic process	GO:0042176	1	0.014
positive regulation of purine nucleotide catabolic process	GO:0033123	1	0.013
regulation of nucleic acid templated transcription	GO:1903506	213	0.013
protein polymerization	GO:0051258	4	0.013
wound healing	GO:0042060	90	0.013
regulation of synaptic plasticity	GO:0048167	1	0.013
lymphocyte proliferation	GO:0046651	1	0.013
cellular response to xenobiotic stimulus	GO:0071466	35	0.013
cellular response to extracellular stimulus	GO:0031668	2	0.013
cell cycle g2 m phase transition	GO:0044839	4	0.013
regulation of photoreceptor cell differentiation	GO:0046532	2	0.013
metal ion homeostasis	GO:0055065	26	0.013	Zebrafish
protein metabolic process	GO:0019538	183	0.013	Worm
synapse assembly	GO:0007416	9	0.013	Fly
cellular response to endogenous stimulus	GO:0071495	68	0.013
mechanoreceptor differentiation	GO:0042490	37	0.013
nuclear export	GO:0051168	1	0.013
neuron projection regeneration	GO:0031102	16	0.013
regulation of cell activation	GO:0050865	1	0.013
regulation of nucleoside metabolic process	GO:0009118	2	0.013
nucleoside metabolic process	GO:0009116	11	0.013	Zebrafish Worm Fly
mononuclear cell proliferation	GO:0032943	1	0.013
protein modification process	GO:0036211	100	0.013
fatty acid biosynthetic process	GO:0006633	4	0.013
blood vessel development	GO:0001568	246	0.013
retina development in camera type eye	GO:0060041	146	0.012
regulation of cellular component movement	GO:0051270	55	0.012
anion transport	GO:0006820	38	0.012
negative regulation of wnt signaling pathway	GO:0030178	30	0.012
purine nucleotide metabolic process	GO:0006163	27	0.012	Zebrafish Worm Fly
regulation of reproductive process	GO:2000241	4	0.012
negative regulation of cell migration	GO:0030336	17	0.012
regulation of locomotion	GO:0040012	55	0.012
regulation of cell differentiation	GO:0045595	142	0.012
regulation of actin filament based movement	GO:1903115	1	0.012
muscle system process	GO:0003012	20	0.012	Worm
axon guidance	GO:0007411	86	0.012
regulation of neuron differentiation	GO:0045664	56	0.012
liver development	GO:0001889	96	0.012
regulation of heart growth	GO:0060420	2	0.012
multicellular organismal response to stress	GO:0033555	2	0.012
positive regulation of nucleoside metabolic process	GO:0045979	1	0.012
kupffer s vesicle development	GO:0070121	50	0.012
regulation of calcium ion transport	GO:0051924	2	0.012
organophosphate metabolic process	GO:0019637	37	0.012	Zebrafish Worm Fly
negative regulation of map kinase activity	GO:0043407	2	0.012
regulation of cell size	GO:0008361	29	0.012
regulation of cellular component size	GO:0032535	30	0.012
cell cycle g1 s phase transition	GO:0044843	1	0.012
response to ketone	GO:1901654	1	0.012
skeletal system morphogenesis	GO:0048705	102	0.012
intracellular signal transduction	GO:0035556	85	0.012
cellular response to biotic stimulus	GO:0071216	3	0.012
regulation of fibroblast growth factor receptor signaling pathway	GO:0040036	20	0.012
gtp metabolic process	GO:0046039	4	0.012
positive regulation of signal transduction	GO:0009967	56	0.012
regulation of neurotransmitter transport	GO:0051588	1	0.012
negative regulation of macromolecule metabolic process	GO:0010605	76	0.012
positive regulation of apoptotic signaling pathway	GO:2001235	1	0.012
cell growth	GO:0016049	57	0.012
positive regulation of cellular amine metabolic process	GO:0033240	0	0.012
renal tubule morphogenesis	GO:0061333	1	0.012
regulation of cell projection organization	GO:0031344	44	0.011
purine ribonucleoside metabolic process	GO:0046128	10	0.011	Zebrafish Worm Fly
negative regulation of sequestering of calcium ion	GO:0051283	4	0.011
regulation of neurogenesis	GO:0050767	87	0.011
somatic stem cell maintenance	GO:0035019	1	0.011
regulation of receptor mediated endocytosis	GO:0048259	4	0.011
positive regulation of synapse assembly	GO:0051965	1	0.011
cellular cation homeostasis	GO:0030003	17	0.011	Zebrafish
action potential	GO:0001508	19	0.011	Worm
positive regulation of molecular function	GO:0044093	33	0.011
neuromuscular process controlling balance	GO:0050885	3	0.011
blood circulation	GO:0008015	87	0.011	Zebrafish
cellular response to nutrient levels	GO:0031669	2	0.011
calcium mediated signaling	GO:0019722	2	0.011
lamellipodium organization	GO:0097581	1	0.011
cellular macromolecular complex assembly	GO:0034622	24	0.011
regulation of purine nucleotide catabolic process	GO:0033121	2	0.011
chemical homeostasis	GO:0048878	49	0.011	Zebrafish
purine nucleoside metabolic process	GO:0042278	10	0.011	Zebrafish Worm Fly
thigmotaxis	GO:0001966	5	0.011	Zebrafish
taxis	GO:0042330	109	0.011	Zebrafish
membrane invagination	GO:0010324	1	0.011
response to hydrogen peroxide	GO:0042542	3	0.011
negative regulation of signal transduction	GO:0009968	94	0.011
regulation of nucleotide catabolic process	GO:0030811	2	0.011
response to metal ion	GO:0010038	34	0.011
cardiac muscle tissue development	GO:0048738	48	0.010
regulation of cellular amino acid metabolic process	GO:0006521	0	0.010
establishment of endothelial barrier	GO:0061028	3	0.010
cellular catabolic process	GO:0044248	27	0.010	Zebrafish Worm Fly
wnt signaling pathway	GO:0016055	80	0.010
single organism catabolic process	GO:0044712	13	0.010	Zebrafish Worm Fly
regulation of sodium ion transport	GO:0002028	2	0.010
heterocycle catabolic process	GO:0046700	15	0.010	Zebrafish Worm Fly
positive regulation of canonical wnt signaling pathway	GO:0090263	4	0.010
mesenchyme development	GO:0060485	127	0.010
ectodermal placode development	GO:0071696	37	0.010
death	GO:0016265	121	0.010
regulation of cellular amine metabolic process	GO:0033238	0	0.010
positive regulation of cytosolic calcium ion concentration	GO:0007204	4	0.010
regulation of dna templated transcription in response to stress	GO:0043620	0	0.010
regulation of hormone levels	GO:0010817	21	0.010
cellular response to organic substance	GO:0071310	105	0.010
positive regulation of protein metabolic process	GO:0051247	23	0.010
embryonic skeletal system morphogenesis	GO:0048704	93	0.010

atp1a3b disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.063
nervous system disease	DOID:863	0.028
cancer	DOID:162	0.018
organ system cancer	DOID:0050686	0.018
disease of cellular proliferation	DOID:14566	0.018

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