IMP: Integrative Multi-species Prediction

Danio rerio

14 known processes

npm1

nucleophosmin 1

(Aliases: npm1a,sb:cb487)

Ensembl: ENSDARG00000014329
ZFIN: ZDB-GENE-021028-1
Entrez: 266985
UniProtKB: Q7T362

Process Predictions
Disease Predictions

npm1 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
ribosome biogenesis	GO:0042254	9	0.922	Mouse
nuclear export	GO:0051168	1	0.888	Mouse
ribonucleoprotein complex biogenesis	GO:0022613	13	0.847	Mouse
hematopoietic or lymphoid organ development	GO:0048534	191	0.806
hemopoiesis	GO:0030097	183	0.766
cellular nitrogen compound metabolic process	GO:0034641	290	0.730	Human Mouse
organelle organization	GO:0006996	227	0.687	Human Mouse
immune system development	GO:0002520	191	0.630
cellular macromolecule metabolic process	GO:0044260	391	0.629	Human Mouse
immune system process	GO:0002376	241	0.585
rna processing	GO:0006396	25	0.561	Mouse
ribosomal small subunit biogenesis	GO:0042274	2	0.553	Mouse
nitrogen compound metabolic process	GO:0006807	319	0.530	Human Mouse
heterocycle metabolic process	GO:0046483	290	0.524	Human Mouse
nuclear transport	GO:0051169	4	0.499	Human Mouse
positive regulation of translation	GO:0045727	1	0.482	Human
microtubule organizing center organization	GO:0031023	1	0.416	Human Mouse
organic cyclic compound metabolic process	GO:1901360	301	0.404	Human Mouse
cellular aromatic compound metabolic process	GO:0006725	295	0.375	Human Mouse
nucleic acid metabolic process	GO:0090304	244	0.336	Human Mouse
rna metabolic process	GO:0016070	219	0.334	Human Mouse
gene expression	GO:0010467	252	0.325	Human Mouse
cellular macromolecule biosynthetic process	GO:0034645	224	0.251	Human
establishment of localization	GO:0051234	244	0.244	Human Mouse
regulation of biological quality	GO:0065008	263	0.238	Mouse
ncrna metabolic process	GO:0034660	12	0.229
centrosome cycle	GO:0007098	1	0.219	Human Mouse
aromatic compound biosynthetic process	GO:0019438	217	0.195	Human
single organism organelle organization	GO:1902589	199	0.187	Human Mouse
apoptotic process	GO:0006915	116	0.177	Human
regulation of deoxyribonuclease activity	GO:0032070	1	0.170	Human
macromolecule biosynthetic process	GO:0009059	227	0.163	Human
cellular localization	GO:0051641	97	0.156	Human Mouse
homeostatic process	GO:0042592	142	0.143	Mouse
cell migration	GO:0016477	237	0.138
cell proliferation	GO:0008283	80	0.127	Human Mouse
cellular component biogenesis	GO:0044085	178	0.123	Human Mouse
organelle assembly	GO:0070925	110	0.121	Human
regulation of macromolecule metabolic process	GO:0060255	317	0.119	Human Mouse
response to chemical	GO:0042221	320	0.116	Human
larval development	GO:0002164	2	0.116
aging	GO:0007568	2	0.113	Human
cell cycle	GO:0007049	93	0.109	Human Mouse
positive regulation of cell cycle	GO:0045787	3	0.106	Mouse
regulation of mrna processing	GO:0050684	3	0.104	Mouse
regulation of multicellular organism growth	GO:0040014	4	0.100
cell motility	GO:0048870	244	0.098
maturation of ssu rrna	GO:0030490	1	0.093
rrna metabolic process	GO:0016072	8	0.091
negative regulation of metabolic process	GO:0009892	86	0.091	Human Mouse
cellular protein metabolic process	GO:0044267	129	0.090	Human Mouse
cellular nitrogen compound biosynthetic process	GO:0044271	218	0.090	Human
cell activation	GO:0001775	16	0.088
organic substance biosynthetic process	GO:1901576	289	0.088	Human
regulation of mrna splicing via spliceosome	GO:0048024	3	0.087	Mouse
maintenance of location	GO:0051235	4	0.087
protein modification process	GO:0036211	100	0.084	Human Mouse
death	GO:0016265	121	0.083	Human
programmed cell death	GO:0012501	119	0.082	Human
locomotion	GO:0040011	313	0.081
centrosome organization	GO:0051297	1	0.079	Human Mouse
digestive system development	GO:0055123	289	0.078
chromosome organization	GO:0051276	31	0.074	Human
rna splicing via transesterification reactions with bulged adenosine as nucleophile	GO:0000377	10	0.071	Mouse
macromolecule modification	GO:0043412	111	0.071	Human Mouse
protein methylation	GO:0006479	13	0.071
cellular component movement	GO:0006928	335	0.068
regulation of cellular macromolecule biosynthetic process	GO:2000112	222	0.068	Human
nucleocytoplasmic transport	GO:0006913	4	0.068	Human Mouse
er nucleus signaling pathway	GO:0006984	2	0.066
nucleobase containing compound metabolic process	GO:0006139	274	0.065	Human Mouse
mrna metabolic process	GO:0016071	20	0.063	Mouse
growth	GO:0040007	174	0.063	Mouse
translational initiation	GO:0006413	3	0.063
cell death	GO:0008219	121	0.063	Human
regulation of response to stimulus	GO:0048583	269	0.060	Human Mouse
regulation of translational initiation	GO:0006446	1	0.060	Human
response to stress	GO:0006950	263	0.059	Human Mouse
maturation of ssu rrna from tricistronic rrna transcript ssu rrna 5 8s rrna lsu rrna	GO:0000462	1	0.058
organelle localization	GO:0051640	49	0.058	Mouse
negative regulation of biological process	GO:0048519	304	0.056	Human Mouse
tube morphogenesis	GO:0035239	349	0.055
cell aging	GO:0007569	2	0.054	Human
response to external biotic stimulus	GO:0043207	97	0.054
cellular response to dsrna	GO:0071359	1	0.054	Human
chromatin organization	GO:0006325	22	0.053	Human
protein metabolic process	GO:0019538	183	0.049	Human Mouse
rrna processing	GO:0006364	7	0.049
embryo development ending in birth or egg hatching	GO:0009792	271	0.049
establishment of localization in cell	GO:0051649	77	0.049	Human Mouse
cellular response to stress	GO:0033554	62	0.049	Human Mouse
regulation of biosynthetic process	GO:0009889	250	0.049	Human Mouse
positive regulation of cellular protein metabolic process	GO:0032270	22	0.048	Human Mouse
dna metabolic process	GO:0006259	27	0.048	Human
localization of cell	GO:0051674	244	0.047
muscle structure development	GO:0061061	196	0.045
macromolecular complex subunit organization	GO:0043933	74	0.045	Human
cellular response to organic substance	GO:0071310	105	0.043	Human
regulation of developmental process	GO:0050793	247	0.043	Mouse
positive regulation of cellular process	GO:0048522	201	0.043	Human Mouse
response to organic substance	GO:0010033	153	0.042	Human
biosynthetic process	GO:0009058	294	0.041	Human Mouse
positive regulation of biosynthetic process	GO:0009891	68	0.041	Human Mouse
cell surface receptor signaling pathway	GO:0007166	325	0.038
regulation of cellular metabolic process	GO:0031323	320	0.037	Human Mouse
multi organism process	GO:0051704	134	0.037
ncrna processing	GO:0034470	8	0.037
nucleic acid templated transcription	GO:0097659	181	0.036	Human
rna biosynthetic process	GO:0032774	181	0.036	Human
spindle assembly	GO:0051225	2	0.036
positive regulation of cellular metabolic process	GO:0031325	94	0.036	Human Mouse
regulation of nucleobase containing compound metabolic process	GO:0019219	250	0.035	Human Mouse
transport	GO:0006810	220	0.034	Human Mouse
regulation of dna catabolic process	GO:1903624	1	0.033	Human
microtubule cytoskeleton organization	GO:0000226	33	0.033	Human Mouse
cytoskeleton organization	GO:0007010	96	0.033	Human Mouse
regulation of signaling	GO:0023051	235	0.032	Mouse
developmental process involved in reproduction	GO:0003006	27	0.031
cellular response to chemical stimulus	GO:0070887	157	0.030	Human
embryonic cranial skeleton morphogenesis	GO:0048701	90	0.029
digestive tract development	GO:0048565	265	0.028
cell cycle process	GO:0022402	53	0.028	Human Mouse
multicellular organism growth	GO:0035264	4	0.028
cell growth	GO:0016049	57	0.027	Mouse
regulation of gene expression	GO:0010468	265	0.027	Human Mouse
single organism metabolic process	GO:0044710	217	0.027	Human
determination of heart left right asymmetry	GO:0061371	117	0.027
microtubule based process	GO:0007017	60	0.027	Human Mouse
regulation of macromolecule biosynthetic process	GO:0010556	225	0.027	Human
negative regulation of mrna splicing via spliceosome	GO:0048025	1	0.027	Mouse
cellular protein modification process	GO:0006464	100	0.026	Human Mouse
intracellular transport	GO:0046907	32	0.026	Human Mouse
establishment of organelle localization	GO:0051656	45	0.026	Mouse
morphogenesis of an epithelium	GO:0002009	333	0.025
b cell activation	GO:0042113	2	0.025
transcription dna templated	GO:0006351	181	0.025	Human
organic cyclic compound biosynthetic process	GO:1901362	223	0.025	Human
regulation of multicellular organismal process	GO:0051239	277	0.025
regulation of transcription dna templated	GO:0006355	213	0.025	Human
negative regulation of cellular metabolic process	GO:0031324	77	0.025	Human Mouse
negative regulation of cellular process	GO:0048523	283	0.025	Human Mouse
protein localization	GO:0008104	40	0.025	Human Mouse
reproductive process	GO:0022414	40	0.024
regulation of cellular protein metabolic process	GO:0032268	52	0.023	Human Mouse
centrosome duplication	GO:0051298	1	0.023	Human Mouse
cellular biosynthetic process	GO:0044249	286	0.023	Human Mouse
mononuclear cell proliferation	GO:0032943	1	0.023
regulation of cell communication	GO:0010646	232	0.022	Mouse
nucleobase containing compound biosynthetic process	GO:0034654	205	0.022	Human
ribonucleoside triphosphate biosynthetic process	GO:0009201	2	0.022
regulation of cell death	GO:0010941	103	0.021	Human
intracellular signal transduction	GO:0035556	85	0.021	Mouse
lipid storage	GO:0019915	1	0.021
single organism transport	GO:0044765	206	0.021	Mouse
hematopoietic progenitor cell differentiation	GO:0002244	23	0.021
stem cell development	GO:0048864	82	0.020	Mouse
positive regulation of biological process	GO:0048518	253	0.020	Human Mouse
regulation of rna biosynthetic process	GO:2001141	213	0.019	Human
heterocycle biosynthetic process	GO:0018130	215	0.019	Human
macromolecule methylation	GO:0043414	19	0.019
regulation of cell cycle	GO:0051726	52	0.019	Human Mouse
amine metabolic process	GO:0009308	2	0.018
enzyme linked receptor protein signaling pathway	GO:0007167	106	0.018
response to biotic stimulus	GO:0009607	97	0.018
stem cell differentiation	GO:0048863	117	0.018	Mouse
dna catabolic process	GO:0006308	1	0.017	Human
multicellular organism reproduction	GO:0032504	35	0.017
single organism localization	GO:1902578	225	0.017	Mouse
regulation of nitrogen compound metabolic process	GO:0051171	251	0.017	Human Mouse
negative regulation of macromolecule metabolic process	GO:0010605	76	0.016	Human Mouse
cellular process involved in reproduction in multicellular organism	GO:0022412	28	0.016
regulation of tube size	GO:0035150	2	0.016
gamete generation	GO:0007276	33	0.016
regulation of nuclease activity	GO:0032069	1	0.016	Human
regulation of signal transduction	GO:0009966	225	0.016	Mouse
negative regulation of programmed cell death	GO:0043069	58	0.016	Human
regulation of dna damage response signal transduction by p53 class mediator	GO:0043516	4	0.015	Mouse
negative regulation of mrna metabolic process	GO:1903312	3	0.015	Mouse
cellular component assembly involved in morphogenesis	GO:0010927	107	0.015
determination of left right symmetry	GO:0007368	179	0.015
developmental growth	GO:0048589	166	0.015
response to virus	GO:0009615	21	0.015
regulation of metabolic process	GO:0019222	359	0.015	Human Mouse
single organism intracellular transport	GO:1902582	25	0.015	Mouse
regulation of mrna metabolic process	GO:1903311	6	0.015	Mouse
regulation of organelle organization	GO:0033043	29	0.014	Human Mouse
histone modification	GO:0016570	20	0.014
nucleoside biosynthetic process	GO:0009163	2	0.014
generation of neurons	GO:0048699	385	0.014
embryonic heart tube development	GO:0035050	133	0.014
posttranscriptional gene silencing	GO:0016441	3	0.014
regulation of apoptotic process	GO:0042981	98	0.014	Human
protein alkylation	GO:0008213	13	0.014
ribosome assembly	GO:0042255	1	0.013
g1 s transition of mitotic cell cycle	GO:0000082	1	0.013
rna splicing via transesterification reactions	GO:0000375	10	0.013	Mouse
organonitrogen compound metabolic process	GO:1901564	74	0.013
regulation of programmed cell death	GO:0043067	101	0.013	Human
leukocyte proliferation	GO:0070661	1	0.013
positive regulation of metabolic process	GO:0009893	108	0.013	Human Mouse
pyrimidine containing compound biosynthetic process	GO:0072528	2	0.013
negative regulation of gene expression	GO:0010629	65	0.013	Mouse
regulation of signal transduction by p53 class mediator	GO:1901796	9	0.013	Mouse
regulation of growth	GO:0040008	42	0.012
internal peptidyl lysine acetylation	GO:0018393	2	0.012
negative regulation of cell death	GO:0060548	60	0.012	Human
gastrulation	GO:0007369	208	0.012
response to endogenous stimulus	GO:0009719	83	0.012
positive regulation of transport	GO:0051050	2	0.012
organic substance catabolic process	GO:1901575	28	0.012	Human
macromolecule localization	GO:0033036	54	0.012	Human Mouse
bicarbonate transport	GO:0015701	4	0.012
signal transduction by p53 class mediator	GO:0072331	13	0.012	Mouse
signal transduction	GO:0007165	455	0.012	Mouse
regulation of rna metabolic process	GO:0051252	224	0.011	Human Mouse
rna export from nucleus	GO:0006405	1	0.011	Mouse
reciprocal meiotic recombination	GO:0007131	1	0.011
regulation of cell differentiation	GO:0045595	142	0.011	Mouse
small molecule metabolic process	GO:0044281	77	0.011
negative regulation of mrna processing	GO:0050686	1	0.011	Mouse
positive regulation of developmental process	GO:0051094	50	0.011
embryonic pattern specification	GO:0009880	44	0.011
regulation of cell activation	GO:0050865	1	0.011
response to other organism	GO:0051707	97	0.011
embryonic heart tube morphogenesis	GO:0003143	108	0.011
mitotic cell cycle	GO:0000278	64	0.011
protein acetylation	GO:0006473	2	0.011
ribonucleoside biosynthetic process	GO:0042455	2	0.010
exocrine pancreas development	GO:0031017	28	0.010
rna modification	GO:0009451	2	0.010
transmembrane transport	GO:0055085	120	0.010
zymogen activation	GO:0031638	3	0.010
digestive tract morphogenesis	GO:0048546	231	0.010
regulation of cardiac muscle contraction	GO:0055117	2	0.010
heart looping	GO:0001947	94	0.010

npm1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease	DO term ID	Probability	Func Analog Org
disease of anatomical entity	DOID:7	0.108
musculoskeletal system disease	DOID:17	0.018
sensory system disease	DOID:0050155	0.011
nervous system disease	DOID:863	0.011
disease of cellular proliferation	DOID:14566	0.011	Human

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