IMP: Integrative Multi-species Prediction

Danio rerio

25 known processes

fgf4

fibroblast growth factor 4

(Aliases: MGC158215)

Ensembl: ENSDARG00000068095
Entrez: 570435
ZFIN: ZDB-GENE-001006-1
UniProtKB: Q9DFC9

Process Predictions
Disease Predictions

fgf4 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
chordate embryonic development	GO:0043009	271	0.943
tube morphogenesis	GO:0035239	349	0.864
otic vesicle morphogenesis	GO:0071600	34	0.807	Zebrafish
neural tube development	GO:0021915	62	0.750
locomotion	GO:0040011	313	0.724	Zebrafish Worm
embryonic skeletal system development	GO:0048706	97	0.721
connective tissue development	GO:0061448	99	0.719	Human Zebrafish Mouse
embryonic cranial skeleton morphogenesis	GO:0048701	90	0.675
cell surface receptor signaling pathway	GO:0007166	325	0.670	Human Zebrafish Mouse Worm
endocrine system development	GO:0035270	65	0.663	Zebrafish
neuron differentiation	GO:0030182	353	0.654	Zebrafish Worm
cellular response to growth factor stimulus	GO:0071363	39	0.648	Human Mouse Worm
positive regulation of macromolecule biosynthetic process	GO:0010557	59	0.634	Mouse
regulation of cell differentiation	GO:0045595	142	0.625	Zebrafish Mouse Worm
determination of bilateral symmetry	GO:0009855	204	0.621
determination of left right symmetry	GO:0007368	179	0.605
cell motility	GO:0048870	244	0.576	Zebrafish
kupffer s vesicle development	GO:0070121	50	0.531
gastrulation	GO:0007369	208	0.518
tissue remodeling	GO:0048771	4	0.510	Zebrafish
positive regulation of cellular metabolic process	GO:0031325	94	0.495	Human Mouse
response to organic substance	GO:0010033	153	0.489	Human Mouse Worm
otic placode formation	GO:0043049	23	0.475	Zebrafish
macromolecule biosynthetic process	GO:0009059	227	0.464	Mouse
midbrain development	GO:0030901	28	0.463	Zebrafish
appendage morphogenesis	GO:0035107	56	0.447	Zebrafish Mouse
embryonic organ development	GO:0048568	381	0.437	Zebrafish
response to endogenous stimulus	GO:0009719	83	0.425	Human Mouse Worm
embryonic eye morphogenesis	GO:0048048	30	0.408
head development	GO:0060322	303	0.403	Zebrafish
cartilage development	GO:0051216	96	0.400	Human Zebrafish Mouse
response to bacterium	GO:0009617	58	0.392
cellular biosynthetic process	GO:0044249	286	0.391	Mouse
negative regulation of cellular process	GO:0048523	283	0.378	Zebrafish Mouse Worm
response to biotic stimulus	GO:0009607	97	0.375
regulation of multicellular organismal development	GO:2000026	223	0.374	Zebrafish Worm
regulation of multicellular organismal process	GO:0051239	277	0.370	Zebrafish Worm
central nervous system development	GO:0007417	387	0.365	Zebrafish
camera type eye development	GO:0043010	222	0.364	Zebrafish
otic vesicle development	GO:0071599	42	0.362	Zebrafish
striated muscle tissue development	GO:0014706	110	0.358
cilium morphogenesis	GO:0060271	85	0.357
cell projection morphogenesis	GO:0048858	244	0.357
muscle structure development	GO:0061061	196	0.355
homeostatic process	GO:0042592	142	0.349	Zebrafish
cellular response to fibroblast growth factor stimulus	GO:0044344	22	0.346	Human Mouse Worm
cellular macromolecule biosynthetic process	GO:0034645	224	0.338	Mouse
axon guidance	GO:0007411	86	0.327	Worm
negative regulation of cell cycle	GO:0045786	14	0.327
aging	GO:0007568	2	0.327
embryonic heart tube morphogenesis	GO:0003143	108	0.324
pancreas development	GO:0031016	84	0.323
positive regulation of nucleobase containing compound metabolic process	GO:0045935	69	0.317	Mouse
negative regulation of multicellular organismal process	GO:0051241	69	0.316
response to chemical	GO:0042221	320	0.303	Human Mouse Worm
somitogenesis	GO:0001756	87	0.303
regulation of biosynthetic process	GO:0009889	250	0.302	Mouse
kidney development	GO:0001822	92	0.294
inner ear development	GO:0048839	126	0.293	Zebrafish
morphogenesis of an epithelium	GO:0002009	333	0.292	Zebrafish
cellular response to organic substance	GO:0071310	105	0.284	Human Mouse Worm
positive regulation of rna biosynthetic process	GO:1902680	57	0.281	Mouse
enzyme linked receptor protein signaling pathway	GO:0007167	106	0.280	Human Mouse Worm
mechanoreceptor differentiation	GO:0042490	37	0.275	Zebrafish
odontogenesis of dentin containing tooth	GO:0042475	1	0.269	Mouse
regulation of wnt signaling pathway calcium modulating pathway	GO:0008591	3	0.265
response to other organism	GO:0051707	97	0.264
cellular nitrogen compound metabolic process	GO:0034641	290	0.262	Mouse
ear development	GO:0043583	127	0.259	Zebrafish
cellular component movement	GO:0006928	335	0.256	Zebrafish Worm
positive regulation of metabolic process	GO:0009893	108	0.254	Human Mouse
sensory organ morphogenesis	GO:0090596	200	0.250	Zebrafish
cellular response to endogenous stimulus	GO:0071495	68	0.246	Human Mouse Worm
single organism metabolic process	GO:0044710	217	0.245	Human
heart development	GO:0007507	313	0.245
regulation of developmental process	GO:0050793	247	0.241	Zebrafish Mouse Worm
axonogenesis	GO:0007409	152	0.236	Worm
larval development	GO:0002164	2	0.235	Worm
muscle tissue development	GO:0060537	110	0.228
ear morphogenesis	GO:0042471	64	0.226	Zebrafish
positive regulation of macromolecule metabolic process	GO:0010604	93	0.226	Mouse
skin development	GO:0043588	54	0.223	Zebrafish
negative regulation of anterior neural cell fate commitment of the neural plate	GO:0022001	1	0.223
regulation of autophagy	GO:0010506	3	0.222
regulation of cell morphogenesis involved in differentiation	GO:0010769	38	0.218	Worm
sensory organ development	GO:0007423	393	0.216	Zebrafish
regulation of response to stimulus	GO:0048583	269	0.215	Human Zebrafish Worm
embryonic camera type eye development	GO:0031076	29	0.214
regulation of phospholipase c activity	GO:1900274	1	0.210
adenohypophysis development	GO:0021984	15	0.209	Zebrafish
cell fate specification	GO:0001708	68	0.208	Zebrafish
response to external stimulus	GO:0009605	264	0.207	Worm
negative regulation of anterior neural cell fate commitment of the neural plate by wnt signaling pathway	GO:0022002	1	0.205
digestive tract morphogenesis	GO:0048546	231	0.201
wound healing	GO:0042060	90	0.200	Zebrafish
response to growth factor	GO:0070848	39	0.199	Human Mouse Worm
nucleic acid metabolic process	GO:0090304	244	0.197	Mouse
embryonic pectoral fin morphogenesis	GO:0035118	24	0.197	Zebrafish
regulation of axonogenesis	GO:0050770	32	0.196	Worm
positive regulation of cellular biosynthetic process	GO:0031328	68	0.189	Mouse
odontogenesis	GO:0042476	9	0.189	Mouse
hindbrain development	GO:0030902	91	0.186	Zebrafish
cell migration involved in gastrulation	GO:0042074	79	0.184
cell projection organization	GO:0030030	284	0.183
t cell differentiation	GO:0030217	6	0.182
regulation of cell communication	GO:0010646	232	0.181	Human Zebrafish
epithelial cell differentiation	GO:0030855	116	0.180	Zebrafish
skeletal system development	GO:0001501	181	0.177	Human Zebrafish Mouse
skeletal system morphogenesis	GO:0048705	102	0.175	Mouse
localization of cell	GO:0051674	244	0.175	Zebrafish
lateral line development	GO:0048882	66	0.174	Zebrafish
immune system process	GO:0002376	241	0.173	Zebrafish
embryonic organ morphogenesis	GO:0048562	274	0.173	Zebrafish
regulation of cell cycle	GO:0051726	52	0.172
embryonic neurocranium morphogenesis	GO:0048702	15	0.172
muscle cell differentiation	GO:0042692	139	0.170
defense response to other organism	GO:0098542	33	0.168
regulation of nitrogen compound metabolic process	GO:0051171	251	0.166	Mouse
regulation of macromolecule biosynthetic process	GO:0010556	225	0.164	Mouse
gland development	GO:0048732	143	0.160	Zebrafish
cell morphogenesis involved in differentiation	GO:0000904	195	0.158	Worm
regulation of transcription from rna polymerase ii promoter involved in heart development	GO:1901213	15	0.157
regulation of cellular biosynthetic process	GO:0031326	245	0.156	Mouse
positive regulation of gene expression	GO:0010628	71	0.156	Mouse
positive regulation of erk1 and erk2 cascade	GO:0070374	2	0.154	Human
ameboidal type cell migration	GO:0001667	143	0.153
stem cell proliferation	GO:0072089	4	0.152	Human
generation of neurons	GO:0048699	385	0.150	Zebrafish Worm
fin regeneration	GO:0031101	51	0.148	Zebrafish
stem cell maintenance	GO:0019827	4	0.145	Mouse
hematopoietic or lymphoid organ development	GO:0048534	191	0.144	Zebrafish
epithelial cell proliferation involved in liver morphogenesis	GO:0072575	2	0.143
embryonic viscerocranium morphogenesis	GO:0048703	52	0.143
positive regulation of cell migration	GO:0030335	11	0.142	Zebrafish
regulation of transcription dna templated	GO:0006355	213	0.142	Mouse
spinal cord anterior posterior patterning	GO:0021512	1	0.139
positive regulation of biosynthetic process	GO:0009891	68	0.138	Mouse
cellular response to chemical stimulus	GO:0070887	157	0.137	Human Mouse Worm
rna biosynthetic process	GO:0032774	181	0.134	Mouse
cellular carbohydrate metabolic process	GO:0044262	4	0.134
dorsal ventral pattern formation	GO:0009953	125	0.134	Zebrafish
digestive system development	GO:0055123	289	0.133
signal transduction	GO:0007165	455	0.132	Human Zebrafish Mouse Worm
central nervous system neuron differentiation	GO:0021953	74	0.132
optic placode formation involved in camera type eye formation	GO:0046619	3	0.132
organic cyclic compound metabolic process	GO:1901360	301	0.129	Mouse
cell migration	GO:0016477	237	0.128	Zebrafish
oligodendrocyte differentiation	GO:0048709	23	0.126	Zebrafish
death	GO:0016265	121	0.125	Zebrafish Mouse
positive regulation of transcription dna templated	GO:0045893	57	0.123	Mouse
embryonic skeletal system morphogenesis	GO:0048704	93	0.122
cardiac muscle tissue development	GO:0048738	48	0.122
negative regulation of apoptotic process	GO:0043066	55	0.121	Zebrafish Mouse
regulation of cell morphogenesis	GO:0022604	42	0.119	Worm
actin filament based process	GO:0030029	64	0.118
cell death	GO:0008219	121	0.118	Zebrafish Mouse
eye field cell fate commitment involved in camera type eye formation	GO:0060898	3	0.116
positive regulation of response to stimulus	GO:0048584	80	0.116	Human Zebrafish
neuron development	GO:0048666	262	0.116	Zebrafish Worm
regulation of bmp signaling pathway involved in heart jogging	GO:2000223	12	0.115
biosynthetic process	GO:0009058	294	0.114	Mouse
cellular aromatic compound metabolic process	GO:0006725	295	0.113	Mouse
regulation of locomotion	GO:0040012	55	0.113	Zebrafish Worm
transcription from rna polymerase ii promoter	GO:0006366	80	0.113	Mouse
lymphocyte differentiation	GO:0030098	9	0.112
nucleic acid templated transcription	GO:0097659	181	0.112	Mouse
lateral line system development	GO:0048925	76	0.111	Zebrafish
maintenance of location	GO:0051235	4	0.111
embryo development ending in birth or egg hatching	GO:0009792	271	0.108
oxidation reduction process	GO:0055114	41	0.108
regulation of cell proliferation	GO:0042127	37	0.107	Human Mouse
regulation of multicellular organism growth	GO:0040014	4	0.106
positive regulation of biological process	GO:0048518	253	0.105	Human Zebrafish Mouse
multi organism process	GO:0051704	134	0.105
eye development	GO:0001654	277	0.104	Zebrafish
axon development	GO:0061564	166	0.104	Worm
embryonic camera type eye morphogenesis	GO:0048596	19	0.104
negative regulation of metabolic process	GO:0009892	86	0.103
rna metabolic process	GO:0016070	219	0.103	Mouse
periodic partitioning	GO:0007365	1	0.103
bmp signaling pathway involved in heart jogging	GO:0003303	14	0.100
positive regulation of cellular process	GO:0048522	201	0.100	Human Zebrafish Mouse
stem cell development	GO:0048864	82	0.099	Mouse
rhombomere 5 development	GO:0021571	4	0.099	Zebrafish
mesenchymal cell differentiation	GO:0048762	87	0.099
cell fate commitment	GO:0045165	99	0.098	Zebrafish
gall bladder development	GO:0061010	1	0.097
intracellular signal transduction	GO:0035556	85	0.096	Human
peptidyl lysine acetylation	GO:0018394	2	0.095
thrombocyte differentiation	GO:0002574	4	0.094
cell morphogenesis	GO:0000902	289	0.094
inner ear morphogenesis	GO:0042472	63	0.094	Zebrafish
autophagy	GO:0006914	4	0.093
ossification	GO:0001503	23	0.093
striated muscle cell differentiation	GO:0051146	129	0.092
carbohydrate derivative metabolic process	GO:1901135	61	0.091
urogenital system development	GO:0001655	97	0.091
regionalization	GO:0003002	274	0.089	Zebrafish
sensory perception of smell	GO:0007608	2	0.088
regulation of axon extension involved in axon guidance	GO:0048841	6	0.088	Worm
regulation of neuron projection development	GO:0010975	40	0.086	Worm
pigmentation	GO:0043473	85	0.086
negative regulation of mitosis	GO:0045839	3	0.085
nucleobase containing compound biosynthetic process	GO:0034654	205	0.085	Mouse
chemosensory behavior	GO:0007635	1	0.084
anterior head development	GO:0097065	2	0.083
nucleobase containing compound metabolic process	GO:0006139	274	0.083	Mouse
regulation of anterior head development	GO:2000742	2	0.083
renal system development	GO:0072001	94	0.082
determination of heart left right asymmetry	GO:0061371	117	0.082
regulation of nucleobase containing compound metabolic process	GO:0019219	250	0.081	Mouse
regulation of dna replication	GO:0006275	3	0.081
response to fibroblast growth factor	GO:0071774	22	0.081	Human Mouse Worm
cell part morphogenesis	GO:0032990	246	0.081
positive regulation of cellular component movement	GO:0051272	11	0.080	Zebrafish
organ formation	GO:0048645	17	0.080
cell morphogenesis involved in neuron differentiation	GO:0048667	163	0.080	Worm
pectoral fin morphogenesis	GO:0035138	29	0.079	Zebrafish
positive regulation of fibroblast growth factor receptor signaling pathway	GO:0045743	9	0.078
response to stress	GO:0006950	263	0.078	Zebrafish
regulation of anatomical structure morphogenesis	GO:0022603	130	0.078	Worm
specification of symmetry	GO:0009799	204	0.076
hepatocyte proliferation	GO:0072574	2	0.075
heart morphogenesis	GO:0003007	156	0.075
metencephalon development	GO:0022037	27	0.073	Zebrafish
mesoderm development	GO:0007498	88	0.073
hepatic duct development	GO:0061011	2	0.072
convergent extension involved in gastrulation	GO:0060027	71	0.072
pericardium development	GO:0060039	1	0.071
bmp signaling pathway involved in heart development	GO:0061312	15	0.071
taxis	GO:0042330	109	0.070	Worm
craniofacial suture morphogenesis	GO:0097094	2	0.070	Mouse
organic substance biosynthetic process	GO:1901576	289	0.070	Mouse
anatomical structure homeostasis	GO:0060249	36	0.069	Zebrafish
response to xenobiotic stimulus	GO:0009410	45	0.069
regulation of cell death	GO:0010941	103	0.069	Zebrafish Mouse
negative regulation of muscle tissue development	GO:1901862	2	0.069
apoptotic process	GO:0006915	116	0.069	Zebrafish Mouse
segment polarity determination	GO:0007367	1	0.068
negative regulation of feeding behavior	GO:2000252	2	0.068
regulation of cellular response to growth factor stimulus	GO:0090287	35	0.067
regulation of cellular carbohydrate metabolic process	GO:0010675	4	0.066
regulation of transcription from rna polymerase ii promoter	GO:0006357	114	0.066	Mouse
negative regulation of muscle organ development	GO:0048635	5	0.065
pectoral fin development	GO:0033339	50	0.065	Zebrafish
segmentation	GO:0035282	97	0.065
regulation of rna biosynthetic process	GO:2001141	213	0.065	Mouse
regulation of nucleic acid templated transcription	GO:1903506	213	0.064	Mouse
mesenchyme development	GO:0060485	127	0.064
regulation of signal transduction	GO:0009966	225	0.064	Human Zebrafish
regulation of metabolic process	GO:0019222	359	0.063	Human Mouse
tissue regeneration	GO:0042246	74	0.063	Zebrafish
anterior posterior pattern specification	GO:0009952	152	0.061	Zebrafish
cellular hormone metabolic process	GO:0034754	19	0.061
regulation of cellular component movement	GO:0051270	55	0.061	Zebrafish Worm
blood vessel morphogenesis	GO:0048514	216	0.061
regulation of organ growth	GO:0046620	3	0.061
fibroblast growth factor receptor signaling pathway	GO:0008543	22	0.059	Human Mouse Worm
regulation of stem cell differentiation	GO:2000736	4	0.059
positive regulation of transport	GO:0051050	2	0.059
negative regulation of kinase activity	GO:0033673	4	0.058
ectodermal placode morphogenesis	GO:0071697	32	0.058	Zebrafish
stem cell differentiation	GO:0048863	117	0.058	Mouse
morphogenesis of embryonic epithelium	GO:0016331	30	0.058
embryonic camera type eye formation	GO:0060900	10	0.057
proteolysis involved in cellular protein catabolic process	GO:0051603	3	0.057
positive regulation of cellular catabolic process	GO:0031331	3	0.057
striated muscle cell development	GO:0055002	108	0.057
heterocycle metabolic process	GO:0046483	290	0.056	Mouse
notochord development	GO:0030903	54	0.056
endocardial cushion formation	GO:0003272	2	0.055
regulation of molecular function	GO:0065009	70	0.055
aromatic compound biosynthetic process	GO:0019438	217	0.055	Mouse
nucleocytoplasmic transport	GO:0006913	4	0.055
regulation of tube size	GO:0035150	2	0.054
negative regulation of striated muscle tissue development	GO:0045843	2	0.054
eye morphogenesis	GO:0048592	144	0.054	Zebrafish
neural tube patterning	GO:0021532	33	0.053
regulation of programmed cell death	GO:0043067	101	0.053	Zebrafish Mouse
small molecule metabolic process	GO:0044281	77	0.052
regulation of macromolecule metabolic process	GO:0060255	317	0.052	Mouse
hair cell differentiation	GO:0035315	32	0.052	Zebrafish
neurological system process	GO:0050877	62	0.051
neuron projection development	GO:0031175	180	0.051	Worm
regulation of cell size	GO:0008361	29	0.051	Worm
positive regulation of catabolic process	GO:0009896	4	0.051
somite development	GO:0061053	96	0.050
neural plate development	GO:0001840	10	0.050
response to abiotic stimulus	GO:0009628	122	0.050
pronephros development	GO:0048793	69	0.050
modification dependent protein catabolic process	GO:0019941	3	0.050
optic placode formation	GO:0001743	4	0.050
regulation of response to nutrient levels	GO:0032107	1	0.049
post anal tail morphogenesis	GO:0036342	19	0.049
sensory perception of chemical stimulus	GO:0007606	3	0.049
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	42	0.049	Human Mouse Worm
positive regulation of cell communication	GO:0010647	56	0.048	Human Zebrafish
transport	GO:0006810	220	0.048
single organism biosynthetic process	GO:0044711	71	0.048
t cell activation	GO:0042110	6	0.048
epithelial tube morphogenesis	GO:0060562	148	0.047
negative regulation of biological process	GO:0048519	304	0.047	Zebrafish Mouse Worm
digestive tract development	GO:0048565	265	0.047
programmed cell death	GO:0012501	119	0.047	Zebrafish Mouse
negative regulation of gene expression	GO:0010629	65	0.046
locus ceruleus development	GO:0021703	3	0.046	Zebrafish
embryonic pattern specification	GO:0009880	44	0.046	Zebrafish
hard palate development	GO:0060022	4	0.046	Zebrafish
epithelial to mesenchymal transition	GO:0001837	21	0.045
stem cell division	GO:0017145	1	0.045
positive regulation of apoptotic process	GO:0043065	29	0.045
regulation of organ morphogenesis	GO:2000027	35	0.044
exocrine system development	GO:0035272	28	0.044
negative regulation of programmed cell death	GO:0043069	58	0.044	Zebrafish Mouse
embryonic digestive tract morphogenesis	GO:0048557	3	0.044
mediolateral intercalation	GO:0060031	3	0.044
regulation of stem cell proliferation	GO:0072091	2	0.043
gene expression	GO:0010467	252	0.042	Mouse
response to external biotic stimulus	GO:0043207	97	0.042
sensory system development	GO:0048880	76	0.042	Zebrafish
wnt signaling pathway involved in digestive tract morphogenesis	GO:0044333	4	0.041
brain development	GO:0007420	293	0.041	Zebrafish
heart looping	GO:0001947	94	0.041
cellular nitrogen compound biosynthetic process	GO:0044271	218	0.041	Mouse
rostrocaudal neural tube patterning	GO:0021903	29	0.041
forebrain regionalization	GO:0021871	4	0.041
macromolecule modification	GO:0043412	111	0.040	Mouse
pons development	GO:0021548	11	0.040	Zebrafish
cellular response to nutrient levels	GO:0031669	2	0.040
regulation of circadian rhythm	GO:0042752	4	0.040
regulation of heart morphogenesis	GO:2000826	17	0.040
regulation of apoptotic process	GO:0042981	98	0.040	Zebrafish Mouse
alcohol biosynthetic process	GO:0046165	2	0.040
regulation of nuclear division	GO:0051783	9	0.039
regulation of signaling	GO:0023051	235	0.038	Human Zebrafish
camera type eye morphogenesis	GO:0048593	108	0.038	Zebrafish
fin morphogenesis	GO:0033334	53	0.038	Zebrafish
otolith development	GO:0048840	32	0.038	Zebrafish
response to wounding	GO:0009611	116	0.038	Zebrafish
hemopoiesis	GO:0030097	183	0.038	Zebrafish
regulation of cartilage development	GO:0061035	7	0.038
fin development	GO:0033333	77	0.038	Zebrafish
regulation of protein import into nucleus	GO:0042306	2	0.037
transcription dna templated	GO:0006351	181	0.037	Mouse
regulation of cell fate specification	GO:0042659	20	0.037
inner ear receptor cell differentiation	GO:0060113	29	0.037	Zebrafish
heart contraction	GO:0060047	71	0.037
positive regulation of multicellular organismal process	GO:0051240	52	0.036	Zebrafish
bone remodeling	GO:0046849	2	0.036	Zebrafish
positive regulation of muscle tissue development	GO:1901863	1	0.036
retina morphogenesis in camera type eye	GO:0060042	79	0.036	Zebrafish
circadian sleep wake cycle sleep	GO:0050802	1	0.036
cell differentiation in spinal cord	GO:0021515	40	0.036
positive regulation of rna metabolic process	GO:0051254	59	0.035	Mouse
carbohydrate metabolic process	GO:0005975	12	0.035
protein import into nucleus	GO:0006606	3	0.035
nitrogen compound metabolic process	GO:0006807	319	0.035	Mouse
ectodermal placode development	GO:0071696	37	0.035	Zebrafish
regulation of insulin like growth factor receptor signaling pathway	GO:0043567	1	0.035
cell surface receptor signaling pathway involved in heart development	GO:0061311	20	0.034
cell substrate adhesion	GO:0031589	4	0.034
regulation of cell motility	GO:2000145	46	0.034	Zebrafish
regulation of extrinsic apoptotic signaling pathway	GO:2001236	3	0.033
positive regulation of cell activation	GO:0050867	1	0.033
developmental growth	GO:0048589	166	0.033	Zebrafish Worm
cellular response to external stimulus	GO:0071496	2	0.033
chondrocyte differentiation	GO:0002062	7	0.033
regulation of cell development	GO:0060284	100	0.033	Zebrafish Worm
regulation of binding	GO:0051098	3	0.033
cellular macromolecule metabolic process	GO:0044260	391	0.033	Mouse
otic vesicle formation	GO:0030916	27	0.033	Zebrafish
positive regulation of cell division	GO:0051781	2	0.033
hormone biosynthetic process	GO:0042446	3	0.033
regulation of biological quality	GO:0065008	263	0.032	Zebrafish Worm
regulation of cardiac muscle tissue development	GO:0055024	1	0.032
cellular localization	GO:0051641	97	0.032
cellular response to hypoxia	GO:0071456	1	0.032
single organism reproductive process	GO:0044702	40	0.032
regulation of transcription from rna polymerase ii promoter involved in determination of left right symmetry	GO:1900094	17	0.032
sensory perception of mechanical stimulus	GO:0050954	16	0.032
single organism organelle organization	GO:1902589	199	0.031
negative regulation of cell migration	GO:0030336	17	0.031
apoptotic process involved in morphogenesis	GO:0060561	2	0.031	Mouse
diencephalon development	GO:0021536	58	0.031	Zebrafish
regulation of axon extension	GO:0030516	24	0.031	Worm
extrinsic apoptotic signaling pathway in absence of ligand	GO:0097192	1	0.031
regulation of extent of cell growth	GO:0061387	29	0.031	Worm
sensory perception of sound	GO:0007605	9	0.030
positive regulation of protein kinase b signaling	GO:0051897	1	0.030
developmental growth involved in morphogenesis	GO:0060560	86	0.030	Worm
internal peptidyl lysine acetylation	GO:0018393	2	0.029
bmp signaling pathway involved in determination of left right symmetry	GO:0003154	14	0.029
carbohydrate biosynthetic process	GO:0016051	1	0.029
positive regulation of nitrogen compound metabolic process	GO:0051173	69	0.029	Mouse
regulation of protein ubiquitination	GO:0031396	3	0.029
sensory perception	GO:0007600	39	0.029
morphogenesis of an epithelial fold	GO:0060571	1	0.029
regulation of carbohydrate metabolic process	GO:0006109	4	0.029
positive regulation of cell differentiation	GO:0045597	30	0.029	Zebrafish
positive regulation of cytosolic calcium ion concentration	GO:0007204	4	0.029
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	68	0.029
multicellular organism growth	GO:0035264	4	0.028
cellular response to hormone stimulus	GO:0032870	39	0.028
regulation of fibroblast growth factor receptor signaling pathway	GO:0040036	20	0.028
positive regulation of nucleic acid templated transcription	GO:1903508	57	0.028	Mouse
regulation of heart growth	GO:0060420	2	0.027
regulation of establishment of protein localization	GO:0070201	4	0.027
negative regulation of cell death	GO:0060548	60	0.027	Zebrafish Mouse
epidermal cell differentiation	GO:0009913	36	0.027	Zebrafish
female sex differentiation	GO:0046660	4	0.027
neuroblast proliferation	GO:0007405	2	0.027
insulin like growth factor receptor signaling pathway	GO:0048009	4	0.027
nuclear transport	GO:0051169	4	0.027
regulation of cell activation	GO:0050865	1	0.027
regulation of primary metabolic process	GO:0080090	311	0.026	Mouse
regulation of mitosis	GO:0007088	9	0.026
regulation of immune system process	GO:0002682	34	0.026
cell cell signaling involved in cell fate commitment	GO:0045168	12	0.026
embryonic appendage morphogenesis	GO:0035113	30	0.026	Zebrafish Mouse
cellular biogenic amine metabolic process	GO:0006576	2	0.026
regulation of mesoderm development	GO:2000380	11	0.026
regulation of cytokine production	GO:0001817	3	0.026
midbrain hindbrain boundary development	GO:0030917	23	0.025
embryonic limb morphogenesis	GO:0030326	2	0.025	Mouse
vestibular receptor cell differentiation	GO:0060114	3	0.025	Zebrafish
cytoskeleton organization	GO:0007010	96	0.025
organ growth	GO:0035265	12	0.025
neuron projection morphogenesis	GO:0048812	161	0.025	Worm
mesenchyme morphogenesis	GO:0072132	5	0.025
negative regulation of signal transduction	GO:0009968	94	0.025
embryonic skeletal joint development	GO:0072498	3	0.024
peptidyl lysine methylation	GO:0018022	3	0.024
blood circulation	GO:0008015	87	0.024
apoptotic process involved in development	GO:1902742	2	0.024	Mouse
specification of organ identity	GO:0010092	2	0.024
regulation of neuron differentiation	GO:0045664	56	0.024	Zebrafish Worm
neuroblast differentiation	GO:0014016	1	0.024
cell cycle	GO:0007049	93	0.024
single organism localization	GO:1902578	225	0.024
regulation of neurogenesis	GO:0050767	87	0.024	Zebrafish Worm
steroid hormone mediated signaling pathway	GO:0043401	9	0.024
cell proliferation	GO:0008283	80	0.023	Human Zebrafish Mouse
endoderm development	GO:0007492	49	0.023
ketone biosynthetic process	GO:0042181	2	0.023
regulation of cellular metabolic process	GO:0031323	320	0.023	Human Mouse
microtubule cytoskeleton organization	GO:0000226	33	0.023
developmental induction	GO:0031128	10	0.023
sexual reproduction	GO:0019953	36	0.023
positive regulation of stem cell proliferation	GO:2000648	1	0.023
negative regulation of cellular biosynthetic process	GO:0031327	55	0.023
tube closure	GO:0060606	1	0.023
semicircular canal formation	GO:0060876	4	0.022
protein acetylation	GO:0006473	2	0.022
limb morphogenesis	GO:0035108	7	0.022	Mouse
cell growth	GO:0016049	57	0.022	Worm
regulation of bone mineralization	GO:0030500	2	0.022
establishment of localization	GO:0051234	244	0.022
spemann organizer formation	GO:0060061	10	0.022
regulation of epithelial to mesenchymal transition	GO:0010717	3	0.022
protein kinase b signaling	GO:0043491	9	0.022
axon extension	GO:0048675	45	0.022	Worm
embryonic heart tube development	GO:0035050	133	0.022
extrinsic apoptotic signaling pathway	GO:0097191	3	0.022
lipid storage	GO:0019915	1	0.022
signal transduction in absence of ligand	GO:0038034	1	0.022
regulation of rna metabolic process	GO:0051252	224	0.022	Mouse
pharyngeal system development	GO:0060037	18	0.022
regulation of embryonic development	GO:0045995	47	0.022
positive regulation of cell motility	GO:2000147	11	0.022	Zebrafish
hepaticobiliary system development	GO:0061008	98	0.021	Zebrafish
intracellular transport	GO:0046907	32	0.021
regulation of cellular macromolecule biosynthetic process	GO:2000112	222	0.021	Mouse
compound eye development	GO:0048749	2	0.021
cellular response to steroid hormone stimulus	GO:0071383	31	0.021
single organism transport	GO:0044765	206	0.021
defense response to bacterium	GO:0042742	22	0.021
endocardial cushion morphogenesis	GO:0003203	3	0.021
regulation of protein complex assembly	GO:0043254	3	0.021
positive regulation of molecular function	GO:0044093	33	0.021
positive regulation of cell adhesion	GO:0045785	1	0.021
defense response	GO:0006952	47	0.021
modification dependent macromolecule catabolic process	GO:0043632	3	0.021
liver development	GO:0001889	96	0.020	Zebrafish
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	22	0.020	Mouse
nephron development	GO:0072006	31	0.020
angiogenesis	GO:0001525	158	0.020
regulation of intracellular protein transport	GO:0033157	3	0.020
regulation of endodermal cell fate specification	GO:0042663	15	0.020
fatty acid oxidation	GO:0019395	1	0.020
positive regulation of mesenchymal cell proliferation	GO:0002053	1	0.020
regulation of catalytic activity	GO:0050790	55	0.020

fgf4 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease	DO term ID	Probability
musculoskeletal system disease	DOID:17	0.082
disease of anatomical entity	DOID:7	0.082
connective tissue disease	DOID:65	0.038
bone disease	DOID:0080001	0.038
bone development disease	DOID:0080006	0.038

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