Danio rerio

0 known processes

plek

pleckstrin

(Aliases: MGC66013,zgc:66013)

plek biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
larval developmentGO:000216420.120
superoxide metabolic processGO:000680120.094
biosynthetic processGO:00090582940.067
Human
cellular response to external stimulusGO:007149620.061
agingGO:000756820.058
positive regulation of transportGO:005105020.056
cellular biosynthetic processGO:00442492860.056
Human
multicellular organism growthGO:003526440.052
cellular component morphogenesisGO:00329893360.042
positive regulation of map kinase activityGO:004340630.042
actin polymerization or depolymerizationGO:000815420.041
Human Mouse
response to stressGO:00069502630.040
Human Mouse
establishment of protein localization to organelleGO:007259440.038
single organism membrane fusionGO:004480120.038
adult behaviorGO:003053420.038
cognitionGO:005089010.037
regulation of multicellular organism growthGO:004001440.037
maintenance of locationGO:005123540.037
protein importGO:001703830.036
i kappab kinase nf kappab signalingGO:000724940.035
regulation of wound healingGO:006104120.034
Mouse
establishment of synaptic vesicle localizationGO:009748010.034
regulation of protein transportGO:005122330.034
sensory organ developmentGO:00074233930.034
response to amino acidGO:004320020.033
organic cyclic compound metabolic processGO:19013603010.033
positive regulation of i kappab kinase nf kappab signalingGO:004312330.033
response to drugGO:004249330.033
cell part morphogenesisGO:00329902460.032
protein polymerizationGO:005125840.032
nucleocytoplasmic transportGO:000691340.032
regulation of signalingGO:00230512350.031
Human
regulation of reactive oxygen species metabolic processGO:200037720.031
regulation of cytoplasmic transportGO:190364940.031
regulation of establishment of protein localizationGO:007020140.031
small molecule metabolic processGO:0044281770.031
Human
regulation of metabolic processGO:00192223590.031
Human
guanosine containing compound catabolic processGO:190106920.031
nuclear transportGO:005116940.030
amine metabolic processGO:000930820.030
regulation of peptidyl tyrosine phosphorylationGO:005073010.030
regulation of mrna processingGO:005068430.030
digestive tract developmentGO:00485652650.030
protein localization to nucleusGO:003450430.030
cellular amine metabolic processGO:004410620.029
nitrogen compound metabolic processGO:00068073190.029
regulation of cellular amine metabolic processGO:003323800.028
tube morphogenesisGO:00352393490.028
organonitrogen compound metabolic processGO:1901564740.028
regulation of protein targetingGO:190353320.028
cell morphogenesisGO:00009022890.028
regulation of multicellular organismal processGO:00512392770.028
Mouse
protein targeting to nucleusGO:004474430.027
generation of neuronsGO:00486993850.027
regulation of intracellular protein transportGO:003315730.027
positive regulation of cellular amino acid metabolic processGO:004576400.027
single organism nuclear importGO:190259330.027
proteasomal protein catabolic processGO:001049820.027
organelle fusionGO:004828430.027
membrane fusionGO:006102520.027
heart developmentGO:00075073130.027
regulation of developmental processGO:00507932470.027
synaptic growth at neuromuscular junctionGO:005112420.026
nuclear importGO:005117030.026
neuron differentiationGO:00301823530.026
organic acid metabolic processGO:0006082310.026
tissue remodelingGO:004877140.026
synaptic vesicle transportGO:004848910.026
regulation of nucleocytoplasmic transportGO:004682220.026
chordate embryonic developmentGO:00430092710.026
gtp catabolic processGO:000618420.026
cell morphogenesis involved in neuron differentiationGO:00486671630.025
regulation of nucleotide catabolic processGO:003081120.025
exocytosisGO:000688710.025
Human Mouse
modification dependent macromolecule catabolic processGO:004363230.025
system processGO:00030081850.025
reactive oxygen species metabolic processGO:007259360.025
protein localization to plasma membraneGO:007265910.024
response to chemicalGO:00422213200.024
single organism metabolic processGO:00447102170.024
Human
cell surface receptor signaling pathwayGO:00071663250.024
Human Mouse
signal transductionGO:00071654550.024
Human Mouse
phagocytosisGO:000690930.024
cellular ketone metabolic processGO:0042180110.023
regulation of cellular amino acid metabolic processGO:000652100.023
cellular nitrogen compound metabolic processGO:00346412900.023
ear developmentGO:00435831270.023
nucleobase containing compound metabolic processGO:00061392740.023
proteolysis involved in cellular protein catabolic processGO:005160330.023
neuroblast proliferationGO:000740520.023
monovalent inorganic cation transportGO:0015672420.023
rna localizationGO:000640340.022
modification dependent protein catabolic processGO:001994130.022
regulation of biological qualityGO:00650082630.022
Human Mouse
regulation of synapse organizationGO:005080730.022
single organism organelle organizationGO:19025891990.022
Human Mouse
regulation of protein complex assemblyGO:004325430.022
Mouse
autophagyGO:000691440.022
regulation of cell shapeGO:000836010.022
gtp metabolic processGO:004603940.022
synaptic vesicle localizationGO:009747910.022
reactive oxygen species biosynthetic processGO:190340910.022
regionalizationGO:00030022740.022
cellular amino acid metabolic processGO:000652070.022
protein import into nucleusGO:000660630.021
stem cell proliferationGO:007208940.021
regulation of protein localization to nucleusGO:190018020.021
cellular response to extracellular stimulusGO:003166820.021
carboxylic acid metabolic processGO:0019752220.021
regulation of protein modification by small protein conjugation or removalGO:190332030.021
regulation of cellular ketone metabolic processGO:001056570.021
regulation of protein import into nucleusGO:004230620.021
eye developmentGO:00016542770.021
positive regulation of cellular processGO:00485222010.021
Human Mouse
positive regulation of cell cycleGO:004578730.020
regulation of i kappab kinase nf kappab signalingGO:004312240.020
anterior posterior pattern specificationGO:00099521520.020
oxoacid metabolic processGO:0043436310.020
axon developmentGO:00615641660.020
skeletal muscle tissue developmentGO:0007519670.020
regulation of cell communicationGO:00106462320.020
Human
cellular macromolecule metabolic processGO:00442603910.020
regulation of protein polymerizationGO:003227120.020
positive regulation of cellular catabolic processGO:003133130.020
regulation of macromolecule metabolic processGO:00602553170.020
neuron neuron synaptic transmissionGO:000727010.020
negative regulation of cytokine productionGO:000181810.020
cellular response to nutrient levelsGO:003166920.020
response to carbohydrateGO:000974330.020
negative regulation of catabolic processGO:000989530.019
gastrulationGO:00073692080.019
activation of mapk activityGO:000018730.019
cell projection organizationGO:00300302840.019
Human
regulation of nitrogen compound metabolic processGO:00511712510.019
cytokinesisGO:000091030.019
sequestering of metal ionGO:005123830.019
cellular response to chemical stimulusGO:00708871570.019
cytoplasm organizationGO:000702840.019
macromolecular complex disassemblyGO:003298410.019
Human Mouse
positive regulation of cellular amine metabolic processGO:003324000.019
morphogenesis of an epitheliumGO:00020093330.019
cellular response to starvationGO:000926710.019
cell motilityGO:00488702440.019
cell projection morphogenesisGO:00488582440.019
positive regulation of biological processGO:00485182530.019
Human Mouse
regulation of synaptic plasticityGO:004816710.018
heart contractionGO:0060047710.018
regulation of gene expressionGO:00104682650.018
actin filament polymerizationGO:003004120.018
regulation of tube sizeGO:003515020.018
regulation of cell activationGO:005086510.018
Mouse
ubiquitin dependent protein catabolic processGO:000651130.018
regulation of purine nucleotide catabolic processGO:003312120.018
cell morphogenesis involved in differentiationGO:00009041950.018
inner ear developmentGO:00488391260.018
regulation of cytokine productionGO:000181730.018
cell deathGO:00082191210.018
regulation of signal transductionGO:00099662250.018
Human
nuclear exportGO:005116810.018
inorganic anion transportGO:0015698250.017
cellular protein catabolic processGO:004425740.017
embryonic organ morphogenesisGO:00485622740.017
negative regulation of kinase activityGO:003367340.017
protein complex disassemblyGO:004324110.017
Human Mouse
single organism localizationGO:19025782250.017
Human Mouse
positive regulation of cell adhesionGO:004578510.017
single organism transportGO:00447652060.017
Human Mouse
proteasome mediated ubiquitin dependent protein catabolic processGO:004316120.017
cell cycle g1 s phase transitionGO:004484310.017
cytoskeleton dependent cytokinesisGO:006164030.017
regulation of primary metabolic processGO:00800903110.017
Human
positive regulation of catabolic processGO:000989640.017
muscle structure developmentGO:00610611960.017
b cell activationGO:004211320.017
positive regulation of cytosolic calcium ion concentrationGO:000720440.017
positive regulation of stress activated mapk cascadeGO:003287430.017
regulation of alternative mrna splicing via spliceosomeGO:000038110.017
response to hydrogen peroxideGO:004254230.017
embryonic organ developmentGO:00485683810.016
single organism biosynthetic processGO:0044711710.016
Human
organic substance biosynthetic processGO:19015762890.016
Human
digestive system developmentGO:00551232890.016
regulation of nucleobase containing compound metabolic processGO:00192192500.016
rna metabolic processGO:00160702190.016
phosphate containing compound metabolic processGO:00067961080.016
Human
oocyte anterior posterior axis specificationGO:000731440.016
regulation of response to stimulusGO:00485832690.016
Human Mouse
regulation of cellular metabolic processGO:00313233200.016
Human
homeostatic processGO:00425921420.016
neuron developmentGO:00486662620.016
cellular component movementGO:00069283350.016
heterocycle metabolic processGO:00464832900.016
nucleic acid transportGO:005065720.016
extrinsic apoptotic signaling pathwayGO:009719130.016
multi organism processGO:00517041340.016
regulation of meiotic cell cycleGO:005144510.016
protein metabolic processGO:00195381830.016
response to abiotic stimulusGO:00096281220.016
regulation of multicellular organismal developmentGO:20000262230.016
spermatid developmentGO:000728620.015
cellular aromatic compound metabolic processGO:00067252950.015
chemosensory behaviorGO:000763510.015
lipid storageGO:001991510.015
digestive tract morphogenesisGO:00485462310.015
regulation of reproductive processGO:200024140.015
regulation of muscle contractionGO:000693730.015
maternal determination of anterior posterior axis embryoGO:000835840.015
cellular component assembly involved in morphogenesisGO:00109271070.015
regulation of protein catabolic processGO:004217610.015
cellular nitrogen compound biosynthetic processGO:00442712180.015
neuron projection morphogenesisGO:00488121610.015
gene expressionGO:00104672520.015
regulation of bindingGO:005109830.014
regulation of mrna splicing via spliceosomeGO:004802430.014
sensory perception of chemical stimulusGO:000760630.014
sleepGO:003043110.014
regulation of anatomical structure morphogenesisGO:00226031300.014
transportGO:00068102200.014
Human Mouse
regulation of biosynthetic processGO:00098892500.014
Human
cellular component disassemblyGO:002241110.014
Human Mouse
cytoskeleton organizationGO:0007010960.014
Human Mouse
cellular response to reactive oxygen speciesGO:003461420.014
mitotic cytokinesisGO:000028130.014
immune system processGO:00023762410.014
Human
nerve developmentGO:0021675450.014
brain developmentGO:00074202930.014
neurotransmitter transportGO:000683620.014
macromolecule biosynthetic processGO:00090592270.014
neurological system processGO:0050877620.014
compound eye developmentGO:004874920.014
response to external stimulusGO:00096052640.014
Mouse
growthGO:00400071740.014
blood circulationGO:0008015870.014
regulation of neurotransmitter secretionGO:004692810.014
protein secretionGO:000930610.014
Mouse
negative regulation of biological processGO:00485193040.014
Human
peptidyl serine modificationGO:001820920.014
peptide transportGO:001583310.014
positive regulation of blood circulationGO:190352420.014
ion transportGO:00068111140.013
response to biotic stimulusGO:0009607970.013
defense responseGO:0006952470.013
regulation of circadian rhythmGO:004275240.013
chloride transmembrane transportGO:190247640.013
regulation of gtpase activityGO:004308720.013
cell cycle arrestGO:000705010.013
nucleic acid metabolic processGO:00903042440.013
central nervous system developmentGO:00074173870.013
rna biosynthetic processGO:00327741810.013
erk1 and erk2 cascadeGO:007037140.013
regulation of blood vessel sizeGO:005088020.013
establishment of localizationGO:00512342440.013
Human Mouse
heterocycle biosynthetic processGO:00181302150.013
cellular component assemblyGO:00226071700.013
Human Mouse
regulation of protein complex disassemblyGO:004324410.013
Human Mouse
positive regulation of cytokine productionGO:000181920.013
embryo development ending in birth or egg hatchingGO:00097922710.013
synaptic vesicle endocytosisGO:004848810.013
positive regulation of secretionGO:005104710.013
regulation of proteolysis involved in cellular protein catabolic processGO:190305010.013
response to corticosteroidGO:003196010.013
synaptic vesicle recyclingGO:003646510.013
pole plasm assemblyGO:000731540.013
striated muscle tissue developmentGO:00147061100.013
striated muscle cell developmentGO:00550021080.013
localization of cellGO:00516742440.013
negative regulation of protein complex assemblyGO:003133310.013
developmental growthGO:00485891660.013
head developmentGO:00603223030.013
positive regulation of peptidyl tyrosine phosphorylationGO:005073110.012
guanosine containing compound metabolic processGO:190106840.012
cellular protein metabolic processGO:00442671290.012
regulation of nucleoside metabolic processGO:000911820.012
regulation of microtubule cytoskeleton organizationGO:007050730.012
liver developmentGO:0001889960.012
cellular macromolecule biosynthetic processGO:00346452240.012
regulation of dendrite developmentGO:005077330.012
forebrain cell migrationGO:002188510.012
organelle organizationGO:00069962270.012
Human Mouse
negative regulation of protein kinase activityGO:000646940.012
regulation of neurotransmitter transportGO:005158810.012
regulation of nucleic acid templated transcriptionGO:19035062130.012
regulation of erk1 and erk2 cascadeGO:007037240.012
regulation of gtp catabolic processGO:003312420.012
muscle cell differentiationGO:00426921390.012
ion homeostasisGO:0050801410.012
single organism cellular localizationGO:1902580460.012
transmembrane transportGO:00550851200.012
positive regulation of nitrogen compound metabolic processGO:0051173690.012
cytosolic calcium ion transportGO:006040130.012
regulation of phGO:000688530.012
gastrulation with mouth forming secondGO:0001702440.012
organism emergence from protective structureGO:007168440.012
fatty acid biosynthetic processGO:000663340.012
cellular response to biotic stimulusGO:007121630.012
protein depolymerizationGO:005126110.012
Human Mouse
cellular response to organic cyclic compoundGO:0071407380.012
monovalent inorganic cation homeostasisGO:005506790.012
axonogenesisGO:00074091520.012
regulation of blood coagulationGO:003019310.012
Mouse
muscle cell developmentGO:00550011150.012
aromatic compound biosynthetic processGO:00194382170.012
anion transportGO:0006820380.012
glycerophospholipid biosynthetic processGO:004647410.012
muscle organ developmentGO:00075171010.012
positive regulation of protein complex assemblyGO:003133420.012
Mouse
regulation of cell projection assemblyGO:006049140.011
cellular response to lipopolysaccharideGO:007122230.011
response to external biotic stimulusGO:0043207970.011
regulation of autophagyGO:001050630.011
atp catabolic processGO:000620040.011
negative regulation of multicellular organismal processGO:0051241690.011
oxidation reduction processGO:0055114410.011
negative regulation of mapk cascadeGO:004340940.011
cell adhesionGO:0007155400.011
Human Mouse
negative regulation of cellular catabolic processGO:003133030.011
apoptotic processGO:00069151160.011
organelle assemblyGO:00709251100.011
positive regulation of secretion by cellGO:190353210.011
g1 s transition of mitotic cell cycleGO:000008210.011
positive regulation of cellular component biogenesisGO:004408930.011
Human Mouse
protein stabilizationGO:005082120.011
negative regulation of metabolic processGO:0009892860.011
Human
cellular component biogenesisGO:00440851780.011
Human Mouse
alternative mrna splicing via spliceosomeGO:000038010.011
multicellular organismal macromolecule metabolic processGO:004425920.011
regulation of cellular component organizationGO:0051128860.011
Human Mouse
response to hexoseGO:000974630.011
regulation of exocytosisGO:001715710.011
regulation of sequestering of calcium ionGO:005128240.011
posterior lateral line developmentGO:0048916380.011
negative regulation of cellular processGO:00485232830.011
Human
regulation of growth rateGO:004000910.011
positive regulation of jnk cascadeGO:004633030.011
regulation of inflammatory responseGO:005072720.011
purine ribonucleoside monophosphate catabolic processGO:000916940.011
blood coagulationGO:0007596120.011
Human Mouse
internal protein amino acid acetylationGO:000647520.011
regulation of localizationGO:00328791040.011
response to xenobiotic stimulusGO:0009410450.011
response to glucocorticoidGO:005138410.011
purine nucleoside monophosphate catabolic processGO:000912840.011
response to endogenous stimulusGO:0009719830.011
mononuclear cell proliferationGO:003294310.010
cellular response to molecule of bacterial originGO:007121930.010
neuron projection developmentGO:00311751800.010
calcium ion transport into cytosolGO:006040230.010
locomotionGO:00400113130.010
hatchingGO:003518840.010
single fertilizationGO:000733830.010
ribonucleoside monophosphate catabolic processGO:000915840.010
intracellular mrna localizationGO:000829810.010
bone remodelingGO:004684920.010
protein targeting to membraneGO:000661210.010
dicarboxylic acid transportGO:000683510.010
phosphorus metabolic processGO:00067931090.010
Human
wound healingGO:0042060900.010
Human Mouse
retina development in camera type eyeGO:00600411460.010
meiotic nuclear divisionGO:000712640.010
rhombomere 5 developmentGO:002157140.010

plek disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.123
immune system diseaseDOID:291400.045
nervous system diseaseDOID:86300.033
cancerDOID:16200.027
disease of cellular proliferationDOID:1456600.027
organ system cancerDOID:005068600.020
primary immunodeficiency diseaseDOID:61200.016
eye and adnexa diseaseDOID:149200.012
eye diseaseDOID:561400.012
sensory system diseaseDOID:005015500.012
disease of metabolismDOID:001466700.011