Danio rerio

97 known processes

fzd2

frizzled homolog 2

(Aliases: zfz2,fz8,cb383,wu:fb70g09,zg08)

fzd2 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
digestive tract morphogenesisGO:00485462310.785
convergent extensionGO:00600261180.524
digestive tract developmentGO:00485652650.516
extracellular structure organizationGO:0043062270.397
blood vessel developmentGO:00015682460.368
response to chemicalGO:00422213200.336
Rat
gastrulationGO:00073692080.292
morphogenesis of an epitheliumGO:00020093330.287
vasculature developmentGO:00019442780.283
negative regulation of response to stimulusGO:00485851040.268
Zebrafish
digestive system developmentGO:00551232890.261
cilium morphogenesisGO:0060271850.259
cell projection morphogenesisGO:00488582440.250
cell motilityGO:00488702440.219
neuron developmentGO:00486662620.200
Mouse
blood vessel morphogenesisGO:00485142160.198
response to nutrientGO:000758430.189
Rat
connective tissue developmentGO:0061448990.188
cognitionGO:005089010.183
multicellular organismal macromolecule metabolic processGO:004425920.181
ameboidal type cell migrationGO:00016671430.172
convergent extension involved in gastrulationGO:0060027710.171
response to stressGO:00069502630.169
cell projection organizationGO:00300302840.156
fat soluble vitamin metabolic processGO:000677540.153
cell morphogenesis involved in differentiationGO:00009041950.153
regulation of erk1 and erk2 cascadeGO:007037240.149
tube morphogenesisGO:00352393490.144
regulation of cell differentiationGO:00455951420.142
heart developmentGO:00075073130.132
multicellular organismal metabolic processGO:004423620.128
angiogenesisGO:00015251580.127
regenerationGO:0031099910.126
single organism metabolic processGO:00447102170.124
positive regulation of erk1 and erk2 cascadeGO:007037420.119
organic substance biosynthetic processGO:19015762890.114
negative regulation of multicellular organismal processGO:0051241690.113
regulation of cellular component organizationGO:0051128860.113
cellular component morphogenesisGO:00329893360.113
neuron projection guidanceGO:0097485860.109
regulation of cellular component movementGO:0051270550.106
regulation of cellular amine metabolic processGO:003323800.105
axon regenerationGO:0031103140.105
cartilage condensationGO:000150230.102
system processGO:00030081850.102
Mouse
cell migration involved in gastrulationGO:0042074790.102
anterior posterior pattern specificationGO:00099521520.101
adherens junction organizationGO:003433240.100
hematopoietic or lymphoid organ developmentGO:00485341910.099
bleb assemblyGO:003206010.099
cilium assemblyGO:0042384580.097
defense responseGO:0006952470.094
localization of cellGO:00516742440.090
regulation of multicellular organismal developmentGO:20000262230.089
Mouse
cellular protein catabolic processGO:004425740.088
erk1 and erk2 cascadeGO:007037140.087
embryo development ending in birth or egg hatchingGO:00097922710.085
Mouse
muscle structure developmentGO:00610611960.084
Mouse
proteolysis involved in cellular protein catabolic processGO:005160330.083
chemosensory behaviorGO:000763510.082
organic cyclic compound biosynthetic processGO:19013622230.081
cellular amine metabolic processGO:004410620.081
positive regulation of cell adhesionGO:004578510.081
negative regulation of developmental growthGO:004864090.080
formation of primary germ layerGO:0001704620.080
cell substrate adhesionGO:003158940.080
nucleocytoplasmic transportGO:000691340.078
muscle cell developmentGO:00550011150.077
muscle tissue developmentGO:00605371100.074
eye developmentGO:00016542770.074
Zebrafish
regulation of synapse organizationGO:005080730.074
negative regulation of signalingGO:0023057960.073
Zebrafish
regulation of bindingGO:005109830.070
regulation of response to stimulusGO:00485832690.070
Zebrafish
cell adhesionGO:0007155400.070
cilium organizationGO:0044782710.069
skeletal system developmentGO:00015011810.068
taxisGO:00423301090.068
endodermal cell differentiationGO:0035987190.067
response to biotic stimulusGO:0009607970.067
collagen metabolic processGO:003296320.067
cartilage developmentGO:0051216960.067
regulation of hormone secretionGO:004688320.066
cellular amino acid metabolic processGO:000652070.066
generation of neuronsGO:00486993850.065
Zebrafish Mouse
cell projection assemblyGO:0030031640.065
endocardial cushion formationGO:000327220.065
striated muscle cell developmentGO:00550021080.064
cell part morphogenesisGO:00329902460.064
sensory organ developmentGO:00074233930.064
Zebrafish Mouse
radial glial cell differentiationGO:006001920.064
Zebrafish
cellular protein modification processGO:00064641000.063
regulation of protein bindingGO:004339330.062
mesenchyme developmentGO:00604851270.062
cardiac cell developmentGO:0055006210.058
chondrocyte developmentGO:000206340.057
regulation of innate immune responseGO:0045088110.057
neuron projection regenerationGO:0031102160.057
amine metabolic processGO:000930820.057
carboxylic acid metabolic processGO:0019752220.057
neurological system processGO:0050877620.056
Mouse
hepaticobiliary system developmentGO:0061008980.056
Zebrafish
muscle organ developmentGO:00075171010.054
Mouse
positive regulation of transportGO:005105020.053
osteoclast differentiationGO:003031610.052
axon developmentGO:00615641660.052
positive regulation of defense responseGO:003134990.052
regulation of epithelial cell proliferationGO:005067830.051
developmental growthGO:00485891660.051
cell migrationGO:00164772370.050
canonical wnt signaling pathwayGO:0060070480.050
Zebrafish
sensory perceptionGO:0007600390.050
Mouse
locomotionGO:00400113130.049
stem cell divisionGO:001714510.049
cellular response to chemical stimulusGO:00708871570.049
Rat
response to corticosteroidGO:003196010.048
notochord developmentGO:0030903540.048
regulation of stem cell proliferationGO:007209120.048
gland developmentGO:00487321430.047
Zebrafish
ubiquitin dependent protein catabolic processGO:000651130.047
oocyte axis specificationGO:000730950.047
regulation of cellular amino acid metabolic processGO:000652100.046
regulation of cell developmentGO:00602841000.046
apoptotic processGO:00069151160.046
cell cell junction organizationGO:0045216100.046
epithelial tube morphogenesisGO:00605621480.046
negative regulation of myeloid cell differentiationGO:004563810.046
cell morphogenesisGO:00009022890.046
extrinsic apoptotic signaling pathwayGO:009719130.045
stem cell proliferationGO:007208940.045
epithelium migrationGO:0090132250.045
protein metabolic processGO:00195381830.044
proteasome mediated ubiquitin dependent protein catabolic processGO:004316120.044
regulation of inflammatory responseGO:005072720.044
multicellular organismal signalingGO:0035637220.043
regulation of cell activationGO:005086510.043
negative regulation of signal transductionGO:0009968940.043
Zebrafish
cellular response to nutrient levelsGO:003166920.043
Rat
regulation of cell migrationGO:0030334400.042
cell surface receptor signaling pathwayGO:00071663250.042
negative regulation of protein phosphorylationGO:000193340.041
modification dependent macromolecule catabolic processGO:004363230.040
response to mercury ionGO:004668910.040
positive regulation of stem cell proliferationGO:200064810.040
single organism cell adhesionGO:0098602290.040
negative regulation of cell communicationGO:0010648960.040
Zebrafish
response to external stimulusGO:00096052640.039
Rat
positive regulation of protein deacetylationGO:009031210.039
regulation of signal transductionGO:00099662250.039
Zebrafish
cellular ketone metabolic processGO:0042180110.039
regulation of nervous system developmentGO:0051960900.038
Mouse
protein localization to plasma membraneGO:007265910.038
regulation of developmental processGO:00507932470.038
Mouse
proteolysisGO:0006508380.038
sensory perception of light stimulusGO:0050953190.037
germ line stem cell maintenanceGO:003071820.037
fat soluble vitamin biosynthetic processGO:004236220.037
single fertilizationGO:000733830.037
immune responseGO:0006955280.037
spermatid developmentGO:000728620.037
single organismal cell cell adhesionGO:0016337290.037
regulation of chondrocyte differentiationGO:003233010.036
cellular component biogenesisGO:00440851780.036
transmembrane receptor protein serine threonine kinase signaling pathwayGO:0007178680.036
cell fate commitmentGO:0045165990.036
Zebrafish
endodermal cell fate commitmentGO:0001711180.036
cell growthGO:0016049570.036
multi organism processGO:00517041340.035
regulation of cytoplasmic transportGO:190364940.035
immune system processGO:00023762410.035
negative regulation of epithelial cell proliferationGO:005068010.035
phosphorylationGO:0016310690.035
rna biosynthetic processGO:00327741810.035
biological adhesionGO:0022610400.034
endoderm developmentGO:0007492490.034
cellular response to lipopolysaccharideGO:007122230.034
somite developmentGO:0061053960.034
rna localizationGO:000640340.034
response to woundingGO:00096111160.034
negative regulation of cell differentiationGO:0045596460.034
phagocytosisGO:000690930.033
epithelial cell morphogenesisGO:000338220.033
regulation of peptidyl tyrosine phosphorylationGO:005073010.033
mesenchymal cell proliferationGO:001046310.033
epithelial to mesenchymal transitionGO:0001837210.032
tight junction assemblyGO:007083010.032
oxidoreduction coenzyme metabolic processGO:000673310.032
protein targeting to nucleusGO:004474430.031
stem cell maintenanceGO:001982740.031
endoderm formationGO:0001706290.031
segmentationGO:0035282970.031
cell junction organizationGO:0034330110.031
growthGO:00400071740.030
neuron projection developmentGO:00311751800.030
positive regulation of stress activated mapk cascadeGO:003287430.030
positive regulation of chromatin modificationGO:190331010.030
positive regulation of cell activationGO:005086710.030
protein modification processGO:00362111000.030
gliogenesisGO:0042063450.030
Zebrafish
regulation of biological qualityGO:00650082630.030
Rat
transcription from rna polymerase iii promoterGO:000638310.029
negative regulation of developmental processGO:0051093650.029
regulation of cellular ketone metabolic processGO:001056570.029
response to glucocorticoidGO:005138410.029
regulation of establishment of protein localizationGO:007020140.029
extracellular matrix organizationGO:0030198270.029
regulation of synapse assemblyGO:005196330.028
regulation of cell motilityGO:2000145460.028
regionalizationGO:00030022740.028
Zebrafish
positive regulation of wound healingGO:009030310.028
epithelial cell migrationGO:0010631250.028
detection of abiotic stimulusGO:0009582240.028
organonitrogen compound metabolic processGO:1901564740.028
regulation of transcription from rna polymerase iii promoterGO:000635910.028
regulation of wnt signaling pathwayGO:0030111530.028
Zebrafish
hemopoiesisGO:00300971830.028
macromolecule modificationGO:00434121110.027
mesenchymal cell developmentGO:0014031780.027
regulation of proteolysisGO:0030162240.027
regulation of canonical wnt signaling pathwayGO:0060828340.026
Zebrafish
positive regulation of chromosome organizationGO:200125210.026
ceramide biosynthetic processGO:004651310.026
lens fiber cell morphogenesisGO:007030930.026
negative regulation of intracellular transportGO:003238730.026
positive regulation of blood circulationGO:190352420.026
regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:200123910.026
response to vitaminGO:003327330.026
Rat
cell morphogenesis involved in neuron differentiationGO:00486671630.026
positive regulation of cellular processGO:00485222010.025
nuclear importGO:005117030.025
formation of anatomical boundaryGO:0048859140.025
positive regulation of cellular amine metabolic processGO:003324000.025
positive regulation of developmental processGO:0051094500.025
chemotaxisGO:00069351040.025
optic placode formation involved in camera type eye formationGO:004661930.025
Zebrafish
positive regulation of cell differentiationGO:0045597300.025
vitamin biosynthetic processGO:000911020.024
defense response to fungusGO:005083220.024
heart processGO:0003015710.024
regulation of chemotaxisGO:0050920180.024
positive regulation of innate immune responseGO:004508980.024
larval developmentGO:000216420.024
regulation of organ growthGO:004662030.023
negative regulation of protein kinase activityGO:000646940.023
regulation of response to stressGO:0080134360.023
regulation of histone deacetylationGO:003106320.023
peptidyl serine phosphorylationGO:001810510.023
regulation of extrinsic apoptotic signaling pathwayGO:200123630.023
axon extensionGO:0048675450.023
cellular component movementGO:00069283350.023
oocyte differentiationGO:0009994140.023
cardiac atrium morphogenesisGO:000320920.022
cell substrate junction assemblyGO:000704420.022
skeletal muscle organ developmentGO:0060538780.022
positive regulation of protein kinase b signalingGO:005189710.022
regulation of intracellular signal transductionGO:1902531570.022
positive regulation of histone modificationGO:003105810.022
cell chemotaxisGO:0060326170.022
compound eye developmentGO:004874920.022
negative regulation of cellular component organizationGO:0051129160.022
regulation of natural killer cell mediated immunityGO:000271510.021
multicellular organism growthGO:003526440.021
lipid storageGO:001991510.021
establishment of localizationGO:00512342440.021
response to organic cyclic compoundGO:0014070510.021
Rat
regulation of cell communicationGO:00106462320.021
Zebrafish
regulation of protein import into nucleusGO:004230620.021
chordate embryonic developmentGO:00430092710.021
Mouse
head developmentGO:00603223030.021
Zebrafish
negative regulation of leukocyte differentiationGO:190210610.021
regulation of receptor mediated endocytosisGO:004825940.020
glial cell migrationGO:000834730.020
regulation of localizationGO:00328791040.020
transmission of nerve impulseGO:0019226190.020
sprouting angiogenesisGO:0002040530.020
modification dependent protein catabolic processGO:001994130.020
peptide transportGO:001583310.020
regulation of locomotionGO:0040012550.020
cell surface receptor signaling pathway involved in heart developmentGO:0061311200.020
positive regulation of cellular amino acid metabolic processGO:004576400.020
regulation of neurogenesisGO:0050767870.020
cell adhesion mediated by integrinGO:003362710.020
response to growth factorGO:0070848390.020
Rat
regulation of blood vessel sizeGO:005088020.019
neuron projection morphogenesisGO:00488121610.019
regulation of growthGO:0040008420.019
establishment of protein localization to organelleGO:007259440.019
negative regulation of reproductive processGO:200024230.019
axonogenesisGO:00074091520.019
regulation of catenin import into nucleusGO:003541220.019
establishment of protein localization to plasma membraneGO:009000210.019
regulation of intracellular protein transportGO:003315730.019
regulation of developmental growthGO:0048638380.019
negative regulation of response to dna damage stimulusGO:200102130.019
regulation of organelle organizationGO:0033043290.018
lymph vessel developmentGO:0001945270.018
basement membrane organizationGO:007171150.018
regulation of cell projection assemblyGO:006049140.018
positive regulation of neuron projection developmentGO:001097690.018
regulation of protein transportGO:005122330.018
regulation of mapk cascadeGO:0043408140.018
craniofacial suture morphogenesisGO:009709420.018
response to decreased oxygen levelsGO:0036293250.018
regulation of establishment of planar polarityGO:009017540.018
Mouse
negative regulation of dna replicationGO:000815620.018
cell fate commitment involved in formation of primary germ layerGO:0060795260.018
embryonic skeletal system developmentGO:0048706970.018
regulation of cell projection organizationGO:0031344440.018
branching morphogenesis of a nerveGO:004875540.018
optic placode formationGO:000174340.018
Zebrafish
regulation of cell substrate adhesionGO:001081010.017
intramembranous ossificationGO:000195730.017
developmental cell growthGO:0048588520.017
organelle organizationGO:00069962270.017
regulation of nitrogen compound metabolic processGO:00511712510.017
regulation of cell growthGO:0001558290.017
cellular component assembly involved in morphogenesisGO:00109271070.017
innate immune responseGO:0045087130.017
spinal cord radial glial cell differentiationGO:002153120.017
Zebrafish
negative regulation of chemotaxisGO:005092240.017
axon guidanceGO:0007411860.017
cellular response to lipidGO:0071396390.017
Rat
positive regulation of neurogenesisGO:0050769240.017
cellular component assemblyGO:00226071700.017
innate immune response activating signal transductionGO:000275850.016
positive regulation of epithelial cell proliferationGO:005067910.016
proteasomal protein catabolic processGO:001049820.016
neuron differentiationGO:00301823530.016
Zebrafish Mouse
visual perceptionGO:0007601170.016
appendage morphogenesisGO:0035107560.016
regulation of neuron projection developmentGO:0010975400.016
apical junction assemblyGO:004329710.016
cellular macromolecule metabolic processGO:00442603910.016
dorsal ventral pattern formationGO:00099531250.016
Zebrafish
heart morphogenesisGO:00030071560.016
kidney developmentGO:0001822920.016
regulation of reproductive processGO:200024140.016
behaviorGO:0007610740.016
oxoacid metabolic processGO:0043436310.016
oocyte developmentGO:0048599140.016
heterocycle metabolic processGO:00464832900.016
organic acid metabolic processGO:0006082310.016
regulation of protein localization to nucleusGO:190018020.016
positive regulation of mesoderm developmentGO:200038210.016
multicellular organismal reproductive processGO:0048609350.016
muscle cell differentiationGO:00426921390.016
positive regulation of histone deacetylationGO:003106510.016
negative regulation of sequence specific dna binding transcription factor activityGO:004343320.016
mesenchymal cell differentiationGO:0048762870.015
regulation of cellular component sizeGO:0032535300.015
positive regulation of biological processGO:00485182530.015
embryonic organ developmentGO:00485683810.015
regulation of cellular protein metabolic processGO:0032268520.015
lateral inhibitionGO:004633110.015
ras protein signal transductionGO:000726570.015
carbohydrate homeostasisGO:003350010.015
regulation of stem cell differentiationGO:200073640.015
cell recognitionGO:0008037190.015
positive regulation of chronic inflammatory responseGO:000267810.015
endocardial cushion morphogenesisGO:000320330.015
response to monosaccharideGO:003428430.015
response to drugGO:004249330.015
rna metabolic processGO:00160702190.015
protein import into nucleusGO:000660630.015
cell cycle g1 s phase transitionGO:004484310.015
agingGO:000756820.014
negative regulation of signal transduction by p53 class mediatorGO:190179780.014
retina layer formationGO:0010842240.014
positive regulation of locomotionGO:0040017140.014
lamellipodium assemblyGO:003003210.014
rho protein signal transductionGO:000726650.014
single organism behaviorGO:0044708240.014
regulation of cell shapeGO:000836010.014
cell aggregationGO:009874330.014
small gtpase mediated signal transductionGO:000726480.014
catenin import into nucleusGO:003541120.014
regulation of mesenchymal cell proliferationGO:001046410.014
regulation of multicellular organism growthGO:004001440.014
immune system developmentGO:00025201910.014
peptidyl serine modificationGO:001820920.013
response to other organismGO:0051707970.013
hindbrain developmentGO:0030902910.013
Zebrafish
endothelial cell migrationGO:0043542190.013
neuronal action potentialGO:0019228180.013
negative regulation of wnt signaling pathwayGO:0030178300.013
Zebrafish
oocyte constructionGO:000730850.013
appendage developmentGO:0048736800.013
transportGO:00068102200.013
regulation of metal ion transportGO:001095940.013
negative regulation of protein import into nucleusGO:004230820.013
cardiac muscle tissue developmentGO:0048738480.013
regulation of organ morphogenesisGO:2000027350.013
Mouse
post embryonic organ developmentGO:004856940.013
convergent extension involved in axis elongationGO:0060028260.013
cell deathGO:00082191210.013
liver developmentGO:0001889960.013
Zebrafish
bone remodelingGO:004684920.013
endothelial cell morphogenesisGO:000188610.013
response to abiotic stimulusGO:00096281220.013
deathGO:00162651210.013
regulation of dendrite developmentGO:005077330.013
heterocycle biosynthetic processGO:00181302150.013
cellular response to organic substanceGO:00713101050.013
Rat
negative regulation of cellular processGO:00485232830.013
Zebrafish
negative regulation of growthGO:0045926100.013
nuclear transportGO:005116940.012
regulation of primary metabolic processGO:00800903110.012
cardiac atrium developmentGO:000323040.012
organelle assemblyGO:00709251100.012
smoothened signaling pathwayGO:0007224300.012
negative regulation of extrinsic apoptotic signaling pathwayGO:200123720.012
synaptic growth at neuromuscular junctionGO:005112420.012
positive regulation of secretion by cellGO:190353210.012
negative regulation of molecular functionGO:0044092230.012
negative regulation of small gtpase mediated signal transductionGO:005105810.012
regulation of cell deathGO:00109411030.012
neuroblast proliferationGO:000740520.012
skeletal system morphogenesisGO:00487051020.012
detection of external stimulusGO:0009581240.012
tissue remodelingGO:004877140.012
melanin metabolic processGO:000658220.012
regulation of nucleocytoplasmic transportGO:004682220.012
maintenance of locationGO:005123540.012
proepicardium developmentGO:000334240.012
positive regulation of stress activated protein kinase signaling cascadeGO:007030430.012
response to organic substanceGO:00100331530.012
Rat
axonal defasciculationGO:000741420.012
embryonic cranial skeleton morphogenesisGO:0048701900.012
negative regulation of behaviorGO:004852160.012
medial fin developmentGO:0033338160.012
single organism reproductive processGO:0044702400.012
striated muscle tissue developmentGO:00147061100.012
regulation of dna damage response signal transduction by p53 class mediatorGO:004351640.012
regulation of membrane potentialGO:0042391230.012
pericardium morphogenesisGO:000334410.012
positive regulation of map kinase activityGO:004340630.012
protein deacetylationGO:000647630.012
response to fungusGO:0009620250.012
regulation of neuron differentiationGO:0045664560.011
negative regulation of multi organism processGO:004390130.011
somitogenesisGO:0001756870.011
response to steroid hormoneGO:0048545350.011
positive regulation of mesenchymal cell proliferationGO:000205310.011
negative regulation of endodermal cell differentiationGO:190322580.011
eye morphogenesisGO:00485921440.011
Zebrafish
response to external biotic stimulusGO:0043207970.011
regulation of rna metabolic processGO:00512522240.011
negative regulation of metabolic processGO:0009892860.011
negative regulation of cytokine productionGO:000181810.011
regulation of protein modification processGO:0031399290.011
protein importGO:001703830.011
peptidyl amino acid modificationGO:0018193160.011
regulation of wnt signaling pathway planar cell polarity pathwayGO:200009520.011
cellular response to biotic stimulusGO:007121630.011
renal system vasculature developmentGO:006143720.011
positive regulation of peptidyl tyrosine phosphorylationGO:005073110.011
phosphate containing compound metabolic processGO:00067961080.011
striated muscle cell differentiationGO:00511461290.011
lens fiber cell developmentGO:007030730.011
enzyme linked receptor protein signaling pathwayGO:00071671060.011
regulation of metabolic processGO:00192223590.011
negative regulation of chromosome organizationGO:200125110.011
regulation of dna replicationGO:000627530.011
positive regulation of secretionGO:005104710.011
hormone secretionGO:004687920.011
epithelial cell developmentGO:0002064420.011
regulation of behaviorGO:0050795240.011
regulation of epithelial to mesenchymal transitionGO:001071730.011
modification of morphology or physiology of other organismGO:003582140.011
regulation of protein targetingGO:190353320.011
single organism nuclear importGO:190259330.011
embryonic heart tube morphogenesisGO:00031431080.011
septum transversum developmentGO:000334340.011
secondary metabolic processGO:001974830.011
neural crest cell developmentGO:0014032620.011
heart joggingGO:0003146400.011
regulation of rho protein signal transductionGO:003502320.011
regulation of protein kinase b signalingGO:005189680.010

fzd2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.212
developmental disorder of mental healthDOID:006003700.030
disease of mental healthDOID:15000.030
vascular diseaseDOID:17800.025
artery diseaseDOID:005082800.025
cardiovascular system diseaseDOID:128700.025
disease of cellular proliferationDOID:1456600.018
nervous system diseaseDOID:86300.018
gastrointestinal system cancerDOID:311900.015
cancerDOID:16200.015
organ system cancerDOID:005068600.015
bone development diseaseDOID:008000600.014
bone diseaseDOID:008000100.014
musculoskeletal system diseaseDOID:1700.014
osteochondrodysplasiaDOID:225600.014
connective tissue diseaseDOID:6500.014
disease of metabolismDOID:001466700.013