Danio rerio

0 known processes

pcsk2

proprotein convertase subtilisin/kexin type 2

pcsk2 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
peptide metabolic processGO:000651810.698
Mouse Worm Fly
cartilage morphogenesisGO:0060536130.694
Zebrafish
mechanosensory lateral line system developmentGO:0048881490.583
Zebrafish
cellular amide metabolic processGO:004360340.470
Mouse Worm Fly
neuromast developmentGO:0048884460.455
Zebrafish
sensory organ developmentGO:00074233930.442
Zebrafish
embryonic organ developmentGO:00485683810.440
Zebrafish
embryo development ending in birth or egg hatchingGO:00097922710.342
Zebrafish
steroid hormone mediated signaling pathwayGO:004340190.307
lateral line system developmentGO:0048925760.298
Zebrafish
lateral line developmentGO:0048882660.293
Zebrafish
embryonic skeletal system developmentGO:0048706970.259
Zebrafish
long chain fatty acid metabolic processGO:000167610.223
amide biosynthetic processGO:004360410.223
signal transductionGO:00071654550.217
locomotionGO:00400113130.210
Worm
cellular nitrogen compound metabolic processGO:00346412900.204
Mouse Worm Fly
embryonic skeletal system morphogenesisGO:0048704930.201
Zebrafish
agingGO:000756820.200
Worm
inner ear developmentGO:00488391260.190
regulation of gene expressionGO:00104682650.186
cellular nitrogen compound biosynthetic processGO:00442712180.173
connective tissue developmentGO:0061448990.172
Zebrafish
negative regulation of biological processGO:00485193040.172
Worm
anterior lateral line developmentGO:004889950.171
Zebrafish
innate immune responseGO:0045087130.159
nik nf kappab signalingGO:003806110.159
nucleobase containing compound metabolic processGO:00061392740.152
embryonic organ morphogenesisGO:00485622740.146
Zebrafish
embryonic viscerocranium morphogenesisGO:0048703520.144
Zebrafish
cellular biosynthetic processGO:00442492860.144
sensory system developmentGO:0048880760.143
Zebrafish
protein processingGO:0016485120.134
Mouse Worm Fly
anterior lateral line system developmentGO:004889890.130
Zebrafish
organic substance biosynthetic processGO:19015762890.129
biosynthetic processGO:00090582940.125
appendage morphogenesisGO:0035107560.119
Zebrafish
regulation of biological qualityGO:00650082630.114
Mouse Worm Fly
oxidation reduction processGO:0055114410.113
regulation of defense responseGO:0031347140.106
synaptic target recognitionGO:000803910.100
chordate embryonic developmentGO:00430092710.099
Zebrafish
larval developmentGO:000216420.099
very long chain fatty acid biosynthetic processGO:004276140.097
determination of left right symmetryGO:00073681790.093
nucleobase containing compound biosynthetic processGO:00346542050.092
heterocycle biosynthetic processGO:00181302150.087
cellular macromolecule metabolic processGO:00442603910.085
fin developmentGO:0033333770.082
Zebrafish
nitrogen compound metabolic processGO:00068073190.082
Mouse Worm Fly
cartilage developmentGO:0051216960.081
Zebrafish
positive regulation of transportGO:005105020.078
nucleic acid metabolic processGO:00903042440.076
regulation of cellular biosynthetic processGO:00313262450.075
central nervous system developmentGO:00074173870.073
programmed cell deathGO:00125011190.071
protein metabolic processGO:00195381830.070
Mouse Worm Fly
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domainsGO:000246040.070
rna biosynthetic processGO:00327741810.069
heart developmentGO:00075073130.069
regulation of cellular metabolic processGO:00313233200.069
gene expressionGO:00104672520.066
Mouse Worm Fly
negative regulation of nucleic acid templated transcriptionGO:1903507450.066
negative regulation of cellular processGO:00485232830.066
regulation of establishment of protein localizationGO:007020140.064
humoral immune response mediated by circulating immunoglobulinGO:000245530.060
fatty acid biosynthetic processGO:000663340.060
regulation of rna metabolic processGO:00512522240.059
response to biotic stimulusGO:0009607970.059
determination of bilateral symmetryGO:00098552040.058
multi organism processGO:00517041340.056
Worm
regulation of glucose importGO:004632410.056
membrane invaginationGO:001032410.053
response to oxidative stressGO:0006979110.053
maintenance of locationGO:005123540.053
regulation of apoptotic processGO:0042981980.052
regulation of metabolic processGO:00192223590.051
response to external stimulusGO:00096052640.051
response to drugGO:004249330.050
regulation of nucleobase containing compound metabolic processGO:00192192500.050
regulation of hormone levelsGO:0010817210.050
Mouse Worm Fly
positive regulation of leukocyte mediated cytotoxicityGO:000191210.050
pericardium morphogenesisGO:000334410.049
localization of cellGO:00516742440.048
cell surface receptor signaling pathwayGO:00071663250.048
regulation of reproductive processGO:200024140.047
Worm
appendage developmentGO:0048736800.046
Zebrafish
regulation of protein transportGO:005122330.045
multi organism cellular processGO:004476420.045
brain developmentGO:00074202930.044
regulation of cyclin dependent protein serine threonine kinase activityGO:000007910.044
phosphorus metabolic processGO:00067931090.044
cell motilityGO:00488702440.044
regulation of cytoplasmic transportGO:190364940.043
nucleic acid templated transcriptionGO:00976591810.043
establishment of localizationGO:00512342440.043
organic cyclic compound biosynthetic processGO:19013622230.041
regulation of macromolecule biosynthetic processGO:00105562250.041
regulation of rna biosynthetic processGO:20011412130.041
regulation of protein localization to nucleusGO:190018020.041
response to topologically incorrect proteinGO:003596620.041
hematopoietic stem cell differentiationGO:0060218200.041
regulation of cellular macromolecule biosynthetic processGO:20001122220.041
cellular localizationGO:0051641970.041
negative regulation of macromolecule metabolic processGO:0010605760.040
female sex differentiationGO:004666040.040
regulation of transcription dna templatedGO:00063552130.039
fatty acid elongationGO:003049710.039
hormone transportGO:000991420.038
cellular protein metabolic processGO:00442671290.038
rna metabolic processGO:00160702190.038
protein maturationGO:0051604120.038
Mouse Worm Fly
transportGO:00068102200.038
regulation of nucleocytoplasmic transportGO:004682220.037
long chain fatty acid biosynthetic processGO:004275910.037
cell deathGO:00082191210.037
phagocytosisGO:000690930.036
response to stressGO:00069502630.036
cellular macromolecule biosynthetic processGO:00346452240.036
regulation of cell communicationGO:00106462320.036
regulation of stem cell differentiationGO:200073640.036
cell recognitionGO:0008037190.036
homeostatic processGO:00425921420.036
Fly
morphogenesis of an epitheliumGO:00020093330.035
organonitrogen compound biosynthetic processGO:1901566470.035
epithelial cell differentiationGO:00308551160.035
ear developmentGO:00435831270.035
response to monosaccharideGO:003428430.035
lipid storageGO:001991510.034
regulation of multicellular organismal processGO:00512392770.034
Worm
membrane lipid biosynthetic processGO:004646720.034
fin morphogenesisGO:0033334530.034
Zebrafish
negative regulation of gene expressionGO:0010629650.033
regulation of macromolecule metabolic processGO:00602553170.033
transcription from rna polymerase ii promoterGO:0006366800.033
membrane fusionGO:006102520.033
urogenital system developmentGO:0001655970.033
nucleic acid phosphodiester bond hydrolysisGO:009030560.032
regulation of nitrogen compound metabolic processGO:00511712510.032
single organism membrane fusionGO:004480120.032
phosphate containing compound metabolic processGO:00067961080.032
generation of neuronsGO:00486993850.032
aromatic compound biosynthetic processGO:00194382170.032
response to external biotic stimulusGO:0043207970.031
negative regulation of translationGO:001714810.031
hormone metabolic processGO:0042445190.031
Mouse Worm Fly
regulation of protein targetingGO:190353320.031
cellular response to xenobiotic stimulusGO:0071466350.031
detection of stimulusGO:0051606290.030
negative regulation of macromolecule biosynthetic processGO:0010558480.030
response to glucoseGO:000974930.030
regionalizationGO:00030022740.030
regulation of signal transductionGO:00099662250.030
stem cell proliferationGO:007208940.030
single organism localizationGO:19025782250.030
regulation of intracellular protein transportGO:003315730.029
negative regulation of peptidase activityGO:0010466100.029
i kappab kinase nf kappab signalingGO:000724940.028
cellular carbohydrate metabolic processGO:004426240.028
negative regulation of defense responseGO:003134820.028
response to chemicalGO:00422213200.028
organelle fusionGO:004828430.028
system processGO:00030081850.027
glucose importGO:004632320.027
cellular aromatic compound metabolic processGO:00067252950.027
specification of symmetryGO:00097992040.026
cellular component assemblyGO:00226071700.026
endocrine processGO:005088620.026
regulation of protein complex assemblyGO:004325430.025
mitotic cell cycle processGO:1903047480.025
response to other organismGO:0051707970.025
neuron developmentGO:00486662620.025
negative regulation of apoptotic processGO:0043066550.025
negative regulation of reproductive processGO:200024230.025
Worm
interspecies interaction between organismsGO:004441940.025
zymogen activationGO:003163830.025
regulation of nucleic acid templated transcriptionGO:19035062130.025
immunoglobulin mediated immune responseGO:001606430.025
protein secretionGO:000930610.025
symbiosis encompassing mutualism through parasitismGO:004440340.024
regulation of nik nf kappab signalingGO:190122210.024
nuclear importGO:005117030.024
regulation of transcription from rna polymerase ii promoterGO:00063571140.024
regulation of protein bindingGO:004339330.024
positive regulation of immune responseGO:0050778110.024
protein activation cascadeGO:007237660.024
hormone secretionGO:004687920.024
vacuolar transportGO:000703420.024
lipid metabolic processGO:0006629520.023
stem cell maintenanceGO:001982740.023
negative regulation of cellular macromolecule biosynthetic processGO:2000113480.023
regulation of carbohydrate metabolic processGO:000610940.023
regulation of localizationGO:00328791040.023
regulation of protein catabolic processGO:004217610.023
neuron differentiationGO:00301823530.023
cell killingGO:000190620.023
catabolic processGO:0009056320.023
Worm
negative regulation of rna biosynthetic processGO:1902679450.023
transcription dna templatedGO:00063511810.023
positive regulation of cell cycleGO:004578730.023
cellular response to unfolded proteinGO:003462020.023
carboxylic acid metabolic processGO:0019752220.023
nuclear transportGO:005116940.022
regulation of stem cell proliferationGO:007209120.022
regulation of cytokine productionGO:000181730.022
single organism metabolic processGO:00447102170.022
cellular response to stressGO:0033554620.022
negative regulation of protein phosphorylationGO:000193340.022
hematopoietic or lymphoid organ developmentGO:00485341910.022
fatty acid elongation unsaturated fatty acidGO:001936810.021
regulation of programmed cell deathGO:00430671010.021
protein localization to nucleusGO:003450430.021
regulation of symbiosis encompassing mutualism through parasitismGO:004390310.021
er nucleus signaling pathwayGO:000698420.021
smooth muscle contractionGO:000693920.020
positive regulation of cellular metabolic processGO:0031325940.020
response to carbohydrateGO:000974330.020
regulation of i kappab kinase nf kappab signalingGO:004312240.020
regulation of primary metabolic processGO:00800903110.020
organelle organizationGO:00069962270.020
response to hexoseGO:000974630.020
cellular component morphogenesisGO:00329893360.020
b cell activationGO:004211320.020
regulation of cell cycleGO:0051726520.020
positive regulation of stress activated mapk cascadeGO:003287430.020
negative regulation of nitrogen compound metabolic processGO:0051172590.020
regulation of protein import into nucleusGO:004230620.019
protein modification processGO:00362111000.019
heterocycle metabolic processGO:00464832900.019
blood vessel developmentGO:00015682460.019
energy reserve metabolic processGO:000611220.019
positive regulation of cytokine productionGO:000181920.019
phagocytosis engulfmentGO:000691110.019
positive regulation of neuron deathGO:190121610.019
gastrulationGO:00073692080.019
pericardium developmentGO:006003910.019
negative regulation of cellular biosynthetic processGO:0031327550.019
cell proliferationGO:0008283800.019
small molecule metabolic processGO:0044281770.019
regulation of locomotionGO:0040012550.019
Worm
regulation of cardiac muscle contractionGO:005511720.019
very long chain fatty acid metabolic processGO:000003840.019
striated muscle cell differentiationGO:00511461290.018
cytokine mediated signaling pathwayGO:001922170.018
regulation of multicellular organismal developmentGO:20000262230.018
negative regulation of protein kinase activityGO:000646940.018
negative regulation of programmed cell deathGO:0043069580.018
cellular response to external stimulusGO:007149620.018
single organism organelle organizationGO:19025891990.018
regulation of hormone secretionGO:004688320.018
ribosomal small subunit biogenesisGO:004227420.018
meiotic nuclear divisionGO:000712640.018
regulation of bindingGO:005109830.018
ameboidal type cell migrationGO:00016671430.017
protein complex localizationGO:003150310.017
regulation of signalingGO:00230512350.017
nucleocytoplasmic transportGO:000691340.017
plasminogen activationGO:003163930.017
macroautophagyGO:001623610.017
positive regulation of stress activated protein kinase signaling cascadeGO:007030430.017
regulation of immune system processGO:0002682340.017
cellular component movementGO:00069283350.017
regulation of protein metabolic processGO:0051246560.017
negative regulation of cell differentiationGO:0045596460.017
cellular response to organic substanceGO:00713101050.017
microtubule organizing center organizationGO:003102310.017
positive regulation of lymphocyte mediated immunityGO:000270810.017
macromolecule biosynthetic processGO:00090592270.017
response to nutrientGO:000758430.017
regulation of peptidase activityGO:0052547230.016
axon developmentGO:00615641660.016
heart contractionGO:0060047710.016
positive regulation of neural precursor cell proliferationGO:200017910.016
peptide transportGO:001583310.016
negative regulation of hydrolase activityGO:0051346100.016
centrosome organizationGO:005129710.016
establishment of protein localization to organelleGO:007259440.016
negative regulation of cell communicationGO:0010648960.016
negative regulation of nucleobase containing compound metabolic processGO:0045934590.016
single organism transportGO:00447652060.016
positive regulation of cell adhesionGO:004578510.016
regulation of molecular functionGO:0065009700.016
cellular response to molecule of bacterial originGO:007121930.016
complement activationGO:000695630.016
peptidyl serine modificationGO:001820920.016
regulation of cell shapeGO:000836010.015
morphogenesis of an epithelial sheetGO:0002011490.015
cellular component biogenesisGO:00440851780.015
apoptotic processGO:00069151160.015
negative regulation of rna metabolic processGO:0051253480.015
defense responseGO:0006952470.015
regulation of leukocyte mediated cytotoxicityGO:000191010.015
female gonad developmentGO:000858540.015
androgen metabolic processGO:000820920.015
positive regulation of cellular catabolic processGO:003133130.015
antimicrobial humoral responseGO:001973020.015
sensory perception of smellGO:000760820.015
cognitionGO:005089010.015
protein import into nucleusGO:000660630.015
cell migrationGO:00164772370.015
meiosis iGO:000712710.015
deathGO:00162651210.015
golgi vesicle transportGO:004819330.015
regulation of cell proliferationGO:0042127370.015
modification of morphology or physiology of other organismGO:003582140.014
regulation of actin filament based movementGO:190311510.014
meiotic cell cycle processGO:190304630.014
carbohydrate homeostasisGO:003350010.014
Fly
mrna cleavage involved in gene silencing by mirnaGO:003527910.014
carboxylic acid catabolic processGO:004639530.014
embryonic heart tube developmentGO:00350501330.014
response to endogenous stimulusGO:0009719830.014
negative regulation of secretionGO:005104820.014
cellular response to starvationGO:000926710.014
viral processGO:001603210.014
cell part morphogenesisGO:00329902460.014
hemopoiesisGO:00300971830.014
regulation of blood pressureGO:000821710.014
regulation of multicellular organism growthGO:004001440.014
regulation of cell motilityGO:2000145460.014
glucose homeostasisGO:004259310.014
cellular response to topologically incorrect proteinGO:003596720.014
cellular response to biotic stimulusGO:007121630.014
protein targeting to nucleusGO:004474430.014
negative regulation of locomotionGO:0040013180.014
cell cycle g2 m phase transitionGO:004483940.014
organic substance catabolic processGO:1901575280.014
Worm
positive regulation of cell divisionGO:005178120.014
negative regulation of meiotic cell cycleGO:005144710.014
negative regulation of mapk cascadeGO:004340940.013
epithelial tube morphogenesisGO:00605621480.013
single organism nuclear importGO:190259330.013
multicellular organism growthGO:003526440.013
regulation of leukocyte mediated immunityGO:000270310.013
regulation of cellular protein catabolic processGO:190336210.013
purine ribonucleoside biosynthetic processGO:004612920.013
negative regulation of biosynthetic processGO:0009890550.013
lipid digestionGO:004424130.013
response to bacteriumGO:0009617580.013
endoplasmic reticulum unfolded protein responseGO:003096820.013
proteolysisGO:0006508380.013
Mouse Worm Fly
liver developmentGO:0001889960.013
cellular component disassemblyGO:002241110.013
intracellular signal transductionGO:0035556850.013
glial cell proliferationGO:001400940.013
regulation of developmental processGO:00507932470.012
dna catabolic processGO:000630810.012
cellular protein catabolic processGO:004425740.012
myeloid cell differentiationGO:0030099860.012
regulation of muscle contractionGO:000693730.012
sensory perception of painGO:001923310.012
regulation of inflammatory responseGO:005072720.012
regulation of cell deathGO:00109411030.012
regulation of ion transmembrane transporter activityGO:003241220.012
lipid oxidationGO:003444010.012
cell proliferation involved in heart morphogenesisGO:006132320.012
immune system processGO:00023762410.012
response to unfolded proteinGO:000698620.012
negative regulation of signal transductionGO:0009968940.012
cellular response to lipopolysaccharideGO:007122230.012
vasculature developmentGO:00019442780.012
leukocyte mediated cytotoxicityGO:000190910.012
cellular lipid catabolic processGO:004424230.012
modification of morphology or physiology of other organism involved in symbiotic interactionGO:005181740.012
positive regulation of translationGO:004572710.012
regulation of response to stimulusGO:00485832690.012
Worm
positive regulation of cell killingGO:003134320.012
positive regulation of signalingGO:0023056560.012
regulation of system processGO:0044057400.012
anterior posterior pattern specificationGO:00099521520.012
interaction with hostGO:005170140.012
immune system developmentGO:00025201910.012
regulation of lymphocyte mediated immunityGO:000270610.012
regulation of membrane repolarizationGO:006030610.011
posttranscriptional regulation of gene expressionGO:0010608140.011
regulation of intracellular signal transductionGO:1902531570.011
positive regulation of biological processGO:00485182530.011
cellular response to extracellular stimulusGO:003166820.011
regulation of transferase activityGO:0051338160.011
macromolecule modificationGO:00434121110.011
regulation of neural precursor cell proliferationGO:200017730.011
negative regulation of cytokine productionGO:000181810.011
cellular response to light stimulusGO:007148240.011
anion transportGO:0006820380.011
negative regulation of transcription dna templatedGO:0045892450.011
positive regulation of developmental processGO:0051094500.011
gtp metabolic processGO:004603940.011
developmental programmed cell deathGO:001062340.011
phosphorylationGO:0016310690.011
positive regulation of cellular amine metabolic processGO:003324000.011
guanosine containing compound catabolic processGO:190106920.011
positive regulation of biosynthetic processGO:0009891680.011
centrosome cycleGO:000709810.011
muscle system processGO:0003012200.011
negative regulation of multi organism processGO:004390130.011
Worm
muscle cell developmentGO:00550011150.011
regulation of sodium ion transportGO:000202820.011
regulation of cellular component movementGO:0051270550.011
regulation of meiotic cell cycleGO:005144510.011
positive regulation of i kappab kinase nf kappab signalingGO:004312330.011
neurotransmitter secretionGO:000726920.011
adult behaviorGO:003053420.011
regulation of cysteine type endopeptidase activityGO:2000116210.011
pigmentationGO:0043473850.011
regulation of innate immune responseGO:0045088110.010
osteoclast differentiationGO:003031610.010
embryonic heart tube morphogenesisGO:00031431080.010
stem cell differentiationGO:00488631170.010
organelle assemblyGO:00709251100.010
muscle structure developmentGO:00610611960.010
positive regulation of phosphorus metabolic processGO:0010562210.010
sphingolipid biosynthetic processGO:003014820.010
positive regulation of dna metabolic processGO:005105410.010
response to vitamin b3GO:003355220.010
response to alkaloidGO:004327920.010
photoreceptor cell fate specificationGO:004370410.010
transmembrane receptor protein serine threonine kinase signaling pathwayGO:0007178680.010

pcsk2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.025
nervous system diseaseDOID:86300.013
sensory system diseaseDOID:005015500.013
disease of cellular proliferationDOID:1456600.010
cancerDOID:16200.010
organ system cancerDOID:005068600.010