Danio rerio

0 known processes

pcsk1

proprotein convertase subtilisin/kexin type 1

pcsk1 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
peptide metabolic processGO:000651810.664
Mouse
anterior lateral line system developmentGO:004889890.605
Zebrafish
neuromast developmentGO:0048884460.540
Zebrafish
embryonic viscerocranium morphogenesisGO:0048703520.490
Zebrafish
cellular amide metabolic processGO:004360340.446
Mouse
mechanosensory lateral line system developmentGO:0048881490.437
Zebrafish
fin developmentGO:0033333770.420
Zebrafish
embryonic skeletal system morphogenesisGO:0048704930.374
Zebrafish
agingGO:000756820.361
cartilage morphogenesisGO:0060536130.353
Zebrafish
embryonic skeletal system developmentGO:0048706970.340
Zebrafish
hatchingGO:003518840.324
lateral line system developmentGO:0048925760.310
Zebrafish
anterior lateral line developmentGO:004889950.287
Zebrafish
sensory organ developmentGO:00074233930.285
Zebrafish
regulation of biological qualityGO:00650082630.262
Mouse
organism emergence from protective structureGO:007168440.243
negative regulation of reproductive processGO:200024230.242
negative regulation of biological processGO:00485193040.239
appendage developmentGO:0048736800.226
Zebrafish
negative regulation of response to stimulusGO:00485851040.221
cellular macromolecule metabolic processGO:00442603910.219
lateral line developmentGO:0048882660.213
Zebrafish
embryonic organ developmentGO:00485683810.207
Zebrafish
gene expressionGO:00104672520.198
Mouse
connective tissue developmentGO:0061448990.193
Zebrafish
locomotionGO:00400113130.180
hormone metabolic processGO:0042445190.174
Mouse
appendage morphogenesisGO:0035107560.166
Zebrafish
regulation of gene expressionGO:00104682650.162
carbohydrate homeostasisGO:003350010.162
larval behaviorGO:003053750.160
larval locomotory behaviorGO:000834550.158
regulation of reproductive processGO:200024140.158
central nervous system developmentGO:00074173870.156
sensory system developmentGO:0048880760.149
Zebrafish
regulation of multicellular organismal processGO:00512392770.149
negative regulation of multicellular organismal processGO:0051241690.149
glucose importGO:004632320.148
response to external stimulusGO:00096052640.146
cellular nitrogen compound metabolic processGO:00346412900.137
Mouse
innate immune responseGO:0045087130.134
protein metabolic processGO:00195381830.133
Mouse
regulation of response to stimulusGO:00485832690.124
protein processingGO:0016485120.123
Mouse
embryonic organ morphogenesisGO:00485622740.117
Zebrafish
synaptic target recognitionGO:000803910.112
embryo development ending in birth or egg hatchingGO:00097922710.108
Zebrafish
organic substance biosynthetic processGO:19015762890.106
Mouse
cellular biosynthetic processGO:00442492860.099
Mouse
protein maturationGO:0051604120.092
Mouse
response to oxidative stressGO:0006979110.092
inner ear developmentGO:00488391260.090
epithelial cell developmentGO:0002064420.089
regulation of cytokine productionGO:000181730.087
homeostatic processGO:00425921420.086
maintenance of locationGO:005123540.084
multi organism processGO:00517041340.082
response to monosaccharideGO:003428430.082
nucleobase containing compound metabolic processGO:00061392740.081
nucleic acid metabolic processGO:00903042440.077
chemical homeostasisGO:0048878490.077
signal transductionGO:00071654550.076
response to chemicalGO:00422213200.073
negative regulation of cellular processGO:00485232830.071
response to stressGO:00069502630.071
rna metabolic processGO:00160702190.070
cell surface receptor signaling pathwayGO:00071663250.070
nuclear transportGO:005116940.069
establishment of localizationGO:00512342440.066
epithelial cell differentiationGO:00308551160.066
symbiosis encompassing mutualism through parasitismGO:004440340.066
transportGO:00068102200.065
organic anion transportGO:0015711150.063
positive regulation of transportGO:005105020.061
regulation of nucleobase containing compound metabolic processGO:00192192500.061
fin morphogenesisGO:0033334530.059
Zebrafish
ear developmentGO:00435831270.059
multi organism cellular processGO:004476420.059
nitrogen compound metabolic processGO:00068073190.058
Mouse
response to topologically incorrect proteinGO:003596620.058
cartilage developmentGO:0051216960.057
Zebrafish
dicarboxylic acid transportGO:000683510.057
positive regulation of neuron deathGO:190121610.056
regulation of muscle contractionGO:000693730.055
larval developmentGO:000216420.055
regulation of cellular biosynthetic processGO:00313262450.055
cellular component assemblyGO:00226071700.055
chordate embryonic developmentGO:00430092710.054
Zebrafish
response to biotic stimulusGO:0009607970.054
regulation of multicellular organism growthGO:004001440.052
regulation of rna metabolic processGO:00512522240.051
negative regulation of behaviorGO:004852160.050
regulation of hormone levelsGO:0010817210.050
Mouse
positive regulation of leukocyte mediated cytotoxicityGO:000191210.049
negative regulation of defense responseGO:003134820.048
nucleic acid templated transcriptionGO:00976591810.048
negative regulation of gene expressionGO:0010629650.048
regulation of hormone secretionGO:004688320.047
single organism transportGO:00447652060.047
regulation of cytoplasmic transportGO:190364940.047
negative regulation of nucleic acid templated transcriptionGO:1903507450.046
generation of neuronsGO:00486993850.046
determination of bilateral symmetryGO:00098552040.046
hormone transportGO:000991420.045
rna biosynthetic processGO:00327741810.044
hormone mediated signaling pathwayGO:000975590.044
multicellular organism growthGO:003526440.044
sodium ion transmembrane transportGO:0035725210.043
regulation of metabolic processGO:00192223590.043
brain developmentGO:00074202930.042
phagocytosis engulfmentGO:000691110.042
cellular lipid catabolic processGO:004424230.040
immunoglobulin mediated immune responseGO:001606430.040
regulation of rna biosynthetic processGO:20011412130.040
heart developmentGO:00075073130.039
response to drugGO:004249330.039
heart contractionGO:0060047710.039
response to external biotic stimulusGO:0043207970.039
response to hexoseGO:000974630.039
positive regulation of i kappab kinase nf kappab signalingGO:004312330.039
regulation of nucleocytoplasmic transportGO:004682220.039
cellular nitrogen compound biosynthetic processGO:00442712180.038
Mouse
liver developmentGO:0001889960.038
catabolic processGO:0009056320.037
response to endogenous stimulusGO:0009719830.037
cellular response to organic substanceGO:00713101050.037
lipid storageGO:001991510.037
regulation of cell cycleGO:0051726520.037
transcription from rna polymerase ii promoterGO:0006366800.036
hormone secretionGO:004687920.036
regulation of locomotionGO:0040012550.035
regulation of establishment of protein localizationGO:007020140.035
very long chain fatty acid biosynthetic processGO:004276140.034
phagocytosisGO:000690930.034
i kappab kinase nf kappab signalingGO:000724940.034
neuron differentiationGO:00301823530.033
nik nf kappab signalingGO:003806110.033
neuron developmentGO:00486662620.033
meiotic cell cycle processGO:190304630.033
negative regulation of peptidase activityGO:0010466100.033
regulation of behaviorGO:0050795240.032
cellular response to unfolded proteinGO:003462020.032
urogenital system developmentGO:0001655970.032
proteolysisGO:0006508380.032
Mouse
immune system processGO:00023762410.032
peptide transportGO:001583310.032
defense responseGO:0006952470.032
positive regulation of lymphocyte mediated immunityGO:000270810.032
cellular macromolecule biosynthetic processGO:00346452240.032
regulation of cell communicationGO:00106462320.032
negative regulation of cell communicationGO:0010648960.032
regulation of transcription from rna polymerase ii promoterGO:00063571140.031
regulation of peptidase activityGO:0052547230.031
cell proliferationGO:0008283800.031
behaviorGO:0007610740.031
multi organism reproductive processGO:0044703360.030
negative regulation of cytokine productionGO:000181810.030
adult behaviorGO:003053420.030
cation transmembrane transportGO:0098655650.030
positive regulation of cytokine productionGO:000181920.030
programmed cell deathGO:00125011190.030
negative regulation of metabolic processGO:0009892860.030
cell part morphogenesisGO:00329902460.030
complement activationGO:000695630.029
regulation of transcription dna templatedGO:00063552130.029
carboxylic acid metabolic processGO:0019752220.029
hepaticobiliary system developmentGO:0061008980.029
positive regulation of biological processGO:00485182530.029
regulation of signalingGO:00230512350.029
biosynthetic processGO:00090582940.029
Mouse
regulation of signal transductionGO:00099662250.029
cellular component morphogenesisGO:00329893360.029
cell cycleGO:0007049930.029
regulation of nitrogen compound metabolic processGO:00511712510.028
negative regulation of macromolecule metabolic processGO:0010605760.028
cellular response to stressGO:0033554620.028
response to alkaloidGO:004327920.028
zymogen activationGO:003163830.028
smooth muscle contractionGO:000693920.028
regulation of macromolecule biosynthetic processGO:00105562250.028
positive regulation of rna biosynthetic processGO:1902680570.028
stem cell proliferationGO:007208940.028
negative regulation of nitrogen compound metabolic processGO:0051172590.027
gastrulationGO:00073692080.027
regulation of apoptotic processGO:0042981980.027
cellular localizationGO:0051641970.027
positive regulation of translationGO:004572710.027
membrane lipid biosynthetic processGO:004646720.027
regulation of multicellular organismal developmentGO:20000262230.026
meiotic nuclear divisionGO:000712640.026
cellular component movementGO:00069283350.026
glucose homeostasisGO:004259310.026
heterocycle metabolic processGO:00464832900.026
microtubule based movementGO:0007018330.025
organic cyclic compound biosynthetic processGO:19013622230.025
apoptotic processGO:00069151160.025
system processGO:00030081850.025
regulation of macromolecule metabolic processGO:00602553170.025
positive regulation of cell cycleGO:004578730.024
regulation of protein catabolic processGO:004217610.024
response to carbohydrateGO:000974330.024
regulation of inflammatory responseGO:005072720.024
female sex differentiationGO:004666040.024
regulation of synaptic plasticityGO:004816710.024
heterocycle biosynthetic processGO:00181302150.024
deathGO:00162651210.024
fatty acid biosynthetic processGO:000663340.024
blood vessel developmentGO:00015682460.023
humoral immune response mediated by circulating immunoglobulinGO:000245530.023
inflammatory responseGO:000695480.023
cellular carbohydrate metabolic processGO:004426240.023
regulation of cellular macromolecule biosynthetic processGO:20001122220.023
very long chain fatty acid metabolic processGO:000003840.023
localization of cellGO:00516742440.023
striated muscle cell differentiationGO:00511461290.023
response to other organismGO:0051707970.023
meiotic chromosome segregationGO:004513230.022
regulation of protein transportGO:005122330.022
negative regulation of macromolecule biosynthetic processGO:0010558480.022
response to nitrogen compoundGO:1901698190.022
cellular response to extracellular stimulusGO:003166820.022
protein secretionGO:000930610.022
response to ketoneGO:190165410.022
hematopoietic or lymphoid organ developmentGO:00485341910.022
negative regulation of mapk cascadeGO:004340940.022
cell killingGO:000190620.022
regulation of cellular metabolic processGO:00313233200.022
regulation of sodium ion transportGO:000202820.022
reproductionGO:0000003400.022
membrane invaginationGO:001032410.022
regulation of membrane repolarizationGO:006030610.022
regulation of cysteine type endopeptidase activityGO:2000116210.022
regulation of i kappab kinase nf kappab signalingGO:004312240.021
cellular response to biotic stimulusGO:007121630.021
embryonic cranial skeleton morphogenesisGO:0048701900.021
Zebrafish
hemopoiesisGO:00300971830.021
regulation of nik nf kappab signalingGO:190122210.021
regulation of immune system processGO:0002682340.021
negative regulation of translationGO:001714810.021
cellular response to chemical stimulusGO:00708871570.021
interspecies interaction between organismsGO:004441940.021
specification of symmetryGO:00097992040.021
er nucleus signaling pathwayGO:000698420.021
response to woundingGO:00096111160.020
cell deathGO:00082191210.020
regulation of primary metabolic processGO:00800903110.020
cellular component biogenesisGO:00440851780.020
monocarboxylic acid transportGO:001571850.020
regulation of synapse organizationGO:005080730.020
transcription dna templatedGO:00063511810.020
organelle organizationGO:00069962270.020
energy reserve metabolic processGO:000611220.020
cellular protein catabolic processGO:004425740.020
cellular protein metabolic processGO:00442671290.020
microtubule organizing center organizationGO:003102310.020
sphingolipid biosynthetic processGO:003014820.020
plasminogen activationGO:003163930.020
nucleocytoplasmic transportGO:000691340.020
viral processGO:001603210.020
nuclear importGO:005117030.019
endoplasmic reticulum unfolded protein responseGO:003096820.019
positive regulation of cell divisionGO:005178120.019
light adaptionGO:003636710.019
positive regulation of cellular catabolic processGO:003133130.019
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domainsGO:000246040.019
single organism localizationGO:19025782250.019
positive regulation of extrinsic apoptotic signaling pathwayGO:200123810.019
regulation of circadian rhythmGO:004275240.019
phosphate containing compound metabolic processGO:00067961080.019
protein localization to nucleusGO:003450430.019
regulation of cellular response to oxidative stressGO:190040720.019
establishment of protein localization to organelleGO:007259440.019
regulation of response to stressGO:0080134360.019
nucleobase containing compound biosynthetic processGO:00346542050.019
gtp metabolic processGO:004603940.018
cellular response to topologically incorrect proteinGO:003596720.018
neuromuscular process controlling balanceGO:005088530.018
regulation of protein complex assemblyGO:004325430.018
sexual reproductionGO:0019953360.018
positive regulation of response to stimulusGO:0048584800.018
lipid metabolic processGO:0006629520.018
negative regulation of hydrolase activityGO:0051346100.018
heart loopingGO:0001947940.017
regulation of translational initiationGO:000644610.017
cognitionGO:005089010.017
regulation of cellular protein catabolic processGO:190336210.017
ion transmembrane transportGO:0034220910.017
regulation of systemic arterial blood pressureGO:000307310.017
response to bacteriumGO:0009617580.017
organic substance catabolic processGO:1901575280.017
cellular response to dsrnaGO:007135910.017
response to glucoseGO:000974930.017
negative regulation of signal transductionGO:0009968940.017
immune responseGO:0006955280.017
single organism nuclear importGO:190259330.017
positive regulation of signal transductionGO:0009967560.017
multicellular organismal response to stressGO:003355520.017
negative regulation of cellular catabolic processGO:003133030.017
regulation of stem cell proliferationGO:007209120.017
cellular aromatic compound metabolic processGO:00067252950.017
response to nutrientGO:000758430.017
regulation of endopeptidase activityGO:0052548230.017
dicarboxylic acid metabolic processGO:004364810.017
negative regulation of multi organism processGO:004390130.017
response to oxygen containing compoundGO:1901700550.017
regulation of defense responseGO:0031347140.016
cytokine mediated signaling pathwayGO:001922170.016
macromolecule catabolic processGO:0009057150.016
regulation of system processGO:0044057400.016
protein complex localizationGO:003150310.016
androgen metabolic processGO:000820920.016
protein targeting to nucleusGO:004474430.016
regulation of programmed cell deathGO:00430671010.016
single organism metabolic processGO:00447102170.016
regulation of blood pressureGO:000821710.016
organic cyclic compound metabolic processGO:19013603010.016
protein modification processGO:00362111000.016
membrane fusionGO:006102520.016
positive regulation of catabolic processGO:000989640.016
cellular response to hormone stimulusGO:0032870390.016
kidney developmentGO:0001822920.016
cellular response to external stimulusGO:007149620.016
neuron recognitionGO:0008038180.016
regulation of protein targetingGO:190353320.016
negative regulation of secretionGO:005104820.016
positive regulation of cell communicationGO:0010647560.015
golgi vesicle transportGO:004819330.015
cell motilityGO:00488702440.015
meiosis iGO:000712710.015
protein import into nucleusGO:000660630.015
endocrine processGO:005088620.015
organic substance transportGO:0071702580.015
macromolecule modificationGO:00434121110.015
b cell activationGO:004211320.015
regulation of stem cell differentiationGO:200073640.015
cell migrationGO:00164772370.015
steroid hormone mediated signaling pathwayGO:004340190.015
regulation of oxidative stress induced intrinsic apoptotic signaling pathwayGO:190217520.015
regulation of developmental processGO:00507932470.015
response to unfolded proteinGO:000698620.015
regenerationGO:0031099910.015
response to virusGO:0009615210.015
negative regulation of cell differentiationGO:0045596460.014
determination of left right symmetryGO:00073681790.014
positive regulation of cellular processGO:00485222010.014
positive regulation of apoptotic signaling pathwayGO:200123510.014
regulation of cellular amino acid metabolic processGO:000652100.014
positive regulation of multicellular organismal processGO:0051240520.014
tissue remodelingGO:004877140.014
cellular response to light stimulusGO:007148240.014
regulation of cell proliferationGO:0042127370.014
regulation of biosynthetic processGO:00098892500.014
negative regulation of cellular macromolecule biosynthetic processGO:2000113480.014
regulation of neural precursor cell proliferationGO:200017730.014
regulation of ion transmembrane transporter activityGO:003241220.014
regulation of cell deathGO:00109411030.014
regulation of blood vessel sizeGO:005088020.014
negative regulation of protein serine threonine kinase activityGO:007190120.014
endothelial cell differentiationGO:0045446200.014
myeloid cell differentiationGO:0030099860.014
sensory perception of painGO:001923310.014
glial cell migrationGO:000834730.014
chloride transmembrane transportGO:190247640.014
b cell mediated immunityGO:001972430.014
regulation of protein localization to nucleusGO:190018020.014
long chain fatty acid metabolic processGO:000167610.014
axon developmentGO:00615641660.014
granulocyte migrationGO:0097530110.014
epithelial tube morphogenesisGO:00605621480.013
cellular protein modification processGO:00064641000.013
regulation of nucleic acid templated transcriptionGO:19035062130.013
guanosine containing compound metabolic processGO:190106840.013
cellular response to endogenous stimulusGO:0071495680.013
pericardium morphogenesisGO:000334410.013
organonitrogen compound metabolic processGO:1901564740.013
Mouse
lipid oxidationGO:003444010.013
cellular response to nutrient levelsGO:003166920.013
protein importGO:001703830.013
response to hormoneGO:0009725480.013
carbohydrate biosynthetic processGO:001605110.013
leukocyte mediated cytotoxicityGO:000190910.013
negative regulation of rna metabolic processGO:0051253480.013
fatty acid transportGO:001590810.013
complement activation classical pathwayGO:000695830.013
neuron projection morphogenesisGO:00488121610.013
cellular response to radiationGO:007147840.013
monocarboxylic acid catabolic processGO:007232930.013
anion transportGO:0006820380.013
exocrine system developmentGO:0035272280.013
regulation of localizationGO:00328791040.013
aromatic compound biosynthetic processGO:00194382170.013
response to abiotic stimulusGO:00096281220.013
positive regulation of epithelial cell proliferationGO:005067910.013
ion transportGO:00068111140.012
negative regulation of epithelial cell proliferationGO:005068010.012
positive regulation of immune effector processGO:000269930.012
single organism organelle organizationGO:19025891990.012
cell projection organizationGO:00300302840.012
positive regulation of neural precursor cell proliferationGO:200017910.012
lateral inhibitionGO:004633110.012
negative regulation of cellular biosynthetic processGO:0031327550.012
negative regulation of protein phosphorylationGO:000193340.012
regulation of protein metabolic processGO:0051246560.012
stem cell maintenanceGO:001982740.012
eye developmentGO:00016542770.012
cellular component assembly involved in morphogenesisGO:00109271070.012
regulation of protein import into nucleusGO:004230620.012
regulation of cyclin dependent protein serine threonine kinase activityGO:000007910.012
organic acid transportGO:001584990.012
biological adhesionGO:0022610400.012
regulation of mitotic cell cycleGO:0007346250.012
centrosome organizationGO:005129710.012
response to glucocorticoidGO:005138410.012
regulation of synapse assemblyGO:005196330.012
response to organic substanceGO:00100331530.012
positive regulation of secretionGO:005104710.012
regulation of cellular amine metabolic processGO:003323800.012
organelle fusionGO:004828430.012
regulation of intracellular signal transductionGO:1902531570.012
positive regulation of cell killingGO:003134320.012
response to light stimulusGO:0009416460.012
regulation of intracellular protein transportGO:003315730.012
regulation of lymphocyte mediated immunityGO:000270610.011
muscle contractionGO:0006936180.011
muscle system processGO:0003012200.011
positive regulation of inflammatory responseGO:005072910.011
cell death in response to oxidative stressGO:003647320.011
immune system developmentGO:00025201910.011
dna catabolic processGO:000630810.011
protein catabolic processGO:003016370.011
cellular response to starvationGO:000926710.011
regulation of phosphorylationGO:0042325260.011
natural killer cell mediated immunityGO:000222810.011
morphogenesis of an epitheliumGO:00020093330.011
macromolecule biosynthetic processGO:00090592270.011
mrna cleavage involved in gene silencing by mirnaGO:003527910.011
locomotory behaviorGO:0007626340.011
purine nucleoside monophosphate catabolic processGO:000912840.011
regulation of purine nucleotide catabolic processGO:003312120.011
regulation of extrinsic apoptotic signaling pathwayGO:200123630.011
regulation of symbiosis encompassing mutualism through parasitismGO:004390310.011
intracellular signal transductionGO:0035556850.011
synaptic transmission cholinergicGO:000727140.011
long chain fatty acid biosynthetic processGO:004275910.011
glial cell proliferationGO:001400940.011
regulation of phGO:000688530.011
defense response to other organismGO:0098542330.011
cell cycle g2 m phase transitionGO:004483940.011
cellular component disassemblyGO:002241110.011
amide biosynthetic processGO:004360410.011
Mouse
response to organic cyclic compoundGO:0014070510.011
oxoacid metabolic processGO:0043436310.011
regulation of cysteine type endopeptidase activity involved in apoptotic processGO:0043281200.011
negative regulation of transcription dna templatedGO:0045892450.011
epidermal cell differentiationGO:0009913360.011
negative regulation of apoptotic processGO:0043066550.011
regulation of embryonic developmentGO:0045995470.011
positive regulation of cellular amine metabolic processGO:003324000.011
response to radiationGO:0009314510.011
regulation of ventricular cardiac muscle cell membrane repolarizationGO:006030710.010
positive regulation of nucleotide catabolic processGO:003081310.010
head developmentGO:00603223030.010
somatic muscle developmentGO:000752540.010
regulation of myotube differentiationGO:001083020.010
cellular amine metabolic processGO:004410620.010
regulation of glial cell proliferationGO:006025140.010
negative regulation of programmed cell deathGO:0043069580.010
embryonic skeletal joint developmentGO:007249830.010
fatty acid elongationGO:003049710.010
peptidyl serine modificationGO:001820920.010
regulation of bindingGO:005109830.010
canonical wnt signaling pathwayGO:0060070480.010
positive regulation of cellular metabolic processGO:0031325940.010
response to uvGO:000941130.010
posttranscriptional gene silencing by rnaGO:003519430.010
organonitrogen compound biosynthetic processGO:1901566470.010
Mouse
positive regulation of cell adhesionGO:004578510.010
embryonic heart tube developmentGO:00350501330.010
negative regulation of nucleobase containing compound metabolic processGO:0045934590.010
regulation of glucose importGO:004632410.010
negative regulation of cellular metabolic processGO:0031324770.010
regulation of neuronal synaptic plasticityGO:004816810.010
regulation of tube sizeGO:003515020.010

pcsk1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.017
musculoskeletal system diseaseDOID:1700.014
cancerDOID:16200.014
organ system cancerDOID:005068600.014
disease of cellular proliferationDOID:1456600.014