Danio rerio

20 known processes

pcsk7

proprotein convertase subtilisin/kexin type 7

(Aliases: zgc:158336,wu:fj05c03)

pcsk7 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
peptide metabolic processGO:000651810.548
anterior lateral line system developmentGO:004889890.463
cellular amide metabolic processGO:004360340.377
mechanosensory lateral line system developmentGO:0048881490.365
neuromast developmentGO:0048884460.338
lateral line system developmentGO:0048925760.305
regulation of glucose importGO:004632410.304
appendage morphogenesisGO:0035107560.303
cartilage morphogenesisGO:0060536130.283
biosynthetic processGO:00090582940.260
lateral line developmentGO:0048882660.246
embryonic skeletal system developmentGO:0048706970.245
embryonic skeletal system morphogenesisGO:0048704930.227
regulation of rna metabolic processGO:00512522240.225
appendage developmentGO:0048736800.187
anterior lateral line developmentGO:004889950.179
hormone metabolic processGO:0042445190.176
cellular nitrogen compound metabolic processGO:00346412900.171
embryonic cranial skeleton morphogenesisGO:0048701900.170
sensory organ developmentGO:00074233930.158
organic substance biosynthetic processGO:19015762890.150
protein processingGO:0016485120.148
connective tissue developmentGO:0061448990.126
positive regulation of glucose transportGO:001082810.126
chordate embryonic developmentGO:00430092710.120
regulation of cellular biosynthetic processGO:00313262450.118
multi organism cellular processGO:004476420.117
sensory system developmentGO:0048880760.116
positive regulation of transportGO:005105020.115
lipid oxidationGO:003444010.115
hatchingGO:003518840.113
positive regulation of stress activated mapk cascadeGO:003287430.112
gene expressionGO:00104672520.109
cellular protein catabolic processGO:004425740.109
fin morphogenesisGO:0033334530.104
regulation of fatty acid metabolic processGO:001921710.100
small molecule catabolic processGO:004428230.100
regulation of biological qualityGO:00650082630.099
symbiosis encompassing mutualism through parasitismGO:004440340.097
nik nf kappab signalingGO:003806110.095
viral processGO:001603210.094
cartilage developmentGO:0051216960.090
regulation of cellular metabolic processGO:00313233200.090
regulation of protein localization to nucleusGO:190018020.087
agingGO:000756820.086
nucleic acid templated transcriptionGO:00976591810.085
cellular lipid catabolic processGO:004424230.084
regulation of gene expressionGO:00104682650.084
regulation of glucose transportGO:001082710.083
innate immune responseGO:0045087130.081
i kappab kinase nf kappab signalingGO:000724940.081
regulation of proteolysisGO:0030162240.080
positive regulation of i kappab kinase nf kappab signalingGO:004312330.077
regulation of intracellular protein transportGO:003315730.074
signal transductionGO:00071654550.074
embryonic organ morphogenesisGO:00485622740.074
nitrogen compound metabolic processGO:00068073190.073
nucleobase containing compound metabolic processGO:00061392740.071
nuclear transportGO:005116940.070
embryo development ending in birth or egg hatchingGO:00097922710.070
embryonic viscerocranium morphogenesisGO:0048703520.069
negative regulation of catabolic processGO:000989530.068
synaptic target recognitionGO:000803910.068
monocarboxylic acid catabolic processGO:007232930.067
embryonic organ developmentGO:00485683810.066
positive regulation of lymphocyte mediated immunityGO:000270810.066
organism emergence from protective structureGO:007168440.065
positive regulation of cytokine productionGO:000181920.065
protein targeting to nucleusGO:004474430.065
protein metabolic processGO:00195381830.065
urogenital system developmentGO:0001655970.064
regulation of cytoplasmic transportGO:190364940.063
cellular biosynthetic processGO:00442492860.062
fin developmentGO:0033333770.061
glucose importGO:004632320.060
regulation of protein import into nucleusGO:004230620.059
cellular carbohydrate metabolic processGO:004426240.058
single organism localizationGO:19025782250.058
protein localization to nucleusGO:003450430.057
regulation of protein catabolic processGO:004217610.057
positive regulation of innate immune responseGO:004508980.057
carboxylic acid catabolic processGO:004639530.057
carbohydrate homeostasisGO:003350010.056
positive regulation of jnk cascadeGO:004633030.055
cellular nitrogen compound biosynthetic processGO:00442712180.055
homeostatic processGO:00425921420.055
androgen biosynthetic processGO:000670210.054
rna biosynthetic processGO:00327741810.054
regulation of metabolic processGO:00192223590.054
regulation of striated muscle contractionGO:000694220.054
regulation of cytokine productionGO:000181730.053
regulation of production of molecular mediator of immune responseGO:000270010.051
negative regulation of protein phosphorylationGO:000193340.051
regulation of i kappab kinase nf kappab signalingGO:004312240.051
regulation of reproductive processGO:200024140.050
establishment of localizationGO:00512342440.050
skeletal system morphogenesisGO:00487051020.050
cellular response to lipopolysaccharideGO:007122230.050
lipid storageGO:001991510.048
androgen metabolic processGO:000820920.048
complement activationGO:000695630.048
natural killer cell mediated immunityGO:000222810.047
negative regulation of mapk cascadeGO:004340940.047
regulation of protein complex assemblyGO:004325430.047
larval behaviorGO:003053750.046
positive regulation of stress activated protein kinase signaling cascadeGO:007030430.046
regulation of peptidase activityGO:0052547230.046
transportGO:00068102200.046
immunoglobulin mediated immune responseGO:001606430.045
response to stressGO:00069502630.045
response to topologically incorrect proteinGO:003596620.044
organic cyclic compound biosynthetic processGO:19013622230.044
negative regulation of biological processGO:00485193040.044
regulation of nucleocytoplasmic transportGO:004682220.043
estrogen metabolic processGO:000821020.043
fatty acid beta oxidationGO:000663510.043
peptide transportGO:001583310.042
regulation of carbohydrate metabolic processGO:000610940.042
cellular extravasationGO:004512310.042
neuron recognitionGO:0008038180.041
nuclear importGO:005117030.040
regulation of hormone secretionGO:004688320.040
amide biosynthetic processGO:004360410.040
interspecies interaction between organismsGO:004441940.040
protein complex localizationGO:003150310.040
regulation of nucleobase containing compound metabolic processGO:00192192500.040
establishment of protein localization to organelleGO:007259440.040
response to drugGO:004249330.039
response to monosaccharideGO:003428430.039
negative regulation of reproductive processGO:200024230.039
positive regulation of leukocyte mediated immunityGO:000270510.039
positive regulation of leukocyte mediated cytotoxicityGO:000191210.038
single organism nuclear importGO:190259330.038
response to biotic stimulusGO:0009607970.038
regulation of nitrogen compound metabolic processGO:00511712510.037
skeletal system developmentGO:00015011810.037
maintenance of locationGO:005123540.037
cellular response to topologically incorrect proteinGO:003596720.037
hormone secretionGO:004687920.037
regulation of protein transportGO:005122330.037
proteolysisGO:0006508380.037
organic acid catabolic processGO:001605430.036
positive regulation of immune effector processGO:000269930.036
regulation of inflammatory responseGO:005072720.036
response to alkaloidGO:004327920.035
female sex differentiationGO:004666040.035
phosphorus metabolic processGO:00067931090.035
golgi vesicle transportGO:004819330.035
regulation of cellular protein catabolic processGO:190336210.034
glucose homeostasisGO:004259310.034
protein importGO:001703830.034
nucleic acid metabolic processGO:00903042440.034
negative regulation of hydrolase activityGO:0051346100.034
membrane invaginationGO:001032410.033
plasminogen activationGO:003163930.033
organonitrogen compound metabolic processGO:1901564740.033
meiotic nuclear divisionGO:000712640.033
fatty acid oxidationGO:001939510.033
negative regulation of nucleic acid templated transcriptionGO:1903507450.033
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domainsGO:000246040.033
locomotionGO:00400113130.033
defense responseGO:0006952470.033
lipid catabolic processGO:001604240.033
response to glucoseGO:000974930.032
regulation of ion transmembrane transporter activityGO:003241220.032
er nucleus signaling pathwayGO:000698420.032
neural crest cell migrationGO:0001755420.032
myeloid cell differentiationGO:0030099860.032
multi organism processGO:00517041340.032
response to other organismGO:0051707970.031
cellular macromolecule metabolic processGO:00442603910.031
carbohydrate transportGO:0008643130.031
hormone transportGO:000991420.031
ameboidal type cell migrationGO:00016671430.031
nucleocytoplasmic transportGO:000691340.031
regulation of protein targetingGO:190353320.031
single organism metabolic processGO:00447102170.031
fatty acid transportGO:001590810.031
regulation of locomotionGO:0040012550.030
regulation of macromolecule biosynthetic processGO:00105562250.030
negative regulation of cellular catabolic processGO:003133030.029
phagocytosisGO:000690930.029
negative regulation of peptidase activityGO:0010466100.029
cognitionGO:005089010.029
negative regulation of translationGO:001714810.029
protein maturationGO:0051604120.028
fatty acid catabolic processGO:000906210.028
system processGO:00030081850.028
cellular component movementGO:00069283350.028
cellular response to unfolded proteinGO:003462020.028
negative regulation of protein kinase activityGO:000646940.028
regulation of hormone levelsGO:0010817210.028
response to bacteriumGO:0009617580.027
regulation of transcription dna templatedGO:00063552130.027
detection of external stimulusGO:0009581240.027
positive regulation of cell killingGO:003134320.027
regulation of extrinsic apoptotic signaling pathwayGO:200123630.027
larval developmentGO:000216420.027
regulation of protein ubiquitinationGO:003139630.027
regulation of cell cycleGO:0051726520.027
positive regulation of extrinsic apoptotic signaling pathwayGO:200123810.026
zymogen activationGO:003163830.026
response to carbohydrateGO:000974330.026
carboxylic acid metabolic processGO:0019752220.026
negative regulation of gene expressionGO:0010629650.026
regulation of transferase activityGO:0051338160.026
epithelial cell differentiationGO:00308551160.025
b cell mediated immunityGO:001972430.025
regulation of response to stimulusGO:00485832690.025
melanin metabolic processGO:000658220.025
organic substance transportGO:0071702580.025
protein secretionGO:000930610.025
somatic muscle developmentGO:000752540.025
cell surface receptor signaling pathwayGO:00071663250.025
response to hexoseGO:000974630.024
regulation of rna biosynthetic processGO:20011412130.024
regulation of dna templated transcription in response to stressGO:004362000.024
regulation of establishment of protein localizationGO:007020140.024
positive regulation of cell cycleGO:004578730.024
cellular aromatic compound metabolic processGO:00067252950.024
meiotic cell cycle processGO:190304630.024
regulation of stem cell differentiationGO:200073640.024
multicellular organismal response to stressGO:003355520.024
leukocyte mediated immunityGO:000244360.024
complement activation classical pathwayGO:000695830.024
steroid hormone mediated signaling pathwayGO:004340190.024
negative regulation of defense responseGO:003134820.024
response to external stimulusGO:00096052640.023
positive regulation of cell divisionGO:005178120.023
negative regulation of macromolecule metabolic processGO:0010605760.023
regulation of multicellular organismal processGO:00512392770.023
single organism transportGO:00447652060.023
ion transmembrane transportGO:0034220910.023
negative regulation of response to stimulusGO:00485851040.023
regulation of symbiosis encompassing mutualism through parasitismGO:004390310.023
blood vessel developmentGO:00015682460.022
positive regulation of apoptotic signaling pathwayGO:200123510.022
hormone mediated signaling pathwayGO:000975590.022
catabolic processGO:0009056320.022
negative regulation of protein serine threonine kinase activityGO:007190120.022
negative regulation of cell communicationGO:0010648960.021
very long chain fatty acid biosynthetic processGO:004276140.021
organic cyclic compound metabolic processGO:19013603010.021
regulation of epithelial cell proliferationGO:005067830.021
negative regulation of map kinase activityGO:004340720.021
regulation of signalingGO:00230512350.021
endoplasmic reticulum unfolded protein responseGO:003096820.021
single organism membrane fusionGO:004480120.021
regulation of catalytic activityGO:0050790550.021
stem cell proliferationGO:007208940.021
meiosis iGO:000712710.020
cellular localizationGO:0051641970.020
regulation of signal transductionGO:00099662250.020
positive regulation of inflammatory responseGO:005072910.020
cellular response to stressGO:0033554620.020
positive regulation of neuron deathGO:190121610.020
programmed cell deathGO:00125011190.020
heart processGO:0003015710.019
glial cell proliferationGO:001400940.019
cellular response to biotic stimulusGO:007121630.019
phagocytosis engulfmentGO:000691110.019
cellular response to molecule of bacterial originGO:007121930.019
negative regulation of cellular macromolecule biosynthetic processGO:2000113480.019
positive regulation of programmed cell deathGO:0043068290.019
positive regulation of cellular component biogenesisGO:004408930.019
cellular response to organic substanceGO:00713101050.019
negative regulation of cellular processGO:00485232830.019
autophagyGO:000691440.019
regulation of sodium ion transportGO:000202820.019
heterocycle metabolic processGO:00464832900.019
organonitrogen compound biosynthetic processGO:1901566470.019
transcription from rna polymerase ii promoterGO:0006366800.019
localization of cellGO:00516742440.019
heterocycle biosynthetic processGO:00181302150.019
response to nutrientGO:000758430.019
regulation of bindingGO:005109830.018
regulation of molecular functionGO:0065009700.018
hematopoietic or lymphoid organ developmentGO:00485341910.018
defense response to bacteriumGO:0042742220.018
cellular response to chemical stimulusGO:00708871570.018
calcium mediated signalingGO:001972220.018
regulation of cell communicationGO:00106462320.018
cell motilityGO:00488702440.018
female gonad developmentGO:000858540.018
pericardium morphogenesisGO:000334410.018
cell substrate adhesionGO:003158940.018
endosomal transportGO:001619720.018
regulation of programmed cell deathGO:00430671010.018
regulation of primary metabolic processGO:00800903110.018
interaction with hostGO:005170140.017
cellular response to extracellular stimulusGO:003166820.017
nucleobase containing compound biosynthetic processGO:00346542050.017
positive regulation of secretionGO:005104710.017
production of molecular mediator of immune responseGO:000244020.017
post embryonic organ developmentGO:004856940.017
positive regulation of glucose importGO:004632610.017
antimicrobial humoral responseGO:001973020.017
cell killingGO:000190620.017
regulation of cellular carbohydrate metabolic processGO:001067540.017
organelle organizationGO:00069962270.017
stem cell maintenanceGO:001982740.017
vacuolar transportGO:000703420.016
humoral immune response mediated by circulating immunoglobulinGO:000245530.016
cellular macromolecule biosynthetic processGO:00346452240.016
regulation of hematopoietic progenitor cell differentiationGO:190153210.016
renal absorptionGO:007029310.016
modification of morphology or physiology of other organismGO:003582140.016
regulation of transcription from rna polymerase ii promoter in response to stressGO:004361800.016
defense response to gram negative bacteriumGO:005082980.016
regulation of biosynthetic processGO:00098892500.016
b cell activationGO:004211320.016
cellular protein modification processGO:00064641000.016
myelin assemblyGO:003228810.016
cellular response to starvationGO:000926710.016
endocrine processGO:005088620.016
carbohydrate biosynthetic processGO:001605110.016
leukocyte mediated cytotoxicityGO:000190910.016
positive regulation of dna metabolic processGO:005105410.015
energy reserve metabolic processGO:000611220.015
cellular protein metabolic processGO:00442671290.015
protein targeting to membraneGO:000661210.015
protein dephosphorylationGO:000647030.015
phosphate containing compound metabolic processGO:00067961080.015
rna localizationGO:000640340.015
regulation of macromolecule metabolic processGO:00602553170.015
negative regulation of cytokine productionGO:000181810.015
digestive tract morphogenesisGO:00485462310.015
regulation of cell substrate adhesionGO:001081010.015
cellular response to decreased oxygen levelsGO:003629410.015
protein heterooligomerizationGO:005129110.015
intracellular signal transductionGO:0035556850.015
response to external biotic stimulusGO:0043207970.015
calcium ion importGO:007050940.015
meiotic chromosome segregationGO:004513230.015
regulation of natural killer cell mediated immunityGO:000271510.015
response to chemicalGO:00422213200.015
positive regulation of cellular catabolic processGO:003133130.015
regulation of localizationGO:00328791040.015
mesenchymal cell differentiationGO:0048762870.015
regulation of synaptic plasticityGO:004816710.015
response to unfolded proteinGO:000698620.015
lipid metabolic processGO:0006629520.015
positive regulation of cell substrate adhesionGO:001081110.015
cytokine mediated signaling pathwayGO:001922170.015
protein homooligomerizationGO:005126030.015
positive regulation of blood circulationGO:190352420.015
determination of bilateral symmetryGO:00098552040.015
regulation of cysteine type endopeptidase activityGO:2000116210.015
heart contractionGO:0060047710.015
regulation of transcription from rna polymerase ii promoterGO:00063571140.015
positive regulation of catabolic processGO:000989640.015
positive regulation of catalytic activityGO:0043085250.015
regulation of circadian rhythmGO:004275240.014
positive regulation of gliogenesisGO:001401520.014
fertilizationGO:000956630.014
protein import into nucleusGO:000660630.014
positive regulation of cell adhesionGO:004578510.014
morphogenesis of an epitheliumGO:00020093330.014
regulation of cellular ketone metabolic processGO:001056570.014
positive regulation of epithelial cell differentiationGO:003085820.014
cellular response to external stimulusGO:007149620.014
regulation of mapk cascadeGO:0043408140.014
sensory perception of painGO:001923310.014
cell migrationGO:00164772370.014
regulation of protein modification by small protein conjugation or removalGO:190332030.014
regulation of lymphocyte mediated immunityGO:000270610.014
stem cell divisionGO:001714510.014
ovulation cycleGO:004269820.014
macromolecule biosynthetic processGO:00090592270.014
blood vessel morphogenesisGO:00485142160.014
translational initiationGO:000641330.014
long chain fatty acid biosynthetic processGO:004275910.014
cellular component assemblyGO:00226071700.014
hormone biosynthetic processGO:004244630.014
cellular response to hypoxiaGO:007145610.014
negative regulation of nitrogen compound metabolic processGO:0051172590.013
response to transition metal nanoparticleGO:1990267280.013
regulation of intracellular signal transductionGO:1902531570.013
hepaticobiliary system developmentGO:0061008980.013
regulation of leukocyte mediated immunityGO:000270310.013
cellular homeostasisGO:0019725260.013
inner ear developmentGO:00488391260.013
pectoral fin morphogenesisGO:0035138290.013
positive regulation of cell activationGO:005086710.013
transcription dna templatedGO:00063511810.013
regulation of myotube differentiationGO:001083020.013
monosaccharide transportGO:001574960.013
regulation of systemic arterial blood pressureGO:000307310.013
response to salt stressGO:0009651100.013
negative regulation of multi organism processGO:004390130.013
positive regulation of epithelial cell proliferationGO:005067910.013
positive regulation of secretion by cellGO:190353210.013
stem cell differentiationGO:00488631170.013
regulation of transportGO:0051049450.013
regulation of transmembrane transporter activityGO:002289820.013
regulation of cell migration involved in sprouting angiogenesisGO:009004930.013
amine metabolic processGO:000930820.013
regulation of transporter activityGO:003240920.013
cellular response to drugGO:003569010.013
immune system developmentGO:00025201910.013
positive regulation of cytoskeleton organizationGO:005149530.013
gastrulationGO:00073692080.013
l amino acid transportGO:001580710.013
membrane lipid biosynthetic processGO:004646720.012
detection of stimulusGO:0051606290.012
guanosine containing compound metabolic processGO:190106840.012
immunoglobulin productionGO:000237710.012
nitric oxide biosynthetic processGO:000680920.012
adherens junction organizationGO:003433240.012
internal protein amino acid acetylationGO:000647520.012
nucleoside monophosphate catabolic processGO:000912540.012
fatty acid biosynthetic processGO:000663340.012
regulation of translational initiationGO:000644610.012
sleepGO:003043110.012
regulation of nucleic acid templated transcriptionGO:19035062130.012
peptidyl serine phosphorylationGO:001810510.012
regulation of reactive oxygen species metabolic processGO:200037720.012
regulation of glial cell proliferationGO:006025140.012
positive regulation of nucleoside metabolic processGO:004597910.012
lymphocyte mediated immunityGO:000244950.012
mesenchyme developmentGO:00604851270.012
microtubule organizing center organizationGO:003102310.012
establishment of localization in cellGO:0051649770.012
protein modification processGO:00362111000.012
regulation of muscle contractionGO:000693730.012
regulation of protein metabolic processGO:0051246560.012
ovulation cycle processGO:002260220.012
cellular component disassemblyGO:002241110.012
cellular response to endogenous stimulusGO:0071495680.012
regulation of skeletal muscle tissue developmentGO:004864140.012
mesoderm developmentGO:0007498880.012
organelle membrane fusionGO:009017420.011
immune system processGO:00023762410.011
morphogenesis of an epithelial foldGO:006057110.011
negative regulation of protein import into nucleusGO:004230820.011
regulation of peptidyl tyrosine phosphorylationGO:005073010.011
proteolysis involved in cellular protein catabolic processGO:005160330.011
regulation of cell shapeGO:000836010.011
homeostasis of number of cells within a tissueGO:004887340.011
sphingolipid biosynthetic processGO:003014820.011
regulation of cellular amino acid metabolic processGO:000652100.011
aromatic compound biosynthetic processGO:00194382170.011
smooth muscle contractionGO:000693920.011
modification dependent protein catabolic processGO:001994130.011
regulation of protein bindingGO:004339330.011
neurological system processGO:0050877620.011
protein localization to plasma membraneGO:007265910.011
regulation of response to stressGO:0080134360.011
homeostasis of number of cellsGO:0048872620.011
positive regulation of myeloid cell differentiationGO:004563920.011
positive regulation of epithelial cell migrationGO:001063420.011
cellular response to nutrient levelsGO:003166920.011
multicellular organismal metabolic processGO:004423620.011
regulation of cellular component movementGO:0051270550.011
macromolecule modificationGO:00434121110.011
protein polyubiquitinationGO:000020940.011
neuroblast proliferationGO:000740520.011
negative regulation of protein localization to nucleusGO:190018120.011
long chain fatty acid metabolic processGO:000167610.011
regulation of multicellular organismal developmentGO:20000262230.011
cell proliferation involved in heart morphogenesisGO:006132320.011
regulation of nik nf kappab signalingGO:190122210.011
very long chain fatty acid metabolic processGO:000003840.011
protein activation cascadeGO:007237660.011
centrosome organizationGO:005129710.011
p38mapk cascadeGO:003806610.011
dorsal ventral pattern formationGO:00099531250.010
proteasomal protein catabolic processGO:001049820.010
regulation of stem cell proliferationGO:007209120.010
light adaptionGO:003636710.010
regulation of cell deathGO:00109411030.010
regulation of circadian sleep wake cycleGO:004274910.010
cellular response to radiationGO:007147840.010
deathGO:00162651210.010
nephron developmentGO:0072006310.010
water homeostasisGO:003010440.010
regulation of cellular response to oxidative stressGO:190040720.010
adult behaviorGO:003053420.010
organic substance catabolic processGO:1901575280.010
neural crest cell differentiationGO:0014033720.010
regulation of blood circulationGO:1903522320.010
single organism carbohydrate metabolic processGO:0044723120.010
single organism biosynthetic processGO:0044711710.010
ubiquitin dependent protein catabolic processGO:000651130.010
fatty acid elongationGO:003049710.010
phototransductionGO:000760220.010

pcsk7 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.023
eye diseaseDOID:561400.017
nervous system diseaseDOID:86300.017
sensory system diseaseDOID:005015500.017
eye and adnexa diseaseDOID:149200.017
disease of cellular proliferationDOID:1456600.016
cancerDOID:16200.016
cardiovascular system diseaseDOID:128700.013