Danio rerio

42 known processes

sparc

secreted acidic cysteine rich glycoprotein

(Aliases: hm:zeh0062)

sparc biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
ear developmentGO:00435831270.987
inner ear developmentGO:00488391260.921
sensory organ developmentGO:00074233930.863
embryonic organ developmentGO:00485683810.850
collagen fibril organizationGO:003019910.812
collagen metabolic processGO:003296320.761
collagen biosynthetic processGO:003296420.680
cellular response to lipidGO:0071396390.670
direct ossificationGO:003607230.652
chondrocyte developmentGO:000206340.627
multicellular organismal metabolic processGO:004423620.609
response to amino acidGO:004320020.596
notochord developmentGO:0030903540.577
intramembranous ossificationGO:000195730.549
multicellular organismal macromolecule metabolic processGO:004425920.543
cellular response to chemical stimulusGO:00708871570.520
Mouse
response to hormoneGO:0009725480.503
Rat
response to chemicalGO:00422213200.492
Mouse Rat
regulation of chondrocyte differentiationGO:003233010.470
protein trimerizationGO:007020640.440
mesenchymal cell proliferationGO:001046310.432
regulation of signalingGO:00230512350.407
ossificationGO:0001503230.386
Rat
head developmentGO:00603223030.365
negative regulation of heart contractionGO:004582220.365
signal transductionGO:00071654550.349
cellular response to organic substanceGO:00713101050.343
Mouse
regulation of wnt signaling pathwayGO:0030111530.337
embryonic organ morphogenesisGO:00485622740.322
response to molecule of bacterial originGO:0002237140.318
Rat
otolith developmentGO:0048840320.313
nucleobase containing compound biosynthetic processGO:00346542050.312
positive regulation of cell communicationGO:0010647560.306
positive regulation of signalingGO:0023056560.306
regulation of response to stimulusGO:00485832690.297
cellular response to retinoic acidGO:007130010.296
morphogenesis of an epitheliumGO:00020093330.292
sensory organ morphogenesisGO:00905962000.286
response to organic substanceGO:00100331530.279
Mouse Rat
agingGO:000756820.268
positive regulation of proteolysisGO:0045862100.267
skeletal system developmentGO:00015011810.264
positive regulation of response to stimulusGO:0048584800.262
regulation of cgmp metabolic processGO:003082360.260
wound healingGO:0042060900.258
Rat
positive regulation of signal transductionGO:0009967560.250
cellular response to organic cyclic compoundGO:0071407380.247
single organism metabolic processGO:00447102170.241
craniofacial suture morphogenesisGO:009709420.239
cranial suture morphogenesisGO:006036310.233
extracellular matrix organizationGO:0030198270.233
Fly
response to external stimulusGO:00096052640.212
Rat
skeletal system morphogenesisGO:00487051020.211
embryonic skeletal system developmentGO:0048706970.206
response to woundingGO:00096111160.206
Rat
positive regulation of canonical wnt signaling pathwayGO:009026340.192
cellular response to fibroblast growth factor stimulusGO:0044344220.181
otic vesicle morphogenesisGO:0071600340.180
liver developmentGO:0001889960.178
medial fin morphogenesisGO:0035141140.173
response to oxygen containing compoundGO:1901700550.172
Rat
determination of bilateral symmetryGO:00098552040.165
locomotionGO:00400113130.161
Human
canonical wnt signaling pathwayGO:0060070480.152
vasculature developmentGO:00019442780.144
Human
cytosolic calcium ion transportGO:006040130.133
regulation of epithelial to mesenchymal transitionGO:001071730.132
positive regulation of molecular functionGO:0044093330.124
regulation of cellular metabolic processGO:00313233200.124
cellular response to xenobiotic stimulusGO:0071466350.122
pectoral fin developmentGO:0033339500.119
cellular component assemblyGO:00226071700.118
skin developmentGO:0043588540.114
wnt signaling pathwayGO:0016055800.109
fin developmentGO:0033333770.109
extracellular structure organizationGO:0043062270.103
Fly
inner ear morphogenesisGO:0042472630.102
positive regulation of developmental processGO:0051094500.101
Worm
ion homeostasisGO:0050801410.100
response to abiotic stimulusGO:00096281220.099
Rat
cellular response to endogenous stimulusGO:0071495680.098
regulation of hydrolase activityGO:0051336280.096
regulation of signal transductionGO:00099662250.095
heart morphogenesisGO:00030071560.095
regulation of developmental processGO:00507932470.094
Human Worm
regulation of cell communicationGO:00106462320.094
regulation of erk1 and erk2 cascadeGO:007037240.092
response to lipidGO:0033993600.091
Rat
regulation of biosynthetic processGO:00098892500.090
eye developmentGO:00016542770.089
tissue remodelingGO:004877140.087
visual perceptionGO:0007601170.086
embryonic limb morphogenesisGO:003032620.086
regenerationGO:0031099910.084
positive regulation of wnt signaling pathwayGO:0030177130.080
regulation of locomotionGO:0040012550.079
Human
glomerulus vasculature developmentGO:007201220.079
negative regulation of endodermal cell fate specificationGO:004266480.079
semicircular canal formationGO:006087640.078
positive regulation of hydrolase activityGO:0051345130.077
erk1 and erk2 cascadeGO:007037140.076
protein complex subunit organizationGO:0071822460.075
nitrogen compound metabolic processGO:00068073190.075
negative regulation of biological processGO:00485193040.075
Human
response to retinoic acidGO:003252660.075
ear morphogenesisGO:0042471640.074
regulation of stem cell differentiationGO:200073640.073
angiogenesisGO:00015251580.071
Human
negative regulation of embryonic developmentGO:0045992110.071
response to growth factorGO:0070848390.070
Mouse
otic vesicle formationGO:0030916270.069
tissue regenerationGO:0042246740.065
response to stressGO:00069502630.064
Rat
response to inorganic substanceGO:0010035380.064
Rat
specification of symmetryGO:00097992040.060
cellular response to oxygen containing compoundGO:1901701200.058
nucleobase containing compound metabolic processGO:00061392740.058
membrane repolarizationGO:008600920.056
regulation of molecular functionGO:0065009700.056
extracellular matrix constituent secretionGO:007027830.056
Fly
blood vessel developmentGO:00015682460.054
Human
regulation of insulin like growth factor receptor signaling pathwayGO:004356710.054
bone remodelingGO:004684920.054
single organism transportGO:00447652060.053
Fly
basement membrane assemblyGO:007083130.053
negative regulation of endodermal cell differentiationGO:190322580.051
negative regulation of gastrulationGO:2000542110.050
cartilage developmentGO:0051216960.050
regulation of dna replicationGO:000627530.049
protein heterooligomerizationGO:005129110.048
developmental growthGO:00485891660.048
Worm
regulation of i kappab kinase nf kappab signalingGO:004312240.048
response to nutrientGO:000758430.048
Rat
cellular response to external stimulusGO:007149620.047
hemostasisGO:0007599130.046
cell surface receptor signaling pathwayGO:00071663250.045
endodermal cell differentiationGO:0035987190.045
positive regulation of cellular processGO:00485222010.044
Human
regulation of cell differentiationGO:00455951420.044
negative regulation of dna replicationGO:000815620.043
purine nucleotide biosynthetic processGO:0006164200.043
positive regulation of muscle organ developmentGO:004863610.043
oligodendrocyte differentiationGO:0048709230.042
positive regulation of erk1 and erk2 cascadeGO:007037420.042
regulation of canonical wnt signaling pathwayGO:0060828340.041
trabecula formationGO:006034320.041
regulation of innate immune responseGO:0045088110.041
regulation of endothelial cell proliferationGO:000193610.040
Human
tube morphogenesisGO:00352393490.040
limb bud formationGO:006017420.040
response to external biotic stimulusGO:0043207970.039
Rat
transportGO:00068102200.039
Fly
negative regulation of signalingGO:0023057960.039
organic substance biosynthetic processGO:19015762890.038
cell deathGO:00082191210.037
muscle cell differentiationGO:00426921390.036
response to drugGO:004249330.035
response to fibroblast growth factorGO:0071774220.034
cell cell signalingGO:0007267520.033
reflexGO:006000420.033
bone morphogenesisGO:0060349110.033
neural nucleus developmentGO:0048857150.033
fin regenerationGO:0031101510.033
response to arsenic containing substanceGO:004668550.031
nucleoside phosphate metabolic processGO:0006753280.030
cellular macromolecule biosynthetic processGO:00346452240.030
fin morphogenesisGO:0033334530.030
response to steroid hormoneGO:0048545350.030
Rat
response to estrogenGO:0043627270.030
blood vessel morphogenesisGO:00485142160.029
Human
regulation of multicellular organismal metabolic processGO:004424620.029
regulation of multicellular organismal developmentGO:20000262230.029
Human
regulation of cellular biosynthetic processGO:00313262450.029
cellular response to prostaglandin stimulusGO:007137930.029
proteoglycan metabolic processGO:0006029140.029
cytoskeleton organizationGO:0007010960.029
response to bacteriumGO:0009617580.029
Rat
response to carbohydrateGO:000974330.028
Rat
phosphate containing compound metabolic processGO:00067961080.028
cellular response to acid chemicalGO:007122980.028
regulation of cellular protein metabolic processGO:0032268520.028
response to acid chemicalGO:0001101170.028
Rat
nucleoside biosynthetic processGO:000916320.028
regulation of cartilage developmentGO:006103570.028
regulation of cell activationGO:005086510.027
endodermal cell fate determinationGO:000749320.027
regulation of macromolecule metabolic processGO:00602553170.027
gene expressionGO:00104672520.027
hindbrain developmentGO:0030902910.026
regulation of cellular amine metabolic processGO:003323800.026
cartilage condensationGO:000150230.026
aminoglycan metabolic processGO:000602290.026
positive regulation of protein metabolic processGO:0051247230.026
endothelial cell morphogenesisGO:000188610.026
regulation of cell motilityGO:2000145460.026
Human
cellular component morphogenesisGO:00329893360.025
Human
cellular response to lipopolysaccharideGO:007122230.025
response to hexoseGO:000974630.025
regulation of receptor mediated endocytosisGO:004825940.025
defense response to fungusGO:005083220.024
single organism organelle organizationGO:19025891990.024
homeostatic processGO:00425921420.024
cell morphogenesis involved in differentiationGO:00009041950.024
hepaticobiliary system developmentGO:0061008980.024
positive regulation of macromolecule metabolic processGO:0010604930.023
camera type eye developmentGO:00430102220.023
cellular nitrogen compound biosynthetic processGO:00442712180.023
eye morphogenesisGO:00485921440.023
embryonic eye morphogenesisGO:0048048300.023
multicellular organism growthGO:003526440.023
Worm
regulation of gastrulationGO:0010470240.023
cellular protein modification processGO:00064641000.022
establishment of localizationGO:00512342440.022
Fly
endochondral bone morphogenesisGO:006035080.022
positive regulation of cellular component biogenesisGO:004408930.022
regulation of cardiac muscle cell contractionGO:008600410.022
limb developmentGO:006017380.022
positive regulation of translationGO:004572710.022
intracellular signal transductionGO:0035556850.021
formation of primary germ layerGO:0001704620.021
positive regulation of metabolic processGO:00098931080.021
ion transportGO:00068111140.021
response to lipopolysaccharideGO:0032496130.021
Rat
spemann organizer formation at the embryonic shieldGO:006006320.021
negative regulation of nuclear divisionGO:005178430.021
regulation of cellular component movementGO:0051270550.021
Human
regulation of protein localization to nucleusGO:190018020.020
regulation of cardiac muscle contractionGO:005511720.020
small molecule metabolic processGO:0044281770.020
chondrocyte differentiationGO:000206270.020
response to xenobiotic stimulusGO:0009410450.020
regulation of bone mineralizationGO:003050020.019
cellular response to growth factor stimulusGO:0071363390.019
Mouse
midbrain developmentGO:0030901280.019
regulation of cytoplasmic transportGO:190364940.019
appendage developmentGO:0048736800.019
cartilage morphogenesisGO:0060536130.019
embryonic camera type eye developmentGO:0031076290.019
cell fate specificationGO:0001708680.019
purine ribonucleoside biosynthetic processGO:004612920.019
macromolecular complex subunit organizationGO:0043933740.019
positive regulation of catalytic activityGO:0043085250.019
ribonucleoside biosynthetic processGO:004245520.019
purine containing compound metabolic processGO:0072521290.019
negative regulation of cell fate specificationGO:0009996110.018
cellular protein metabolic processGO:00442671290.018
appendage morphogenesisGO:0035107560.018
meiotic nuclear divisionGO:000712640.018
connective tissue developmentGO:0061448990.017
regulation of epithelial cell proliferationGO:005067830.017
Human
i kappab kinase nf kappab signalingGO:000724940.017
respiratory system developmentGO:006054150.017
Rat Fly
response to oxygen levelsGO:0070482250.017
otic vesicle developmentGO:0071599420.017
bone developmentGO:0060348140.017
Mouse
regulation of cellular macromolecule biosynthetic processGO:20001122220.016
macromolecule biosynthetic processGO:00090592270.016
cellular response to nitrogen compoundGO:190169960.016
heterocycle biosynthetic processGO:00181302150.016
glucose homeostasisGO:004259310.016
positive regulation of cellular metabolic processGO:0031325940.016
positive regulation of cellular protein metabolic processGO:0032270220.015
response to decreased oxygen levelsGO:0036293250.015
cell projection morphogenesisGO:00488582440.015
digestive system developmentGO:00551232890.015
Fly
regulation of skeletal muscle tissue developmentGO:004864140.015
carbohydrate derivative metabolic processGO:1901135610.015
cellular aromatic compound metabolic processGO:00067252950.015
embryonic appendage morphogenesisGO:0035113300.015
bmp signaling pathwayGO:0030509520.015
embryonic skeletal system morphogenesisGO:0048704930.015
negative regulation of multicellular organismal processGO:0051241690.015
Human
regulation of ossificationGO:003027850.015
regulation of response to stressGO:0080134360.015
rna metabolic processGO:00160702190.015
positive regulation of cell differentiationGO:0045597300.015
embryonic skeletal joint morphogenesisGO:006027230.015
skin morphogenesisGO:004358970.014
regulation of multicellular organismal processGO:00512392770.014
Human Worm
regulation of protein targetingGO:190353320.014
positive regulation of cell adhesionGO:004578510.014
regulation of mesodermal cell fate specificationGO:004266190.014
inner ear receptor cell differentiationGO:0060113290.014
negative regulation of dna metabolic processGO:005105340.014
regulation of cell deathGO:00109411030.014
regulation of gene expressionGO:00104682650.014
positive regulation of catabolic processGO:000989640.014
protein modification processGO:00362111000.014
olfactory lobe developmentGO:002198840.014
cellular response to topologically incorrect proteinGO:003596720.014
heart developmentGO:00075073130.014
Rat
insulin like growth factor receptor signaling pathwayGO:004800940.014
heterocycle metabolic processGO:00464832900.013
positive regulation of multicellular organismal processGO:0051240520.013
Human Worm
homeostasis of number of cellsGO:0048872620.013
epithelial cell differentiationGO:00308551160.013
cellular response to steroid hormone stimulusGO:0071383310.013
gliogenesisGO:0042063450.013
positive regulation of immune system processGO:0002684170.013
cell adhesionGO:0007155400.013
organonitrogen compound metabolic processGO:1901564740.013
neuroblast fate commitmentGO:001401710.013
cardiac ventricle developmentGO:000323190.012
cellular response to hormone stimulusGO:0032870390.012
intestinal absorptionGO:005089220.012
cell substrate adhesionGO:003158940.012
negative regulation of blood circulationGO:190352320.012
mesenchyme developmentGO:00604851270.012
regulation of striated muscle contractionGO:000694220.012
proteolysisGO:0006508380.012
vascular endothelial growth factor receptor signaling pathwayGO:0048010130.012
chondroitin sulfate metabolic processGO:003020420.012
response to other organismGO:0051707970.012
Rat
regulation of bone remodelingGO:004685020.012
negative regulation of signal transductionGO:0009968940.012
glucocorticoid metabolic processGO:000821120.012
deathGO:00162651210.012
glial cell fate determinationGO:000740310.012
response to endogenous stimulusGO:0009719830.012
Rat
positive regulation of apoptotic processGO:0043065290.012
regulation of protein import into nucleusGO:004230620.012
regulation of cell substrate adhesionGO:001081010.012
extrinsic apoptotic signaling pathwayGO:009719130.012
stem cell proliferationGO:007208940.012
negative regulation of signal transduction in absence of ligandGO:190109910.012
positive regulation of cytokine productionGO:000181920.012
chemotaxisGO:00069351040.012
negative regulation of wnt signaling pathway involved in heart developmentGO:000330820.012
cellular component biogenesisGO:00440851780.012
actin filament based processGO:0030029640.011
glycosaminoglycan metabolic processGO:003020390.011
positive regulation of cell developmentGO:0010720250.011
renal system vasculature developmentGO:006143720.011
positive regulation of biological processGO:00485182530.011
Human Worm
regulation of cell migrationGO:0030334400.011
Human
endoderm formationGO:0001706290.011
biosynthetic processGO:00090582940.011
pathway restricted smad protein phosphorylationGO:006038910.011
regulation of ventricular cardiac muscle cell membrane repolarizationGO:006030710.011
zymogen activationGO:003163830.011
cell migrationGO:00164772370.011
Human
ectodermal placode developmentGO:0071696370.011
multi organism processGO:00517041340.011
Rat
regulation of protein transportGO:005122330.010
negative regulation of mitosisGO:004583930.010
negative regulation of response to stimulusGO:00485851040.010
sensory perception of mechanical stimulusGO:0050954160.010
regulation of mapk cascadeGO:0043408140.010
neurological system processGO:0050877620.010
muscle structure developmentGO:00610611960.010
cardiac conduction system developmentGO:000316110.010
response to vitaminGO:003327330.010
Rat
transmembrane receptor protein tyrosine kinase signaling pathwayGO:0007169420.010
notch signaling pathwayGO:0007219350.010
negative regulation of muscle tissue developmentGO:190186220.010

sparc disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
connective tissue diseaseDOID:6500.989
musculoskeletal system diseaseDOID:1700.989
disease of anatomical entityDOID:700.989
bone diseaseDOID:008000100.989
bone development diseaseDOID:008000600.989
osteochondrodysplasiaDOID:225600.833
osteogenesis imperfectaDOID:1234700.833
osteoporosisDOID:1147600.243
bone remodeling diseaseDOID:008000500.243
bone resorption diseaseDOID:008001100.243
dysostosisDOID:193400.117
synostosisDOID:1197100.117
neuropathyDOID:87000.019
charcot marie tooth disease type 4DOID:005054100.019
charcot marie tooth diseaseDOID:1059500.019
neuromuscular diseaseDOID:44000.019
nervous system diseaseDOID:86300.019
neurodegenerative diseaseDOID:128900.010
central nervous system diseaseDOID:33100.010