Danio rerio

0 known processes

twist2

twist2

(Aliases: dermo1,zgc:101904)

twist2 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
embryonic organ developmentGO:00485683810.891
cell surface receptor signaling pathwayGO:00071663250.800
chondrocyte developmentGO:000206340.757
growth plate cartilage developmentGO:000341720.754
morphogenesis of an epitheliumGO:00020093330.743
nitrogen compound metabolic processGO:00068073190.703
muscle structure developmentGO:00610611960.652
angioblast cell differentiationGO:003577920.646
blood vessel developmentGO:00015682460.645
regulation of cell communicationGO:00106462320.639
gene expressionGO:00104672520.590
cell morphogenesisGO:00009022890.578
vasculature developmentGO:00019442780.560
epithelial cell morphogenesisGO:000338220.558
gastrulationGO:00073692080.530
endochondral bone growthGO:000341620.524
chordate embryonic developmentGO:00430092710.515
cellular aromatic compound metabolic processGO:00067252950.512
pronephric nephron developmentGO:0039019140.511
multicellular organismal macromolecule metabolic processGO:004425920.508
heart morphogenesisGO:00030071560.493
cartilage development involved in endochondral bone morphogenesisGO:006035180.485
bone mineralizationGO:003028290.472
cell motilityGO:00488702440.440
single organism organelle organizationGO:19025891990.433
cellular component morphogenesisGO:00329893360.410
nucleic acid metabolic processGO:00903042440.405
signal transductionGO:00071654550.405
regulation of signalingGO:00230512350.404
digestive tract developmentGO:00485652650.387
embryonic organ morphogenesisGO:00485622740.382
digestive system developmentGO:00551232890.348
regulation of biomineral tissue developmentGO:007016720.340
regulation of biosynthetic processGO:00098892500.338
notochord developmentGO:0030903540.337
regulation of nucleobase containing compound metabolic processGO:00192192500.324
negative regulation of biological processGO:00485193040.320
cartilage developmentGO:0051216960.318
specification of symmetryGO:00097992040.316
renal system developmentGO:0072001940.312
rna metabolic processGO:00160702190.311
developmental growthGO:00485891660.308
brain developmentGO:00074202930.305
growthGO:00400071740.298
stem cell maintenanceGO:001982740.290
cell part morphogenesisGO:00329902460.287
negative regulation of extrinsic apoptotic signaling pathwayGO:200123720.277
organic cyclic compound metabolic processGO:19013603010.275
cellular nitrogen compound biosynthetic processGO:00442712180.266
cellular macromolecule metabolic processGO:00442603910.262
regulation of cellular biosynthetic processGO:00313262450.259
skeletal system morphogenesisGO:00487051020.252
nephron epithelium morphogenesisGO:007208810.250
neuron projection developmentGO:00311751800.240
negative regulation of cell communicationGO:0010648960.240
organic substance biosynthetic processGO:19015762890.235
regulation of transmembrane receptor protein serine threonine kinase signaling pathwayGO:0090092500.235
regulation of macromolecule metabolic processGO:00602553170.228
transcription from rna polymerase ii promoterGO:0006366800.225
eye morphogenesisGO:00485921440.222
connective tissue developmentGO:0061448990.220
cellular nitrogen compound metabolic processGO:00346412900.212
regulation of nitrogen compound metabolic processGO:00511712510.211
gland developmentGO:00487321430.211
pronephric glomerulus developmentGO:0039021130.209
regulation of gene expressionGO:00104682650.208
heart developmentGO:00075073130.205
organ growthGO:0035265120.194
regulation of transcription dna templatedGO:00063552130.187
extrinsic apoptotic signaling pathwayGO:009719130.185
regulation of rna biosynthetic processGO:20011412130.183
digestive tract morphogenesisGO:00485462310.182
kidney vasculature developmentGO:006144020.179
ossificationGO:0001503230.177
nucleic acid templated transcriptionGO:00976591810.177
axon developmentGO:00615641660.176
cell morphogenesis involved in differentiationGO:00009041950.172
bone morphogenesisGO:0060349110.171
regulation of anatomical structure morphogenesisGO:00226031300.170
cellular component movementGO:00069283350.165
cardiac muscle tissue developmentGO:0048738480.165
axonogenesisGO:00074091520.156
cell projection organizationGO:00300302840.155
tube morphogenesisGO:00352393490.153
camera type eye developmentGO:00430102220.152
cell substrate adhesionGO:003158940.151
muscle cell differentiationGO:00426921390.149
pronephros developmentGO:0048793690.147
regulation of cellular macromolecule biosynthetic processGO:20001122220.146
angiogenesisGO:00015251580.142
ameboidal type cell migrationGO:00016671430.141
positive regulation of biological processGO:00485182530.140
nephron tubule morphogenesisGO:007207810.140
nucleobase containing compound biosynthetic processGO:00346542050.139
regulation of developmental processGO:00507932470.138
nucleobase containing compound metabolic processGO:00061392740.133
localization of cellGO:00516742440.131
renal system vasculature developmentGO:006143720.130
determination of bilateral symmetryGO:00098552040.127
stem cell differentiationGO:00488631170.127
generation of neuronsGO:00486993850.127
blood vessel morphogenesisGO:00485142160.124
transmembrane receptor protein serine threonine kinase signaling pathwayGO:0007178680.124
cell morphogenesis involved in neuron differentiationGO:00486671630.123
establishment of localizationGO:00512342440.121
positive regulation of metabolic processGO:00098931080.118
epithelial cell developmentGO:0002064420.117
endoderm developmentGO:0007492490.117
regulation of extrinsic apoptotic signaling pathwayGO:200123630.117
mesenchyme developmentGO:00604851270.114
cellular macromolecule biosynthetic processGO:00346452240.111
regulation of bmp signaling pathwayGO:0030510390.109
central nervous system myelinationGO:002201020.108
rna biosynthetic processGO:00327741810.107
nucleocytoplasmic transportGO:000691340.107
endochondral bone morphogenesisGO:006035080.106
phosphate containing compound metabolic processGO:00067961080.104
negative regulation of bmp signaling pathwayGO:0030514130.103
regulation of metabolic processGO:00192223590.099
glomerulus vasculature developmentGO:007201220.098
muscle tissue developmentGO:00605371100.098
cell matrix adhesionGO:000716040.098
aromatic compound biosynthetic processGO:00194382170.097
urogenital system developmentGO:0001655970.097
transportGO:00068102200.096
positive regulation of cell activationGO:005086710.096
single organism transportGO:00447652060.094
nephron tubule epithelial cell differentiationGO:007216010.093
sensory organ developmentGO:00074233930.092
striated muscle cell developmentGO:00550021080.091
positive regulation of gastrulationGO:200054320.091
regulation of cellular metabolic processGO:00313233200.090
hemopoiesisGO:00300971830.090
smoothened signaling pathwayGO:0007224300.090
small molecule metabolic processGO:0044281770.089
neuron developmentGO:00486662620.089
embryonic skeletal system morphogenesisGO:0048704930.085
regulation of organ growthGO:004662030.085
inner ear developmentGO:00488391260.083
regulation of developmental growthGO:0048638380.082
regulation of multicellular organismal developmentGO:20000262230.081
regulation of receptor activityGO:001046920.080
regulation of primary metabolic processGO:00800903110.079
mesenchymal cell developmentGO:0014031780.079
striated muscle tissue developmentGO:00147061100.079
cell surface receptor signaling pathway involved in heart developmentGO:0061311200.079
immune system processGO:00023762410.078
mesoderm developmentGO:0007498880.078
regulation of nucleic acid templated transcriptionGO:19035062130.076
bmp signaling pathwayGO:0030509520.075
epibolyGO:0090504410.074
collagen metabolic processGO:003296320.073
stem cell proliferationGO:007208940.071
renal tubule morphogenesisGO:006133310.071
establishment of protein localization to organelleGO:007259440.070
determination of left right symmetryGO:00073681790.069
regionalizationGO:00030022740.069
regulation of response to stimulusGO:00485832690.069
regulation of endodermal cell fate specificationGO:0042663150.068
sensory organ morphogenesisGO:00905962000.068
camera type eye morphogenesisGO:00485931080.067
dorsal ventral pattern formationGO:00099531250.067
response to glucoseGO:000974930.067
intermediate mesoderm developmentGO:004838920.067
positive regulation of cell differentiationGO:0045597300.067
mesenchymal cell proliferationGO:001046310.066
regulation of bone mineralizationGO:003050020.065
positive regulation of gene expressionGO:0010628710.064
nephron developmentGO:0072006310.063
agingGO:000756820.063
nuclear transportGO:005116940.062
neuron projection morphogenesisGO:00488121610.062
regulation of growthGO:0040008420.061
leukocyte proliferationGO:007066110.061
hepaticobiliary system developmentGO:0061008980.061
immune system developmentGO:00025201910.061
smooth muscle tissue developmentGO:004874510.060
stem cell developmentGO:0048864820.060
tissue remodelingGO:004877140.060
transcription dna templatedGO:00063511810.060
kidney developmentGO:0001822920.058
regulation of cell differentiationGO:00455951420.058
regulation of cellular component organizationGO:0051128860.057
response to stressGO:00069502630.057
extracellular structure organizationGO:0043062270.056
developmental growth involved in morphogenesisGO:0060560860.056
neuron differentiationGO:00301823530.056
embryo development ending in birth or egg hatchingGO:00097922710.056
collagen fibril organizationGO:003019910.056
radial glial cell differentiationGO:006001920.055
neural crest cell migrationGO:0001755420.054
developmental process involved in reproductionGO:0003006270.052
transmembrane receptor protein tyrosine kinase signaling pathwayGO:0007169420.052
muscle organ developmentGO:00075171010.050
forebrain developmentGO:0030900960.049
wnt signaling pathway planar cell polarity pathwayGO:006007140.049
muscle cell developmentGO:00550011150.048
embryonic skeletal system developmentGO:0048706970.047
foregut morphogenesisGO:000744040.047
head developmentGO:00603223030.046
formation of primary germ layerGO:0001704620.046
convergent extensionGO:00600261180.046
heterocycle metabolic processGO:00464832900.045
striated muscle cell differentiationGO:00511461290.045
positive regulation of nucleobase containing compound metabolic processGO:0045935690.044
negative regulation of protein phosphorylationGO:000193340.044
proteolysisGO:0006508380.044
spermatid differentiationGO:004851520.044
positive regulation of cellular metabolic processGO:0031325940.043
regulation of mesenchymal cell proliferationGO:001046410.043
enzyme linked receptor protein signaling pathwayGO:00071671060.042
regulation of cell shapeGO:000836010.042
regulation of rna metabolic processGO:00512522240.041
positive regulation of nitrogen compound metabolic processGO:0051173690.040
regulation of cytoplasmic transportGO:190364940.040
hemostasisGO:0007599130.039
regulation of macromolecule biosynthetic processGO:00105562250.039
proximal distal pattern formationGO:000995410.039
regulation of organ morphogenesisGO:2000027350.039
regulation of skeletal muscle fiber developmentGO:004874220.039
eye developmentGO:00016542770.038
epithelial cell differentiationGO:00308551160.038
muscle fiber developmentGO:0048747520.038
cell migrationGO:00164772370.038
embryonic skeletal joint developmentGO:007249830.037
collagen biosynthetic processGO:003296420.037
positive regulation of rna biosynthetic processGO:1902680570.036
regulation of transcription from rna polymerase ii promoterGO:00063571140.036
regulation of cytokine productionGO:000181730.035
negative regulation of signalingGO:0023057960.034
fin morphogenesisGO:0033334530.034
gland morphogenesisGO:0022612130.034
positive regulation of macromolecule metabolic processGO:0010604930.034
amine metabolic processGO:000930820.033
cellular extravasationGO:004512310.033
organic cyclic compound biosynthetic processGO:19013622230.033
embryonic cranial skeleton morphogenesisGO:0048701900.033
organelle organizationGO:00069962270.033
regulation of wnt signaling pathway planar cell polarity pathwayGO:200009520.033
positive regulation of cellular processGO:00485222010.033
regulation of signal transductionGO:00099662250.032
larval developmentGO:000216420.032
positive regulation of rna metabolic processGO:0051254590.032
negative regulation of macromolecule metabolic processGO:0010605760.032
endocrine system developmentGO:0035270650.032
fin developmentGO:0033333770.031
positive regulation of cellular amine metabolic processGO:003324000.031
regulation of mrna splicing via spliceosomeGO:004802430.031
vascular endothelial growth factor receptor signaling pathwayGO:0048010130.031
response to transition metal nanoparticleGO:1990267280.031
regulation of protein import into nucleusGO:004230620.030
neural retina developmentGO:0003407490.030
regulation of glial cell differentiationGO:004568540.030
regulation of cardiac muscle tissue developmentGO:005502410.030
negative regulation of response to stimulusGO:00485851040.030
pronephric nephron tubule developmentGO:003902020.029
negative regulation of signal transductionGO:0009968940.029
somatic stem cell maintenanceGO:003501910.029
wound healingGO:0042060900.029
proximal tubule developmentGO:007201430.029
cartilage condensationGO:000150230.029
cellular localizationGO:0051641970.029
biomineral tissue developmentGO:0031214130.029
angioblast cell migration involved in selective angioblast sproutingGO:003547540.029
epithelial tube morphogenesisGO:00605621480.029
positive regulation of biosynthetic processGO:0009891680.029
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathwayGO:0090101220.029
maintenance of locationGO:005123540.029
notochord morphogenesisGO:0048570170.028
response to hexoseGO:000974630.028
coagulationGO:0050817130.028
regulation of heart growthGO:006042020.028
regulation of cell developmentGO:00602841000.028
protein import into nucleusGO:000660630.028
anterior commissure morphogenesisGO:002196030.028
negative regulation of molecular functionGO:0044092230.027
glomerulus developmentGO:0032835270.027
locomotionGO:00400113130.027
endothelial cell differentiationGO:0045446200.027
response to chemicalGO:00422213200.026
mesendoderm developmentGO:0048382100.026
nuclear importGO:005117030.026
determination of heart left right asymmetryGO:00613711170.026
epithelial cilium movement involved in determination of left right asymmetryGO:006028780.026
extracellular matrix organizationGO:0030198270.026
female sex differentiationGO:004666040.025
regulation of cartilage developmentGO:006103570.025
skeletal system developmentGO:00015011810.025
regulation of protein targetingGO:190353320.025
regulation of cellular amine metabolic processGO:003323800.025
regulation of proteolysisGO:0030162240.025
negative regulation of kinase activityGO:003367340.025
blood coagulationGO:0007596120.024
regulation of alternative mrna splicing via spliceosomeGO:000038110.024
regulation of intracellular protein transportGO:003315730.024
anterior posterior pattern specificationGO:00099521520.024
cell projection assemblyGO:0030031640.024
axon ensheathment in central nervous systemGO:003229120.024
regulation of myotube differentiationGO:001083020.024
regulation of establishment of planar polarityGO:009017540.024
negative regulation of nucleocytoplasmic transportGO:004682320.024
female gonad developmentGO:000858540.024
cell migration involved in gastrulationGO:0042074790.024
appendage morphogenesisGO:0035107560.024
germ line stem cell maintenanceGO:003071820.024
somite developmentGO:0061053960.024
embryonic camera type eye developmentGO:0031076290.023
somitogenesisGO:0001756870.023
regulation of stem cell proliferationGO:007209120.023
regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:200123910.023
phosphorus metabolic processGO:00067931090.023
embryonic heart tube developmentGO:00350501330.023
cardiac atrium developmentGO:000323040.023
mononuclear cell proliferationGO:003294310.023
positive regulation of transcription from rna polymerase ii promoterGO:0045944220.023
cellular protein metabolic processGO:00442671290.023
cell aggregationGO:009874330.023
regulation of cellular amino acid metabolic processGO:000652100.023
regulation of protein catabolic processGO:004217610.022
activation of innate immune responseGO:000221860.022
response to hypoxiaGO:0001666250.022
negative regulation of chemotaxisGO:005092240.022
inner ear receptor cell developmentGO:0060119200.022
epidermis developmentGO:0008544480.022
negative regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:200124010.022
cardiac muscle cell differentiationGO:0055007300.021
regulation of cellular extravasationGO:000269110.021
positive regulation of nucleic acid templated transcriptionGO:1903508570.021
regulation of cellular ketone metabolic processGO:001056570.021
regulation of protein modification by small protein conjugation or removalGO:190332030.020
tissue migrationGO:0090130370.020
embryonic viscerocranium morphogenesisGO:0048703520.020
lymph vessel morphogenesisGO:0036303250.020
wnt signaling pathwayGO:0016055800.020
positive regulation of cellular catabolic processGO:003133130.019
kidney epithelium developmentGO:0072073230.019
positive regulation of leukocyte migrationGO:000268720.019
epithelial cell migrationGO:0010631250.019
angioblast cell migrationGO:003547690.019
negative regulation of sequence specific dna binding transcription factor activityGO:004343320.019
eye photoreceptor cell developmentGO:0042462300.019
extrinsic apoptotic signaling pathway via death domain receptorsGO:000862510.019
cellular response to fibroblast growth factor stimulusGO:0044344220.019
nephron morphogenesisGO:007202820.019
positive regulation of stem cell proliferationGO:200064810.019
lateral inhibitionGO:004633110.019
positive regulation of immune system processGO:0002684170.019
sprouting angiogenesisGO:0002040530.019
regulation of cell deathGO:00109411030.018
establishment of epithelial cell apical basal polarityGO:004519820.018
regulation of smoothened signaling pathwayGO:0008589180.018
mitotic cell cycle processGO:1903047480.018
response to monosaccharideGO:003428430.018
pronephric glomerulus morphogenesisGO:003577560.018
fat soluble vitamin biosynthetic processGO:004236220.018
positive regulation of axon guidanceGO:190266910.018
positive regulation of protein kinase b signalingGO:005189710.018
positive regulation of transcription dna templatedGO:0045893570.018
regulation of peptidyl tyrosine phosphorylationGO:005073010.018
ectodermal placode developmentGO:0071696370.018
odontogenesis of dentin containing toothGO:004247510.018
heart loopingGO:0001947940.017
transmission of nerve impulseGO:0019226190.017
positive regulation of cellular biosynthetic processGO:0031328680.017
negative regulation of muscle tissue developmentGO:190186220.017
protein targeting to nucleusGO:004474430.017
epithelial cilium movementGO:0003351150.017
spinal cord radial glial cell differentiationGO:002153120.017
motor neuron axon guidanceGO:0008045230.017
carboxylic acid metabolic processGO:0019752220.017
nephron epithelium developmentGO:0072009160.017
regulation of proteolysis involved in cellular protein catabolic processGO:190305010.017
biological adhesionGO:0022610400.017
positive regulation of striated muscle cell differentiationGO:005115510.016
heart joggingGO:0003146400.016
response to carbohydrateGO:000974330.016
biosynthetic processGO:00090582940.016
retinal ganglion cell axon guidanceGO:0031290350.016
positive regulation of macromolecule biosynthetic processGO:0010557590.016
homeostatic processGO:00425921420.016
lateral ventricle developmentGO:002167010.016
positive regulation of peptidyl tyrosine phosphorylationGO:005073110.016
regulation of phosphorus metabolic processGO:0051174430.016
ear developmentGO:00435831270.016
ectodermal placode morphogenesisGO:0071697320.016
negative regulation of neuron projection developmentGO:001097790.015
cellular protein modification processGO:00064641000.015
embryonic skeletal joint morphogenesisGO:006027230.015
positive regulation of catabolic processGO:000989640.015
positive regulation of multicellular organismal processGO:0051240520.015
regulation of reproductive processGO:200024140.015
morphogenesis of an epithelial sheetGO:0002011490.015
cell proliferationGO:0008283800.015
astrocyte differentiationGO:004870810.015
mitotic nuclear divisionGO:0007067180.014
distal tubule developmentGO:007201710.014
synaptic vesicle transportGO:004848910.014
notochord cell differentiationGO:0060034180.014
lens fiber cell developmentGO:007030730.014
regulation of multicellular organismal processGO:00512392770.014
regulation of epithelial cell proliferationGO:005067830.014
morphogenesis of a branching epitheliumGO:0061138160.014
activation of mapk activityGO:000018730.014
negative regulation of epithelial cell proliferationGO:005068010.014
cell cycle g1 s phase transitionGO:004484310.014
motor neuron migrationGO:009747540.014
negative regulation of intracellular protein transportGO:009031730.014
cellular ketone metabolic processGO:0042180110.014
protein metabolic processGO:00195381830.014
cardiac atrium morphogenesisGO:000320920.014
ear morphogenesisGO:0042471640.014
oxoacid metabolic processGO:0043436310.014
protein complex localizationGO:003150310.014
negative regulation of canonical wnt signaling pathwayGO:0090090210.014
axis elongationGO:0003401310.014
neurological system processGO:0050877620.013
cellular response to external stimulusGO:007149620.013
signal transduction in absence of ligandGO:003803410.013
endoderm formationGO:0001706290.013
negative regulation of developmental processGO:0051093650.013
negative regulation of cell deathGO:0060548600.013
circulatory system processGO:0003013870.013
nuclear divisionGO:0000280230.013
cell adhesion mediated by integrinGO:003362710.013
negative regulation of leukocyte chemotaxisGO:000268930.013
response to woundingGO:00096111160.013
lipid storageGO:001991510.013
bone remodelingGO:004684920.013
response to organic substanceGO:00100331530.013
negative regulation of apoptotic signaling pathwayGO:2001234100.013
induction of positive chemotaxisGO:005093040.013
t cell activationGO:004211060.013
transcription from rna polymerase iii promoterGO:000638310.013
intracellular signal transductionGO:0035556850.013
regulation of nucleocytoplasmic transportGO:004682220.013
positive regulation of embryonic developmentGO:004001930.012
negative regulation of cell differentiationGO:0045596460.012
negative regulation of signal transduction in absence of ligandGO:190109910.012
protein localization to nucleusGO:003450430.012
otic vesicle developmentGO:0071599420.012
regulation of protein ubiquitinationGO:003139630.012
mesoderm morphogenesisGO:0048332510.012
neural crest cell differentiationGO:0014033720.012
cell projection morphogenesisGO:00488582440.012
tube closureGO:006060610.012
negative regulation of intracellular transportGO:003238730.012
ectodermal placode formationGO:0060788260.012
organ formationGO:0048645170.012
regulation of protein metabolic processGO:0051246560.012
positive regulation of cell communicationGO:0010647560.011
embryonic heart tube morphogenesisGO:00031431080.011
negative regulation of cytoplasmic transportGO:190365020.011
macromolecule biosynthetic processGO:00090592270.011
myotube differentiationGO:0014902450.011
ovulation cycleGO:004269820.011
cellular amino acid metabolic processGO:000652070.011
response to other organismGO:0051707970.011
cytoskeleton organizationGO:0007010960.011
positive regulation of carbohydrate metabolic processGO:004591310.011
reproductive processGO:0022414400.011
cell substrate junction assemblyGO:000704420.011
positive regulation of oligodendrocyte differentiationGO:004871410.011
receptor internalizationGO:003162320.011
regulation of i kappab kinase nf kappab signalingGO:004312240.011
morphogenesis of a branching structureGO:0001763210.011
developmental cell growthGO:0048588520.011
actin cytoskeleton organizationGO:0030036630.011
cardiac muscle tissue growthGO:005501750.011
aorta developmentGO:003590440.011
regulation of bone remodelingGO:004685020.010
epithelial to mesenchymal transitionGO:0001837210.010
heterocycle biosynthetic processGO:00181302150.010
extrinsic apoptotic signaling pathway in absence of ligandGO:009719210.010
lateral line ganglion developmentGO:004889020.010
regulation of ossificationGO:003027850.010
determination of left right asymmetry in lateral mesodermGO:0003140200.010
positive regulation of axon extension involved in axon guidanceGO:004884210.010
multicellular organismal metabolic processGO:004423620.010
striated muscle cell proliferationGO:001485570.010
lymph vessel developmentGO:0001945270.010

twist2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
cancerDOID:16200.096
organ system cancerDOID:005068600.096
disease of cellular proliferationDOID:1456600.096
disease of anatomical entityDOID:700.075
musculoskeletal system diseaseDOID:1700.075
nervous system diseaseDOID:86300.025
disease of mental healthDOID:15000.014
developmental disorder of mental healthDOID:006003700.014
bone diseaseDOID:008000100.011
connective tissue diseaseDOID:6500.011