Danio rerio

119 known processes

jak2a

Janus kinase 2a

jak2a biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
immune system developmentGO:00025201910.226
hematopoietic or lymphoid organ developmentGO:00485341910.205
immune system processGO:00023762410.191
larval developmentGO:000216420.185
regulation of biological qualityGO:00650082630.157
negative regulation of cellular processGO:00485232830.151
cellular macromolecule metabolic processGO:00442603910.124
maintenance of locationGO:005123540.124
protein metabolic processGO:00195381830.122
cellular modified amino acid metabolic processGO:000657530.118
response to nutrientGO:000758430.117
embryonic organ developmentGO:00485683810.117
gland developmentGO:00487321430.114
Zebrafish
erythrocyte homeostasisGO:0034101550.112
cellular macromolecule biosynthetic processGO:00346452240.110
hemopoiesisGO:00300971830.104
regulation of metabolic processGO:00192223590.098
regulation of macromolecule biosynthetic processGO:00105562250.096
erythrocyte differentiationGO:0030218540.094
cell surface receptor signaling pathwayGO:00071663250.086
aromatic compound biosynthetic processGO:00194382170.084
nucleobase containing compound metabolic processGO:00061392740.083
regulation of transcription dna templatedGO:00063552130.082
myeloid cell differentiationGO:0030099860.081
heterocycle biosynthetic processGO:00181302150.080
response to external stimulusGO:00096052640.080
response to chemicalGO:00422213200.080
regulation of gene expressionGO:00104682650.079
cell morphogenesisGO:00009022890.079
rna metabolic processGO:00160702190.078
intracellular signal transductionGO:0035556850.076
nucleobase containing compound biosynthetic processGO:00346542050.075
negative regulation of protein phosphorylationGO:000193340.075
regulation of primary metabolic processGO:00800903110.072
nuclear transportGO:005116940.072
liver developmentGO:0001889960.072
Zebrafish
macromolecule biosynthetic processGO:00090592270.071
organic cyclic compound metabolic processGO:19013603010.070
regulation of nitrogen compound metabolic processGO:00511712510.068
response to drugGO:004249330.068
regulation of establishment of protein localizationGO:007020140.067
regulation of rna biosynthetic processGO:20011412130.066
homeostasis of number of cellsGO:0048872620.065
organic substance biosynthetic processGO:19015762890.064
nucleocytoplasmic transportGO:000691340.064
locomotionGO:00400113130.063
Zebrafish
cellular component morphogenesisGO:00329893360.063
cellular biosynthetic processGO:00442492860.063
positive regulation of biological processGO:00485182530.062
stem cell maintenanceGO:001982740.061
regulation of macromolecule metabolic processGO:00602553170.061
regulation of response to stimulusGO:00485832690.061
cellular response to external stimulusGO:007149620.060
negative regulation of biological processGO:00485193040.060
organic acid metabolic processGO:0006082310.059
hepaticobiliary system developmentGO:0061008980.059
Zebrafish
gene expressionGO:00104672520.059
regulation of multicellular organism growthGO:004001440.059
head developmentGO:00603223030.059
Zebrafish
negative regulation of protein kinase activityGO:000646940.058
regulation of cellular metabolic processGO:00313233200.058
regulation of developmental processGO:00507932470.057
multicellular organism growthGO:003526440.057
digestive tract developmentGO:00485652650.057
regulation of cellular amine metabolic processGO:003323800.056
heterocycle metabolic processGO:00464832900.056
single organism localizationGO:19025782250.055
regulation of cellular amino acid metabolic processGO:000652100.055
cellular amine metabolic processGO:004410620.052
regulation of biosynthetic processGO:00098892500.051
digestive tract morphogenesisGO:00485462310.051
tube morphogenesisGO:00352393490.051
nitrogen compound metabolic processGO:00068073190.050
cellular aromatic compound metabolic processGO:00067252950.050
cell morphogenesis involved in differentiationGO:00009041950.050
regulation of multicellular organismal processGO:00512392770.049
carboxylic acid metabolic processGO:0019752220.049
growthGO:00400071740.049
regulation of rna metabolic processGO:00512522240.049
cellular protein metabolic processGO:00442671290.049
macromolecule modificationGO:00434121110.048
brain developmentGO:00074202930.048
Zebrafish
rna biosynthetic processGO:00327741810.048
amine metabolic processGO:000930820.047
female sex differentiationGO:004666040.047
agingGO:000756820.046
apoptotic processGO:00069151160.046
cellular amino acid metabolic processGO:000652070.046
signal transductionGO:00071654550.046
regulation of cytokine productionGO:000181730.046
regulation of inflammatory responseGO:005072720.045
transportGO:00068102200.044
cellular amide metabolic processGO:004360340.044
positive regulation of map kinase activityGO:004340630.044
regulation of protein transportGO:005122330.043
skeletal system developmentGO:00015011810.043
nuclear exportGO:005116810.043
regulation of cellular ketone metabolic processGO:001056570.043
positive regulation of cellular processGO:00485222010.043
cellular nitrogen compound metabolic processGO:00346412900.042
cellular response to chemical stimulusGO:00708871570.041
cell part morphogenesisGO:00329902460.041
regulation of cellular macromolecule biosynthetic processGO:20001122220.040
positive regulation of catabolic processGO:000989640.040
lipid storageGO:001991510.040
homeostatic processGO:00425921420.040
regulation of reproductive processGO:200024140.040
response to vitaminGO:003327330.039
regulation of cell deathGO:00109411030.039
cell projection organizationGO:00300302840.039
organic cyclic compound biosynthetic processGO:19013622230.039
cellular component movementGO:00069283350.039
Zebrafish
digestive system developmentGO:00551232890.039
Zebrafish
response to stressGO:00069502630.039
oxoacid metabolic processGO:0043436310.039
regulation of hormone secretionGO:004688320.039
cellular ketone metabolic processGO:0042180110.039
organelle organizationGO:00069962270.038
regulation of peptidyl tyrosine phosphorylationGO:005073010.037
transcription dna templatedGO:00063511810.037
leukocyte differentiationGO:0002521250.037
single organism metabolic processGO:00447102170.037
positive regulation of cellular amino acid metabolic processGO:004576400.037
female gonad developmentGO:000858540.037
erythrocyte developmentGO:0048821240.036
positive regulation of cell activationGO:005086710.036
positive regulation of cell cycleGO:004578730.036
somitogenesisGO:0001756870.036
cellular component biogenesisGO:00440851780.035
regulation of protein targetingGO:190353320.035
generation of neuronsGO:00486993850.035
Zebrafish
cellular component assemblyGO:00226071700.035
tissue remodelingGO:004877140.035
cellular response to extracellular stimulusGO:003166820.034
nucleic acid templated transcriptionGO:00976591810.034
regulation of cell differentiationGO:00455951420.034
determination of left right symmetryGO:00073681790.034
regulation of cytoplasmic transportGO:190364940.034
regulation of nucleic acid templated transcriptionGO:19035062130.034
cellular response to starvationGO:000926710.034
alpha amino acid metabolic processGO:190160530.034
establishment of localizationGO:00512342440.034
positive regulation of transportGO:005105020.034
negative regulation of kinase activityGO:003367340.034
deathGO:00162651210.034
cell migrationGO:00164772370.033
Zebrafish
myeloid cell homeostasisGO:0002262560.032
regulation of cell shapeGO:000836010.032
nucleic acid metabolic processGO:00903042440.032
phosphorylationGO:0016310690.032
programmed cell deathGO:00125011190.032
meiotic nuclear divisionGO:000712640.032
regulation of cell activationGO:005086510.032
activation of mapk activityGO:000018730.031
small molecule metabolic processGO:0044281770.031
cellular response to nutrient levelsGO:003166920.031
protein localization to nucleusGO:003450430.031
extrinsic apoptotic signaling pathwayGO:009719130.031
regulation of cellular biosynthetic processGO:00313262450.031
regulation of bindingGO:005109830.030
regulation of protein complex assemblyGO:004325430.030
positive regulation of cellular catabolic processGO:003133130.030
cell motilityGO:00488702440.030
Zebrafish
regulation of immune system processGO:0002682340.029
cell substrate adhesionGO:003158940.029
regulation of cell communicationGO:00106462320.029
central nervous system developmentGO:00074173870.029
Zebrafish
negative regulation of protein complex assemblyGO:003133310.029
developmental growthGO:00485891660.029
morphogenesis of an epitheliumGO:00020093330.028
positive regulation of biosynthetic processGO:0009891680.028
embryonic hemopoiesisGO:0035162530.028
development of primary female sexual characteristicsGO:004654540.028
neuron differentiationGO:00301823530.028
Zebrafish
protein import into nucleusGO:000660630.028
phagocytosisGO:000690930.027
regulation of epithelial cell proliferationGO:005067830.027
regulation of nucleocytoplasmic transportGO:004682220.027
embryo development ending in birth or egg hatchingGO:00097922710.027
cellular response to lipopolysaccharideGO:007122230.027
protein modification processGO:00362111000.027
cell projection morphogenesisGO:00488582440.027
regulation of translational initiationGO:000644610.027
positive regulation of protein kinase b signalingGO:005189710.026
positive regulation of cell adhesionGO:004578510.026
response to alkaloidGO:004327920.026
taxisGO:00423301090.026
single organism nuclear importGO:190259330.026
positive regulation of macromolecule metabolic processGO:0010604930.026
embryonic organ morphogenesisGO:00485622740.026
ubiquitin dependent protein catabolic processGO:000651130.026
multicellular organismal metabolic processGO:004423620.026
axon developmentGO:00615641660.025
translational initiationGO:000641330.025
regulation of circadian rhythmGO:004275240.025
regulation of protein import into nucleusGO:004230620.025
spindle assemblyGO:005122520.025
regulation of anatomical structure morphogenesisGO:00226031300.025
regulation of intracellular protein transportGO:003315730.025
positive regulation of metabolic processGO:00098931080.025
positive regulation of cellular amine metabolic processGO:003324000.025
biosynthetic processGO:00090582940.025
proteasomal protein catabolic processGO:001049820.025
neuron developmentGO:00486662620.024
regulation of signal transductionGO:00099662250.024
negative regulation of metabolic processGO:0009892860.024
myeloid cell developmentGO:0061515320.024
chemical homeostasisGO:0048878490.024
regionalizationGO:00030022740.024
positive regulation of translationGO:004572710.023
vasculature developmentGO:00019442780.023
regulation of multicellular organismal developmentGO:20000262230.023
b cell activationGO:004211320.023
cytokinesisGO:000091030.023
localization of cellGO:00516742440.023
Zebrafish
intracellular receptor signaling pathwayGO:0030522300.023
organonitrogen compound metabolic processGO:1901564740.023
modification dependent macromolecule catabolic processGO:004363230.023
hatching gland developmentGO:004878530.023
phagocytosis engulfmentGO:000691110.023
regulation of programmed cell deathGO:00430671010.023
axonogenesisGO:00074091520.023
guanosine containing compound metabolic processGO:190106840.023
positive regulation of nitrogen compound metabolic processGO:0051173690.022
phosphate containing compound metabolic processGO:00067961080.022
cellular transition metal ion homeostasisGO:004691630.022
protein polymerizationGO:005125840.022
response to woundingGO:00096111160.022
lipid homeostasisGO:005508830.022
regulation of nucleobase containing compound metabolic processGO:00192192500.022
b cell differentiationGO:003018310.022
determination of bilateral symmetryGO:00098552040.022
somatic muscle developmentGO:000752540.022
heart developmentGO:00075073130.022
defense responseGO:0006952470.021
regulation of synapse organizationGO:005080730.021
response to glucocorticoidGO:005138410.021
negative regulation of secretionGO:005104820.021
positive regulation of cytokine productionGO:000181920.021
regulation of protein catabolic processGO:004217610.021
regulation of intracellular signal transductionGO:1902531570.021
regulation of blood vessel sizeGO:005088020.021
proteasome mediated ubiquitin dependent protein catabolic processGO:004316120.021
organic substance transportGO:0071702580.021
positive regulation of gene expressionGO:0010628710.021
protein importGO:001703830.021
regulation of catalytic activityGO:0050790550.021
gtp metabolic processGO:004603940.020
peptide transportGO:001583310.020
cellular nitrogen compound biosynthetic processGO:00442712180.020
synaptic growth at neuromuscular junctionGO:005112420.020
regulation of stem cell differentiationGO:200073640.020
protein secretionGO:000930610.020
positive regulation of apoptotic signaling pathwayGO:200123510.020
transcription from rna polymerase ii promoterGO:0006366800.020
hormone transportGO:000991420.020
regulation of synapse assemblyGO:005196330.020
primitive hemopoiesisGO:0060215270.020
blood vessel developmentGO:00015682460.020
regulation of erythrocyte differentiationGO:004564620.020
cartilage developmentGO:0051216960.019
erk1 and erk2 cascadeGO:007037140.019
neuron neuron synaptic transmissionGO:000727010.019
centrosome organizationGO:005129710.019
microtubule organizing center organizationGO:003102310.019
regulation of protein bindingGO:004339330.019
specification of symmetryGO:00097992040.019
response to xenobiotic stimulusGO:0009410450.019
positive regulation of peptidyl tyrosine phosphorylationGO:005073110.019
regulation of signalingGO:00230512350.019
negative regulation of myeloid cell differentiationGO:004563810.019
positive regulation of cellular biosynthetic processGO:0031328680.019
wound healingGO:0042060900.019
regulation of production of molecular mediator of immune responseGO:000270010.019
negative regulation of response to stimulusGO:00485851040.019
dicarboxylic acid metabolic processGO:004364810.019
response to hexoseGO:000974630.019
macromolecular complex disassemblyGO:003298410.019
cell cycle g1 s phase transitionGO:004484310.019
positive regulation of secretion by cellGO:190353210.019
forebrain developmentGO:0030900960.018
regulation of apoptotic processGO:0042981980.018
response to organic substanceGO:00100331530.018
cellular protein modification processGO:00064641000.018
regulation of extrinsic apoptotic signaling pathwayGO:200123630.018
negative regulation of leukocyte differentiationGO:190210610.018
negative regulation of cytokine productionGO:000181810.018
protein targeting to nucleusGO:004474430.018
establishment of protein localization to organelleGO:007259440.018
autophagyGO:000691440.018
regulation of blood pressureGO:000821710.018
regulation of neurotransmitter transportGO:005158810.018
cellular protein catabolic processGO:004425740.018
response to uvGO:000941130.018
response to glucoseGO:000974930.018
positive regulation of secretionGO:005104710.018
negative regulation of chromosome organizationGO:200125110.018
neuron projection morphogenesisGO:00488121610.018
primary neural tube formationGO:001402010.018
mitochondrion organizationGO:000700540.018
rna transportGO:005065820.018
single fertilizationGO:000733830.018
cytoskeleton dependent cytokinesisGO:006164030.017
negative regulation of catabolic processGO:000989530.017
regulation of wound healingGO:006104120.017
regulation of protein localization to nucleusGO:190018020.017
adherens junction organizationGO:003433240.017
negative regulation of map kinase activityGO:004340720.017
proteolysis involved in cellular protein catabolic processGO:005160330.017
circulatory system processGO:0003013870.017
chordate embryonic developmentGO:00430092710.017
segmentationGO:0035282970.017
dorsal ventral pattern formationGO:00099531250.017
cellular response to organic substanceGO:00713101050.017
single organism organelle organizationGO:19025891990.017
developmental programmed cell deathGO:001062340.017
positive regulation of response to stimulusGO:0048584800.017
nuclear importGO:005117030.017
lymphocyte homeostasisGO:000226010.017
negative regulation of protein serine threonine kinase activityGO:007190120.017
regulation of protein metabolic processGO:0051246560.017
neuron projection developmentGO:00311751800.017
regulation of mrna processingGO:005068430.017
immune responseGO:0006955280.017
positive regulation of rna metabolic processGO:0051254590.017
regulation of cell cycleGO:0051726520.016
response to corticosteroidGO:003196010.016
positive regulation of i kappab kinase nf kappab signalingGO:004312330.016
negative regulation of cellular catabolic processGO:003133030.016
negative regulation of macromolecule metabolic processGO:0010605760.016
protein complex biogenesisGO:0070271300.016
eye developmentGO:00016542770.016
gtp catabolic processGO:000618420.016
sequestering of metal ionGO:005123830.016
meiosis iiGO:000713510.016
rna localizationGO:000640340.016
cell matrix adhesionGO:000716040.016
protein phosphorylationGO:0006468470.016
protein complex disassemblyGO:004324110.016
regulation of erk1 and erk2 cascadeGO:007037240.016
protein stabilizationGO:005082120.016
positive regulation of signal transductionGO:0009967560.016
negative regulation of nuclear divisionGO:005178430.016
g1 s transition of mitotic cell cycleGO:000008210.016
meiotic chromosome segregationGO:004513230.016
epithelial tube morphogenesisGO:00605621480.016
negative regulation of defense responseGO:003134820.016
positive regulation of immune system processGO:0002684170.016
regulation of microtubule cytoskeleton organizationGO:007050730.016
cell morphogenesis involved in neuron differentiationGO:00486671630.016
positive regulation of signalingGO:0023056560.015
positive regulation of cytosolic calcium ion concentrationGO:000720440.015
regulation of i kappab kinase nf kappab signalingGO:004312240.015
negative regulation of mapk cascadeGO:004340940.015
negative regulation of protein transportGO:005122430.015
protein complex assemblyGO:0006461300.015
regulation of metal ion transportGO:001095940.015
lymphocyte proliferationGO:004665110.015
determination of heart left right asymmetryGO:00613711170.015
negative regulation of epithelial cell proliferationGO:005068010.015
regulation of molecular functionGO:0065009700.015
multi organism processGO:00517041340.015
protein acetylationGO:000647320.015
antimicrobial humoral responseGO:001973020.015
cell cycle processGO:0022402530.015
small gtpase mediated signal transductionGO:000726480.015
regulation of jak stat cascadeGO:004642530.015
bone remodelingGO:004684920.015
regulation of protein polymerizationGO:003227120.015
negative regulation of signal transductionGO:0009968940.015
macromolecular complex assemblyGO:0065003350.015
purine ribonucleoside monophosphate catabolic processGO:000916940.015
regulation of nucleotide catabolic processGO:003081120.015
regulation of protein modification by small protein conjugation or removalGO:190332030.015
positive regulation of canonical wnt signaling pathwayGO:009026340.015
regulation of cell matrix adhesionGO:000195210.015
mononuclear cell proliferationGO:003294310.015
symbiosis encompassing mutualism through parasitismGO:004440340.015
embryonic skeletal system morphogenesisGO:0048704930.015
peptidyl serine modificationGO:001820920.015
protein acylationGO:004354330.015
cellular component disassemblyGO:002241110.015
meiotic cell cycle processGO:190304630.015
transition metal ion transportGO:000004160.014
negative regulation of cellular metabolic processGO:0031324770.014
negative regulation of secretion by cellGO:190353120.014
complement activationGO:000695630.014
ameboidal type cell migrationGO:00016671430.014
angiogenesisGO:00015251580.014
connective tissue developmentGO:0061448990.014
positive regulation of macromolecule biosynthetic processGO:0010557590.014
striated muscle cell developmentGO:00550021080.014
regulation of jun kinase activityGO:004350630.014
ribonucleoside monophosphate catabolic processGO:000915840.014
microtubule polymerization or depolymerizationGO:003110930.014
neurotransmitter transportGO:000683620.014
regulation of cellular protein metabolic processGO:0032268520.014
negative regulation of programmed cell deathGO:0043069580.014
production of molecular mediator of immune responseGO:000244020.014
membrane invaginationGO:001032410.014
macromolecular complex subunit organizationGO:0043933740.014
regulation of autophagyGO:001050630.014
cellular response to estrogen stimulusGO:0071391240.014
blood circulationGO:0008015870.013
guanosine containing compound catabolic processGO:190106920.013
primitive erythrocyte differentiationGO:006031950.013
cell substrate junction assemblyGO:000704420.013
negative regulation of gene expressionGO:0010629650.013
positive regulation of nucleic acid templated transcriptionGO:1903508570.013
nucleoside monophosphate catabolic processGO:000912540.013
interspecies interaction between organismsGO:004441940.013
negative regulation of intracellular transportGO:003238730.013
circadian sleep wake cycleGO:004274520.013
carbohydrate homeostasisGO:003350010.013
blood vessel morphogenesisGO:00485142160.013
response to estrogenGO:0043627270.013
apoptotic process involved in developmentGO:190274220.013
cellular response to xenobiotic stimulusGO:0071466350.013
positive regulation of rna biosynthetic processGO:1902680570.013
peptidyl lysine acetylationGO:001839420.013
cell proliferationGO:0008283800.013
pancreas developmentGO:0031016840.013
Zebrafish
embryonic cranial skeleton morphogenesisGO:0048701900.013
positive regulation of immune effector processGO:000269930.013
system processGO:00030081850.013
oocyte anterior posterior axis specificationGO:000731440.013
leukocyte proliferationGO:007066110.013
regulation of systemic arterial blood pressureGO:000307310.013
regulation of tube sizeGO:003515020.013
bmp signaling pathwayGO:0030509520.013
positive regulation of cell divisionGO:005178120.013
positive regulation of leukocyte differentiationGO:190210710.013
positive regulation of developmental processGO:0051094500.013
regulation of protein complex disassemblyGO:004324410.013
myeloid leukocyte differentiationGO:0002573150.013
regulation of sodium ion transportGO:000202820.013
positive regulation of erk1 and erk2 cascadeGO:007037420.013
oocyte maturationGO:000155640.013
action potentialGO:0001508190.013
peptidyl threonine phosphorylationGO:001810710.013
tube closureGO:006060610.013
negative regulation of ras protein signal transductionGO:004658010.013
glucose importGO:004632320.013
single organism transportGO:00447652060.013
endocrine processGO:005088620.013
extrinsic apoptotic signaling pathway via death domain receptorsGO:000862510.013
protein complex localizationGO:003150310.013
epithelial cell differentiationGO:00308551160.013
protein kinase b signalingGO:004349190.012
negative regulation of protein localization to nucleusGO:190018120.012
regulation of chromosome segregationGO:005198310.012
leukocyte homeostasisGO:000177620.012
organism emergence from protective structureGO:007168440.012
mitotic cell cycleGO:0000278640.012
secondary metabolic processGO:001974830.012
regenerationGO:0031099910.012
carbon dioxide transportGO:001567030.012
adult behaviorGO:003053420.012
viral processGO:001603210.012
spermatid developmentGO:000728620.012
response to ketoneGO:190165410.012
endosomal transportGO:001619720.012
heart loopingGO:0001947940.012
cytoplasm organizationGO:000702840.012
positive regulation of myeloid cell differentiationGO:004563920.012
circadian sleep wake cycle processGO:002241020.012
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domainsGO:000246040.012
ras protein signal transductionGO:000726570.012
protein depolymerizationGO:005126110.012
lateral inhibitionGO:004633110.012
somite developmentGO:0061053960.012
negative regulation of cytoplasmic transportGO:190365020.012
response to organic cyclic compoundGO:0014070510.012
regulation of cell killingGO:003134120.012
mitotic cytokinesisGO:000028130.012
response to foodGO:003209410.012
maternal determination of anterior posterior axis embryoGO:000835840.012
pole plasm assemblyGO:000731540.012
somatic stem cell maintenanceGO:003501910.012
positive regulation of cellular component biogenesisGO:004408930.012
regulation of meiotic cell cycleGO:005144510.012
cell agingGO:000756920.012
negative regulation of cell communicationGO:0010648960.012
fertilizationGO:000956630.012

jak2a disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of cellular proliferationDOID:1456600.031
organ system cancerDOID:005068600.031
cancerDOID:16200.031
disease of anatomical entityDOID:700.025
nervous system diseaseDOID:86300.021
disease of metabolismDOID:001466700.016
inherited metabolic disorderDOID:65500.016
eye and adnexa diseaseDOID:149200.016
sensory system diseaseDOID:005015500.016
eye diseaseDOID:561400.016
retinal diseaseDOID:567900.012
cardiovascular system diseaseDOID:128700.012