Danio rerio

44 known processes

ptpn21

protein tyrosine phosphatase, non-receptor type 21

(Aliases: pez,ptpn14)

ptpn21 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
cellular component assemblyGO:00226071700.305
cellular macromolecule metabolic processGO:00442603910.251
heart developmentGO:00075073130.220
nitrogen compound metabolic processGO:00068073190.216
positive regulation of cellular component biogenesisGO:004408930.195
cellular macromolecule biosynthetic processGO:00346452240.178
central nervous system developmentGO:00074173870.167
cellular nitrogen compound biosynthetic processGO:00442712180.161
head developmentGO:00603223030.157
ameboidal type cell migrationGO:00016671430.147
nucleobase containing compound biosynthetic processGO:00346542050.142
regulation of cell shapeGO:000836010.130
response to fluid shear stressGO:003440520.126
regulation of rna metabolic processGO:00512522240.126
blood vessel developmentGO:00015682460.126
eye developmentGO:00016542770.124
negative regulation of cellular processGO:00485232830.115
agingGO:000756820.115
sensory organ developmentGO:00074233930.112
nucleic acid metabolic processGO:00903042440.111
macromolecule biosynthetic processGO:00090592270.109
regulation of gene expressionGO:00104682650.108
transmembrane receptor protein serine threonine kinase signaling pathwayGO:0007178680.105
positive regulation of biological processGO:00485182530.105
regulation of biosynthetic processGO:00098892500.098
artery developmentGO:0060840220.098
chordate embryonic developmentGO:00430092710.095
hemopoiesisGO:00300971830.093
cellular response to external stimulusGO:007149620.090
regulation of cellular metabolic processGO:00313233200.090
embryonic organ developmentGO:00485683810.089
regulation of nucleic acid templated transcriptionGO:19035062130.087
establishment of localizationGO:00512342440.087
brain developmentGO:00074202930.081
regulation of transmembrane receptor protein serine threonine kinase signaling pathwayGO:0090092500.081
protein localization to nucleusGO:003450430.080
cellular component morphogenesisGO:00329893360.075
larval developmentGO:000216420.073
gene expressionGO:00104672520.070
mitotic dna damage checkpointGO:004477340.070
cellular biosynthetic processGO:00442492860.069
cell morphogenesisGO:00009022890.068
regulation of metabolic processGO:00192223590.067
response to chemicalGO:00422213200.067
cellular response to extracellular stimulusGO:003166820.065
regulation of nucleobase containing compound metabolic processGO:00192192500.065
retina development in camera type eyeGO:00600411460.064
rna biosynthetic processGO:00327741810.063
regulation of protein transportGO:005122330.060
regulation of cellular biosynthetic processGO:00313262450.060
positive regulation of biosynthetic processGO:0009891680.060
system processGO:00030081850.058
regulation of macromolecule biosynthetic processGO:00105562250.058
regulation of multicellular organismal processGO:00512392770.057
embryo development ending in birth or egg hatchingGO:00097922710.057
development of primary female sexual characteristicsGO:004654540.056
cellular nitrogen compound metabolic processGO:00346412900.055
signal transductionGO:00071654550.055
protein import into nucleusGO:000660630.055
enzyme linked receptor protein signaling pathwayGO:00071671060.054
female sex differentiationGO:004666040.053
camera type eye developmentGO:00430102220.052
mitotic dna integrity checkpointGO:004477440.052
cell matrix adhesionGO:000716040.052
meiotic nuclear divisionGO:000712640.052
cognitionGO:005089010.052
heterocycle metabolic processGO:00464832900.051
multi organism processGO:00517041340.051
single organism nuclear importGO:190259330.051
response to alkaloidGO:004327920.051
establishment of protein localization to organelleGO:007259440.051
organic cyclic compound biosynthetic processGO:19013622230.050
organic cyclic compound metabolic processGO:19013603010.050
generation of neuronsGO:00486993850.049
vascular endothelial growth factor signaling pathwayGO:003808430.049
cell projection organizationGO:00300302840.048
adherens junction organizationGO:003433240.048
transportGO:00068102200.047
response to external stimulusGO:00096052640.047
forebrain developmentGO:0030900960.047
cellular aromatic compound metabolic processGO:00067252950.046
female gonad developmentGO:000858540.046
regulation of extrinsic apoptotic signaling pathwayGO:200123630.046
single organism metabolic processGO:00447102170.046
morphogenesis of an epitheliumGO:00020093330.046
organelle organizationGO:00069962270.046
regulation of establishment of protein localizationGO:007020140.046
regulation of metal ion transportGO:001095940.045
regulation of cytokine productionGO:000181730.045
cell substrate adhesionGO:003158940.045
organic substance biosynthetic processGO:19015762890.045
nucleocytoplasmic transportGO:000691340.045
protein targeting to nucleusGO:004474430.045
peptide transportGO:001583310.044
regulation of transcription from rna polymerase ii promoterGO:00063571140.044
hematopoietic or lymphoid organ developmentGO:00485341910.044
regulation of intracellular protein transportGO:003315730.044
positive regulation of transportGO:005105020.043
regulation of protein targetingGO:190353320.043
g1 s transition of mitotic cell cycleGO:000008210.043
aromatic compound biosynthetic processGO:00194382170.043
cellular response to nutrient levelsGO:003166920.043
regulation of cell communicationGO:00106462320.043
post embryonic organ developmentGO:004856940.043
protein metabolic processGO:00195381830.043
regulation of production of molecular mediator of immune responseGO:000270010.042
regionalizationGO:00030022740.042
response to organic substanceGO:00100331530.041
regulation of protein import into nucleusGO:004230620.041
regulation of protein localization to nucleusGO:190018020.040
angiogenesisGO:00015251580.040
regulation of macromolecule metabolic processGO:00602553170.040
somitogenesisGO:0001756870.039
regulation of cellular macromolecule biosynthetic processGO:20001122220.039
cartilage condensationGO:000150230.039
regulation of response to stimulusGO:00485832690.038
regulation of epithelial cell proliferationGO:005067830.038
transcription from rna polymerase ii promoterGO:0006366800.038
nuclear importGO:005117030.038
blood vessel morphogenesisGO:00485142160.038
nitric oxide metabolic processGO:004620920.038
embryonic organ morphogenesisGO:00485622740.038
regulation of nucleocytoplasmic transportGO:004682220.038
rna metabolic processGO:00160702190.037
single organism organelle organizationGO:19025891990.037
kidney developmentGO:0001822920.036
cell surface receptor signaling pathwayGO:00071663250.036
positive regulation of stem cell proliferationGO:200064810.036
nucleobase containing compound metabolic processGO:00061392740.036
response to ketoneGO:190165410.036
immune system processGO:00023762410.036
regulation of filopodium assemblyGO:005148920.036
regulation of nitrogen compound metabolic processGO:00511712510.035
cell migration involved in gastrulationGO:0042074790.035
regulation of dna replicationGO:000627530.035
regulation of biological qualityGO:00650082630.034
response to drugGO:004249330.034
negative regulation of programmed cell deathGO:0043069580.034
actin filament based processGO:0030029640.034
mitochondrion organizationGO:000700540.034
regulation of synaptic plasticityGO:004816710.034
protein importGO:001703830.034
nitric oxide biosynthetic processGO:000680920.033
bmp signaling pathwayGO:0030509520.033
response to stressGO:00069502630.033
apoptotic processGO:00069151160.032
b cell activationGO:004211320.032
synaptic target recognitionGO:000803910.032
renal system developmentGO:0072001940.032
biosynthetic processGO:00090582940.032
regulation of primary metabolic processGO:00800903110.032
venous blood vessel developmentGO:006084190.032
lipid storageGO:001991510.031
positive regulation of epithelial cell migrationGO:001063420.031
endocrine system developmentGO:0035270650.031
extrinsic apoptotic signaling pathwayGO:009719130.031
nuclear transportGO:005116940.031
cellular component biogenesisGO:00440851780.031
reactive oxygen species biosynthetic processGO:190340910.031
negative regulation of immune responseGO:005077720.031
immune system developmentGO:00025201910.031
regulation of cell projection assemblyGO:006049140.031
tube morphogenesisGO:00352393490.031
negative regulation of striated muscle tissue developmentGO:004584320.031
regulation of muscle contractionGO:000693730.031
regulation of skeletal muscle fiber developmentGO:004874220.031
positive regulation of neuron deathGO:190121610.031
protein complex subunit organizationGO:0071822460.030
cellular protein modification processGO:00064641000.030
response to abiotic stimulusGO:00096281220.030
response to external biotic stimulusGO:0043207970.030
astrocyte differentiationGO:004870810.030
regulation of transcription dna templatedGO:00063552130.029
cell substrate junction assemblyGO:000704420.029
urogenital system developmentGO:0001655970.029
cell cycle g2 m phase transitionGO:004483940.029
regulation of cardiac muscle tissue developmentGO:005502410.029
regulation of ion transmembrane transporter activityGO:003241220.029
transcription dna templatedGO:00063511810.029
sensory organ morphogenesisGO:00905962000.029
phagocytosisGO:000690930.029
axon developmentGO:00615641660.029
inositol lipid mediated signalingGO:004801720.029
pronephros developmentGO:0048793690.029
heterocycle biosynthetic processGO:00181302150.029
response to vitaminGO:003327330.028
macromolecular complex subunit organizationGO:0043933740.028
regulation of blood circulationGO:1903522320.028
phosphorus metabolic processGO:00067931090.028
cellular response to starvationGO:000926710.028
multicellular organismal homeostasisGO:0048871290.028
stem cell proliferationGO:007208940.028
reactive nitrogen species metabolic processGO:200105700.028
meiotic cell cycle processGO:190304630.028
deathGO:00162651210.028
heart contractionGO:0060047710.028
embryonic skeletal system developmentGO:0048706970.027
regulation of mesenchymal cell proliferationGO:001046410.027
axonogenesisGO:00074091520.027
positive regulation of cellular processGO:00485222010.027
regulation of hematopoietic progenitor cell differentiationGO:190153210.027
gastrulationGO:00073692080.027
meiotic chromosome segregationGO:004513230.027
regulation of transmembrane transporter activityGO:002289820.026
digestive tract developmentGO:00485652650.026
positive regulation of cell deathGO:0010942290.026
gland developmentGO:00487321430.026
regulation of cytoplasmic transportGO:190364940.026
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathwayGO:0090101220.026
cell growthGO:0016049570.026
vasculature developmentGO:00019442780.026
tissue migrationGO:0090130370.026
regulation of vasculature developmentGO:1901342330.026
production of molecular mediator of immune responseGO:000244020.026
hormone secretionGO:004687920.026
cellular component assembly involved in morphogenesisGO:00109271070.026
hypothalamus cell differentiationGO:002197940.025
double strand break repairGO:000630230.025
cell part morphogenesisGO:00329902460.025
skeletal system developmentGO:00015011810.025
mesenchyme developmentGO:00604851270.025
response to organic cyclic compoundGO:0014070510.025
maintenance of locationGO:005123540.025
cardiac atrium developmentGO:000323040.025
nucleic acid templated transcriptionGO:00976591810.025
phosphatidylinositol 3 kinase signalingGO:001406520.025
spinal cord developmentGO:0021510460.024
regulation of calcium ion transportGO:005192420.024
mesenchymal cell proliferationGO:001046310.024
cellular protein metabolic processGO:00442671290.024
chemosensory behaviorGO:000763510.024
telomere organizationGO:003220010.024
regulation of bindingGO:005109830.024
neuron developmentGO:00486662620.024
regulation of stem cell differentiationGO:200073640.024
chemical homeostasisGO:0048878490.024
response to other organismGO:0051707970.024
regulation of cell matrix adhesionGO:000195210.024
single organism transportGO:00447652060.024
negative regulation of response to stimulusGO:00485851040.024
regulation of transporter activityGO:003240920.024
positive regulation of cytosolic calcium ion concentrationGO:000720440.024
growthGO:00400071740.023
embryonic skeletal system morphogenesisGO:0048704930.023
single organism membrane fusionGO:004480120.023
cell cycle g1 s phase transitionGO:004484310.023
cell projection assemblyGO:0030031640.023
g2 m transition of mitotic cell cycleGO:000008640.023
ion homeostasisGO:0050801410.023
positive regulation of cell adhesionGO:004578510.023
muscle cell developmentGO:00550011150.023
vasculogenesisGO:0001570410.023
amine metabolic processGO:000930820.023
response to hexoseGO:000974630.023
neuron projection developmentGO:00311751800.022
multicellular organismal metabolic processGO:004423620.022
camera type eye morphogenesisGO:00485931080.022
negative regulation of multicellular organismal processGO:0051241690.022
somatic muscle developmentGO:000752540.022
antimicrobial humoral responseGO:001973020.022
circulatory system processGO:0003013870.022
kidney vasculature developmentGO:006144020.022
locomotionGO:00400113130.022
regulation of heart growthGO:006042020.022
branchiomotor neuron axon guidanceGO:002178510.022
i kappab kinase nf kappab signalingGO:000724940.022
regulation of cell developmentGO:00602841000.022
cardiac atrium morphogenesisGO:000320920.022
regulation of cellular amino acid metabolic processGO:000652100.022
embryonic digestive tract developmentGO:004856640.022
cellular carbohydrate metabolic processGO:004426240.022
glomerulus vasculature developmentGO:007201220.021
regulation of stem cell proliferationGO:007209120.021
regulation of apoptotic processGO:0042981980.021
positive regulation of canonical wnt signaling pathwayGO:009026340.021
negative regulation of cellular catabolic processGO:003133030.021
neural retina developmentGO:0003407490.021
connective tissue developmentGO:0061448990.021
hepaticobiliary system developmentGO:0061008980.021
lateral line system developmentGO:0048925760.021
macromolecule modificationGO:00434121110.021
positive chemotaxisGO:005091850.021
regulation of rna biosynthetic processGO:20011412130.021
response to carbohydrateGO:000974330.021
developmental cell growthGO:0048588520.021
negative regulation of catabolic processGO:000989530.021
regulation of glial cell differentiationGO:004568540.020
positive regulation of map kinase activityGO:004340630.020
response to biotic stimulusGO:0009607970.020
cellular response to growth factor stimulusGO:0071363390.020
positive regulation of epithelial cell proliferationGO:005067910.020
striated muscle cell differentiationGO:00511461290.020
negative regulation of muscle tissue developmentGO:190186220.020
ovarian follicle developmentGO:000154120.020
ventricular cardiac muscle tissue developmentGO:000322930.020
negative regulation of rna biosynthetic processGO:1902679450.020
protein modification processGO:00362111000.020
positive regulation of response to stimulusGO:0048584800.020
epithelial tube morphogenesisGO:00605621480.020
peptidyl serine phosphorylationGO:001810510.020
regulation of cellular component organizationGO:0051128860.020
pathway restricted smad protein phosphorylationGO:006038910.020
negative regulation of cytokine productionGO:000181810.020
epithelium migrationGO:0090132250.020
ovulation cycleGO:004269820.020
protein secretionGO:000930610.019
circadian sleep wake cycle sleepGO:005080210.019
regulation of synaptic growth at neuromuscular junctionGO:000858210.019
regulation of reproductive processGO:200024140.019
embryonic cranial skeleton morphogenesisGO:0048701900.019
regulation of behaviorGO:0050795240.019
regulation of i kappab kinase nf kappab signalingGO:004312240.019
digestive tract morphogenesisGO:00485462310.019
regulation of bmp signaling pathwayGO:0030510390.019
notochord developmentGO:0030903540.019
ovulation cycle processGO:002260220.019
phosphorylationGO:0016310690.019
programmed cell deathGO:00125011190.019
negative regulation of nitrogen compound metabolic processGO:0051172590.019
regulation of anatomical structure morphogenesisGO:00226031300.019
eye morphogenesisGO:00485921440.019
b cell differentiationGO:003018310.019
phosphate containing compound metabolic processGO:00067961080.019
cardiac cell fate commitmentGO:006091110.019
regulation of cellular amine metabolic processGO:003323800.019
membrane fusionGO:006102520.019
transmembrane transportGO:00550851200.019
regulation of cellular ketone metabolic processGO:001056570.019
fin developmentGO:0033333770.018
cell morphogenesis involved in differentiationGO:00009041950.018
circadian sleep wake cycleGO:004274520.018
negative regulation of sequence specific dna binding transcription factor activityGO:004343320.018
negative regulation of biological processGO:00485193040.018
glomerulus developmentGO:0032835270.018
autophagyGO:000691440.018
g protein coupled receptor signaling pathwayGO:0007186740.018
cell junction organizationGO:0034330110.018
regulation of protein modification by small protein conjugation or removalGO:190332030.018
negative regulation of dna metabolic processGO:005105340.018
positive regulation of cytokine productionGO:000181920.018
stem cell divisionGO:001714510.018
organonitrogen compound metabolic processGO:1901564740.018
odontogenesis of dentin containing toothGO:004247510.018
regulation of signal transductionGO:00099662250.018
regulation of multicellular organism growthGO:004001440.018
response to nutrientGO:000758430.018
regulation of organ growthGO:004662030.018
dna catabolic processGO:000630810.018
regulation of epithelial to mesenchymal transitionGO:001071730.017
oocyte maturationGO:000155640.017
cellular amine metabolic processGO:004410620.017
cell projection morphogenesisGO:00488582440.017
cell proliferationGO:0008283800.017
positive regulation of i kappab kinase nf kappab signalingGO:004312330.017
regulation of signalingGO:00230512350.017
biological adhesionGO:0022610400.017
negative regulation of cell deathGO:0060548600.017
septum transversum developmentGO:000334340.017
positive regulation of nucleobase containing compound metabolic processGO:0045935690.017
multicellular organism growthGO:003526440.017
negative regulation of map kinase activityGO:004340720.017
mesenchymal cell differentiationGO:0048762870.017
mitotic cell cycle processGO:1903047480.017
telomere maintenanceGO:000072310.017
peptidyl lysine acetylationGO:001839420.017
regulation of circadian sleep wake cycleGO:004274910.017
negative regulation of signalingGO:0023057960.017
digestive system developmentGO:00551232890.017
regulation of circadian rhythmGO:004275240.017
regulation of endothelial cell proliferationGO:000193610.017
signal transduction in absence of ligandGO:003803410.017
convergent extensionGO:00600261180.017
cranial suture morphogenesisGO:006036310.017
regulation of tube sizeGO:003515020.017
wnt signaling pathwayGO:0016055800.017
hematopoietic stem cell differentiationGO:0060218200.017
mesenchymal cell developmentGO:0014031780.016
regulation of synapse assemblyGO:005196330.016
positive regulation of mesenchymal cell proliferationGO:000205310.016
central nervous system neuron differentiationGO:0021953740.016
gland morphogenesisGO:0022612130.016
cellular component movementGO:00069283350.016
muscle tissue developmentGO:00605371100.016
regulation of circadian sleep wake cycle sleepGO:004518710.016
adherens junction assemblyGO:003433310.016
adult behaviorGO:003053420.016
sprouting angiogenesisGO:0002040530.016
positive regulation of cellular amine metabolic processGO:003324000.016
cardiac chamber formationGO:000320740.016
meiosis iGO:000712710.016
blood vessel endothelial cell migrationGO:0043534180.016
gtp catabolic processGO:000618420.016
negative regulation of secretion by cellGO:190353120.016
osteoclast differentiationGO:003031610.016
regulation of neuronal synaptic plasticityGO:004816810.016
regulation of cell differentiationGO:00455951420.016
anterior posterior pattern specificationGO:00099521520.016
negative regulation of dna replicationGO:000815620.016
negative regulation of protein phosphorylationGO:000193340.016
inner ear developmentGO:00488391260.016
sensory perception of smellGO:000760820.016
cranial nerve developmentGO:0021545420.016
striated muscle tissue developmentGO:00147061100.016
cellular response to vascular endothelial growth factor stimulusGO:003592430.016
guanosine containing compound catabolic processGO:190106920.016
regulation of protein complex assemblyGO:004325430.015
actin cytoskeleton organizationGO:0030036630.015
positive regulation of apoptotic signaling pathwayGO:200123510.015
calcium ion homeostasisGO:0055074190.015
myeloid leukocyte migrationGO:0097529120.015
developmental growth involved in morphogenesisGO:0060560860.015
exocrine system developmentGO:0035272280.015
cell motilityGO:00488702440.015
canonical wnt signaling pathwayGO:0060070480.015
positive regulation of neuron apoptotic processGO:004352510.015
cell agingGO:000756920.015
determination of heart left right asymmetryGO:00613711170.015
peptidyl serine modificationGO:001820920.015
response to monosaccharideGO:003428430.015
amino acid transportGO:000686520.015
positive regulation of dna metabolic processGO:005105410.015
cellular ketone metabolic processGO:0042180110.015
embryonic heart tube developmentGO:00350501330.015
nerve developmentGO:0021675450.015
positive regulation of cellular amino acid metabolic processGO:004576400.015
negative regulation of i kappab kinase nf kappab signalingGO:004312410.015
negative regulation of macromolecule biosynthetic processGO:0010558480.015
regulation of sodium ion transportGO:000202820.015
regulation of blood vessel sizeGO:005088020.015
negative regulation of mapk cascadeGO:004340940.015
positive regulation of metabolic processGO:00098931080.015
regulation of angiogenesisGO:0045765260.015
regulation of heart contractionGO:0008016320.015
positive regulation of peptidyl tyrosine phosphorylationGO:005073110.015
stem cell maintenanceGO:001982740.015
chemotaxisGO:00069351040.014
immune responseGO:0006955280.014
positive regulation of nitrogen compound metabolic processGO:0051173690.014
cellular response to stressGO:0033554620.014
muscle structure developmentGO:00610611960.014
negative regulation of chemotaxisGO:005092240.014
regulation of synapse organizationGO:005080730.014
smooth muscle contractionGO:000693920.014
heart processGO:0003015710.014
lymph vessel developmentGO:0001945270.014
nephron morphogenesisGO:007202820.014
negative regulation of secretionGO:005104820.014
blood circulationGO:0008015870.014
inorganic ion transmembrane transportGO:0098660570.014
glial cell migrationGO:000834730.014
double strand break repair via homologous recombinationGO:000072410.014
positive regulation of secretion by cellGO:190353210.014
intracellular signal transductionGO:0035556850.014
protein homooligomerizationGO:005126030.014
epithelial to mesenchymal transitionGO:0001837210.014
actomyosin structure organizationGO:0031032530.014
embryonic hemopoiesisGO:0035162530.014
epithelial cell differentiationGO:00308551160.014
pectoral fin developmentGO:0033339500.014
hormone transportGO:000991420.014
cation transmembrane transportGO:0098655650.014
regulation of phosphate metabolic processGO:0019220430.014
somite developmentGO:0061053960.014
regulation of peptidyl tyrosine phosphorylationGO:005073010.014
myeloid cell developmentGO:0061515320.014
positive regulation of cell cycleGO:004578730.014
lymphangiogenesisGO:0001946250.014
cellular component disassemblyGO:002241110.014
specification of symmetryGO:00097992040.014
epithelial cell migrationGO:0010631250.013
cell fate commitmentGO:0045165990.013
negative regulation of protein kinase activityGO:000646940.013
larval heart developmentGO:000750820.013
response to steroid hormoneGO:0048545350.013
cytoskeleton organizationGO:0007010960.013
regulation of developmental processGO:00507932470.013
mononuclear cell proliferationGO:003294310.013
embryonic heart tube morphogenesisGO:00031431080.013
renal system vasculature developmentGO:006143720.013
negative regulation of macromolecule metabolic processGO:0010605760.013
atrioventricular valve developmentGO:0003171110.013
diencephalon developmentGO:0021536580.013
negative regulation of biosynthetic processGO:0009890550.013
positive regulation of cellular metabolic processGO:0031325940.013
negative regulation of protein serine threonine kinase activityGO:007190120.013
negative regulation of nucleobase containing compound metabolic processGO:0045934590.013
regulation of neural precursor cell proliferationGO:200017730.013
lipid homeostasisGO:005508830.013

ptpn21 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.057
muscular diseaseDOID:008000000.045
musculoskeletal system diseaseDOID:1700.045
muscle tissue diseaseDOID:6600.045
myopathyDOID:42300.045
cardiovascular system diseaseDOID:128700.020
heart diseaseDOID:11400.020
intrinsic cardiomyopathyDOID:006003600.020
cardiomyopathyDOID:005070000.020
disease of cellular proliferationDOID:1456600.019