Danio rerio

30 known processes

irx3b

iroquois homeobox protein 3b

(Aliases: ziro3b,zgc:76885,wu:fb36a07)

irx3b biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
central nervous system developmentGO:00074173870.756
rhombomere 5 morphogenesisGO:002166410.720
brain developmentGO:00074202930.661
neuron neuron synaptic transmissionGO:000727010.594
head developmentGO:00603223030.594
sensory organ developmentGO:00074233930.548
rhombomere boundary formationGO:0021654100.498
regulation of cellular metabolic processGO:00313233200.448
lymph vessel morphogenesisGO:0036303250.440
synaptic transmissionGO:0007268350.412
rhombomere developmentGO:0021546190.405
cellular macromolecule biosynthetic processGO:00346452240.392
anatomical structure arrangementGO:004853220.381
cellular component movementGO:00069283350.367
transportGO:00068102200.364
dendrite guidanceGO:007098300.352
regulation of nitrogen compound metabolic processGO:00511712510.351
facial nerve morphogenesisGO:002161010.335
stem cell fate commitmentGO:004886510.325
neuron projection developmentGO:00311751800.294
epithelial cell differentiationGO:00308551160.294
nucleobase containing compound biosynthetic processGO:00346542050.277
rhombomere morphogenesisGO:0021593170.276
positive regulation of biological processGO:00485182530.275
neuron differentiationGO:00301823530.270
facial nerve developmentGO:002156130.267
hair cell differentiationGO:0035315320.260
angioblast cell migration involved in selective angioblast sproutingGO:003547540.258
peripheral nervous system neuron differentiationGO:0048934280.249
transcription dna templatedGO:00063511810.244
regulation of multicellular organismal processGO:00512392770.242
heterocycle biosynthetic processGO:00181302150.234
larval developmentGO:000216420.232
axonogenesisGO:00074091520.215
organic substance biosynthetic processGO:19015762890.203
regulation of transcription dna templatedGO:00063552130.203
establishment of localizationGO:00512342440.201
apoptotic process involved in developmentGO:190274220.200
rhombomere 5 developmentGO:002157140.195
cellular component morphogenesisGO:00329893360.193
wnt signaling pathwayGO:0016055800.192
positive regulation of cellular processGO:00485222010.192
regulation of wnt signaling pathwayGO:0030111530.191
detection of temperature stimulusGO:001604800.188
cellular biosynthetic processGO:00442492860.177
endothelial cell fate commitmentGO:006083930.174
epidermis developmentGO:0008544480.174
signal transductionGO:00071654550.172
regulation of cell developmentGO:00602841000.169
negative regulation of axon regenerationGO:004868140.164
regulation of primary metabolic processGO:00800903110.164
embryonic organ developmentGO:00485683810.160
extracellular structure organizationGO:0043062270.159
negative regulation of cellular processGO:00485232830.155
synaptic transmission cholinergicGO:000727140.154
negative regulation of nitrogen compound metabolic processGO:0051172590.150
regulation of biosynthetic processGO:00098892500.150
hormone transportGO:000991420.147
positive regulation of gene expressionGO:0010628710.146
regulation of endodermal cell differentiationGO:1903224150.146
midbrain hindbrain boundary developmentGO:0030917230.132
transcription from rna polymerase iii promoterGO:000638310.130
macromolecule biosynthetic processGO:00090592270.126
negative regulation of neuron projection regenerationGO:007057140.123
developmental programmed cell deathGO:001062340.123
regulation of endodermal cell fate specificationGO:0042663150.122
agingGO:000756820.120
negative regulation of biological processGO:00485193040.118
cell morphogenesis involved in differentiationGO:00009041950.118
regulation of cell fate commitmentGO:0010453220.113
digestive system developmentGO:00551232890.112
cell fate specificationGO:0001708680.111
ectoderm developmentGO:000739890.109
lymphatic endothelial cell fate commitmentGO:006083810.109
cellular nitrogen compound metabolic processGO:00346412900.109
regulation of gastrulationGO:0010470240.106
rna metabolic processGO:00160702190.100
regulation of syncytium formation by plasma membrane fusionGO:006014220.100
regulation of transcription from rna polymerase iii promoterGO:000635910.099
maintenance of locationGO:005123540.097
cell part morphogenesisGO:00329902460.097
negative regulation of collateral sproutingGO:004867120.097
positive regulation of cellular component biogenesisGO:004408930.094
aromatic compound biosynthetic processGO:00194382170.093
regulation of cell differentiationGO:00455951420.092
response to chemicalGO:00422213200.089
neuromast mantle cell differentiationGO:004888810.088
regulation of embryonic developmentGO:0045995470.088
hindbrain developmentGO:0030902910.085
regulation of nervous system developmentGO:0051960900.083
regulation of rna biosynthetic processGO:20011412130.080
negative regulation of cell developmentGO:0010721260.078
hemopoiesisGO:00300971830.076
embryonic organ morphogenesisGO:00485622740.076
cell projection organizationGO:00300302840.076
regulation of rna metabolic processGO:00512522240.075
negative regulation of nucleobase containing compound metabolic processGO:0045934590.075
sensory system developmentGO:0048880760.075
regulation of nucleic acid templated transcriptionGO:19035062130.074
fin regenerationGO:0031101510.071
rhombomere formationGO:0021594120.071
peptide transportGO:001583310.070
adult behaviorGO:003053420.068
regulation of collateral sprouting of intact axon in response to injuryGO:004868320.067
regulation of cellular macromolecule biosynthetic processGO:20001122220.067
anterior posterior pattern specificationGO:00099521520.067
nucleic acid templated transcriptionGO:00976591810.067
generation of neuronsGO:00486993850.066
gene expressionGO:00104672520.065
ear developmentGO:00435831270.062
cellular macromolecule metabolic processGO:00442603910.061
organic substance transportGO:0071702580.061
cellular nitrogen compound biosynthetic processGO:00442712180.061
regulation of cell communicationGO:00106462320.060
glomerular visceral epithelial cell fate commitmentGO:007214940.060
regulation of multicellular organismal developmentGO:20000262230.060
cell surface receptor signaling pathwayGO:00071663250.059
hematopoietic or lymphoid organ developmentGO:00485341910.059
negative regulation of chemotaxisGO:005092240.059
regulation of cell projection organizationGO:0031344440.059
epidermal cell differentiationGO:0009913360.059
negative regulation of nucleic acid templated transcriptionGO:1903507450.058
lymphatic endothelial cell differentiationGO:006083610.057
mechanosensory lateral line system developmentGO:0048881490.056
cellular component assemblyGO:00226071700.056
regulation of neuron differentiationGO:0045664560.056
adherens junction organizationGO:003433240.056
negative regulation of collateral sprouting of intact axon in response to injuryGO:004868520.055
cell cell signalingGO:0007267520.054
regulation of anatomical structure morphogenesisGO:00226031300.053
cellular localizationGO:0051641970.053
immune system processGO:00023762410.051
lateral line system developmentGO:0048925760.051
locomotionGO:00400113130.051
lymphangiogenesisGO:0001946250.050
convergent extensionGO:00600261180.050
negative regulation of metabolic processGO:0009892860.049
dna templated transcription initiationGO:000635210.049
positive regulation of metabolic processGO:00098931080.049
forebrain developmentGO:0030900960.049
regulation of neurogenesisGO:0050767870.048
transcription from rna polymerase ii promoterGO:0006366800.048
single organism localizationGO:19025782250.047
regulation of dendrite morphogenesisGO:004881430.047
regulation of stem cell differentiationGO:200073640.046
sensory neuron axon guidanceGO:009737430.046
single organism metabolic processGO:00447102170.046
nucleic acid metabolic processGO:00903042440.045
embryonic cranial skeleton morphogenesisGO:0048701900.045
lymph vessel developmentGO:0001945270.045
regulation of organ growthGO:004662030.045
segment polarity determinationGO:000736710.045
inorganic cation transmembrane transportGO:0098662500.044
negative regulation of protein kinase activityGO:000646940.043
skin developmentGO:0043588540.042
regulation of cellular biosynthetic processGO:00313262450.042
regulation of metabolic processGO:00192223590.042
regulation of gene expressionGO:00104682650.042
morphogenesis of embryonic epitheliumGO:0016331300.041
glomerular epithelial cell fate commitmentGO:007231440.041
negative regulation of macromolecule biosynthetic processGO:0010558480.041
regulation of protein transportGO:005122330.041
regulation of macromolecule metabolic processGO:00602553170.041
regulation of nucleobase containing compound metabolic processGO:00192192500.041
neuron developmentGO:00486662620.040
cellular response to retinoic acidGO:007130010.040
chordate embryonic developmentGO:00430092710.040
regulation of erk1 and erk2 cascadeGO:007037240.039
heterocycle metabolic processGO:00464832900.039
endodermal cell differentiationGO:0035987190.039
cation transportGO:0006812810.039
rhombomere 6 developmentGO:002157240.039
regulation of developmental processGO:00507932470.038
negative regulation of axon guidanceGO:190266810.038
single organism transportGO:00447652060.038
cell morphogenesis involved in neuron differentiationGO:00486671630.038
receptor internalizationGO:003162320.037
digestive tract morphogenesisGO:00485462310.037
blood vessel developmentGO:00015682460.036
embryonic skeletal system morphogenesisGO:0048704930.035
retinoic acid receptor signaling pathwayGO:0048384160.035
actomyosin structure organizationGO:0031032530.034
phagocytosisGO:000690930.034
negative regulation of gene expressionGO:0010629650.034
hormone secretionGO:004687920.033
positive regulation of rna biosynthetic processGO:1902680570.033
female sex differentiationGO:004666040.033
tissue migrationGO:0090130370.033
vasculature developmentGO:00019442780.033
nephron developmentGO:0072006310.033
regulation of cell fate specificationGO:0042659200.032
olfactory bulb axon guidanceGO:007167830.032
segmentationGO:0035282970.032
regulation of dna methylationGO:004403050.032
lipid storageGO:001991510.032
central nervous system neuron differentiationGO:0021953740.032
positive regulation of transcription dna templatedGO:0045893570.031
negative regulation of transcription dna templatedGO:0045892450.031
cellular protein modification processGO:00064641000.031
cellular component assembly involved in morphogenesisGO:00109271070.030
ion transmembrane transportGO:0034220910.030
cellular amine metabolic processGO:004410620.030
protein secretionGO:000930610.030
positive regulation of cellular biosynthetic processGO:0031328680.029
methylationGO:0032259220.028
organic cyclic compound biosynthetic processGO:19013622230.028
response to carbohydrateGO:000974330.028
cell projection morphogenesisGO:00488582440.028
gastrulationGO:00073692080.028
negative regulation of mitosisGO:004583930.028
positive regulation of axon guidanceGO:190266910.028
branching morphogenesis of an epithelial tubeGO:0048754150.028
negative regulation of granulocyte chemotaxisGO:007162330.027
nitrogen compound metabolic processGO:00068073190.027
negative regulation of epithelial cell migrationGO:001063310.027
ion transportGO:00068111140.027
carbon dioxide transportGO:001567030.026
rostrocaudal neural tube patterningGO:0021903290.026
posterior lateral line nerve glial cell morphogenesis involved in differentiationGO:004894250.026
regulation of dendrite developmentGO:005077330.026
pronephric nephron developmentGO:0039019140.025
organic cyclic compound metabolic processGO:19013603010.025
hindbrain morphogenesisGO:0021575220.025
wound healingGO:0042060900.025
regulation of neurological system processGO:003164420.025
response to light stimulusGO:0009416460.025
protein modification processGO:00362111000.025
embryonic digestive tract morphogenesisGO:004855730.025
positive regulation of macromolecule biosynthetic processGO:0010557590.025
regulation of establishment of protein localizationGO:007020140.025
negative regulation of map kinase activityGO:004340720.025
central nervous system neuron developmentGO:0021954290.025
glial cell developmentGO:0021782200.025
inner ear morphogenesisGO:0042472630.025
kidney developmentGO:0001822920.025
regulation of cell morphogenesis involved in differentiationGO:0010769380.024
collateral sprouting of intact axon in response to injuryGO:004867320.024
muscle cell developmentGO:00550011150.024
negative regulation of cellular biosynthetic processGO:0031327550.024
positive regulation of macromolecule metabolic processGO:0010604930.024
cell morphogenesisGO:00009022890.023
negative chemotaxisGO:005091910.023
response to external stimulusGO:00096052640.023
posterior lateral line nerve glial cell differentiationGO:004893150.023
embryonic viscerocranium morphogenesisGO:0048703520.023
immune system developmentGO:00025201910.023
modification dependent protein catabolic processGO:001994130.023
angiogenesisGO:00015251580.023
skeletal system morphogenesisGO:00487051020.023
negative regulation of signal transductionGO:0009968940.023
negative regulation of stem cell differentiationGO:200073720.023
intrahepatic bile duct developmentGO:0035622110.023
tube morphogenesisGO:00352393490.023
positive regulation of gastrulationGO:200054320.023
motor neuron axon guidanceGO:0008045230.022
production of molecular mediator of immune responseGO:000244020.022
angioblast cell migrationGO:003547690.022
stem cell differentiationGO:00488631170.022
regulation of transcription from rna polymerase ii promoterGO:00063571140.022
oocyte maturationGO:000155640.022
negative regulation of mapk cascadeGO:004340940.022
cellular aromatic compound metabolic processGO:00067252950.022
epithelial cell fate commitmentGO:0072148110.022
positive regulation of cellular metabolic processGO:0031325940.022
neuron projection guidanceGO:0097485860.022
positive regulation of biosynthetic processGO:0009891680.022
negative regulation of developmental processGO:0051093650.021
positive regulation of muscle tissue developmentGO:190186310.021
biosynthetic processGO:00090582940.021
peripheral nervous system neuron axonogenesisGO:0048936130.020
nerve developmentGO:0021675450.020
formation of anatomical boundaryGO:0048859140.020
dorsal spinal cord developmentGO:002151610.020
positive regulation of nucleic acid templated transcriptionGO:1903508570.020
positive regulation of nucleobase containing compound metabolic processGO:0045935690.020
secondary metabolic processGO:001974830.020
regulation of cellular ketone metabolic processGO:001056570.020
negative regulation of cellular metabolic processGO:0031324770.020
cell substrate adhesionGO:003158940.020
branching morphogenesis of a nerveGO:004875540.020
cartilage developmentGO:0051216960.019
axon ensheathment in central nervous systemGO:003229120.019
appendage developmentGO:0048736800.019
embryonic limb morphogenesisGO:003032620.019
regulation of signalingGO:00230512350.019
response to vitamin b3GO:003355220.019
cellular lipid metabolic processGO:0044255360.019
mesoderm formationGO:0001707430.019
regulation of photoreceptor cell differentiationGO:004653220.019
hypothalamus developmentGO:0021854140.019
deathGO:00162651210.019
astrocyte differentiationGO:004870810.019
sodium ion transportGO:0006814240.019
negative regulation of signalingGO:0023057960.019
multicellular organismal signalingGO:0035637220.019
negative regulation of biosynthetic processGO:0009890550.019
cell cell recognitionGO:000998810.018
retinoic acid metabolic processGO:004257390.018
embryonic digestive tract developmentGO:004856640.018
central nervous system segmentationGO:003528360.018
cell proliferation in forebrainGO:002184630.018
endodermal cell fate commitmentGO:0001711180.018
regulation of intracellular protein transportGO:003315730.018
rhombomere 4 morphogenesisGO:002166150.018
regulation of fatty acid metabolic processGO:001921710.018
negative regulation of macromolecule metabolic processGO:0010605760.018
blood vessel endothelial cell migrationGO:0043534180.018
negative regulation of rna metabolic processGO:0051253480.018
regulation of cell morphogenesisGO:0022604420.018
regulation of cellular amine metabolic processGO:003323800.018
neuroblast differentiationGO:001401610.018
negative regulation of cell migrationGO:0030336170.018
monovalent inorganic cation transportGO:0015672420.018
growthGO:00400071740.018
erk1 and erk2 cascadeGO:007037140.017
growth plate cartilage developmentGO:000341720.017
female gonad developmentGO:000858540.017
regulation of neuronal synaptic plasticityGO:004816810.017
otolith morphogenesisGO:003247480.017
regulation of phGO:000688530.017
oxoacid metabolic processGO:0043436310.017
response to hexoseGO:000974630.017
cell fate commitmentGO:0045165990.017
response to monosaccharideGO:003428430.017
commissural neuron axon guidanceGO:007167930.017
embryonic appendage morphogenesisGO:0035113300.016
regulation of skeletal muscle fiber developmentGO:004874220.016
negative regulation of locomotionGO:0040013180.016
regulation of neuron projection developmentGO:0010975400.016
cellular component biogenesisGO:00440851780.016
nucleobase containing compound metabolic processGO:00061392740.016
oligopeptide transportGO:000685710.016
cytoskeleton dependent cytokinesisGO:006164030.016
negative regulation of response to stimulusGO:00485851040.016
rna biosynthetic processGO:00327741810.016
melanin metabolic processGO:000658220.016
organelle assemblyGO:00709251100.016
developmental growth involved in morphogenesisGO:0060560860.016
cell motilityGO:00488702440.016
regulation of myotube differentiationGO:001083020.016
epithelial cell morphogenesisGO:000338220.016
branchiomotor neuron axon guidanceGO:002178510.016
negative regulation of cell morphogenesis involved in differentiationGO:001077180.015
sodium ion transmembrane transportGO:0035725210.015
regulation of neuron projection regenerationGO:007057070.015
response to glucoseGO:000974930.015
protein targeting to membraneGO:000661210.015
negative regulation of protein phosphorylationGO:000193340.015
regulation of biological qualityGO:00650082630.015
neuroblast fate commitmentGO:001401710.015
embryonic skeletal system developmentGO:0048706970.015
synaptic target recognitionGO:000803910.015
cellular ketone metabolic processGO:0042180110.015
negative regulation of reproductive processGO:200024230.015
response to organic substanceGO:00100331530.015
morphogenesis of a branching structureGO:0001763210.015
regulation of filopodium assemblyGO:005148920.015
positive regulation of axon extension involved in axon guidanceGO:004884210.015
diencephalon developmentGO:0021536580.015
posterior lateral line neuromast mantle cell differentiationGO:004892410.015
common bile duct developmentGO:0061009130.015
negative regulation of protein serine threonine kinase activityGO:007190120.015
regulation of signal transductionGO:00099662250.015
spinal cord developmentGO:0021510460.015
tube closureGO:006060610.014
lateral line developmentGO:0048882660.014
blood vessel morphogenesisGO:00485142160.014
dendrite developmentGO:001635890.014
regulation of cell activationGO:005086510.014
midbrain developmentGO:0030901280.014
monoamine transportGO:001584410.014
intracellular receptor signaling pathwayGO:0030522300.014
regulation of protein complex assemblyGO:004325430.014
regulation of cell projection assemblyGO:006049140.014
positive regulation of striated muscle cell differentiationGO:005115510.014
somatic muscle developmentGO:000752540.014
posterior lateral line system developmentGO:0048915460.014
cellular response to oxygen levelsGO:007145310.013
hypotonic salinity responseGO:004253950.013
ear morphogenesisGO:0042471640.013
positive regulation of rna metabolic processGO:0051254590.013
epithelial cell proliferationGO:0050673170.013
nitrogen compound transportGO:0071705230.013
distal tubule developmentGO:007201710.013
negative regulation of cell motilityGO:2000146170.013
wnt signaling pathway involved in digestive tract morphogenesisGO:004433340.013
regulation of reproductive processGO:200024140.013
neural tube developmentGO:0021915620.013
chloride transportGO:000682180.013
renal absorptionGO:007029310.013
axon developmentGO:00615641660.013
pronephric nephron tubule developmentGO:003902020.013
otic vesicle developmentGO:0071599420.013
cell migrationGO:00164772370.013
myofibril assemblyGO:0030239480.013
response to oxygen containing compoundGO:1901700550.013
regulation of protein import into nucleusGO:004230620.013
regulation of cellular component organizationGO:0051128860.013
sodium ion importGO:009736930.013
digestive tract developmentGO:00485652650.013
embryo development ending in birth or egg hatchingGO:00097922710.013
negative regulation of axon extension involved in axon guidanceGO:004884310.013
dorsal ventral pattern formationGO:00099531250.013
metal ion transportGO:0030001580.013
regulation of peptidyl tyrosine phosphorylationGO:005073010.013
stem cell proliferationGO:007208940.012
brain segmentationGO:003528460.012
positive regulation of secretionGO:005104710.012
auditory receptor cell morphogenesisGO:000209340.012
macromolecule modificationGO:00434121110.012
nucleocytoplasmic transportGO:000691340.012
gas transportGO:001566930.012
regulation of cytoplasmic transportGO:190364940.012
single organism reproductive processGO:0044702400.012
protein metabolic processGO:00195381830.012
endocytosisGO:0006897160.012
bicarbonate transportGO:001570140.012
entrainment of circadian clock by photoperiodGO:004315310.012
mechanoreceptor differentiationGO:0042490370.012
ossificationGO:0001503230.012
negative regulation of rna biosynthetic processGO:1902679450.012
cellular lipid catabolic processGO:004424230.012
regulation of glial cell differentiationGO:004568540.012
positive regulation of cytoskeleton organizationGO:005149530.012
inositol lipid mediated signalingGO:004801720.012
regulation of wnt signaling pathway planar cell polarity pathwayGO:200009520.011
negative regulation of axon extensionGO:003051770.011
endodermal cell fate determinationGO:000749320.011
response to amphetamineGO:000197510.011
trabecula formationGO:006034320.011
chemosensory behaviorGO:000763510.011
nephron morphogenesisGO:007202820.011
positive regulation of muscle cell differentiationGO:005114910.011
positive regulation of nitrogen compound metabolic processGO:0051173690.011
embryonic pattern specificationGO:0009880440.011
axis elongationGO:0003401310.011
positive regulation of cellular amine metabolic processGO:003324000.011
histone h3 k4 methylationGO:005156820.011
carbohydrate derivative biosynthetic processGO:1901137430.011
response to radiationGO:0009314510.011
wnt signaling pathway planar cell polarity pathwayGO:006007140.011
negative regulation of protein transportGO:005122430.011
response to vitaminGO:003327330.011
amine metabolic processGO:000930820.011
axon guidanceGO:0007411860.011
cellular response to chemical stimulusGO:00708871570.011
negative regulation of cellular component movementGO:0051271180.011
positive regulation of transportGO:005105020.011
cellular response to nutrient levelsGO:003166920.011
regulation of planar cell polarity pathway involved in axis elongationGO:200004010.011
localization of cellGO:00516742440.011
macromolecule methylationGO:0043414190.011
fin morphogenesisGO:0033334530.011
negative regulation of multicellular organismal processGO:0051241690.011
cellular response to decreased oxygen levelsGO:003629410.010
regulation of tube sizeGO:003515020.010
regulation of transmembrane transporter activityGO:002289820.010
phosphatidylinositol 3 kinase signalingGO:001406520.010
liver morphogenesisGO:007257680.010
lateral line nerve glial cell morphogenesis involved in differentiationGO:004893850.010
dendrite morphogenesisGO:004881350.010
urogenital system developmentGO:0001655970.010
response to lipidGO:0033993600.010
sympathetic ganglion developmentGO:006154920.010
negative regulation of nervous system developmentGO:0051961220.010
type b pancreatic cell differentiationGO:000330980.010

irx3b disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
neuromuscular diseaseDOID:44000.155
neuropathyDOID:87000.155
nervous system diseaseDOID:86300.155
disease of anatomical entityDOID:700.155
charcot marie tooth disease type 4DOID:005054100.155
charcot marie tooth diseaseDOID:1059500.155
urinary system cancerDOID:399600.093
cancerDOID:16200.093
disease of cellular proliferationDOID:1456600.093
organ system cancerDOID:005068600.093
type 2 diabetes mellitusDOID:935200.055
disease of metabolismDOID:001466700.055
diabetes mellitusDOID:935100.055
glucose metabolism diseaseDOID:419400.055
acquired metabolic diseaseDOID:006015800.055
carbohydrate metabolism diseaseDOID:005001300.055
maturity onset diabetes of the youngDOID:005052400.043
musculoskeletal system cancerDOID:006010000.026