Danio rerio

24 known processes

map2k4b

mitogen-activated protein kinase kinase 4b

(Aliases: zgc:194486,MKK4B)

map2k4b biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
epithelial cell proliferation involved in liver morphogenesisGO:007257520.240
anterior head developmentGO:009706520.239
wnt signaling pathway involved in digestive tract morphogenesisGO:004433340.238
regulation of wnt signaling pathway involved in digestive tract morphogenesisGO:200005620.233
thrombocyte differentiationGO:000257440.210
somitogenesisGO:0001756870.197
meiotic nuclear divisionGO:000712640.179
mediolateral intercalationGO:006003130.175
positive regulation of stress activated protein kinase signaling cascadeGO:007030430.170
proteolysis involved in cellular protein catabolic processGO:005160330.162
gene expressionGO:00104672520.161
determination of bilateral symmetryGO:00098552040.154
determination of dorsal ventral asymmetryGO:0048262340.153
hepatocyte proliferationGO:007257420.152
positive regulation of canonical wnt signaling pathwayGO:009026340.152
chordate embryonic developmentGO:00430092710.148
regulation of wnt signaling pathway calcium modulating pathwayGO:000859130.146
optic placode formationGO:000174340.144
cellular macromolecule metabolic processGO:00442603910.141
somite developmentGO:0061053960.141
spinal cord anterior posterior patterningGO:002151210.136
dorsal ventral pattern formationGO:00099531250.135
hepatic duct developmentGO:006101120.133
optic placode formation involved in camera type eye formationGO:004661930.131
negative regulation of anterior neural cell fate commitment of the neural plateGO:002200110.129
convergent extension involved in gastrulationGO:0060027710.128
tube morphogenesisGO:00352393490.123
cellular nitrogen compound metabolic processGO:00346412900.121
regulation of anterior head developmentGO:200074220.116
secondary metabolic processGO:001974830.116
modification dependent protein catabolic processGO:001994130.114
regulation of metabolic processGO:00192223590.112
negative regulation of nuclear divisionGO:005178430.110
negative regulation of anterior neural cell fate commitment of the neural plate by wnt signaling pathwayGO:002200210.110
lamellipodium organizationGO:009758110.109
response to transition metal nanoparticleGO:1990267280.109
gall bladder developmentGO:006101010.108
larval developmentGO:000216420.108
positive regulation of cellular catabolic processGO:003133130.106
immune system processGO:00023762410.104
determination of left right symmetryGO:00073681790.103
regulation of gene expressionGO:00104682650.103
nitrogen compound metabolic processGO:00068073190.099
positive regulation of catabolic processGO:000989640.099
proteasome mediated ubiquitin dependent protein catabolic processGO:004316120.094
positive regulation of jun kinase activityGO:004350720.092
phagocytosisGO:000690930.091
cytoskeleton organizationGO:0007010960.090
positive regulation of jnk cascadeGO:004633030.089
cellular macromolecule biosynthetic processGO:00346452240.086
regionalizationGO:00030022740.086
negative regulation of mitosisGO:004583930.086
embryonic heart tube developmentGO:00350501330.085
calcium ion transport into cytosolGO:006040230.085
regulation of macromolecule metabolic processGO:00602553170.085
cellular response to external stimulusGO:007149620.084
nuclear divisionGO:0000280230.084
hemopoiesisGO:00300971830.082
heterocycle metabolic processGO:00464832900.081
positive regulation of stress activated mapk cascadeGO:003287430.078
response to carbohydrateGO:000974330.078
specification of symmetryGO:00097992040.078
regulation of cellular metabolic processGO:00313233200.078
organelle organizationGO:00069962270.077
agingGO:000756820.077
organic cyclic compound metabolic processGO:19013603010.077
muscle cell differentiationGO:00426921390.077
proteasomal protein catabolic processGO:001049820.077
anterior posterior pattern specificationGO:00099521520.077
microtubule based processGO:0007017600.076
single organism localizationGO:19025782250.076
single organism transportGO:00447652060.076
negative regulation of sequestering of calcium ionGO:005128340.075
cytokinesisGO:000091030.075
segmentationGO:0035282970.074
regulation of protein catabolic processGO:004217610.074
guanosine containing compound catabolic processGO:190106920.073
cellular protein catabolic processGO:004425740.073
establishment of localizationGO:00512342440.072
macromolecule biosynthetic processGO:00090592270.072
cellular aromatic compound metabolic processGO:00067252950.071
regulation of biological qualityGO:00650082630.071
ubiquitin dependent protein catabolic processGO:000651130.070
regulation of mrna processingGO:005068430.070
heterocycle biosynthetic processGO:00181302150.069
embryo development ending in birth or egg hatchingGO:00097922710.068
positive regulation of neuron apoptotic processGO:004352510.068
regulation of cellular biosynthetic processGO:00313262450.068
immune system developmentGO:00025201910.067
regulation of sequestering of calcium ionGO:005128240.067
release of sequestered calcium ion into cytosolGO:005120930.066
regulation of rna biosynthetic processGO:20011412130.066
guanosine containing compound metabolic processGO:190106840.065
positive regulation of cellular component biogenesisGO:004408930.065
regulation of nitrogen compound metabolic processGO:00511712510.064
convergent extensionGO:00600261180.064
single organism metabolic processGO:00447102170.063
maintenance of locationGO:005123540.063
regulation of primary metabolic processGO:00800903110.063
establishment of endothelial barrierGO:006102830.063
cytosolic calcium ion transportGO:006040130.063
response to external stimulusGO:00096052640.061
neuron projection developmentGO:00311751800.061
digestive tract morphogenesisGO:00485462310.061
autophagyGO:000691440.061
heart loopingGO:0001947940.061
melanin metabolic processGO:000658220.061
signal transductionGO:00071654550.061
generation of neuronsGO:00486993850.059
modification dependent macromolecule catabolic processGO:004363230.058
activation of jun kinase activityGO:000725720.058
response to chemicalGO:00422213200.058
mitotic cell cycleGO:0000278640.058
negative regulation of biological processGO:00485193040.057
cell morphogenesisGO:00009022890.057
cell morphogenesis involved in neuron differentiationGO:00486671630.057
positive regulation of transportGO:005105020.057
sequestering of metal ionGO:005123830.057
positive regulation of programmed cell deathGO:0043068290.056
regulation of signal transductionGO:00099662250.056
dorsal convergenceGO:0060030140.056
spindle assemblyGO:005122520.056
positive regulation of biological processGO:00485182530.056
cell surface receptor signaling pathwayGO:00071663250.056
ventricular system developmentGO:0021591120.055
brain developmentGO:00074202930.055
digestive system developmentGO:00551232890.055
regulation of macromolecule biosynthetic processGO:00105562250.054
cellular biosynthetic processGO:00442492860.054
regulation of proteolysis involved in cellular protein catabolic processGO:190305010.053
developmental growth involved in morphogenesisGO:0060560860.052
regulation of biosynthetic processGO:00098892500.052
stem cell divisionGO:001714510.052
cellular component morphogenesisGO:00329893360.051
hematopoietic or lymphoid organ developmentGO:00485341910.051
cell projection morphogenesisGO:00488582440.051
cell migration involved in gastrulationGO:0042074790.051
biosynthetic processGO:00090582940.051
female meiotic divisionGO:000714320.051
programmed cell deathGO:00125011190.050
skeletal system developmentGO:00015011810.050
mitotic cell cycle processGO:1903047480.050
cellular component disassemblyGO:002241110.050
regulation of jun kinase activityGO:004350630.050
stem cell maintenanceGO:001982740.049
cellular component assemblyGO:00226071700.049
regulation of synapse organizationGO:005080730.049
gtp metabolic processGO:004603940.049
determination of dorsal identityGO:0048263130.049
protein metabolic processGO:00195381830.049
metal ion transportGO:0030001580.048
response to uvGO:000941130.048
meiotic cell cycle processGO:190304630.048
single organism organelle organizationGO:19025891990.047
cell morphogenesis involved in differentiationGO:00009041950.046
cell growthGO:0016049570.046
somatic stem cell maintenanceGO:003501910.046
nucleic acid metabolic processGO:00903042440.046
regulation of endocytosisGO:003010070.046
non canonical wnt signaling pathwayGO:0035567130.045
neuron projection morphogenesisGO:00488121610.045
sequestering of calcium ionGO:005120830.045
organic substance biosynthetic processGO:19015762890.045
cell cycleGO:0007049930.045
cellular response to chemical stimulusGO:00708871570.045
positive regulation of cytosolic calcium ion concentrationGO:000720440.045
stem cell proliferationGO:007208940.044
regulation of nucleobase containing compound metabolic processGO:00192192500.044
cell part morphogenesisGO:00329902460.044
developmental cell growthGO:0048588520.043
positive regulation of map kinase activityGO:004340630.043
cortical actin cytoskeleton organizationGO:003086610.043
ion transportGO:00068111140.043
locomotionGO:00400113130.043
rna metabolic processGO:00160702190.042
cell motilityGO:00488702440.042
regulation of rna metabolic processGO:00512522240.042
transcription dna templatedGO:00063511810.042
determination of heart left right asymmetryGO:00613711170.042
sensory organ developmentGO:00074233930.042
meiotic chromosome segregationGO:004513230.042
protein targeting to nucleusGO:004474430.042
regulation of cellular protein catabolic processGO:190336210.041
regulation of developmental processGO:00507932470.041
central nervous system developmentGO:00074173870.041
heart developmentGO:00075073130.040
cellular component movementGO:00069283350.040
positive regulation of purine nucleotide catabolic processGO:003312310.040
muscle structure developmentGO:00610611960.040
neuron projection extensionGO:1990138450.040
nuclear transportGO:005116940.039
nucleobase containing compound metabolic processGO:00061392740.038
regulation of mrna splicing via spliceosomeGO:004802430.038
head developmentGO:00603223030.038
positive regulation of nucleoside metabolic processGO:004597910.038
cellular protein metabolic processGO:00442671290.038
regulation of cell developmentGO:00602841000.038
nuclear importGO:005117030.037
heart morphogenesisGO:00030071560.037
gtp catabolic processGO:000618420.037
apoptotic process involved in developmentGO:190274220.037
rna biosynthetic processGO:00327741810.036
cellular response to nutrient levelsGO:003166920.036
adherens junction organizationGO:003433240.036
digestive tract developmentGO:00485652650.036
organelle fissionGO:0048285230.036
protein modification processGO:00362111000.036
positive regulation of gtpase activityGO:004354710.035
morphogenesis of an epitheliumGO:00020093330.035
phosphate containing compound metabolic processGO:00067961080.035
positive regulation of cellular processGO:00485222010.035
organelle fusionGO:004828430.035
axon developmentGO:00615641660.034
mitotic nuclear divisionGO:0007067180.034
spindle localizationGO:0051653120.034
membrane invaginationGO:001032410.034
ribosomal small subunit biogenesisGO:004227420.034
xenobiotic metabolic processGO:000680540.034
cell migrationGO:00164772370.034
phosphorus metabolic processGO:00067931090.034
cellular component biogenesisGO:00440851780.034
regulation of cell communicationGO:00106462320.034
positive regulation of cell deathGO:0010942290.034
enzyme linked receptor protein signaling pathwayGO:00071671060.034
regulation of synapse assemblyGO:005196330.034
protein import into nucleusGO:000660630.034
response to cadmium ionGO:0046686140.034
neuron differentiationGO:00301823530.033
cation transportGO:0006812810.033
organic cyclic compound biosynthetic processGO:19013622230.033
response to stressGO:00069502630.033
regulation of chromosome segregationGO:005198310.033
microtubule cytoskeleton organizationGO:0000226330.033
eye developmentGO:00016542770.033
regulation of protein metabolic processGO:0051246560.033
negative regulation of canonical wnt signaling pathwayGO:0090090210.033
regulation of cellular macromolecule biosynthetic processGO:20001122220.033
protein polymerizationGO:005125840.033
ectoderm developmentGO:000739890.033
cellular response to extracellular stimulusGO:003166820.033
cellular response to starvationGO:000926710.033
neuromuscular synaptic transmissionGO:000727420.032
transportGO:00068102200.032
positive regulation of neuron deathGO:190121610.032
response to organic substanceGO:00100331530.032
cortical cytoskeleton organizationGO:003086510.032
regulation of epithelial cell proliferationGO:005067830.032
single fertilizationGO:000733830.032
regulation of autophagyGO:001050630.032
nucleic acid templated transcriptionGO:00976591810.031
response to other organismGO:0051707970.031
epithalamus developmentGO:0021538100.031
fertilizationGO:000956630.031
regulation of nucleotide catabolic processGO:003081120.031
regulation of cell differentiationGO:00455951420.031
nucleocytoplasmic transportGO:000691340.031
embryonic heart tube morphogenesisGO:00031431080.031
cell projection organizationGO:00300302840.031
regulation of cell cycle processGO:0010564200.031
regulation of signalingGO:00230512350.030
rostrocaudal neural tube patterningGO:0021903290.030
wound healingGO:0042060900.030
establishment of mitotic spindle orientationGO:0000132100.030
developmental growthGO:00485891660.030
canonical wnt signaling pathwayGO:0060070480.030
actomyosin structure organizationGO:0031032530.030
organelle assemblyGO:00709251100.030
negative regulation of cellular processGO:00485232830.029
embryonic camera type eye morphogenesisGO:0048596190.029
regulation of gtp catabolic processGO:003312420.029
single organism membrane fusionGO:004480120.029
neurotransmitter transportGO:000683620.029
establishment of spindle localizationGO:0051293120.029
synaptic growth at neuromuscular junctionGO:005112420.029
aromatic compound biosynthetic processGO:00194382170.029
multicellular organism growthGO:003526440.029
intracellular signal transductionGO:0035556850.029
epithelial tube morphogenesisGO:00605621480.029
axon extensionGO:0048675450.029
establishment of protein localization to organelleGO:007259440.029
wnt signaling pathwayGO:0016055800.029
regulation of nucleoside metabolic processGO:000911820.029
endosomal transportGO:001619720.029
negative regulation of signalingGO:0023057960.029
activation of mapk activityGO:000018730.029
peptidyl serine modificationGO:001820920.029
macromolecule modificationGO:00434121110.029
regulation of nucleic acid templated transcriptionGO:19035062130.029
regulation of axon extensionGO:0030516240.028
embryonic limb morphogenesisGO:003032620.028
positive regulation of striated muscle tissue developmentGO:004584410.028
negative regulation of kinase activityGO:003367340.028
ear developmentGO:00435831270.028
regulation of protein complex assemblyGO:004325430.028
regulation of alternative mrna splicing via spliceosomeGO:000038110.028
forebrain developmentGO:0030900960.028
axonogenesisGO:00074091520.028
regulation of cell divisionGO:0051302120.028
regulation of cell growthGO:0001558290.027
regulation of purine nucleotide catabolic processGO:003312120.027
positive regulation of metabolic processGO:00098931080.027
negative regulation of response to stimulusGO:00485851040.027
hepaticobiliary system developmentGO:0061008980.027
protein complex localizationGO:003150310.027
embryonic organ developmentGO:00485683810.027
protein importGO:001703830.027
positive regulation of gtp catabolic processGO:003312610.027
protein localization to nucleusGO:003450430.027
regulation of cytokine productionGO:000181730.026
localization of cellGO:00516742440.026
cellular nitrogen compound biosynthetic processGO:00442712180.026
protein localization to plasma membraneGO:007265910.026
negative regulation of signal transductionGO:0009968940.026
positive regulation of apoptotic processGO:0043065290.026
blood vessel developmentGO:00015682460.026
cytokinetic processGO:003250620.026
neural plate pattern specificationGO:0060896120.026
response to copper ionGO:0046688130.026
peptidyl serine phosphorylationGO:001810510.026
habenula developmentGO:002198690.026
carbohydrate homeostasisGO:003350010.026
positive regulation of synapse assemblyGO:005196510.026
embryonic organ morphogenesisGO:00485622740.026
phagocytosis engulfmentGO:000691110.025
regulation of neurogenesisGO:0050767870.025
golgi vesicle transportGO:004819330.025
growthGO:00400071740.025
otolith developmentGO:0048840320.025
regulation of reproductive processGO:200024140.025
homeostatic processGO:00425921420.025
inner ear developmentGO:00488391260.025
striated muscle cell differentiationGO:00511461290.025
regulation of cellular amino acid metabolic processGO:000652100.025
synaptic transmission cholinergicGO:000727140.025
liver developmentGO:0001889960.024
neurotransmitter secretionGO:000726920.024
positive regulation of cytoskeleton organizationGO:005149530.024
regulation of meiotic cell cycleGO:005144510.024
regulation of intracellular protein transportGO:003315730.024
cellular amino acid metabolic processGO:000652070.024
apoptotic processGO:00069151160.024
acylglycerol homeostasisGO:005509020.024
nucleobase containing compound biosynthetic processGO:00346542050.024
regulation of programmed cell deathGO:00430671010.023
response to external biotic stimulusGO:0043207970.023
regulation of cellular amine metabolic processGO:003323800.023
actin filament polymerizationGO:003004120.023
regulation of transcription dna templatedGO:00063552130.023
sensory organ morphogenesisGO:00905962000.023
specification of axis polarityGO:006500140.023
cell deathGO:00082191210.023
actin cytoskeleton organizationGO:0030036630.023
neuroblast proliferationGO:000740520.023
regulation of transmembrane receptor protein serine threonine kinase signaling pathwayGO:0090092500.023
regulation of fibroblast growth factor receptor signaling pathwayGO:0040036200.023
cytoskeleton dependent cytokinesisGO:006164030.023
regulation of growth rateGO:004000910.023
positive regulation of protein complex assemblyGO:003133420.023
cellular amine metabolic processGO:004410620.023
female sex differentiationGO:004666040.023
response to corticosteroidGO:003196010.023
ectodermal placode developmentGO:0071696370.023
i kappab kinase nf kappab signalingGO:000724940.023
establishment of cell polarityGO:0030010180.023
cellular protein modification processGO:00064641000.022
lateral line developmentGO:0048882660.022
estrogen metabolic processGO:000821020.022
regulation of protein modification by small protein conjugation or removalGO:190332030.022
positive regulation of muscle tissue developmentGO:190186310.022
regulation of dendrite developmentGO:005077330.022
cellular ketone metabolic processGO:0042180110.022
establishment of localization in cellGO:0051649770.022
regulation of neuron differentiationGO:0045664560.022
negative regulation of catabolic processGO:000989530.022
regulation of cellular component organizationGO:0051128860.022
regulation of multicellular organismal processGO:00512392770.022
extrinsic apoptotic signaling pathwayGO:009719130.022
ectodermal placode morphogenesisGO:0071697320.022
negative regulation of protein phosphorylationGO:000193340.022
tissue remodelingGO:004877140.022
nephron epithelium morphogenesisGO:007208810.022
wnt signaling pathway calcium modulating pathwayGO:000722350.022
embryonic pattern specificationGO:0009880440.022
positive regulation of nucleotide catabolic processGO:003081310.022
cellular response to organic substanceGO:00713101050.022
amine metabolic processGO:000930820.022
endoderm developmentGO:0007492490.022
triglyceride homeostasisGO:007032820.021
alternative mrna splicing via spliceosomeGO:000038010.021
response to alkaloidGO:004327920.021
angiogenesisGO:00015251580.021
regulation of multicellular organismal developmentGO:20000262230.021
regulation of peptidase activityGO:0052547230.021
single organism cellular localizationGO:1902580460.021
female gonad developmentGO:000858540.021
regulation of cell sizeGO:0008361290.021
muscle organ developmentGO:00075171010.021
negative regulation of cell fate commitmentGO:0010454130.021
regulation of cell matrix adhesionGO:000195210.021
compound eye developmentGO:004874920.021
oocyte differentiationGO:0009994140.021
positive regulation of epithelial cell differentiationGO:003085820.021
regulation of cell cycleGO:0051726520.021
tissue regenerationGO:0042246740.021
positive regulation of nucleobase containing compound metabolic processGO:0045935690.021
cellular localizationGO:0051641970.021
response to woundingGO:00096111160.021
negative regulation of map kinase activityGO:004340720.021
sensory system developmentGO:0048880760.021
mitochondrion organizationGO:000700540.021
developmental programmed cell deathGO:001062340.021
regulation of cell substrate adhesionGO:001081010.021
positive regulation of macromolecule metabolic processGO:0010604930.021
convergent extension involved in axis elongationGO:0060028260.021
pancreas developmentGO:0031016840.021
regulation of synaptic growth at neuromuscular junctionGO:000858210.021
positive regulation of muscle cell differentiationGO:005114910.021
positive regulation of signalingGO:0023056560.021
nephron morphogenesisGO:007202820.020
regulation of behaviorGO:0050795240.020
regulation of protein import into nucleusGO:004230620.020
positive regulation of cellular amino acid metabolic processGO:004576400.020
striated muscle cell developmentGO:00550021080.020
g1 s transition of mitotic cell cycleGO:000008210.020
divalent metal ion transportGO:0070838200.020
vasculature developmentGO:00019442780.020
spinal cord developmentGO:0021510460.020
myeloid cell differentiationGO:0030099860.020
gland developmentGO:00487321430.020
connective tissue developmentGO:0061448990.020
midbrain hindbrain boundary developmentGO:0030917230.020
liver morphogenesisGO:007257680.020
macroautophagyGO:001623610.020
kupffer s vesicle developmentGO:0070121500.020
mitotic dna integrity checkpointGO:004477440.020
organonitrogen compound metabolic processGO:1901564740.020
regulation of endocrine processGO:004406020.020
actin polymerization or depolymerizationGO:000815420.020
regulation of establishment of protein localizationGO:007020140.020
cell substrate adhesionGO:003158940.020
purine ribonucleoside monophosphate catabolic processGO:000916940.020
negative regulation of cell communicationGO:0010648960.020
spindle assembly involved in mitosisGO:009030710.020
organelle localizationGO:0051640490.019
notch signaling pathwayGO:0007219350.019
membrane fusionGO:006102520.019
taxisGO:00423301090.019
otic vesicle developmentGO:0071599420.019
regulation of nervous system developmentGO:0051960900.019
fourth ventricle developmentGO:002159280.019
regulation of response to stimulusGO:00485832690.019
diencephalon developmentGO:0021536580.019
notochord developmentGO:0030903540.019
response to light stimulusGO:0009416460.019
single organism nuclear importGO:190259330.019
regulation of dna replicationGO:000627530.019
regulation of gtpase activityGO:004308720.019
epithelium regenerationGO:1990399140.019
cellular response to fibroblast growth factor stimulusGO:0044344220.019
spermatid differentiationGO:004851520.019
deathGO:00162651210.019
positive regulation of cell divisionGO:005178120.019
neuromast developmentGO:0048884460.019
negative regulation of synapse assemblyGO:005196420.019
gastrulation with mouth forming secondGO:0001702440.018
positive regulation of nucleic acid templated transcriptionGO:1903508570.018
regulation of protein polymerizationGO:003227120.018
positive regulation of epithelial cell proliferationGO:005067910.018
positive regulation of nitrogen compound metabolic processGO:0051173690.018
positive regulation of striated muscle cell differentiationGO:005115510.018
regulation of multicellular organism growthGO:004001440.018
lateral line system developmentGO:0048925760.018
cellular carbohydrate metabolic processGO:004426240.018
regulation of nucleocytoplasmic transportGO:004682220.018
regulation of protein transportGO:005122330.018
skeletal muscle organ developmentGO:0060538780.018
intracellular transportGO:0046907320.018
positive regulation of cellular metabolic processGO:0031325940.018
otic vesicle morphogenesisGO:0071600340.018
cellular component assembly involved in morphogenesisGO:00109271070.018
regulation of cellular protein metabolic processGO:0032268520.018
regulation of i kappab kinase nf kappab signalingGO:004312240.018
response to glucocorticoidGO:005138410.018
cell cycle processGO:0022402530.017
protein phosphorylationGO:0006468470.017
regulation of apoptotic processGO:0042981980.017
embryonic eye morphogenesisGO:0048048300.017
multi organism processGO:00517041340.017
regulation of cell deathGO:00109411030.017
cell cycle g2 m phase transitionGO:004483940.017
oxoacid metabolic processGO:0043436310.017
establishment of spindle orientationGO:0051294100.017
common bile duct developmentGO:0061009130.017
macromolecular complex disassemblyGO:003298410.017
eye field cell fate commitment involved in camera type eye formationGO:006089830.017
regulation of wnt signaling pathway involved in dorsal ventral axis specificationGO:200005350.017
determination of ventral identityGO:0048264210.017

map2k4b disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.036
nervous system diseaseDOID:86300.018