Danio rerio

13 known processes

ptrfb

polymerase I and transcript release factor b

(Aliases: MGC162917,ptrf,wu:fd20g07,zgc:162917,fd20g07)

ptrfb biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
signal transductionGO:00071654550.406
angiogenesisGO:00015251580.325
vasculature developmentGO:00019442780.301
regulation of epithelial cell proliferationGO:005067830.272
positive regulation of cellular processGO:00485222010.263
organic cyclic compound biosynthetic processGO:19013622230.236
hematopoietic or lymphoid organ developmentGO:00485341910.234
regulation of cell communicationGO:00106462320.225
regulation of signalingGO:00230512350.222
stem cell proliferationGO:007208940.221
immune system processGO:00023762410.206
response to chemicalGO:00422213200.205
regulation of inflammatory responseGO:005072720.199
cell surface receptor signaling pathwayGO:00071663250.191
larval developmentGO:000216420.182
response to external stimulusGO:00096052640.175
sprouting angiogenesisGO:0002040530.172
embryonic organ developmentGO:00485683810.171
transcription dna templatedGO:00063511810.170
positive regulation of biological processGO:00485182530.170
biological adhesionGO:0022610400.169
determination of bilateral symmetryGO:00098552040.167
chemotaxisGO:00069351040.165
morphogenesis of an epitheliumGO:00020093330.161
negative regulation of biological processGO:00485193040.161
embryonic organ morphogenesisGO:00485622740.161
gland developmentGO:00487321430.160
regulation of gene expressionGO:00104682650.160
stem cell differentiationGO:00488631170.151
regulation of transcription dna templatedGO:00063552130.149
blood vessel morphogenesisGO:00485142160.148
establishment of protein localization to organelleGO:007259440.148
regulation of signal transductionGO:00099662250.147
positive regulation of cellular component biogenesisGO:004408930.144
positive regulation of epithelial cell proliferationGO:005067910.141
cell morphogenesis involved in neuron differentiationGO:00486671630.139
regulation of response to stimulusGO:00485832690.138
organic cyclic compound metabolic processGO:19013603010.136
cellular aromatic compound metabolic processGO:00067252950.131
regulation of cell motilityGO:2000145460.130
tube morphogenesisGO:00352393490.127
stem cell maintenanceGO:001982740.126
blood vessel developmentGO:00015682460.125
biosynthetic processGO:00090582940.125
cell migrationGO:00164772370.124
agingGO:000756820.124
cellular component movementGO:00069283350.123
cell migration involved in gastrulationGO:0042074790.122
somite developmentGO:0061053960.113
organelle organizationGO:00069962270.113
guanosine containing compound catabolic processGO:190106920.113
localization of cellGO:00516742440.110
protein localization to nucleusGO:003450430.109
ameboidal type cell migrationGO:00016671430.109
wound healingGO:0042060900.108
system processGO:00030081850.107
specification of symmetryGO:00097992040.105
multicellular organismal homeostasisGO:0048871290.103
transcription from rna polymerase ii promoterGO:0006366800.103
regulation of protein transportGO:005122330.102
regulation of nucleobase containing compound metabolic processGO:00192192500.101
positive regulation of transportGO:005105020.098
generation of neuronsGO:00486993850.096
guanosine containing compound metabolic processGO:190106840.096
regulation of catalytic activityGO:0050790550.095
nucleocytoplasmic transportGO:000691340.094
protein targeting to nucleusGO:004474430.093
regulation of skeletal muscle tissue developmentGO:004864140.093
regulation of transcription from rna polymerase ii promoter in response to stressGO:004361800.089
positive regulation of programmed cell deathGO:0043068290.089
wnt signaling pathwayGO:0016055800.088
mesenchymal cell differentiationGO:0048762870.088
positive regulation of response to stimulusGO:0048584800.087
regulation of cellular metabolic processGO:00313233200.086
regulation of biological qualityGO:00650082630.085
organic substance biosynthetic processGO:19015762890.085
protein import into nucleusGO:000660630.084
regenerationGO:0031099910.082
regulation of protein targetingGO:190353320.082
small gtpase mediated signal transductionGO:000726480.081
regulation of cellular amine metabolic processGO:003323800.081
response to hypoxiaGO:0001666250.081
regulation of protein import into nucleusGO:004230620.080
aromatic compound biosynthetic processGO:00194382170.080
regulation of establishment of protein localizationGO:007020140.079
camera type eye developmentGO:00430102220.078
regulation of chemotaxisGO:0050920180.078
neuron projection guidanceGO:0097485860.078
cell adhesionGO:0007155400.078
cellular component morphogenesisGO:00329893360.077
regulation of stem cell proliferationGO:007209120.077
nuclear transportGO:005116940.077
cellular nitrogen compound metabolic processGO:00346412900.076
heterocycle biosynthetic processGO:00181302150.076
regulation of macromolecule metabolic processGO:00602553170.074
regulation of protein complex assemblyGO:004325430.073
response to stressGO:00069502630.072
muscle structure developmentGO:00610611960.071
gtp catabolic processGO:000618420.070
extrinsic apoptotic signaling pathwayGO:009719130.070
nucleobase containing compound metabolic processGO:00061392740.070
regulation of metabolic processGO:00192223590.070
regulation of protein localization to nucleusGO:190018020.069
cell substrate adhesionGO:003158940.069
regulation of nucleotide catabolic processGO:003081120.068
embryo development ending in birth or egg hatchingGO:00097922710.068
regulation of nucleocytoplasmic transportGO:004682220.068
negative regulation of protein kinase activityGO:000646940.067
cell morphogenesisGO:00009022890.067
regulation of cellular component movementGO:0051270550.067
positive regulation of erk1 and erk2 cascadeGO:007037420.066
gene expressionGO:00104672520.065
gtp metabolic processGO:004603940.064
muscle organ developmentGO:00075171010.064
regulation of synapse organizationGO:005080730.064
regulation of dna templated transcription in response to stressGO:004362000.064
positive regulation of cell communicationGO:0010647560.063
regulation of extrinsic apoptotic signaling pathwayGO:200123630.063
central nervous system developmentGO:00074173870.062
negative regulation of epithelial cell migrationGO:001063310.061
single organism nuclear importGO:190259330.061
regulation of cell adhesionGO:0030155150.061
cellular macromolecule metabolic processGO:00442603910.061
embryonic heart tube morphogenesisGO:00031431080.060
regulation of cytokine productionGO:000181730.060
negative regulation of protein phosphorylationGO:000193340.060
embryonic skeletal system developmentGO:0048706970.060
negative regulation of gliogenesisGO:001401410.060
regulation of multicellular organismal developmentGO:20000262230.059
negative regulation of cellular processGO:00485232830.059
positive regulation of metabolic processGO:00098931080.059
heart contractionGO:0060047710.059
membrane fusionGO:006102520.059
positive regulation of nitrogen compound metabolic processGO:0051173690.059
cellular protein metabolic processGO:00442671290.058
skeletal muscle organ developmentGO:0060538780.058
neuron projection morphogenesisGO:00488121610.057
otic vesicle developmentGO:0071599420.057
cell motilityGO:00488702440.057
response to other organismGO:0051707970.057
protein metabolic processGO:00195381830.057
protein localizationGO:0008104400.056
single organism metabolic processGO:00447102170.056
negative regulation of secretionGO:005104820.056
sensory organ morphogenesisGO:00905962000.056
locomotionGO:00400113130.056
lymph vessel developmentGO:0001945270.056
hemopoiesisGO:00300971830.055
single organism organelle organizationGO:19025891990.055
positive regulation of canonical wnt signaling pathwayGO:009026340.055
response to external biotic stimulusGO:0043207970.055
positive regulation of cytokine productionGO:000181920.054
cell part morphogenesisGO:00329902460.054
positive regulation of gtp catabolic processGO:003312610.054
positive regulation of response to external stimulusGO:003210390.053
nucleic acid metabolic processGO:00903042440.053
cellular response to molecule of bacterial originGO:007121930.052
positive regulation of rna metabolic processGO:0051254590.051
phosphorylationGO:0016310690.050
cellular protein modification processGO:00064641000.049
negative regulation of response to stimulusGO:00485851040.049
regulation of protein metabolic processGO:0051246560.048
antimicrobial humoral responseGO:001973020.048
cellular response to vascular endothelial growth factor stimulusGO:003592430.048
positive regulation of myeloid cell differentiationGO:004563920.047
regulation of primary metabolic processGO:00800903110.047
cell cycleGO:0007049930.047
enzyme linked receptor protein signaling pathwayGO:00071671060.047
nuclear importGO:005117030.047
positive regulation of signal transductionGO:0009967560.047
positive regulation of gene expressionGO:0010628710.046
cellular component biogenesisGO:00440851780.046
regulation of cytoplasmic transportGO:190364940.046
determination of left right symmetryGO:00073681790.046
single organism localizationGO:19025782250.046
regulation of biosynthetic processGO:00098892500.045
hepaticobiliary system developmentGO:0061008980.045
neuroblast proliferationGO:000740520.045
regulation of locomotionGO:0040012550.045
protein polymerizationGO:005125840.045
regulation of transcription from rna polymerase ii promoterGO:00063571140.044
cell proliferationGO:0008283800.044
organonitrogen compound metabolic processGO:1901564740.044
cellular nitrogen compound biosynthetic processGO:00442712180.044
regulation of nitrogen compound metabolic processGO:00511712510.044
regulation of synapse assemblyGO:005196330.043
immune system developmentGO:00025201910.043
regulation of peptidase activityGO:0052547230.043
sensory organ developmentGO:00074233930.043
regulation of erk1 and erk2 cascadeGO:007037240.043
regulation of nucleoside metabolic processGO:000911820.043
secondary metabolic processGO:001974830.043
tissue regenerationGO:0042246740.043
blood vessel endothelial cell migrationGO:0043534180.042
macrophage differentiationGO:003022570.042
digestive tract morphogenesisGO:00485462310.042
neuron neuron synaptic transmissionGO:000727010.042
macromolecule biosynthetic processGO:00090592270.042
response to metal ionGO:0010038340.042
stem cell developmentGO:0048864820.042
single organism membrane fusionGO:004480120.042
negative regulation of defense responseGO:003134820.041
regulation of purine nucleotide catabolic processGO:003312120.041
positive regulation of cellular protein metabolic processGO:0032270220.041
response to woundingGO:00096111160.040
regulation of dna templated transcription elongationGO:003278430.040
negative regulation of gene expressionGO:0010629650.040
regulation of intracellular protein transportGO:003315730.040
macromolecule modificationGO:00434121110.040
regulation of rna biosynthetic processGO:20011412130.040
regulation of gtp catabolic processGO:003312420.039
negative regulation of signalingGO:0023057960.039
protein secretionGO:000930610.039
response to decreased oxygen levelsGO:0036293250.039
cognitionGO:005089010.039
axonogenesisGO:00074091520.038
negative regulation of chemotaxisGO:005092240.038
positive regulation of epithelial cell migrationGO:001063420.038
positive regulation of camp metabolic processGO:003081620.038
liver developmentGO:0001889960.038
regulation of endothelial cell proliferationGO:000193610.038
cellular biosynthetic processGO:00442492860.038
organelle fusionGO:004828430.038
cellular component assemblyGO:00226071700.038
regulation of gtpase activityGO:004308720.037
tissue migrationGO:0090130370.037
single organism cell adhesionGO:0098602290.037
regulation of cell migrationGO:0030334400.037
regulation of bindingGO:005109830.037
embryonic heart tube developmentGO:00350501330.037
positive regulation of apoptotic signaling pathwayGO:200123510.037
monoamine transportGO:001584410.036
epithelial cell migrationGO:0010631250.036
peptidyl serine modificationGO:001820920.036
mesenchymal cell developmentGO:0014031780.035
regulation of cell substrate adhesionGO:001081010.035
regulation of multicellular organismal processGO:00512392770.035
positive regulation of cellular amine metabolic processGO:003324000.035
regulation of protein polymerizationGO:003227120.035
negative regulation of neural precursor cell proliferationGO:200017810.035
regulation of neural precursor cell proliferationGO:200017730.034
melanin metabolic processGO:000658220.034
regulation of multicellular organism growthGO:004001440.034
phagocytosisGO:000690930.034
negative regulation of multicellular organismal processGO:0051241690.034
phosphorus metabolic processGO:00067931090.034
positive regulation of locomotionGO:0040017140.034
erk1 and erk2 cascadeGO:007037140.033
neural crest cell differentiationGO:0014033720.033
response to biotic stimulusGO:0009607970.033
negative regulation of kinase activityGO:003367340.033
somitogenesisGO:0001756870.033
regulation of cell proliferationGO:0042127370.033
regulation of vasculature developmentGO:1901342330.033
circulatory system processGO:0003013870.033
positive regulation of hydrolase activityGO:0051345130.033
rna biosynthetic processGO:00327741810.033
pericardium developmentGO:006003910.033
positive regulation of macromolecule metabolic processGO:0010604930.033
response to inorganic substanceGO:0010035380.033
lateral line developmentGO:0048882660.033
regulation of cellular amino acid metabolic processGO:000652100.032
regulation of wound healingGO:006104120.032
positive regulation of biosynthetic processGO:0009891680.032
positive regulation of inflammatory responseGO:005072910.032
positive regulation of cellular metabolic processGO:0031325940.032
regulation of cytoskeleton organizationGO:0051493110.031
cell matrix adhesionGO:000716040.031
signal transduction by phosphorylationGO:0023014180.031
collagen fibril organizationGO:003019910.031
intracellular signal transductionGO:0035556850.031
regulation of rna metabolic processGO:00512522240.031
regulation of protein phosphorylationGO:0001932180.031
ras protein signal transductionGO:000726570.031
regulation of stem cell differentiationGO:200073640.031
regulation of synaptic growth at neuromuscular junctionGO:000858210.030
regulation of cellular macromolecule biosynthetic processGO:20001122220.030
somatic stem cell maintenanceGO:003501910.030
regulation of erythrocyte differentiationGO:004564620.030
cellular response to growth factor stimulusGO:0071363390.030
dna templated transcription elongationGO:000635430.029
digestive tract developmentGO:00485652650.029
gland morphogenesisGO:0022612130.029
regulation of anatomical structure morphogenesisGO:00226031300.029
regulation of response to external stimulusGO:0032101310.029
protein acetylationGO:000647320.029
regulation of synaptic plasticityGO:004816710.029
regulation of transmembrane receptor protein serine threonine kinase signaling pathwayGO:0090092500.029
positive regulation of signalingGO:0023056560.028
regulation of transcription elongation from rna polymerase ii promoterGO:003424330.028
regulation of i kappab kinase nf kappab signalingGO:004312240.028
negative regulation of developmental processGO:0051093650.028
nucleobase containing compound biosynthetic processGO:00346542050.028
cytokinesisGO:000091030.028
positive regulation of cellular component movementGO:0051272110.028
production of molecular mediator of immune responseGO:000244020.028
positive regulation of endothelial cell proliferationGO:000193810.028
negative regulation of synapse assemblyGO:005196420.028
axis elongationGO:0003401310.027
cell projection organizationGO:00300302840.027
cytoskeleton organizationGO:0007010960.027
regulation of nucleic acid templated transcriptionGO:19035062130.027
embryonic hemopoiesisGO:0035162530.027
neuron developmentGO:00486662620.027
regulation of organelle organizationGO:0033043290.027
regulation of cell activationGO:005086510.027
myeloid cell differentiationGO:0030099860.027
response to lipidGO:0033993600.027
regulation of molecular functionGO:0065009700.027
positive regulation of cellular amino acid metabolic processGO:004576400.026
regulation of cell morphogenesis involved in differentiationGO:0010769380.026
taxisGO:00423301090.026
actin polymerization or depolymerizationGO:000815420.026
peptidyl serine phosphorylationGO:001810510.026
regulation of axon guidanceGO:190266780.026
meiotic cell cycle processGO:190304630.026
regulation of cell shapeGO:000836010.026
regulation of protein catabolic processGO:004217610.026
astrocyte differentiationGO:004870810.026
single organismal cell cell adhesionGO:0016337290.026
cell migration involved in vasculogenesisGO:003544110.026
positive regulation of histone modificationGO:003105810.026
adherens junction organizationGO:003433240.025
transmembrane receptor protein serine threonine kinase signaling pathwayGO:0007178680.025
negative regulation of macromolecule metabolic processGO:0010605760.025
positive regulation of cellular catabolic processGO:003133130.025
establishment or maintenance of cell polarityGO:0007163290.025
cellular amino acid metabolic processGO:000652070.025
regulation of developmental processGO:00507932470.025
amine metabolic processGO:000930820.025
sensory system developmentGO:0048880760.025
regulation of hydrolase activityGO:0051336280.025
regulation of neurogenesisGO:0050767870.025
rna metabolic processGO:00160702190.025
protein importGO:001703830.025
mesodermal cell migrationGO:0008078120.025
phosphate containing compound metabolic processGO:00067961080.025
regulation of cellular biosynthetic processGO:00313262450.025
regulation of wnt signaling pathwayGO:0030111530.025
striated muscle cell developmentGO:00550021080.024
cellular ketone metabolic processGO:0042180110.024
negative regulation of map kinase activityGO:004340720.024
negative regulation of protein transportGO:005122430.024
protein modification processGO:00362111000.024
branchiomotor neuron axon guidanceGO:002178510.024
positive regulation of protein metabolic processGO:0051247230.024
regulation of localizationGO:00328791040.024
regulation of cell deathGO:00109411030.024
regulation of cellular protein metabolic processGO:0032268520.024
nucleic acid templated transcriptionGO:00976591810.024
neurotransmitter transportGO:000683620.023
negative regulation of small gtpase mediated signal transductionGO:005105810.023
response to oxygen levelsGO:0070482250.023
neuron projection developmentGO:00311751800.023
dorsal ventral pattern formationGO:00099531250.023
positive regulation of gtpase activityGO:004354710.023
positive regulation of endothelial cell migrationGO:001059520.023
single organism transportGO:00447652060.023
fatty acid transportGO:001590810.023
fin regenerationGO:0031101510.023
notochord developmentGO:0030903540.023
positive regulation of macromolecule biosynthetic processGO:0010557590.023
branching morphogenesis of a nerveGO:004875540.023
positive regulation of protein complex assemblyGO:003133420.023
long chain fatty acid transportGO:001590910.022
negative regulation of axon extension involved in axon guidanceGO:004884310.022
eye developmentGO:00016542770.022
programmed cell deathGO:00125011190.022
positive regulation of secretion by cellGO:190353210.022
positive regulation of secretionGO:005104710.022
heart processGO:0003015710.022
negative regulation of cell communicationGO:0010648960.022
regulation of intracellular signal transductionGO:1902531570.022
segmentationGO:0035282970.022
i kappab kinase nf kappab signalingGO:000724940.022
neural crest cell developmentGO:0014032620.022
positive regulation of apoptotic processGO:0043065290.022
specification of axis polarityGO:006500140.022
positive regulation of nucleotide catabolic processGO:003081310.022
protein complex assemblyGO:0006461300.022
positive regulation of cell adhesionGO:004578510.021
ovulation cycle processGO:002260220.021
regulation of mesenchymal cell proliferationGO:001046410.021
negative regulation of cytokine productionGO:000181810.021
regulation of cellular ketone metabolic processGO:001056570.021
regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:200123910.021
cell cycle g1 s phase transitionGO:004484310.021
macromolecular complex subunit organizationGO:0043933740.021
mesoderm developmentGO:0007498880.021
oxoacid metabolic processGO:0043436310.021
small molecule metabolic processGO:0044281770.021
response to corticosteroidGO:003196010.021
myeloid leukocyte differentiationGO:0002573150.020
multicellular organism growthGO:003526440.020
embryonic skeletal joint morphogenesisGO:006027230.020
establishment of localization in cellGO:0051649770.020
negative regulation of intracellular transportGO:003238730.020
glial cell differentiationGO:0010001420.020
epithelium migrationGO:0090132250.020
facial nerve morphogenesisGO:002161010.020
response to hostGO:007513620.020
establishment of localizationGO:00512342440.020
bmp signaling pathwayGO:0030509520.020
protein complex subunit organizationGO:0071822460.020
heart morphogenesisGO:00030071560.020
cell growthGO:0016049570.020
positive regulation of leukocyte mediated immunityGO:000270510.020
meiotic nuclear divisionGO:000712640.020
positive regulation of catalytic activityGO:0043085250.020
otic vesicle morphogenesisGO:0071600340.020
gliogenesisGO:0042063450.020
regulation of cell migration involved in sprouting angiogenesisGO:009004930.020
cell projection morphogenesisGO:00488582440.020
peripheral nervous system developmentGO:0007422550.020
epithelial cell differentiationGO:00308551160.020
chondrocyte developmentGO:000206340.020
axon guidanceGO:0007411860.020
single organism cellular localizationGO:1902580460.019
peripheral nervous system neuron differentiationGO:0048934280.019
b cell activationGO:004211320.019
growthGO:00400071740.019
negative regulation of metabolic processGO:0009892860.019
homeostatic processGO:00425921420.019
myeloid leukocyte migrationGO:0097529120.019
regulation of phosphorus metabolic processGO:0051174430.019
apoptotic processGO:00069151160.019
positive regulation of extrinsic apoptotic signaling pathwayGO:200123810.019
glial cell proliferationGO:001400940.019
positive regulation of neuron projection developmentGO:001097690.019
positive regulation of purine nucleotide catabolic processGO:003312310.019
positive regulation of catabolic processGO:000989640.019
kupffer s vesicle developmentGO:0070121500.018
membrane invaginationGO:001032410.018
organic acid metabolic processGO:0006082310.018
aorta developmentGO:003590440.018
cellular response to retinoic acidGO:007130010.018
inner ear developmentGO:00488391260.018
determination of heart left right asymmetryGO:00613711170.018
germ line stem cell maintenanceGO:003071820.018
positive regulation of immune effector processGO:000269930.018
determination of dorsal ventral asymmetryGO:0048262340.018
cellular amine metabolic processGO:004410620.018
actin filament based processGO:0030029640.018
cell deathGO:00082191210.018
cellular response to external stimulusGO:007149620.018
positive regulation of cell motilityGO:2000147110.018
protein complex biogenesisGO:0070271300.018
ubiquitin dependent protein catabolic processGO:000651130.018
axon developmentGO:00615641660.018
neuron differentiationGO:00301823530.018
hormone secretionGO:004687920.018
mesenchyme developmentGO:00604851270.018
post embryonic organ developmentGO:004856940.018
regulation of cell projection assemblyGO:006049140.018
regulation of apoptotic processGO:0042981980.018
regulation of camp biosynthetic processGO:003081790.018
response to abiotic stimulusGO:00096281220.018
anterior posterior pattern specificationGO:00099521520.017
axonal defasciculationGO:000741420.017
regulation of nervous system developmentGO:0051960900.017
positive regulation of peptidyl tyrosine phosphorylationGO:005073110.017
negative regulation of nitrogen compound metabolic processGO:0051172590.017
ribonucleotide biosynthetic processGO:0009260200.017
myeloid cell homeostasisGO:0002262560.017
canonical wnt signaling pathwayGO:0060070480.017
positive regulation of rna biosynthetic processGO:1902680570.017
positive regulation of cell cycleGO:004578730.017
calcium mediated signalingGO:001972220.017
actin filament organizationGO:0007015150.017
homeostasis of number of cellsGO:0048872620.017
vasculogenesisGO:0001570410.017
retinoic acid receptor signaling pathwayGO:0048384160.017
regulation of cysteine type endopeptidase activityGO:2000116210.016
regulation of cellular component organizationGO:0051128860.016
definitive hemopoiesisGO:0060216180.016
regulation of behaviorGO:0050795240.016
macromolecular complex assemblyGO:0065003350.016
erythrocyte homeostasisGO:0034101550.016
cellular response to oxygen levelsGO:007145310.016
inflammatory responseGO:000695480.016
endothelial cell migrationGO:0043542190.016
inner ear morphogenesisGO:0042472630.016
regulation of heart rateGO:000202750.016
regulation of transporter activityGO:003240920.016
regulation of peptidyl tyrosine phosphorylationGO:005073010.016

ptrfb disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
cardiovascular system diseaseDOID:128700.173
muscle tissue diseaseDOID:6600.173
musculoskeletal system diseaseDOID:1700.173
intrinsic cardiomyopathyDOID:006003600.173
disease of anatomical entityDOID:700.173
cardiomyopathyDOID:005070000.173
heart diseaseDOID:11400.173
muscular diseaseDOID:008000000.173
myopathyDOID:42300.173
immune system diseaseDOID:291400.096