Danio rerio

0 known processes

ptgis

prostaglandin I2 (prostacyclin) synthase

(Aliases: PGIS,ptgisl)

ptgis biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
regulation of cytokine productionGO:000181730.087
response to external stimulusGO:00096052640.072
larval developmentGO:000216420.067
regulation of protein localization to nucleusGO:190018020.064
response to chemicalGO:00422213200.064
i kappab kinase nf kappab signalingGO:000724940.061
protein import into nucleusGO:000660630.059
regulation of i kappab kinase nf kappab signalingGO:004312240.057
protein localization to nucleusGO:003450430.057
cellular response to lipopolysaccharideGO:007122230.055
positive regulation of cytokine productionGO:000181920.051
protein complex localizationGO:003150310.051
nucleobase containing compound biosynthetic processGO:00346542050.051
protein importGO:001703830.050
positive regulation of transportGO:005105020.050
regulation of signal transductionGO:00099662250.048
cellular component movementGO:00069283350.048
regulation of signalingGO:00230512350.048
regulation of reactive oxygen species metabolic processGO:200037720.047
regulation of biological qualityGO:00650082630.047
regulation of cell communicationGO:00106462320.046
nitrogen compound metabolic processGO:00068073190.045
locomotionGO:00400113130.044
regulation of protein import into nucleusGO:004230620.044
regulation of protein transportGO:005122330.044
positive regulation of cellular component biogenesisGO:004408930.043
lipid storageGO:001991510.043
cellular biosynthetic processGO:00442492860.043
regulation of intracellular protein transportGO:003315730.043
small molecule metabolic processGO:0044281770.042
localization of cellGO:00516742440.042
cellular response to chemical stimulusGO:00708871570.042
nucleocytoplasmic transportGO:000691340.042
negative regulation of sequence specific dna binding transcription factor activityGO:004343320.040
regulation of multicellular organismal processGO:00512392770.039
sensory organ developmentGO:00074233930.039
reactive oxygen species metabolic processGO:007259360.039
phagocytosisGO:000690930.038
meiotic nuclear divisionGO:000712640.037
positive regulation of cell cycleGO:004578730.037
regulation of response to stimulusGO:00485832690.037
regulation of bindingGO:005109830.036
positive regulation of response to stimulusGO:0048584800.036
cellular nitrogen compound biosynthetic processGO:00442712180.035
meiotic cell cycle processGO:190304630.034
regulation of cell differentiationGO:00455951420.033
regulation of biosynthetic processGO:00098892500.033
regulation of cytoplasmic transportGO:190364940.032
single organism metabolic processGO:00447102170.032
system processGO:00030081850.032
single organism nuclear importGO:190259330.032
positive regulation of epithelial cell migrationGO:001063420.032
biosynthetic processGO:00090582940.032
response to drugGO:004249330.031
cell morphogenesisGO:00009022890.031
regulation of protein targetingGO:190353320.031
response to stressGO:00069502630.031
transmission of nerve impulseGO:0019226190.031
maintenance of locationGO:005123540.030
nuclear transportGO:005116940.030
intracellular signal transductionGO:0035556850.030
ameboidal type cell migrationGO:00016671430.030
heart developmentGO:00075073130.030
regulation of primary metabolic processGO:00800903110.029
single fertilizationGO:000733830.029
protein targeting to nucleusGO:004474430.029
amine metabolic processGO:000930820.029
cellular response to molecule of bacterial originGO:007121930.028
membrane fusionGO:006102520.028
establishment of protein localization to organelleGO:007259440.028
blood vessel developmentGO:00015682460.028
brain developmentGO:00074202930.028
endocrine hormone secretionGO:006098620.028
regulation of nitrogen compound metabolic processGO:00511712510.028
cellular component biogenesisGO:00440851780.028
regulation of muscle contractionGO:000693730.027
leukocyte proliferationGO:007066110.027
positive regulation of i kappab kinase nf kappab signalingGO:004312330.027
regulation of developmental processGO:00507932470.027
negative regulation of cellular processGO:00485232830.026
neuronal action potentialGO:0019228180.026
negative regulation of response to cytokine stimulusGO:006076120.026
positive regulation of biological processGO:00485182530.026
regulation of blood pressureGO:000821710.026
endocrine processGO:005088620.026
neurological system processGO:0050877620.025
regulation of nucleocytoplasmic transportGO:004682220.025
cellular macromolecule biosynthetic processGO:00346452240.025
cell motilityGO:00488702440.025
cell surface receptor signaling pathwayGO:00071663250.025
negative regulation of protein localization to nucleusGO:190018120.025
regulation of inflammatory responseGO:005072720.025
nucleic acid templated transcriptionGO:00976591810.025
regulation of tube sizeGO:003515020.025
cell deathGO:00082191210.025
negative regulation of response to stimulusGO:00485851040.025
regulation of reproductive processGO:200024140.025
regulation of establishment of protein localizationGO:007020140.024
determination of heart left right asymmetryGO:00613711170.024
regulation of protein complex assemblyGO:004325430.024
deathGO:00162651210.024
cellular nitrogen compound metabolic processGO:00346412900.024
cell migrationGO:00164772370.024
cellular macromolecule metabolic processGO:00442603910.024
regulation of response to cytokine stimulusGO:006075930.024
nucleobase containing compound metabolic processGO:00061392740.024
organic cyclic compound metabolic processGO:19013603010.023
rna metabolic processGO:00160702190.023
regulation of circadian rhythmGO:004275240.023
nuclear importGO:005117030.023
cellular protein metabolic processGO:00442671290.023
signal transductionGO:00071654550.023
camera type eye developmentGO:00430102220.023
osteoclast differentiationGO:003031610.023
exocytosisGO:000688710.023
extrinsic apoptotic signaling pathway in absence of ligandGO:009719210.023
regulation of multicellular organismal developmentGO:20000262230.022
regulation of cell activationGO:005086510.022
regulation of synaptic plasticityGO:004816710.022
macromolecule biosynthetic processGO:00090592270.022
positive regulation of blood circulationGO:190352420.022
specification of symmetryGO:00097992040.022
meiotic chromosome segregationGO:004513230.022
stem cell maintenanceGO:001982740.022
positive regulation of immune effector processGO:000269930.022
regulation of cell shapeGO:000836010.022
regulation of cellular biosynthetic processGO:00313262450.021
positive regulation of cytoskeleton organizationGO:005149530.021
heart morphogenesisGO:00030071560.021
cellular response to organic substanceGO:00713101050.021
action potentialGO:0001508190.021
cytokinesisGO:000091030.021
cellular component morphogenesisGO:00329893360.021
rna biosynthetic processGO:00327741810.021
antimicrobial humoral responseGO:001973020.021
blood vessel morphogenesisGO:00485142160.021
negative regulation of cytokine mediated signaling pathwayGO:000196020.021
digestive system developmentGO:00551232890.021
cellular aromatic compound metabolic processGO:00067252950.021
organelle fusionGO:004828430.021
negative regulation of biological processGO:00485193040.020
regulation of cellular ketone metabolic processGO:001056570.020
multi organism processGO:00517041340.020
Mouse
positive regulation of cellular catabolic processGO:003133130.020
tube morphogenesisGO:00352393490.020
positive regulation of signalingGO:0023056560.020
positive regulation of secretionGO:005104710.020
cellular response to biotic stimulusGO:007121630.020
production of molecular mediator of immune responseGO:000244020.020
positive regulation of cellular processGO:00485222010.020
immune system developmentGO:00025201910.020
oxoacid metabolic processGO:0043436310.020
positive regulation of cell activationGO:005086710.020
meiosis iGO:000712710.019
positive regulation of catabolic processGO:000989640.019
response to other organismGO:0051707970.019
purine ribonucleoside monophosphate catabolic processGO:000916940.019
positive regulation of myeloid cell differentiationGO:004563920.019
response to woundingGO:00096111160.019
regulation of wound healingGO:006104120.019
regulation of rna biosynthetic processGO:20011412130.019
heterocycle biosynthetic processGO:00181302150.019
positive regulation of neuron deathGO:190121610.019
compound eye developmentGO:004874920.019
reactive nitrogen species metabolic processGO:200105700.018
female sex differentiationGO:004666040.018
cell projection organizationGO:00300302840.018
negative regulation of cell communicationGO:0010648960.018
regulation of membrane potentialGO:0042391230.018
organonitrogen compound metabolic processGO:1901564740.018
spindle assemblyGO:005122520.018
fatty acid biosynthetic processGO:000663340.018
regulation of metabolic processGO:00192223590.018
regionalizationGO:00030022740.018
cell part morphogenesisGO:00329902460.018
transcription dna templatedGO:00063511810.018
establishment of protein localization to plasma membraneGO:009000210.018
proteasome mediated ubiquitin dependent protein catabolic processGO:004316120.018
single organism transportGO:00447652060.018
regulation of striated muscle contractionGO:000694220.018
negative regulation of protein phosphorylationGO:000193340.018
cellular component disassemblyGO:002241110.018
regulation of cellular amine metabolic processGO:003323800.018
guanosine containing compound catabolic processGO:190106920.018
organic acid metabolic processGO:0006082310.017
positive regulation of neuron apoptotic processGO:004352510.017
dorsal ventral pattern formationGO:00099531250.017
negative regulation of multicellular organismal processGO:0051241690.017
cellular component assemblyGO:00226071700.017
sleepGO:003043110.017
regulation of protein catabolic processGO:004217610.017
axis specificationGO:0009798430.017
gtp catabolic processGO:000618420.017
regulation of synapse organizationGO:005080730.017
negative regulation of gene expressionGO:0010629650.017
regulation of rna metabolic processGO:00512522240.017
establishment of endothelial barrierGO:006102830.017
gene expressionGO:00104672520.017
regulation of steroid hormone secretionGO:200083110.017
regulation of cellular macromolecule biosynthetic processGO:20001122220.017
symbiosis encompassing mutualism through parasitismGO:004440340.017
smooth muscle contractionGO:000693920.017
regulation of production of molecular mediator of immune responseGO:000270010.016
phagocytosis engulfmentGO:000691110.016
cellular response to external stimulusGO:007149620.016
phosphorylationGO:0016310690.016
circadian sleep wake cycle sleepGO:005080210.016
single organism membrane fusionGO:004480120.016
hematopoietic or lymphoid organ developmentGO:00485341910.016
negative regulation of nuclear divisionGO:005178430.016
heterocycle metabolic processGO:00464832900.016
guanosine containing compound metabolic processGO:190106840.016
gtp metabolic processGO:004603940.016
synaptic growth at neuromuscular junctionGO:005112420.016
regulation of macromolecule metabolic processGO:00602553170.016
regulation of protein ubiquitinationGO:003139630.016
immune system processGO:00023762410.016
generation of neuronsGO:00486993850.016
ventricular cardiac muscle tissue developmentGO:000322930.016
single organism localizationGO:19025782250.016
regulation of peptidyl tyrosine phosphorylationGO:005073010.016
regulation of circadian sleep wake cycle sleepGO:004518710.016
neuron neuron synaptic transmissionGO:000727010.016
negative regulation of signal transductionGO:0009968940.016
regulation of sodium ion transportGO:000202820.016
carboxylic acid metabolic processGO:0019752220.015
toll like receptor signaling pathwayGO:000222440.015
vacuolar transportGO:000703420.015
gastrulationGO:00073692080.015
digestive tract morphogenesisGO:00485462310.015
extracellular matrix organizationGO:0030198270.015
peptide transportGO:001583310.015
regulation of cellular amino acid metabolic processGO:000652100.015
regulation of circadian sleep wake cycleGO:004274910.015
negative regulation of cytokine productionGO:000181810.015
cellular amino acid metabolic processGO:000652070.015
ubiquitin dependent protein catabolic processGO:000651130.015
regulation of blood coagulationGO:003019310.015
protein secretionGO:000930610.015
hemopoiesisGO:00300971830.015
transportGO:00068102200.015
proteasomal protein catabolic processGO:001049820.015
interspecies interaction between organismsGO:004441940.015
mononuclear cell proliferationGO:003294310.015
multicellular organismal signalingGO:0035637220.015
cell cycle g1 s phase transitionGO:004484310.015
cellular response to endogenous stimulusGO:0071495680.015
regulation of multicellular organism growthGO:004001440.015
lamellipodium assemblyGO:003003210.015
astrocyte differentiationGO:004870810.015
renal system developmentGO:0072001940.015
adult behaviorGO:003053420.015
regulation of blood vessel sizeGO:005088020.015
cellular response to oxygen levelsGO:007145310.015
organic substance biosynthetic processGO:19015762890.015
positive regulation of cell divisionGO:005178120.015
regulation of stem cell differentiationGO:200073640.014
negative regulation of signalingGO:0023057960.014
autophagyGO:000691440.014
myeloid cell differentiationGO:0030099860.014
negative regulation of protein transportGO:005122430.014
regulation of response to stressGO:0080134360.014
g protein coupled receptor signaling pathwayGO:0007186740.014
regulation of oxidative stress induced cell deathGO:190320120.014
retina development in camera type eyeGO:00600411460.014
regulation of macromolecule biosynthetic processGO:00105562250.014
regulation of cytokine mediated signaling pathwayGO:000195930.014
response to organic substanceGO:00100331530.014
steroid hormone secretionGO:003592910.014
cell projection morphogenesisGO:00488582440.014
signal transduction in absence of ligandGO:003803410.014
programmed cell deathGO:00125011190.014
positive regulation of purine nucleotide catabolic processGO:003312310.014
cytoplasm organizationGO:000702840.014
regulation of lipid transportGO:003236840.014
macromolecule modificationGO:00434121110.014
negative regulation of metabolic processGO:0009892860.014
regulation of oocyte developmentGO:006028130.014
cellular amine metabolic processGO:004410620.014
determination of bilateral symmetryGO:00098552040.014
germ line stem cell maintenanceGO:003071820.014
response to xenobiotic stimulusGO:0009410450.014
central nervous system developmentGO:00074173870.014
regulation of gene expressionGO:00104682650.014
internal protein amino acid acetylationGO:000647520.014
mitotic recombinationGO:000631220.013
negative regulation of nitrogen compound metabolic processGO:0051172590.013
regulation of cellular metabolic processGO:00313233200.013
digestive tract developmentGO:00485652650.013
regulation of cellular response to oxidative stressGO:190040720.013
regenerationGO:0031099910.013
positive regulation of apoptotic signaling pathwayGO:200123510.013
cellular ketone metabolic processGO:0042180110.013
response to virusGO:0009615210.013
negative regulation of i kappab kinase nf kappab signalingGO:004312410.013
cellular response to hypoxiaGO:007145610.013
regulation of exocytosisGO:001715710.013
positive regulation of extrinsic apoptotic signaling pathwayGO:200123810.013
regulation of jak stat cascadeGO:004642530.013
positive regulation of inflammatory responseGO:005072910.013
glial cell migrationGO:000834730.013
sprouting angiogenesisGO:0002040530.013
regulation of ion transmembrane transporter activityGO:003241220.013
negative regulation of intracellular transportGO:003238730.013
regulation of endothelial cell proliferationGO:000193610.013
cell death in response to oxidative stressGO:003647320.013
apoptotic processGO:00069151160.013
intestinal cholesterol absorptionGO:003029920.013
embryo development ending in birth or egg hatchingGO:00097922710.013
regulation of meiotic cell cycleGO:005144510.013
nitric oxide metabolic processGO:004620920.013
modification dependent macromolecule catabolic processGO:004363230.013
cellular protein modification processGO:00064641000.013
negative regulation of defense responseGO:003134820.013
positive regulation of secretion by cellGO:190353210.013
organic cyclic compound biosynthetic processGO:19013622230.013
female gonad developmentGO:000858540.013
rna localizationGO:000640340.013
positive regulation of epithelial cell differentiationGO:003085820.013
regulation of synapse assemblyGO:005196330.013
regulation of endocrine processGO:004406020.013
cell proliferationGO:0008283800.012
response to uvGO:000941130.012
lymphocyte proliferationGO:004665110.012
regulation of myotube differentiationGO:001083020.012
regulation of nucleoside metabolic processGO:000911820.012
positive regulation of cellular amino acid metabolic processGO:004576400.012
regulation of cellular component organizationGO:0051128860.012
response to external biotic stimulusGO:0043207970.012
positive regulation of biosynthetic processGO:0009891680.012
response to hexoseGO:000974630.012
growthGO:00400071740.012
ovulation cycleGO:004269820.012
organelle organizationGO:00069962270.012
embryonic skeletal system developmentGO:0048706970.012
ventricular cardiac muscle tissue morphogenesisGO:005501020.012
regulation of synaptic growth at neuromuscular junctionGO:000858210.012
epithelial tube morphogenesisGO:00605621480.012
multicellular organism growthGO:003526440.012
positive regulation of protein complex assemblyGO:003133420.012
determination of ventral identityGO:0048264210.012
embryonic organ morphogenesisGO:00485622740.012
stem cell divisionGO:001714510.012
positive regulation of nitrogen compound metabolic processGO:0051173690.012
protein homooligomerizationGO:005126030.012
agingGO:000756820.012
enzyme linked receptor protein signaling pathwayGO:00071671060.012
mitochondrion organizationGO:000700540.012
mitotic cell cycleGO:0000278640.012
vasculature developmentGO:00019442780.012
eye developmentGO:00016542770.012
developmental programmed cell deathGO:001062340.012
phosphorus metabolic processGO:00067931090.012
microtubule organizing center organizationGO:003102310.012
single organism reproductive processGO:0044702400.012
Mouse
positive regulation of cellular amine metabolic processGO:003324000.012
extrinsic apoptotic signaling pathwayGO:009719130.012
negative regulation of cellular metabolic processGO:0031324770.012
negative regulation of stem cell differentiationGO:200073720.012
angiogenesisGO:00015251580.012
protein heterooligomerizationGO:005129110.012
response to lipidGO:0033993600.012
regulation of transcription dna templatedGO:00063552130.012
modification dependent protein catabolic processGO:001994130.012
positive regulation of endothelial cell migrationGO:001059520.011
response to nutrientGO:000758430.011
regulation of nucleic acid templated transcriptionGO:19035062130.011
cellular response to stressGO:0033554620.011
determination of left right symmetryGO:00073681790.011
apoptotic process involved in developmentGO:190274220.011
regulation of response to oxidative stressGO:190288220.011
peptide metabolic processGO:000651810.011
muscle organ developmentGO:00075171010.011
golgi vesicle transportGO:004819330.011
apoptotic process involved in morphogenesisGO:006056120.011
synaptic vesicle localizationGO:009747910.011
determination of dorsal ventral asymmetryGO:0048262340.011
response to monosaccharideGO:003428430.011
endosomal transportGO:001619720.011
skeletal system developmentGO:00015011810.011
neuron developmentGO:00486662620.011
intracellular mrna localizationGO:000829810.011
cellular response to extracellular stimulusGO:003166820.011
kidney developmentGO:0001822920.011
positive regulation of nucleotide catabolic processGO:003081310.011
leukocyte mediated cytotoxicityGO:000190910.011
cognitionGO:005089010.011
reactive oxygen species biosynthetic processGO:190340910.011
positive regulation of multi organism processGO:004390230.011
glomerulus developmentGO:0032835270.011
viral processGO:001603210.011
nucleic acid metabolic processGO:00903042440.011
nucleoside monophosphate catabolic processGO:000912540.011
positive regulation of leukocyte mediated immunityGO:000270510.011
defense response to fungusGO:005083220.011
response to oxygen containing compoundGO:1901700550.011
cell cell recognitionGO:000998810.011
negative regulation of reproductive processGO:200024230.011
energy reserve metabolic processGO:000611220.011
embryonic organ developmentGO:00485683810.011
regulation of protein modification by small protein conjugation or removalGO:190332030.011
establishment of localizationGO:00512342440.011
negative regulation of multi organism processGO:004390130.011
chordate embryonic developmentGO:00430092710.011
rna export from nucleusGO:000640510.011
regulation of metal ion transportGO:001095940.011
positive regulation of muscle cell differentiationGO:005114910.011
regulation of response to biotic stimulusGO:000283120.011
regulation of interferon gamma mediated signaling pathwayGO:006033410.010
germ line stem cell divisionGO:004207810.010
g1 s transition of mitotic cell cycleGO:000008210.010
dna templated transcription elongationGO:000635430.010
renal tubule morphogenesisGO:006133310.010
fertilizationGO:000956630.010
multicellular organismal macromolecule metabolic processGO:004425920.010
positive regulation of macromolecule biosynthetic processGO:0010557590.010
regulation of transporter activityGO:003240920.010
organic substance transportGO:0071702580.010
single organism biosynthetic processGO:0044711710.010
zymogen activationGO:003163830.010
regulation of locomotionGO:0040012550.010
regulation of gtpase activityGO:004308720.010
protein phosphorylationGO:0006468470.010
regulation of nucleobase containing compound metabolic processGO:00192192500.010
neuron differentiationGO:00301823530.010
superoxide metabolic processGO:000680120.010
regulation of nucleotide catabolic processGO:003081120.010
phosphate containing compound metabolic processGO:00067961080.010
positive regulation of synapse assemblyGO:005196510.010
regulation of protein bindingGO:004339330.010
membrane invaginationGO:001032410.010
response to vitaminGO:003327330.010
purine nucleoside monophosphate catabolic processGO:000912840.010
positive regulation of peptidyl tyrosine phosphorylationGO:005073110.010
regulation of autophagyGO:001050630.010
negative regulation of protein import into nucleusGO:004230820.010

ptgis disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.022
musculoskeletal system diseaseDOID:1700.021
connective tissue diseaseDOID:6500.016
nervous system diseaseDOID:86300.015
myopathyDOID:42300.014
cardiovascular system diseaseDOID:128700.014
muscle tissue diseaseDOID:6600.014
cardiomyopathyDOID:005070000.014
intrinsic cardiomyopathyDOID:006003600.014
muscular diseaseDOID:008000000.014
heart diseaseDOID:11400.014