IMP: Integrative Multi-species Prediction

Danio rerio

9 known processes

rps15

ribosomal protein S15

(Aliases: zgc:92743,wu:fa99b07,MGC103714,zgc:103714,wu:fa93f04)

ZFIN: ZDB-GENE-030131-9092
Ensembl: ENSDARG00000070849
Entrez: 337148
UniProtKB: Q6Q421

Process Predictions
Disease Predictions

rps15 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
larval development	GO:0002164	2	0.939	Worm
ribosomal small subunit biogenesis	GO:0042274	2	0.552	Human
maturation of ssu rrna from tricistronic rrna transcript ssu rrna 5 8s rrna lsu rrna	GO:0000462	1	0.388
embryo development ending in birth or egg hatching	GO:0009792	271	0.330	Worm
nucleobase containing compound metabolic process	GO:0006139	274	0.307	Human
ribonucleoprotein complex biogenesis	GO:0022613	13	0.296	Human Yeast
rna processing	GO:0006396	25	0.271	Human
maturation of ssu rrna	GO:0030490	1	0.241
ncrna metabolic process	GO:0034660	12	0.228	Human
mitotic cell cycle	GO:0000278	64	0.196	Fly
centrosome cycle	GO:0007098	1	0.189
ribosome assembly	GO:0042255	1	0.167
macromolecular complex subunit organization	GO:0043933	74	0.162	Fly
aging	GO:0007568	2	0.162	Worm
heterocycle metabolic process	GO:0046483	290	0.158	Human
regulation of multicellular organism growth	GO:0040014	4	0.148
biosynthetic process	GO:0009058	294	0.136	Worm
organic cyclic compound metabolic process	GO:1901360	301	0.127	Human
ncrna processing	GO:0034470	8	0.115	Human
cellular macromolecule metabolic process	GO:0044260	391	0.114	Human Worm
rrna metabolic process	GO:0016072	8	0.113	Human
microtubule organizing center organization	GO:0031023	1	0.104
multicellular organism growth	GO:0035264	4	0.103
gene expression	GO:0010467	252	0.103	Human Worm
centrosome organization	GO:0051297	1	0.102
mitotic cell cycle process	GO:1903047	48	0.100	Fly
cytoskeleton organization	GO:0007010	96	0.097	Fly
reproduction	GO:0000003	40	0.091	Worm
cellular nitrogen compound metabolic process	GO:0034641	290	0.091	Human
nucleic acid metabolic process	GO:0090304	244	0.085	Human
homeostasis of number of cells	GO:0048872	62	0.080
hematopoietic or lymphoid organ development	GO:0048534	191	0.080
rrna processing	GO:0006364	7	0.080	Human
rna metabolic process	GO:0016070	219	0.079	Human
regulation of biological quality	GO:0065008	263	0.078
immune system process	GO:0002376	241	0.078
centrosome duplication	GO:0051298	1	0.074
microtubule based process	GO:0007017	60	0.072	Fly
response to transition metal nanoparticle	GO:1990267	28	0.072
homeostatic process	GO:0042592	142	0.072
central nervous system development	GO:0007417	387	0.071
apoptotic process	GO:0006915	116	0.067	Worm
hemopoiesis	GO:0030097	183	0.066
organelle organization	GO:0006996	227	0.062	Fly
meiotic cell cycle process	GO:1903046	3	0.062
chordate embryonic development	GO:0043009	271	0.059
maintenance of location	GO:0051235	4	0.057
myeloid cell homeostasis	GO:0002262	56	0.057
brain development	GO:0007420	293	0.057
somitogenesis	GO:0001756	87	0.056
cellular component biogenesis	GO:0044085	178	0.055	Human Yeast
mitotic dna integrity checkpoint	GO:0044774	4	0.052
segmentation	GO:0035282	97	0.052
sexual reproduction	GO:0019953	36	0.045
cell cycle process	GO:0022402	53	0.045	Fly
nitrogen compound metabolic process	GO:0006807	319	0.043	Human
immune system development	GO:0002520	191	0.042
oocyte anterior posterior axis specification	GO:0007314	4	0.042
erythrocyte homeostasis	GO:0034101	55	0.042
cellular macromolecule biosynthetic process	GO:0034645	224	0.039	Worm
erythrocyte development	GO:0048821	24	0.039
cell cycle	GO:0007049	93	0.038	Fly
regulation of metabolic process	GO:0019222	359	0.037
signal transduction	GO:0007165	455	0.036
lipid storage	GO:0019915	1	0.036
single fertilization	GO:0007338	3	0.035
mesenchyme development	GO:0060485	127	0.034
localization of cell	GO:0051674	244	0.032
cellular aromatic compound metabolic process	GO:0006725	295	0.032	Human
positive regulation of biological process	GO:0048518	253	0.032
nucleocytoplasmic transport	GO:0006913	4	0.031	Human Yeast
organelle assembly	GO:0070925	110	0.030
response to chemical	GO:0042221	320	0.029
regulation of cell cycle	GO:0051726	52	0.029
erythrocyte differentiation	GO:0030218	54	0.029
meiotic nuclear division	GO:0007126	4	0.028
cellular protein metabolic process	GO:0044267	129	0.028	Worm
single organism organelle organization	GO:1902589	199	0.028	Fly
cell death	GO:0008219	121	0.027	Worm
multicellular organismal reproductive process	GO:0048609	35	0.026
microtubule cytoskeleton organization	GO:0000226	33	0.026	Fly
cellular biosynthetic process	GO:0044249	286	0.026	Worm
cellular component assembly	GO:0022607	170	0.025
myeloid cell differentiation	GO:0030099	86	0.025
response to metal ion	GO:0010038	34	0.025
ribosome biogenesis	GO:0042254	9	0.024	Human Yeast
regulation of macromolecule biosynthetic process	GO:0010556	225	0.024
ribonucleoprotein complex assembly	GO:0022618	5	0.024
cell surface receptor signaling pathway	GO:0007166	325	0.024
anterior posterior pattern specification	GO:0009952	152	0.024
protein complex subunit organization	GO:0071822	46	0.024	Fly
macromolecular complex assembly	GO:0065003	35	0.023
organic substance biosynthetic process	GO:1901576	289	0.023	Worm
single organism localization	GO:1902578	225	0.023	Human Yeast
regulation of developmental process	GO:0050793	247	0.023
regulation of multicellular organismal development	GO:2000026	223	0.023
macromolecule biosynthetic process	GO:0009059	227	0.023	Worm
nuclear transport	GO:0051169	4	0.022	Human Yeast
establishment of localization	GO:0051234	244	0.022	Human Yeast
cell migration	GO:0016477	237	0.021
cellular component movement	GO:0006928	335	0.021
cellular amine metabolic process	GO:0044106	2	0.021
gtp metabolic process	GO:0046039	4	0.021
single organism reproductive process	GO:0044702	40	0.020
oxoacid metabolic process	GO:0043436	31	0.020
pole plasm assembly	GO:0007315	4	0.020
myeloid cell development	GO:0061515	32	0.020
developmental growth	GO:0048589	166	0.020
programmed cell death	GO:0012501	119	0.019	Worm
cell morphogenesis involved in differentiation	GO:0000904	195	0.019
locomotion	GO:0040011	313	0.019
head development	GO:0060322	303	0.019
regionalization	GO:0003002	274	0.019
amine metabolic process	GO:0009308	2	0.018
death	GO:0016265	121	0.018	Worm
regulation of establishment of protein localization	GO:0070201	4	0.017
carboxylic acid metabolic process	GO:0019752	22	0.017
positive regulation of cell cycle	GO:0045787	3	0.017
negative regulation of kinase activity	GO:0033673	4	0.016
protein complex disassembly	GO:0043241	1	0.016
fertilization	GO:0009566	3	0.016
somite development	GO:0061053	96	0.016
regulation of gene expression	GO:0010468	265	0.015
protein metabolic process	GO:0019538	183	0.015	Worm
negative regulation of biological process	GO:0048519	304	0.014
regulation of protein localization to nucleus	GO:1900180	2	0.014
meiotic chromosome segregation	GO:0045132	3	0.014
cellular amino acid metabolic process	GO:0006520	7	0.014
regulation of purine nucleotide catabolic process	GO:0033121	2	0.014
transport	GO:0006810	220	0.014	Human Yeast
multi organism process	GO:0051704	134	0.014
cell motility	GO:0048870	244	0.014
protein import	GO:0017038	3	0.013
regulation of protein complex disassembly	GO:0043244	1	0.013
pancreas development	GO:0031016	84	0.013
cellular component morphogenesis	GO:0032989	336	0.013
positive regulation of transport	GO:0051050	2	0.013
regulation of cellular amino acid metabolic process	GO:0006521	0	0.013
growth	GO:0040007	174	0.013
regulation of biosynthetic process	GO:0009889	250	0.013
positive regulation of cellular process	GO:0048522	201	0.013
morphogenesis of an epithelium	GO:0002009	333	0.013
regulation of nucleoside metabolic process	GO:0009118	2	0.013
regulation of cellular biosynthetic process	GO:0031326	245	0.013
regulation of cytoplasmic transport	GO:1903649	4	0.012
regulation of multicellular organismal process	GO:0051239	277	0.012
protein localization to nucleus	GO:0034504	3	0.012
cellular response to organic substance	GO:0071310	105	0.012
primary neural tube formation	GO:0014020	1	0.012
regulation of rna metabolic process	GO:0051252	224	0.012
cellular ketone metabolic process	GO:0042180	11	0.012
nucleic acid transport	GO:0050657	2	0.012	Yeast
regulation of cell communication	GO:0010646	232	0.012
response to stress	GO:0006950	263	0.012	Worm
organonitrogen compound metabolic process	GO:1901564	74	0.012
cell morphogenesis	GO:0000902	289	0.012
positive regulation of cellular catabolic process	GO:0031331	3	0.012
guanosine containing compound metabolic process	GO:1901068	4	0.012
angiogenesis	GO:0001525	158	0.012
cell part morphogenesis	GO:0032990	246	0.011
ion transport	GO:0006811	114	0.011
blood vessel development	GO:0001568	246	0.011
response to organic substance	GO:0010033	153	0.011
positive regulation of nucleotide catabolic process	GO:0030813	1	0.011
establishment of protein localization to organelle	GO:0072594	4	0.011
cell projection organization	GO:0030030	284	0.011
regulation of transmembrane transporter activity	GO:0022898	2	0.011
intrinsic apoptotic signaling pathway by p53 class mediator	GO:0072332	9	0.011
organic acid metabolic process	GO:0006082	31	0.011
regulation of cellular macromolecule biosynthetic process	GO:2000112	222	0.011
positive regulation of developmental process	GO:0051094	50	0.011
cell projection morphogenesis	GO:0048858	244	0.011
spindle organization	GO:0007051	5	0.011	Fly
negative regulation of protein kinase activity	GO:0006469	4	0.010
small molecule metabolic process	GO:0044281	77	0.010
vasculature development	GO:0001944	278	0.010
transcription dna templated	GO:0006351	181	0.010

rps15 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.309
immune system disease	DOID:2914	0.309
aplastic anemia	DOID:12449	0.304
hematopoietic system disease	DOID:74	0.304
bone marrow disease	DOID:4961	0.304
anemia	DOID:2355	0.304
congenital hypoplastic anemia	DOID:1342	0.155
diamond blackfan anemia	DOID:1339	0.108
cardiovascular system disease	DOID:1287	0.012

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