IMP: Integrative Multi-species Prediction

Danio rerio

60 known processes

gbx1

gastrulation brain homeobox 1

(Aliases: cb619,wu:fj77a06,fj77a06)

Entrez: 142985
ZFIN: ZDB-GENE-020117-2
Ensembl: ENSDARG00000071418
UniProtKB: Q90ZB2

Process Predictions
Disease Predictions

gbx1 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
hindbrain morphogenesis	GO:0021575	22	0.932
organic cyclic compound metabolic process	GO:1901360	301	0.931	Fly
cellular nitrogen compound metabolic process	GO:0034641	290	0.924	Fly
regulation of nucleobase containing compound metabolic process	GO:0019219	250	0.913	Fly
macromolecule biosynthetic process	GO:0009059	227	0.907	Fly
regulation of primary metabolic process	GO:0080090	311	0.894	Fly
brain development	GO:0007420	293	0.894
head development	GO:0060322	303	0.886
hindbrain development	GO:0030902	91	0.886	Zebrafish
aromatic compound biosynthetic process	GO:0019438	217	0.870	Fly
rna biosynthetic process	GO:0032774	181	0.851	Fly
regulation of nucleic acid templated transcription	GO:1903506	213	0.830	Fly
regulation of macromolecule biosynthetic process	GO:0010556	225	0.784	Fly
sensory organ morphogenesis	GO:0090596	200	0.768
nucleic acid metabolic process	GO:0090304	244	0.764	Fly
cellular macromolecule biosynthetic process	GO:0034645	224	0.756	Fly
sensory organ development	GO:0007423	393	0.746
cellular macromolecule metabolic process	GO:0044260	391	0.729	Fly
regulation of nitrogen compound metabolic process	GO:0051171	251	0.721	Fly
regulation of metabolic process	GO:0019222	359	0.714	Fly
fourth ventricle development	GO:0021592	8	0.706
regionalization	GO:0003002	274	0.702
regulation of biosynthetic process	GO:0009889	250	0.690	Fly
regulation of rna biosynthetic process	GO:2001141	213	0.690	Fly
camera type eye development	GO:0043010	222	0.688
embryonic organ development	GO:0048568	381	0.660
camera type eye morphogenesis	GO:0048593	108	0.645
organic cyclic compound biosynthetic process	GO:1901362	223	0.644	Fly
spinal cord association neuron differentiation	GO:0021527	1	0.635
digestive system development	GO:0055123	289	0.630
nucleobase containing compound biosynthetic process	GO:0034654	205	0.622	Fly
ear morphogenesis	GO:0042471	64	0.588
regulation of rna metabolic process	GO:0051252	224	0.581	Fly
cell motility	GO:0048870	244	0.576
regulation of transcription from rna polymerase ii promoter	GO:0006357	114	0.576
rostrocaudal neural tube patterning	GO:0021903	29	0.576
retina development in camera type eye	GO:0060041	146	0.574
regulation of cellular macromolecule biosynthetic process	GO:2000112	222	0.569	Fly
cellular biosynthetic process	GO:0044249	286	0.564	Fly
regulation of response to stimulus	GO:0048583	269	0.558
neuromast mantle cell differentiation	GO:0048888	1	0.552
digestive tract morphogenesis	GO:0048546	231	0.550
regulation of gene expression	GO:0010468	265	0.539	Fly
heart morphogenesis	GO:0003007	156	0.532
cell migration	GO:0016477	237	0.527
pancreas development	GO:0031016	84	0.524	Zebrafish
pons development	GO:0021548	11	0.518
heterocycle metabolic process	GO:0046483	290	0.512	Fly
cell fate specification	GO:0001708	68	0.506	Zebrafish
rhombomere formation	GO:0021594	12	0.505
embryonic organ morphogenesis	GO:0048562	274	0.483
nucleic acid templated transcription	GO:0097659	181	0.476	Fly
regulation of transcription dna templated	GO:0006355	213	0.475	Fly
heterocycle biosynthetic process	GO:0018130	215	0.472	Fly
metencephalon development	GO:0022037	27	0.469
phosphorus metabolic process	GO:0006793	109	0.469
retina morphogenesis in camera type eye	GO:0060042	79	0.469
eye development	GO:0001654	277	0.468
facial nucleus development	GO:0021754	7	0.458
tube morphogenesis	GO:0035239	349	0.448
positive regulation of cellular metabolic process	GO:0031325	94	0.448
pancreatic a cell development	GO:0003322	2	0.442
mechanoreceptor differentiation	GO:0042490	37	0.441
central nervous system development	GO:0007417	387	0.430
positive regulation of nitrogen compound metabolic process	GO:0051173	69	0.422
nucleobase containing compound metabolic process	GO:0006139	274	0.413	Fly
rhombomere development	GO:0021546	19	0.400
cellular nitrogen compound biosynthetic process	GO:0044271	218	0.393	Fly
cellular aromatic compound metabolic process	GO:0006725	295	0.387	Fly
organic substance biosynthetic process	GO:1901576	289	0.386	Fly
heart development	GO:0007507	313	0.381
oligodendrocyte differentiation	GO:0048709	23	0.378
regulation of macromolecule metabolic process	GO:0060255	317	0.377	Fly
determination of heart left right asymmetry	GO:0061371	117	0.369
embryonic eye morphogenesis	GO:0048048	30	0.363
transcription dna templated	GO:0006351	181	0.361	Fly
regulation of cellular metabolic process	GO:0031323	320	0.357	Fly
pectoral fin morphogenesis	GO:0035138	29	0.337
abducens nucleus development	GO:0021742	2	0.328
columnar cuboidal epithelial cell differentiation	GO:0002065	38	0.324	Zebrafish
regulation of multicellular organismal process	GO:0051239	277	0.315
eye morphogenesis	GO:0048592	144	0.314
rhombomere morphogenesis	GO:0021593	17	0.313
enzyme linked receptor protein signaling pathway	GO:0007167	106	0.312
negative regulation of cellular process	GO:0048523	283	0.309
somitogenesis	GO:0001756	87	0.294
central nervous system neuron differentiation	GO:0021953	74	0.275	Zebrafish Mouse
positive regulation of gene expression	GO:0010628	71	0.273
regulation of neural precursor cell proliferation	GO:2000177	3	0.265
ventral spinal cord development	GO:0021517	35	0.260	Zebrafish Mouse
rna metabolic process	GO:0016070	219	0.259	Fly
inner ear development	GO:0048839	126	0.255
dorsal ventral pattern formation	GO:0009953	125	0.250
neuron differentiation	GO:0030182	353	0.237	Zebrafish Mouse
ventricular system development	GO:0021591	12	0.237
otic vesicle development	GO:0071599	42	0.235
anterior posterior pattern specification	GO:0009952	152	0.234
spinal cord motor neuron differentiation	GO:0021522	26	0.234	Zebrafish Mouse
embryonic camera type eye development	GO:0031076	29	0.229
ear development	GO:0043583	127	0.224
regulation of cellular biosynthetic process	GO:0031326	245	0.223	Fly
positive regulation of biological process	GO:0048518	253	0.223
neural tube patterning	GO:0021532	33	0.222
ventral spinal cord interneuron differentiation	GO:0021514	12	0.212
diencephalon development	GO:0021536	58	0.208
negative regulation of biological process	GO:0048519	304	0.207
positive regulation of rna metabolic process	GO:0051254	59	0.205
neuron fate specification	GO:0048665	20	0.204	Zebrafish
neural nucleus development	GO:0048857	15	0.203
eye photoreceptor cell development	GO:0042462	30	0.203
cell differentiation in spinal cord	GO:0021515	40	0.201	Zebrafish Mouse
positive regulation of macromolecule metabolic process	GO:0010604	93	0.199
response to chemical	GO:0042221	320	0.195	Mouse
neuron fate commitment	GO:0048663	26	0.193	Zebrafish Mouse
pectoral fin development	GO:0033339	50	0.190
generation of neurons	GO:0048699	385	0.190	Zebrafish Mouse
positive regulation of metabolic process	GO:0009893	108	0.183
morphogenesis of an epithelium	GO:0002009	333	0.182
embryonic camera type eye formation	GO:0060900	10	0.179
midbrain hindbrain boundary development	GO:0030917	23	0.179
positive regulation of cellular process	GO:0048522	201	0.179
negative regulation of transcription dna templated	GO:0045892	45	0.178
cellular component morphogenesis	GO:0032989	336	0.177	Mouse
gene expression	GO:0010467	252	0.176	Fly
otic vesicle morphogenesis	GO:0071600	34	0.176
positive regulation of nucleic acid templated transcription	GO:1903508	57	0.173
pancreatic d cell differentiation	GO:0003311	2	0.173
ectodermal placode morphogenesis	GO:0071697	32	0.168
forebrain anterior posterior pattern specification	GO:0021797	3	0.166
cell fate commitment	GO:0045165	99	0.164	Zebrafish Mouse
positive regulation of macromolecule biosynthetic process	GO:0010557	59	0.163
nitrogen compound metabolic process	GO:0006807	319	0.163	Fly
eye photoreceptor cell differentiation	GO:0001754	45	0.162
neural plate pattern specification	GO:0060896	12	0.162
convergent extension involved in gastrulation	GO:0060027	71	0.160
signal transduction	GO:0007165	455	0.153
retina layer formation	GO:0010842	24	0.153
cellular component movement	GO:0006928	335	0.146	Mouse
neuromast development	GO:0048884	46	0.145
lateral line system development	GO:0048925	76	0.141
digestive tract development	GO:0048565	265	0.140
intracellular receptor signaling pathway	GO:0030522	30	0.139
glomerulus development	GO:0032835	27	0.139
auditory receptor cell development	GO:0060117	8	0.136
posterior lateral line neuromast mantle cell differentiation	GO:0048924	1	0.134
mammillary body development	GO:0021767	4	0.134
transcription from rna polymerase ii promoter	GO:0006366	80	0.133
rhombomere 4 development	GO:0021570	5	0.133
eye field cell fate commitment involved in camera type eye formation	GO:0060898	3	0.131
pronephros development	GO:0048793	69	0.129
negative regulation of cellular biosynthetic process	GO:0031327	55	0.126
negative regulation of nitrogen compound metabolic process	GO:0051172	59	0.126
otic placode formation	GO:0043049	23	0.125
regulation of signal transduction	GO:0009966	225	0.125
taxis	GO:0042330	109	0.124	Mouse
response to stress	GO:0006950	263	0.122
negative regulation of gene expression	GO:0010629	65	0.121
cell projection morphogenesis	GO:0048858	244	0.121	Mouse
gastrulation	GO:0007369	208	0.117
regulation of cell communication	GO:0010646	232	0.117
somite development	GO:0061053	96	0.117
cell differentiation in hindbrain	GO:0021533	5	0.116
skin development	GO:0043588	54	0.114
biosynthetic process	GO:0009058	294	0.114	Fly
specification of symmetry	GO:0009799	204	0.112
larval development	GO:0002164	2	0.112
epidermal cell differentiation	GO:0009913	36	0.112
locomotion	GO:0040011	313	0.112	Mouse
ectoderm formation	GO:0001705	2	0.111
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	22	0.110
endocrine pancreas development	GO:0031018	27	0.109	Zebrafish
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	48	0.109
fin morphogenesis	GO:0033334	53	0.109
ectodermal placode formation	GO:0060788	26	0.108
epidermal cell fate specification	GO:0009957	4	0.107
response to organic substance	GO:0010033	153	0.107
oligodendrocyte cell fate specification	GO:0021778	4	0.107
single organism localization	GO:1902578	225	0.104
epidermis development	GO:0008544	48	0.104
protein localization to nucleus	GO:0034504	3	0.103
notochord development	GO:0030903	54	0.103
endocrine system development	GO:0035270	65	0.103	Zebrafish
response to external stimulus	GO:0009605	264	0.102	Mouse
maintenance of location	GO:0051235	4	0.101
stem cell fate commitment	GO:0048865	1	0.100
negative regulation of metabolic process	GO:0009892	86	0.099
negative regulation of cellular metabolic process	GO:0031324	77	0.098
negative regulation of macromolecule metabolic process	GO:0010605	76	0.098
cell proliferation in hindbrain	GO:0021534	4	0.098
neuroblast proliferation	GO:0007405	2	0.097
positive regulation of biosynthetic process	GO:0009891	68	0.097
neuron development	GO:0048666	262	0.097	Mouse
localization of cell	GO:0051674	244	0.097
anterior head development	GO:0097065	2	0.095
axon development	GO:0061564	166	0.094	Mouse
determination of bilateral symmetry	GO:0009855	204	0.092
regulation of molecular function	GO:0065009	70	0.091
nucleocytoplasmic transport	GO:0006913	4	0.091
blood vessel development	GO:0001568	246	0.090
response to endogenous stimulus	GO:0009719	83	0.089
determination of left right symmetry	GO:0007368	179	0.089
chordate embryonic development	GO:0043009	271	0.086
primary neural tube formation	GO:0014020	1	0.085
positive regulation of nucleobase containing compound metabolic process	GO:0045935	69	0.084
ventral spinal cord interneuron fate commitment	GO:0060579	3	0.084
negative regulation of stem cell differentiation	GO:2000737	2	0.083
cell morphogenesis involved in differentiation	GO:0000904	195	0.083	Mouse
negative regulation of nucleobase containing compound metabolic process	GO:0045934	59	0.082
appendage morphogenesis	GO:0035107	56	0.082
axonogenesis	GO:0007409	152	0.082	Mouse
cellular response to endogenous stimulus	GO:0071495	68	0.081
negative regulation of signal transduction	GO:0009968	94	0.081
protein import into nucleus	GO:0006606	3	0.080
inner ear morphogenesis	GO:0042472	63	0.080
mesenchymal cell differentiation	GO:0048762	87	0.080
regulation of anterior head development	GO:2000742	2	0.079
positive regulation of rna biosynthetic process	GO:1902680	57	0.078
sensory system development	GO:0048880	76	0.078
dna templated transcription initiation	GO:0006352	1	0.078
retinal ganglion cell axon guidance	GO:0031290	35	0.077
vasculature development	GO:0001944	278	0.076
neural tube development	GO:0021915	62	0.076
lateral line ganglion development	GO:0048890	2	0.076
cerebellum morphogenesis	GO:0021587	10	0.075
regulation of nervous system development	GO:0051960	90	0.075	Fly
immune system process	GO:0002376	241	0.075
negative regulation of rna metabolic process	GO:0051253	48	0.074
regulation of locomotion	GO:0040012	55	0.073
nerve development	GO:0021675	45	0.073
type b pancreatic cell development	GO:0003323	4	0.073
nuclear import	GO:0051170	3	0.072
otolith development	GO:0048840	32	0.072
regulation of endodermal cell fate specification	GO:0042663	15	0.072
circulatory system process	GO:0003013	87	0.072
positive regulation of cellular biosynthetic process	GO:0031328	68	0.072
blood circulation	GO:0008015	87	0.072
negative regulation of gliogenesis	GO:0014014	1	0.071
regulation of inner ear receptor cell differentiation	GO:2000980	1	0.071
embryonic heart tube morphogenesis	GO:0003143	108	0.071
neural plate anterior posterior regionalization	GO:0021999	8	0.070
regulation of wnt signaling pathway	GO:0030111	53	0.069
mesenchymal cell development	GO:0014031	78	0.069
convergent extension	GO:0060026	118	0.069
embryonic cranial skeleton morphogenesis	GO:0048701	90	0.068
skeletal system development	GO:0001501	181	0.067
regulation of signaling	GO:0023051	235	0.067
nephron development	GO:0072006	31	0.067
pronephric nephron development	GO:0039019	14	0.067
cell death	GO:0008219	121	0.066
ameboidal type cell migration	GO:0001667	143	0.066
aging	GO:0007568	2	0.066
cellular response to growth factor stimulus	GO:0071363	39	0.066
anterior posterior axis specification	GO:0009948	20	0.066
angiogenesis	GO:0001525	158	0.065
regulation of establishment of protein localization	GO:0070201	4	0.065
pituitary gland development	GO:0021983	16	0.065
ectoderm development	GO:0007398	9	0.065
neural retina development	GO:0003407	49	0.065
regulation of localization	GO:0032879	104	0.065
cell part morphogenesis	GO:0032990	246	0.064	Mouse
cerebellum development	GO:0021549	17	0.064
stem cell differentiation	GO:0048863	117	0.064
cellular protein modification process	GO:0006464	100	0.063
embryonic appendage morphogenesis	GO:0035113	30	0.063
rhombomere 5 development	GO:0021571	4	0.063
negative regulation of nucleic acid templated transcription	GO:1903507	45	0.062
cell migration involved in gastrulation	GO:0042074	79	0.061
regulation of cell differentiation	GO:0045595	142	0.059
spinal cord development	GO:0021510	46	0.059	Zebrafish Mouse
cardiocyte differentiation	GO:0035051	44	0.059
axon guidance	GO:0007411	86	0.058	Mouse
regulation of cellular response to growth factor stimulus	GO:0090287	35	0.058
rhombomere 4 morphogenesis	GO:0021661	5	0.058
multicellular organism growth	GO:0035264	4	0.058
lateral line development	GO:0048882	66	0.058
kupffer s vesicle development	GO:0070121	50	0.057
epithelial cell morphogenesis	GO:0003382	2	0.057
photoreceptor cell fate commitment	GO:0046552	1	0.056
midbrain development	GO:0030901	28	0.056
chemotaxis	GO:0006935	104	0.056	Mouse
negative regulation of cell development	GO:0010721	26	0.056
regulation of cellular protein metabolic process	GO:0032268	52	0.056
optic placode formation	GO:0001743	4	0.055
rhombomere boundary formation	GO:0021654	10	0.055
cartilage development involved in endochondral bone morphogenesis	GO:0060351	8	0.054
gland development	GO:0048732	143	0.054
positive regulation of response to stimulus	GO:0048584	80	0.053
otolith morphogenesis	GO:0032474	8	0.053
determination of left right asymmetry in lateral mesoderm	GO:0003140	20	0.053
stem cell proliferation	GO:0072089	4	0.052
hepaticobiliary system development	GO:0061008	98	0.051
heart process	GO:0003015	71	0.051
hair cell differentiation	GO:0035315	32	0.051
optic placode formation involved in camera type eye formation	GO:0046619	3	0.050
positive regulation of transcription dna templated	GO:0045893	57	0.050
embryonic skeletal system development	GO:0048706	97	0.050
single organism cellular localization	GO:1902580	46	0.049
blood vessel morphogenesis	GO:0048514	216	0.049
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	68	0.049
cellular localization	GO:0051641	97	0.049
negative regulation of rna biosynthetic process	GO:1902679	45	0.048
protein phosphorylation	GO:0006468	47	0.048
motor neuron axon guidance	GO:0008045	23	0.048
stem cell fate determination	GO:0048867	1	0.048
macromolecule modification	GO:0043412	111	0.048
forebrain neuron fate commitment	GO:0021877	1	0.047
negative regulation of multicellular organismal process	GO:0051241	69	0.047
positive regulation of catabolic process	GO:0009896	4	0.047
phosphate containing compound metabolic process	GO:0006796	108	0.047
single organism organelle organization	GO:1902589	199	0.047
posterior lateral line neuromast hair cell differentiation	GO:0048923	8	0.046
negative regulation of neuron projection regeneration	GO:0070571	4	0.046
photoreceptor cell development	GO:0042461	40	0.046
epiboly	GO:0090504	41	0.046
establishment of localization	GO:0051234	244	0.046
regulation of protein transport	GO:0051223	3	0.046
spinal cord anterior posterior patterning	GO:0021512	1	0.045
neural tube formation	GO:0001841	16	0.045
otic vesicle formation	GO:0030916	27	0.044
embryonic heart tube development	GO:0035050	133	0.044
protein targeting to nucleus	GO:0044744	3	0.043
gtp catabolic process	GO:0006184	2	0.043
single organism nuclear import	GO:1902593	3	0.043
embryonic pectoral fin morphogenesis	GO:0035118	24	0.042
regulation of neurogenesis	GO:0050767	87	0.042
neuron projection morphogenesis	GO:0048812	161	0.042	Mouse
epithelial cell differentiation	GO:0030855	116	0.042	Zebrafish
cell migration in hindbrain	GO:0021535	7	0.042
negative regulation of canonical wnt signaling pathway	GO:0090090	21	0.041
pancreatic d cell development	GO:0003324	1	0.041
regulation of wnt signaling pathway involved in digestive tract morphogenesis	GO:2000056	2	0.041
nuclear transport	GO:0051169	4	0.041
nephron morphogenesis	GO:0072028	2	0.040
negative regulation of reproductive process	GO:2000242	3	0.040
regulation of multicellular organismal development	GO:2000026	223	0.040
embryonic camera type eye morphogenesis	GO:0048596	19	0.040
morphogenesis of an epithelial sheet	GO:0002011	49	0.039
neuron fate determination	GO:0048664	2	0.039
establishment of protein localization to organelle	GO:0072594	4	0.039
positive regulation of nervous system development	GO:0051962	25	0.039
negative regulation of mesodermal cell fate specification	GO:0042662	3	0.038
aorta development	GO:0035904	4	0.038
cellular response to chemical stimulus	GO:0070887	157	0.038
neural plate regionalization	GO:0060897	10	0.038
spinal cord oligodendrocyte cell fate specification	GO:0021530	2	0.038
mesodermal cell differentiation	GO:0048333	21	0.038
mesodermal cell fate commitment	GO:0001710	14	0.037
female sex differentiation	GO:0046660	4	0.037
cellular protein metabolic process	GO:0044267	129	0.037
nucleoside phosphate metabolic process	GO:0006753	28	0.037
pronephric glomerulus morphogenesis	GO:0035775	6	0.037
retinal cell programmed cell death	GO:0046666	2	0.037
kidney development	GO:0001822	92	0.037
anterior commissure morphogenesis	GO:0021960	3	0.037
compound eye development	GO:0048749	2	0.037
wnt signaling pathway	GO:0016055	80	0.036
small molecule metabolic process	GO:0044281	77	0.036
negative regulation of transcription from rna polymerase ii promoter	GO:0000122	16	0.036
positive regulation of transport	GO:0051050	2	0.036
response to wounding	GO:0009611	116	0.036
neural precursor cell proliferation	GO:0061351	20	0.036
axis specification	GO:0009798	43	0.035
fin development	GO:0033333	77	0.035
negative regulation of signaling	GO:0023057	96	0.035
negative regulation of anterior neural cell fate commitment of the neural plate	GO:0022001	1	0.034
cardiac muscle tissue development	GO:0048738	48	0.034
negative regulation of macromolecule biosynthetic process	GO:0010558	48	0.034
regulation of cell fate commitment	GO:0010453	22	0.034
embryonic skeletal system morphogenesis	GO:0048704	93	0.034
cellular process involved in reproduction in multicellular organism	GO:0022412	28	0.033
mesoderm development	GO:0007498	88	0.033
striated muscle cell differentiation	GO:0051146	129	0.033
negative regulation of nervous system development	GO:0051961	22	0.033
positive regulation of multicellular organismal process	GO:0051240	52	0.033
negative regulation of biosynthetic process	GO:0009890	55	0.033
radial glial cell differentiation	GO:0060019	2	0.032
gliogenesis	GO:0042063	45	0.032
protein metabolic process	GO:0019538	183	0.032
adenohypophysis development	GO:0021984	15	0.032
segmentation	GO:0035282	97	0.032
neuroblast fate determination	GO:0007400	1	0.032
canonical wnt signaling pathway	GO:0060070	48	0.032
regulation of protein localization to nucleus	GO:1900180	2	0.031
thalamus development	GO:0021794	6	0.031
death	GO:0016265	121	0.031
forebrain regionalization	GO:0021871	4	0.031
gabaergic neuron differentiation	GO:0097154	2	0.031
negative regulation of developmental process	GO:0051093	65	0.031
semicircular canal development	GO:0060872	24	0.031
embryo development ending in birth or egg hatching	GO:0009792	271	0.031
negative regulation of anterior neural cell fate commitment of the neural plate by wnt signaling pathway	GO:0022002	1	0.030
non canonical wnt signaling pathway involved in heart development	GO:0061341	2	0.030
gastrulation with mouth forming second	GO:0001702	44	0.030
mediolateral intercalation	GO:0060031	3	0.030
negative regulation of neurogenesis	GO:0050768	20	0.030
cardiac muscle cell differentiation	GO:0055007	30	0.030
ventral spinal cord interneuron specification	GO:0021521	3	0.029
muscle cell development	GO:0055001	115	0.029
phosphorylation	GO:0016310	69	0.029
organophosphate metabolic process	GO:0019637	37	0.029
single organism intracellular transport	GO:1902582	25	0.029
cell proliferation in forebrain	GO:0021846	3	0.029
cell proliferation	GO:0008283	80	0.029
regulation of protein import into nucleus	GO:0042306	2	0.028
single organism transport	GO:0044765	206	0.028
chemosensory behavior	GO:0007635	1	0.028
formation of anatomical boundary	GO:0048859	14	0.028
positive regulation of notch signaling pathway	GO:0045747	3	0.028
posterior lateral line development	GO:0048916	38	0.028
protein modification process	GO:0036211	100	0.028
muscle cell differentiation	GO:0042692	139	0.027
amine metabolic process	GO:0009308	2	0.027
cellular component assembly involved in morphogenesis	GO:0010927	107	0.027
wound healing	GO:0042060	90	0.027
regulation of stem cell differentiation	GO:2000736	4	0.027
negative regulation of collateral sprouting of intact axon in response to injury	GO:0048685	2	0.027
positive regulation of developmental process	GO:0051094	50	0.027
body morphogenesis	GO:0010171	16	0.027
bmp signaling pathway	GO:0030509	52	0.027
posterior lateral line neuromast development	GO:0048919	20	0.027
peripheral nervous system neuron axonogenesis	GO:0048936	13	0.026
cell morphogenesis	GO:0000902	289	0.026	Mouse
forebrain neuron differentiation	GO:0021879	14	0.026
epithelial cell development	GO:0002064	42	0.026
regulation of oligodendrocyte differentiation	GO:0048713	1	0.026
neural crest cell development	GO:0014032	62	0.026
embryonic pattern specification	GO:0009880	44	0.026
central nervous system myelin formation	GO:0032289	1	0.025
negative regulation of catabolic process	GO:0009895	3	0.025
liver development	GO:0001889	96	0.025
pronephric glomerulus development	GO:0039021	13	0.025
neural keel formation	GO:0014025	1	0.025
developmental growth	GO:0048589	166	0.025
apoptotic process	GO:0006915	116	0.025
heart looping	GO:0001947	94	0.025
neuroblast fate commitment	GO:0014017	1	0.025
neuron neuron synaptic transmission	GO:0007270	1	0.025
neuron projection guidance	GO:0097485	86	0.025	Mouse
semicircular canal morphogenesis	GO:0048752	18	0.024
phagocytosis	GO:0006909	3	0.024
protein stabilization	GO:0050821	2	0.024
positive regulation of cell differentiation	GO:0045597	30	0.024
oligodendrocyte cell fate commitment	GO:0021779	5	0.024
regulation of protein modification process	GO:0031399	29	0.024
angioblast cell migration involved in selective angioblast sprouting	GO:0035475	4	0.024
tissue regeneration	GO:0042246	74	0.024
skeletal system morphogenesis	GO:0048705	102	0.024
regulation of cytokine production	GO:0001817	3	0.024
neuron projection development	GO:0031175	180	0.024	Mouse
striated muscle tissue development	GO:0014706	110	0.023
aorta morphogenesis	GO:0035909	3	0.023
regulation of cell migration	GO:0030334	40	0.023
g1 s transition of mitotic cell cycle	GO:0000082	1	0.023
spinal cord dorsal ventral patterning	GO:0021513	5	0.023
optomotor response	GO:0071632	1	0.023
negative regulation of cell differentiation	GO:0045596	46	0.023
regulation of reproductive process	GO:2000241	4	0.023
negative regulation of collateral sprouting	GO:0048671	2	0.023
peripheral nervous system neuron differentiation	GO:0048934	28	0.023
bone morphogenesis	GO:0060349	11	0.023
cell morphogenesis involved in neuron differentiation	GO:0048667	163	0.022	Mouse
cartilage development	GO:0051216	96	0.022
midbrain hindbrain boundary morphogenesis	GO:0021555	5	0.022
immune effector process	GO:0002252	23	0.022
regulation of collateral sprouting of intact axon in response to injury	GO:0048683	2	0.022
cytoskeleton organization	GO:0007010	96	0.022
gtp metabolic process	GO:0046039	4	0.022
wnt signaling pathway involved in digestive tract morphogenesis	GO:0044333	4	0.022
regulation of anatomical structure morphogenesis	GO:0022603	130	0.022
regulation of mapk cascade	GO:0043408	14	0.022
positive regulation of peptidyl tyrosine phosphorylation	GO:0050731	1	0.021
embryonic viscerocranium morphogenesis	GO:0048703	52	0.021
cellular response to organic substance	GO:0071310	105	0.021
neural crest cell differentiation	GO:0014033	72	0.021
cell surface receptor signaling pathway	GO:0007166	325	0.021
regulation of cell motility	GO:2000145	46	0.021
oogenesis	GO:0048477	14	0.021
renal system development	GO:0072001	94	0.021
multi organism process	GO:0051704	134	0.021
spinal cord motor neuron cell fate specification	GO:0021520	8	0.021	Zebrafish
positive regulation of signal transduction	GO:0009967	56	0.020
single organism metabolic process	GO:0044710	217	0.020
inner ear receptor cell development	GO:0060119	20	0.020
cell fate specification involved in pattern specification	GO:0060573	3	0.020
negative regulation of protein phosphorylation	GO:0001933	4	0.020
apoptotic process involved in development	GO:1902742	2	0.020
positive regulation of gastrulation	GO:2000543	2	0.020
regulation of intracellular protein transport	GO:0033157	3	0.020
muscle structure development	GO:0061061	196	0.020
positive regulation of signaling	GO:0023056	56	0.020
protein import	GO:0017038	3	0.020
negative regulation of nodal signaling pathway	GO:1900108	4	0.020
fin regeneration	GO:0031101	51	0.020
positive regulation of secretion	GO:0051047	1	0.020
vasculogenesis	GO:0001570	41	0.019
epithelial to mesenchymal transition	GO:0001837	21	0.019
carbohydrate metabolic process	GO:0005975	12	0.019

gbx1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

	Disease	DO term ID	Size	Probability	Func Analog Org
	disease of anatomical entity	DOID:7	0	0.075
	nervous system disease	DOID:863	0	0.075

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