Danio rerio

16 known processes

cldn15lb

claudin 15-like b

(Aliases: cldn10l1b,zgc:92349)

cldn15lb biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
larval developmentGO:000216420.233
signal transductionGO:00071654550.151
negative regulation of biological processGO:00485193040.107
agingGO:000756820.103
regulation of response to stimulusGO:00485832690.102
nitrogen compound metabolic processGO:00068073190.100
regulation of cell communicationGO:00106462320.100
nucleic acid templated transcriptionGO:00976591810.094
regulation of multicellular organism growthGO:004001440.093
intrahepatic bile duct developmentGO:0035622110.093
regulation of nitrogen compound metabolic processGO:00511712510.090
single organism localizationGO:19025782250.089
cell morphogenesisGO:00009022890.087
digestive tract developmentGO:00485652650.080
regulation of transcription dna templatedGO:00063552130.078
golgi vesicle transportGO:004819330.076
cellular nitrogen compound biosynthetic processGO:00442712180.075
cellular macromolecule biosynthetic processGO:00346452240.075
phagocytosisGO:000690930.074
response to external stimulusGO:00096052640.072
cellular macromolecule metabolic processGO:00442603910.071
regulation of metabolic processGO:00192223590.070
establishment of localizationGO:00512342440.070
rna metabolic processGO:00160702190.070
positive regulation of transportGO:005105020.069
organic cyclic compound metabolic processGO:19013603010.067
cell projection morphogenesisGO:00488582440.067
regulation of signalingGO:00230512350.067
cellular ketone metabolic processGO:0042180110.066
single organism metabolic processGO:00447102170.065
nucleobase containing compound biosynthetic processGO:00346542050.065
regulation of cell differentiationGO:00455951420.064
response to organic substanceGO:00100331530.062
developmental growthGO:00485891660.062
immune system processGO:00023762410.060
regulation of synaptic plasticityGO:004816710.059
autophagyGO:000691440.059
regulation of cellular carbohydrate metabolic processGO:001067540.059
gene expressionGO:00104672520.058
regulation of multicellular organismal developmentGO:20000262230.058
regulation of rna metabolic processGO:00512522240.057
regulation of cytokine productionGO:000181730.057
cellular nitrogen compound metabolic processGO:00346412900.057
regulation of cellular amine metabolic processGO:003323800.057
regulation of multicellular organismal processGO:00512392770.057
regulation of cellular macromolecule biosynthetic processGO:20001122220.056
response to chemicalGO:00422213200.056
transportGO:00068102200.055
monovalent inorganic cation transportGO:0015672420.054
purine nucleoside monophosphate catabolic processGO:000912840.054
organonitrogen compound metabolic processGO:1901564740.053
regulation of dendrite developmentGO:005077330.053
regulation of programmed cell deathGO:00430671010.052
regulation of rna biosynthetic processGO:20011412130.052
negative regulation of sequence specific dna binding transcription factor activityGO:004343320.051
regulation of metal ion transportGO:001095940.050
transmembrane transportGO:00550851200.050
liver developmentGO:0001889960.049
cellular protein catabolic processGO:004425740.049
regulation of nucleobase containing compound metabolic processGO:00192192500.049
cellular component assembly involved in morphogenesisGO:00109271070.049
positive regulation of cellular component biogenesisGO:004408930.048
organelle assemblyGO:00709251100.048
proteasomal protein catabolic processGO:001049820.048
positive regulation of catabolic processGO:000989640.048
nucleobase containing compound metabolic processGO:00061392740.047
cellular aromatic compound metabolic processGO:00067252950.045
protein localization to plasma membraneGO:007265910.045
cation transmembrane transportGO:0098655650.044
negative regulation of kinase activityGO:003367340.044
regulation of signal transductionGO:00099662250.044
regulation of cellular amino acid metabolic processGO:000652100.044
single organism transportGO:00447652060.044
mesenchyme developmentGO:00604851270.044
cellular carbohydrate metabolic processGO:004426240.044
protein heterooligomerizationGO:005129110.043
ribonucleoside monophosphate catabolic processGO:000915840.043
positive regulation of cellular catabolic processGO:003133130.043
regulation of macromolecule biosynthetic processGO:00105562250.042
ubiquitin dependent protein catabolic processGO:000651130.042
negative regulation of rna metabolic processGO:0051253480.042
embryonic organ morphogenesisGO:00485622740.042
atp catabolic processGO:000620040.042
zymogen activationGO:003163830.042
cell substrate adhesionGO:003158940.041
cell part morphogenesisGO:00329902460.041
nucleic acid metabolic processGO:00903042440.041
regulation of carbohydrate metabolic processGO:000610940.041
amino acid transportGO:000686520.040
organic cyclic compound biosynthetic processGO:19013622230.040
negative regulation of signalingGO:0023057960.039
locomotionGO:00400113130.039
regulation of biological qualityGO:00650082630.039
negative regulation of cellular processGO:00485232830.039
cell deathGO:00082191210.038
response to biotic stimulusGO:0009607970.038
gastrulationGO:00073692080.038
muscle cell developmentGO:00550011150.038
cell surface receptor signaling pathwayGO:00071663250.038
cellular response to chemical stimulusGO:00708871570.038
carbohydrate biosynthetic processGO:001605110.038
response to uvGO:000941130.037
regulation of protein transportGO:005122330.037
maintenance of locationGO:005123540.037
organic acid metabolic processGO:0006082310.036
glucose homeostasisGO:004259310.036
regulation of cell developmentGO:00602841000.036
cellular response to starvationGO:000926710.036
pancreas developmentGO:0031016840.036
negative regulation of mapk cascadeGO:004340940.035
rna biosynthetic processGO:00327741810.035
positive regulation of cellular amino acid metabolic processGO:004576400.035
regulation of autophagyGO:001050630.035
amine metabolic processGO:000930820.035
striated muscle tissue developmentGO:00147061100.034
regulation of gene expressionGO:00104682650.034
cilium morphogenesisGO:0060271850.034
cellular response to external stimulusGO:007149620.034
stem cell maintenanceGO:001982740.034
heterocycle metabolic processGO:00464832900.034
negative regulation of protein kinase activityGO:000646940.034
positive regulation of cell cycleGO:004578730.034
oxoacid metabolic processGO:0043436310.034
response to stressGO:00069502630.034
membrane hyperpolarizationGO:006008110.034
cellular amine metabolic processGO:004410620.033
regulation of cellular metabolic processGO:00313233200.033
cellular amino acid metabolic processGO:000652070.033
multicellular organism growthGO:003526440.033
response to other organismGO:0051707970.033
cellular response to nutrient levelsGO:003166920.033
negative regulation of protein phosphorylationGO:000193340.033
eye developmentGO:00016542770.033
regulation of stem cell differentiationGO:200073640.032
positive regulation of cellular processGO:00485222010.032
programmed cell deathGO:00125011190.032
regulation of cell deathGO:00109411030.032
meiotic nuclear divisionGO:000712640.032
protein localization to nucleusGO:003450430.032
cellular component assemblyGO:00226071700.031
regulation of macromolecule metabolic processGO:00602553170.031
cellular biosynthetic processGO:00442492860.031
transcription from rna polymerase ii promoterGO:0006366800.031
intracellular signal transductionGO:0035556850.031
purine ribonucleoside monophosphate catabolic processGO:000916940.031
ion transportGO:00068111140.031
negative regulation of cell communicationGO:0010648960.031
regulation of biosynthetic processGO:00098892500.031
cellular component movementGO:00069283350.031
apoptotic processGO:00069151160.030
nucleoside monophosphate catabolic processGO:000912540.030
proteasome mediated ubiquitin dependent protein catabolic processGO:004316120.030
anterior posterior pattern specificationGO:00099521520.030
negative regulation of biosynthetic processGO:0009890550.030
hematopoietic or lymphoid organ developmentGO:00485341910.030
regulation of synapse organizationGO:005080730.030
negative regulation of metabolic processGO:0009892860.030
digestive system developmentGO:00551232890.030
proteolysis involved in cellular protein catabolic processGO:005160330.029
mechanosensory behaviorGO:000763820.029
i kappab kinase nf kappab signalingGO:000724940.029
tissue remodelingGO:004877140.029
muscle tissue developmentGO:00605371100.029
sleepGO:003043110.029
regulation of apoptotic processGO:0042981980.029
hepaticobiliary system developmentGO:0061008980.028
establishment of protein localization to plasma membraneGO:009000210.028
modification dependent protein catabolic processGO:001994130.028
protein secretionGO:000930610.028
embryonic organ developmentGO:00485683810.028
regulation of developmental processGO:00507932470.028
regulation of dendrite morphogenesisGO:004881430.028
protein importGO:001703830.028
thermosensory behaviorGO:004004010.028
regulation of protein localization to nucleusGO:190018020.028
regulation of i kappab kinase nf kappab signalingGO:004312240.028
regulation of peptidyl tyrosine phosphorylationGO:005073010.027
regulation of cellular ketone metabolic processGO:001056570.027
negative regulation of nucleic acid templated transcriptionGO:1903507450.027
inorganic cation transmembrane transportGO:0098662500.027
enzyme linked receptor protein signaling pathwayGO:00071671060.027
developmental programmed cell deathGO:001062340.027
response to carbohydrateGO:000974330.026
hormone transportGO:000991420.026
biosynthetic processGO:00090582940.026
regulation of anatomical structure morphogenesisGO:00226031300.026
axon developmentGO:00615641660.026
response to external biotic stimulusGO:0043207970.026
deathGO:00162651210.026
regulation of bindingGO:005109830.026
transcription dna templatedGO:00063511810.026
regulation of extrinsic apoptotic signaling pathwayGO:200123630.026
organic substance transportGO:0071702580.026
skeletal muscle tissue developmentGO:0007519670.026
energy reserve metabolic processGO:000611220.026
synaptic growth at neuromuscular junctionGO:005112420.026
protein import into nucleusGO:000660630.025
blood circulationGO:0008015870.025
regulation of circadian rhythmGO:004275240.025
cellular response to organic cyclic compoundGO:0071407380.025
sensory perception of chemical stimulusGO:000760630.025
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathwayGO:0090101220.025
microtubule based movementGO:0007018330.025
small molecule metabolic processGO:0044281770.025
macromolecule biosynthetic processGO:00090592270.025
transmembrane receptor protein serine threonine kinase signaling pathwayGO:0007178680.025
positive regulation of cytokine productionGO:000181920.025
cognitionGO:005089010.025
multi organism cellular processGO:004476420.024
neuron developmentGO:00486662620.024
regulation of transmembrane receptor protein serine threonine kinase signaling pathwayGO:0090092500.024
system processGO:00030081850.024
cilium organizationGO:0044782710.024
negative regulation of macromolecule metabolic processGO:0010605760.024
regulation of inflammatory responseGO:005072720.024
myotube cell developmentGO:0014904350.024
positive regulation of synaptic growth at neuromuscular junctionGO:004588710.024
compound eye developmentGO:004874920.024
regulation of myotube differentiationGO:001083020.024
regulation of cell morphogenesis involved in differentiationGO:0010769380.024
growthGO:00400071740.024
negative regulation of nucleobase containing compound metabolic processGO:0045934590.024
hemopoiesisGO:00300971830.024
negative regulation of cellular metabolic processGO:0031324770.024
regulation of mrna processingGO:005068430.023
carbohydrate homeostasisGO:003350010.023
connective tissue developmentGO:0061448990.023
nuclear transportGO:005116940.023
regulation of organ growthGO:004662030.023
cellular response to organic substanceGO:00713101050.023
carboxylic acid metabolic processGO:0019752220.023
morphogenesis of an epitheliumGO:00020093330.023
positive regulation of gtpase activityGO:004354710.023
regulation of protein targetingGO:190353320.023
cell projection organizationGO:00300302840.023
negative regulation of signal transductionGO:0009968940.022
negative regulation of response to stimulusGO:00485851040.022
tube morphogenesisGO:00352393490.022
establishment of protein localization to organelleGO:007259440.022
meiotic cell cycle processGO:190304630.022
nucleocytoplasmic transportGO:000691340.022
regulation of response to biotic stimulusGO:000283120.022
regulation of cysteine type endopeptidase activityGO:2000116210.022
gtp catabolic processGO:000618420.022
vasculature developmentGO:00019442780.022
organic substance biosynthetic processGO:19015762890.021
positive regulation of cellular amine metabolic processGO:003324000.021
muscle organ developmentGO:00075171010.021
lipid storageGO:001991510.021
regulation of neurogenesisGO:0050767870.021
heterocycle biosynthetic processGO:00181302150.021
adult behaviorGO:003053420.021
neuroblast differentiationGO:001401610.021
regulation of blood pressureGO:000821710.021
actin filament based movementGO:003004810.021
positive regulation of biological processGO:00485182530.021
cellular response to extracellular stimulusGO:003166820.021
modification dependent macromolecule catabolic processGO:004363230.021
guanosine containing compound catabolic processGO:190106920.021
positive regulation of cellular metabolic processGO:0031325940.021
erk1 and erk2 cascadeGO:007037140.020
positive regulation of apoptotic signaling pathwayGO:200123510.020
macromolecule modificationGO:00434121110.020
regulation of blood vessel sizeGO:005088020.020
hormone secretionGO:004687920.020
regulation of tube sizeGO:003515020.020
ion transmembrane transportGO:0034220910.020
regulation of transcription from rna polymerase ii promoterGO:00063571140.020
neuron projection morphogenesisGO:00488121610.020
skeletal muscle organ developmentGO:0060538780.020
response to glucoseGO:000974930.020
cellular component biogenesisGO:00440851780.020
positive regulation of peptidyl tyrosine phosphorylationGO:005073110.020
myeloid cell differentiationGO:0030099860.020
negative regulation of defense responseGO:003134820.020
cellular response to endogenous stimulusGO:0071495680.020
regulation of localizationGO:00328791040.020
cellular response to hormone stimulusGO:0032870390.020
regulation of cell morphogenesisGO:0022604420.020
renal system developmentGO:0072001940.020
negative regulation of cytokine productionGO:000181810.019
muscle structure developmentGO:00610611960.019
cellular localizationGO:0051641970.019
sensory organ developmentGO:00074233930.019
regulation of ion transmembrane transporter activityGO:003241220.019
cellular component morphogenesisGO:00329893360.019
regulation of cytoplasmic transportGO:190364940.019
macromolecule localizationGO:0033036540.019
developmental growth involved in morphogenesisGO:0060560860.019
cell migrationGO:00164772370.019
negative regulation of cysteine type endopeptidase activity involved in apoptotic processGO:004315470.019
extrinsic apoptotic signaling pathwayGO:009719130.019
regulation of synapse assemblyGO:005196330.019
regulation of synaptic growth at neuromuscular junctionGO:000858210.019
regulation of protein import into nucleusGO:004230620.019
macroautophagyGO:001623610.019
regulation of glucose importGO:004632410.019
sensory organ morphogenesisGO:00905962000.019
gland developmentGO:00487321430.019
mitotic dna damage checkpointGO:004477340.019
regulation of phosphate metabolic processGO:0019220430.019
stem cell fate commitmentGO:004886510.019
aromatic compound biosynthetic processGO:00194382170.019
stem cell proliferationGO:007208940.018
neurological system processGO:0050877620.018
regulation of nucleotide catabolic processGO:003081120.018
type b pancreatic cell developmentGO:000332340.018
sulfur compound metabolic processGO:0006790130.018
membrane invaginationGO:001032410.018
negative regulation of cell deathGO:0060548600.018
skeletal system developmentGO:00015011810.018
morphogenesis of an epithelial sheetGO:0002011490.018
metal ion transportGO:0030001580.018
protein targeting to nucleusGO:004474430.018
negative regulation of gene expressionGO:0010629650.018
negative regulation of catabolic processGO:000989530.018
regulation of nucleic acid templated transcriptionGO:19035062130.018
sodium ion transmembrane transportGO:0035725210.018
regulation of transmembrane transporter activityGO:002289820.017
regulation of molecular functionGO:0065009700.017
negative regulation of apoptotic processGO:0043066550.017
phagocytosis engulfmentGO:000691110.017
positive regulation of purine nucleotide catabolic processGO:003312310.017
negative regulation of transcription dna templatedGO:0045892450.017
guanosine containing compound metabolic processGO:190106840.017
urogenital system developmentGO:0001655970.017
axis specificationGO:0009798430.017
peptide transportGO:001583310.017
bone remodelingGO:004684920.017
cellular response to oxygen levelsGO:007145310.017
specification of symmetryGO:00097992040.017
chordate embryonic developmentGO:00430092710.017
circulatory system processGO:0003013870.017
dicarboxylic acid transportGO:000683510.017
cellular response to radiationGO:007147840.017
response to temperature stimulusGO:0009266150.017
translational initiationGO:000641330.017
regulation of glucose transportGO:001082710.017
negative regulation of nitrogen compound metabolic processGO:0051172590.017
cardiac atrium developmentGO:000323040.017
polarized epithelial cell differentiationGO:003085940.017
post golgi vesicle mediated transportGO:000689210.017
peptide metabolic processGO:000651810.017
digestive tract morphogenesisGO:00485462310.017
cellular lipid catabolic processGO:004424230.017
neurotransmitter transportGO:000683620.017
positive regulation of nucleoside metabolic processGO:004597910.017
endocrine processGO:005088620.017
regulation of carbohydrate biosynthetic processGO:004325510.016
cellular response to hypoxiaGO:007145610.016
muscle fiber developmentGO:0048747520.016
regulation of tissue remodelingGO:003410320.016
negative regulation of cellular biosynthetic processGO:0031327550.016
regulation of protein modification by small protein conjugation or removalGO:190332030.016
g1 s transition of mitotic cell cycleGO:000008210.016
generation of neuronsGO:00486993850.016
positive regulation of secretionGO:005104710.016
response to alkaloidGO:004327920.016
positive regulation of nitrogen compound metabolic processGO:0051173690.016
regulation of peptidase activityGO:0052547230.016
regionalizationGO:00030022740.016
negative regulation of programmed cell deathGO:0043069580.016
nuclear importGO:005117030.016
single organism organelle organizationGO:19025891990.016
regulation of neural precursor cell proliferationGO:200017730.016
regulation of intracellular protein transportGO:003315730.016
cation transportGO:0006812810.016
multi organism processGO:00517041340.016
stem cell differentiationGO:00488631170.016
oocyte anterior posterior axis specificationGO:000731440.016
regulation of protein catabolic processGO:004217610.015
regulation of hormone secretionGO:004688320.015
smooth muscle contractionGO:000693920.015
spermatid differentiationGO:004851520.015
peptidyl serine phosphorylationGO:001810510.015
meiotic chromosome segregationGO:004513230.015
astrocyte differentiationGO:004870810.015
regulation of membrane potentialGO:0042391230.015
striated muscle cell developmentGO:00550021080.015
positive regulation of nucleotide catabolic processGO:003081310.015
symbiosis encompassing mutualism through parasitismGO:004440340.015
cilium assemblyGO:0042384580.015
sensory perception of touchGO:005097520.015
positive regulation of secretion by cellGO:190353210.015
blood vessel morphogenesisGO:00485142160.015
positive regulation of synapse assemblyGO:005196510.015
cellular response to steroid hormone stimulusGO:0071383310.015
protein localizationGO:0008104400.015
regulation of cellular biosynthetic processGO:00313262450.015
negative regulation of cellular macromolecule biosynthetic processGO:2000113480.015
actin mediated cell contractionGO:007025210.015
positive regulation of protein complex assemblyGO:003133420.015
fatty acid catabolic processGO:000906210.015
regulation of purine nucleotide catabolic processGO:003312120.015
regulation of primary metabolic processGO:00800903110.015
neuron neuron synaptic transmissionGO:000727010.015
response to drugGO:004249330.015
protein metabolic processGO:00195381830.015
response to woundingGO:00096111160.015
regulation of dna replicationGO:000627530.015
regulation of nucleoside metabolic processGO:000911820.015
negative regulation of secretion by cellGO:190353120.014
skeletal system morphogenesisGO:00487051020.014
amide biosynthetic processGO:004360410.014
regulation of growth rateGO:004000910.014
regenerationGO:0031099910.014
organelle organizationGO:00069962270.014
synaptic vesicle localizationGO:009747910.014
organism emergence from protective structureGO:007168440.014
negative regulation of transcription from rna polymerase ii promoterGO:0000122160.014
hormone biosynthetic processGO:004244630.014
specification of axis polarityGO:006500140.014
positive regulation of multicellular organismal processGO:0051240520.014
inner ear developmentGO:00488391260.014
gtp metabolic processGO:004603940.014
eye morphogenesisGO:00485921440.014
regulation of cysteine type endopeptidase activity involved in apoptotic processGO:0043281200.014
neuromast developmentGO:0048884460.014
single organism nuclear importGO:190259330.014
positive regulation of glucose importGO:004632610.014
locomotor rhythmGO:004547530.014
neuroblast proliferationGO:000740520.014
regulation of erk1 and erk2 cascadeGO:007037240.014
negative regulation of stem cell differentiationGO:200073720.014
cardiac muscle cell developmentGO:0055013200.014
regulation of anatomical structure sizeGO:0090066330.014
negative regulation of rna biosynthetic processGO:1902679450.014
synaptic transmission cholinergicGO:000727140.014
cell cycle arrestGO:000705010.014
synaptic vesicle transportGO:004848910.014
positive regulation of i kappab kinase nf kappab signalingGO:004312330.014
sensory perception of smellGO:000760820.014
taxisGO:00423301090.014
establishment of localization in cellGO:0051649770.014
kupffer s vesicle developmentGO:0070121500.014
segmentationGO:0035282970.014
striated muscle cell differentiationGO:00511461290.014
protein homooligomerizationGO:005126030.014
response to hydrogen peroxideGO:004254230.013
positive regulation of cytoskeleton organizationGO:005149530.013
response to abiotic stimulusGO:00096281220.013
negative regulation of extrinsic apoptotic signaling pathwayGO:200123720.013
positive regulation of ras protein signal transductionGO:004657910.013
regulation of nucleocytoplasmic transportGO:004682220.013
negative regulation of cell differentiationGO:0045596460.013
embryo development ending in birth or egg hatchingGO:00097922710.013
cell motilityGO:00488702440.013
regulation of neuronal synaptic plasticityGO:004816810.013
mitotic cell cycle embryonicGO:004544820.013
regulation of endocrine processGO:004406020.013
regulation of cell projection organizationGO:0031344440.013
regulation of transporter activityGO:003240920.013
cell cycle g1 s phase transitionGO:004484310.013
cell morphogenesis involved in differentiationGO:00009041950.013
heart developmentGO:00075073130.013
hatchingGO:003518840.013
regulation of establishment of protein localizationGO:007020140.013
regulation of jak stat cascadeGO:004642530.013
response to nicotineGO:003509420.013
immune system developmentGO:00025201910.013
cellular response to decreased oxygen levelsGO:003629410.013
cytoplasm organizationGO:000702840.013
mitotic dna integrity checkpointGO:004477440.013
cellular component disassemblyGO:002241110.013
regulation of postsynaptic membrane potentialGO:006007810.013
mesenchymal cell developmentGO:0014031780.013
mitochondrion organizationGO:000700540.013
inorganic ion transmembrane transportGO:0098660570.013
single organism behaviorGO:0044708240.013
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domainsGO:000246040.013
production of molecular mediator of immune responseGO:000244020.013
interspecies interaction between organismsGO:004441940.013
establishment of synaptic vesicle localizationGO:009748010.013
circadian sleep wake cycleGO:004274520.013
bmp signaling pathwayGO:0030509520.013
stem cell developmentGO:0048864820.013
neuroblast fate commitmentGO:001401710.013
pole plasm assemblyGO:000731540.013
mrna 3 end processingGO:003112420.013
regulation of cell shapeGO:000836010.013
positive regulation of muscle organ developmentGO:004863610.013
cartilage developmentGO:0051216960.013
lipid catabolic processGO:001604240.013
embryonic hemopoiesisGO:0035162530.012
ribosome assemblyGO:004225510.012
regulation of systemic arterial blood pressureGO:000307310.012
regulation of cellular component organizationGO:0051128860.012

cldn15lb disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.040
disease of metabolismDOID:001466700.032
nervous system diseaseDOID:86300.018
inherited metabolic disorderDOID:65500.018
organ system cancerDOID:005068600.016
cancerDOID:16200.016
disease of cellular proliferationDOID:1456600.016
cardiovascular system diseaseDOID:128700.013