IMP: Integrative Multi-species Prediction

Danio rerio

24 known processes

gsc

goosecoid

(Aliases: xx:tdsubc_2h11,zgc:101595,ik:tdsubc_1c10,ik:tdsubc_2h11,xx:tdsubc_1c10,xx:tdsubc_2g4,MGC101595,ik:tdsubc_2g4,ZGSC)

Ensembl: ENSDARG00000059073
Entrez: 30212
ZFIN: ZDB-GENE-980528-2060
UniProtKB: B2GRD3
UniProtKB: P53544

Process Predictions
Disease Predictions

gsc biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
regulation of cellular macromolecule biosynthetic process	GO:2000112	222	0.990	Zebrafish Mouse Fly
tube morphogenesis	GO:0035239	349	0.984	Zebrafish
regulation of cell communication	GO:0010646	232	0.971	Zebrafish Mouse
signal transduction	GO:0007165	455	0.965	Zebrafish Mouse
regulation of multicellular organismal process	GO:0051239	277	0.962	Zebrafish
cellular biosynthetic process	GO:0044249	286	0.954	Mouse Fly
digestive tract morphogenesis	GO:0048546	231	0.933	Zebrafish
appendage morphogenesis	GO:0035107	56	0.920
mesenchymal cell development	GO:0014031	78	0.920	Human
digestive system development	GO:0055123	289	0.906	Zebrafish
mesenchymal cell differentiation	GO:0048762	87	0.901	Human
transcription dna templated	GO:0006351	181	0.896	Mouse Fly
limb bud formation	GO:0060174	2	0.893
female gonad development	GO:0008585	4	0.883
sensory organ development	GO:0007423	393	0.883	Mouse
appendage development	GO:0048736	80	0.881
mesenchyme development	GO:0060485	127	0.862	Human Zebrafish
heart morphogenesis	GO:0003007	156	0.860	Zebrafish
cell surface receptor signaling pathway	GO:0007166	325	0.854	Zebrafish Mouse
cellular aromatic compound metabolic process	GO:0006725	295	0.850	Mouse Fly
mesoderm development	GO:0007498	88	0.842	Zebrafish
digestive tract development	GO:0048565	265	0.836	Zebrafish
organic cyclic compound metabolic process	GO:1901360	301	0.823	Mouse Fly
response to stress	GO:0006950	263	0.803
connective tissue development	GO:0061448	99	0.803
neural crest cell differentiation	GO:0014033	72	0.779	Human
determination of left right asymmetry in nervous system	GO:0035545	4	0.777
regulation of developmental process	GO:0050793	247	0.767	Zebrafish
regulation of transcription from rna polymerase ii promoter	GO:0006357	114	0.765	Zebrafish Mouse Fly
regulation of macromolecule biosynthetic process	GO:0010556	225	0.762	Zebrafish Mouse Fly
regulation of protein catabolic process	GO:0042176	1	0.744
negative regulation of biological process	GO:0048519	304	0.736	Mouse Fly
regulation of signaling	GO:0023051	235	0.726	Zebrafish Mouse
pectoral fin development	GO:0033339	50	0.723
negative regulation of wnt signaling pathway	GO:0030178	30	0.719	Mouse
chordate embryonic development	GO:0043009	271	0.716	Human Mouse
head development	GO:0060322	303	0.695
regulation of response to stimulus	GO:0048583	269	0.686	Zebrafish Mouse
eye morphogenesis	GO:0048592	144	0.681
transcription from rna polymerase ii promoter	GO:0006366	80	0.680	Mouse Fly
central nervous system development	GO:0007417	387	0.677
diencephalon development	GO:0021536	58	0.672
nucleobase containing compound biosynthetic process	GO:0034654	205	0.670	Mouse Fly
negative regulation of transcription from rna polymerase ii promoter	GO:0000122	16	0.649	Mouse Fly
skeletal system development	GO:0001501	181	0.641	Mouse
embryonic appendage morphogenesis	GO:0035113	30	0.638
ameboidal type cell migration	GO:0001667	143	0.633
neural crest cell development	GO:0014032	62	0.613
negative regulation of nodal signaling pathway	GO:1900108	4	0.611
negative regulation of cellular metabolic process	GO:0031324	77	0.602	Mouse Fly
wnt signaling pathway	GO:0016055	80	0.600	Mouse
cellular macromolecule metabolic process	GO:0044260	391	0.592	Mouse Fly
regulation of primary metabolic process	GO:0080090	311	0.582	Zebrafish Mouse Fly
cartilage development	GO:0051216	96	0.570
aromatic compound biosynthetic process	GO:0019438	217	0.557	Mouse Fly
regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090092	50	0.538	Zebrafish
regulation of epithelial cell proliferation	GO:0050678	3	0.527
regulation of programmed cell death	GO:0043067	101	0.527
cell morphogenesis	GO:0000902	289	0.526	Human
embryonic pectoral fin morphogenesis	GO:0035118	24	0.526
regulation of rna biosynthetic process	GO:2001141	213	0.523	Zebrafish Mouse Fly
specification of symmetry	GO:0009799	204	0.513	Zebrafish
death	GO:0016265	121	0.495
development of primary female sexual characteristics	GO:0046545	4	0.493
sensory organ morphogenesis	GO:0090596	200	0.491	Mouse
vasculature development	GO:0001944	278	0.488
forebrain development	GO:0030900	96	0.473	Mouse
negative regulation of gene expression	GO:0010629	65	0.473	Mouse Fly
odontogenesis of dentin containing tooth	GO:0042475	1	0.459
regulation of metabolic process	GO:0019222	359	0.457	Zebrafish Mouse Fly
cartilage condensation	GO:0001502	3	0.457
regulation of cellular metabolic process	GO:0031323	320	0.446	Zebrafish Mouse Fly
epithelial tube morphogenesis	GO:0060562	148	0.445	Zebrafish
endocardial cushion formation	GO:0003272	2	0.440
cell fate specification	GO:0001708	68	0.426	Human
inner ear development	GO:0048839	126	0.420
intermediate mesoderm development	GO:0048389	2	0.410
bmp signaling pathway	GO:0030509	52	0.403	Zebrafish
female sex differentiation	GO:0046660	4	0.399
heterocycle metabolic process	GO:0046483	290	0.397	Mouse Fly
cell morphogenesis involved in differentiation	GO:0000904	195	0.395	Human
positive regulation of cellular process	GO:0048522	201	0.393	Zebrafish
fin morphogenesis	GO:0033334	53	0.391
fin development	GO:0033333	77	0.384
bmp signaling pathway involved in heart development	GO:0061312	15	0.383	Zebrafish
gastrulation	GO:0007369	208	0.379	Zebrafish
astrocyte differentiation	GO:0048708	1	0.378
negative regulation of activin receptor signaling pathway	GO:0032926	5	0.375
regulation of rna metabolic process	GO:0051252	224	0.373	Zebrafish Mouse Fly
regulation of wnt signaling pathway	GO:0030111	53	0.369	Mouse
skeletal system morphogenesis	GO:0048705	102	0.365	Mouse
embryonic limb morphogenesis	GO:0030326	2	0.355
stem cell differentiation	GO:0048863	117	0.352	Human
ear development	GO:0043583	127	0.352	Mouse
embryonic organ morphogenesis	GO:0048562	274	0.350	Zebrafish Mouse
retina development in camera type eye	GO:0060041	146	0.339
cellular component morphogenesis	GO:0032989	336	0.338	Human
pigment cell differentiation	GO:0050931	38	0.335
cellular nitrogen compound metabolic process	GO:0034641	290	0.332	Mouse Fly
nucleobase containing compound metabolic process	GO:0006139	274	0.329	Mouse Fly
eye development	GO:0001654	277	0.329
negative regulation of cellular process	GO:0048523	283	0.319	Mouse Fly
biosynthetic process	GO:0009058	294	0.315	Mouse Fly
mesodermal to mesenchymal transition involved in gastrulation	GO:0060809	1	0.311
dorsal ventral pattern formation	GO:0009953	125	0.310
determination of left right asymmetry in diencephalon	GO:0035462	4	0.306
localization of cell	GO:0051674	244	0.289
endodermal cell fate determination	GO:0007493	2	0.279
organic cyclic compound biosynthetic process	GO:1901362	223	0.275	Mouse Fly
nitrogen compound metabolic process	GO:0006807	319	0.271	Mouse Fly
cellular nitrogen compound biosynthetic process	GO:0044271	218	0.271	Mouse Fly
regionalization	GO:0003002	274	0.269
regulation of multicellular organismal development	GO:2000026	223	0.266	Zebrafish
cell motility	GO:0048870	244	0.262
regulation of gastrulation	GO:0010470	24	0.255
morphogenesis of an epithelium	GO:0002009	333	0.253	Zebrafish
optic placode formation involved in camera type eye formation	GO:0046619	3	0.249
regulation of apoptotic process	GO:0042981	98	0.248
chondrocyte development	GO:0002063	4	0.246
regulation of oligodendrocyte differentiation	GO:0048713	1	0.245
retina morphogenesis in camera type eye	GO:0060042	79	0.239
regulation of macromolecule metabolic process	GO:0060255	317	0.235	Zebrafish Mouse Fly
negative regulation of nucleic acid templated transcription	GO:1903507	45	0.235	Mouse Fly
cell fate commitment	GO:0045165	99	0.235	Human Zebrafish
regulation of glial cell differentiation	GO:0045685	4	0.234
larval development	GO:0002164	2	0.232
fat soluble vitamin metabolic process	GO:0006775	4	0.226
regulation of signal transduction	GO:0009966	225	0.224	Zebrafish Mouse
stem cell maintenance	GO:0019827	4	0.223
regulation of cellular biosynthetic process	GO:0031326	245	0.222	Zebrafish Mouse Fly
organic substance biosynthetic process	GO:1901576	289	0.220	Mouse Fly
pectoral fin morphogenesis	GO:0035138	29	0.212
negative regulation of macromolecule biosynthetic process	GO:0010558	48	0.211	Mouse Fly
regulation of canonical wnt signaling pathway	GO:0060828	34	0.207
tissue regeneration	GO:0042246	74	0.205
stem cell proliferation	GO:0072089	4	0.204
regulation of bmp signaling pathway	GO:0030510	39	0.201	Zebrafish
eye photoreceptor cell differentiation	GO:0001754	45	0.200
inner ear morphogenesis	GO:0042472	63	0.199
cartilage morphogenesis	GO:0060536	13	0.196
positive regulation of striated muscle cell differentiation	GO:0051155	1	0.196
regulation of embryonic development	GO:0045995	47	0.194	Zebrafish
heart jogging	GO:0003146	40	0.191	Zebrafish
camera type eye development	GO:0043010	222	0.191
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	68	0.187	Zebrafish
regulation of nitrogen compound metabolic process	GO:0051171	251	0.185	Zebrafish Mouse Fly
photoreceptor cell differentiation	GO:0046530	55	0.183
limb morphogenesis	GO:0035108	7	0.182
cell projection morphogenesis	GO:0048858	244	0.182
mesenchymal cell proliferation	GO:0010463	1	0.182
oocyte maturation	GO:0001556	4	0.181
negative regulation of transcription dna templated	GO:0045892	45	0.179	Mouse Fly
negative regulation of signal transduction	GO:0009968	94	0.178	Mouse
camera type eye morphogenesis	GO:0048593	108	0.178
negative regulation of protein phosphorylation	GO:0001933	4	0.174
embryonic skeletal system development	GO:0048706	97	0.174	Mouse
cellular hormone metabolic process	GO:0034754	19	0.173
bmp signaling pathway involved in heart jogging	GO:0003303	14	0.172	Zebrafish
mesendoderm development	GO:0048382	10	0.172
muscle tissue development	GO:0060537	110	0.170
proteasome mediated ubiquitin dependent protein catabolic process	GO:0043161	2	0.167
muscle cell differentiation	GO:0042692	139	0.164
negative regulation of cellular biosynthetic process	GO:0031327	55	0.163	Mouse Fly
mesoderm morphogenesis	GO:0048332	51	0.162	Zebrafish
cell aggregation	GO:0098743	3	0.159
determination of bilateral symmetry	GO:0009855	204	0.158	Zebrafish
circulatory system process	GO:0003013	87	0.157
negative regulation of nucleobase containing compound metabolic process	GO:0045934	59	0.156	Mouse Fly
ectodermal placode morphogenesis	GO:0071697	32	0.156
cell death	GO:0008219	121	0.155
cell migration involved in gastrulation	GO:0042074	79	0.154
regulation of nucleobase containing compound metabolic process	GO:0019219	250	0.154	Zebrafish Mouse Fly
response to abiotic stimulus	GO:0009628	122	0.153
embryonic organ development	GO:0048568	381	0.152	Zebrafish Mouse
renal system development	GO:0072001	94	0.151
regulation of stem cell proliferation	GO:0072091	2	0.150
establishment of protein localization to organelle	GO:0072594	4	0.149
apoptotic process	GO:0006915	116	0.149
regulation of cell differentiation	GO:0045595	142	0.148
regulation of eye photoreceptor cell development	GO:0042478	2	0.145
epiboly	GO:0090504	41	0.145
otic vesicle development	GO:0071599	42	0.144
determination of dorsal ventral asymmetry	GO:0048262	34	0.142
striated muscle cell development	GO:0055002	108	0.141
neural crest cell migration	GO:0001755	42	0.141
determination of left right symmetry	GO:0007368	179	0.141	Zebrafish
generation of neurons	GO:0048699	385	0.140
regulation of nucleic acid templated transcription	GO:1903506	213	0.139	Zebrafish Mouse Fly
neuron differentiation	GO:0030182	353	0.138
hatching gland development	GO:0048785	3	0.136
regulation of nodal signaling pathway	GO:1900107	4	0.136
regulation of cell death	GO:0010941	103	0.135
regulation of gene expression	GO:0010468	265	0.135	Zebrafish Mouse Fly
enzyme linked receptor protein signaling pathway	GO:0007167	106	0.133	Zebrafish
ectoderm formation	GO:0001705	2	0.133
kidney development	GO:0001822	92	0.133
kupffer s vesicle development	GO:0070121	50	0.132
endocardial cushion morphogenesis	GO:0003203	3	0.130
regulation of dna damage response signal transduction by p53 class mediator	GO:0043516	4	0.129
otic vesicle formation	GO:0030916	27	0.128
regulation of oxidative stress induced cell death	GO:1903201	2	0.128
sprouting angiogenesis	GO:0002040	53	0.128
positive regulation of cell proliferation	GO:0008284	15	0.125
protein import into nucleus	GO:0006606	3	0.125
embryonic heart tube left right pattern formation	GO:0060971	5	0.124
epithelial tube formation	GO:0072175	19	0.123
negative regulation of rna metabolic process	GO:0051253	48	0.123	Mouse Fly
embryonic foregut morphogenesis	GO:0048617	1	0.121
immune system process	GO:0002376	241	0.119
epithelial to mesenchymal transition	GO:0001837	21	0.117	Human
limb development	GO:0060173	8	0.117
eye field cell fate commitment involved in camera type eye formation	GO:0060898	3	0.117
endodermal cell fate specification	GO:0001714	17	0.116
heart formation	GO:0060914	13	0.115
cell proliferation in hindbrain	GO:0021534	4	0.115
cellular response to retinoic acid	GO:0071300	1	0.115
negative regulation of nitrogen compound metabolic process	GO:0051172	59	0.114	Mouse Fly
positive regulation of oligodendrocyte differentiation	GO:0048714	1	0.113
cellular response to stress	GO:0033554	62	0.113
anterior posterior pattern specification	GO:0009952	152	0.112
macromolecule biosynthetic process	GO:0009059	227	0.112	Mouse Fly
activin receptor signaling pathway	GO:0032924	8	0.111
cell migration	GO:0016477	237	0.109
embryo development ending in birth or egg hatching	GO:0009792	271	0.109	Human Mouse Worm
ovarian follicle development	GO:0001541	2	0.109
positive regulation of muscle cell differentiation	GO:0051149	1	0.108
immune system development	GO:0002520	191	0.107
positive regulation of metabolic process	GO:0009893	108	0.106
blood vessel development	GO:0001568	246	0.106
positive regulation of epithelial cell proliferation	GO:0050679	1	0.105
otic placode formation	GO:0043049	23	0.105
neuron fate specification	GO:0048665	20	0.104
gland development	GO:0048732	143	0.104
positive regulation of stem cell proliferation	GO:2000648	1	0.103
anterior commissure morphogenesis	GO:0021960	3	0.102
notochord development	GO:0030903	54	0.102	Zebrafish
axonogenesis	GO:0007409	152	0.101
auditory receptor cell fate commitment	GO:0009912	4	0.099
cellular aldehyde metabolic process	GO:0006081	4	0.099
periodic partitioning	GO:0007365	1	0.098
endodermal digestive tract morphogenesis	GO:0061031	2	0.098
heart development	GO:0007507	313	0.097	Zebrafish
pituitary gland development	GO:0021983	16	0.096
intestinal epithelial cell differentiation	GO:0060575	3	0.093
epithelial cell proliferation	GO:0050673	17	0.093
regulation of biosynthetic process	GO:0009889	250	0.093	Zebrafish Mouse Fly
response to organic substance	GO:0010033	153	0.092	Zebrafish
regulation of transcription from rna polymerase ii promoter involved in heart development	GO:1901213	15	0.092	Zebrafish
positive regulation of rna metabolic process	GO:0051254	59	0.091
gastrulation with mouth forming second	GO:0001702	44	0.090
response to nutrient	GO:0007584	3	0.090
fin regeneration	GO:0031101	51	0.089
cellular response to radiation	GO:0071478	4	0.088
segment polarity determination	GO:0007367	1	0.088
vasculogenesis	GO:0001570	41	0.088
response to vitamin	GO:0033273	3	0.088
regeneration	GO:0031099	91	0.088
inner ear receptor cell development	GO:0060119	20	0.088
locomotion	GO:0040011	313	0.086
cellular component movement	GO:0006928	335	0.086
angiogenesis	GO:0001525	158	0.085
cell migration involved in mesendoderm migration	GO:0090134	2	0.084
blood vessel morphogenesis	GO:0048514	216	0.083
hepatocyte differentiation	GO:0070365	1	0.082
negative regulation of biosynthetic process	GO:0009890	55	0.082	Mouse Fly
positive regulation of gastrulation	GO:2000543	2	0.082
convergent extension involved in gastrulation	GO:0060027	71	0.080
glomerulus vasculature development	GO:0072012	2	0.080
epithelial cell differentiation	GO:0030855	116	0.079
retinal metabolic process	GO:0042574	3	0.078
response to external stimulus	GO:0009605	264	0.077
nucleic acid metabolic process	GO:0090304	244	0.077	Mouse Fly
cell morphogenesis involved in neuron differentiation	GO:0048667	163	0.077
erythrocyte homeostasis	GO:0034101	55	0.077
regulation of bmp signaling pathway involved in heart jogging	GO:2000223	12	0.077	Zebrafish
neuron projection development	GO:0031175	180	0.076
determination of heart left right asymmetry	GO:0061371	117	0.075	Zebrafish
foregut morphogenesis	GO:0007440	4	0.075
neuronal stem cell maintenance	GO:0097150	2	0.075
nephric duct development	GO:0072176	13	0.075
retinal ganglion cell axon guidance	GO:0031290	35	0.074
cellular response to external stimulus	GO:0071496	2	0.074
artery development	GO:0060840	22	0.074
formation of primary germ layer	GO:0001704	62	0.074	Zebrafish
somitogenesis	GO:0001756	87	0.073
morphogenesis of embryonic epithelium	GO:0016331	30	0.072
embryonic cranial skeleton morphogenesis	GO:0048701	90	0.071
ear morphogenesis	GO:0042471	64	0.071	Mouse
melanosome transport	GO:0032402	19	0.071
otic vesicle morphogenesis	GO:0071600	34	0.070
regulation of cartilage development	GO:0061035	7	0.070
regulation of sterol transport	GO:0032371	3	0.070
embryonic skeletal system morphogenesis	GO:0048704	93	0.070	Mouse
negative regulation of transcription elongation from rna polymerase ii promoter	GO:0034244	1	0.068
hematopoietic or lymphoid organ development	GO:0048534	191	0.066
response to wounding	GO:0009611	116	0.066
dorsal ventral neural tube patterning	GO:0021904	1	0.065	Mouse
negative regulation of leukocyte differentiation	GO:1902106	1	0.064
regulation of transcription from rna polymerase ii promoter involved in determination of left right symmetry	GO:1900094	17	0.064	Zebrafish
cell differentiation in spinal cord	GO:0021515	40	0.063
inner ear receptor cell differentiation	GO:0060113	29	0.063
neuroblast proliferation	GO:0007405	2	0.063
embryonic viscerocranium morphogenesis	GO:0048703	52	0.063
negative regulation of canonical wnt signaling pathway	GO:0090090	21	0.061
pronephros development	GO:0048793	69	0.061
angioblast cell differentiation	GO:0035779	2	0.061
embryonic heart tube development	GO:0035050	133	0.061	Zebrafish
cell proliferation	GO:0008283	80	0.061
ectodermal placode formation	GO:0060788	26	0.060
response to uv	GO:0009411	3	0.060
metencephalon development	GO:0022037	27	0.059
positive regulation of catabolic process	GO:0009896	4	0.059
eye photoreceptor cell development	GO:0042462	30	0.058
negative regulation of response to stimulus	GO:0048585	104	0.057	Mouse
negative regulation of mapk cascade	GO:0043409	4	0.057
positive regulation of glial cell differentiation	GO:0045687	1	0.056
lateral inhibition	GO:0046331	1	0.056
regulation of response to stress	GO:0080134	36	0.055
developmental pigmentation	GO:0048066	48	0.055
cell cell adhesion involved in mesendodermal cell migration	GO:0003370	1	0.055
regulation of cell development	GO:0060284	100	0.055
cranial nerve development	GO:0021545	42	0.055
spinal cord development	GO:0021510	46	0.055
cell surface receptor signaling pathway involved in heart development	GO:0061311	20	0.054	Zebrafish
embryonic retina morphogenesis in camera type eye	GO:0060059	22	0.054
ovulation cycle	GO:0042698	2	0.054
positive regulation of signaling	GO:0023056	56	0.054	Zebrafish
cellular macromolecule biosynthetic process	GO:0034645	224	0.054	Mouse Fly
multi organism process	GO:0051704	134	0.054
cardioblast migration	GO:0003260	7	0.053
photoreceptor cell development	GO:0042461	40	0.053
axis elongation involved in somitogenesis	GO:0090245	2	0.053
lymphocyte differentiation	GO:0030098	9	0.053
spinal cord oligodendrocyte cell differentiation	GO:0021529	5	0.053
endocardial progenitor cell migration to the midline involved in heart field formation	GO:0003262	4	0.053
negative regulation of protein serine threonine kinase activity	GO:0071901	2	0.053
regulation of chondrocyte differentiation	GO:0032330	1	0.052
negative regulation of cell death	GO:0060548	60	0.052
extrinsic apoptotic signaling pathway	GO:0097191	3	0.052
spinal cord radial glial cell differentiation	GO:0021531	2	0.052
cell part morphogenesis	GO:0032990	246	0.052
cellular response to extracellular stimulus	GO:0031668	2	0.051
embryonic skeletal joint morphogenesis	GO:0060272	3	0.051
canonical wnt signaling pathway	GO:0060070	48	0.051
macromolecule catabolic process	GO:0009057	15	0.050
lipid storage	GO:0019915	1	0.050
nucleic acid templated transcription	GO:0097659	181	0.050	Mouse Fly
organ formation	GO:0048645	17	0.050
wound healing	GO:0042060	90	0.050
urogenital system development	GO:0001655	97	0.050
specification of organ position	GO:0010159	3	0.049
kidney vasculature development	GO:0061440	2	0.049
positive regulation of protein deacetylation	GO:0090312	1	0.048
regulation of multicellular organism growth	GO:0040014	4	0.048
oligodendrocyte cell fate specification	GO:0021778	4	0.048
apoptotic signaling pathway	GO:0097190	23	0.047
response to chemical	GO:0042221	320	0.047	Zebrafish
cranial ganglion development	GO:0061550	3	0.047
adult behavior	GO:0030534	2	0.047
inner ear receptor cell fate commitment	GO:0060120	4	0.046
embryonic hemopoiesis	GO:0035162	53	0.046
forebrain neuron fate commitment	GO:0021877	1	0.046
single organism transport	GO:0044765	206	0.046
positive regulation of nucleic acid templated transcription	GO:1903508	57	0.046
hematopoietic progenitor cell differentiation	GO:0002244	23	0.046
endodermal cell differentiation	GO:0035987	19	0.045
embryonic camera type eye formation	GO:0060900	10	0.045
regulation of response to external stimulus	GO:0032101	31	0.045
somite development	GO:0061053	96	0.045
myeloid cell homeostasis	GO:0002262	56	0.044
negative regulation of signaling	GO:0023057	96	0.044	Mouse
heterocycle biosynthetic process	GO:0018130	215	0.044	Mouse Fly
wnt signaling pathway involved in somitogenesis	GO:0090244	2	0.043
regulation of signal transduction by p53 class mediator	GO:1901796	9	0.043
negative regulation of apoptotic process	GO:0043066	55	0.043
dendrite development	GO:0016358	9	0.043
positive regulation of response to stimulus	GO:0048584	80	0.043	Zebrafish
neural tube development	GO:0021915	62	0.043	Mouse
forebrain generation of neurons	GO:0021872	14	0.042
nucleocytoplasmic transport	GO:0006913	4	0.042
regulation of cysteine type endopeptidase activity involved in apoptotic process	GO:0043281	20	0.042
aging	GO:0007568	2	0.042
positive regulation of skeletal muscle tissue development	GO:0048643	1	0.042
negative regulation of smoothened signaling pathway	GO:0045879	6	0.041
homeostatic process	GO:0042592	142	0.041
invagination involved in gastrulation with mouth forming second	GO:0055109	1	0.041
hindbrain development	GO:0030902	91	0.040
regulation of protein import into nucleus	GO:0042306	2	0.040
axial mesoderm structural organization	GO:0048331	2	0.040
medial fin morphogenesis	GO:0035141	14	0.040
melanocyte differentiation	GO:0030318	26	0.039
mesendoderm migration	GO:0090133	2	0.039
hematopoietic stem cell differentiation	GO:0060218	20	0.039
regulation of transcription dna templated	GO:0006355	213	0.039	Zebrafish Mouse Fly
bmp signaling pathway involved in determination of left right symmetry	GO:0003154	14	0.039	Zebrafish
endocrine system development	GO:0035270	65	0.039
retina homeostasis	GO:0001895	12	0.038
cellular response to chemical stimulus	GO:0070887	157	0.038	Zebrafish
regulation of wnt signaling pathway involved in digestive tract morphogenesis	GO:2000056	2	0.038
optic placode formation	GO:0001743	4	0.038
positive regulation of biological process	GO:0048518	253	0.038	Zebrafish
nephron epithelium morphogenesis	GO:0072088	1	0.038
atrial ventricular junction remodeling	GO:0003294	2	0.037
convergent extension	GO:0060026	118	0.037
auditory receptor cell differentiation	GO:0042491	15	0.037
germ line stem cell maintenance	GO:0030718	2	0.036
liver development	GO:0001889	96	0.036
heart valve formation	GO:0003188	4	0.036
regulation of protein targeting	GO:1903533	2	0.036
regulation of cell proliferation involved in heart morphogenesis	GO:2000136	2	0.036
telencephalon development	GO:0021537	14	0.036
neural plate pattern specification	GO:0060896	12	0.035
proximal tubule development	GO:0072014	3	0.035
positive regulation of reproductive process	GO:2000243	2	0.035
stem cell development	GO:0048864	82	0.034	Human
positive regulation of biosynthetic process	GO:0009891	68	0.034
cell cycle g1 s phase transition	GO:0044843	1	0.034
oligodendrocyte differentiation	GO:0048709	23	0.034
positive regulation of nucleobase containing compound metabolic process	GO:0045935	69	0.034
cellular component biogenesis	GO:0044085	178	0.034
phagocytosis	GO:0006909	3	0.034
brain development	GO:0007420	293	0.034
positive regulation of gene expression	GO:0010628	71	0.034
positive regulation of embryonic development	GO:0040019	3	0.033
negative regulation of granulocyte chemotaxis	GO:0071623	3	0.033
cellular component assembly involved in morphogenesis	GO:0010927	107	0.033
regulation of ectodermal cell fate specification	GO:0042665	2	0.033
cell proliferation involved in heart morphogenesis	GO:0061323	2	0.033
positive regulation of muscle tissue development	GO:1901863	1	0.033
positive regulation of rna biosynthetic process	GO:1902680	57	0.032
programmed cell death	GO:0012501	119	0.032
establishment of melanosome localization	GO:0032401	19	0.032
leukocyte proliferation	GO:0070661	1	0.032
anatomical structure arrangement	GO:0048532	2	0.032
proteasomal protein catabolic process	GO:0010498	2	0.031
palate development	GO:0060021	8	0.031
neuron development	GO:0048666	262	0.031
heart contraction	GO:0060047	71	0.031
pronephros morphogenesis	GO:0072114	14	0.031
tissue remodeling	GO:0048771	4	0.031
stem cell division	GO:0017145	1	0.030
retinoid metabolic process	GO:0001523	15	0.030
face morphogenesis	GO:0060325	6	0.030
positive regulation of macromolecule biosynthetic process	GO:0010557	59	0.029
columnar cuboidal epithelial cell differentiation	GO:0002065	38	0.029
neuron fate commitment	GO:0048663	26	0.029
positive regulation of translation	GO:0045727	1	0.029
nerve development	GO:0021675	45	0.029
regulation of syncytium formation by plasma membrane fusion	GO:0060142	2	0.029
striated muscle cell differentiation	GO:0051146	129	0.029
rna biosynthetic process	GO:0032774	181	0.028	Mouse Fly
negative chemotaxis	GO:0050919	1	0.028
regulation of cell cycle	GO:0051726	52	0.028
semicircular canal development	GO:0060872	24	0.028
negative regulation of cell communication	GO:0010648	96	0.028	Mouse
endocrine hormone secretion	GO:0060986	2	0.028
taxis	GO:0042330	109	0.028
nuclear import	GO:0051170	3	0.028
paraxial mesoderm development	GO:0048339	8	0.028
endocardial cushion development	GO:0003197	6	0.028
pigmentation	GO:0043473	85	0.028
g1 s transition of mitotic cell cycle	GO:0000082	1	0.028
regulation of cellular response to stress	GO:0080135	20	0.028
cell projection organization	GO:0030030	284	0.028
regulation of response to oxidative stress	GO:1902882	2	0.027
kidney vasculature morphogenesis	GO:0061439	1	0.027
nephric duct morphogenesis	GO:0072178	7	0.027
morphogenesis of an epithelial fold	GO:0060571	1	0.027
dna damage response signal transduction by p53 class mediator	GO:0030330	5	0.027
positive regulation of cellular metabolic process	GO:0031325	94	0.027
regulation of mesenchymal cell proliferation	GO:0010464	1	0.026
androgen metabolic process	GO:0008209	2	0.026
segmentation	GO:0035282	97	0.026
dna templated transcription elongation	GO:0006354	3	0.026
regulation of activin receptor signaling pathway	GO:0032925	5	0.026
nose development	GO:0043584	3	0.026
negative regulation of anterior neural cell fate commitment of the neural plate	GO:0022001	1	0.026
peripheral nervous system development	GO:0007422	55	0.026
embryonic digestive tract morphogenesis	GO:0048557	3	0.026
positive regulation of transcription elongation from rna polymerase ii promoter	GO:0032968	1	0.025
negative regulation of sequence specific dna binding transcription factor activity	GO:0043433	2	0.025
regulation of biomineral tissue development	GO:0070167	2	0.025
axis elongation	GO:0003401	31	0.025
mononuclear cell proliferation	GO:0032943	1	0.025
retinal rod cell development	GO:0046548	4	0.025
negative regulation of neuron projection regeneration	GO:0070571	4	0.024
establishment of cell polarity involved in mesendodermal cell migration	GO:0003369	1	0.024
embryonic epithelial tube formation	GO:0001838	17	0.024
regulation of binding	GO:0051098	3	0.024
multicellular organismal response to stress	GO:0033555	2	0.024
regulation of establishment of planar polarity	GO:0090175	4	0.024
lateral line ganglion development	GO:0048890	2	0.024
negative regulation of metabolic process	GO:0009892	86	0.024	Mouse Fly
cardioblast migration to the midline involved in heart field formation	GO:0060975	7	0.024

gsc disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

	Disease	DO term ID	Size	Probability	Func Analog Org
	disease of anatomical entity	DOID:7	0	0.048
	nervous system disease	DOID:863	0	0.037

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Danio rerio

gsc

gsc biological process predictions

gsc disease predictions

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