Danio rerio

0 known processes

pcdh1a6

protocadherin 1 alpha 6

(Aliases: DrPcdh1ab4)

pcdh1a6 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
nuclear transportGO:005116940.167
protein localization to nucleusGO:003450430.088
stem cell maintenanceGO:001982740.047
regulation of multicellular organism growthGO:004001440.046
establishment of protein localization to organelleGO:007259440.046
adult behaviorGO:003053420.046
protein targeting to nucleusGO:004474430.045
nucleocytoplasmic transportGO:000691340.045
agingGO:000756820.044
positive regulation of transportGO:005105020.043
multicellular organism growthGO:003526440.043
organic cyclic compound metabolic processGO:19013603010.043
maintenance of locationGO:005123540.042
regulation of nucleocytoplasmic transportGO:004682220.041
larval developmentGO:000216420.040
protein importGO:001703830.040
regulation of dna templated transcription in response to stressGO:004362000.038
organic substance biosynthetic processGO:19015762890.037
cellular macromolecule metabolic processGO:00442603910.037
regulation of protein transportGO:005122330.035
extrinsic apoptotic signaling pathwayGO:009719130.035
regulation of establishment of protein localizationGO:007020140.035
regulation of cytoplasmic transportGO:190364940.035
regulation of multicellular organismal processGO:00512392770.035
cellular aromatic compound metabolic processGO:00067252950.034
single organism nuclear importGO:190259330.034
amine metabolic processGO:000930820.033
nucleobase containing compound metabolic processGO:00061392740.033
positive regulation of cell cycleGO:004578730.033
protein import into nucleusGO:000660630.033
regulation of transcription from rna polymerase ii promoter in response to stressGO:004361800.033
phospholipase c activating g protein coupled receptor signaling pathwayGO:000720020.033
transcription dna templatedGO:00063511810.033
regulation of sequestering of calcium ionGO:005128240.032
positive regulation of protein complex assemblyGO:003133420.032
cellular amine metabolic processGO:004410620.032
digestive tract morphogenesisGO:00485462310.032
cell surface receptor signaling pathwayGO:00071663250.032
oocyte maturationGO:000155640.032
regulation of meiotic cell cycleGO:005144510.032
stem cell divisionGO:001714510.031
positive regulation of cellular component biogenesisGO:004408930.031
heterocycle biosynthetic processGO:00181302150.031
signal transductionGO:00071654550.031
nuclear importGO:005117030.031
peptidyl serine phosphorylationGO:001810510.031
cellular biosynthetic processGO:00442492860.030
cellular component movementGO:00069283350.030
macromolecule biosynthetic processGO:00090592270.030
response to drugGO:004249330.030
response to external stimulusGO:00096052640.030
sensory organ developmentGO:00074233930.030
regulation of protein complex assemblyGO:004325430.030
embryonic organ morphogenesisGO:00485622740.030
regulation of bindingGO:005109830.029
sequestering of calcium ionGO:005120830.029
meiotic cell cycle processGO:190304630.029
regulation of reproductive processGO:200024140.029
regulation of macromolecule metabolic processGO:00602553170.029
cellular amino acid metabolic processGO:000652070.029
single organism metabolic processGO:00447102170.028
autophagyGO:000691440.028
nucleic acid metabolic processGO:00903042440.028
digestive system developmentGO:00551232890.028
regulation of extrinsic apoptotic signaling pathwayGO:200123630.028
regulation of protein localization to nucleusGO:190018020.027
cellular nitrogen compound metabolic processGO:00346412900.027
tissue remodelingGO:004877140.027
regulation of metal ion transportGO:001095940.027
regulation of mrna processingGO:005068430.027
nucleobase containing compound biosynthetic processGO:00346542050.027
oxoacid metabolic processGO:0043436310.027
regulation of metabolic processGO:00192223590.027
regulation of cellular amine metabolic processGO:003323800.027
negative regulation of protein phosphorylationGO:000193340.027
head developmentGO:00603223030.027
positive regulation of catabolic processGO:000989640.026
negative regulation of sequestering of calcium ionGO:005128340.026
regulation of dna replicationGO:000627530.026
cellular response to nutrient levelsGO:003166920.026
meiotic nuclear divisionGO:000712640.026
rna metabolic processGO:00160702190.026
heterocycle metabolic processGO:00464832900.026
cellular response to external stimulusGO:007149620.026
regulation of nitrogen compound metabolic processGO:00511712510.026
cellular response to extracellular stimulusGO:003166820.025
regulation of protein targetingGO:190353320.025
gastrulationGO:00073692080.025
organic cyclic compound biosynthetic processGO:19013622230.025
regulation of synapse organizationGO:005080730.025
regulation of nucleobase containing compound metabolic processGO:00192192500.025
nuclear exportGO:005116810.025
nucleic acid templated transcriptionGO:00976591810.025
regulation of cellular amino acid metabolic processGO:000652100.025
regulation of primary metabolic processGO:00800903110.025
regulation of autophagyGO:001050630.024
determination of bilateral symmetryGO:00098552040.024
regulation of gene expressionGO:00104682650.024
regulation of protein ubiquitinationGO:003139630.024
regulation of blood pressureGO:000821710.024
response to stressGO:00069502630.024
cellular nitrogen compound biosynthetic processGO:00442712180.024
cellular ketone metabolic processGO:0042180110.024
negative regulation of protein localization to nucleusGO:190018120.024
carboxylic acid metabolic processGO:0019752220.024
response to chemicalGO:00422213200.024
dorsal ventral pattern formationGO:00099531250.024
internal peptidyl lysine acetylationGO:001839320.024
skeletal system developmentGO:00015011810.024
rna biosynthetic processGO:00327741810.024
cell migrationGO:00164772370.023
peptidyl serine modificationGO:001820920.023
lipid storageGO:001991510.023
proteasomal protein catabolic processGO:001049820.023
regulation of biological qualityGO:00650082630.023
modification dependent protein catabolic processGO:001994130.023
regulation of protein catabolic processGO:004217610.023
sequestering of metal ionGO:005123830.023
regulation of i kappab kinase nf kappab signalingGO:004312240.023
regulation of transcription dna templatedGO:00063552130.023
regulation of protein import into nucleusGO:004230620.023
cell substrate adhesionGO:003158940.022
regulation of rna metabolic processGO:00512522240.022
somatic stem cell maintenanceGO:003501910.022
cell cycle g1 s phase transitionGO:004484310.022
regulation of embryonic developmentGO:0045995470.022
blood vessel developmentGO:00015682460.022
regulation of response to nutrient levelsGO:003210710.022
sensory organ morphogenesisGO:00905962000.022
proteolysis involved in cellular protein catabolic processGO:005160330.022
cellular response to starvationGO:000926710.022
organonitrogen compound metabolic processGO:1901564740.022
gene expressionGO:00104672520.022
regulation of multicellular organismal developmentGO:20000262230.022
positive regulation of cytosolic calcium ion concentrationGO:000720440.022
digestive tract developmentGO:00485652650.021
organic acid metabolic processGO:0006082310.021
aromatic compound biosynthetic processGO:00194382170.021
gtp metabolic processGO:004603940.021
protein acetylationGO:000647320.021
regulation of cellular ketone metabolic processGO:001056570.021
peptidyl lysine acetylationGO:001839420.021
modification dependent macromolecule catabolic processGO:004363230.021
stem cell proliferationGO:007208940.021
cell motilityGO:00488702440.021
positive regulation of reproductive processGO:200024320.021
synaptic growth at neuromuscular junctionGO:005112420.021
regulation of biosynthetic processGO:00098892500.021
negative regulation of protein kinase activityGO:000646940.021
positive regulation of cellular catabolic processGO:003133130.021
ubiquitin dependent protein catabolic processGO:000651130.021
response to organic substanceGO:00100331530.021
negative regulation of biological processGO:00485193040.021
positive regulation of canonical wnt signaling pathwayGO:009026340.021
establishment of localizationGO:00512342440.020
regulation of macromolecule biosynthetic processGO:00105562250.020
positive regulation of cytoskeleton organizationGO:005149530.020
positive regulation of translationGO:004572710.020
regulation of response to cytokine stimulusGO:006075930.020
regulation of nucleic acid templated transcriptionGO:19035062130.020
cell matrix adhesionGO:000716040.020
inner ear developmentGO:00488391260.020
system processGO:00030081850.020
regulation of rna biosynthetic processGO:20011412130.020
cellular response to lipopolysaccharideGO:007122230.020
vasculature developmentGO:00019442780.020
calcium ion transport into cytosolGO:006040230.020
biosynthetic processGO:00090582940.020
antimicrobial humoral responseGO:001973020.020
regulation of signalingGO:00230512350.020
regulation of erk1 and erk2 cascadeGO:007037240.020
internal protein amino acid acetylationGO:000647520.020
nitrogen compound metabolic processGO:00068073190.020
morphogenesis of an epitheliumGO:00020093330.020
protein metabolic processGO:00195381830.020
regulation of cellular metabolic processGO:00313233200.020
embryonic organ developmentGO:00485683810.020
immune system processGO:00023762410.020
response to biotic stimulusGO:0009607970.019
meiotic chromosome segregationGO:004513230.019
phagocytosisGO:000690930.019
negative regulation of map kinase activityGO:004340720.019
negative regulation of nucleocytoplasmic transportGO:004682320.019
positive regulation of cellular amino acid metabolic processGO:004576400.019
negative regulation of mapk cascadeGO:004340940.019
cellular response to biotic stimulusGO:007121630.019
erk1 and erk2 cascadeGO:007037140.019
negative regulation of intracellular transportGO:003238730.019
negative regulation of response to cytokine stimulusGO:006076120.019
regulation of cell activationGO:005086510.019
regulation of blood vessel sizeGO:005088020.019
negative regulation of protein serine threonine kinase activityGO:007190120.019
cellular response to reactive oxygen speciesGO:003461420.019
specification of symmetryGO:00097992040.019
cortical cytoskeleton organizationGO:003086510.019
i kappab kinase nf kappab signalingGO:000724940.018
protein polymerizationGO:005125840.018
regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:200123910.018
determination of left right symmetryGO:00073681790.018
regulation of reactive oxygen species metabolic processGO:200037720.018
ribonucleoside monophosphate catabolic processGO:000915840.018
cellular protein catabolic processGO:004425740.018
blood circulationGO:0008015870.018
regulation of intracellular protein transportGO:003315730.018
gtp catabolic processGO:000618420.018
response to other organismGO:0051707970.018
transcription from rna polymerase ii promoterGO:0006366800.018
regulation of response to extracellular stimulusGO:003210410.018
somatic muscle developmentGO:000752540.018
regulation of response to stimulusGO:00485832690.018
germ line stem cell divisionGO:004207810.018
cellular component biogenesisGO:00440851780.018
regulation of protein bindingGO:004339330.018
symbiosis encompassing mutualism through parasitismGO:004440340.018
regulation of cellular biosynthetic processGO:00313262450.018
regulation of cell communicationGO:00106462320.018
regionalizationGO:00030022740.017
g1 s transition of mitotic cell cycleGO:000008210.017
negative regulation of sequence specific dna binding transcription factor activityGO:004343320.017
positive regulation of cellular amine metabolic processGO:003324000.017
cellular macromolecule biosynthetic processGO:00346452240.017
brain developmentGO:00074202930.017
response to hydrogen peroxideGO:004254230.017
neuron developmentGO:00486662620.017
blood vessel morphogenesisGO:00485142160.017
protein acylationGO:004354330.017
wound healingGO:0042060900.017
cellular component morphogenesisGO:00329893360.017
guanosine containing compound metabolic processGO:190106840.017
guanosine containing compound catabolic processGO:190106920.017
positive regulation of erk1 and erk2 cascadeGO:007037420.017
circulatory system processGO:0003013870.017
positive regulation of biological processGO:00485182530.017
regulation of peptidyl tyrosine phosphorylationGO:005073010.017
release of sequestered calcium ion into cytosolGO:005120930.017
germ line stem cell maintenanceGO:003071820.017
negative regulation of cytokine productionGO:000181810.017
cellular response to molecule of bacterial originGO:007121930.017
macroautophagyGO:001623610.017
positive regulation of apoptotic signaling pathwayGO:200123510.017
regulation of signal transductionGO:00099662250.016
response to carbohydrateGO:000974330.016
extrinsic apoptotic signaling pathway in absence of ligandGO:009719210.016
smooth muscle contractionGO:000693920.016
negative regulation of secretionGO:005104820.016
positive regulation of dna metabolic processGO:005105410.016
negative regulation of protein import into nucleusGO:004230820.016
cellular protein metabolic processGO:00442671290.016
regulation of anatomical structure morphogenesisGO:00226031300.016
peptidyl threonine phosphorylationGO:001810710.016
regulation of synaptic growth at neuromuscular junctionGO:000858210.016
ameboidal type cell migrationGO:00016671430.016
regulation of developmental processGO:00507932470.016
embryo development ending in birth or egg hatchingGO:00097922710.016
protein localization to plasma membraneGO:007265910.016
small molecule metabolic processGO:0044281770.016
negative regulation of cytoplasmic transportGO:190365020.016
regulation of tube sizeGO:003515020.016
hard palate developmentGO:006002240.016
xenobiotic metabolic processGO:000680540.016
secondary metabolic processGO:001974830.016
negative regulation of kinase activityGO:003367340.016
phagocytosis engulfmentGO:000691110.016
regulation of oocyte developmentGO:006028130.016
cytosolic calcium ion transportGO:006040130.016
regulation of response to oxidative stressGO:190288220.016
catechol containing compound metabolic processGO:000971220.016
sensory perception of painGO:001923310.016
cellular response to organic substanceGO:00713101050.015
multi organism processGO:00517041340.015
negative regulation of extrinsic apoptotic signaling pathwayGO:200123720.015
signal transduction in absence of ligandGO:003803410.015
negative regulation of cellular catabolic processGO:003133030.015
response to glucoseGO:000974930.015
response to uvGO:000941130.015
cytokinesisGO:000091030.015
membrane invaginationGO:001032410.015
camera type eye developmentGO:00430102220.015
developmental growthGO:00485891660.015
negative regulation of cellular processGO:00485232830.015
angiogenesisGO:00015251580.015
response to external biotic stimulusGO:0043207970.015
spindle assemblyGO:005122520.015
tube morphogenesisGO:00352393490.015
negative regulation of catabolic processGO:000989530.015
proteasome mediated ubiquitin dependent protein catabolic processGO:004316120.015
single organism membrane fusionGO:004480120.015
regulation of cytokine productionGO:000181730.015
regulation of stem cell differentiationGO:200073640.015
positive regulation of protein polymerizationGO:003227320.015
transportGO:00068102200.015
leukocyte proliferationGO:007066110.015
chordate embryonic developmentGO:00430092710.015
eye developmentGO:00016542770.015
positive regulation of purine nucleotide catabolic processGO:003312310.015
carbohydrate biosynthetic processGO:001605110.015
membrane fusionGO:006102520.015
development of primary female sexual characteristicsGO:004654540.015
pathway restricted smad protein phosphorylationGO:006038910.015
actin polymerization or depolymerizationGO:000815420.015
ear developmentGO:00435831270.015
organelle fusionGO:004828430.015
regulation of wound healingGO:006104120.014
regulation of response to biotic stimulusGO:000283120.014
chemosensory behaviorGO:000763510.014
positive regulation of cell activationGO:005086710.014
regulation of protein polymerizationGO:003227120.014
embryonic heart tube developmentGO:00350501330.014
reactive nitrogen species metabolic processGO:200105700.014
purine ribonucleoside monophosphate catabolic processGO:000916940.014
defense response to fungusGO:005083220.014
protein homooligomerizationGO:005126030.014
regulation of gtp catabolic processGO:003312420.014
heart morphogenesisGO:00030071560.014
positive regulation of multi organism processGO:004390230.014
response to glucocorticoidGO:005138410.014
atp catabolic processGO:000620040.014
rhombomere 5 developmentGO:002157140.014
muscle structure developmentGO:00610611960.014
positive regulation of nitrogen compound metabolic processGO:0051173690.014
locomotor rhythmGO:004547530.014
localization of cellGO:00516742440.014
regulation of cellular macromolecule biosynthetic processGO:20001122220.014
regulation of transcription from rna polymerase ii promoterGO:00063571140.014
regulation of muscle contractionGO:000693730.014
positive regulation of cellular processGO:00485222010.014
cellular response to growth factor stimulusGO:0071363390.014
anterior posterior pattern specificationGO:00099521520.014
estrogen metabolic processGO:000821020.014
determination of heart left right asymmetryGO:00613711170.014
regulation of nucleoside metabolic processGO:000911820.014
sensory system developmentGO:0048880760.014
regulation of cellular response to oxidative stressGO:190040720.014
cellular response to chemical stimulusGO:00708871570.014
actin filament based movementGO:003004810.014
cognitionGO:005089010.014
establishment of synaptic vesicle localizationGO:009748010.014
alternative mrna splicing via spliceosomeGO:000038010.014
interspecies interaction between organismsGO:004441940.014
compound eye developmentGO:004874920.014
cellular response to oxygen levelsGO:007145310.014
bmp signaling pathwayGO:0030509520.014
intracellular signal transductionGO:0035556850.014
female sex differentiationGO:004666040.014
nuclear migrationGO:000709730.013
olfactory bulb developmentGO:002177240.013
connective tissue developmentGO:0061448990.013
single organism localizationGO:19025782250.013
b cell activationGO:004211320.013
cellular protein modification processGO:00064641000.013
regulation of alternative mrna splicing via spliceosomeGO:000038110.013
somite developmentGO:0061053960.013
regulation of protein modification by small protein conjugation or removalGO:190332030.013
actin filament polymerizationGO:003004120.013
regulation of cell projection assemblyGO:006049140.013
lymphocyte proliferationGO:004665110.013
female gonad developmentGO:000858540.013
small molecule catabolic processGO:004428230.013
cellular carbohydrate metabolic processGO:004426240.013
positive regulation of ras protein signal transductionGO:004657910.013
positive regulation of secretionGO:005104710.013
exocytosisGO:000688710.013
negative regulation of protein complex assemblyGO:003133310.013
positive regulation of synaptic growth at neuromuscular junctionGO:004588710.013
transmembrane transportGO:00550851200.013
regulation of purine nucleotide catabolic processGO:003312120.013
rna localizationGO:000640340.013
cytoskeleton dependent cytokinesisGO:006164030.013
heart developmentGO:00075073130.013
regulation of calcium ion transportGO:005192420.013
regulation of localizationGO:00328791040.013
lateral line system developmentGO:0048925760.013
macromolecule modificationGO:00434121110.013
positive regulation of cell adhesionGO:004578510.013
sensory perception of chemical stimulusGO:000760630.013
regulation of synaptic plasticityGO:004816710.013
protein secretionGO:000930610.013
negative regulation of nuclear divisionGO:005178430.013
cardiac atrium developmentGO:000323040.013
response to corticosteroidGO:003196010.013
olfactory lobe developmentGO:002198840.013
g protein coupled receptor signaling pathwayGO:0007186740.013
regulation of synapse assemblyGO:005196330.013
cellular response to xenobiotic stimulusGO:0071466350.013
odontogenesis of dentin containing toothGO:004247510.012
purine nucleoside monophosphate catabolic processGO:000912840.012
positive regulation of secretion by cellGO:190353210.012
catecholamine metabolic processGO:000658420.012
response to hexoseGO:000974630.012
heart loopingGO:0001947940.012
positive regulation of cytokine productionGO:000181920.012
embryonic heart tube morphogenesisGO:00031431080.012
negative regulation of intracellular protein transportGO:009031730.012
hepaticobiliary system developmentGO:0061008980.012
protein complex disassemblyGO:004324110.012
intestinal absorptionGO:005089220.012
nucleoside monophosphate catabolic processGO:000912540.012
cortical actin cytoskeleton organizationGO:003086610.012
regulation of photoreceptor cell differentiationGO:004653220.012
vacuolar transportGO:000703420.012
regulation of ion transmembrane transporter activityGO:003241220.012
notochord developmentGO:0030903540.012
regulation of systemic arterial blood pressureGO:000307310.012
septum transversum developmentGO:000334340.012
regulation of nucleotide catabolic processGO:003081120.012
regulation of transporter activityGO:003240920.012
positive regulation of blood circulationGO:190352420.012
primary neural tube formationGO:001402010.012
response to superoxideGO:000030320.012
negative regulation of signalingGO:0023057960.012
cellular localizationGO:0051641970.012
somitogenesisGO:0001756870.012
multi organism cellular processGO:004476420.012
cartilage developmentGO:0051216960.012
positive regulation of myeloid cell differentiationGO:004563920.012
negative regulation of epithelial cell proliferationGO:005068010.012
response to xenobiotic stimulusGO:0009410450.012
organelle assemblyGO:00709251100.012
axonogenesisGO:00074091520.012
response to abiotic stimulusGO:00096281220.012
transmembrane receptor protein serine threonine kinase signaling pathwayGO:0007178680.012
phosphatidylinositol 3 kinase signalingGO:001406520.012
alcohol biosynthetic processGO:004616520.012
mononuclear cell proliferationGO:003294310.012
regulation of symbiosis encompassing mutualism through parasitismGO:004390310.012
enzyme linked receptor protein signaling pathwayGO:00071671060.012
female meiotic divisionGO:000714320.012
regenerationGO:0031099910.012
positive regulation of nucleobase containing compound metabolic processGO:0045935690.012
positive regulation of nucleotide catabolic processGO:003081310.012
mitochondrion organizationGO:000700540.012
positive regulation of oocyte developmentGO:006028210.012
response to monosaccharideGO:003428430.012
double strand break repairGO:000630230.012
single fertilizationGO:000733830.012
regulation of organelle assemblyGO:190211540.012
positive regulation of immune effector processGO:000269930.012
macromolecular complex disassemblyGO:003298410.012
negative regulation of autophagyGO:001050710.011
regulation of microtubule cytoskeleton organizationGO:007050730.011
response to topologically incorrect proteinGO:003596620.011
positive regulation of chromosome organizationGO:200125210.011
positive regulation of leukocyte differentiationGO:190210710.011
viral processGO:001603210.011
epithelial tube morphogenesisGO:00605621480.011
regulation of epithelial cell proliferationGO:005067830.011
lipid homeostasisGO:005508830.011
regulation of sodium ion transportGO:000202820.011
neuromuscular synaptic transmissionGO:000727420.011
gland developmentGO:00487321430.011
cellular response to decreased oxygen levelsGO:003629410.011
positive regulation of gtpase activityGO:004354710.011
establishment of protein localization to plasma membraneGO:009000210.011
golgi vesicle transportGO:004819330.011
hematopoietic or lymphoid organ developmentGO:00485341910.011
single organism organelle organizationGO:19025891990.011
regulation of mesenchymal cell proliferationGO:001046410.011
cell cycle arrestGO:000705010.011
regulation of syncytium formation by plasma membrane fusionGO:006014220.011
response to woundingGO:00096111160.011
single organism biosynthetic processGO:0044711710.011
regulation of jun kinase activityGO:004350630.011
negative regulation of defense responseGO:003134820.011
p38mapk cascadeGO:003806610.011
glial cell proliferationGO:001400940.011
growthGO:00400071740.011
protein heterooligomerizationGO:005129110.011
regulation of gtpase activityGO:004308720.011
nitric oxide biosynthetic processGO:000680920.011
protein modification processGO:00362111000.011
periodic partitioningGO:000736510.011
phosphorus metabolic processGO:00067931090.011
pyrimidine containing compound metabolic processGO:007252730.011
regulation of inflammatory responseGO:005072720.011
phosphate containing compound metabolic processGO:00067961080.011
homeostatic processGO:00425921420.011
positive regulation of transcription dna templatedGO:0045893570.011
response to endogenous stimulusGO:0009719830.011
cell migration involved in gastrulationGO:0042074790.011
synaptic vesicle localizationGO:009747910.011
microtubule polymerization or depolymerizationGO:003110930.011
negative regulation of macromolecule metabolic processGO:0010605760.011
cellular component assembly involved in morphogenesisGO:00109271070.011

pcdh1a6 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.045
cardiovascular system diseaseDOID:128700.026
musculoskeletal system diseaseDOID:1700.025
cancerDOID:16200.016
disease of cellular proliferationDOID:1456600.016
nervous system diseaseDOID:86300.015
muscular diseaseDOID:008000000.015
muscle tissue diseaseDOID:6600.015
myopathyDOID:42300.014
organ system cancerDOID:005068600.014
disease of metabolismDOID:001466700.012
inherited metabolic disorderDOID:65500.012