Danio rerio

0 known processes

ctdsp1

CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1

(Aliases: fj83f12,wu:fj83f12,im:7141428,zgc:113169,MGC113169)

ctdsp1 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
transportGO:00068102200.126
positive regulation of biological processGO:00485182530.117
regulation of cellular metabolic processGO:00313233200.109
Human
regulation of primary metabolic processGO:00800903110.106
Human
organelle fusionGO:004828430.105
cellular macromolecule metabolic processGO:00442603910.095
Human
positive regulation of transportGO:005105020.090
membrane fusionGO:006102520.090
regulation of protein catabolic processGO:004217610.087
organelle organizationGO:00069962270.087
phagocytosisGO:000690930.079
locomotionGO:00400113130.079
agingGO:000756820.078
cellular protein catabolic processGO:004425740.075
positive regulation of cellular catabolic processGO:003133130.073
cellular aromatic compound metabolic processGO:00067252950.072
Human
nucleobase containing compound metabolic processGO:00061392740.068
Human
immune system processGO:00023762410.068
regulation of biosynthetic processGO:00098892500.068
Human
single organism organelle organizationGO:19025891990.067
negative regulation of biological processGO:00485193040.067
generation of neuronsGO:00486993850.067
Zebrafish
positive regulation of catabolic processGO:000989640.064
cellular macromolecule biosynthetic processGO:00346452240.064
Human
regulation of macromolecule metabolic processGO:00602553170.063
Human
establishment of localizationGO:00512342440.063
single organism membrane fusionGO:004480120.062
cellular nitrogen compound metabolic processGO:00346412900.058
Human
nucleic acid templated transcriptionGO:00976591810.057
Human
cellular component biogenesisGO:00440851780.057
biosynthetic processGO:00090582940.056
Human
response to external stimulusGO:00096052640.056
cell motilityGO:00488702440.055
cellular component movementGO:00069283350.055
single organism localizationGO:19025782250.054
proteasome mediated ubiquitin dependent protein catabolic processGO:004316120.054
cell morphogenesisGO:00009022890.054
response to chemicalGO:00422213200.054
single organism metabolic processGO:00447102170.054
single organism transportGO:00447652060.054
positive regulation of cellular processGO:00485222010.053
organic substance biosynthetic processGO:19015762890.053
Human
heterocycle metabolic processGO:00464832900.053
Human
cellular component assemblyGO:00226071700.053
nucleic acid metabolic processGO:00903042440.053
Human
organic cyclic compound metabolic processGO:19013603010.050
Human
lipid storageGO:001991510.049
negative regulation of protein phosphorylationGO:000193340.048
regulation of response to stimulusGO:00485832690.048
regulation of anatomical structure morphogenesisGO:00226031300.047
guanosine containing compound catabolic processGO:190106920.046
cell part morphogenesisGO:00329902460.046
cell migrationGO:00164772370.046
regulation of metabolic processGO:00192223590.045
Human
regulation of multicellular organism growthGO:004001440.045
maintenance of locationGO:005123540.044
lipid catabolic processGO:001604240.043
heterocycle biosynthetic processGO:00181302150.043
Human
cell projection morphogenesisGO:00488582440.043
macromolecule biosynthetic processGO:00090592270.043
Human
multicellular organism growthGO:003526440.043
modification dependent macromolecule catabolic processGO:004363230.043
enzyme linked receptor protein signaling pathwayGO:00071671060.042
establishment of protein localization to organelleGO:007259440.041
signal transductionGO:00071654550.041
localization of cellGO:00516742440.040
regulation of signal transductionGO:00099662250.040
rna metabolic processGO:00160702190.040
Human
guanosine containing compound metabolic processGO:190106840.039
stem cell proliferationGO:007208940.039
cytoskeleton dependent cytokinesisGO:006164030.038
regulation of nitrogen compound metabolic processGO:00511712510.038
Human
negative regulation of cellular processGO:00485232830.038
regulation of proteolysis involved in cellular protein catabolic processGO:190305010.037
regulation of biological qualityGO:00650082630.037
meiotic nuclear divisionGO:000712640.037
regulation of signalingGO:00230512350.036
regulation of cell shapeGO:000836010.036
positive regulation of cellular metabolic processGO:0031325940.036
cellular component morphogenesisGO:00329893360.036
establishment of synaptic vesicle localizationGO:009748010.036
neuron differentiationGO:00301823530.035
Zebrafish
positive regulation of gtp catabolic processGO:003312610.035
regulation of macromolecule biosynthetic processGO:00105562250.035
Human
regulation of cell communicationGO:00106462320.035
nitrogen compound metabolic processGO:00068073190.035
Human
regulation of rna metabolic processGO:00512522240.035
Human
single organism membrane organizationGO:0044802200.035
gtp catabolic processGO:000618420.034
proteolysis involved in cellular protein catabolic processGO:005160330.034
regulation of blood pressureGO:000821710.034
ubiquitin dependent protein catabolic processGO:000651130.034
autophagyGO:000691440.034
regulation of cellular protein catabolic processGO:190336210.033
regulation of multicellular organismal processGO:00512392770.033
developmental growthGO:00485891660.033
endosomal transportGO:001619720.033
regulation of developmental processGO:00507932470.032
aromatic compound biosynthetic processGO:00194382170.032
Human
regulation of gene expressionGO:00104682650.032
Human
positive regulation of cellular component biogenesisGO:004408930.032
positive regulation of metabolic processGO:00098931080.032
positive regulation of protein complex assemblyGO:003133420.032
cell projection organizationGO:00300302840.032
regulation of protein complex assemblyGO:004325430.031
gene expressionGO:00104672520.031
Human
regulation of cell developmentGO:00602841000.031
response to stressGO:00069502630.031
Yeast
cellular response to nutrient levelsGO:003166920.030
regulation of establishment of protein localizationGO:007020140.030
proteasomal protein catabolic processGO:001049820.030
gtp metabolic processGO:004603940.030
neuron projection developmentGO:00311751800.030
neuron developmentGO:00486662620.030
growthGO:00400071740.030
regulation of neurogenesisGO:0050767870.030
transcription from rna polymerase ii promoterGO:0006366800.030
Human
regulation of stem cell proliferationGO:007209120.030
neuroblast proliferationGO:000740520.029
blood vessel morphogenesisGO:00485142160.029
protein localization to plasma membraneGO:007265910.029
heart developmentGO:00075073130.029
positive regulation of cell communicationGO:0010647560.029
cellular biosynthetic processGO:00442492860.029
Human
cellular response to extracellular stimulusGO:003166820.029
cell morphogenesis involved in neuron differentiationGO:00486671630.029
cell morphogenesis involved in differentiationGO:00009041950.029
positive regulation of stress activated mapk cascadeGO:003287430.028
taxisGO:00423301090.028
regulation of multicellular organismal developmentGO:20000262230.028
organic substance transportGO:0071702580.028
regulation of cellular ketone metabolic processGO:001056570.028
cellular carbohydrate metabolic processGO:004426240.028
oxoacid metabolic processGO:0043436310.028
regulation of rna biosynthetic processGO:20011412130.027
Human
organic cyclic compound biosynthetic processGO:19013622230.027
Human
cellular response to starvationGO:000926710.027
homeostatic processGO:00425921420.027
neuron projection morphogenesisGO:00488121610.027
cellular protein metabolic processGO:00442671290.027
Human
protein localization to nucleusGO:003450430.027
synaptic vesicle localizationGO:009747910.027
determination of bilateral symmetryGO:00098552040.027
small molecule metabolic processGO:0044281770.027
head developmentGO:00603223030.026
cellular ketone metabolic processGO:0042180110.026
protein metabolic processGO:00195381830.026
Human
positive regulation of stress activated protein kinase signaling cascadeGO:007030430.025
regulation of wound healingGO:006104120.025
larval developmentGO:000216420.025
multi organism processGO:00517041340.025
cytokinesisGO:000091030.025
axon developmentGO:00615641660.025
protein heterooligomerizationGO:005129110.025
nucleobase containing compound biosynthetic processGO:00346542050.025
Human
positive regulation of gtpase activityGO:004354710.025
embryonic organ developmentGO:00485683810.025
extrinsic apoptotic signaling pathwayGO:009719130.025
regulation of nucleic acid templated transcriptionGO:19035062130.025
Human
embryonic organ morphogenesisGO:00485622740.025
regulation of localizationGO:00328791040.025
cellular response to external stimulusGO:007149620.024
cellular amine metabolic processGO:004410620.024
synaptic vesicle transportGO:004848910.024
regulation of gtp catabolic processGO:003312420.024
positive regulation of signal transductionGO:0009967560.023
positive regulation of cell cycleGO:004578730.023
membrane invaginationGO:001032410.023
nuclear transportGO:005116940.023
actin filament based movementGO:003004810.023
cellular nitrogen compound biosynthetic processGO:00442712180.023
Human
microtubule organizing center organizationGO:003102310.023
regulation of cell deathGO:00109411030.023
secondary metabolic processGO:001974830.023
regulation of reactive oxygen species metabolic processGO:200037720.023
cortical actin cytoskeleton organizationGO:003086610.023
exocytosisGO:000688710.023
axonogenesisGO:00074091520.023
peptidyl serine modificationGO:001820920.023
nucleocytoplasmic transportGO:000691340.023
negative regulation of protein kinase activityGO:000646940.022
peptidyl serine phosphorylationGO:001810510.022
deathGO:00162651210.022
positive regulation of signalingGO:0023056560.022
phosphorus metabolic processGO:00067931090.022
Human Yeast
regulation of dendrite developmentGO:005077330.022
protein complex subunit organizationGO:0071822460.022
chemotaxisGO:00069351040.021
regulation of intracellular signal transductionGO:1902531570.021
regulation of protein transportGO:005122330.021
positive regulation of purine nucleotide catabolic processGO:003312310.021
muscle structure developmentGO:00610611960.021
regulation of purine nucleotide catabolic processGO:003312120.021
positive regulation of macromolecule metabolic processGO:0010604930.021
carboxylic acid metabolic processGO:0019752220.021
cellular localizationGO:0051641970.021
stem cell maintenanceGO:001982740.021
neurotransmitter transportGO:000683620.020
rna biosynthetic processGO:00327741810.020
Human
regulation of cellular biosynthetic processGO:00313262450.020
Human
macromolecular complex subunit organizationGO:0043933740.020
specification of symmetryGO:00097992040.020
regulation of cellular carbohydrate metabolic processGO:001067540.020
regulation of glucose importGO:004632410.020
meiotic cell cycle processGO:190304630.020
regulation of cellular amino acid metabolic processGO:000652100.020
regulation of meiotic cell cycleGO:005144510.020
protein import into nucleusGO:000660630.020
positive regulation of cellular amine metabolic processGO:003324000.020
digestive system developmentGO:00551232890.020
response to carbohydrateGO:000974330.020
golgi vesicle transportGO:004819330.020
adult behaviorGO:003053420.019
amine metabolic processGO:000930820.019
regulation of cellular amine metabolic processGO:003323800.019
regulation of organ growthGO:004662030.019
response to hexoseGO:000974630.019
erk1 and erk2 cascadeGO:007037140.019
regulation of nucleotide catabolic processGO:003081120.019
positive regulation of nucleotide catabolic processGO:003081310.019
single organism nuclear importGO:190259330.019
lamellipodium assemblyGO:003003210.019
regulation of cellular macromolecule biosynthetic processGO:20001122220.019
Human
regulation of hormone secretionGO:004688320.019
response to organic substanceGO:00100331530.019
cellular response to chemical stimulusGO:00708871570.019
centrosome cycleGO:000709810.019
protein importGO:001703830.019
regulation of mrna processingGO:005068430.019
embryonic limb morphogenesisGO:003032620.018
brain developmentGO:00074202930.018
synaptic growth at neuromuscular junctionGO:005112420.018
phosphorylationGO:0016310690.018
regulation of locomotionGO:0040012550.018
cellular response to endogenous stimulusGO:0071495680.018
positive regulation of cytoskeleton organizationGO:005149530.018
response to woundingGO:00096111160.018
hemopoiesisGO:00300971830.018
positive regulation of map kinase activityGO:004340630.018
phagocytosis engulfmentGO:000691110.018
cellular amino acid metabolic processGO:000652070.018
determination of left right symmetryGO:00073681790.018
organic acid metabolic processGO:0006082310.018
mitotic cytokinesisGO:000028130.018
protein targeting to nucleusGO:004474430.018
sensory organ developmentGO:00074233930.018
regulation of carbohydrate biosynthetic processGO:004325510.018
tissue remodelingGO:004877140.018
positive regulation of jnk cascadeGO:004633030.018
cognitionGO:005089010.018
cortical cytoskeleton organizationGO:003086510.018
regulation of synapse organizationGO:005080730.018
glucose importGO:004632320.018
transcription dna templatedGO:00063511810.018
Human
lamellipodium organizationGO:009758110.017
response to monosaccharideGO:003428430.017
phosphate containing compound metabolic processGO:00067961080.017
Human Yeast
production of molecular mediator of immune responseGO:000244020.017
response to hormoneGO:0009725480.017
nuclear importGO:005117030.017
response to drugGO:004249330.017
regulation of cell sizeGO:0008361290.017
positive regulation of nitrogen compound metabolic processGO:0051173690.017
actin mediated cell contractionGO:007025210.017
centrosome organizationGO:005129710.017
regulation of cytoplasmic transportGO:190364940.017
regulation of erk1 and erk2 cascadeGO:007037240.017
positive regulation of response to stimulusGO:0048584800.017
regulation of receptor activityGO:001046920.017
regulation of nucleoside metabolic processGO:000911820.017
nuclear exportGO:005116810.017
adherens junction organizationGO:003433240.017
central nervous system developmentGO:00074173870.016
positive regulation of secretionGO:005104710.016
positive regulation of secretion by cellGO:190353210.016
stem cell divisionGO:001714510.016
cytokinetic processGO:003250620.016
regulation of filopodium assemblyGO:005148920.016
protein complex biogenesisGO:0070271300.016
regulation of cellular component organizationGO:0051128860.016
response to glucoseGO:000974930.016
blood vessel developmentGO:00015682460.016
ameboidal type cell migrationGO:00016671430.016
organonitrogen compound metabolic processGO:1901564740.016
macromolecular complex assemblyGO:0065003350.016
negative regulation of secretionGO:005104820.016
positive regulation of nucleoside metabolic processGO:004597910.016
regulation of transcription dna templatedGO:00063552130.016
Human
programmed cell deathGO:00125011190.016
digestive tract developmentGO:00485652650.016
cellular monovalent inorganic cation homeostasisGO:003000420.016
actin filament polymerizationGO:003004120.016
macromolecule modificationGO:00434121110.016
Human
purine ribonucleoside monophosphate catabolic processGO:000916940.016
immune system developmentGO:00025201910.016
carbohydrate biosynthetic processGO:001605110.016
regulation of cellular component movementGO:0051270550.016
macromolecule localizationGO:0033036540.016
establishment of localization in cellGO:0051649770.016
regulation of apoptotic processGO:0042981980.016
regulation of cytokine productionGO:000181730.016
hormone secretionGO:004687920.016
system processGO:00030081850.016
morphogenesis of an epitheliumGO:00020093330.016
cellular response to stressGO:0033554620.016
Yeast
spermatid differentiationGO:004851520.016
modification dependent protein catabolic processGO:001994130.015
regulation of synaptic plasticityGO:004816710.015
response to corticosteroidGO:003196010.015
regulation of synapse assemblyGO:005196330.015
regulation of gtpase activityGO:004308720.015
regulation of transportGO:0051049450.015
renal system process involved in regulation of systemic arterial blood pressureGO:000307110.015
negative regulation of kinase activityGO:003367340.015
intracellular signal transductionGO:0035556850.015
protein polyubiquitinationGO:000020940.015
muscle cell differentiationGO:00426921390.015
cellular respirationGO:004533330.015
negative regulation of sequence specific dna binding transcription factor activityGO:004343320.015
positive regulation of apoptotic signaling pathwayGO:200123510.015
regulation of cellular protein metabolic processGO:0032268520.015
cellular protein modification processGO:00064641000.015
Human
regulation of carbohydrate metabolic processGO:000610940.015
cell deathGO:00082191210.015
protein homooligomerizationGO:005126030.015
apoptotic processGO:00069151160.015
regulation of embryonic developmentGO:0045995470.015
regulation of reproductive processGO:200024140.015
regulation of wnt signaling pathwayGO:0030111530.015
cellular lipid catabolic processGO:004424230.015
gastrulationGO:00073692080.015
small molecule catabolic processGO:004428230.015
negative regulation of signalingGO:0023057960.015
establishment of protein localization to plasma membraneGO:009000210.015
mitochondrion organizationGO:000700540.014
negative regulation of secretion by cellGO:190353120.014
cellular component disassemblyGO:002241110.014
regulation of growthGO:0040008420.014
protein modification processGO:00362111000.014
Human
regulation of dendrite morphogenesisGO:004881430.014
negative regulation of metabolic processGO:0009892860.014
response to nutrientGO:000758430.014
cellular response to unfolded proteinGO:003462020.014
regulation of nucleobase containing compound metabolic processGO:00192192500.014
Human
somatic muscle developmentGO:000752540.014
cell cycle g1 s phase transitionGO:004484310.014
endomembrane system organizationGO:0010256130.014
regulation of cellular phGO:003064110.014
response to glucocorticoidGO:005138410.014
regulation of mrna splicing via spliceosomeGO:004802430.014
regulation of cell projection assemblyGO:006049140.014
regulation of protein modification by small protein conjugation or removalGO:190332030.014
regulation of jak stat cascadeGO:004642530.014
mitotic dna damage checkpointGO:004477340.014
positive regulation of stem cell proliferationGO:200064810.014
gland developmentGO:00487321430.014
double strand break repairGO:000630230.014
vasculature developmentGO:00019442780.014
chordate embryonic developmentGO:00430092710.014
cytoskeleton organizationGO:0007010960.014
axon guidanceGO:0007411860.014
positive regulation of cellular amino acid metabolic processGO:004576400.014
lipid homeostasisGO:005508830.014
hematopoietic or lymphoid organ developmentGO:00485341910.014
regulation of peptidyl tyrosine phosphorylationGO:005073010.014
eye developmentGO:00016542770.014
membrane organizationGO:0061024210.014
rna localizationGO:000640340.014
nephron epithelium morphogenesisGO:007208810.014
tube morphogenesisGO:00352393490.014
striated muscle cell differentiationGO:00511461290.014
catabolic processGO:0009056320.014
activation of mapk activityGO:000018730.014
neurotransmitter secretionGO:000726920.014
response to topologically incorrect proteinGO:003596620.013
regulation of protein metabolic processGO:0051246560.013
regulation of muscle hypertrophyGO:001474320.013
cellular response to hormone stimulusGO:0032870390.013
germ line stem cell maintenanceGO:003071820.013
organic substance catabolic processGO:1901575280.013
spermatid developmentGO:000728620.013
primary neural tube formationGO:001402010.013
mitotic dna integrity checkpointGO:004477440.013
multi organism cellular processGO:004476420.013
regulation of cell activationGO:005086510.013
regulation of proteolysisGO:0030162240.013
cell surface receptor signaling pathwayGO:00071663250.013
pancreas developmentGO:0031016840.013
regulation of tube sizeGO:003515020.013
negative regulation of signal transductionGO:0009968940.013
regulation of neuron projection developmentGO:0010975400.013
transmembrane receptor protein tyrosine kinase signaling pathwayGO:0007169420.013
epithelial tube morphogenesisGO:00605621480.013
developmental growth involved in morphogenesisGO:0060560860.013
cell substrate adhesionGO:003158940.013
epithelial cell morphogenesisGO:000338220.013
regulation of intracellular protein transportGO:003315730.013
neuromuscular synaptic transmissionGO:000727420.013
neuron projection guidanceGO:0097485860.013
nucleoside monophosphate catabolic processGO:000912540.013
positive regulation of cell adhesionGO:004578510.013
tube closureGO:006060610.013
positive regulation of translationGO:004572710.013
lateral inhibitionGO:004633110.013
actin filament based processGO:0030029640.012
liver developmentGO:0001889960.012
leukocyte proliferationGO:007066110.012
regulation of neuron differentiationGO:0045664560.012
cell fate commitmentGO:0045165990.012
protein stabilizationGO:005082120.012
regulation of neural precursor cell proliferationGO:200017730.012
regulation of molecular functionGO:0065009700.012
single fertilizationGO:000733830.012
mononuclear cell proliferationGO:003294310.012
glial cell migrationGO:000834730.012
carbohydrate homeostasisGO:003350010.012
cell projection assemblyGO:0030031640.012
regulation of receptor mediated endocytosisGO:004825940.012
g1 s transition of mitotic cell cycleGO:000008210.012
cell matrix adhesionGO:000716040.012
behaviorGO:0007610740.012
cellular amide metabolic processGO:004360340.012
organic acid catabolic processGO:001605430.012
retina development in camera type eyeGO:00600411460.012
internal protein amino acid acetylationGO:000647520.012
negative regulation of nitrogen compound metabolic processGO:0051172590.012
protein polymerizationGO:005125840.012
synaptic vesicle recyclingGO:003646510.012
embryo development ending in birth or egg hatchingGO:00097922710.012
regulation of protein ubiquitinationGO:003139630.012
regulation of protein localization to nucleusGO:190018020.012
regulation of transmembrane transporter activityGO:002289820.012
macroautophagyGO:001623610.012
cellular component assembly involved in morphogenesisGO:00109271070.012
convergent extension involved in gastrulationGO:0060027710.012
ribonucleoside monophosphate catabolic processGO:000915840.012
convergent extensionGO:00600261180.012
somite developmentGO:0061053960.012
purine nucleoside monophosphate catabolic processGO:000912840.012
negative regulation of mitosisGO:004583930.012
peptide transportGO:001583310.012
regulation of axonogenesisGO:0050770320.012
peptidyl lysine acetylationGO:001839420.012
cellular response to molecule of bacterial originGO:007121930.012
protein ubiquitination involved in ubiquitin dependent protein catabolic processGO:004278710.012
regulation of protein targetingGO:190353320.012
positive regulation of nucleobase containing compound metabolic processGO:0045935690.012
regulation of cell motilityGO:2000145460.011
regulation of protein polymerizationGO:003227120.011
negative regulation of response to stimulusGO:00485851040.011
carboxylic acid catabolic processGO:004639530.011
regulation of cell differentiationGO:00455951420.011
regulation of cell morphogenesis involved in differentiationGO:0010769380.011
regulation of neurotransmitter transportGO:005158810.011
negative regulation of rna splicingGO:003311910.011
retina morphogenesis in camera type eyeGO:0060042790.011
glucose homeostasisGO:004259310.011
regulation of phosphate metabolic processGO:0019220430.011
cellular response to organic substanceGO:00713101050.011
negative regulation of nuclear divisionGO:005178430.011
development of primary female sexual characteristicsGO:004654540.011
endocrine processGO:005088620.011
renal tubule morphogenesisGO:006133310.011
regenerationGO:0031099910.011
mitotic cell cycleGO:0000278640.011
negative regulation of cellular catabolic processGO:003133030.011
developmental programmed cell deathGO:001062340.011
symbiosis encompassing mutualism through parasitismGO:004440340.011
negative regulation of wnt signaling pathwayGO:0030178300.011
regulation of circadian rhythmGO:004275240.011
positive regulation of cell activationGO:005086710.011
b cell activationGO:004211320.011
double strand break repair via homologous recombinationGO:000072410.011
lymphocyte proliferationGO:004665110.011
response to ketoneGO:190165410.011
camera type eye developmentGO:00430102220.011
regulation of growth rateGO:004000910.011
compound eye developmentGO:004874920.011
regulation of extrinsic apoptotic signaling pathwayGO:200123630.011
proteolysisGO:0006508380.011
energy reserve metabolic processGO:000611220.011
circulatory system processGO:0003013870.011
golgi organizationGO:000703010.011
positive regulation of reproductive processGO:200024320.011
mechanosensory behaviorGO:000763820.011
regulation of microtubule cytoskeleton organizationGO:007050730.011
regulation of programmed cell deathGO:00430671010.011

ctdsp1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.034
disease of metabolismDOID:001466700.025
inherited metabolic disorderDOID:65500.021
nervous system diseaseDOID:86300.014
disease of cellular proliferationDOID:1456600.014
cancerDOID:16200.014
organ system cancerDOID:005068600.014
immune system diseaseDOID:291400.012
musculoskeletal system diseaseDOID:1700.012