Danio rerio

19 known processes

perp

PERP, TP53 apoptosis effector

(Aliases: wu:fk24g11)

perp biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
keratinocyte differentiationGO:003021600.683
tube morphogenesisGO:00352393490.665
single organism localizationGO:19025782250.516
cytoskeleton organizationGO:0007010960.361
immune system processGO:00023762410.314
Worm
cellular component morphogenesisGO:00329893360.279
nitrogen compound metabolic processGO:00068073190.258
response to chemicalGO:00422213200.250
ion transportGO:00068111140.249
desmosome assemblyGO:000215920.247
hemopoiesisGO:00300971830.246
single organism transportGO:00447652060.245
cortical cytoskeleton organizationGO:003086510.236
hematopoietic or lymphoid organ developmentGO:00485341910.211
regulation of developmental processGO:00507932470.204
regulation of water loss via skinGO:003356110.197
regulation of cell differentiationGO:00455951420.196
cellular macromolecule metabolic processGO:00442603910.187
Human
regulation of multicellular organismal developmentGO:20000262230.184
ectoderm developmentGO:000739890.181
regulation of neuron differentiationGO:0045664560.180
organelle organizationGO:00069962270.174
ectodermal cell fate specificationGO:000171520.168
regulation of biological qualityGO:00650082630.166
regulation of multicellular organismal processGO:00512392770.162
convergent extensionGO:00600261180.162
intestinal absorptionGO:005089220.160
myofibril assemblyGO:0030239480.160
long chain fatty acid transportGO:001590910.154
anterior posterior pattern specificationGO:00099521520.151
single organism organelle organizationGO:19025891990.146
biosynthetic processGO:00090582940.145
adherens junction organizationGO:003433240.139
cell fate specificationGO:0001708680.139
gene expressionGO:00104672520.138
Human
positive regulation of transportGO:005105020.137
cardiac conductionGO:006133730.136
cellular aromatic compound metabolic processGO:00067252950.128
digestive system developmentGO:00551232890.128
epidermis developmentGO:0008544480.127
cellular component movementGO:00069283350.126
cell motilityGO:00488702440.123
gastrulationGO:00073692080.122
cellular carbohydrate metabolic processGO:004426240.119
cellular macromolecule biosynthetic processGO:00346452240.118
response to abiotic stimulusGO:00096281220.116
developmental growthGO:00485891660.116
anterior head developmentGO:009706520.116
cellular nitrogen compound biosynthetic processGO:00442712180.115
regulation of neurogenesisGO:0050767870.113
positive regulation of canonical wnt signaling pathwayGO:009026340.112
striated muscle cell differentiationGO:00511461290.109
cognitionGO:005089010.106
multi organism processGO:00517041340.105
Worm
establishment of localizationGO:00512342440.105
response to stressGO:00069502630.105
Worm
positive regulation of nucleoside metabolic processGO:004597910.103
locomotionGO:00400113130.103
larval developmentGO:000216420.101
cellular localizationGO:0051641970.100
erythrocyte differentiationGO:0030218540.098
skin developmentGO:0043588540.097
actin mediated cell contractionGO:007025210.096
apoptotic processGO:00069151160.094
heterocycle biosynthetic processGO:00181302150.092
water homeostasisGO:003010440.092
immune system developmentGO:00025201910.091
response to other organismGO:0051707970.091
Worm
ectoderm formationGO:000170520.090
cell morphogenesis involved in differentiationGO:00009041950.089
epithelial tube morphogenesisGO:00605621480.087
carbohydrate derivative biosynthetic processGO:1901137430.087
regulation of localizationGO:00328791040.087
response to inorganic substanceGO:0010035380.086
regionalizationGO:00030022740.085
cellular component biogenesisGO:00440851780.084
hepaticobiliary system developmentGO:0061008980.083
wound healingGO:0042060900.080
growthGO:00400071740.080
homeostatic processGO:00425921420.079
regulation of ectodermal cell fate specificationGO:004266520.079
agingGO:000756820.078
neuroblast differentiationGO:001401610.077
myeloid cell homeostasisGO:0002262560.075
cell projection morphogenesisGO:00488582440.074
regulation of actin filament based movementGO:190311510.073
localization of cellGO:00516742440.073
response to external stimulusGO:00096052640.072
Worm
positive regulation of catabolic processGO:000989640.071
hatchingGO:003518840.071
organic substance biosynthetic processGO:19015762890.070
positive regulation of nucleobase containing compound metabolic processGO:0045935690.070
establishment of spindle localizationGO:0051293120.070
regenerationGO:0031099910.069
regulation of metabolic processGO:00192223590.069
Human
protein localization to membraneGO:007265790.069
desmosome organizationGO:000293430.068
Mouse
negative regulation of sequence specific dna binding transcription factor activityGO:004343320.067
actomyosin structure organizationGO:0031032530.066
regulation of anatomical structure morphogenesisGO:00226031300.066
notochord developmentGO:0030903540.066
plasma membrane repairGO:000177820.065
membrane invaginationGO:001032410.064
cellular response to starvationGO:000926710.064
stem cell proliferationGO:007208940.064
head developmentGO:00603223030.063
central nervous system developmentGO:00074173870.062
cell adhesionGO:0007155400.062
Mouse Worm
response to corticosteroidGO:003196010.061
response to external biotic stimulusGO:0043207970.060
Worm
muscle cell developmentGO:00550011150.060
protein localizationGO:0008104400.060
guanosine containing compound metabolic processGO:190106840.058
specification of axis polarityGO:006500140.058
cell migration involved in gastrulationGO:0042074790.057
cellular response to external stimulusGO:007149620.057
fin regenerationGO:0031101510.057
cell projection organizationGO:00300302840.056
digestive tract developmentGO:00485652650.056
convergent extension involved in gastrulationGO:0060027710.056
dorsal convergenceGO:0060030140.055
cellular nitrogen compound metabolic processGO:00346412900.054
system processGO:00030081850.054
regulation of response to stimulusGO:00485832690.054
lateral line system developmentGO:0048925760.054
skeletal system morphogenesisGO:00487051020.054
cell surface receptor signaling pathwayGO:00071663250.053
response to metal ionGO:0010038340.053
negative regulation of cellular processGO:00485232830.052
regulation of cell developmentGO:00602841000.052
developmental growth involved in morphogenesisGO:0060560860.052
actin cytoskeleton organizationGO:0030036630.051
regulation of cellular biosynthetic processGO:00313262450.051
regulation of synaptic plasticityGO:004816710.051
stem cell maintenanceGO:001982740.050
positive regulation of gtpase activityGO:004354710.050
response to biotic stimulusGO:0009607970.050
Worm
cortical actin cytoskeleton organizationGO:003086610.049
tissue regenerationGO:0042246740.049
organism emergence from protective structureGO:007168440.049
odontogenesis of dentin containing toothGO:004247510.049
Mouse
digestive tract morphogenesisGO:00485462310.049
regulation of primary metabolic processGO:00800903110.048
Human
striated muscle cell developmentGO:00550021080.048
cellular response to chemical stimulusGO:00708871570.048
heart loopingGO:0001947940.048
cellular response to extracellular stimulusGO:003166820.048
sensory organ developmentGO:00074233930.048
fin morphogenesisGO:0033334530.047
cell deathGO:00082191210.047
regulation of locomotionGO:0040012550.047
lipid digestionGO:004424130.046
immune responseGO:0006955280.046
Worm
epithelial cell differentiationGO:00308551160.046
regulation of eye photoreceptor cell developmentGO:004247820.046
regulation of actin filament based processGO:003297090.046
phagocytosisGO:000690930.045
actin filament based movementGO:003004810.045
regulation of epidermis developmentGO:004568220.045
cellular component assemblyGO:00226071700.045
cell growthGO:0016049570.045
regulation of photoreceptor cell differentiationGO:004653220.043
response to woundingGO:00096111160.043
cardiac muscle cell contractionGO:008600310.043
macromolecule biosynthetic processGO:00090592270.043
response to glucocorticoidGO:005138410.043
chordate embryonic developmentGO:00430092710.042
muscle structure developmentGO:00610611960.042
sensory system developmentGO:0048880760.042
establishment of protein localization to organelleGO:007259440.042
fin developmentGO:0033333770.041
regulation of gtp catabolic processGO:003312420.041
small gtpase mediated signal transductionGO:000726480.040
response to organic cyclic compoundGO:0014070510.040
regulation of protein ubiquitinationGO:003139630.040
regulation of cardiac muscle cell contractionGO:008600410.040
cell junction organizationGO:0034330110.040
Mouse
organelle assemblyGO:00709251100.040
cellular biosynthetic processGO:00442492860.039
organic substance transportGO:0071702580.038
negative regulation of mitosisGO:004583930.038
cardiac conduction system developmentGO:000316110.038
heart developmentGO:00075073130.038
protein metabolic processGO:00195381830.038
Human
membrane organizationGO:0061024210.038
regulation of cytokine productionGO:000181730.037
intestinal cholesterol absorptionGO:003029920.037
cardiocyte differentiationGO:0035051440.037
phagocytosis engulfmentGO:000691110.037
establishment of endothelial barrierGO:006102830.037
appendage developmentGO:0048736800.036
negative regulation of cell fate commitmentGO:0010454130.036
transportGO:00068102200.036
ameboidal type cell migrationGO:00016671430.036
positive regulation of gene expressionGO:0010628710.036
organonitrogen compound biosynthetic processGO:1901566470.036
actin filament based processGO:0030029640.036
gland developmentGO:00487321430.036
positive regulation of purine nucleotide catabolic processGO:003312310.036
cation transportGO:0006812810.036
mitotic cell cycle embryonicGO:004544820.035
microtubule cytoskeleton organizationGO:0000226330.035
signal transductionGO:00071654550.035
Mouse
negative regulation of nuclear divisionGO:005178430.035
gastrulation with mouth forming secondGO:0001702440.035
regulation of epithelial cell proliferationGO:005067830.035
establishment or maintenance of epithelial cell apical basal polarityGO:0045197110.035
cell part morphogenesisGO:00329902460.034
action potentialGO:0001508190.034
organic cyclic compound metabolic processGO:19013603010.034
generation of neuronsGO:00486993850.034
aromatic compound biosynthetic processGO:00194382170.034
positive regulation of neuron apoptotic processGO:004352510.034
hepatocyte proliferationGO:007257420.034
positive regulation of cell deathGO:0010942290.034
embryo development ending in birth or egg hatchingGO:00097922710.033
protein complex subunit organizationGO:0071822460.033
regulation of gene expressionGO:00104682650.033
cell proliferationGO:0008283800.033
stem cell developmentGO:0048864820.033
circulatory system processGO:0003013870.033
regulation of multicellular organism growthGO:004001440.033
melanin metabolic processGO:000658220.032
positive regulation of cellular catabolic processGO:003133130.032
response to uvGO:000941130.032
macromolecule localizationGO:0033036540.032
regulation of immune responseGO:0050776140.032
nucleic acid metabolic processGO:00903042440.032
microtubule based processGO:0007017600.032
regulation of wnt signaling pathway involved in heart developmentGO:000330720.032
embryonic skeletal joint morphogenesisGO:006027230.031
regulation of circadian rhythmGO:004275240.031
response to transition metal nanoparticleGO:1990267280.031
regulation of biosynthetic processGO:00098892500.031
epithelial cell developmentGO:0002064420.031
response to nutrientGO:000758430.030
neutrophil homeostasisGO:000178010.030
negative regulation of epithelial cell proliferationGO:005068010.030
golgi vesicle transportGO:004819330.030
regulation of system processGO:0044057400.030
regulation of erk1 and erk2 cascadeGO:007037240.030
positive regulation of ras protein signal transductionGO:004657910.030
regulation of phosphate metabolic processGO:0019220430.030
ras protein signal transductionGO:000726570.030
digestive system processGO:002260090.030
vasculature developmentGO:00019442780.029
protein targeting to nucleusGO:004474430.029
negative regulation of wnt signaling pathway involved in heart developmentGO:000330820.029
defense responseGO:0006952470.029
Worm
positive regulation of transcription from rna polymerase ii promoterGO:0045944220.029
liver developmentGO:0001889960.028
cellular response to nutrient levelsGO:003166920.028
neuron projection morphogenesisGO:00488121610.028
cell cell adhesion involved in mesendodermal cell migrationGO:000337010.028
regulation of cell communicationGO:00106462320.028
multicellular organism growthGO:003526440.028
regulation of establishment of protein localizationGO:007020140.028
positive regulation of gtp catabolic processGO:003312610.027
nucleic acid templated transcriptionGO:00976591810.027
regulation of muscle contractionGO:000693730.027
myeloid cell differentiationGO:0030099860.027
regulation of nucleobase containing compound metabolic processGO:00192192500.027
ectodermal cell differentiationGO:001066820.026
regulation of nucleotide catabolic processGO:003081120.026
regulation of autophagyGO:001050630.026
positive regulation of nitrogen compound metabolic processGO:0051173690.026
spindle localizationGO:0051653120.026
regulation of transcription dna templatedGO:00063552130.026
multicellular organismal water homeostasisGO:005089110.026
positive regulation of hydrolase activityGO:0051345130.026
Human
regulation of response to stressGO:0080134360.026
apical junction assemblyGO:004329710.026
establishment of cell polarityGO:0030010180.026
positive regulation of nucleotide catabolic processGO:003081310.026
protein import into nucleusGO:000660630.025
regulation of macromolecule biosynthetic processGO:00105562250.025
cellular component disassemblyGO:002241110.025
carbohydrate derivative metabolic processGO:1901135610.025
regulation of organ morphogenesisGO:2000027350.025
regulation of rna biosynthetic processGO:20011412130.025
ectodermal cell fate commitmentGO:000171220.025
negative regulation of cytokine productionGO:000181810.024
meiotic nuclear divisionGO:000712640.024
cardioblast differentiationGO:001000290.024
regulation of nucleoside metabolic processGO:000911820.024
negative regulation of multicellular organismal processGO:0051241690.024
cardiac cell developmentGO:0055006210.024
establishment of cell polarity involved in gastrulation cell migrationGO:000337920.024
determination of left right symmetryGO:00073681790.023
regulation of cellular component movementGO:0051270550.023
axon developmentGO:00615641660.023
positive regulation of cellular processGO:00485222010.023
Human
response to steroid hormoneGO:0048545350.023
transcription from rna polymerase ii promoterGO:0006366800.023
determination of bilateral symmetryGO:00098552040.022
meiotic chromosome segregationGO:004513230.022
regulation of anterior head developmentGO:200074220.022
positive regulation of multicellular organismal processGO:0051240520.022
neural crest cell developmentGO:0014032620.022
protein secretionGO:000930610.022
gtp catabolic processGO:000618420.022
establishment of monopolar cell polarityGO:006116220.022
epibolyGO:0090504410.022
rna metabolic processGO:00160702190.022
regulation of protein transportGO:005122330.022
positive regulation of apoptotic processGO:0043065290.022
establishment of mitotic spindle orientationGO:0000132100.022
positive regulation of rna metabolic processGO:0051254590.022
cellular component assembly involved in morphogenesisGO:00109271070.022
positive regulation of i kappab kinase nf kappab signalingGO:004312330.022
positive regulation of cytoskeleton organizationGO:005149530.022
negative regulation of cell fate specificationGO:0009996110.022
morphogenesis of an epitheliumGO:00020093330.022
neurological system processGO:0050877620.021
cell migration involved in mesendoderm migrationGO:009013420.021
skeletal system developmentGO:00015011810.021
regulation of stem cell differentiationGO:200073640.021
cell morphogenesisGO:00009022890.021
negative regulation of kinase activityGO:003367340.021
protein importGO:001703830.021
protein localization to plasma membraneGO:007265910.021
axis elongation involved in somitogenesisGO:009024520.021
negative regulation of defense responseGO:003134820.021
cell fate commitmentGO:0045165990.021
blood vessel developmentGO:00015682460.021
extrinsic apoptotic signaling pathwayGO:009719130.021
regulation of ectoderm developmentGO:200038320.020
muscle cell differentiationGO:00426921390.020
nucleobase containing compound metabolic processGO:00061392740.020
regulation of wound healingGO:006104120.020
adherens junction maintenanceGO:003433420.020
meiotic cell cycle processGO:190304630.020
establishment of mitotic spindle localizationGO:0040001120.020
energy reserve metabolic processGO:000611220.020
heterocycle metabolic processGO:00464832900.020
regulation of wnt signaling pathway involved in digestive tract morphogenesisGO:200005620.020
cell migrationGO:00164772370.020
cellular response to organic substanceGO:00713101050.019
regulation of rna metabolic processGO:00512522240.019
single organism cellular localizationGO:1902580460.019
oogenesisGO:0048477140.019
cellular response to oxygen levelsGO:007145310.019
positive regulation of cell activationGO:005086710.019
spermatid differentiationGO:004851520.019
ear developmentGO:00435831270.019
endomembrane system organizationGO:0010256130.019
cellular response to radiationGO:007147840.019
cell agingGO:000756920.019
single organism nuclear importGO:190259330.018
negative regulation of response to stimulusGO:00485851040.018
establishment of localization in cellGO:0051649770.018
gamete generationGO:0007276330.018
establishment or maintenance of cell polarityGO:0007163290.018
epithelial cell proliferation involved in liver morphogenesisGO:007257520.018
cellular protein localizationGO:0034613200.018
reactive oxygen species metabolic processGO:007259360.018
embryonic heart tube developmentGO:00350501330.018
mesodermal cell fate commitmentGO:0001710140.018
organic cyclic compound biosynthetic processGO:19013622230.018
protein complex assemblyGO:0006461300.018
nitric oxide metabolic processGO:004620920.018
embryonic skeletal system developmentGO:0048706970.018
organelle localizationGO:0051640490.018
programmed cell deathGO:00125011190.018
regulation of microtubule cytoskeleton organizationGO:007050730.017
regulation of membrane potentialGO:0042391230.017
cell cell signalingGO:0007267520.017
peptidyl serine phosphorylationGO:001810510.017
negative regulation of cell differentiationGO:0045596460.017
regulation of cellular macromolecule biosynthetic processGO:20001122220.017
regulation of nucleic acid templated transcriptionGO:19035062130.017
gtp metabolic processGO:004603940.017
regulation of cell deathGO:00109411030.017
calcium dependent cell cell adhesion via plasma membrane cell adhesion moleculesGO:001633920.017
retina development in camera type eyeGO:00600411460.017
response to bacteriumGO:0009617580.017
Worm
regulation of striated muscle contractionGO:000694220.017
inner ear receptor stereocilium organizationGO:006012280.017
negative regulation of protein transportGO:005122430.017
multicellular organism reproductionGO:0032504350.017
positive regulation of macromolecule biosynthetic processGO:0010557590.017
single organism metabolic processGO:00447102170.016
deathGO:00162651210.016
establishment of protein localization to plasma membraneGO:009000210.016
negative regulation of cell communicationGO:0010648960.016
regulation of response to cytokine stimulusGO:006075930.016
regulation of nervous system developmentGO:0051960900.016
cell cell adhesion involved in gastrulationGO:007058640.016
negative regulation of autophagyGO:001050710.016
erk1 and erk2 cascadeGO:007037140.016
compound eye developmentGO:004874920.016
regulation of catalytic activityGO:0050790550.016
Human
positive regulation of rna biosynthetic processGO:1902680570.016
reproductionGO:0000003400.016
cell cycleGO:0007049930.016
synaptic transmissionGO:0007268350.016
extrinsic apoptotic signaling pathway in absence of ligandGO:009719210.016
regulation of cellular component organizationGO:0051128860.016
cell type specific apoptotic processGO:0097285220.016
tissue remodelingGO:004877140.016
determination of dorsal ventral asymmetryGO:0048262340.016
brain developmentGO:00074202930.016
negative regulation of apoptotic processGO:0043066550.016
regulation of cell motilityGO:2000145460.016
actin polymerization or depolymerizationGO:000815420.016
regulation of nitrogen compound metabolic processGO:00511712510.016
regulation of neuronal synaptic plasticityGO:004816810.016
regulation of purine nucleotide catabolic processGO:003312120.016
amine metabolic processGO:000930820.016
regulation of macromolecule metabolic processGO:00602553170.016
Human
multi organism reproductive processGO:0044703360.016
organonitrogen compound metabolic processGO:1901564740.016
developmental programmed cell deathGO:001062340.015
positive regulation of cellular biosynthetic processGO:0031328680.015
nerve developmentGO:0021675450.015
cell fate commitment involved in formation of primary germ layerGO:0060795260.015
wnt signaling pathwayGO:0016055800.015
pigment cell developmentGO:007028530.015
regulation of anatomical structure sizeGO:0090066330.015
kupffer s vesicle developmentGO:0070121500.015
proximal distal pattern formationGO:000995410.015
negative regulation of secretion by cellGO:190353120.015
regulation of protein import into nucleusGO:004230620.015
wnt signaling pathway planar cell polarity pathwayGO:006007140.015
cell morphogenesis involved in neuron differentiationGO:00486671630.015
negative regulation of stem cell differentiationGO:200073720.015
negative regulation of protein phosphorylationGO:000193340.015
maintenance of locationGO:005123540.015
response to light stimulusGO:0009416460.015
homeostasis of number of cellsGO:0048872620.015
atrioventricular valve developmentGO:0003171110.015
zymogen activationGO:003163830.015
Human
single organism cell adhesionGO:0098602290.015
Mouse Worm
negative regulation of i kappab kinase nf kappab signalingGO:004312410.015
dorsal ventral pattern formationGO:00099531250.015
mesendoderm migrationGO:009013320.015
regulation of ras gtpase activityGO:003231820.015
reproductive processGO:0022414400.015
positive regulation of small gtpase mediated signal transductionGO:005105710.014
positive regulation of purine nucleotide metabolic processGO:190054490.014
protein polymerizationGO:005125840.014
specification of symmetryGO:00097992040.014
hematopoietic stem cell migrationGO:003570140.014
regulation of neuron migrationGO:200122220.014
macroautophagyGO:001623610.014
regulation of response to external stimulusGO:0032101310.014
circadian rhythmGO:0007623190.014
retina morphogenesis in camera type eyeGO:0060042790.014
epiboly involved in gastrulation with mouth forming secondGO:0055113350.014
tissue migrationGO:0090130370.014
regulation of apoptotic processGO:0042981980.014
sprouting angiogenesisGO:0002040530.014
regulation of protein catabolic processGO:004217610.014
regulation of synapse assemblyGO:005196330.014
macromolecule modificationGO:00434121110.014
inner ear developmentGO:00488391260.014
positive regulation of biological processGO:00485182530.014
Human
regulation of programmed cell deathGO:00430671010.013
secondary metabolic processGO:001974830.013
cellular response to decreased oxygen levelsGO:003629410.013
nucleobase containing compound biosynthetic processGO:00346542050.013
phosphorylationGO:0016310690.013
regulation of intracellular protein transportGO:003315730.013
apoptotic process involved in morphogenesisGO:006056120.013
regulation of cellular metabolic processGO:00313233200.013
Human
regulation of vesicle mediated transportGO:006062790.013
cardiac cell fate commitmentGO:006091110.013
establishment of cell polarity involved in ameboidal cell migrationGO:000336520.013
positive regulation of cellular metabolic processGO:0031325940.013
Human
rna biosynthetic processGO:00327741810.013
somite developmentGO:0061053960.013
establishment of spindle orientationGO:0051294100.013
regulation of organ growthGO:004662030.013
regulation of transportGO:0051049450.013
regulation of blood circulationGO:1903522320.013
negative regulation of mesodermal cell fate specificationGO:004266230.013
regulation of developmental growthGO:0048638380.013
regulation of response to biotic stimulusGO:000283120.013
regulation of cellular component sizeGO:0032535300.013
establishment of apical basal cell polarityGO:003508920.013
endocardial cushion formationGO:000327220.013
phosphate containing compound metabolic processGO:00067961080.013
post golgi vesicle mediated transportGO:000689210.013
negative regulation of mesoderm developmentGO:200038150.013

perp disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
muscle tissue diseaseDOID:6600.132
cardiovascular system diseaseDOID:128700.132
muscular diseaseDOID:008000000.132
myopathyDOID:42300.132
disease of anatomical entityDOID:700.132
musculoskeletal system diseaseDOID:1700.132
cardiomyopathyDOID:005070000.132
heart diseaseDOID:11400.132
intrinsic cardiomyopathyDOID:006003600.112
disease of cellular proliferationDOID:1456600.070
thoracic cancerDOID:509300.070
cancerDOID:16200.070
organ system cancerDOID:005068600.070
integumentary system diseaseDOID:1600.049
breast cancerDOID:161200.026