Danio rerio

0 known processes

comtb

catechol-O-methyltransferase b

(Aliases: zK13A21.15,zgc:162236,si:dkey-13a21.15)

comtb biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
larval developmentGO:000216420.085
positive regulation of transportGO:005105020.066
response to chemicalGO:00422213200.057
positive regulation of cellular component biogenesisGO:004408930.056
cognitionGO:005089010.052
single organism transportGO:00447652060.051
agingGO:000756820.050
signal transductionGO:00071654550.049
neuron developmentGO:00486662620.046
maintenance of locationGO:005123540.044
synaptic growth at neuromuscular junctionGO:005112420.043
regulation of biological qualityGO:00650082630.043
regulation of protein complex assemblyGO:004325430.042
small molecule metabolic processGO:0044281770.041
positive regulation of cellular catabolic processGO:003133130.039
multicellular organism growthGO:003526440.039
establishment of localizationGO:00512342440.039
central nervous system developmentGO:00074173870.039
cellular response to external stimulusGO:007149620.038
response to drugGO:004249330.038
regulation of signalingGO:00230512350.037
transportGO:00068102200.037
regulation of autophagyGO:001050630.037
transmembrane transportGO:00550851200.037
cellular biosynthetic processGO:00442492860.037
regulation of synapse assemblyGO:005196330.035
cell morphogenesisGO:00009022890.035
autophagyGO:000691440.034
adult behaviorGO:003053420.034
cell surface receptor signaling pathwayGO:00071663250.034
negative regulation of biological processGO:00485193040.034
neurotransmitter transportGO:000683620.034
phagocytosisGO:000690930.033
cellular carbohydrate metabolic processGO:004426240.032
regulation of synaptic growth at neuromuscular junctionGO:000858210.032
g protein coupled receptor signaling pathwayGO:0007186740.032
cellular nitrogen compound metabolic processGO:00346412900.031
negative regulation of cellular processGO:00485232830.031
single organism localizationGO:19025782250.031
nitrogen compound metabolic processGO:00068073190.031
regulation of metabolic processGO:00192223590.030
cellular response to extracellular stimulusGO:003166820.030
response to stressGO:00069502630.030
generation of neuronsGO:00486993850.030
protein polymerizationGO:005125840.029
actin polymerization or depolymerizationGO:000815420.029
single organism metabolic processGO:00447102170.029
carboxylic acid metabolic processGO:0019752220.029
neuron differentiationGO:00301823530.029
biosynthetic processGO:00090582940.029
establishment of protein localization to organelleGO:007259440.028
regulation of synapse organizationGO:005080730.028
response to carbohydrateGO:000974330.028
organic cyclic compound metabolic processGO:19013603010.028
negative regulation of protein phosphorylationGO:000193340.028
positive regulation of catabolic processGO:000989640.028
organonitrogen compound metabolic processGO:1901564740.028
response to external stimulusGO:00096052640.027
gtp metabolic processGO:004603940.027
regulation of multicellular organismal developmentGO:20000262230.027
regulation of cellular metabolic processGO:00313233200.027
cellular response to nutrient levelsGO:003166920.027
cellular aromatic compound metabolic processGO:00067252950.027
cellular component morphogenesisGO:00329893360.027
guanosine containing compound metabolic processGO:190106840.027
macromolecular complex disassemblyGO:003298410.027
organic substance biosynthetic processGO:19015762890.026
regulation of circadian rhythmGO:004275240.026
head developmentGO:00603223030.026
regulation of multicellular organism growthGO:004001440.026
gtp catabolic processGO:000618420.026
lipid storageGO:001991510.026
protein localization to nucleusGO:003450430.026
regulation of nitrogen compound metabolic processGO:00511712510.026
exocytosisGO:000688710.026
cellular response to starvationGO:000926710.026
neuron neuron synaptic transmissionGO:000727010.026
embryonic organ developmentGO:00485683810.026
cellular macromolecule metabolic processGO:00442603910.025
brain developmentGO:00074202930.025
cellular response to chemical stimulusGO:00708871570.025
response to monosaccharideGO:003428430.025
regulation of primary metabolic processGO:00800903110.025
regulation of blood vessel sizeGO:005088020.025
cellular component biogenesisGO:00440851780.025
guanosine containing compound catabolic processGO:190106920.025
positive regulation of cell cycleGO:004578730.025
regulation of signal transductionGO:00099662250.025
regulation of protein catabolic processGO:004217610.025
cell morphogenesis involved in neuron differentiationGO:00486671630.025
amine metabolic processGO:000930820.024
morphogenesis of an epitheliumGO:00020093330.024
positive regulation of biological processGO:00485182530.024
cellular component assemblyGO:00226071700.024
regulation of cytokine productionGO:000181730.024
regulation of tube sizeGO:003515020.024
regulation of establishment of protein localizationGO:007020140.024
cellular component disassemblyGO:002241110.024
heterocycle metabolic processGO:00464832900.024
regulation of developmental processGO:00507932470.023
single organism membrane fusionGO:004480120.023
stem cell proliferationGO:007208940.023
regulation of response to stimulusGO:00485832690.023
energy reserve metabolic processGO:000611220.023
organelle fusionGO:004828430.023
protein importGO:001703830.023
membrane fusionGO:006102520.023
cell part morphogenesisGO:00329902460.022
regulation of cellular carbohydrate metabolic processGO:001067540.022
regulation of cell communicationGO:00106462320.022
protein complex disassemblyGO:004324110.022
cellular ketone metabolic processGO:0042180110.022
cellular nitrogen compound biosynthetic processGO:00442712180.022
regulation of multicellular organismal processGO:00512392770.022
heart developmentGO:00075073130.022
regulation of cellular amino acid metabolic processGO:000652100.022
ion transmembrane transportGO:0034220910.022
single organism organelle organizationGO:19025891990.022
regulation of transmembrane transporter activityGO:002289820.022
cell projection morphogenesisGO:00488582440.021
cell projection organizationGO:00300302840.021
purine ribonucleoside monophosphate catabolic processGO:000916940.021
cytokinesisGO:000091030.021
system processGO:00030081850.021
cell substrate adhesionGO:003158940.021
nucleobase containing compound metabolic processGO:00061392740.021
neurotransmitter secretionGO:000726920.021
organic acid metabolic processGO:0006082310.021
regulation of protein polymerizationGO:003227120.021
cellular response to lipopolysaccharideGO:007122230.021
organelle organizationGO:00069962270.021
negative regulation of catabolic processGO:000989530.021
nucleobase containing compound biosynthetic processGO:00346542050.021
neuroblast proliferationGO:000740520.020
aromatic compound biosynthetic processGO:00194382170.020
regulation of protein transportGO:005122330.020
sensory perception of chemical stimulusGO:000760630.020
regulation of cellular ketone metabolic processGO:001056570.020
regulation of reproductive processGO:200024140.020
positive regulation of protein complex assemblyGO:003133420.020
female sex differentiationGO:004666040.020
female gonad developmentGO:000858540.020
leukocyte proliferationGO:007066110.020
lateral inhibitionGO:004633110.020
development of primary female sexual characteristicsGO:004654540.020
response to alkaloidGO:004327920.020
response to organic substanceGO:00100331530.020
regulation of i kappab kinase nf kappab signalingGO:004312240.020
neuron projection developmentGO:00311751800.020
response to hexoseGO:000974630.020
eye developmentGO:00016542770.020
amino acid transportGO:000686520.020
regulation of metal ion transportGO:001095940.020
growthGO:00400071740.020
nucleocytoplasmic transportGO:000691340.020
cellular component movementGO:00069283350.020
carbohydrate biosynthetic processGO:001605110.020
vasculature developmentGO:00019442780.019
camera type eye developmentGO:00430102220.019
chordate embryonic developmentGO:00430092710.019
cell migrationGO:00164772370.019
negative regulation of protein kinase activityGO:000646940.019
protein metabolic processGO:00195381830.019
nuclear transportGO:005116940.019
heterocycle biosynthetic processGO:00181302150.019
regulation of carbohydrate metabolic processGO:000610940.019
extrinsic apoptotic signaling pathwayGO:009719130.019
cell morphogenesis involved in differentiationGO:00009041950.019
fatty acid transportGO:001590810.019
regulation of cellular amine metabolic processGO:003323800.019
single organism nuclear importGO:190259330.019
ubiquitin dependent protein catabolic processGO:000651130.019
gene expressionGO:00104672520.019
cellular response to organic substanceGO:00713101050.019
i kappab kinase nf kappab signalingGO:000724940.019
regulation of macromolecule metabolic processGO:00602553170.018
cellular amine metabolic processGO:004410620.018
rna biosynthetic processGO:00327741810.018
regionalizationGO:00030022740.018
single organism biosynthetic processGO:0044711710.018
regulation of cell activationGO:005086510.018
synaptic vesicle transportGO:004848910.018
regulation of hormone secretionGO:004688320.018
homeostatic processGO:00425921420.018
negative regulation of kinase activityGO:003367340.018
response to glucoseGO:000974930.018
protein targeting to nucleusGO:004474430.018
regulation of synaptic plasticityGO:004816710.018
regulation of nucleoside metabolic processGO:000911820.018
protein localization to plasma membraneGO:007265910.018
regulation of cellular biosynthetic processGO:00313262450.018
lipid catabolic processGO:001604240.018
carboxylic acid catabolic processGO:004639530.018
muscle cell developmentGO:00550011150.018
nuclear importGO:005117030.018
regulation of extrinsic apoptotic signaling pathwayGO:200123630.017
developmental growthGO:00485891660.017
oxoacid metabolic processGO:0043436310.017
macromolecule biosynthetic processGO:00090592270.017
regulation of epithelial cell proliferationGO:005067830.017
embryo development ending in birth or egg hatchingGO:00097922710.017
actin filament polymerizationGO:003004120.017
response to corticosteroidGO:003196010.017
regulation of cell projection assemblyGO:006049140.017
regulation of cytoplasmic transportGO:190364940.017
proteasome mediated ubiquitin dependent protein catabolic processGO:004316120.017
proteolysis involved in cellular protein catabolic processGO:005160330.017
cellular amino acid metabolic processGO:000652070.017
phosphate containing compound metabolic processGO:00067961080.017
regulation of muscle contractionGO:000693730.017
hormone transportGO:000991420.017
adherens junction organizationGO:003433240.017
axonogenesisGO:00074091520.017
rna localizationGO:000640340.017
nucleoside monophosphate catabolic processGO:000912540.017
peptide transportGO:001583310.017
regulation of bindingGO:005109830.017
fluid transportGO:0042044170.017
cellular macromolecule biosynthetic processGO:00346452240.017
locomotionGO:00400113130.017
muscle structure developmentGO:00610611960.017
determination of bilateral symmetryGO:00098552040.017
regulation of cell shapeGO:000836010.017
rna metabolic processGO:00160702190.017
transcription dna templatedGO:00063511810.017
axon developmentGO:00615641660.017
ion transportGO:00068111140.017
hormone secretionGO:004687920.017
inorganic ion transmembrane transportGO:0098660570.017
mononuclear cell proliferationGO:003294310.017
regulation of filopodium assemblyGO:005148920.017
golgi vesicle transportGO:004819330.016
neuron projection morphogenesisGO:00488121610.016
protein import into nucleusGO:000660630.016
positive regulation of cytoskeleton organizationGO:005149530.016
modification dependent protein catabolic processGO:001994130.016
smooth muscle contractionGO:000693920.016
alcohol biosynthetic processGO:004616520.016
positive regulation of secretionGO:005104710.016
organic acid catabolic processGO:001605430.016
regulation of gene expressionGO:00104682650.016
cation transmembrane transportGO:0098655650.016
monovalent inorganic cation transportGO:0015672420.016
inositol lipid mediated signalingGO:004801720.016
digestive system developmentGO:00551232890.016
actin filament based movementGO:003004810.016
carbohydrate derivative metabolic processGO:1901135610.016
inorganic cation transmembrane transportGO:0098662500.016
intracellular signal transductionGO:0035556850.016
regulation of dendrite developmentGO:005077330.016
sensory organ developmentGO:00074233930.016
response to abiotic stimulusGO:00096281220.016
positive regulation of cellular processGO:00485222010.016
embryonic organ morphogenesisGO:00485622740.016
actin filament based processGO:0030029640.015
synaptic vesicle localizationGO:009747910.015
phosphorus metabolic processGO:00067931090.015
regulation of neurotransmitter secretionGO:004692810.015
blood vessel developmentGO:00015682460.015
small molecule catabolic processGO:004428230.015
establishment of synaptic vesicle localizationGO:009748010.015
regulation of protein localization to nucleusGO:190018020.015
carbon dioxide transportGO:001567030.015
modification dependent macromolecule catabolic processGO:004363230.015
digestive tract developmentGO:00485652650.015
immune system processGO:00023762410.015
carbohydrate homeostasisGO:003350010.015
stem cell maintenanceGO:001982740.015
response to nutrientGO:000758430.015
cytoplasm organizationGO:000702840.015
regulation of gtp catabolic processGO:003312420.015
tube morphogenesisGO:00352393490.015
ribonucleoside monophosphate catabolic processGO:000915840.015
regulation of peptidyl tyrosine phosphorylationGO:005073010.015
regulation of ion transmembrane transporter activityGO:003241220.015
regulation of transporter activityGO:003240920.015
positive regulation of secretion by cellGO:190353210.015
protein acylationGO:004354330.015
regulation of nervous system developmentGO:0051960900.015
regulation of glucose transportGO:001082710.015
membrane invaginationGO:001032410.015
regulation of neurogenesisGO:0050767870.015
glucose homeostasisGO:004259310.015
macroautophagyGO:001623610.015
lipid homeostasisGO:005508830.014
positive regulation of glucose importGO:004632610.014
phagocytosis engulfmentGO:000691110.014
regulation of purine nucleotide catabolic processGO:003312120.014
specification of symmetryGO:00097992040.014
regulation of nucleobase containing compound metabolic processGO:00192192500.014
signal transduction in absence of ligandGO:003803410.014
regulation of nucleocytoplasmic transportGO:004682220.014
positive regulation of purine nucleotide catabolic processGO:003312310.014
proteasomal protein catabolic processGO:001049820.014
endosomal transportGO:001619720.014
regulation of inflammatory responseGO:005072720.014
negative regulation of metabolic processGO:0009892860.014
lymphocyte proliferationGO:004665110.014
nucleic acid templated transcriptionGO:00976591810.014
cellular component assembly involved in morphogenesisGO:00109271070.014
water transportGO:0006833150.014
sequestering of metal ionGO:005123830.014
regulation of intracellular protein transportGO:003315730.014
angiogenesisGO:00015251580.014
organic cyclic compound biosynthetic processGO:19013622230.014
positive regulation of cellular amine metabolic processGO:003324000.014
mechanosensory behaviorGO:000763820.014
xenobiotic metabolic processGO:000680540.014
cell motilityGO:00488702440.014
chemosensory behaviorGO:000763510.014
regulation of cellular component organizationGO:0051128860.014
protein homooligomerizationGO:005126030.014
positive regulation of gtp catabolic processGO:003312610.014
muscle cell differentiationGO:00426921390.014
negative regulation of mapk cascadeGO:004340940.014
nucleic acid metabolic processGO:00903042440.014
positive regulation of cell activationGO:005086710.014
sodium ion transmembrane transportGO:0035725210.014
post embryonic organ developmentGO:004856940.014
positive regulation of nucleotide catabolic processGO:003081310.014
chemical homeostasisGO:0048878490.014
regulation of calcium ion transportGO:005192420.014
compound eye developmentGO:004874920.014
cell matrix adhesionGO:000716040.014
striated muscle cell developmentGO:00550021080.014
negative regulation of signalingGO:0023057960.013
positive regulation of nucleoside metabolic processGO:004597910.013
cortical cytoskeleton organizationGO:003086510.013
regulation of neuron differentiationGO:0045664560.013
apical junction assemblyGO:004329710.013
atp catabolic processGO:000620040.013
regulation of biosynthetic processGO:00098892500.013
g1 s transition of mitotic cell cycleGO:000008210.013
positive regulation of gtpase activityGO:004354710.013
regulation of gtpase activityGO:004308720.013
response to transition metal nanoparticleGO:1990267280.013
protein secretionGO:000930610.013
positive regulation of cytosolic calcium ion concentrationGO:000720440.013
cell cycle g1 s phase transitionGO:004484310.013
positive regulation of dna metabolic processGO:005105410.013
negative regulation of sequestering of calcium ionGO:005128340.013
negative regulation of synapse assemblyGO:005196420.013
localization of cellGO:00516742440.013
positive regulation of i kappab kinase nf kappab signalingGO:004312330.013
regulation of cellular macromolecule biosynthetic processGO:20001122220.013
response to endogenous stimulusGO:0009719830.013
regulation of protein targetingGO:190353320.013
enzyme linked receptor protein signaling pathwayGO:00071671060.013
regulation of apoptotic processGO:0042981980.013
phosphatidylinositol mediated signalingGO:004801520.013
striated muscle cell differentiationGO:00511461290.013
extrinsic apoptotic signaling pathway in absence of ligandGO:009719210.013
macromolecule modificationGO:00434121110.013
negative regulation of cellular catabolic processGO:003133030.012
hemopoiesisGO:00300971830.012
regulation of rna biosynthetic processGO:20011412130.012
regulation of protein complex disassemblyGO:004324410.012
multicellular organismal signalingGO:0035637220.012
regulation of anatomical structure morphogenesisGO:00226031300.012
negative regulation of autophagyGO:001050710.012
intracellular mrna localizationGO:000829810.012
skeletal muscle organ developmentGO:0060538780.012
positive regulation of cytokine productionGO:000181920.012
regulation of neural precursor cell proliferationGO:200017730.012
blood vessel morphogenesisGO:00485142160.012
gas transportGO:001566930.012
protein depolymerizationGO:005126110.012
cellular response to oxygen levelsGO:007145310.012
positive regulation of map kinase activityGO:004340630.012
regulation of protein depolymerizationGO:190187910.012
regulation of nucleic acid templated transcriptionGO:19035062130.012
sleepGO:003043110.012
regulation of macromolecule biosynthetic processGO:00105562250.012
sensory perception of painGO:001923310.012
cellular response to biotic stimulusGO:007121630.012
programmed cell deathGO:00125011190.012
regulation of response to extracellular stimulusGO:003210410.012
cellular response to radiationGO:007147840.012
regulation of phGO:000688530.012
regulation of dna replicationGO:000627530.012
regulation of programmed cell deathGO:00430671010.012
chemotaxisGO:00069351040.012
positive regulation of blood circulationGO:190352420.012
regulation of protein import into nucleusGO:004230620.012
gland developmentGO:00487321430.012
regulation of blood pressureGO:000821710.012
somatic muscle developmentGO:000752540.012
positive regulation of synaptic growth at neuromuscular junctionGO:004588710.012
stem cell divisionGO:001714510.012
secondary metabolic processGO:001974830.012
transcription from rna polymerase ii promoterGO:0006366800.012
cellular protein catabolic processGO:004425740.012
regulation of rna metabolic processGO:00512522240.012
organelle assemblyGO:00709251100.012
regulation of sequestering of calcium ionGO:005128240.012
regulation of transcription dna templatedGO:00063552130.012
catechol containing compound metabolic processGO:000971220.012
negative regulation of nitrogen compound metabolic processGO:0051172590.012
positive regulation of cell divisionGO:005178120.012
regulation of oocyte developmentGO:006028130.011
positive regulation of immune effector processGO:000269930.011
response to glucocorticoidGO:005138410.011
cellular protein complex disassemblyGO:004362410.011
positive regulation of protein polymerizationGO:003227320.011
negative regulation of defense responseGO:003134820.011
deathGO:00162651210.011
protein dephosphorylationGO:000647030.011
establishment of protein localization to plasma membraneGO:009000210.011
response to woundingGO:00096111160.011
regulation of neurotransmitter transportGO:005158810.011
cellular response to hypoxiaGO:007145610.011
response to xenobiotic stimulusGO:0009410450.011
regulation of glucose importGO:004632410.011
cation transportGO:0006812810.011
regulation of sodium ion transportGO:000202820.011
meiotic nuclear divisionGO:000712640.011
cell deathGO:00082191210.011
response to oxygen containing compoundGO:1901700550.011
negative regulation of macromolecule metabolic processGO:0010605760.011
negative regulation of protein complex assemblyGO:003133310.011
regulation of response to nutrient levelsGO:003210710.011
negative regulation of cytokine productionGO:000181810.011
response to external biotic stimulusGO:0043207970.011
protein heterooligomerizationGO:005129110.011
protein acetylationGO:000647320.011
internal protein amino acid acetylationGO:000647520.011
regulation of reactive oxygen species metabolic processGO:200037720.011
positive regulation of glucose transportGO:001082810.011
response to vitaminGO:003327330.011
wound healingGO:0042060900.011
actin mediated cell contractionGO:007025210.011
circulatory system processGO:0003013870.011
digestive tract morphogenesisGO:00485462310.011
maternal determination of anterior posterior axis embryoGO:000835840.011
hematopoietic or lymphoid organ developmentGO:00485341910.011
cellular lipid catabolic processGO:004424230.011
circadian sleep wake cycle processGO:002241020.011
axon ensheathment in central nervous systemGO:003229120.011
regulation of cell substrate adhesionGO:001081010.011
cellular protein modification processGO:00064641000.011
cellular response to molecule of bacterial originGO:007121930.011
regenerationGO:0031099910.011
positive regulation of cellular amino acid metabolic processGO:004576400.011
purine nucleoside monophosphate catabolic processGO:000912840.011
cellular protein metabolic processGO:00442671290.011
ear developmentGO:00435831270.011
positive regulation of lipid metabolic processGO:004583410.011
regulation of nucleotide catabolic processGO:003081120.011
cellular response to decreased oxygen levelsGO:003629410.011
response to radiationGO:0009314510.011
cellular response to light stimulusGO:007148240.011
regulation of cell developmentGO:00602841000.011
apoptotic processGO:00069151160.011
regulation of cell differentiationGO:00455951420.011
fat soluble vitamin metabolic processGO:000677540.011
circadian sleep wake cycleGO:004274520.011
action potentialGO:0001508190.011
protein modification processGO:00362111000.011
melanin metabolic processGO:000658220.010
organic substance transportGO:0071702580.010
regulation of membrane potentialGO:0042391230.010
inner ear developmentGO:00488391260.010
pigmentationGO:0043473850.010
cortical actin cytoskeleton organizationGO:003086610.010
positive regulation of reproductive processGO:200024320.010
peptidyl lysine acetylationGO:001839420.010
negative regulation of cytoplasmic transportGO:190365020.010
b cell mediated immunityGO:001972430.010
alpha amino acid metabolic processGO:190160530.010
multi organism processGO:00517041340.010
regulation of stem cell proliferationGO:007209120.010
regulation of cell deathGO:00109411030.010
positive regulation of cell substrate adhesionGO:001081110.010
carbohydrate derivative biosynthetic processGO:1901137430.010
positive regulation of multi organism processGO:004390230.010
endosome organizationGO:000703220.010
catecholamine metabolic processGO:000658420.010
neurological system processGO:0050877620.010
negative regulation of protein serine threonine kinase activityGO:007190120.010
nuclear migrationGO:000709730.010
behaviorGO:0007610740.010
ovulation cycleGO:004269820.010

comtb disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.038
nervous system diseaseDOID:86300.018
musculoskeletal system diseaseDOID:1700.012
disease of cellular proliferationDOID:1456600.012
disease of metabolismDOID:001466700.012
inherited metabolic disorderDOID:65500.012
cancerDOID:16200.011
organ system cancerDOID:005068600.010