Danio rerio

0 known processes

apaf1

apoptotic protease activating factor 1

(Aliases: MGC92565,zgc:136543,MGC136543)

apaf1 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
larval developmentGO:000216420.327
response to stressGO:00069502630.244
cellular nitrogen compound biosynthetic processGO:00442712180.133
signal transductionGO:00071654550.130
negative regulation of cellular processGO:00485232830.129
establishment of localizationGO:00512342440.120
neuron projection morphogenesisGO:00488121610.113
cellular aromatic compound metabolic processGO:00067252950.110
regulation of synapse organizationGO:005080730.110
positive regulation of transportGO:005105020.107
glucose importGO:004632320.105
response to chemicalGO:00422213200.102
nuclear transportGO:005116940.099
agingGO:000756820.098
positive regulation of cellular component biogenesisGO:004408930.095
cellular macromolecule metabolic processGO:00442603910.093
Human
nitrogen compound metabolic processGO:00068073190.093
cognitionGO:005089010.093
cell projection morphogenesisGO:00488582440.091
response to external stimulusGO:00096052640.088
transportGO:00068102200.083
single organism localizationGO:19025782250.081
nucleocytoplasmic transportGO:000691340.081
cellular component movementGO:00069283350.080
single organism transportGO:00447652060.080
autophagyGO:000691440.079
regulation of establishment of protein localizationGO:007020140.078
cell projection organizationGO:00300302840.075
regulation of cellular metabolic processGO:00313233200.074
Human
regulation of multicellular organismal developmentGO:20000262230.073
ubiquitin dependent protein catabolic processGO:000651130.073
heterocycle metabolic processGO:00464832900.071
cell morphogenesisGO:00009022890.069
cellular component morphogenesisGO:00329893360.069
nucleic acid templated transcriptionGO:00976591810.068
phagocytosisGO:000690930.067
neuron differentiationGO:00301823530.067
regulation of cell differentiationGO:00455951420.065
positive regulation of cell killingGO:003134320.065
central nervous system developmentGO:00074173870.064
aromatic compound biosynthetic processGO:00194382170.064
protein localization to nucleusGO:003450430.063
synaptic growth at neuromuscular junctionGO:005112420.063
developmental growthGO:00485891660.062
regulation of response to stimulusGO:00485832690.061
cellular protein catabolic processGO:004425740.061
multicellular organism growthGO:003526440.060
cell part morphogenesisGO:00329902460.060
response to organic substanceGO:00100331530.060
negative regulation of cell communicationGO:0010648960.059
regulation of multicellular organismal processGO:00512392770.059
brain developmentGO:00074202930.059
nucleic acid metabolic processGO:00903042440.058
regulation of localizationGO:00328791040.058
cellular nitrogen compound metabolic processGO:00346412900.058
cell surface receptor signaling pathwayGO:00071663250.057
regulation of protein transportGO:005122330.057
regulation of protein localization to nucleusGO:190018020.056
protein metabolic processGO:00195381830.056
Human
post embryonic organ developmentGO:004856940.055
modification dependent protein catabolic processGO:001994130.054
regulation of cellular biosynthetic processGO:00313262450.054
nucleobase containing compound metabolic processGO:00061392740.054
maintenance of locationGO:005123540.053
morphogenesis of an epitheliumGO:00020093330.053
regulation of protein complex assemblyGO:004325430.053
regulation of stem cell differentiationGO:200073640.052
regulation of signalingGO:00230512350.052
regulation of synapse assemblyGO:005196330.051
embryo development ending in birth or egg hatchingGO:00097922710.051
regulation of metabolic processGO:00192223590.051
Human
organonitrogen compound metabolic processGO:1901564740.051
chordate embryonic developmentGO:00430092710.050
organelle organizationGO:00069962270.050
positive regulation of cell cycleGO:004578730.049
single organism metabolic processGO:00447102170.049
negative regulation of biological processGO:00485193040.049
rna metabolic processGO:00160702190.049
biosynthetic processGO:00090582940.049
regulation of protein targetingGO:190353320.049
anterior posterior pattern specificationGO:00099521520.048
regulation of signal transductionGO:00099662250.048
cell morphogenesis involved in neuron differentiationGO:00486671630.047
microtubule organizing center organizationGO:003102310.047
heterocycle biosynthetic processGO:00181302150.047
regulation of cytoplasmic transportGO:190364940.047
extrinsic apoptotic signaling pathwayGO:009719130.047
regulation of nitrogen compound metabolic processGO:00511712510.046
organic cyclic compound biosynthetic processGO:19013622230.046
cellular biosynthetic processGO:00442492860.046
intracellular signal transductionGO:0035556850.045
regionalizationGO:00030022740.045
positive regulation of macromolecule metabolic processGO:0010604930.045
Human
regulation of intracellular protein transportGO:003315730.045
small molecule metabolic processGO:0044281770.045
proteolysis involved in cellular protein catabolic processGO:005160330.045
cellular carbohydrate metabolic processGO:004426240.045
positive regulation of catabolic processGO:000989640.045
regulation of rna metabolic processGO:00512522240.044
regulation of extrinsic apoptotic signaling pathwayGO:200123630.044
generation of neuronsGO:00486993850.044
cellular component biogenesisGO:00440851780.043
modification dependent macromolecule catabolic processGO:004363230.043
adherens junction organizationGO:003433240.043
negative regulation of synapse assemblyGO:005196420.043
gtp metabolic processGO:004603940.043
positive regulation of biological processGO:00485182530.042
Human
protein importGO:001703830.042
negative regulation of signalingGO:0023057960.042
regulation of nucleocytoplasmic transportGO:004682220.042
gtp catabolic processGO:000618420.042
positive regulation of protein complex assemblyGO:003133420.042
cellular response to radiationGO:007147840.041
regulation of developmental processGO:00507932470.041
centrosome organizationGO:005129710.041
guanosine containing compound catabolic processGO:190106920.041
regulation of protein import into nucleusGO:004230620.041
guanosine containing compound metabolic processGO:190106840.040
establishment of protein localization to organelleGO:007259440.040
transcription dna templatedGO:00063511810.040
cellular response to external stimulusGO:007149620.040
immune system processGO:00023762410.040
regulation of cell communicationGO:00106462320.040
convergent extensionGO:00600261180.040
regulation of rna biosynthetic processGO:20011412130.040
digestive system developmentGO:00551232890.039
regulation of circadian rhythmGO:004275240.039
organic substance biosynthetic processGO:19015762890.039
negative regulation of cytoplasmic transportGO:190365020.039
nucleobase containing compound biosynthetic processGO:00346542050.039
protein targeting to nucleusGO:004474430.039
meiotic nuclear divisionGO:000712640.038
ameboidal type cell migrationGO:00016671430.038
neuron projection developmentGO:00311751800.038
negative regulation of catabolic processGO:000989530.038
negative regulation of nucleocytoplasmic transportGO:004682320.038
proteasome mediated ubiquitin dependent protein catabolic processGO:004316120.038
macromolecule biosynthetic processGO:00090592270.038
system processGO:00030081850.037
female sex differentiationGO:004666040.037
cellular response to stressGO:0033554620.037
cytokinesisGO:000091030.037
gene expressionGO:00104672520.037
Human
positive regulation of cellular processGO:00485222010.037
Human
regulation of multicellular organism growthGO:004001440.037
regulation of synaptic growth at neuromuscular junctionGO:000858210.036
stem cell maintenanceGO:001982740.036
phosphate containing compound metabolic processGO:00067961080.036
rna biosynthetic processGO:00327741810.036
cellular response to organic substanceGO:00713101050.036
immune system developmentGO:00025201910.036
regulation of organ growthGO:004662030.035
head developmentGO:00603223030.035
heart developmentGO:00075073130.035
actin polymerization or depolymerizationGO:000815420.035
locomotionGO:00400113130.035
organic substance transportGO:0071702580.035
negative regulation of ras protein signal transductionGO:004658010.035
regulation of protein catabolic processGO:004217610.034
regulation of glucose importGO:004632410.034
tube morphogenesisGO:00352393490.033
negative regulation of protein transportGO:005122430.033
regulation of nucleobase containing compound metabolic processGO:00192192500.033
regulation of cell projection assemblyGO:006049140.033
cellular amine metabolic processGO:004410620.033
cellular response to starvationGO:000926710.033
centrosome cycleGO:000709810.033
regulation of cell developmentGO:00602841000.033
growthGO:00400071740.033
positive regulation of jun kinase activityGO:004350720.033
cell morphogenesis involved in differentiationGO:00009041950.032
regulation of macromolecule metabolic processGO:00602553170.032
Human
positive regulation of jnk cascadeGO:004633030.032
positive regulation of nitrogen compound metabolic processGO:0051173690.032
regulation of cellular macromolecule biosynthetic processGO:20001122220.031
regulation of cellular amine metabolic processGO:003323800.031
positive regulation of stress activated mapk cascadeGO:003287430.031
rna localizationGO:000640340.031
embryonic organ morphogenesisGO:00485622740.031
regulation of biological qualityGO:00650082630.031
sleepGO:003043110.031
adult behaviorGO:003053420.031
macromolecule modificationGO:00434121110.031
organelle assemblyGO:00709251100.031
mitochondrion organizationGO:000700540.031
glucose homeostasisGO:004259310.031
cellular response to chemical stimulusGO:00708871570.030
protein modification processGO:00362111000.030
proteasomal protein catabolic processGO:001049820.030
apoptotic processGO:00069151160.030
Human
response to glucoseGO:000974930.030
regulation of cellular carbohydrate metabolic processGO:001067540.030
cellular protein modification processGO:00064641000.030
regulation of transcription dna templatedGO:00063552130.030
regulation of glucose transportGO:001082710.029
amine metabolic processGO:000930820.029
intracellular mrna localizationGO:000829810.029
regulation of cell killingGO:003134120.029
positive regulation of cellular catabolic processGO:003133130.029
cellular protein metabolic processGO:00442671290.029
Human
cellular macromolecule biosynthetic processGO:00346452240.029
regulation of purine nucleotide catabolic processGO:003312120.029
actin cytoskeleton organizationGO:0030036630.029
cell deathGO:00082191210.029
Human
neuron projection guidanceGO:0097485860.029
regulation of biosynthetic processGO:00098892500.029
regulation of dendrite developmentGO:005077330.029
neuron developmentGO:00486662620.029
determination of bilateral symmetryGO:00098552040.029
cellular response to extracellular stimulusGO:003166820.028
phagocytosis engulfmentGO:000691110.028
lipid storageGO:001991510.028
membrane invaginationGO:001032410.028
regulation of peptidase activityGO:0052547230.028
Human
phosphorylationGO:0016310690.028
regulation of cysteine type endopeptidase activity involved in apoptotic processGO:0043281200.028
Human
regulation of peptidyl tyrosine phosphorylationGO:005073010.028
positive regulation of stress activated protein kinase signaling cascadeGO:007030430.028
positive regulation of map kinase activityGO:004340630.028
regulation of macromolecule biosynthetic processGO:00105562250.028
segmentationGO:0035282970.027
cellular response to nutrient levelsGO:003166920.027
negative regulation of intracellular transportGO:003238730.027
response to woundingGO:00096111160.027
cellular component assemblyGO:00226071700.027
cytoskeleton organizationGO:0007010960.027
localization of cellGO:00516742440.027
cell migrationGO:00164772370.027
single organism nuclear importGO:190259330.027
negative regulation of multicellular organismal processGO:0051241690.027
hormone transportGO:000991420.027
protein import into nucleusGO:000660630.027
gland developmentGO:00487321430.027
response to hexoseGO:000974630.027
deathGO:00162651210.027
Human
female gonad developmentGO:000858540.027
axonogenesisGO:00074091520.026
hepaticobiliary system developmentGO:0061008980.026
intracellular transportGO:0046907320.026
phosphorus metabolic processGO:00067931090.026
negative regulation of signal transductionGO:0009968940.026
peptide transportGO:001583310.026
viral processGO:001603210.026
regulation of cell activationGO:005086510.026
regulation of catalytic activityGO:0050790550.026
Human
regulation of protein modification by small protein conjugation or removalGO:190332030.026
positive regulation of immune effector processGO:000269930.026
synaptic vesicle localizationGO:009747910.026
regulation of cytokine productionGO:000181730.026
gastrulationGO:00073692080.025
regulation of dendrite morphogenesisGO:004881430.025
cell motilityGO:00488702440.025
carbohydrate homeostasisGO:003350010.025
positive regulation of muscle organ developmentGO:004863610.025
positive regulation of secretion by cellGO:190353210.025
protein localization to plasma membraneGO:007265910.025
modulation by virus of host morphology or physiologyGO:001904810.025
mitotic dna integrity checkpointGO:004477440.025
nuclear importGO:005117030.025
regulation of primary metabolic processGO:00800903110.025
Human
calcium ion importGO:007050940.025
establishment of protein localization to plasma membraneGO:009000210.025
muscle organ developmentGO:00075171010.025
cortical cytoskeleton organizationGO:003086510.025
locomotor rhythmGO:004547530.025
negative regulation of protein complex assemblyGO:003133310.025
proteolysisGO:0006508380.025
Human
regulation of intracellular signal transductionGO:1902531570.024
negative regulation of metabolic processGO:0009892860.024
programmed cell deathGO:00125011190.024
Human
axon developmentGO:00615641660.024
regulation of endopeptidase activityGO:0052548230.024
Human
organic cyclic compound metabolic processGO:19013603010.024
negative regulation of protein kinase activityGO:000646940.024
regulation of organelle assemblyGO:190211540.024
regulation of nucleoside metabolic processGO:000911820.024
regulation of nucleic acid templated transcriptionGO:19035062130.024
endosomal transportGO:001619720.024
regulation of carbohydrate metabolic processGO:000610940.024
cell cycleGO:0007049930.024
negative regulation of protein localization to nucleusGO:190018120.024
epithelial tube morphogenesisGO:00605621480.024
ras protein signal transductionGO:000726570.024
interspecies interaction between organismsGO:004441940.024
stem cell proliferationGO:007208940.024
regulation of synaptic plasticityGO:004816710.024
regulation of reproductive processGO:200024140.023
response to monosaccharideGO:003428430.023
cellular ketone metabolic processGO:0042180110.023
regulation of bindingGO:005109830.023
organelle localizationGO:0051640490.023
zymogen activationGO:003163830.023
Human
forebrain developmentGO:0030900960.023
positive regulation of carbohydrate metabolic processGO:004591310.023
negative regulation of intracellular protein transportGO:009031730.023
actin filament based processGO:0030029640.023
regulation of blood pressureGO:000821710.023
developmental growth involved in morphogenesisGO:0060560860.023
cell matrix adhesionGO:000716040.023
regulation of cellular protein metabolic processGO:0032268520.022
Human
development of primary female sexual characteristicsGO:004654540.022
response to uvGO:000941130.022
stem cell divisionGO:001714510.022
developmental cell growthGO:0048588520.022
positive regulation of cell adhesionGO:004578510.022
regulation of cellular amino acid metabolic processGO:000652100.022
negative regulation of protein phosphorylationGO:000193340.022
purine ribonucleoside monophosphate catabolic processGO:000916940.022
cell substrate adhesionGO:003158940.022
negative regulation of protein import into nucleusGO:004230820.022
regulation of molecular functionGO:0065009700.022
Human
single organism organelle organizationGO:19025891990.022
negative regulation of protein serine threonine kinase activityGO:007190120.022
axon guidanceGO:0007411860.021
positive regulation of apoptotic signaling pathwayGO:200123510.021
apoptotic process involved in developmentGO:190274220.021
symbiosis encompassing mutualism through parasitismGO:004440340.021
meiotic cell cycle processGO:190304630.021
negative regulation of small gtpase mediated signal transductionGO:005105810.021
hemopoiesisGO:00300971830.021
regulation of response to extracellular stimulusGO:003210410.021
regulation of programmed cell deathGO:00430671010.021
Human
neuroblast proliferationGO:000740520.021
taxisGO:00423301090.021
multi organism processGO:00517041340.021
regulation of gtp catabolic processGO:003312420.021
positive regulation of neuron apoptotic processGO:004352510.021
protein secretionGO:000930610.021
cellular response to hormone stimulusGO:0032870390.021
cell killingGO:000190620.021
establishment of localization in cellGO:0051649770.021
regulation of nucleotide catabolic processGO:003081120.020
regulation of phosphorus metabolic processGO:0051174430.020
peptidyl serine phosphorylationGO:001810510.020
regulation of autophagyGO:001050630.020
positive regulation of cytoskeleton organizationGO:005149530.020
response to corticosteroidGO:003196010.020
regulation of gene expressionGO:00104682650.020
regulation of cell deathGO:00109411030.020
Human
lateral inhibitionGO:004633110.020
hormone secretionGO:004687920.020
negative regulation of map kinase activityGO:004340720.020
pyruvate metabolic processGO:000609010.020
germ line stem cell maintenanceGO:003071820.020
muscle structure developmentGO:00610611960.020
liver developmentGO:0001889960.020
embryonic skeletal system developmentGO:0048706970.020
positive regulation of cell communicationGO:0010647560.020
spindle assemblyGO:005122520.020
membrane fusionGO:006102520.020
regulation of nervous system developmentGO:0051960900.020
stem cell differentiationGO:00488631170.019
regulation of cellular component organizationGO:0051128860.019
motor neuron axon guidanceGO:0008045230.019
wnt signaling pathwayGO:0016055800.019
cell cycle g1 s phase transitionGO:004484310.019
blood vessel developmentGO:00015682460.019
negative regulation of developmental processGO:0051093650.019
vasculature developmentGO:00019442780.019
protein dephosphorylationGO:000647030.019
embryonic skeletal system morphogenesisGO:0048704930.019
negative regulation of tor signalingGO:003200720.019
regulation of tube sizeGO:003515020.018
tissue remodelingGO:004877140.018
regulation of anatomical structure morphogenesisGO:00226031300.018
regulation of cell matrix adhesionGO:000195210.018
peptidyl serine modificationGO:001820920.018
negative regulation of response to stimulusGO:00485851040.018
g1 s transition of mitotic cell cycleGO:000008210.018
synaptic vesicle transportGO:004848910.018
response to external biotic stimulusGO:0043207970.018
embryonic organ developmentGO:00485683810.018
positive regulation of biosynthetic processGO:0009891680.018
skeletal muscle organ developmentGO:0060538780.018
regulation of proteolysisGO:0030162240.018
Human
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domainsGO:000246040.018
regulation of circadian sleep wake cycle sleepGO:004518710.018
negative regulation of mapk cascadeGO:004340940.018
negative chemotaxisGO:005091910.017
response to light stimulusGO:0009416460.017
multi organism cellular processGO:004476420.017
regulation of cysteine type endopeptidase activityGO:2000116210.017
Human
positive regulation of secretionGO:005104710.017
hematopoietic or lymphoid organ developmentGO:00485341910.017
axon extensionGO:0048675450.017
regulation of cell morphogenesis involved in differentiationGO:0010769380.017
ribonucleotide metabolic processGO:0009259270.017
protein complex subunit organizationGO:0071822460.017
regulation of gtpase activityGO:004308720.017
response to carbohydrateGO:000974330.017
response to drugGO:004249330.017
extrinsic apoptotic signaling pathway via death domain receptorsGO:000862510.017
cytoplasm organizationGO:000702840.017
regulation of reactive oxygen species metabolic processGO:200037720.017
circadian sleep wake cycle sleepGO:005080210.017
chemotaxisGO:00069351040.017
positive regulation of leukocyte differentiationGO:190210710.017
tube closureGO:006060610.017
positive regulation of cellular protein metabolic processGO:0032270220.017
Human
maternal determination of anterior posterior axis embryoGO:000835840.017
fertilizationGO:000956630.017
response to biotic stimulusGO:0009607970.017
determination of left right symmetryGO:00073681790.017
regulation of filopodium assemblyGO:005148920.016
canonical wnt signaling pathwayGO:0060070480.016
regulation of rho protein signal transductionGO:003502320.016
sex determinationGO:000753010.016
ribonucleoside monophosphate catabolic processGO:000915840.016
negative regulation of kinase activityGO:003367340.016
positive regulation of protein polymerizationGO:003227320.016
protein homooligomerizationGO:005126030.016
regulation of blood vessel sizeGO:005088020.016
carboxylic acid metabolic processGO:0019752220.016
transcription from rna polymerase ii promoterGO:0006366800.016
killing of cells in other organism involved in symbiotic interactionGO:005188310.016
skeletal system developmentGO:00015011810.016
regulation of inflammatory responseGO:005072720.016
regulation of metal ion transportGO:001095940.016
neurological system processGO:0050877620.016
cellular response to endogenous stimulusGO:0071495680.016
interaction with hostGO:005170140.016
protein polymerizationGO:005125840.016
epithelial cell differentiationGO:00308551160.016
response to glucocorticoidGO:005138410.016
negative regulation of cellular catabolic processGO:003133030.016
regulation of cellular ketone metabolic processGO:001056570.016
establishment of synaptic vesicle localizationGO:009748010.016
positive regulation of purine nucleotide catabolic processGO:003312310.015
transmembrane receptor protein tyrosine kinase signaling pathwayGO:0007169420.015
somatic muscle developmentGO:000752540.015
response to ketoneGO:190165410.015
leukocyte differentiationGO:0002521250.015
negative regulation of stem cell differentiationGO:200073720.015
atp catabolic processGO:000620040.015
negative regulation of extrinsic apoptotic signaling pathwayGO:200123720.015
regulation of wound healingGO:006104120.015
positive regulation of notch signaling pathwayGO:004574730.015
regulation of cell shapeGO:000836010.015
cellular component disassemblyGO:002241110.015
spermatid developmentGO:000728620.015
neuron neuron synaptic transmissionGO:000727010.015
regenerationGO:0031099910.015
microtubule based movementGO:0007018330.015
regulation of oocyte developmentGO:006028130.015
cell growthGO:0016049570.015
regulation of hormone secretionGO:004688320.015
p38mapk cascadeGO:003806610.015
regulation of jak stat cascadeGO:004642530.015
regulation of cellular protein catabolic processGO:190336210.015
regulation of cellular component sizeGO:0032535300.015
purine nucleoside monophosphate catabolic processGO:000912840.015
positive regulation of gtpase activityGO:004354710.015
spermatid differentiationGO:004851520.015
regulation of protein ubiquitinationGO:003139630.015
regulation of cell substrate adhesionGO:001081010.015
regulation of symbiosis encompassing mutualism through parasitismGO:004390310.014
positive regulation of neuron deathGO:190121610.014
cellular amino acid metabolic processGO:000652070.014
regulation of protein bindingGO:004339330.014
female meiotic divisionGO:000714320.014
regulation of protein polymerizationGO:003227120.014
digestive tract developmentGO:00485652650.014
regulation of neurogenesisGO:0050767870.014
cellular response to oxygen levelsGO:007145310.014
regulation of jun kinase activityGO:004350630.014
regulation of cell projection organizationGO:0031344440.014
negative regulation of nucleobase containing compound metabolic processGO:0045934590.014
response to hormoneGO:0009725480.014
positive regulation of cell deathGO:0010942290.014
Human
small gtpase mediated signal transductionGO:000726480.014
organic acid metabolic processGO:0006082310.014
positive regulation of metabolic processGO:00098931080.014
Human
protein phosphorylationGO:0006468470.014
nuclear exportGO:005116810.014
positive regulation of cellular carbohydrate metabolic processGO:001067610.014
synapsisGO:000712910.014
circadian sleep wake cycle processGO:002241020.014
regulation of response to stressGO:0080134360.014
regulation of anatomical structure sizeGO:0090066330.014
type b pancreatic cell developmentGO:000332340.014
response to oxygen containing compoundGO:1901700550.014
response to nutrientGO:000758430.014
killing of cells of other organismGO:003164010.014
blood vessel morphogenesisGO:00485142160.014
activation of jun kinase activityGO:000725720.014
circadian sleep wake cycleGO:004274520.014
modification of morphology or physiology of other organism involved in symbiotic interactionGO:005181740.014
regulation of dna replicationGO:000627530.014
circulatory system processGO:0003013870.014

apaf1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.041
disease of metabolismDOID:001466700.020
disease of cellular proliferationDOID:1456600.020
organ system cancerDOID:005068600.020
cancerDOID:16200.020
muscle tissue diseaseDOID:6600.019
myopathyDOID:42300.019
muscular diseaseDOID:008000000.019
musculoskeletal system diseaseDOID:1700.019
inherited metabolic disorderDOID:65500.015