Danio rerio

0 known processes

scn4ab

sodium channel, voltage-gated, type IV, alpha, b

(Aliases: Nav1.4b)

scn4ab biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
muscle structure developmentGO:00610611960.778
transmembrane transportGO:00550851200.513
Zebrafish Mouse
muscle cell developmentGO:00550011150.500
ion transmembrane transportGO:0034220910.479
Zebrafish Mouse
cardiac conductionGO:006133730.348
central nervous system developmentGO:00074173870.305
embryonic organ morphogenesisGO:00485622740.259
determination of bilateral symmetryGO:00098552040.240
muscle tissue developmentGO:00605371100.234
sodium ion transmembrane transportGO:0035725210.224
Zebrafish Mouse
striated muscle tissue developmentGO:00147061100.209
heart developmentGO:00075073130.200
muscle cell differentiationGO:00426921390.199
multicellular organismal signalingGO:0035637220.173
Zebrafish
specification of symmetryGO:00097992040.159
heart morphogenesisGO:00030071560.148
striated muscle cell differentiationGO:00511461290.142
myofibril assemblyGO:0030239480.136
cellular component assemblyGO:00226071700.125
cell projection morphogenesisGO:00488582440.122
Zebrafish
regulation of cell developmentGO:00602841000.117
transmission of nerve impulseGO:0019226190.110
Zebrafish
regulation of signalingGO:00230512350.108
skeletal muscle organ developmentGO:0060538780.107
intrinsic apoptotic signaling pathway in response to oxidative stressGO:000863120.107
regulation of neurogenesisGO:0050767870.106
striated muscle cell developmentGO:00550021080.099
muscle organ developmentGO:00075171010.098
determination of left right symmetryGO:00073681790.094
cell part morphogenesisGO:00329902460.093
Zebrafish
regulation of multicellular organismal processGO:00512392770.092
regulation of dendrite developmentGO:005077330.092
muscle fiber developmentGO:0048747520.088
regulation of biological qualityGO:00650082630.087
Zebrafish
locomotionGO:00400113130.087
Zebrafish
larval developmentGO:000216420.086
cellular aldehyde metabolic processGO:000608140.085
membrane repolarizationGO:008600920.084
positive regulation of transportGO:005105020.083
adult behaviorGO:003053420.080
cellular component biogenesisGO:00440851780.077
system processGO:00030081850.077
Zebrafish
negative regulation of cellular processGO:00485232830.077
cardiac muscle cell differentiationGO:0055007300.072
agingGO:000756820.070
transportGO:00068102200.069
Zebrafish Mouse
skeletal muscle thin filament assemblyGO:003024040.068
heart loopingGO:0001947940.068
heart processGO:0003015710.066
sarcomerogenesisGO:004876940.066
inorganic ion transmembrane transportGO:0098660570.062
Zebrafish Mouse
embryonic organ developmentGO:00485683810.062
neuron projection developmentGO:00311751800.061
Zebrafish
regulation of cellular macromolecule biosynthetic processGO:20001122220.061
regulation of rna biosynthetic processGO:20011412130.061
cellular amine metabolic processGO:004410620.059
regulation of synaptic plasticityGO:004816710.059
regulation of biosynthetic processGO:00098892500.058
single organism organelle organizationGO:19025891990.057
embryonic heart tube morphogenesisGO:00031431080.057
brain developmentGO:00074202930.057
regulation of neuron projection developmentGO:0010975400.057
cation transmembrane transportGO:0098655650.056
Zebrafish Mouse
signal transductionGO:00071654550.056
skeletal system developmentGO:00015011810.055
inorganic cation transmembrane transportGO:0098662500.052
Zebrafish Mouse
sensory organ developmentGO:00074233930.052
cardiac muscle fiber developmentGO:004873930.052
head developmentGO:00603223030.052
cell morphogenesisGO:00009022890.051
Zebrafish
regulation of cell differentiationGO:00455951420.049
morphogenesis of an epitheliumGO:00020093330.049
regulation of cell projection organizationGO:0031344440.049
purine nucleoside monophosphate catabolic processGO:000912840.047
cellular component morphogenesisGO:00329893360.047
Zebrafish
oxidative phosphorylationGO:000611910.047
tube morphogenesisGO:00352393490.046
stem cell proliferationGO:007208940.046
cell surface receptor signaling pathwayGO:00071663250.046
cellular component movementGO:00069283350.046
Zebrafish
cell motilityGO:00488702440.046
skeletal muscle tissue developmentGO:0007519670.045
establishment of localizationGO:00512342440.045
Zebrafish Mouse
macromolecule biosynthetic processGO:00090592270.044
cell death in response to oxidative stressGO:003647320.044
regulation of cytokine productionGO:000181730.043
positive regulation of cytokine productionGO:000181920.042
skeletal muscle fiber developmentGO:0048741350.042
response to chemicalGO:00422213200.042
Zebrafish
determination of heart left right asymmetryGO:00613711170.041
regulation of macromolecule biosynthetic processGO:00105562250.041
regulation of cellular amino acid metabolic processGO:000652100.040
biosynthetic processGO:00090582940.040
regulation of skeletal muscle tissue developmentGO:004864140.040
muscle contractionGO:0006936180.039
cellular biosynthetic processGO:00442492860.038
regulation of response to stimulusGO:00485832690.038
heart contractionGO:0060047710.038
amine metabolic processGO:000930820.037
astrocyte differentiationGO:004870810.037
negative regulation of oxidative stress induced intrinsic apoptotic signaling pathwayGO:190217620.037
response to organic substanceGO:00100331530.036
defense responseGO:0006952470.036
negative regulation of extrinsic apoptotic signaling pathwayGO:200123720.036
single organism localizationGO:19025782250.036
Zebrafish Mouse
regulation of synapse organizationGO:005080730.035
regulation of multicellular organismal developmentGO:20000262230.035
response to stressGO:00069502630.035
regulation of cellular amine metabolic processGO:003323800.034
response to external stimulusGO:00096052640.034
Zebrafish
nucleobase containing compound biosynthetic processGO:00346542050.034
cell matrix adhesionGO:000716040.033
regulation of bindingGO:005109830.033
organelle assemblyGO:00709251100.032
cardiac muscle tissue developmentGO:0048738480.032
peptidyl serine phosphorylationGO:001810510.032
regulation of reactive oxygen species metabolic processGO:200037720.032
central nervous system neuron developmentGO:0021954290.032
nucleic acid templated transcriptionGO:00976591810.032
regulation of developmental processGO:00507932470.032
organonitrogen compound metabolic processGO:1901564740.032
single organism metabolic processGO:00447102170.031
proteasomal protein catabolic processGO:001049820.031
heterocycle metabolic processGO:00464832900.031
localization of cellGO:00516742440.030
regulation of protein bindingGO:004339330.030
organic cyclic compound metabolic processGO:19013603010.030
positive regulation of muscle tissue developmentGO:190186310.029
regulation of nervous system developmentGO:0051960900.029
response to abiotic stimulusGO:00096281220.029
Zebrafish
circulatory system processGO:0003013870.029
oxoacid metabolic processGO:0043436310.029
negative regulation of biological processGO:00485193040.029
regulation of cardiac muscle contractionGO:005511720.029
transmembrane receptor protein serine threonine kinase signaling pathwayGO:0007178680.028
positive regulation of cellular component biogenesisGO:004408930.028
female sex differentiationGO:004666040.028
estrogen metabolic processGO:000821020.028
atp catabolic processGO:000620040.028
regulation of muscle contractionGO:000693730.028
regulation of transportGO:0051049450.028
Zebrafish Mouse
organic cyclic compound biosynthetic processGO:19013622230.028
meiotic nuclear divisionGO:000712640.027
rna metabolic processGO:00160702190.027
neuromuscular synaptic transmissionGO:000727420.027
organic acid metabolic processGO:0006082310.026
cellular amino acid metabolic processGO:000652070.026
reactive oxygen species biosynthetic processGO:190340910.026
small molecule metabolic processGO:0044281770.026
regulation of anatomical structure morphogenesisGO:00226031300.026
positive regulation of biological processGO:00485182530.026
cell morphogenesis involved in differentiationGO:00009041950.026
Zebrafish
motor neuron axon guidanceGO:0008045230.026
Zebrafish
transcription dna templatedGO:00063511810.026
embryonic heart tube developmentGO:00350501330.025
organic substance biosynthetic processGO:19015762890.025
neuron differentiationGO:00301823530.025
Zebrafish
regulation of neuron differentiationGO:0045664560.025
morphogenesis of an epithelial sheetGO:0002011490.025
epithelial tube morphogenesisGO:00605621480.024
swimming behaviorGO:003626980.024
Zebrafish
regulation of cellular biosynthetic processGO:00313262450.024
phagocytosisGO:000690930.024
cellular macromolecule metabolic processGO:00442603910.024
g protein coupled receptor signaling pathwayGO:0007186740.024
trabecula morphogenesisGO:006138320.024
regulation of oxidative stress induced intrinsic apoptotic signaling pathwayGO:190217520.024
ion transportGO:00068111140.024
Zebrafish Mouse
organelle organizationGO:00069962270.023
axonogenesisGO:00074091520.023
Zebrafish
regulation of protein catabolic processGO:004217610.023
regulation of skeletal muscle fiber developmentGO:004874220.022
regulation of organelle assemblyGO:190211540.022
regulation of membrane potentialGO:0042391230.022
Zebrafish
negative regulation of protein phosphorylationGO:000193340.022
nitrogen compound metabolic processGO:00068073190.022
negative regulation of protein kinase activityGO:000646940.022
gene expressionGO:00104672520.021
cellular carbohydrate metabolic processGO:004426240.021
transcription from rna polymerase ii promoterGO:0006366800.021
cell substrate adhesionGO:003158940.021
regulation of nitrogen compound metabolic processGO:00511712510.021
female gonad developmentGO:000858540.021
digestive tract morphogenesisGO:00485462310.021
regulation of stem cell proliferationGO:007209120.021
neuron developmentGO:00486662620.021
Zebrafish
reactive nitrogen species metabolic processGO:200105700.021
regulation of synapse assemblyGO:005196330.021
positive regulation of stem cell proliferationGO:200064810.020
cellular protein complex assemblyGO:0043623190.020
purine ribonucleoside monophosphate catabolic processGO:000916940.020
cellular component assembly involved in morphogenesisGO:00109271070.020
atp synthesis coupled electron transportGO:004277310.020
axon developmentGO:00615641660.020
Zebrafish
positive regulation of macromolecule metabolic processGO:0010604930.020
hormone biosynthetic processGO:004244630.020
peptidyl lysine methylationGO:001802230.020
cellular response to radiationGO:007147840.020
regulation of i kappab kinase nf kappab signalingGO:004312240.019
development of primary female sexual characteristicsGO:004654540.019
regulation of programmed cell deathGO:00430671010.019
regulation of response to oxidative stressGO:190288220.019
negative regulation of muscle tissue developmentGO:190186220.019
nucleobase containing compound metabolic processGO:00061392740.019
carbohydrate biosynthetic processGO:001605110.019
protein metabolic processGO:00195381830.018
protein stabilizationGO:005082120.018
cellular response to chemical stimulusGO:00708871570.018
cardiac atrium developmentGO:000323040.018
cellular response to steroid hormone stimulusGO:0071383310.018
inner ear developmentGO:00488391260.018
cellular nitrogen compound biosynthetic processGO:00442712180.018
proteolysis involved in cellular protein catabolic processGO:005160330.018
developmental growth involved in morphogenesisGO:0060560860.018
nucleoside monophosphate catabolic processGO:000912540.018
regulation of transcription from rna polymerase ii promoterGO:00063571140.018
post golgi vesicle mediated transportGO:000689210.018
positive regulation of blood circulationGO:190352420.018
mitochondrion organizationGO:000700540.018
ribonucleoside monophosphate catabolic processGO:000915840.018
blood vessel developmentGO:00015682460.018
protein complex assemblyGO:0006461300.018
cellular macromolecule biosynthetic processGO:00346452240.018
neuron projection guidanceGO:0097485860.018
Zebrafish
regulation of system processGO:0044057400.018
negative regulation of catalytic activityGO:0043086210.018
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathwayGO:0090101220.018
negative regulation of kinase activityGO:003367340.017
regulation of receptor activityGO:001046920.017
ubiquitin dependent protein catabolic processGO:000651130.017
regulation of cell communicationGO:00106462320.017
neuronal action potentialGO:0019228180.017
Zebrafish
positive regulation of muscle organ developmentGO:004863610.017
cytokinesisGO:000091030.017
cellular nitrogen compound metabolic processGO:00346412900.017
regulation of blood vessel sizeGO:005088020.017
regulation of membrane repolarizationGO:006030610.017
positive regulation of cell projection organizationGO:003134690.017
blood circulationGO:0008015870.017
positive regulation of multicellular organismal processGO:0051240520.017
developmental growthGO:00485891660.017
cardiac muscle myosin thick filament assemblyGO:007169010.016
regulation of transmembrane transporter activityGO:002289820.016
regulation of protein transportGO:005122330.016
bmp signaling pathwayGO:0030509520.016
neuroblast proliferationGO:000740520.016
nitric oxide biosynthetic processGO:000680920.016
carboxylic acid metabolic processGO:0019752220.016
cellular aromatic compound metabolic processGO:00067252950.016
mitotic dna damage checkpointGO:004477340.016
regulation of gene expressionGO:00104682650.016
protein complex biogenesisGO:0070271300.016
cell projection organizationGO:00300302840.015
Zebrafish
phosphorylationGO:0016310690.015
embryo development ending in birth or egg hatchingGO:00097922710.015
modification dependent protein catabolic processGO:001994130.015
rna biosynthetic processGO:00327741810.015
cellular response to organic substanceGO:00713101050.015
modification dependent macromolecule catabolic processGO:004363230.015
regulation of dendrite morphogenesisGO:004881430.015
central nervous system neuron axonogenesisGO:0021955180.015
chemotaxisGO:00069351040.015
Zebrafish
blood vessel morphogenesisGO:00485142160.015
regulation of extrinsic apoptotic signaling pathwayGO:200123630.015
positive regulation of heart contractionGO:004582320.015
negative regulation of programmed cell deathGO:0043069580.015
regulation of myotube differentiationGO:001083020.015
cellular protein modification processGO:00064641000.015
protein dephosphorylationGO:000647030.015
cell migrationGO:00164772370.015
negative regulation of multicellular organismal processGO:0051241690.015
aromatic compound biosynthetic processGO:00194382170.015
notochord developmentGO:0030903540.015
multicellular organismal response to stressGO:003355520.015
immune system processGO:00023762410.015
regulation of cellular ketone metabolic processGO:001056570.015
cardiac muscle cell contractionGO:008600310.015
peptide metabolic processGO:000651810.015
regulation of inflammatory responseGO:005072720.015
response to carbohydrateGO:000974330.015
cation transportGO:0006812810.014
Zebrafish Mouse
developmental cell growthGO:0048588520.014
actomyosin structure organizationGO:0031032530.014
gastrulationGO:00073692080.014
positive regulation of neuron projection developmentGO:001097690.014
cell morphogenesis involved in neuron differentiationGO:00486671630.014
Zebrafish
circadian sleep wake cycle sleepGO:005080210.014
proteasome mediated ubiquitin dependent protein catabolic processGO:004316120.014
regulation of nucleoside metabolic processGO:000911820.014
gastrulation with mouth forming secondGO:0001702440.014
chordate embryonic developmentGO:00430092710.014
neural crest formationGO:0014029140.014
heterocycle biosynthetic processGO:00181302150.014
regulation of rna metabolic processGO:00512522240.014
apoptotic processGO:00069151160.014
regulation of cell motilityGO:2000145460.013
mesenchymal cell differentiationGO:0048762870.013
regulation of synaptic growth at neuromuscular junctionGO:000858210.013
regulation of metabolic processGO:00192223590.013
regulation of dna replicationGO:000627530.013
endocardial cushion formationGO:000327220.013
regulation of organ growthGO:004662030.013
cellular ketone metabolic processGO:0042180110.013
vasculature developmentGO:00019442780.013
nitric oxide metabolic processGO:004620920.013
regulation of sarcomere organizationGO:006029720.013
cellular response to endogenous stimulusGO:0071495680.013
regulation of behaviorGO:0050795240.013
hormone metabolic processGO:0042445190.013
histone h3 k4 methylationGO:005156820.012
monovalent inorganic cation transportGO:0015672420.012
Zebrafish Mouse
response to monosaccharideGO:003428430.012
cardiocyte differentiationGO:0035051440.012
response to vitamin b3GO:003355220.012
larval behaviorGO:003053750.012
Zebrafish
positive regulation of peptidyl tyrosine phosphorylationGO:005073110.012
regulation of cellular component organizationGO:0051128860.012
response to uvGO:000941130.012
regulation of cell morphogenesis involved in differentiationGO:0010769380.012
regulation of cellular metabolic processGO:00313233200.012
dopamine metabolic processGO:004241720.012
regulation of protein complex assemblyGO:004325430.012
mesenchyme developmentGO:00604851270.012
regulation of oxidative stress induced cell deathGO:190320120.012
autophagyGO:000691440.012
embryonic limb morphogenesisGO:003032620.012
iron ion homeostasisGO:005507240.012
cardiac myofibril assemblyGO:005500390.012
alcohol biosynthetic processGO:004616520.012
histone phosphorylationGO:001657220.012
protein homooligomerizationGO:005126030.012
negative regulation of macromolecule metabolic processGO:0010605760.012
eye developmentGO:00016542770.012
cellular response to hormone stimulusGO:0032870390.012
defense response to other organismGO:0098542330.012
positive regulation of nucleic acid templated transcriptionGO:1903508570.012
negative regulation of striated muscle tissue developmentGO:004584320.012
negative regulation of bmp signaling pathwayGO:0030514130.012
actin filament based movementGO:003004810.012
cell substrate junction assemblyGO:000704420.012
anterior posterior pattern specificationGO:00099521520.012
sex determinationGO:000753010.012
protein modification processGO:00362111000.012
regulation of protein ubiquitinationGO:003139630.012
neurotransmitter transportGO:000683620.012
regulation of nucleobase containing compound metabolic processGO:00192192500.012
kidney developmentGO:0001822920.012
regulation of protein modification by small protein conjugation or removalGO:190332030.011
cellular protein catabolic processGO:004425740.011
regulation of apoptotic processGO:0042981980.011
regulation of transmembrane transportGO:0034762180.011
Zebrafish Mouse
positive regulation of cellular amino acid metabolic processGO:004576400.011
peptidyl serine modificationGO:001820920.011
regulation of ion transportGO:0043269220.011
Zebrafish Mouse
negative regulation of cytokine productionGO:000181810.011
regulation of bmp signaling pathwayGO:0030510390.011
cytoskeleton organizationGO:0007010960.011
positive regulation of skeletal muscle tissue developmentGO:004864310.011
programmed cell deathGO:00125011190.011
neuron projection morphogenesisGO:00488121610.011
Zebrafish
cell cell signalingGO:0007267520.011
organism emergence from protective structureGO:007168440.011
lipid homeostasisGO:005508830.011
response to hydrogen peroxideGO:004254230.011
locomotory behaviorGO:0007626340.011
Zebrafish
protein acetylationGO:000647320.011
rna localizationGO:000640340.011
regulation of localizationGO:00328791040.011
Zebrafish Mouse
regulation of primary metabolic processGO:00800903110.011
extrinsic apoptotic signaling pathwayGO:009719130.011
epithelial to mesenchymal transitionGO:0001837210.011
growthGO:00400071740.011
positive regulation of cell cycleGO:004578730.011
neural crest cell differentiationGO:0014033720.011
regulation of axonogenesisGO:0050770320.011
detection of mechanical stimulus involved in sensory perception of touchGO:005097620.011
myotube differentiationGO:0014902450.011
positive regulation of cellular amine metabolic processGO:003324000.011
negative regulation of cell deathGO:0060548600.011
regulation of signal transductionGO:00099662250.010
myeloid cell homeostasisGO:0002262560.010
neuron projection extensionGO:1990138450.010
regulation of cellular carbohydrate metabolic processGO:001067540.010
regulation of reproductive processGO:200024140.010
nucleic acid metabolic processGO:00903042440.010
specification of axis polarityGO:006500140.010
cellular response to estradiol stimulusGO:007139210.010
axis specificationGO:0009798430.010
cell migration involved in gastrulationGO:0042074790.010
establishment of protein localization to organelleGO:007259440.010
regenerationGO:0031099910.010

scn4ab disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
heart diseaseDOID:11400.077
cardiomyopathyDOID:005070000.077
disease of anatomical entityDOID:700.077
muscular diseaseDOID:008000000.077
muscle tissue diseaseDOID:6600.077
cardiovascular system diseaseDOID:128700.077
myopathyDOID:42300.077
musculoskeletal system diseaseDOID:1700.077
intrinsic cardiomyopathyDOID:006003600.049
nervous system diseaseDOID:86300.029
cancerDOID:16200.011
disease of cellular proliferationDOID:1456600.011