Danio rerio

0 known processes

map4k5

mitogen-activated protein kinase kinase kinase kinase 5

(Aliases: zgc:55719,zgc:55985,fl74c10,wu:fl74c10,MGC55719)

map4k5 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
larval developmentGO:000216420.367
blood vessel developmentGO:00015682460.178
meiotic nuclear divisionGO:000712640.164
negative regulation of protein kinase activityGO:000646940.126
chordate embryonic developmentGO:00430092710.124
negative regulation of protein phosphorylationGO:000193340.109
phagocytosisGO:000690930.079
cellular nitrogen compound metabolic processGO:00346412900.079
cellular component movementGO:00069283350.078
cellular macromolecule metabolic processGO:00442603910.077
Human Fly
single organism metabolic processGO:00447102170.076
Fly
regulation of multicellular organism growthGO:004001440.071
embryo development ending in birth or egg hatchingGO:00097922710.070
negative regulation of kinase activityGO:003367340.069
blood vessel morphogenesisGO:00485142160.067
vasculature developmentGO:00019442780.066
establishment of localizationGO:00512342440.064
positive regulation of transportGO:005105020.063
regulation of reproductive processGO:200024140.055
regulation of cellular component organizationGO:0051128860.054
heart developmentGO:00075073130.054
locomotionGO:00400113130.053
positive regulation of biological processGO:00485182530.053
Fly
organelle fusionGO:004828430.052
regulation of developmental processGO:00507932470.051
regulation of oocyte developmentGO:006028130.050
cellular response to external stimulusGO:007149620.049
establishment of protein localization to organelleGO:007259440.049
regulation of primary metabolic processGO:00800903110.049
localization of cellGO:00516742440.049
nitrogen compound metabolic processGO:00068073190.049
positive regulation of protein complex assemblyGO:003133420.049
cellular response to extracellular stimulusGO:003166820.048
cell morphogenesisGO:00009022890.048
rna metabolic processGO:00160702190.047
regulation of protein complex assemblyGO:004325430.047
nucleobase containing compound metabolic processGO:00061392740.047
cell cycleGO:0007049930.046
embryonic organ developmentGO:00485683810.045
regulation of cell developmentGO:00602841000.045
organelle organizationGO:00069962270.045
Fly
regulation of cellular metabolic processGO:00313233200.044
Fly
cell motilityGO:00488702440.044
cell cycle processGO:0022402530.043
cortical actin cytoskeleton organizationGO:003086610.043
regulation of nitrogen compound metabolic processGO:00511712510.043
agingGO:000756820.043
cellular biosynthetic processGO:00442492860.041
transcription dna templatedGO:00063511810.040
nucleocytoplasmic transportGO:000691340.040
proteasome mediated ubiquitin dependent protein catabolic processGO:004316120.040
cellular response to starvationGO:000926710.040
regulation of macromolecule metabolic processGO:00602553170.040
regulation of nucleobase containing compound metabolic processGO:00192192500.039
cell migrationGO:00164772370.039
negative regulation of cellular processGO:00485232830.039
Fly
negative regulation of biological processGO:00485193040.039
Fly
negative regulation of synapse assemblyGO:005196420.039
endocytosisGO:0006897160.038
cellular response to nutrient levelsGO:003166920.038
biosynthetic processGO:00090582940.038
transportGO:00068102200.037
tube morphogenesisGO:00352393490.037
heterocycle metabolic processGO:00464832900.037
lamellipodium assemblyGO:003003210.037
cortical cytoskeleton organizationGO:003086510.036
positive regulation of cellular component biogenesisGO:004408930.036
regulation of synaptic growth at neuromuscular junctionGO:000858210.035
regulation of cellular biosynthetic processGO:00313262450.035
generation of neuronsGO:00486993850.035
single organism organelle organizationGO:19025891990.035
phosphate containing compound metabolic processGO:00067961080.034
Human Fly
multicellular organism growthGO:003526440.034
somitogenesisGO:0001756870.034
regionalizationGO:00030022740.034
cell morphogenesis involved in differentiationGO:00009041950.034
single organism nuclear importGO:190259330.034
nuclear transportGO:005116940.034
positive regulation of protein polymerizationGO:003227320.034
response to drugGO:004249330.033
embryonic organ morphogenesisGO:00485622740.033
positive regulation of map kinase activityGO:004340630.033
protein targeting to nucleusGO:004474430.032
negative regulation of mapk cascadeGO:004340940.032
mitotic cell cycleGO:0000278640.032
negative regulation of protein serine threonine kinase activityGO:007190120.032
protein importGO:001703830.031
single organism transportGO:00447652060.031
gene expressionGO:00104672520.031
lamellipodium organizationGO:009758110.030
regulation of cell shapeGO:000836010.030
positive regulation of cytoskeleton organizationGO:005149530.029
regulation of multicellular organismal developmentGO:20000262230.029
activation of mapk activityGO:000018730.028
deathGO:00162651210.028
Fly
cellular nitrogen compound biosynthetic processGO:00442712180.028
liver developmentGO:0001889960.028
actin filament based movementGO:003004810.028
embryonic skeletal system developmentGO:0048706970.028
nuclear importGO:005117030.028
programmed cell deathGO:00125011190.028
Fly
positive regulation of catabolic processGO:000989640.028
nucleic acid templated transcriptionGO:00976591810.027
negative regulation of map kinase activityGO:004340720.027
protein metabolic processGO:00195381830.027
Human Fly
macroautophagyGO:001623610.027
regulation of cellular amine metabolic processGO:003323800.027
oxoacid metabolic processGO:0043436310.027
membrane invaginationGO:001032410.027
regulation of synapse organizationGO:005080730.027
response to chemicalGO:00422213200.027
Fly
gtp catabolic processGO:000618420.027
protein localization to nucleusGO:003450430.026
stem cell divisionGO:001714510.026
neuron differentiationGO:00301823530.026
protein polymerizationGO:005125840.026
stem cell proliferationGO:007208940.026
growthGO:00400071740.026
Fly
protein import into nucleusGO:000660630.025
regulation of multicellular organismal processGO:00512392770.025
positive regulation of stress activated mapk cascadeGO:003287430.025
Fly
positive regulation of cellular catabolic processGO:003133130.025
guanosine containing compound catabolic processGO:190106920.025
regulation of meiotic cell cycleGO:005144510.025
guanosine containing compound metabolic processGO:190106840.024
response to external stimulusGO:00096052640.024
regulation of cell communicationGO:00106462320.024
Fly
cell deathGO:00082191210.024
Fly
rna biosynthetic processGO:00327741810.024
meiotic cell cycle processGO:190304630.024
small molecule metabolic processGO:0044281770.024
establishment of synaptic vesicle localizationGO:009748010.024
regulation of protein catabolic processGO:004217610.024
regulation of cell differentiationGO:00455951420.024
membrane fusionGO:006102520.024
regulation of establishment of protein localizationGO:007020140.023
cellular protein catabolic processGO:004425740.023
regulation of metabolic processGO:00192223590.023
Fly
cell agingGO:000756920.023
response to stressGO:00069502630.023
Fly
developmental growthGO:00485891660.023
nucleic acid metabolic processGO:00903042440.023
regulation of peptidyl tyrosine phosphorylationGO:005073010.022
ubiquitin dependent protein catabolic processGO:000651130.022
cellular protein modification processGO:00064641000.022
Human Fly
negative regulation of response to stimulusGO:00485851040.022
Fly
apoptotic processGO:00069151160.022
Fly
carboxylic acid metabolic processGO:0019752220.022
production of molecular mediator of immune responseGO:000244020.021
regulation of rna biosynthetic processGO:20011412130.021
vacuolar transportGO:000703420.021
morphogenesis of an epitheliumGO:00020093330.021
regulation of neurogenesisGO:0050767870.021
embryonic skeletal system morphogenesisGO:0048704930.021
erk1 and erk2 cascadeGO:007037140.021
organic cyclic compound biosynthetic processGO:19013622230.021
regulation of nervous system developmentGO:0051960900.020
regulation of programmed cell deathGO:00430671010.020
Fly
positive regulation of stress activated protein kinase signaling cascadeGO:007030430.020
Fly
neuroblast proliferationGO:000740520.020
cell part morphogenesisGO:00329902460.020
proteasomal protein catabolic processGO:001049820.020
positive regulation of jnk cascadeGO:004633030.020
Fly
lipid storageGO:001991510.020
phosphorylationGO:0016310690.020
Human Fly
somite developmentGO:0061053960.020
gtp metabolic processGO:004603940.020
regulation of organelle organizationGO:0033043290.020
regulation of catalytic activityGO:0050790550.020
hepaticobiliary system developmentGO:0061008980.019
regulation of erk1 and erk2 cascadeGO:007037240.019
adult behaviorGO:003053420.019
Fly
single organism localizationGO:19025782250.019
cellular amine metabolic processGO:004410620.019
regulation of biosynthetic processGO:00098892500.019
regulation of stem cell proliferationGO:007209120.019
cytokinesisGO:000091030.019
epithelial tube morphogenesisGO:00605621480.019
endosomal transportGO:001619720.019
spindle assemblyGO:005122520.018
regulation of rna metabolic processGO:00512522240.018
actin filament polymerizationGO:003004120.018
regulation of gene expressionGO:00104682650.018
regulation of protein targetingGO:190353320.018
negative regulation of developmental processGO:0051093650.018
digestive tract developmentGO:00485652650.018
centrosome organizationGO:005129710.018
angiogenesisGO:00015251580.018
organic acid metabolic processGO:0006082310.018
regulation of gtp catabolic processGO:003312420.018
mechanosensory behaviorGO:000763820.018
regulation of cytoplasmic transportGO:190364940.018
organic substance biosynthetic processGO:19015762890.018
neuron projection developmentGO:00311751800.018
modification dependent macromolecule catabolic processGO:004363230.018
cellular ketone metabolic processGO:0042180110.018
primary neural tube formationGO:001402010.018
cytoskeleton dependent cytokinesisGO:006164030.017
regulation of nucleic acid templated transcriptionGO:19035062130.017
somatic stem cell maintenanceGO:003501910.017
regulation of gtpase activityGO:004308720.017
positive regulation of dna metabolic processGO:005105410.017
positive regulation of cell cycleGO:004578730.017
digestive system developmentGO:00551232890.017
regulation of cellular amino acid metabolic processGO:000652100.017
single organism membrane fusionGO:004480120.017
regulation of intracellular protein transportGO:003315730.017
negative regulation of multicellular organismal processGO:0051241690.017
sensory organ developmentGO:00074233930.017
amine metabolic processGO:000930820.017
regulation of protein transportGO:005122330.017
reactive nitrogen species metabolic processGO:200105700.017
female sex differentiationGO:004666040.017
transcription from rna polymerase ii promoterGO:0006366800.017
positive regulation of cell adhesionGO:004578510.017
regulation of response to cytokine stimulusGO:006075930.016
response to carbohydrateGO:000974330.016
segmentationGO:0035282970.016
regulation of purine nucleotide catabolic processGO:003312120.016
positive regulation of gtpase activityGO:004354710.016
cellular response to chemical stimulusGO:00708871570.016
Fly
skeletal system developmentGO:00015011810.016
axon developmentGO:00615641660.016
negative regulation of cell communicationGO:0010648960.016
Fly
regulation of protein bindingGO:004339330.016
negative regulation of innate immune responseGO:004582420.016
rna localizationGO:000640340.016
tube closureGO:006060610.016
cellular component biogenesisGO:00440851780.016
microtubule organizing center organizationGO:003102310.016
response to monosaccharideGO:003428430.016
cellular response to biotic stimulusGO:007121630.015
nucleobase containing compound biosynthetic processGO:00346542050.015
protein heterooligomerizationGO:005129110.015
macromolecule modificationGO:00434121110.015
Human Fly
reproductive processGO:0022414400.015
organic cyclic compound metabolic processGO:19013603010.015
epithelial cell morphogenesisGO:000338220.015
stem cell maintenanceGO:001982740.015
phosphorus metabolic processGO:00067931090.015
Human Fly
regulation of synapse assemblyGO:005196330.015
positive regulation of apoptotic signaling pathwayGO:200123510.015
regulation of localizationGO:00328791040.015
homeostatic processGO:00425921420.015
Fly
positive regulation of jun kinase activityGO:004350720.015
regulation of signal transductionGO:00099662250.015
Fly
regulation of biological qualityGO:00650082630.015
Fly
mitochondrion organizationGO:000700540.015
regulation of phosphate metabolic processGO:0019220430.015
Fly
response to hexoseGO:000974630.015
modification dependent protein catabolic processGO:001994130.015
regulation of cellular ketone metabolic processGO:001056570.015
cellular component morphogenesisGO:00329893360.015
cell substrate adhesionGO:003158940.015
multi organism processGO:00517041340.015
cell surface receptor signaling pathwayGO:00071663250.015
Fly
response to corticosteroidGO:003196010.015
anterior posterior pattern specificationGO:00099521520.015
cell adhesion mediated by integrinGO:003362710.014
negative regulation of cellular metabolic processGO:0031324770.014
immune system processGO:00023762410.014
regulation of response to stressGO:0080134360.014
Fly
autophagyGO:000691440.014
regulation of molecular functionGO:0065009700.014
cell projection organizationGO:00300302840.014
extrinsic apoptotic signaling pathwayGO:009719130.014
regulation of mitochondrion organizationGO:001082110.014
axonogenesisGO:00074091520.014
protein dephosphorylationGO:000647030.014
positive regulation of nucleotide catabolic processGO:003081310.014
actin mediated cell contractionGO:007025210.014
regulation of stem cell differentiationGO:200073640.014
macromolecule biosynthetic processGO:00090592270.014
synaptic target recognitionGO:000803910.014
regulation of jun kinase activityGO:004350630.013
actin polymerization or depolymerizationGO:000815420.013
cellular response to stressGO:0033554620.013
Fly
organonitrogen compound metabolic processGO:1901564740.013
heart morphogenesisGO:00030071560.013
cell death in response to oxidative stressGO:003647320.013
organelle fissionGO:0048285230.013
regulation of cell activationGO:005086510.013
neuron developmentGO:00486662620.013
regulation of cell deathGO:00109411030.013
Fly
negative regulation of sequence specific dna binding transcription factor activityGO:004343320.013
cognitionGO:005089010.013
mitotic nuclear divisionGO:0007067180.013
cellular aromatic compound metabolic processGO:00067252950.013
regulation of phosphorus metabolic processGO:0051174430.013
Fly
female meiotic divisionGO:000714320.013
regulation of filopodium assemblyGO:005148920.013
intracellular signal transductionGO:0035556850.013
Human Fly
golgi vesicle transportGO:004819330.013
mitochondrial transportGO:000683920.013
positive regulation of gtp catabolic processGO:003312610.013
regulation of response to biotic stimulusGO:000283120.013
central nervous system developmentGO:00074173870.013
synaptic vesicle transportGO:004848910.013
aromatic compound biosynthetic processGO:00194382170.012
regulation of reactive oxygen species metabolic processGO:200037720.012
regulation of anatomical structure morphogenesisGO:00226031300.012
germ cell developmentGO:0007281220.012
macromolecular complex subunit organizationGO:0043933740.012
meiotic chromosome segregationGO:004513230.012
mitotic cytokinesisGO:000028130.012
cellular localizationGO:0051641970.012
establishment of apical basal cell polarityGO:003508920.012
convergent extensionGO:00600261180.012
regulation of protein polymerizationGO:003227120.012
cellular amino acid metabolic processGO:000652070.012
g2 dna damage checkpointGO:003157230.012
regulation of bindingGO:005109830.012
regulation of cell projection assemblyGO:006049140.012
cell projection morphogenesisGO:00488582440.012
nitric oxide biosynthetic processGO:000680920.012
establishment of protein localization to vacuoleGO:007266610.012
adherens junction organizationGO:003433240.012
neural tube patterningGO:0021532330.012
mitotic cell cycle processGO:1903047480.011
cellular component disassemblyGO:002241110.011
positive regulation of camp metabolic processGO:003081620.011
neurotransmitter transportGO:000683620.011
positive regulation of stem cell proliferationGO:200064810.011
negative regulation of response to cytokine stimulusGO:006076120.011
cytoskeleton organizationGO:0007010960.011
signal transductionGO:00071654550.011
Human Fly
centrosome cycleGO:000709810.011
determination of bilateral symmetryGO:00098552040.011
glycerolipid biosynthetic processGO:004501710.011
spermatid developmentGO:000728620.011
negative regulation of defense responseGO:003134820.011
multi organism reproductive processGO:0044703360.011
cell matrix adhesionGO:000716040.011
locomotory behaviorGO:0007626340.011
determination of heart left right asymmetryGO:00613711170.011
gland developmentGO:00487321430.011
digestive tract morphogenesisGO:00485462310.011
cartilage developmentGO:0051216960.011
positive regulation of cell communicationGO:0010647560.011
Fly
regulation of microtubule cytoskeleton organizationGO:007050730.011
regulation of neuron differentiationGO:0045664560.011
gastrulationGO:00073692080.011
regulation of protein import into nucleusGO:004230620.011
response to nicotineGO:003509420.011
developmental growth involved in morphogenesisGO:0060560860.011
cellular response to endogenous stimulusGO:0071495680.011
Fly
regulation of mrna processingGO:005068430.011
regulation of cellular component movementGO:0051270550.011
positive regulation of cellular processGO:00485222010.011
Fly
regulation of locomotionGO:0040012550.011
regulation of nucleoside metabolic processGO:000911820.011
regulation of nucleocytoplasmic transportGO:004682220.011
response to nutrientGO:000758430.011
response to glucoseGO:000974930.011
muscle cell migrationGO:001481240.011
nucleobase containing compound transportGO:001593120.011
sensory organ morphogenesisGO:00905962000.011
response to woundingGO:00096111160.011
skeletal system morphogenesisGO:00487051020.011
regulation of bone mineralizationGO:003050020.011
peptidyl serine modificationGO:001820920.011
negative regulation of signalingGO:0023057960.010
Fly
oogenesisGO:0048477140.010
dna templated transcription elongationGO:000635430.010
heterocycle biosynthetic processGO:00181302150.010
synaptic vesicle endocytosisGO:004848810.010
embryonic heart tube morphogenesisGO:00031431080.010
regulation of protein localization to nucleusGO:190018020.010
regulation of macromolecule biosynthetic processGO:00105562250.010
negative regulation of protein transportGO:005122430.010
regulation of inflammatory responseGO:005072720.010
response to hormoneGO:0009725480.010
Fly
axon regenerationGO:0031103140.010
cellular response to oxygen levelsGO:007145310.010
negative chemotaxisGO:005091910.010
negative regulation of multi organism processGO:004390130.010
wnt signaling pathwayGO:0016055800.010
b cell activationGO:004211320.010
protein localization to vacuoleGO:007266510.010
sexual reproductionGO:0019953360.010

map4k5 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.030
nervous system diseaseDOID:86300.019
musculoskeletal system diseaseDOID:1700.019
muscular diseaseDOID:008000000.019
muscle tissue diseaseDOID:6600.019
myopathyDOID:42300.019
disease of cellular proliferationDOID:1456600.017
cancerDOID:16200.017
disease of metabolismDOID:001466700.013
immune system diseaseDOID:291400.011