Danio rerio

25 known processes

ctsd

cathepsin D

(Aliases: fj17b09,fb93e11,wu:fj17b09,catD,wu:fb93e11)

ctsd biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
cellular protein catabolic processGO:004425740.431
Yeast
response to external stimulusGO:00096052640.286
regulation of metabolic processGO:00192223590.252
proteolysis involved in cellular protein catabolic processGO:005160330.251
Yeast
defense response to bacteriumGO:0042742220.245
Fly
negative regulation of cellular processGO:00485232830.207
immune system processGO:00023762410.195
regulation of cellular metabolic processGO:00313233200.188
autophagyGO:000691440.181
Yeast Rat
cellular macromolecule metabolic processGO:00442603910.180
Yeast
neuron differentiationGO:00301823530.161
cellular response to nutrient levelsGO:003166920.157
Yeast
positive regulation of transportGO:005105020.155
response to woundingGO:00096111160.145
response to other organismGO:0051707970.141
agingGO:000756820.127
larval developmentGO:000216420.123
ganglioside metabolic processGO:000157330.123
signal transductionGO:00071654550.120
negative regulation of biological processGO:00485193040.116
positive regulation of stress activated protein kinase signaling cascadeGO:007030430.115
regulation of epithelial cell proliferationGO:005067830.113
lipid catabolic processGO:001604240.109
protein metabolic processGO:00195381830.108
Yeast Rat
positive regulation of catabolic processGO:000989640.100
generation of neuronsGO:00486993850.099
single organism metabolic processGO:00447102170.097
Yeast
collagen metabolic processGO:003296320.096
organelle organizationGO:00069962270.095
organic cyclic compound metabolic processGO:19013603010.092
establishment of synaptic vesicle localizationGO:009748010.091
response to external biotic stimulusGO:0043207970.091
regulation of protein catabolic processGO:004217610.089
meiotic chromosome segregationGO:004513230.087
neuron developmentGO:00486662620.084
cellular response to starvationGO:000926710.082
Yeast
wound healingGO:0042060900.081
response to inorganic substanceGO:0010035380.077
response to glucocorticoidGO:005138410.077
tissue remodelingGO:004877140.076
neuron projection developmentGO:00311751800.076
embryo development ending in birth or egg hatchingGO:00097922710.075
homeostatic processGO:00425921420.074
ubiquitin dependent protein catabolic processGO:000651130.073
regulation of multicellular organismal processGO:00512392770.072
cellular response to external stimulusGO:007149620.069
Yeast
positive regulation of cellular catabolic processGO:003133130.067
tissue regenerationGO:0042246740.066
hematopoietic or lymphoid organ developmentGO:00485341910.066
transportGO:00068102200.063
extrinsic apoptotic signaling pathwayGO:009719130.063
maintenance of locationGO:005123540.063
immune system developmentGO:00025201910.062
positive regulation of jnk cascadeGO:004633030.061
myeloid cell differentiationGO:0030099860.059
cellular response to molecule of bacterial originGO:007121930.059
organelle fusionGO:004828430.059
negative regulation of epithelial cell proliferationGO:005068010.058
response to corticosteroidGO:003196010.057
modification dependent protein catabolic processGO:001994130.057
negative regulation of cell deathGO:0060548600.056
cellular protein metabolic processGO:00442671290.056
Yeast
secondary metabolic processGO:001974830.055
cellular response to xenobiotic stimulusGO:0071466350.054
synaptic vesicle localizationGO:009747910.054
cellular nitrogen compound metabolic processGO:00346412900.054
biosynthetic processGO:00090582940.052
small molecule metabolic processGO:0044281770.052
cellular catabolic processGO:0044248270.051
Yeast Rat
regulation of cytokine productionGO:000181730.051
defense responseGO:0006952470.051
Fly
regulation of bindingGO:005109830.050
vacuole organizationGO:000703390.050
single organism membrane fusionGO:004480120.049
cellular pigmentationGO:0033059300.049
regulation of inflammatory responseGO:005072720.047
establishment of organelle localizationGO:0051656450.046
establishment of protein localization to organelleGO:007259440.046
regulation of cell communicationGO:00106462320.046
regulation of oxidative stress induced cell deathGO:190320120.046
urogenital system developmentGO:0001655970.045
embryonic limb morphogenesisGO:003032620.045
tube morphogenesisGO:00352393490.045
regulation of protein modification by small protein conjugation or removalGO:190332030.045
regulation of transcription dna templatedGO:00063552130.045
gland developmentGO:00487321430.045
Fly
synaptic vesicle transportGO:004848910.044
regenerationGO:0031099910.043
proteasome mediated ubiquitin dependent protein catabolic processGO:004316120.043
cell projection morphogenesisGO:00488582440.043
cellular response to extracellular stimulusGO:003166820.042
Yeast
axon developmentGO:00615641660.042
response to antibioticGO:004667710.041
positive regulation of cell cycleGO:004578730.041
neurotransmitter transportGO:000683620.041
lipid storageGO:001991510.041
protein targeting to nucleusGO:004474430.041
regulation of response to oxidative stressGO:190288220.041
peptide metabolic processGO:000651810.041
response to bacteriumGO:0009617580.040
regulation of macromolecule metabolic processGO:00602553170.040
regulation of multicellular organism growthGO:004001440.040
nitrogen compound metabolic processGO:00068073190.040
positive regulation of signal transductionGO:0009967560.040
hemopoiesisGO:00300971830.039
positive regulation of i kappab kinase nf kappab signalingGO:004312330.039
membrane lipid biosynthetic processGO:004646720.038
regulation of apoptotic processGO:0042981980.038
nerve developmentGO:0021675450.038
regulation of protein targetingGO:190353320.038
membrane fusionGO:006102520.038
response to drugGO:004249330.038
cellular response to stressGO:0033554620.037
Yeast
lipid metabolic processGO:0006629520.037
positive regulation of secretion by cellGO:190353210.037
heterocycle metabolic processGO:00464832900.037
cell deathGO:00082191210.036
Fly
single organism localizationGO:19025782250.036
guanosine containing compound metabolic processGO:190106840.035
regulation of biological qualityGO:00650082630.035
positive regulation of stress activated mapk cascadeGO:003287430.035
positive regulation of cellular processGO:00485222010.035
centrosome cycleGO:000709810.035
multicellular organism growthGO:003526440.035
heterocycle biosynthetic processGO:00181302150.034
microtubule organizing center organizationGO:003102310.034
appendage developmentGO:0048736800.034
ceramide biosynthetic processGO:004651310.034
cell part morphogenesisGO:00329902460.034
catabolic processGO:0009056320.033
Yeast Rat
xenobiotic metabolic processGO:000680540.033
embryonic organ developmentGO:00485683810.033
negative regulation of response to stimulusGO:00485851040.033
hepaticobiliary system developmentGO:0061008980.033
multi organism processGO:00517041340.032
defense response to other organismGO:0098542330.032
Fly
melanin metabolic processGO:000658220.032
negative regulation of protein phosphorylationGO:000193340.032
neurotransmitter secretionGO:000726920.031
cellular response to biotic stimulusGO:007121630.031
proteolysisGO:0006508380.031
Yeast Rat
retina development in camera type eyeGO:00600411460.031
vesicle localizationGO:0051648270.031
response to abiotic stimulusGO:00096281220.030
macromolecule biosynthetic processGO:00090592270.030
protein complex localizationGO:003150310.030
amine metabolic processGO:000930820.029
meiotic nuclear divisionGO:000712640.029
negative regulation of programmed cell deathGO:0043069580.029
pigment granule organizationGO:004875340.029
regulation of gene expressionGO:00104682650.029
lipoprotein catabolic processGO:004215910.029
positive regulation of biological processGO:00485182530.029
immune responseGO:0006955280.028
programmed cell deathGO:00125011190.028
Fly
cell proliferationGO:0008283800.028
determination of left right symmetryGO:00073681790.028
cellular nitrogen compound biosynthetic processGO:00442712180.028
regulation of cell shapeGO:000836010.028
response to glucoseGO:000974930.027
immune effector processGO:0002252230.027
proteasomal protein catabolic processGO:001049820.027
sphingolipid biosynthetic processGO:003014820.027
epithelial cell differentiationGO:00308551160.027
cell projection organizationGO:00300302840.027
positive regulation of apoptotic signaling pathwayGO:200123510.027
regulation of protein metabolic processGO:0051246560.026
determination of bilateral symmetryGO:00098552040.026
response to chemicalGO:00422213200.026
system processGO:00030081850.026
guanosine containing compound catabolic processGO:190106920.025
response to monosaccharideGO:003428430.025
growthGO:00400071740.025
negative regulation of sequence specific dna binding transcription factor activityGO:004343320.025
protein importGO:001703830.025
cytoskeleton dependent cytokinesisGO:006164030.025
gtp metabolic processGO:004603940.025
regulation of cell deathGO:00109411030.025
positive regulation of extrinsic apoptotic signaling pathwayGO:200123810.025
positive regulation of exocytosisGO:004592110.025
cellular amine metabolic processGO:004410620.025
regulation of extrinsic apoptotic signaling pathwayGO:200123630.025
positive regulation of secretionGO:005104710.024
cellular response to topologically incorrect proteinGO:003596720.024
mitochondrion organizationGO:000700540.024
purine ribonucleoside monophosphate catabolic processGO:000916940.024
protein import into nucleusGO:000660630.024
negative regulation of nuclear divisionGO:005178430.024
neuroblast proliferationGO:000740520.024
regulation of establishment of protein localizationGO:007020140.024
positive regulation of metabolic processGO:00098931080.024
camera type eye developmentGO:00430102220.023
nuclear transportGO:005116940.023
regulation of signalingGO:00230512350.023
regulation of primary metabolic processGO:00800903110.023
heart morphogenesisGO:00030071560.023
stem cell proliferationGO:007208940.023
neuron projection morphogenesisGO:00488121610.023
defense response to gram positive bacteriumGO:005083060.023
positive regulation of protein complex assemblyGO:003133420.023
regulation of cellular phGO:003064110.023
protein targeting to vacuoleGO:000662310.023
response to oxygen levelsGO:0070482250.023
embryonic skeletal system developmentGO:0048706970.023
embryonic organ morphogenesisGO:00485622740.023
response to stressGO:00069502630.023
Yeast Fly
negative regulation of protein kinase activityGO:000646940.023
mitotic cell cycleGO:0000278640.023
response to hexoseGO:000974630.023
innate immune responseGO:0045087130.023
nucleocytoplasmic transportGO:000691340.023
morphogenesis of an epitheliumGO:00020093330.023
macroautophagyGO:001623610.022
protein ubiquitination involved in ubiquitin dependent protein catabolic processGO:004278710.022
positive regulation of cytokine productionGO:000181920.022
renal system developmentGO:0072001940.022
cell morphogenesisGO:00009022890.022
erythrocyte homeostasisGO:0034101550.022
fin regenerationGO:0031101510.022
zymogen activationGO:003163830.022
negative regulation of kinase activityGO:003367340.021
ph reductionGO:004585110.021
single organism nuclear importGO:190259330.021
negative regulation of sequestering of calcium ionGO:005128340.021
regulation of programmed cell deathGO:00430671010.021
regulation of synaptic vesicle transportGO:190280310.021
phagocytosisGO:000690930.021
meiotic cell cycle processGO:190304630.021
embryonic heart tube morphogenesisGO:00031431080.021
establishment of localizationGO:00512342440.021
regulation of proteolysis involved in cellular protein catabolic processGO:190305010.021
organic acid metabolic processGO:0006082310.021
peptidyl serine phosphorylationGO:001810510.021
regulation of protein complex assemblyGO:004325430.021
regulation of protein import into nucleusGO:004230620.021
epithelial tube morphogenesisGO:00605621480.021
single organism membrane organizationGO:0044802200.021
Yeast
pigmentationGO:0043473850.021
response to carbohydrateGO:000974330.020
regulation of protein ubiquitinationGO:003139630.020
cofactor metabolic processGO:0051186150.020
nuclear importGO:005117030.020
defense response to gram negative bacteriumGO:005082980.020
Fly
positive regulation of neuron deathGO:190121610.020
response to hypoxiaGO:0001666250.020
cilium assemblyGO:0042384580.020
response to xenobiotic stimulusGO:0009410450.020
regulation of cellular protein catabolic processGO:190336210.020
positive regulation of cellular amine metabolic processGO:003324000.019
cellular biosynthetic processGO:00442492860.019
regulation of autophagyGO:001050630.019
negative regulation of protein serine threonine kinase activityGO:007190120.019
rna localizationGO:000640340.019
centrosome organizationGO:005129710.019
response to hydrogen peroxideGO:004254230.019
regulation of dendrite morphogenesisGO:004881430.019
response to uvGO:000941130.019
spermatid differentiationGO:004851520.019
regulation of intracellular protein transportGO:003315730.019
renal tubule morphogenesisGO:006133310.019
sialylationGO:009750340.019
developmental growthGO:00485891660.019
regulation of metal ion transportGO:001095940.019
cytokinetic processGO:003250620.019
rrna catabolic processGO:001607510.019
cellular amino acid metabolic processGO:000652070.018
regulation of nucleic acid templated transcriptionGO:19035062130.018
eye developmentGO:00016542770.018
kidney developmentGO:0001822920.018
single organism organelle organizationGO:19025891990.018
nucleic acid templated transcriptionGO:00976591810.018
myeloid cell homeostasisGO:0002262560.018
ion homeostasisGO:0050801410.018
oxoacid metabolic processGO:0043436310.018
peptidyl serine modificationGO:001820920.018
angiogenesisGO:00015251580.018
ncrna catabolic processGO:003466110.018
establishment of rna localizationGO:005123630.018
cellular homeostasisGO:0019725260.017
positive regulation of dna metabolic processGO:005105410.017
cellular macromolecule catabolic processGO:0044265120.017
Yeast
cellular cation homeostasisGO:0030003170.017
compound eye developmentGO:004874920.017
cellular chemical homeostasisGO:0055082170.017
multicellular organismal macromolecule metabolic processGO:004425920.017
b cell activationGO:004211320.017
cellular amide metabolic processGO:004360340.017
purine nucleoside monophosphate catabolic processGO:000912840.017
regulation of cell activationGO:005086510.017
positive regulation of cellular component biogenesisGO:004408930.017
gtp catabolic processGO:000618420.017
cellular macromolecule biosynthetic processGO:00346452240.017
sequestering of calcium ionGO:005120830.017
liposaccharide metabolic processGO:190350980.017
sensory perception of touchGO:005097520.017
b cell differentiationGO:003018310.017
regulation of cellular amine metabolic processGO:003323800.017
gamete generationGO:0007276330.016
Fly
regulation of protein transportGO:005122330.016
regulation of cell morphogenesis involved in differentiationGO:0010769380.016
regulation of synaptic growth at neuromuscular junctionGO:000858210.016
blood vessel developmentGO:00015682460.016
protein localization to nucleusGO:003450430.016
positive regulation of epithelial cell proliferationGO:005067910.016
positive regulation of neuron apoptotic processGO:004352510.016
phosphate containing compound metabolic processGO:00067961080.016
cilium organizationGO:0044782710.016
extrinsic apoptotic signaling pathway via death domain receptorsGO:000862510.016
myeloid cell developmentGO:0061515320.016
specification of symmetryGO:00097992040.016
gene expressionGO:00104672520.016
organic substance catabolic processGO:1901575280.016
Yeast
cellular response to chemical stimulusGO:00708871570.016
nucleobase containing compound biosynthetic processGO:00346542050.016
cellular response to lipopolysaccharideGO:007122230.016
regulation of i kappab kinase nf kappab signalingGO:004312240.016
vasculature developmentGO:00019442780.016
determination of heart left right asymmetryGO:00613711170.015
nephron epithelium morphogenesisGO:007208810.015
regulation of cytoplasmic transportGO:190364940.015
endosomal transportGO:001619720.015
erythrocyte differentiationGO:0030218540.015
liver developmentGO:0001889960.015
regulation of phGO:000688530.015
regulation of neural precursor cell proliferationGO:200017730.015
small molecule catabolic processGO:004428230.015
positive regulation of immune effector processGO:000269930.015
alcohol biosynthetic processGO:004616520.015
symbiosis encompassing mutualism through parasitismGO:004440340.015
heart loopingGO:0001947940.015
axonogenesisGO:00074091520.015
positive regulation of cellular metabolic processGO:0031325940.015
cellular lipid metabolic processGO:0044255360.014
cellular protein modification processGO:00064641000.014
regulation of dendrite developmentGO:005077330.014
nucleobase containing compound metabolic processGO:00061392740.014
organic cyclic compound biosynthetic processGO:19013622230.014
stem cell divisionGO:001714510.014
modification dependent macromolecule catabolic processGO:004363230.014
skeletal system developmentGO:00015011810.014
regulation of cellular amino acid metabolic processGO:000652100.014
regulation of protein bindingGO:004339330.014
homeostasis of number of cellsGO:0048872620.014
regulation of cellular biosynthetic processGO:00313262450.014
rna transportGO:005065820.014
response to nutrientGO:000758430.014
regulation of response to stressGO:0080134360.014
multi organism reproductive processGO:0044703360.014
Fly
peptide transportGO:001583310.014
positive regulation of cell activationGO:005086710.014
spindle assembly involved in mitosisGO:009030710.014
regulation of multicellular organismal developmentGO:20000262230.013
regulation of phosphorus metabolic processGO:0051174430.013
regulation of transmembrane receptor protein serine threonine kinase signaling pathwayGO:0090092500.013
single organism transportGO:00447652060.013
transcription dna templatedGO:00063511810.013
negative regulation of cytokine productionGO:000181810.013
positive regulation of notch signaling pathwayGO:004574730.013
regulation of exocytosisGO:001715710.013
response to organic substanceGO:00100331530.013
regulation of cell differentiationGO:00455951420.013
cellular aromatic compound metabolic processGO:00067252950.013
negative regulation of intracellular transportGO:003238730.013
cellular monovalent inorganic cation homeostasisGO:003000420.013
notochord developmentGO:0030903540.013
organonitrogen compound metabolic processGO:1901564740.013
regulation of wound healingGO:006104120.013
negative regulation of apoptotic processGO:0043066550.013
pigment metabolic processGO:0042440120.013
wnt signaling pathwayGO:0016055800.013
regulation of mitochondrion organizationGO:001082110.013
nucleic acid metabolic processGO:00903042440.013
regulation of synapse organizationGO:005080730.013
protein homooligomerizationGO:005126030.013
neural tube patterningGO:0021532330.013
notochord cell developmentGO:006003590.013
regulation of response to nutrient levelsGO:003210710.013
response to decreased oxygen levelsGO:0036293250.013
cellular response to reactive oxygen speciesGO:003461420.013
negative regulation of cell communicationGO:0010648960.013
ribonucleoside monophosphate catabolic processGO:000915840.013
i kappab kinase nf kappab signalingGO:000724940.013
lymphocyte proliferationGO:004665110.013
cytoskeleton organizationGO:0007010960.013
protein secretionGO:000930610.012
regulation of microtubule cytoskeleton organizationGO:007050730.012
trabecula formationGO:006034320.012
regulation of stem cell proliferationGO:007209120.012
organonitrogen compound biosynthetic processGO:1901566470.012
protein n linked glycosylationGO:000648710.012
g1 s transition of mitotic cell cycleGO:000008210.012
bone remodelingGO:004684920.012
apoptotic processGO:00069151160.012
Fly
positive regulation of immune system processGO:0002684170.012
rna metabolic processGO:00160702190.012
cellular response to fatty acidGO:007139830.012
establishment of vesicle localizationGO:0051650240.012
regulation of cellular component movementGO:0051270550.012
head developmentGO:00603223030.012
regulation of developmental processGO:00507932470.012
epithelial cell proliferation involved in liver morphogenesisGO:007257520.012
sequestering of metal ionGO:005123830.012
blood circulationGO:0008015870.012
phagocytosis engulfmentGO:000691110.012
cilium morphogenesisGO:0060271850.012
positive regulation of jun kinase activityGO:004350720.012
regulation of neuron projection developmentGO:0010975400.012
carbohydrate derivative metabolic processGO:1901135610.012
phosphorylationGO:0016310690.012
response to copper ionGO:0046688130.012
regulation of signal transductionGO:00099662250.012
melanosome organizationGO:003243840.012
post embryonic morphogenesisGO:000988640.012
Fly
negative regulation of nucleocytoplasmic transportGO:004682320.012
response to topologically incorrect proteinGO:003596620.012
regulation of response to extracellular stimulusGO:003210410.012
spermatid developmentGO:000728620.012
macromolecule deacylationGO:009873230.011
regulation of receptor mediated endocytosisGO:004825940.011
regulation of synaptic plasticityGO:004816710.011
erk1 and erk2 cascadeGO:007037140.011
alpha amino acid metabolic processGO:190160530.011
regulation of receptor activityGO:001046920.011
digestive tract morphogenesisGO:00485462310.011
meiotic spindle organizationGO:000021210.011
response to fatty acidGO:007054250.011
response to nutrient levelsGO:0031667100.011
Yeast
lytic vacuole organizationGO:008017110.011
gastrulation with mouth forming secondGO:0001702440.011
regulation of calcium ion transportGO:005192420.011
dna templated transcription initiationGO:000635210.011
regulation of cellular ketone metabolic processGO:001056570.011
regulation of neurotransmitter secretionGO:004692810.011
regulation of protein localization to nucleusGO:190018020.011
mitotic cell cycle embryonicGO:004544820.011
vacuolar transportGO:000703420.011
interspecies interaction between organismsGO:004441940.011
regulation of chromosome segregationGO:005198310.011
negative regulation of protein complex assemblyGO:003133310.011
cell fate specificationGO:0001708680.011
protein polymerizationGO:005125840.011
regulation of organ growthGO:004662030.011
synaptic growth at neuromuscular junctionGO:005112420.011
positive regulation of leukocyte differentiationGO:190210710.010
regulation of reproductive processGO:200024140.010
regulation of sequestering of calcium ionGO:005128240.010
cell cycle arrestGO:000705010.010
reactive nitrogen species metabolic processGO:200105700.010
neuromuscular synaptic transmissionGO:000727420.010
response to unfolded proteinGO:000698620.010
negative regulation of multicellular organismal processGO:0051241690.010
spindle assemblyGO:005122520.010
intracellular signal transductionGO:0035556850.010
negative regulation of intracellular protein transportGO:009031730.010
brain developmentGO:00074202930.010
positive regulation of nucleoside metabolic processGO:004597910.010
enzyme linked receptor protein signaling pathwayGO:00071671060.010
cellular component morphogenesisGO:00329893360.010
regulation of neurogenesisGO:0050767870.010
protein localization to cell surfaceGO:003439430.010

ctsd disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of metabolismDOID:001466700.098
Human
lysosomal storage diseaseDOID:321100.098
Human
lipid storage diseaseDOID:945500.098
Human
inherited metabolic disorderDOID:65500.098
Human
disease of anatomical entityDOID:700.050
nervous system diseaseDOID:86300.033
organ system cancerDOID:005068600.014
cancerDOID:16200.014
disease of cellular proliferationDOID:1456600.014
intestinal cancerDOID:1015500.014
gastrointestinal system cancerDOID:311900.014
large intestine cancerDOID:567200.014
colon carcinomaDOID:152000.014
colorectal cancerDOID:925600.014
colon cancerDOID:21900.014
musculoskeletal system diseaseDOID:1700.012
tauopathyDOID:68000.011
neurodegenerative diseaseDOID:128900.011
central nervous system diseaseDOID:33100.011