Danio rerio

24 known processes

keap1a

kelch-like ECH-associated protein 1a

(Aliases: keap1,fb36f11,MGC136521,wu:fb36f11)

keap1a biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
nucleic acid metabolic processGO:00903042440.382
gene expressionGO:00104672520.280
nucleobase containing compound metabolic processGO:00061392740.272
heterocycle metabolic processGO:00464832900.239
cellular nitrogen compound biosynthetic processGO:00442712180.218
macromolecule biosynthetic processGO:00090592270.209
regulation of gene expressionGO:00104682650.204
cellular biosynthetic processGO:00442492860.198
organic substance biosynthetic processGO:19015762890.197
heterocycle biosynthetic processGO:00181302150.190
nucleobase containing compound biosynthetic processGO:00346542050.185
aromatic compound biosynthetic processGO:00194382170.165
organic cyclic compound biosynthetic processGO:19013622230.164
cellular nitrogen compound metabolic processGO:00346412900.157
nucleic acid templated transcriptionGO:00976591810.155
response to xenobiotic stimulusGO:0009410450.153
rna metabolic processGO:00160702190.144
response to inorganic substanceGO:0010035380.143
regulation of rna biosynthetic processGO:20011412130.141
organic cyclic compound metabolic processGO:19013603010.138
cellular macromolecule biosynthetic processGO:00346452240.125
cellular aromatic compound metabolic processGO:00067252950.119
blood vessel morphogenesisGO:00485142160.118
nitrogen compound metabolic processGO:00068073190.117
multicellular organism growthGO:003526440.110
regulation of nitrogen compound metabolic processGO:00511712510.110
regulation of cellular biosynthetic processGO:00313262450.109
regulation of transcription dna templatedGO:00063552130.095
biosynthetic processGO:00090582940.094
transcription dna templatedGO:00063511810.093
cellular macromolecule metabolic processGO:00442603910.091
regulation of multicellular organism growthGO:004001440.083
response to chemicalGO:00422213200.081
establishment of localizationGO:00512342440.079
rna biosynthetic processGO:00327741810.079
regulation of rna metabolic processGO:00512522240.079
regulation of macromolecule metabolic processGO:00602553170.074
regulation of response to oxidative stressGO:190288220.070
regulation of cellular macromolecule biosynthetic processGO:20001122220.070
single organism transportGO:00447652060.069
regulation of nucleobase containing compound metabolic processGO:00192192500.068
response to metal ionGO:0010038340.068
response to fatty acidGO:007054250.067
regulation of i kappab kinase nf kappab signalingGO:004312240.066
immune system processGO:00023762410.065
liver developmentGO:0001889960.064
Zebrafish
signal transductionGO:00071654550.063
vasculature developmentGO:00019442780.061
larval developmentGO:000216420.061
ion transmembrane transportGO:0034220910.061
response to hormoneGO:0009725480.060
regulation of biosynthetic processGO:00098892500.060
transcription from rna polymerase ii promoterGO:0006366800.059
erythrocyte homeostasisGO:0034101550.058
regulation of metabolic processGO:00192223590.057
cellular response to chemical stimulusGO:00708871570.055
innate immune responseGO:0045087130.054
cellular response to xenobiotic stimulusGO:0071466350.054
response to external stimulusGO:00096052640.054
maintenance of locationGO:005123540.053
regulation of cytokine productionGO:000181730.051
response to endogenous stimulusGO:0009719830.051
angiogenesisGO:00015251580.051
regulation of primary metabolic processGO:00800903110.050
regulation of macromolecule biosynthetic processGO:00105562250.050
regulation of establishment of protein localizationGO:007020140.049
positive regulation of cellular component biogenesisGO:004408930.049
regulation of protein transportGO:005122330.048
regulation of cellular metabolic processGO:00313233200.048
response to glucocorticoidGO:005138410.048
regulation of cellular amine metabolic processGO:003323800.046
positive regulation of cellular processGO:00485222010.046
agingGO:000756820.046
regulation of wound healingGO:006104120.046
embryonic organ developmentGO:00485683810.045
response to stressGO:00069502630.045
regulation of cellular response to oxidative stressGO:190040720.044
response to woundingGO:00096111160.044
reactive oxygen species metabolic processGO:007259360.043
cellular ketone metabolic processGO:0042180110.042
positive regulation of macromolecule metabolic processGO:0010604930.042
regulation of nucleic acid templated transcriptionGO:19035062130.041
ion transportGO:00068111140.041
regulation of multicellular organismal processGO:00512392770.041
defense responseGO:0006952470.040
carboxylic acid metabolic processGO:0019752220.040
locomotionGO:00400113130.039
superoxide metabolic processGO:000680120.039
muscle tissue developmentGO:00605371100.039
response to nutrientGO:000758430.038
lipid storageGO:001991510.038
response to oxygen containing compoundGO:1901700550.037
protein secretionGO:000930610.037
positive regulation of cellular metabolic processGO:0031325940.037
positive regulation of cytokine productionGO:000181920.037
cation transportGO:0006812810.037
extrinsic apoptotic signaling pathwayGO:009719130.035
peptidyl serine phosphorylationGO:001810510.035
cellular amine metabolic processGO:004410620.035
positive regulation of transportGO:005105020.035
regulation of transcription from rna polymerase ii promoterGO:00063571140.035
endoplasmic reticulum unfolded protein responseGO:003096820.035
response to biotic stimulusGO:0009607970.035
regulation of inflammatory responseGO:005072720.034
response to alkaloidGO:004327920.034
response to other organismGO:0051707970.033
tissue remodelingGO:004877140.033
inorganic ion transmembrane transportGO:0098660570.033
positive regulation of cellular catabolic processGO:003133130.033
regulation of biological qualityGO:00650082630.033
secondary metabolic processGO:001974830.032
mitochondrion organizationGO:000700540.032
regulation of developmental processGO:00507932470.031
p38mapk cascadeGO:003806610.031
single organism localizationGO:19025782250.031
lymphocyte homeostasisGO:000226010.031
positive regulation of endothelial cell proliferationGO:000193810.030
positive regulation of catabolic processGO:000989640.030
positive regulation of nucleic acid templated transcriptionGO:1903508570.030
cellular response to hormone stimulusGO:0032870390.030
cellular response to topologically incorrect proteinGO:003596720.029
multi organism processGO:00517041340.029
positive regulation of wound healingGO:009030310.029
blood vessel developmentGO:00015682460.028
response to oxygen radicalGO:000030520.028
chordate embryonic developmentGO:00430092710.027
organonitrogen compound metabolic processGO:1901564740.027
sensory organ morphogenesisGO:00905962000.027
insulin like growth factor receptor signaling pathwayGO:004800940.027
guanosine containing compound metabolic processGO:190106840.027
erythrocyte differentiationGO:0030218540.027
response to bacteriumGO:0009617580.027
homeostatic processGO:00425921420.026
cellular component morphogenesisGO:00329893360.026
response to lipidGO:0033993600.026
positive regulation of neuron deathGO:190121610.026
somitogenesisGO:0001756870.026
positive regulation of cellular amino acid metabolic processGO:004576400.026
adult behaviorGO:003053420.025
regulation of reactive oxygen species metabolic processGO:200037720.025
regulation of tube sizeGO:003515020.025
developmental programmed cell deathGO:001062340.025
regulation of cellular amino acid metabolic processGO:000652100.025
regionalizationGO:00030022740.025
purine ribonucleoside biosynthetic processGO:004612920.025
ovulation cycleGO:004269820.025
internal peptidyl lysine acetylationGO:001839320.025
cell death in response to oxidative stressGO:003647320.025
myeloid cell homeostasisGO:0002262560.024
positive regulation of biological processGO:00485182530.024
amine metabolic processGO:000930820.024
response to topologically incorrect proteinGO:003596620.024
purine ribonucleoside monophosphate catabolic processGO:000916940.024
regulation of proteolysis involved in cellular protein catabolic processGO:190305010.024
hindbrain developmentGO:0030902910.024
apoptotic process involved in developmentGO:190274220.024
cellular response to prostaglandin stimulusGO:007137930.024
inorganic cation transmembrane transportGO:0098662500.023
single organism metabolic processGO:00447102170.023
transmembrane transportGO:00550851200.023
response to copper ionGO:0046688130.023
positive regulation of response to woundingGO:190303650.023
organic acid metabolic processGO:0006082310.023
regulation of circadian rhythmGO:004275240.023
cellular amino acid metabolic processGO:000652070.023
female gonad developmentGO:000858540.023
regulation of cell activationGO:005086510.023
leukocyte homeostasisGO:000177620.022
immune system developmentGO:00025201910.022
negative regulation of metabolic processGO:0009892860.022
positive regulation of rna metabolic processGO:0051254590.022
embryo development ending in birth or egg hatchingGO:00097922710.022
positive regulation of transcription dna templatedGO:0045893570.022
cellular response to biotic stimulusGO:007121630.022
hatchingGO:003518840.022
removal of superoxide radicalsGO:001943020.022
monovalent inorganic cation transportGO:0015672420.021
response to unfolded proteinGO:000698620.021
peptidyl serine modificationGO:001820920.021
response to external biotic stimulusGO:0043207970.021
defense response to bacteriumGO:0042742220.021
sensory organ developmentGO:00074233930.021
extrinsic apoptotic signaling pathway via death domain receptorsGO:000862510.021
regulation of protein modification by small protein conjugation or removalGO:190332030.021
response to transition metal nanoparticleGO:1990267280.021
i kappab kinase nf kappab signalingGO:000724940.020
gland developmentGO:00487321430.020
Zebrafish
regulation of oxidative stress induced cell deathGO:190320120.020
epithelial cell differentiationGO:00308551160.020
homeostasis of number of cellsGO:0048872620.020
regulation of cellular ketone metabolic processGO:001056570.020
modification dependent protein catabolic processGO:001994130.020
camera type eye developmentGO:00430102220.020
enzyme linked receptor protein signaling pathwayGO:00071671060.020
regulation of protein catabolic processGO:004217610.020
positive regulation of cellular biosynthetic processGO:0031328680.019
oxoacid metabolic processGO:0043436310.019
regulation of p38mapk cascadeGO:190074410.019
positive regulation of stem cell proliferationGO:200064810.019
single organism biosynthetic processGO:0044711710.019
positive regulation of metabolic processGO:00098931080.019
response to carbohydrateGO:000974330.019
protein metabolic processGO:00195381830.019
positive regulation of cellular amine metabolic processGO:003324000.019
regulation of transmembrane receptor protein serine threonine kinase signaling pathwayGO:0090092500.019
modification of morphology or physiology of other organismGO:003582140.019
symbiosis encompassing mutualism through parasitismGO:004440340.019
peptide transportGO:001583310.019
cation transmembrane transportGO:0098655650.018
response to corticosteroidGO:003196010.018
ameboidal type cell migrationGO:00016671430.018
cellular response to oxygen containing compoundGO:1901701200.018
modulation by virus of host morphology or physiologyGO:001904810.018
response to hexoseGO:000974630.018
regulation of protein ubiquitinationGO:003139630.018
cellular response to unfolded proteinGO:003462020.018
regulation of extrinsic apoptotic signaling pathwayGO:200123630.018
cellular response to lipopolysaccharideGO:007122230.018
negative regulation of dna replicationGO:000815620.018
cell surface receptor signaling pathwayGO:00071663250.018
hemopoiesisGO:00300971830.018
response to cadmium ionGO:0046686140.018
killing of cells in other organism involved in symbiotic interactionGO:005188310.018
regulation of response to stressGO:0080134360.018
positive regulation of macromolecule biosynthetic processGO:0010557590.017
cellular response to stressGO:0033554620.017
positive regulation of multicellular organismal processGO:0051240520.017
cellular response to organic substanceGO:00713101050.017
regulation of response to stimulusGO:00485832690.017
response to ketoneGO:190165410.017
hematopoietic or lymphoid organ developmentGO:00485341910.017
response to glucoseGO:000974930.017
cellular response to estradiol stimulusGO:007139210.017
positive regulation of secretionGO:005104710.017
regulation of multicellular organismal developmentGO:20000262230.017
brain developmentGO:00074202930.016
leukocyte proliferationGO:007066110.016
er nucleus signaling pathwayGO:000698420.016
regulation of phGO:000688530.016
positive regulation of inflammatory responseGO:005072910.016
positive regulation of jak stat cascadeGO:004642720.016
female sex differentiationGO:004666040.016
intracellular signal transductionGO:0035556850.016
organelle fusionGO:004828430.016
regulation of cell communicationGO:00106462320.016
regulation of mitochondrion organizationGO:001082110.016
intrinsic apoptotic signaling pathway in response to oxidative stressGO:000863120.016
regulation of protein localization to nucleusGO:190018020.016
transmembrane receptor protein serine threonine kinase signaling pathwayGO:0007178680.016
protein acetylationGO:000647320.016
cellular response to fatty acidGO:007139830.016
post embryonic organ developmentGO:004856940.016
striated muscle tissue developmentGO:00147061100.016
gtp metabolic processGO:004603940.015
positive regulation of secretion by cellGO:190353210.015
small molecule metabolic processGO:0044281770.015
response to amino acidGO:004320020.015
positive regulation of neuron apoptotic processGO:004352510.015
protein acylationGO:004354330.015
cell morphogenesis involved in differentiationGO:00009041950.015
organelle organizationGO:00069962270.015
response to organic substanceGO:00100331530.015
positive regulation of biosynthetic processGO:0009891680.015
peptidyl lysine acetylationGO:001839420.015
positive regulation of immune effector processGO:000269930.015
positive regulation of epithelial cell migrationGO:001063420.015
tube morphogenesisGO:00352393490.015
cellular protein catabolic processGO:004425740.015
cell matrix adhesionGO:000716040.015
regulation of insulin like growth factor receptor signaling pathwayGO:004356710.015
neuron differentiationGO:00301823530.015
regulation of cytokine mediated signaling pathwayGO:000195930.015
myeloid cell differentiationGO:0030099860.015
zymogen activationGO:003163830.015
single organism membrane fusionGO:004480120.015
cellular response to extracellular stimulusGO:003166820.015
negative regulation of dna metabolic processGO:005105340.015
developmental growthGO:00485891660.015
wound healingGO:0042060900.015
positive regulation of cell cycleGO:004578730.015
regulation of blood vessel sizeGO:005088020.014
response to monosaccharideGO:003428430.014
embryonic hemopoiesisGO:0035162530.014
post embryonic organ morphogenesisGO:004856310.014
pyruvate metabolic processGO:000609010.014
regulation of dna replicationGO:000627530.014
sensory perceptionGO:0007600390.014
protein importGO:001703830.014
somite developmentGO:0061053960.014
negative regulation of gene expressionGO:0010629650.014
pigment metabolic processGO:0042440120.014
lipid catabolic processGO:001604240.014
neuromuscular process controlling balanceGO:005088530.014
development of primary female sexual characteristicsGO:004654540.014
carbon dioxide transportGO:001567030.014
myeloid cell developmentGO:0061515320.014
deathGO:00162651210.014
cellular response to lipidGO:0071396390.014
fatty acid biosynthetic processGO:000663340.014
positive regulation of cell activationGO:005086710.014
cell proliferationGO:0008283800.014
cellular protein metabolic processGO:00442671290.013
protein targeting to nucleusGO:004474430.013
cellular component disassemblyGO:002241110.013
cellular component biogenesisGO:00440851780.013
cell projection organizationGO:00300302840.013
positive regulation of dna metabolic processGO:005105410.013
gtp catabolic processGO:000618420.013
epithelium migrationGO:0090132250.013
purine nucleoside triphosphate biosynthetic processGO:000914520.013
protein localization to nucleusGO:003450430.013
cellular response to oxygen radicalGO:007145020.013
negative regulation of biological processGO:00485193040.013
regulation of response to cytokine stimulusGO:006075930.013
negative regulation of extrinsic apoptotic signaling pathwayGO:200123720.013
regulation of cytoplasmic transportGO:190364940.013
regulation of erk1 and erk2 cascadeGO:007037240.013
positive regulation of rna biosynthetic processGO:1902680570.013
positive regulation of protein complex assemblyGO:003133420.013
regulation of protein complex assemblyGO:004325430.013
apoptotic process involved in morphogenesisGO:006056120.013
positive regulation of i kappab kinase nf kappab signalingGO:004312330.013
membrane repolarizationGO:008600920.013
oocyte maturationGO:000155640.013
positive regulation of neural precursor cell proliferationGO:200017910.013
positive regulation of defense responseGO:003134990.013
interaction with hostGO:005170140.013
regulation of epithelial cell proliferationGO:005067830.013
internal protein amino acid acetylationGO:000647520.013
membrane fusionGO:006102520.012
regulation of dendrite developmentGO:005077330.012
oxidative demethylationGO:007098910.012
proteolysis involved in cellular protein catabolic processGO:005160330.012
protein import into nucleusGO:000660630.012
nucleocytoplasmic transportGO:000691340.012
transportGO:00068102200.012
ovulation cycle processGO:002260220.012
alcohol biosynthetic processGO:004616520.012
cell part morphogenesisGO:00329902460.012
proteasome mediated ubiquitin dependent protein catabolic processGO:004316120.012
modification dependent macromolecule catabolic processGO:004363230.012
retina development in camera type eyeGO:00600411460.012
protein localization to plasma membraneGO:007265910.012
positive regulation of nitrogen compound metabolic processGO:0051173690.012
autophagyGO:000691440.012
positive regulation of apoptotic signaling pathwayGO:200123510.012
melanin metabolic processGO:000658220.012
positive regulation of nucleobase containing compound metabolic processGO:0045935690.012
regulation of cell deathGO:00109411030.012
stem cell proliferationGO:007208940.012
type i interferon productionGO:003260620.012
spermatid developmentGO:000728620.012
sex determinationGO:000753010.012
cellular response to reactive oxygen speciesGO:003461420.012
response to vitaminGO:003327330.012
striated muscle cell differentiationGO:00511461290.012
hydrogen peroxide metabolic processGO:004274320.012
positive regulation of gene expressionGO:0010628710.012
single organism organelle organizationGO:19025891990.012
response to uvGO:000941130.012
regulation of gtpase activityGO:004308720.012
regulation of cellular component organizationGO:0051128860.012
tetrapyrrole metabolic processGO:0033013100.011
negative regulation of cytokine productionGO:000181810.011
phagocytosisGO:000690930.011
carboxylic acid biosynthetic processGO:0046394120.011
dorsal ventral pattern formationGO:00099531250.011
cellular response to external stimulusGO:007149620.011
cellular response to radiationGO:007147840.011
central nervous system developmentGO:00074173870.011
negative regulation of apoptotic processGO:0043066550.011
nuclear importGO:005117030.011
regulation of lipid transportGO:003236840.011
cellular response to superoxideGO:007145120.011
response to hydrogen peroxideGO:004254230.011
inner ear developmentGO:00488391260.011
organism emergence from protective structureGO:007168440.011
cell projection morphogenesisGO:00488582440.011
response to drugGO:004249330.011
neurological system processGO:0050877620.011
regulation of nucleotide catabolic processGO:003081120.011
nucleoside biosynthetic processGO:000916320.011
guanosine containing compound catabolic processGO:190106920.011
regulation of response to external stimulusGO:0032101310.011
regulation of oxidative stress induced intrinsic apoptotic signaling pathwayGO:190217520.011
b cell activationGO:004211320.011
dicarboxylic acid transportGO:000683510.011
cell motilityGO:00488702440.011
microtubule cytoskeleton organization involved in mitosisGO:190285010.011
b cell mediated immunityGO:001972430.010
ubiquitin dependent protein catabolic processGO:000651130.010
negative regulation of defense responseGO:003134820.010
regulation of signal transductionGO:00099662250.010
exocytosisGO:000688710.010
regulation of jak stat cascadeGO:004642530.010
hepaticobiliary system developmentGO:0061008980.010
Zebrafish
regulation of neural precursor cell proliferationGO:200017730.010
generation of neuronsGO:00486993850.010
nucleoside triphosphate biosynthetic processGO:000914220.010
negative regulation of macromolecule metabolic processGO:0010605760.010
production of molecular mediator of immune responseGO:000244020.010
regulation of protein targetingGO:190353320.010
regulation of cell projection organizationGO:0031344440.010
system processGO:00030081850.010
programmed cell deathGO:00125011190.010
regulation of sodium ion transportGO:000202820.010

keap1a disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.066
nervous system diseaseDOID:86300.049
inherited metabolic disorderDOID:65500.023
disease of metabolismDOID:001466700.023
organ system cancerDOID:005068600.017
disease of cellular proliferationDOID:1456600.017
cancerDOID:16200.017
neurodegenerative diseaseDOID:128900.016
central nervous system diseaseDOID:33100.016
amyotrophic lateral sclerosisDOID:33200.016
motor neuron diseaseDOID:23100.016
musculoskeletal system diseaseDOID:1700.015
lipid storage diseaseDOID:945500.013
lysosomal storage diseaseDOID:321100.013
immune system diseaseDOID:291400.012
connective tissue diseaseDOID:6500.011