Danio rerio

0 known processes

appl2

adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2

appl2 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
signal transductionGO:00071654550.360
cellular macromolecule metabolic processGO:00442603910.332
cell morphogenesisGO:00009022890.310
regulation of primary metabolic processGO:00800903110.307
morphogenesis of an epitheliumGO:00020093330.270
rna metabolic processGO:00160702190.267
generation of neuronsGO:00486993850.261
regulation of metabolic processGO:00192223590.259
cell surface receptor signaling pathwayGO:00071663250.250
regulation of gene expressionGO:00104682650.248
cellular component morphogenesisGO:00329893360.238
digestive system developmentGO:00551232890.226
digestive tract developmentGO:00485652650.226
neuroblast proliferationGO:000740520.225
tube morphogenesisGO:00352393490.218
cell part morphogenesisGO:00329902460.215
regulation of nitrogen compound metabolic processGO:00511712510.214
cell projection organizationGO:00300302840.210
regulation of macromolecule metabolic processGO:00602553170.209
embryonic heart tube developmentGO:00350501330.200
heart developmentGO:00075073130.196
embryo development ending in birth or egg hatchingGO:00097922710.194
gastrulationGO:00073692080.194
enzyme linked receptor protein signaling pathwayGO:00071671060.193
cellular component movementGO:00069283350.188
regulation of cellular metabolic processGO:00313233200.187
regulation of epithelial cell proliferationGO:005067830.187
regulation of macromolecule biosynthetic processGO:00105562250.185
regulation of rna metabolic processGO:00512522240.180
cell projection morphogenesisGO:00488582440.178
regulation of synapse organizationGO:005080730.178
central nervous system developmentGO:00074173870.174
heterocycle metabolic processGO:00464832900.171
cellular macromolecule biosynthetic processGO:00346452240.167
regulation of nucleobase containing compound metabolic processGO:00192192500.164
nucleic acid metabolic processGO:00903042440.158
organic cyclic compound metabolic processGO:19013603010.158
cellular nitrogen compound biosynthetic processGO:00442712180.149
locomotionGO:00400113130.147
stem cell proliferationGO:007208940.146
cell morphogenesis involved in differentiationGO:00009041950.146
negative regulation of biological processGO:00485193040.145
cellular aromatic compound metabolic processGO:00067252950.142
eye developmentGO:00016542770.142
response to chemicalGO:00422213200.137
nucleobase containing compound metabolic processGO:00061392740.135
aromatic compound biosynthetic processGO:00194382170.133
cell fate commitmentGO:0045165990.130
regulation of rna biosynthetic processGO:20011412130.129
specification of symmetryGO:00097992040.126
neuron differentiationGO:00301823530.126
gene expressionGO:00104672520.122
embryonic organ developmentGO:00485683810.121
cellular nitrogen compound metabolic processGO:00346412900.121
heterocycle biosynthetic processGO:00181302150.118
sprouting angiogenesisGO:0002040530.118
larval developmentGO:000216420.117
digestive tract morphogenesisGO:00485462310.117
reflexGO:006000420.114
localization of cellGO:00516742440.112
positive regulation of biological processGO:00485182530.112
nitrogen compound metabolic processGO:00068073190.110
neuron projection morphogenesisGO:00488121610.110
response to external stimulusGO:00096052640.110
embryonic heart tube morphogenesisGO:00031431080.109
regulation of cellular biosynthetic processGO:00313262450.108
regulation of biosynthetic processGO:00098892500.108
phagocytosisGO:000690930.107
positive regulation of cellular processGO:00485222010.106
nucleic acid templated transcriptionGO:00976591810.104
cell morphogenesis involved in neuron differentiationGO:00486671630.104
guanosine containing compound metabolic processGO:190106840.103
organelle organizationGO:00069962270.102
heart morphogenesisGO:00030071560.102
regulation of cellular macromolecule biosynthetic processGO:20001122220.099
determination of left right symmetryGO:00073681790.098
axon developmentGO:00615641660.097
cognitionGO:005089010.097
regulation of nucleic acid templated transcriptionGO:19035062130.096
protein metabolic processGO:00195381830.095
macromolecule biosynthetic processGO:00090592270.095
regulation of cell shapeGO:000836010.093
regulation of signal transductionGO:00099662250.092
neuron projection developmentGO:00311751800.092
cell motilityGO:00488702440.090
axonogenesisGO:00074091520.090
brain developmentGO:00074202930.089
single organism organelle organizationGO:19025891990.087
rna biosynthetic processGO:00327741810.084
organic substance biosynthetic processGO:19015762890.083
heart loopingGO:0001947940.082
regulation of signalingGO:00230512350.080
exocytosisGO:000688710.080
establishment of cell polarityGO:0030010180.080
neuron developmentGO:00486662620.078
phosphorus metabolic processGO:00067931090.077
protein modification processGO:00362111000.075
organelle localizationGO:0051640490.072
regulation of protein transportGO:005122330.072
detection of mechanical stimulus involved in sensory perception of touchGO:005097620.072
gtp metabolic processGO:004603940.072
cytoskeleton organizationGO:0007010960.071
bmp signaling pathwayGO:0030509520.071
regulation of response to stimulusGO:00485832690.070
biosynthetic processGO:00090582940.069
protein secretionGO:000930610.067
negative regulation of cellular processGO:00485232830.065
chemotaxisGO:00069351040.065
cilium assemblyGO:0042384580.065
actin polymerization or depolymerizationGO:000815420.064
taxisGO:00423301090.064
sensory organ developmentGO:00074233930.064
regulation of nervous system developmentGO:0051960900.062
synaptic growth at neuromuscular junctionGO:005112420.062
regulation of transmembrane receptor protein serine threonine kinase signaling pathwayGO:0090092500.062
detection of external stimulusGO:0009581240.062
head developmentGO:00603223030.061
regulation of protein localization to nucleusGO:190018020.061
regulation of developmental processGO:00507932470.060
stem cell developmentGO:0048864820.060
establishment of localizationGO:00512342440.060
negative regulation of gene expressionGO:0010629650.060
blood vessel developmentGO:00015682460.060
regulation of canonical wnt signaling pathwayGO:0060828340.059
regulation of synapse assemblyGO:005196330.059
establishment of protein localization to organelleGO:007259440.058
nucleobase containing compound biosynthetic processGO:00346542050.058
regulation of cell communicationGO:00106462320.057
transmembrane receptor protein serine threonine kinase signaling pathwayGO:0007178680.057
regulation of transcription from rna polymerase ii promoterGO:00063571140.057
positive regulation of epithelial cell proliferationGO:005067910.056
regionalizationGO:00030022740.056
microtubule cytoskeleton organizationGO:0000226330.056
somite developmentGO:0061053960.056
organic cyclic compound biosynthetic processGO:19013622230.055
negative regulation of cell communicationGO:0010648960.055
response to organic substanceGO:00100331530.055
protein targeting to nucleusGO:004474430.055
guanosine containing compound catabolic processGO:190106920.054
regulation of multicellular organismal developmentGO:20000262230.054
stem cell maintenanceGO:001982740.054
regulation of neural precursor cell proliferationGO:200017730.053
muscle structure developmentGO:00610611960.053
positive regulation of cell cycleGO:004578730.053
transcription from rna polymerase ii promoterGO:0006366800.052
protein import into nucleusGO:000660630.052
determination of bilateral symmetryGO:00098552040.052
neurological system processGO:0050877620.051
regulation of establishment of protein localizationGO:007020140.050
regulation of biological qualityGO:00650082630.049
sensory perception of touchGO:005097520.049
positive regulation of transportGO:005105020.048
cilium morphogenesisGO:0060271850.048
canonical wnt signaling pathwayGO:0060070480.048
formation of primary germ layerGO:0001704620.048
chemosensory behaviorGO:000763510.048
retina development in camera type eyeGO:00600411460.048
positive regulation of striated muscle cell differentiationGO:005115510.047
protein localization to nucleusGO:003450430.047
cellular protein modification processGO:00064641000.047
single fertilizationGO:000733830.046
gtp catabolic processGO:000618420.046
nuclear transportGO:005116940.046
startle responseGO:000196440.045
regulation of transcription dna templatedGO:00063552130.045
striated muscle cell differentiationGO:00511461290.045
regulation of phosphorus metabolic processGO:0051174430.045
epidermal cell fate specificationGO:000995740.044
agingGO:000756820.044
ameboidal type cell migrationGO:00016671430.043
spermatid developmentGO:000728620.043
sensory perception of mechanical stimulusGO:0050954160.043
primary neural tube formationGO:001402010.043
meiotic nuclear divisionGO:000712640.043
determination of heart left right asymmetryGO:00613711170.042
macromolecule modificationGO:00434121110.042
fertilizationGO:000956630.041
regulation of cardiac muscle tissue developmentGO:005502410.041
single organism localizationGO:19025782250.041
somatic stem cell maintenanceGO:003501910.041
nucleocytoplasmic transportGO:000691340.041
regulation of cell proliferation involved in heart morphogenesisGO:200013620.041
axon guidanceGO:0007411860.041
regulation of bmp signaling pathwayGO:0030510390.040
regulation of stem cell differentiationGO:200073640.040
cellular protein metabolic processGO:00442671290.040
positive regulation of stress activated protein kinase signaling cascadeGO:007030430.039
negative regulation of response to stimulusGO:00485851040.039
compound eye developmentGO:004874920.039
negative regulation of signalingGO:0023057960.039
muscle cell differentiationGO:00426921390.039
tissue migrationGO:0090130370.039
gland developmentGO:00487321430.039
regulation of dna replicationGO:000627530.038
immune system processGO:00023762410.038
nuclear importGO:005117030.038
microtubule based processGO:0007017600.037
muscle tissue developmentGO:00605371100.037
protein importGO:001703830.037
cellular biosynthetic processGO:00442492860.036
post embryonic organ developmentGO:004856940.036
embryonic organ morphogenesisGO:00485622740.036
cell fate specificationGO:0001708680.036
spindle assembly involved in mitosisGO:009030710.036
phosphate containing compound metabolic processGO:00067961080.036
cellular ketone metabolic processGO:0042180110.035
sensory perceptionGO:0007600390.035
somatic muscle developmentGO:000752540.035
convergent extensionGO:00600261180.034
regulation of protein targetingGO:190353320.034
regulation of intracellular protein transportGO:003315730.034
regulation of neurogenesisGO:0050767870.034
chordate embryonic developmentGO:00430092710.034
regulation of nucleotide catabolic processGO:003081120.034
positive regulation of cellular catabolic processGO:003133130.034
transmembrane receptor protein tyrosine kinase signaling pathwayGO:0007169420.033
regulation of protein import into nucleusGO:004230620.033
cellular response to biotic stimulusGO:007121630.033
regulation of anatomical structure morphogenesisGO:00226031300.033
positive regulation of map kinase activityGO:004340630.032
oxoacid metabolic processGO:0043436310.032
cellular localizationGO:0051641970.032
single organism transportGO:00447652060.032
regulation of cell differentiationGO:00455951420.032
transportGO:00068102200.032
regulation of gtp catabolic processGO:003312420.032
hair cell differentiationGO:0035315320.031
ubiquitin dependent protein catabolic processGO:000651130.031
inner ear developmentGO:00488391260.031
response to abiotic stimulusGO:00096281220.031
stem cell divisionGO:001714510.031
angiogenesisGO:00015251580.031
epidermis developmentGO:0008544480.031
macromolecule localizationGO:0033036540.031
regulation of nucleocytoplasmic transportGO:004682220.030
regulation of phosphate metabolic processGO:0019220430.030
positive regulation of striated muscle tissue developmentGO:004584410.030
regulation of wound healingGO:006104120.030
organonitrogen compound metabolic processGO:1901564740.029
somitogenesisGO:0001756870.029
mesoderm morphogenesisGO:0048332510.029
positive regulation of dna metabolic processGO:005105410.029
sensory perception of chemical stimulusGO:000760630.029
negative regulation of secretionGO:005104820.029
regulation of cysteine type endopeptidase activityGO:2000116210.028
erk1 and erk2 cascadeGO:007037140.028
neural crest formationGO:0014029140.028
response to external biotic stimulusGO:0043207970.028
negative regulation of wnt signaling pathwayGO:0030178300.028
membrane invaginationGO:001032410.028
neural tube developmentGO:0021915620.028
p38mapk cascadeGO:003806610.028
response to carbohydrateGO:000974330.028
regulation of cellular component movementGO:0051270550.028
regulation of synaptic growth at neuromuscular junctionGO:000858210.028
ear developmentGO:00435831270.028
positive regulation of nitrogen compound metabolic processGO:0051173690.028
cell migrationGO:00164772370.027
phagocytosis engulfmentGO:000691110.027
mesoderm developmentGO:0007498880.027
hematopoietic or lymphoid organ developmentGO:00485341910.027
negative regulation of signal transductionGO:0009968940.027
regulation of reactive oxygen species metabolic processGO:200037720.027
regulation of myotube differentiationGO:001083020.027
blood vessel morphogenesisGO:00485142160.027
cellular response to organic substanceGO:00713101050.027
response to radiationGO:0009314510.026
positive regulation of muscle cell differentiationGO:005114910.026
protein polymerizationGO:005125840.026
developmental programmed cell deathGO:001062340.026
proteasome mediated ubiquitin dependent protein catabolic processGO:004316120.026
positive regulation of purine nucleotide catabolic processGO:003312310.026
amine metabolic processGO:000930820.026
wnt signaling pathwayGO:0016055800.026
positive regulation of macromolecule metabolic processGO:0010604930.026
multicellular organism growthGO:003526440.026
positive regulation of metabolic processGO:00098931080.026
striated muscle cell developmentGO:00550021080.025
epithelium migrationGO:0090132250.025
mesenchyme developmentGO:00604851270.025
positive regulation of secretionGO:005104710.025
kupffer s vesicle developmentGO:0070121500.025
cell cycle processGO:0022402530.025
regulation of erk1 and erk2 cascadeGO:007037240.025
response to amino acidGO:004320020.025
actin filament polymerizationGO:003004120.025
macromolecular complex disassemblyGO:003298410.024
regulation of programmed cell deathGO:00430671010.024
regulation of rho protein signal transductionGO:003502320.024
cellular component disassemblyGO:002241110.024
cellular component assemblyGO:00226071700.024
ventricular cardiac muscle tissue morphogenesisGO:005501020.024
regulation of cellular amine metabolic processGO:003323800.024
negative regulation of epithelial cell proliferationGO:005068010.024
lateral line system developmentGO:0048925760.024
positive regulation of exocytosisGO:004592110.024
positive regulation of neuron apoptotic processGO:004352510.024
neurotransmitter transportGO:000683620.023
regulation of multicellular organism growthGO:004001440.023
camera type eye developmentGO:00430102220.023
epithelial tube morphogenesisGO:00605621480.023
neutrophil mediated immunityGO:000244610.023
positive regulation of gene expressionGO:0010628710.023
response to glucoseGO:000974930.023
apoptotic processGO:00069151160.023
regulation of cellular amino acid metabolic processGO:000652100.023
leukocyte homeostasisGO:000177620.023
establishment of mitotic spindle orientationGO:0000132100.023
small molecule metabolic processGO:0044281770.023
positive regulation of cellular component biogenesisGO:004408930.023
regulation of purine nucleotide catabolic processGO:003312120.023
exocrine system developmentGO:0035272280.023
pronephros developmentGO:0048793690.023
vasculature developmentGO:00019442780.022
mesenchymal cell developmentGO:0014031780.022
regulation of neutrophil migrationGO:190262260.022
system processGO:00030081850.022
negative regulation of protein localization to nucleusGO:190018120.022
spindle assemblyGO:005122520.022
centrosome cycleGO:000709810.022
dorsal ventral pattern formationGO:00099531250.022
regulation of cellular ketone metabolic processGO:001056570.022
convergent extension involved in gastrulationGO:0060027710.022
establishment of localization in cellGO:0051649770.022
cell proliferation involved in heart morphogenesisGO:006132320.022
cytokinesisGO:000091030.021
regulation of exocytosisGO:001715710.021
regulation of wnt signaling pathwayGO:0030111530.021
production of molecular mediator of immune responseGO:000244020.021
actin cytoskeleton organizationGO:0030036630.021
metal ion homeostasisGO:0055065260.021
modification dependent protein catabolic processGO:001994130.021
cellular response to external stimulusGO:007149620.021
negative regulation of bmp signaling pathwayGO:0030514130.021
mesoderm formationGO:0001707430.021
regulation of protein complex assemblyGO:004325430.021
meiotic chromosome segregationGO:004513230.021
regulation of cytokine productionGO:000181730.021
regulation of fibroblast growth factor receptor signaling pathwayGO:0040036200.021
single organism nuclear importGO:190259330.020
cell projection assemblyGO:0030031640.020
spermatid differentiationGO:004851520.020
cellular amine metabolic processGO:004410620.020
cardiac muscle tissue developmentGO:0048738480.020
keratinocyte differentiationGO:003021600.020
response to monosaccharideGO:003428430.020
endoderm developmentGO:0007492490.020
membrane fusionGO:006102520.020
regulation of dendrite developmentGO:005077330.020
organic acid metabolic processGO:0006082310.020
positive regulation of mesenchymal cell proliferationGO:000205310.020
epithelial cell morphogenesisGO:000338220.019
transcription dna templatedGO:00063511810.019
organelle assemblyGO:00709251100.019
single organism metabolic processGO:00447102170.019
peptidyl tyrosine dephosphorylationGO:003533510.019
positive regulation of nucleotide catabolic processGO:003081310.019
fatty acid oxidationGO:001939510.019
nuclear migrationGO:000709730.019
regulation of cardiac muscle cell differentiationGO:200072510.019
ventricular cardiac muscle tissue developmentGO:000322930.019
regulation of dendrite morphogenesisGO:004881430.019
lymph vessel developmentGO:0001945270.019
negative regulation of protein transportGO:005122430.019
proteolysis involved in cellular protein catabolic processGO:005160330.019
cellular response to radiationGO:007147840.019
regulation of protein depolymerizationGO:190187910.019
proteasomal protein catabolic processGO:001049820.019
neuron neuron synaptic transmissionGO:000727010.019
ion homeostasisGO:0050801410.019
regulation of cell activationGO:005086510.018
neuron deathGO:0070997210.018
regulation of cell deathGO:00109411030.018
regulation of cytoplasmic transportGO:190364940.018
positive regulation of notch signaling pathwayGO:004574730.018
carbohydrate derivative metabolic processGO:1901135610.018
regulation of cell migrationGO:0030334400.018
multicellular organismal metabolic processGO:004423620.018
positive regulation of transcription dna templatedGO:0045893570.018
hormone transportGO:000991420.018
mitotic cell cycleGO:0000278640.018
centrosome organizationGO:005129710.018
specification of organ identityGO:001009220.018
toll like receptor signaling pathwayGO:000222440.018
macromolecular complex subunit organizationGO:0043933740.018
regulation of response to biotic stimulusGO:000283120.018
regulation of stem cell proliferationGO:007209120.018
regulation of metal ion transportGO:001095940.018
negative regulation of map kinase activityGO:004340720.018
positive regulation of cellular amine metabolic processGO:003324000.018
divalent inorganic cation homeostasisGO:0072507220.018
skeletal system developmentGO:00015011810.018
phospholipase c activating g protein coupled receptor signaling pathwayGO:000720020.017
detection of abiotic stimulusGO:0009582240.017
regulation of vesicle mediated transportGO:006062790.017
adherens junction organizationGO:003433240.017
regulation of gtpase activityGO:004308720.017
cell substrate adhesionGO:003158940.017
regulation of cellular response to growth factor stimulusGO:0090287350.017
regulation of nucleoside metabolic processGO:000911820.017
regulation of autophagyGO:001050630.017
deathGO:00162651210.017
endocardium morphogenesisGO:000316040.017
female meiotic divisionGO:000714320.017
positive regulation of ras gtpase activityGO:003232010.017
detection of stimulus involved in sensory perceptionGO:0050906210.017
lateral inhibitionGO:004633110.017
regulation of cell projection assemblyGO:006049140.017
carboxylic acid metabolic processGO:0019752220.017
regulation of bindingGO:005109830.017
positive regulation of stem cell proliferationGO:200064810.017
establishment of mitotic spindle localizationGO:0040001120.017
germ line stem cell maintenanceGO:003071820.017
positive regulation of nucleoside metabolic processGO:004597910.017
symbiosis encompassing mutualism through parasitismGO:004440340.017
tube closureGO:006060610.017
negative regulation of macromolecule metabolic processGO:0010605760.017
regulation of endocrine processGO:004406020.017
mechanoreceptor differentiationGO:0042490370.017
eye morphogenesisGO:00485921440.017
regulation of catalytic activityGO:0050790550.017
segment polarity determinationGO:000736710.016
response to hexoseGO:000974630.016
myoblast fusionGO:0007520100.016
regulation of dna templated transcription in response to stressGO:004362000.016
positive regulation of cytosolic calcium ion concentrationGO:000720440.016
positive regulation of muscle tissue developmentGO:190186310.016
positive regulation of nucleobase containing compound metabolic processGO:0045935690.016
phosphorylationGO:0016310690.016
muscle cell developmentGO:00550011150.016
spinal cord developmentGO:0021510460.016
heart processGO:0003015710.016
positive regulation of cellular amino acid metabolic processGO:004576400.016
regulation of reproductive processGO:200024140.016
regulation of protein catabolic processGO:004217610.016
cellular component biogenesisGO:00440851780.016
positive regulation of muscle organ developmentGO:004863610.016
regulation of apoptotic processGO:0042981980.016
microtubule organizing center organizationGO:003102310.016
single organism cellular localizationGO:1902580460.016
regulation of locomotionGO:0040012550.016
establishment or maintenance of cell polarityGO:0007163290.016
regulation of cell morphogenesis involved in differentiationGO:0010769380.016
regulation of cell sizeGO:0008361290.016
neurotransmitter secretionGO:000726920.016
single organism membrane fusionGO:004480120.016
positive regulation of cytoskeleton organizationGO:005149530.016
detection of mechanical stimulusGO:0050982110.016
epithelial cell developmentGO:0002064420.015
negative regulation of canonical wnt signaling pathwayGO:0090090210.015
notochord developmentGO:0030903540.015
regulation of blood coagulationGO:003019310.015
cellular amide metabolic processGO:004360340.015
neuron projection guidanceGO:0097485860.015
multi organism processGO:00517041340.015
epithelial cell migrationGO:0010631250.015
regulation of heart growthGO:006042020.015
positive regulation of secretion by cellGO:190353210.015
collagen metabolic processGO:003296320.015
cation homeostasisGO:0055080330.015
aorta developmentGO:003590440.015
regulation of neuron differentiationGO:0045664560.015
regulation of mesenchymal cell proliferationGO:001046410.015
protein complex localizationGO:003150310.015
regulation of neurological system processGO:003164420.015
antimicrobial humoral responseGO:001973020.015
regulation of protein bindingGO:004339330.015
spindle assembly involved in meiosisGO:009030610.015
regulation of skeletal muscle fiber developmentGO:004874220.015
positive regulation of response to stimulusGO:0048584800.015
trabecula morphogenesisGO:006138320.015
immune responseGO:0006955280.015
spindle localizationGO:0051653120.015
response to growth factorGO:0070848390.015
negative regulation of mapk cascadeGO:004340940.015
transmembrane transportGO:00550851200.015
response to endogenous stimulusGO:0009719830.015
inner ear morphogenesisGO:0042472630.015
peptide transportGO:001583310.015
pronuclear migrationGO:003504610.014
regulation of protein polymerizationGO:003227120.014
cardiac cell fate commitmentGO:006091110.014
i kappab kinase nf kappab signalingGO:000724940.014
positive regulation of cellular metabolic processGO:0031325940.014
regulation of transcription from rna polymerase ii promoter in response to stressGO:004361800.014
axonal defasciculationGO:000741420.014
organic substance transportGO:0071702580.014
response to fibroblast growth factorGO:0071774220.014
regulation of cellular protein catabolic processGO:190336210.014
ventral spinal cord developmentGO:0021517350.014
epidermal cell differentiationGO:0009913360.014
regulation of hormone secretionGO:004688320.014
b cell differentiationGO:003018310.014
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathwayGO:0090101220.014
protein phosphorylationGO:0006468470.014

appl2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.037
cancerDOID:16200.014
disease of cellular proliferationDOID:1456600.014
organ system cancerDOID:005068600.014