Danio rerio

17 known processes

eif2ak2

eukaryotic translation initiation factor 2-alpha kinase 2

(Aliases: pkr)

eif2ak2 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
gene expressionGO:00104672520.070
Human Mouse
agingGO:000756820.065
zymogen activationGO:003163830.062
positive regulation of stress activated mapk cascadeGO:003287430.061
Mouse
female sex differentiationGO:004666040.058
establishment of protein localization to organelleGO:007259440.054
larval developmentGO:000216420.053
immune system processGO:00023762410.053
Mouse
regulation of stem cell proliferationGO:007209120.050
Mouse
regulation of reproductive processGO:200024140.050
meiotic nuclear divisionGO:000712640.050
immunoglobulin mediated immune responseGO:001606430.049
plasminogen activationGO:003163930.045
positive regulation of transportGO:005105020.044
nitrogen compound metabolic processGO:00068073190.044
Human
female gonad developmentGO:000858540.043
muscle cell developmentGO:00550011150.043
symbiosis encompassing mutualism through parasitismGO:004440340.042
Human Mouse
signal transductionGO:00071654550.042
Human Mouse
interspecies interaction between organismsGO:004441940.041
Human Mouse
nucleobase containing compound metabolic processGO:00061392740.041
Human
negative regulation of biological processGO:00485193040.041
Human Mouse
cellular nitrogen compound metabolic processGO:00346412900.039
Human
embryonic organ developmentGO:00485683810.039
cellular macromolecule metabolic processGO:00442603910.039
regulation of cellular metabolic processGO:00313233200.039
Human Mouse
nik nf kappab signalingGO:003806110.039
Mouse
positive regulation of stress activated protein kinase signaling cascadeGO:007030430.039
Mouse
stem cell proliferationGO:007208940.039
Mouse
regulation of cytokine productionGO:000181730.038
Mouse
positive regulation of cytokine productionGO:000181920.037
Mouse
regulation of signalingGO:00230512350.037
Human Mouse
protein importGO:001703830.036
protein localization to nucleusGO:003450430.036
regulation of cell communicationGO:00106462320.036
Human Mouse
determination of left right symmetryGO:00073681790.035
sensory organ developmentGO:00074233930.035
regulation of stem cell differentiationGO:200073640.035
Mouse
regulation of establishment of protein localizationGO:007020140.035
determination of bilateral symmetryGO:00098552040.034
negative regulation of cellular processGO:00485232830.034
Human Mouse
regulation of protein transportGO:005122330.034
cellular biosynthetic processGO:00442492860.034
Human Mouse
regulation of hormone secretionGO:004688320.034
protein metabolic processGO:00195381830.034
single organism nuclear importGO:190259330.033
cell substrate adhesionGO:003158940.033
regulation of innate immune responseGO:0045088110.033
regulation of meiotic cell cycleGO:005144510.033
regulation of cell substrate adhesionGO:001081010.033
positive regulation of lymphocyte mediated immunityGO:000270810.033
i kappab kinase nf kappab signalingGO:000724940.033
positive regulation of cell cycleGO:004578730.032
protein import into nucleusGO:000660630.031
androgen metabolic processGO:000820920.031
regulation of cellular biosynthetic processGO:00313262450.031
Human
response to topologically incorrect proteinGO:003596620.031
Mouse
cell surface receptor signaling pathwayGO:00071663250.031
organic substance biosynthetic processGO:19015762890.031
Human Mouse
cellular response to topologically incorrect proteinGO:003596720.030
Mouse
nuclear transportGO:005116940.030
development of primary female sexual characteristicsGO:004654540.030
regulation of biological qualityGO:00650082630.030
organic cyclic compound metabolic processGO:19013603010.029
Human
response to drugGO:004249330.029
response to other organismGO:0051707970.029
Human
organism emergence from protective structureGO:007168440.029
response to external stimulusGO:00096052640.028
Human
regulation of cytoplasmic transportGO:190364940.028
pericardium developmentGO:006003910.028
cellular response to unfolded proteinGO:003462020.028
Mouse
interaction with hostGO:005170140.028
nuclear importGO:005117030.028
regulation of primary metabolic processGO:00800903110.028
Human
regulation of signal transductionGO:00099662250.028
Human Mouse
regulation of macromolecule metabolic processGO:00602553170.028
Human
chordate embryonic developmentGO:00430092710.027
meiotic cell cycle processGO:190304630.027
positive regulation of leukocyte mediated immunityGO:000270510.027
multi organism cellular processGO:004476420.027
Human Mouse
positive regulation of leukocyte mediated cytotoxicityGO:000191210.027
nucleocytoplasmic transportGO:000691340.027
immune system developmentGO:00025201910.027
Mouse
cellular aromatic compound metabolic processGO:00067252950.027
Human
nitric oxide biosynthetic processGO:000680920.027
muscle structure developmentGO:00610611960.027
multicellular organismal response to stressGO:003355520.027
regulation of natural killer cell mediated cytotoxicityGO:004226910.026
regulation of i kappab kinase nf kappab signalingGO:004312240.026
positive regulation of secretion by cellGO:190353210.026
positive regulation of catabolic processGO:000989640.025
embryonic organ morphogenesisGO:00485622740.025
regulation of protein targetingGO:190353320.025
defense responseGO:0006952470.025
hematopoietic stem cell differentiationGO:0060218200.025
Mouse
protein targeting to nucleusGO:004474430.025
positive regulation of cellular component biogenesisGO:004408930.025
peptide metabolic processGO:000651810.025
nucleobase containing compound biosynthetic processGO:00346542050.025
Human
organonitrogen compound metabolic processGO:1901564740.025
regulation of macromolecule biosynthetic processGO:00105562250.025
Human
nucleic acid metabolic processGO:00903042440.025
Human
cellular response to external stimulusGO:007149620.025
regulation of protein import into nucleusGO:004230620.024
regulation of metabolic processGO:00192223590.024
Human Mouse
negative regulation of cellular catabolic processGO:003133030.024
pericardium morphogenesisGO:000334410.024
establishment of localizationGO:00512342440.024
protein maturationGO:0051604120.024
positive regulation of cell divisionGO:005178120.024
regulation of natural killer cell mediated immunityGO:000271510.023
positive regulation of biological processGO:00485182530.023
Human Mouse
protein secretionGO:000930610.023
hormone secretionGO:004687920.023
regulation of bindingGO:005109830.023
membrane lipid biosynthetic processGO:004646720.023
production of molecular mediator of immune responseGO:000244020.023
specification of symmetryGO:00097992040.023
inner ear developmentGO:00488391260.023
regulation of nucleocytoplasmic transportGO:004682220.023
positive regulation of cellular catabolic processGO:003133130.023
innate immune responseGO:0045087130.023
regulation of protein localization to nucleusGO:190018020.023
regulation of production of molecular mediator of immune responseGO:000270010.022
embryonic skeletal system developmentGO:0048706970.022
somatic muscle developmentGO:000752540.022
b cell activationGO:004211320.022
regulation of multicellular organismal developmentGO:20000262230.022
Mouse
organic cyclic compound biosynthetic processGO:19013622230.022
Human
regulation of intracellular protein transportGO:003315730.022
hormone transportGO:000991420.022
regulation of nitrogen compound metabolic processGO:00511712510.022
Human
regulation of response to stimulusGO:00485832690.022
Human Mouse
autophagyGO:000691440.021
stem cell maintenanceGO:001982740.021
cellular protein catabolic processGO:004425740.021
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domainsGO:000246040.021
positive regulation of cytoskeleton organizationGO:005149530.021
cell motilityGO:00488702440.021
response to external biotic stimulusGO:0043207970.021
Human
rna biosynthetic processGO:00327741810.021
Human
response to biotic stimulusGO:0009607970.021
Human
response to carbohydrateGO:000974330.020
synaptic target recognitionGO:000803910.020
positive regulation of secretionGO:005104710.020
cellular response to starvationGO:000926710.020
positive regulation of gtp catabolic processGO:003312610.020
cell proliferationGO:0008283800.020
Human Mouse
gtp metabolic processGO:004603940.020
regulation of multicellular organismal processGO:00512392770.020
Mouse
biosynthetic processGO:00090582940.020
Human Mouse
regulation of cell shapeGO:000836010.020
rna localizationGO:000640340.020
sphingolipid biosynthetic processGO:003014820.020
er nucleus signaling pathwayGO:000698420.020
Mouse
heterocycle metabolic processGO:00464832900.020
Human
positive regulation of cell adhesionGO:004578510.020
striated muscle cell differentiationGO:00511461290.020
reactive nitrogen species metabolic processGO:200105700.020
response to alkaloidGO:004327920.020
phagocytosisGO:000690930.020
positive regulation of cell activationGO:005086710.020
cellular response to nutrient levelsGO:003166920.020
striated muscle cell developmentGO:00550021080.019
striated muscle tissue developmentGO:00147061100.019
hormone biosynthetic processGO:004244630.019
maintenance of locationGO:005123540.019
endoplasmic reticulum unfolded protein responseGO:003096820.019
Mouse
carbon dioxide transportGO:001567030.019
single organism metabolic processGO:00447102170.019
Human Mouse
cellular carbohydrate metabolic processGO:004426240.019
positive regulation of cell substrate adhesionGO:001081110.019
regulation of muscle contractionGO:000693730.019
positive regulation of transcription elongation from rna polymerase ii promoterGO:003296810.019
response to chemicalGO:00422213200.019
Human Mouse
skeletal system developmentGO:00015011810.018
gtp catabolic processGO:000618420.018
positive regulation of i kappab kinase nf kappab signalingGO:004312330.018
negative regulation of reproductive processGO:200024230.018
carbohydrate homeostasisGO:003350010.018
regulation of skeletal muscle tissue developmentGO:004864140.018
regulation of protein catabolic processGO:004217610.018
complement activationGO:000695630.018
lipid storageGO:001991510.018
regulation of dna recombinationGO:000001820.018
viral processGO:001603210.018
Human Mouse
meiosis iGO:000712710.018
cellular amide metabolic processGO:004360340.018
cellular macromolecule biosynthetic processGO:00346452240.018
Human Mouse
cellular amine metabolic processGO:004410620.018
stem cell divisionGO:001714510.017
gastrulationGO:00073692080.017
negative regulation of cytokine productionGO:000181810.017
response to unfolded proteinGO:000698620.017
Mouse
homeostatic processGO:00425921420.017
amine metabolic processGO:000930820.017
aromatic compound biosynthetic processGO:00194382170.017
Human
circadian sleep wake cycleGO:004274520.017
regulation of endocrine processGO:004406020.017
negative regulation of protein phosphorylationGO:000193340.017
positive regulation of cellular amine metabolic processGO:003324000.017
translational initiationGO:000641330.017
regulation of cellular amino acid metabolic processGO:000652100.017
peptidyl serine modificationGO:001820920.017
membrane invaginationGO:001032410.016
fatty acid transportGO:001590810.016
cellular component movementGO:00069283350.016
cell killingGO:000190620.016
response to corticosteroidGO:003196010.016
single organism localizationGO:19025782250.016
positive regulation of myeloid cell differentiationGO:004563920.016
guanosine containing compound catabolic processGO:190106920.016
brain developmentGO:00074202930.016
regulation of transporter activityGO:003240920.016
transportGO:00068102200.016
long chain fatty acid transportGO:001590910.016
energy reserve metabolic processGO:000611220.016
leukocyte proliferationGO:007066110.016
regulation of symbiosis encompassing mutualism through parasitismGO:004390310.016
Human Mouse
organelle organizationGO:00069962270.016
regulation of metal ion transportGO:001095940.016
nitric oxide metabolic processGO:004620920.016
long chain fatty acid metabolic processGO:000167610.016
cellular protein metabolic processGO:00442671290.016
somitogenesisGO:0001756870.016
centrosome organizationGO:005129710.016
regulation of nucleobase containing compound metabolic processGO:00192192500.016
Human
lateral line system developmentGO:0048925760.016
regulation of gene expressionGO:00104682650.016
Human
regulation of rna biosynthetic processGO:20011412130.016
Human
cellular response to extracellular stimulusGO:003166820.016
regulation of cellular amine metabolic processGO:003323800.016
regulation of hematopoietic progenitor cell differentiationGO:190153210.015
Mouse
b cell mediated immunityGO:001972430.015
response to stressGO:00069502630.015
Mouse
calcium ion importGO:007050940.015
skeletal system morphogenesisGO:00487051020.015
cellular nitrogen compound biosynthetic processGO:00442712180.015
Human
positive regulation of dna metabolic processGO:005105410.015
negative regulation of catabolic processGO:000989530.015
regulation of cell activationGO:005086510.015
hatchingGO:003518840.015
vasculature developmentGO:00019442780.015
post embryonic organ developmentGO:004856940.015
golgi vesicle transportGO:004819330.015
negative regulation of translationGO:001714810.015
Human
mechanosensory lateral line system developmentGO:0048881490.015
protein acetylationGO:000647320.015
peptidyl lysine acetylationGO:001839420.015
gas transportGO:001566930.015
guanosine containing compound metabolic processGO:190106840.015
fin developmentGO:0033333770.015
anion transportGO:0006820380.015
regulation of cardiac muscle contractionGO:005511720.015
nucleic acid templated transcriptionGO:00976591810.015
Human
response to glucoseGO:000974930.015
mononuclear cell proliferationGO:003294310.015
regulation of protein complex assemblyGO:004325430.015
Mouse
regulation of cellular protein catabolic processGO:190336210.015
cellular response to lipopolysaccharideGO:007122230.015
regulation of nucleotide catabolic processGO:003081120.015
embryo development ending in birth or egg hatchingGO:00097922710.015
positive regulation of reproductive processGO:200024320.015
leukocyte mediated cytotoxicityGO:000190910.015
positive regulation of immune effector processGO:000269930.015
ovulation cycle processGO:002260220.015
adherens junction organizationGO:003433240.015
cell proliferation involved in heart morphogenesisGO:006132320.015
phagocytosis engulfmentGO:000691110.015
cellular response to biotic stimulusGO:007121630.015
hemopoiesisGO:00300971830.015
Mouse
macroautophagyGO:001623610.014
one carbon compound transportGO:0019755140.014
nucleic acid transportGO:005065720.014
morphogenesis of an epithelial foldGO:006057110.014
regulation of purine nucleotide catabolic processGO:003312120.014
circadian sleep wake cycle sleepGO:005080210.014
smooth muscle contractionGO:000693920.014
negative regulation of intracellular transportGO:003238730.014
photoreceptor cell fate specificationGO:004370410.014
rna metabolic processGO:00160702190.014
Human
regulation of epithelial cell proliferationGO:005067830.014
protein complex localizationGO:003150310.014
regulation of nucleoside metabolic processGO:000911820.014
modification of morphology or physiology of other organism involved in symbiotic interactionGO:005181740.014
lymphocyte proliferationGO:004665110.014
muscle tissue developmentGO:00605371100.014
positive regulation of nucleoside metabolic processGO:004597910.014
regulation of skeletal muscle fiber developmentGO:004874220.014
protein processingGO:0016485120.014
regulation of tube sizeGO:003515020.014
modification dependent protein catabolic processGO:001994130.014
regulation of ion transmembrane transporter activityGO:003241220.014
ubiquitin dependent protein catabolic processGO:000651130.014
macromolecular complex disassemblyGO:003298410.014
single organism organelle organizationGO:19025891990.014
positive regulation of cell killingGO:003134320.014
proteolysis involved in cellular protein catabolic processGO:005160330.014
dorsal ventral pattern formationGO:00099531250.014
somite developmentGO:0061053960.014
transcription dna templatedGO:00063511810.014
Human
endocrine processGO:005088620.014
astrocyte differentiationGO:004870810.014
rna transportGO:005065820.014
regulation of wound healingGO:006104120.013
internal protein amino acid acetylationGO:000647520.013
natural killer cell mediated immunityGO:000222810.013
regulation of response to nutrient levelsGO:003210710.013
circadian sleep wake cycle processGO:002241020.013
oxidation reduction processGO:0055114410.013
negative regulation of protein localization to nucleusGO:190018120.013
regulation of gtp catabolic processGO:003312420.013
macromolecule biosynthetic processGO:00090592270.013
Human Mouse
protein localization to plasma membraneGO:007265910.013
multi organism processGO:00517041340.013
Human Mouse
cell matrix adhesionGO:000716040.013
negative regulation of cytoplasmic transportGO:190365020.013
retinal rod cell developmentGO:004654840.013
carboxylic acid metabolic processGO:0019752220.013
negative regulation of nucleocytoplasmic transportGO:004682320.013
positive regulation of map kinase activityGO:004340630.013
Human
regulation of organelle assemblyGO:190211540.013
regulation of striated muscle contractionGO:000694220.013
purine ribonucleoside monophosphate catabolic processGO:000916940.013
regulation of transcription dna templatedGO:00063552130.013
Human
cellular component disassemblyGO:002241110.013
appendage morphogenesisGO:0035107560.013
estrogen metabolic processGO:000821020.013
response to monosaccharideGO:003428430.013
regulation of cellular ketone metabolic processGO:001056570.013
muscle fiber developmentGO:0048747520.013
regulation of leukocyte mediated immunityGO:000270310.013
muscle cell differentiationGO:00426921390.013
negative regulation of epithelial cell proliferationGO:005068010.013
regulation of blood vessel sizeGO:005088020.013
regulation of protein ubiquitinationGO:003139630.013
membrane fusionGO:006102520.013
immunoglobulin productionGO:000237710.013
stem cell differentiationGO:00488631170.013
Mouse
heart processGO:0003015710.013
regulation of response to extracellular stimulusGO:003210410.013
localization of cellGO:00516742440.013
protein complex disassemblyGO:004324110.013
microtubule organizing center organizationGO:003102310.013
compound eye developmentGO:004874920.012
actin mediated cell contractionGO:007025210.012
cellular protein modification processGO:00064641000.012
establishment of localization in cellGO:0051649770.012
proteasomal protein catabolic processGO:001049820.012
regulation of response to cytokine stimulusGO:006075930.012
positive regulation of nucleotide catabolic processGO:003081310.012
establishment of endothelial barrierGO:006102830.012
regulation of protein modification by small protein conjugation or removalGO:190332030.012
negative regulation of mapk cascadeGO:004340940.012
embryonic cranial skeleton morphogenesisGO:0048701900.012
regulation of autophagyGO:001050630.012
regulation of mesenchymal cell proliferationGO:001046410.012
multicellular organism growthGO:003526440.012
blood vessel developmentGO:00015682460.012
positive regulation of nitrogen compound metabolic processGO:0051173690.012
regulation of lymphocyte mediated immunityGO:000270610.012
heterocycle biosynthetic processGO:00181302150.012
Human
protein homooligomerizationGO:005126030.012
embryonic skeletal system morphogenesisGO:0048704930.012
multicellular organismal metabolic processGO:004423620.012
tissue remodelingGO:004877140.012
regulation of proteolysis involved in cellular protein catabolic processGO:190305010.012
reactive oxygen species biosynthetic processGO:190340910.012
regulation of circadian sleep wake cycle sleepGO:004518710.012
collagen metabolic processGO:003296320.012
modification dependent macromolecule catabolic processGO:004363230.012
cell cycle g1 s phase transitionGO:004484310.012
cellular component morphogenesisGO:00329893360.012
neuromast developmentGO:0048884460.012
regionalizationGO:00030022740.012
organelle fusionGO:004828430.012
negative regulation of macromolecule metabolic processGO:0010605760.012
Human
appendage developmentGO:0048736800.012
cartilage developmentGO:0051216960.012
response to glucocorticoidGO:005138410.012
protein modification processGO:00362111000.012
negative regulation of multi organism processGO:004390130.012
Human Mouse
atp catabolic processGO:000620040.012
cellular response to organic substanceGO:00713101050.012
Mouse
cell morphogenesisGO:00009022890.011
androgen biosynthetic processGO:000670210.011
sleepGO:003043110.011
regulation of developmental processGO:00507932470.011
Mouse
renal tubule morphogenesisGO:006133310.011
regulation of inflammatory responseGO:005072720.011
cellular response to molecule of bacterial originGO:007121930.011
positive regulation of cytosolic calcium ion concentrationGO:000720440.011
regulation of rna metabolic processGO:00512522240.011
Human
regulation of circadian rhythmGO:004275240.011
angiogenesisGO:00015251580.011
ear developmentGO:00435831270.011
cell agingGO:000756920.011
positive regulation of cellular metabolic processGO:0031325940.011
Human Mouse
protein polyubiquitinationGO:000020940.011
positive regulation of cellular amino acid metabolic processGO:004576400.011
muscle organ developmentGO:00075171010.011
phosphate containing compound metabolic processGO:00067961080.011
regulation of gtpase activityGO:004308720.011
regulation of sodium ion transportGO:000202820.011
cellular component assemblyGO:00226071700.011
Mouse
immune effector processGO:0002252230.011
positive regulation of jnk cascadeGO:004633030.011
ribonucleoside monophosphate catabolic processGO:000915840.011
cellular response to radiationGO:007147840.011
regulation of leukocyte mediated cytotoxicityGO:000191010.011
regulation of translational initiationGO:000644610.011
response to bacteriumGO:0009617580.011
photoreceptor cell fate commitmentGO:004655210.011
eye developmentGO:00016542770.011
connective tissue developmentGO:0061448990.011
response to nutrientGO:000758430.011
morphogenesis of an epitheliumGO:00020093330.011
regulation of myotube differentiationGO:001083020.011
positive regulation of nucleobase containing compound metabolic processGO:0045935690.011
centrosome cycleGO:000709810.011
nucleoside monophosphate catabolic processGO:000912540.011
cell migrationGO:00164772370.011
calcium mediated signalingGO:001972220.011
modification of morphology or physiology of other organismGO:003582140.011
regulation of immune system processGO:0002682340.011
Mouse
cytoskeleton organizationGO:0007010960.011
cognitionGO:005089010.011
negative regulation of kinase activityGO:003367340.011
fluid transportGO:0042044170.011
protein dephosphorylationGO:000647030.011
negative regulation of protein import into nucleusGO:004230820.011
heart contractionGO:0060047710.010
positive regulation of gliogenesisGO:001401520.010
sex determinationGO:000753010.010
negative regulation of intracellular protein transportGO:009031730.010
oxoacid metabolic processGO:0043436310.010
regulation of cellular carbohydrate metabolic processGO:001067540.010
cellular component biogenesisGO:00440851780.010
Mouse
regulation of cyclin dependent protein serine threonine kinase activityGO:000007910.010
positive regulation of gtpase activityGO:004354710.010
peptidyl serine phosphorylationGO:001810510.010
antimicrobial humoral responseGO:001973020.010
regulation of calcium ion transportGO:005192420.010
regulation of blood pressureGO:000821710.010
regulation of neural precursor cell proliferationGO:200017730.010
endosomal transportGO:001619720.010
positive regulation of cellular processGO:00485222010.010
Human Mouse
tube morphogenesisGO:00352393490.010
somatic stem cell maintenanceGO:003501910.010
skeletal muscle organ developmentGO:0060538780.010
epithelial cell differentiationGO:00308551160.010
regulation of apoptotic processGO:0042981980.010
Mouse
proteasome mediated ubiquitin dependent protein catabolic processGO:004316120.010
positive regulation of innate immune responseGO:004508980.010
regulation of cell killingGO:003134120.010
response to ketoneGO:190165410.010
synaptic vesicle transportGO:004848910.010
alcohol biosynthetic processGO:004616520.010
locomotionGO:00400113130.010
neuroblast proliferationGO:000740520.010
smooth muscle tissue developmentGO:004874510.010
phosphorylationGO:0016310690.010
establishment of synaptic vesicle localizationGO:009748010.010
single organism membrane fusionGO:004480120.010
positive regulation of macromolecule metabolic processGO:0010604930.010
Human
long chain fatty acid biosynthetic processGO:004275910.010
response to hexoseGO:000974630.010
regulation of molecular functionGO:0065009700.010
Human
peptide transportGO:001583310.010
positive regulation of neuron deathGO:190121610.010

eif2ak2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.036
nervous system diseaseDOID:86300.018
eye and adnexa diseaseDOID:149200.015
sensory system diseaseDOID:005015500.015
eye diseaseDOID:561400.015
musculoskeletal system diseaseDOID:1700.013
disease of metabolismDOID:001466700.012
disease of cellular proliferationDOID:1456600.011