IMP: Integrative Multi-species Prediction

Danio rerio

0 known processes

smad7

MAD, mothers against decapentaplegic homolog 7 (Drosophila)

(Aliases: wu:fj60c10,madh7)

Entrez: 326282
ZFIN: ZDB-GENE-030128-3
Ensembl: ENSDARG00000016858
UniProtKB: Q6NZT3

Process Predictions
Disease Predictions

smad7 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
aromatic compound biosynthetic process	GO:0019438	217	0.936	Human Zebrafish Fly
ameboidal type cell migration	GO:0001667	143	0.909	Zebrafish
cellular macromolecule biosynthetic process	GO:0034645	224	0.896	Human Zebrafish Fly
regulation of multicellular organismal development	GO:2000026	223	0.841	Zebrafish Fly
cellular aromatic compound metabolic process	GO:0006725	295	0.817	Human Zebrafish Fly
biosynthetic process	GO:0009058	294	0.809	Human Zebrafish Fly
cellular nitrogen compound biosynthetic process	GO:0044271	218	0.801	Human Zebrafish Fly
regulation of transcription dna templated	GO:0006355	213	0.790	Human Zebrafish Mouse Fly
rna biosynthetic process	GO:0032774	181	0.771	Human Zebrafish Fly
sensory organ development	GO:0007423	393	0.760	Zebrafish
nucleic acid templated transcription	GO:0097659	181	0.759	Human Zebrafish Fly
sympathetic nervous system development	GO:0048485	3	0.739
regulation of primary metabolic process	GO:0080090	311	0.718	Human Zebrafish Mouse Fly
cellular biosynthetic process	GO:0044249	286	0.708	Human Zebrafish Fly
heterocycle biosynthetic process	GO:0018130	215	0.706	Human Zebrafish Fly
cellular nitrogen compound metabolic process	GO:0034641	290	0.693	Human Zebrafish Fly
regulation of nucleic acid templated transcription	GO:1903506	213	0.683	Human Zebrafish Mouse Fly
regulation of rna metabolic process	GO:0051252	224	0.682	Human Zebrafish Mouse Fly
camera type eye morphogenesis	GO:0048593	108	0.680
cell motility	GO:0048870	244	0.662	Zebrafish Fly
regulation of macromolecule metabolic process	GO:0060255	317	0.639	Human Zebrafish Mouse Fly
organic cyclic compound metabolic process	GO:1901360	301	0.636	Human Zebrafish Fly
sensory organ morphogenesis	GO:0090596	200	0.600	Zebrafish
eye development	GO:0001654	277	0.596
nucleic acid metabolic process	GO:0090304	244	0.539	Human Zebrafish Fly
cellular macromolecule metabolic process	GO:0044260	391	0.535	Human Zebrafish Mouse Fly
nucleobase containing compound biosynthetic process	GO:0034654	205	0.533	Human Zebrafish Fly
regulation of nitrogen compound metabolic process	GO:0051171	251	0.523	Human Zebrafish Mouse Fly
negative regulation of cellular process	GO:0048523	283	0.507	Human Zebrafish Mouse Fly
regulation of gene expression	GO:0010468	265	0.506	Human Zebrafish Mouse Fly
rna metabolic process	GO:0016070	219	0.503	Human Zebrafish Fly
negative regulation of nucleobase containing compound metabolic process	GO:0045934	59	0.478	Human Zebrafish
nitrogen compound metabolic process	GO:0006807	319	0.475	Human Zebrafish Fly
regulation of nucleobase containing compound metabolic process	GO:0019219	250	0.467	Human Zebrafish Mouse Fly
regulation of rna biosynthetic process	GO:2001141	213	0.459	Human Zebrafish Mouse Fly
regulation of cell differentiation	GO:0045595	142	0.454	Zebrafish Fly
inner ear morphogenesis	GO:0042472	63	0.454	Zebrafish
regulation of cellular biosynthetic process	GO:0031326	245	0.451	Human Zebrafish Mouse Fly
regulation of cell development	GO:0060284	100	0.449	Zebrafish
organic substance biosynthetic process	GO:1901576	289	0.438	Human Zebrafish Fly
transcription dna templated	GO:0006351	181	0.436	Human Zebrafish Fly
ear morphogenesis	GO:0042471	64	0.417	Zebrafish
regulation of cellular macromolecule biosynthetic process	GO:2000112	222	0.405	Human Zebrafish Mouse Fly
head development	GO:0060322	303	0.404
cell morphogenesis involved in differentiation	GO:0000904	195	0.399	Fly
regulation of biosynthetic process	GO:0009889	250	0.397	Human Zebrafish Mouse Fly
regulation of cell morphogenesis	GO:0022604	42	0.394
brain development	GO:0007420	293	0.391
neuron projection development	GO:0031175	180	0.389	Fly
nucleobase containing compound metabolic process	GO:0006139	274	0.386	Human Zebrafish Fly
otic placode formation	GO:0043049	23	0.379	Zebrafish
macromolecule biosynthetic process	GO:0009059	227	0.377	Human Zebrafish Fly
chordate embryonic development	GO:0043009	271	0.376
axonogenesis	GO:0007409	152	0.357	Fly
embryo development ending in birth or egg hatching	GO:0009792	271	0.355
regulation of macromolecule biosynthetic process	GO:0010556	225	0.352	Human Zebrafish Mouse Fly
regulation of multicellular organismal process	GO:0051239	277	0.347	Zebrafish Mouse Fly
regulation of binding	GO:0051098	3	0.347
negative regulation of cell communication	GO:0010648	96	0.339	Human Mouse Fly
neural tube development	GO:0021915	62	0.331
cellular component movement	GO:0006928	335	0.328	Zebrafish Fly
forebrain development	GO:0030900	96	0.326
ectodermal placode morphogenesis	GO:0071697	32	0.325	Zebrafish
cellular protein modification process	GO:0006464	100	0.324	Human Mouse
heterocycle metabolic process	GO:0046483	290	0.323	Human Zebrafish Fly
eye morphogenesis	GO:0048592	144	0.322
circulatory system process	GO:0003013	87	0.298	Mouse
regulation of response to stimulus	GO:0048583	269	0.294	Human Zebrafish Mouse Fly
larval development	GO:0002164	2	0.289	Worm Fly
blood vessel development	GO:0001568	246	0.288	Zebrafish Mouse
negative regulation of biological process	GO:0048519	304	0.279	Human Zebrafish Mouse Fly
cellular protein metabolic process	GO:0044267	129	0.278	Human Mouse
stem cell maintenance	GO:0019827	4	0.274	Fly
positive regulation of gene expression	GO:0010628	71	0.272	Zebrafish
regulation of metabolic process	GO:0019222	359	0.267	Human Zebrafish Mouse Fly
central nervous system development	GO:0007417	387	0.255
dorsal ventral pattern formation	GO:0009953	125	0.252	Zebrafish
regulation of cell communication	GO:0010646	232	0.248	Human Zebrafish Mouse Fly
enzyme linked receptor protein signaling pathway	GO:0007167	106	0.246	Human Zebrafish Mouse Fly
signal transduction	GO:0007165	455	0.243	Human Zebrafish Mouse Fly
negative regulation of kinase activity	GO:0033673	4	0.242
cell part morphogenesis	GO:0032990	246	0.242	Fly
negative regulation of signal transduction	GO:0009968	94	0.239	Human Mouse Fly
positive regulation of cellular metabolic process	GO:0031325	94	0.236	Human Zebrafish
axon development	GO:0061564	166	0.235	Fly
hatching gland development	GO:0048785	3	0.227
negative regulation of bmp signaling pathway	GO:0030514	13	0.226	Human Mouse
positive regulation of nitrogen compound metabolic process	GO:0051173	69	0.225	Zebrafish
regulation of cellular response to growth factor stimulus	GO:0090287	35	0.224	Human Fly
cellular response to organic substance	GO:0071310	105	0.219	Human Mouse Fly
regulation of apoptotic process	GO:0042981	98	0.210
regulation of anatomical structure morphogenesis	GO:0022603	130	0.209	Zebrafish
regulation of neurogenesis	GO:0050767	87	0.209
response to chemical	GO:0042221	320	0.207	Human Mouse Fly
gland development	GO:0048732	143	0.207
camera type eye development	GO:0043010	222	0.206
positive regulation of epithelial cell differentiation	GO:0030858	2	0.200
regulation of developmental process	GO:0050793	247	0.200	Zebrafish Fly
connective tissue development	GO:0061448	99	0.197
nuclear transport	GO:0051169	4	0.197
regulation of cellular metabolic process	GO:0031323	320	0.189	Human Zebrafish Mouse Fly
locomotion	GO:0040011	313	0.188	Zebrafish Fly
retina development in camera type eye	GO:0060041	146	0.184
positive regulation of cellular biosynthetic process	GO:0031328	68	0.183	Zebrafish
heart development	GO:0007507	313	0.179	Zebrafish Mouse
positive regulation of biological process	GO:0048518	253	0.175	Human Zebrafish Mouse
embryonic retina morphogenesis in camera type eye	GO:0060059	22	0.173
macromolecular complex subunit organization	GO:0043933	74	0.169
cell surface receptor signaling pathway	GO:0007166	325	0.168	Human Zebrafish Mouse Fly
ectodermal placode development	GO:0071696	37	0.163	Zebrafish
positive regulation of cellular process	GO:0048522	201	0.161	Human Zebrafish Mouse
neuron projection morphogenesis	GO:0048812	161	0.153	Fly
neuron differentiation	GO:0030182	353	0.152	Fly
negative regulation of macromolecule biosynthetic process	GO:0010558	48	0.149	Human Zebrafish
positive regulation of programmed cell death	GO:0043068	29	0.148
death	GO:0016265	121	0.146
vasculature development	GO:0001944	278	0.144	Zebrafish Mouse
transcription from rna polymerase ii promoter	GO:0006366	80	0.142	Human Zebrafish Fly
blood vessel morphogenesis	GO:0048514	216	0.141	Zebrafish Mouse
immune system process	GO:0002376	241	0.140	Zebrafish
positive regulation of nucleic acid templated transcription	GO:1903508	57	0.139	Zebrafish
regulation of programmed cell death	GO:0043067	101	0.139
embryonic skeletal system development	GO:0048706	97	0.135
negative regulation of cellular metabolic process	GO:0031324	77	0.134	Human Zebrafish Mouse
cell migration	GO:0016477	237	0.133	Zebrafish Fly
otic vesicle formation	GO:0030916	27	0.131	Zebrafish
amine metabolic process	GO:0009308	2	0.131
negative regulation of protein phosphorylation	GO:0001933	4	0.130	Human Mouse
cell projection organization	GO:0030030	284	0.129	Fly
organic cyclic compound biosynthetic process	GO:1901362	223	0.128	Human Zebrafish Fly
muscle structure development	GO:0061061	196	0.127	Mouse Fly
myotube cell development	GO:0014904	35	0.126
regulation of cell proliferation	GO:0042127	37	0.126
positive regulation of macromolecule metabolic process	GO:0010604	93	0.124	Human Zebrafish
skeletal system morphogenesis	GO:0048705	102	0.124
morphogenesis of an epithelium	GO:0002009	333	0.122	Zebrafish Fly
intracellular signal transduction	GO:0035556	85	0.121	Human Zebrafish Fly
neuron development	GO:0048666	262	0.118	Fly
specification of symmetry	GO:0009799	204	0.117	Zebrafish
cellular response to chemical stimulus	GO:0070887	157	0.117	Human Mouse Fly
response to external stimulus	GO:0009605	264	0.116	Worm Fly
generation of neurons	GO:0048699	385	0.116	Fly
embryonic organ development	GO:0048568	381	0.114	Zebrafish
embryonic organ morphogenesis	GO:0048562	274	0.113	Zebrafish
localization of cell	GO:0051674	244	0.112	Zebrafish Fly
negative regulation of cell proliferation	GO:0008285	8	0.110
cell growth	GO:0016049	57	0.110	Fly
muscle tissue development	GO:0060537	110	0.108	Mouse
negative regulation of phosphate metabolic process	GO:0045936	13	0.108	Human Mouse
positive regulation of transcription dna templated	GO:0045893	57	0.107	Zebrafish
gene expression	GO:0010467	252	0.107	Human Zebrafish Fly
angiogenesis	GO:0001525	158	0.107
wnt signaling pathway	GO:0016055	80	0.104
negative regulation of protein kinase activity	GO:0006469	4	0.103
otic vesicle morphogenesis	GO:0071600	34	0.103	Zebrafish
ectodermal placode formation	GO:0060788	26	0.102	Zebrafish
embryonic cranial skeleton morphogenesis	GO:0048701	90	0.101
cartilage development	GO:0051216	96	0.099
protein metabolic process	GO:0019538	183	0.096	Human Mouse
regulation of proteolysis	GO:0030162	24	0.095	Human
protein localization to nucleus	GO:0034504	3	0.093
gastrulation	GO:0007369	208	0.092	Zebrafish
melanocyte differentiation	GO:0030318	26	0.092
retina morphogenesis in camera type eye	GO:0060042	79	0.091
response to organic substance	GO:0010033	153	0.091	Human Mouse Fly
negative regulation of macromolecule metabolic process	GO:0010605	76	0.091	Human Zebrafish Mouse
response to growth factor	GO:0070848	39	0.090	Human Mouse Fly
negative regulation of metabolic process	GO:0009892	86	0.089	Human Zebrafish Mouse
regulation of axonogenesis	GO:0050770	32	0.088
negative regulation of rna metabolic process	GO:0051253	48	0.087	Human Zebrafish
stem cell development	GO:0048864	82	0.086	Fly
negative regulation of transcription from rna polymerase ii promoter	GO:0000122	16	0.085	Human Zebrafish
regulation of transcription from rna polymerase ii promoter	GO:0006357	114	0.083	Human Zebrafish Mouse Fly
response to stress	GO:0006950	263	0.083	Human
enteric nervous system development	GO:0048484	12	0.083
regulation of neuron differentiation	GO:0045664	56	0.082
phosphorylation	GO:0016310	69	0.082	Human Mouse Fly
regulation of signal transduction	GO:0009966	225	0.080	Human Zebrafish Mouse Fly
regulation of catalytic activity	GO:0050790	55	0.079	Human
collagen metabolic process	GO:0032963	2	0.079
hindbrain development	GO:0030902	91	0.079
negative regulation of nitrogen compound metabolic process	GO:0051172	59	0.079	Human Zebrafish
ganglion development	GO:0061548	5	0.076
palate development	GO:0060021	8	0.075	Zebrafish
regulation of cell death	GO:0010941	103	0.075
negative regulation of cell cycle	GO:0045786	14	0.075
negative regulation of developmental process	GO:0051093	65	0.075	Fly
single organism nuclear import	GO:1902593	3	0.074
retina layer formation	GO:0010842	24	0.074
negative regulation of catalytic activity	GO:0043086	21	0.074	Human
positive regulation of apoptotic process	GO:0043065	29	0.073
regulation of nervous system development	GO:0051960	90	0.072	Fly
cell projection morphogenesis	GO:0048858	244	0.071	Fly
apoptotic process	GO:0006915	116	0.070
negative regulation of transcription dna templated	GO:0045892	45	0.069	Human Zebrafish
homeostatic process	GO:0042592	142	0.069
macromolecule modification	GO:0043412	111	0.068	Human Mouse
bmp signaling pathway	GO:0030509	52	0.067	Human Zebrafish Mouse Fly
cellular amine metabolic process	GO:0044106	2	0.066
protein targeting to nucleus	GO:0044744	3	0.066
stem cell differentiation	GO:0048863	117	0.066	Fly
determination of left right symmetry	GO:0007368	179	0.064	Zebrafish
immune response	GO:0006955	28	0.064
somatic stem cell maintenance	GO:0035019	1	0.064
developmental growth	GO:0048589	166	0.063	Fly
cellular component morphogenesis	GO:0032989	336	0.063	Fly
cell proliferation	GO:0008283	80	0.063
primary neural tube formation	GO:0014020	1	0.063
lateral inhibition	GO:0046331	1	0.063
positive regulation of metabolic process	GO:0009893	108	0.062	Human Zebrafish
behavior	GO:0007610	74	0.062	Worm
axon guidance	GO:0007411	86	0.062	Fly
skeletal system development	GO:0001501	181	0.061
signal transduction by p53 class mediator	GO:0072331	13	0.060
regulation of epithelial to mesenchymal transition	GO:0010717	3	0.060
cell morphogenesis	GO:0000902	289	0.060	Fly
regulation of cellular protein metabolic process	GO:0032268	52	0.060	Human Mouse
central nervous system myelin formation	GO:0032289	1	0.060
negative regulation of nucleic acid templated transcription	GO:1903507	45	0.059	Human Zebrafish
cell morphogenesis involved in neuron differentiation	GO:0048667	163	0.059	Fly
nephron morphogenesis	GO:0072028	2	0.059
convergent extension	GO:0060026	118	0.059	Zebrafish
photoreceptor cell differentiation	GO:0046530	55	0.058
cell cycle arrest	GO:0007050	1	0.058
cellular protein catabolic process	GO:0044257	4	0.058	Human
regulation of protein metabolic process	GO:0051246	56	0.057	Human Mouse
positive regulation of rna biosynthetic process	GO:1902680	57	0.056	Zebrafish
hemopoiesis	GO:0030097	183	0.056	Zebrafish
epidermal cell differentiation	GO:0009913	36	0.056
lens morphogenesis in camera type eye	GO:0002089	7	0.055
regulation of canonical wnt signaling pathway	GO:0060828	34	0.055
epidermal cell fate specification	GO:0009957	4	0.054
regulation of biomineral tissue development	GO:0070167	2	0.054
negative regulation of signaling	GO:0023057	96	0.054	Human Mouse Fly
heart morphogenesis	GO:0003007	156	0.054	Zebrafish Mouse
defense response	GO:0006952	47	0.053
regulation of epithelial cell proliferation	GO:0050678	3	0.053
determination of ventral identity	GO:0048264	21	0.053	Zebrafish
neuroblast proliferation	GO:0007405	2	0.053
female gonad development	GO:0008585	4	0.053
central nervous system neuron differentiation	GO:0021953	74	0.052
somite development	GO:0061053	96	0.052
digestive system development	GO:0055123	289	0.052	Zebrafish Fly
regulation of cellular ketone metabolic process	GO:0010565	7	0.051
positive regulation of cell differentiation	GO:0045597	30	0.051	Zebrafish
single organism metabolic process	GO:0044710	217	0.051
cellular response to fibroblast growth factor stimulus	GO:0044344	22	0.051
skin development	GO:0043588	54	0.050
positive regulation of developmental process	GO:0051094	50	0.050	Zebrafish
neural plate regionalization	GO:0060897	10	0.049
skeletal muscle fiber development	GO:0048741	35	0.049
female sex differentiation	GO:0046660	4	0.049
peripheral nervous system development	GO:0007422	55	0.048
regulation of cell shape	GO:0008360	1	0.047
ossification	GO:0001503	23	0.047
hematopoietic or lymphoid organ development	GO:0048534	191	0.047	Zebrafish
growth	GO:0040007	174	0.046	Fly
positive regulation of canonical wnt signaling pathway	GO:0090263	4	0.046
sex determination	GO:0007530	1	0.046
embryonic heart tube development	GO:0035050	133	0.045	Zebrafish
regulation of wnt signaling pathway	GO:0030111	53	0.045
negative regulation of wnt signaling pathway	GO:0030178	30	0.045
regulation of cytokine production	GO:0001817	3	0.045
negative regulation of sequence specific dna binding transcription factor activity	GO:0043433	2	0.044	Human
nucleocytoplasmic transport	GO:0006913	4	0.044
brain morphogenesis	GO:0048854	18	0.043
regulation of signal transduction by p53 class mediator	GO:1901796	9	0.043
protein modification process	GO:0036211	100	0.043	Human Mouse
positive regulation of response to stimulus	GO:0048584	80	0.043
regulation of biological quality	GO:0065008	263	0.043	Human Fly
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090101	22	0.043	Human Mouse Fly
striated muscle tissue development	GO:0014706	110	0.042	Mouse
positive regulation of rna metabolic process	GO:0051254	59	0.042	Zebrafish
neural plate pattern specification	GO:0060896	12	0.041
motor neuron axon guidance	GO:0008045	23	0.041
neuron projection guidance	GO:0097485	86	0.041	Fly
regulation of growth	GO:0040008	42	0.041	Fly
regulation of cell cycle	GO:0051726	52	0.041
regulation of phosphorus metabolic process	GO:0051174	43	0.041	Human Mouse Fly
regulation of cell morphogenesis involved in differentiation	GO:0010769	38	0.040
photoreceptor cell fate commitment	GO:0046552	1	0.040
chemotaxis	GO:0006935	104	0.040	Fly
cell cycle	GO:0007049	93	0.040
regulation of cellular amino acid metabolic process	GO:0006521	0	0.040
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	42	0.039
cell migration involved in gastrulation	GO:0042074	79	0.039	Zebrafish
retinal ganglion cell axon guidance	GO:0031290	35	0.039	Fly
regulation of phosphate metabolic process	GO:0019220	43	0.039	Human Mouse Fly
embryonic eye morphogenesis	GO:0048048	30	0.039
establishment of protein localization to organelle	GO:0072594	4	0.038
neural crest cell differentiation	GO:0014033	72	0.038
sister chromatid cohesion	GO:0007062	2	0.038
protein import into nucleus	GO:0006606	3	0.038
cranial ganglion development	GO:0061550	3	0.037
phosphate containing compound metabolic process	GO:0006796	108	0.037	Human Mouse Fly
negative regulation of apoptotic process	GO:0043066	55	0.037
positive regulation of endothelial cell differentiation	GO:0045603	2	0.037
negative regulation of response to stimulus	GO:0048585	104	0.036	Human Mouse Fly
neuroepithelial cell differentiation	GO:0060563	26	0.036
startle response	GO:0001964	4	0.036
muscle organ development	GO:0007517	101	0.035	Mouse Fly
positive regulation of cellular component biogenesis	GO:0044089	3	0.035
cellular amino acid metabolic process	GO:0006520	7	0.035
cell cycle process	GO:0022402	53	0.035
glucose homeostasis	GO:0042593	1	0.035
cellular response to extracellular stimulus	GO:0031668	2	0.034
gliogenesis	GO:0042063	45	0.034
regulation of organ growth	GO:0046620	3	0.034
epithelial tube morphogenesis	GO:0060562	148	0.034	Zebrafish Fly
determination of bilateral symmetry	GO:0009855	204	0.034	Zebrafish
protein import	GO:0017038	3	0.033
embryonic camera type eye development	GO:0031076	29	0.033
proteolysis involved in cellular protein catabolic process	GO:0051603	3	0.033	Human
regulation of oocyte development	GO:0060281	3	0.033	Zebrafish
nuclear import	GO:0051170	3	0.033
cell cycle g1 s phase transition	GO:0044843	1	0.033
negative regulation of epithelial cell proliferation	GO:0050680	1	0.033
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	48	0.033	Human Zebrafish
cell death	GO:0008219	121	0.032
epithelial cell differentiation	GO:0030855	116	0.032
programmed cell death	GO:0012501	119	0.032
synaptic growth at neuromuscular junction	GO:0051124	2	0.032	Fly
regulation of response to nutrient levels	GO:0032107	1	0.032
meiotic nuclear division	GO:0007126	4	0.031
regulation of chondrocyte differentiation	GO:0032330	1	0.031
fibroblast growth factor receptor signaling pathway	GO:0008543	22	0.031
heart looping	GO:0001947	94	0.031	Zebrafish
positive regulation of signal transduction	GO:0009967	56	0.030
myotube differentiation	GO:0014902	45	0.030
epidermis development	GO:0008544	48	0.030
tube morphogenesis	GO:0035239	349	0.030	Zebrafish Fly
embryonic camera type eye morphogenesis	GO:0048596	19	0.030
determination of heart left right asymmetry	GO:0061371	117	0.030	Zebrafish
blood circulation	GO:0008015	87	0.030	Mouse
negative regulation of chromosome organization	GO:2001251	1	0.030
regulation of cellular carbohydrate metabolic process	GO:0010675	4	0.029
regionalization	GO:0003002	274	0.029	Zebrafish Fly
regulation of cell projection organization	GO:0031344	44	0.028
positive regulation of cellular protein metabolic process	GO:0032270	22	0.028	Human
cellular ketone metabolic process	GO:0042180	11	0.028
regulation of protein binding	GO:0043393	3	0.028
developmental programmed cell death	GO:0010623	4	0.028
regulation of signaling	GO:0023051	235	0.028	Human Zebrafish Mouse Fly
odontogenesis of dentin containing tooth	GO:0042475	1	0.028
lens development in camera type eye	GO:0002088	22	0.027
development of primary female sexual characteristics	GO:0046545	4	0.027
rhythmic process	GO:0048511	21	0.027
synaptic target recognition	GO:0008039	1	0.027
small gtpase mediated signal transduction	GO:0007264	8	0.027
regulation of cellular amine metabolic process	GO:0033238	0	0.027
endoderm development	GO:0007492	49	0.026
developmental cell growth	GO:0048588	52	0.026
chromosome organization	GO:0051276	31	0.026
hepaticobiliary system development	GO:0061008	98	0.026
regulation of mapk cascade	GO:0043408	14	0.025
multicellular organismal metabolic process	GO:0044236	2	0.025
modification dependent macromolecule catabolic process	GO:0043632	3	0.025	Human
cellular response to nutrient levels	GO:0031669	2	0.025
positive regulation of cell communication	GO:0010647	56	0.025
biomineral tissue development	GO:0031214	13	0.025
protein modification by small protein conjugation or removal	GO:0070647	14	0.025	Human
central nervous system myelination	GO:0022010	2	0.025
tube closure	GO:0060606	1	0.025
positive regulation of catabolic process	GO:0009896	4	0.025	Human
fin development	GO:0033333	77	0.025
regulation of erk1 and erk2 cascade	GO:0070372	4	0.024
positive regulation of multicellular organismal process	GO:0051240	52	0.024	Zebrafish
columnar cuboidal epithelial cell differentiation	GO:0002065	38	0.024
response to vitamin	GO:0033273	3	0.024
positive regulation of nucleobase containing compound metabolic process	GO:0045935	69	0.024	Zebrafish
taxis	GO:0042330	109	0.024	Fly
negative regulation of biosynthetic process	GO:0009890	55	0.024	Human Zebrafish
guanosine containing compound catabolic process	GO:1901069	2	0.024
negative regulation of intracellular signal transduction	GO:1902532	22	0.024
urogenital system development	GO:0001655	97	0.024	Mouse Fly
organic acid metabolic process	GO:0006082	31	0.023
regulation of protein modification by small protein conjugation or removal	GO:1903320	3	0.023	Human
neural precursor cell proliferation	GO:0061351	20	0.023
regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090092	50	0.023	Human Zebrafish Mouse Fly
negative regulation of mapk cascade	GO:0043409	4	0.023
proteolysis	GO:0006508	38	0.023	Human
positive regulation of macromolecule biosynthetic process	GO:0010557	59	0.023	Zebrafish
regulation of hydrolase activity	GO:0051336	28	0.022
regulation of kinase activity	GO:0043549	15	0.022
cell substrate adhesion	GO:0031589	4	0.022
stem cell division	GO:0017145	1	0.022
regulation of cell migration	GO:0030334	40	0.022
negative regulation of molecular function	GO:0044092	23	0.022	Human
negative regulation of cell development	GO:0010721	26	0.022
oligodendrocyte development	GO:0014003	7	0.022
positive regulation of cytoskeleton organization	GO:0051495	3	0.022
negative regulation of rna biosynthetic process	GO:1902679	45	0.022	Human Zebrafish
cell fate commitment	GO:0045165	99	0.022
skeletal muscle organ development	GO:0060538	78	0.022
nephron epithelium morphogenesis	GO:0072088	1	0.022
positive regulation of signaling	GO:0023056	56	0.022
regulation of skeletal muscle tissue development	GO:0048641	4	0.021
optic placode formation involved in camera type eye formation	GO:0046619	3	0.021
regulation of establishment of protein localization	GO:0070201	4	0.021
maintenance of location	GO:0051235	4	0.021
fin morphogenesis	GO:0033334	53	0.021
myeloid cell development	GO:0061515	32	0.021	Zebrafish
negative regulation of phosphorylation	GO:0042326	6	0.021	Human Mouse
response to oxygen levels	GO:0070482	25	0.021
regulation of intracellular signal transduction	GO:1902531	57	0.021
axonal defasciculation	GO:0007414	2	0.020
pigmentation	GO:0043473	85	0.020	Worm
regulation of protein complex assembly	GO:0043254	3	0.020
protein acylation	GO:0043543	3	0.020
mitotic cell cycle	GO:0000278	64	0.020
regulation of transferase activity	GO:0051338	16	0.020	Human
regulation of bmp signaling pathway	GO:0030510	39	0.020	Human Zebrafish Mouse
striated muscle cell differentiation	GO:0051146	129	0.020
negative regulation of cell differentiation	GO:0045596	46	0.020	Fly
mesenchyme development	GO:0060485	127	0.020
regulation of peptidyl tyrosine phosphorylation	GO:0050730	1	0.020
multicellular organismal macromolecule metabolic process	GO:0044259	2	0.020
single organism transport	GO:0044765	206	0.019
meiotic cell cycle process	GO:1903046	3	0.019
negative regulation of gene expression	GO:0010629	65	0.019	Human Zebrafish
negative regulation of mitosis	GO:0045839	3	0.019
regulation of cell motility	GO:2000145	46	0.019
ovulation cycle	GO:0042698	2	0.019
positive regulation of chromosome organization	GO:2001252	1	0.019
eye field cell fate commitment involved in camera type eye formation	GO:0060898	3	0.019
developmental growth involved in morphogenesis	GO:0060560	86	0.019	Fly
renal tubule morphogenesis	GO:0061333	1	0.019	Fly
regulation of endothelial cell differentiation	GO:0045601	3	0.019
cellular response to endogenous stimulus	GO:0071495	68	0.019	Human Mouse Fly
embryonic viscerocranium morphogenesis	GO:0048703	52	0.019
stem cell proliferation	GO:0072089	4	0.019
regulation of cytoplasmic transport	GO:1903649	4	0.019
carboxylic acid metabolic process	GO:0019752	22	0.019
protein destabilization	GO:0031648	1	0.019
forebrain neuron fate commitment	GO:0021877	1	0.019
otic vesicle development	GO:0071599	42	0.019	Zebrafish
negative regulation of protein serine threonine kinase activity	GO:0071901	2	0.018
covalent chromatin modification	GO:0016569	20	0.018
notch signaling pathway	GO:0007219	35	0.018
immune system development	GO:0002520	191	0.018	Zebrafish
adult behavior	GO:0030534	2	0.018
positive regulation of cell death	GO:0010942	29	0.018
mesenchymal cell development	GO:0014031	78	0.018
negative regulation of cell cycle process	GO:0010948	9	0.018
regulation of histone deacetylation	GO:0031063	2	0.018
regulation of vascular permeability	GO:0043114	5	0.018
regulation of bone mineralization	GO:0030500	2	0.017
convergent extension involved in gastrulation	GO:0060027	71	0.017	Zebrafish
positive regulation of immune system process	GO:0002684	17	0.017
phosphatidylinositol 3 kinase signaling	GO:0014065	2	0.017
regulation of organ morphogenesis	GO:2000027	35	0.017	Zebrafish
meiosis i	GO:0007127	1	0.017
eye photoreceptor cell development	GO:0042462	30	0.017
regulation of protein transport	GO:0051223	3	0.017
response to abiotic stimulus	GO:0009628	122	0.017
regulation of muscle organ development	GO:0048634	9	0.017	Fly
appendage development	GO:0048736	80	0.017	Fly
histone deacetylation	GO:0016575	2	0.017
neurological system process	GO:0050877	62	0.017
erk1 and erk2 cascade	GO:0070371	4	0.017
cellular modified amino acid metabolic process	GO:0006575	3	0.017
macromolecule catabolic process	GO:0009057	15	0.017	Human
smoothened signaling pathway	GO:0007224	30	0.017
negative regulation of map kinase activity	GO:0043407	2	0.017
positive regulation of neurogenesis	GO:0050769	24	0.016
positive regulation of protein metabolic process	GO:0051247	23	0.016	Human
regulation of ossification	GO:0030278	5	0.016
chromatin organization	GO:0006325	22	0.016
extrinsic apoptotic signaling pathway	GO:0097191	3	0.016
regulation of phosphorylation	GO:0042325	26	0.016	Human Mouse Fly
bone morphogenesis	GO:0060349	11	0.016
regulation of system process	GO:0044057	40	0.016	Mouse
digestive tract development	GO:0048565	265	0.016	Zebrafish Fly
regulation of cellular component organization	GO:0051128	86	0.016	Fly
regulation of skeletal muscle fiber development	GO:0048742	2	0.016
regulation of gastrulation	GO:0010470	24	0.016
regulation of carbohydrate metabolic process	GO:0006109	4	0.016
negative regulation of programmed cell death	GO:0043069	58	0.015
regulation of localization	GO:0032879	104	0.015
nephron tubule morphogenesis	GO:0072078	1	0.015
regulation of nucleocytoplasmic transport	GO:0046822	2	0.015
endothelial cell migration	GO:0043542	19	0.015
embryonic skeletal system morphogenesis	GO:0048704	93	0.015
regulation of protein import into nucleus	GO:0042306	2	0.015
positive regulation of apoptotic signaling pathway	GO:2001235	1	0.015
positive regulation of cell cycle	GO:0045787	3	0.015
cellular localization	GO:0051641	97	0.015	Human
positive regulation of glial cell differentiation	GO:0045687	1	0.015
embryonic limb morphogenesis	GO:0030326	2	0.015
negative regulation of mitotic cell cycle	GO:0045930	11	0.015
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	22	0.015
nose development	GO:0043584	3	0.015

smad7 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease	DO term ID	Probability
dysostosis	DOID:1934	0.022
bone disease	DOID:0080001	0.022
bone development disease	DOID:0080006	0.022
disease of anatomical entity	DOID:7	0.022
connective tissue disease	DOID:65	0.022
musculoskeletal system disease	DOID:17	0.022

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