IMP: Integrative Multi-species Prediction

Danio rerio

0 known processes

tomm40l

translocase of outer mitochondrial membrane 40 homolog, like

(Aliases: zgc:85715,MGC85715)

ZFIN: ZDB-GENE-040426-2319
Entrez: 405895
Ensembl: ENSDARG00000036721
UniProtKB: Q6NWH3

Process Predictions
Disease Predictions

tomm40l biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
larval development	GO:0002164	2	0.867	Worm
single organism organelle organization	GO:1902589	199	0.237
single organism metabolic process	GO:0044710	217	0.148
cellular component morphogenesis	GO:0032989	336	0.147
regulation of multicellular organism growth	GO:0040014	4	0.128	Worm
aging	GO:0007568	2	0.124
establishment of localization	GO:0051234	244	0.107	Human Worm
positive regulation of biological process	GO:0048518	253	0.107	Worm
spindle assembly	GO:0051225	2	0.099
negative regulation of cellular process	GO:0048523	283	0.097
nucleobase containing compound biosynthetic process	GO:0034654	205	0.095
signal transduction	GO:0007165	455	0.092
mitochondrion organization	GO:0007005	4	0.091	Human
protein metabolic process	GO:0019538	183	0.090
biosynthetic process	GO:0009058	294	0.086
cellular macromolecule metabolic process	GO:0044260	391	0.083
multicellular organism growth	GO:0035264	4	0.082	Worm
organelle organization	GO:0006996	227	0.080	Human
cellular protein metabolic process	GO:0044267	129	0.076
heterocycle biosynthetic process	GO:0018130	215	0.072
regulation of developmental process	GO:0050793	247	0.071	Worm
response to stress	GO:0006950	263	0.069
protein acetylation	GO:0006473	2	0.069
embryo development ending in birth or egg hatching	GO:0009792	271	0.069	Worm
protein complex assembly	GO:0006461	30	0.067
regulation of response to stimulus	GO:0048583	269	0.067
transport	GO:0006810	220	0.066	Human Worm
regulation of myotube differentiation	GO:0010830	2	0.066
gene expression	GO:0010467	252	0.064
negative regulation of biological process	GO:0048519	304	0.062
cellular biosynthetic process	GO:0044249	286	0.060
regulation of gene expression	GO:0010468	265	0.059
response to chemical	GO:0042221	320	0.058
cellular localization	GO:0051641	97	0.058	Human Worm
morphogenesis of an epithelium	GO:0002009	333	0.057
regulation of signaling	GO:0023051	235	0.057
nucleic acid templated transcription	GO:0097659	181	0.056
post embryonic morphogenesis	GO:0009886	4	0.055
cellular component biogenesis	GO:0044085	178	0.053
regulation of cell communication	GO:0010646	232	0.053
determination of left right symmetry	GO:0007368	179	0.052
death	GO:0016265	121	0.051	Worm
protein complex subunit organization	GO:0071822	46	0.051
regulation of macromolecule metabolic process	GO:0060255	317	0.051
rna biosynthetic process	GO:0032774	181	0.050
organic cyclic compound biosynthetic process	GO:1901362	223	0.048
regulation of rna biosynthetic process	GO:2001141	213	0.048
establishment of protein localization to organelle	GO:0072594	4	0.048	Human
lipid storage	GO:0019915	1	0.048
determination of bilateral symmetry	GO:0009855	204	0.046
regulation of multicellular organismal process	GO:0051239	277	0.045	Worm
cellular component assembly	GO:0022607	170	0.045
organic substance biosynthetic process	GO:1901576	289	0.044
vasculature development	GO:0001944	278	0.044
rna metabolic process	GO:0016070	219	0.044
maintenance of location	GO:0051235	4	0.043
single organism reproductive process	GO:0044702	40	0.043	Worm
regulation of cell differentiation	GO:0045595	142	0.041
small molecule metabolic process	GO:0044281	77	0.040
digestive system development	GO:0055123	289	0.040
cellular protein modification process	GO:0006464	100	0.040
cellular component assembly involved in morphogenesis	GO:0010927	107	0.038
nitrogen compound metabolic process	GO:0006807	319	0.038
regulation of transcription from rna polymerase ii promoter	GO:0006357	114	0.038
striated muscle cell differentiation	GO:0051146	129	0.037
single organism localization	GO:1902578	225	0.037	Human Worm
regulation of multicellular organismal development	GO:2000026	223	0.037
purine nucleotide biosynthetic process	GO:0006164	20	0.037
cellular nitrogen compound biosynthetic process	GO:0044271	218	0.037
multi organism process	GO:0051704	134	0.036
positive regulation of translation	GO:0045727	1	0.036
stem cell differentiation	GO:0048863	117	0.036
specification of symmetry	GO:0009799	204	0.036
regulation of primary metabolic process	GO:0080090	311	0.035
microtubule cytoskeleton organization involved in mitosis	GO:1902850	1	0.035
macromolecule biosynthetic process	GO:0009059	227	0.034
cell death	GO:0008219	121	0.033	Worm
cellular macromolecule biosynthetic process	GO:0034645	224	0.033
protein acylation	GO:0043543	3	0.032
spermatid development	GO:0007286	2	0.032
stem cell maintenance	GO:0019827	4	0.031
cell migration	GO:0016477	237	0.031	Worm
ribonucleoside monophosphate catabolic process	GO:0009158	4	0.031
digestive tract development	GO:0048565	265	0.031
negative regulation of gene expression	GO:0010629	65	0.029
embryonic digestive tract development	GO:0048566	4	0.028
reproduction	GO:0000003	40	0.027	Worm
regulation of biological quality	GO:0065008	263	0.027
regulation of metabolic process	GO:0019222	359	0.027
determination of heart left right asymmetry	GO:0061371	117	0.027
regulation of skeletal muscle tissue development	GO:0048641	4	0.027
embryonic digestive tract morphogenesis	GO:0048557	3	0.027
regulation of cell development	GO:0060284	100	0.026
tube morphogenesis	GO:0035239	349	0.026
regulation of cellular metabolic process	GO:0031323	320	0.026
protein modification process	GO:0036211	100	0.026
cell motility	GO:0048870	244	0.026	Worm
negative regulation of cell death	GO:0060548	60	0.026
stem cell proliferation	GO:0072089	4	0.026
spindle assembly involved in mitosis	GO:0090307	1	0.025
macromolecular complex assembly	GO:0065003	35	0.025
macromolecule methylation	GO:0043414	19	0.025
cell aging	GO:0007569	2	0.024
negative regulation of developmental process	GO:0051093	65	0.024
covalent chromatin modification	GO:0016569	20	0.024
oxoacid metabolic process	GO:0043436	31	0.024
reproductive process	GO:0022414	40	0.024	Worm
nucleoside phosphate biosynthetic process	GO:1901293	21	0.023
negative regulation of macromolecule metabolic process	GO:0010605	76	0.023
sexual reproduction	GO:0019953	36	0.023
internal peptidyl lysine acetylation	GO:0018393	2	0.022
protein complex biogenesis	GO:0070271	30	0.022
cell surface receptor signaling pathway	GO:0007166	325	0.022
internal protein amino acid acetylation	GO:0006475	2	0.022
transmembrane transport	GO:0055085	120	0.022
organelle assembly	GO:0070925	110	0.022
synaptic growth at neuromuscular junction	GO:0051124	2	0.021
single fertilization	GO:0007338	3	0.021
developmental growth	GO:0048589	166	0.021	Worm
macromolecular complex subunit organization	GO:0043933	74	0.021
cell proliferation	GO:0008283	80	0.021
organophosphate biosynthetic process	GO:0090407	23	0.021
adult behavior	GO:0030534	2	0.021
establishment of localization in cell	GO:0051649	77	0.021	Human Worm
neuron development	GO:0048666	262	0.020
cell cell recognition	GO:0009988	1	0.020
regulation of programmed cell death	GO:0043067	101	0.020
regulation of skeletal muscle fiber development	GO:0048742	2	0.020
regulation of macromolecule biosynthetic process	GO:0010556	225	0.020
apoptotic process	GO:0006915	116	0.020	Worm
positive regulation of cell cycle	GO:0045787	3	0.020
liver development	GO:0001889	96	0.020
neuron projection morphogenesis	GO:0048812	161	0.019
generation of neurons	GO:0048699	385	0.019
transcription from rna polymerase ii promoter	GO:0006366	80	0.019
negative regulation of protein phosphorylation	GO:0001933	4	0.019
positive regulation of developmental process	GO:0051094	50	0.019	Worm
negative regulation of metabolic process	GO:0009892	86	0.019
organonitrogen compound metabolic process	GO:1901564	74	0.019
positive regulation of response to stimulus	GO:0048584	80	0.019
regulation of i kappab kinase nf kappab signaling	GO:0043122	4	0.019
epithelial tube morphogenesis	GO:0060562	148	0.019
macromolecule deacylation	GO:0098732	3	0.019
amine metabolic process	GO:0009308	2	0.019
cellular nitrogen compound metabolic process	GO:0034641	290	0.019
regulation of cell death	GO:0010941	103	0.019
i kappab kinase nf kappab signaling	GO:0007249	4	0.018
pyrimidine containing compound metabolic process	GO:0072527	3	0.018
cellular component disassembly	GO:0022411	1	0.018
nuclear transport	GO:0051169	4	0.018
response to drug	GO:0042493	3	0.018
muscle structure development	GO:0061061	196	0.018
microtubule based process	GO:0007017	60	0.018
interspecies interaction between organisms	GO:0044419	4	0.018
regulation of transcription dna templated	GO:0006355	213	0.018
enzyme linked receptor protein signaling pathway	GO:0007167	106	0.018
b cell activation	GO:0042113	2	0.018
camera type eye development	GO:0043010	222	0.018
negative regulation of signal transduction	GO:0009968	94	0.018
positive regulation of cytosolic calcium ion concentration	GO:0007204	4	0.018
positive regulation of canonical wnt signaling pathway	GO:0090263	4	0.017
purine ribonucleoside monophosphate catabolic process	GO:0009169	4	0.017
heart contraction	GO:0060047	71	0.017
translational initiation	GO:0006413	3	0.017
mitochondrial transport	GO:0006839	2	0.017	Human
nucleoside monophosphate catabolic process	GO:0009125	4	0.017
response to organic substance	GO:0010033	153	0.017
regulation of intracellular signal transduction	GO:1902531	57	0.017
growth	GO:0040007	174	0.017	Worm
spermatid differentiation	GO:0048515	2	0.017
macromolecule localization	GO:0033036	54	0.017	Human Worm
response to topologically incorrect protein	GO:0035966	2	0.017
cellular response to chemical stimulus	GO:0070887	157	0.017
carboxylic acid metabolic process	GO:0019752	22	0.017
positive regulation of cytoskeleton organization	GO:0051495	3	0.017
nucleic acid metabolic process	GO:0090304	244	0.017
tissue remodeling	GO:0048771	4	0.017
germ line stem cell maintenance	GO:0030718	2	0.017
ribonucleoside biosynthetic process	GO:0042455	2	0.016
regulation of synapse organization	GO:0050807	3	0.016
cellular component movement	GO:0006928	335	0.016	Worm
ion transmembrane transport	GO:0034220	91	0.016
system process	GO:0003008	185	0.016
dna catabolic process	GO:0006308	1	0.016
cellular response to dsrna	GO:0071359	1	0.016
muscle fiber development	GO:0048747	52	0.016
digestive tract morphogenesis	GO:0048546	231	0.016
heart development	GO:0007507	313	0.016
peptidyl lysine acetylation	GO:0018394	2	0.016
organic cyclic compound metabolic process	GO:1901360	301	0.016
regulation of cell cycle process	GO:0010564	20	0.016
immune system process	GO:0002376	241	0.016
embryonic organ morphogenesis	GO:0048562	274	0.016
aromatic compound biosynthetic process	GO:0019438	217	0.016
cell part morphogenesis	GO:0032990	246	0.016
protein import	GO:0017038	3	0.016
sensory organ development	GO:0007423	393	0.016
negative regulation of cell differentiation	GO:0045596	46	0.016
myotube cell development	GO:0014904	35	0.015
positive regulation of biosynthetic process	GO:0009891	68	0.015
eye development	GO:0001654	277	0.015
histone modification	GO:0016570	20	0.015
cellular response to stress	GO:0033554	62	0.015
nucleoside triphosphate biosynthetic process	GO:0009142	2	0.015
gamete generation	GO:0007276	33	0.015
mononuclear cell proliferation	GO:0032943	1	0.015
heart morphogenesis	GO:0003007	156	0.015
organic acid metabolic process	GO:0006082	31	0.015
regulation of organelle assembly	GO:1902115	4	0.015
compound eye development	GO:0048749	2	0.015
response to wounding	GO:0009611	116	0.015
phosphorylation	GO:0016310	69	0.015
regulation of rna metabolic process	GO:0051252	224	0.015
negative regulation of programmed cell death	GO:0043069	58	0.014
gland development	GO:0048732	143	0.014
neurotransmitter transport	GO:0006836	2	0.014
regulation of nucleic acid templated transcription	GO:1903506	213	0.014
regulation of biosynthetic process	GO:0009889	250	0.014
cell projection organization	GO:0030030	284	0.014
muscle tissue development	GO:0060537	110	0.014
mesoderm development	GO:0007498	88	0.014
lipid homeostasis	GO:0055088	3	0.014
positive regulation of transport	GO:0051050	2	0.014
embryonic limb morphogenesis	GO:0030326	2	0.014
axon guidance	GO:0007411	86	0.014
regulation of cellular ketone metabolic process	GO:0010565	7	0.014
negative regulation of rna splicing	GO:0033119	1	0.014
zymogen activation	GO:0031638	3	0.014
phosphorus metabolic process	GO:0006793	109	0.013
intracellular receptor signaling pathway	GO:0030522	30	0.013
negative regulation of multicellular organismal process	GO:0051241	69	0.013
regulation of nucleobase containing compound metabolic process	GO:0019219	250	0.013
protein complex disassembly	GO:0043241	1	0.013
positive regulation of cellular catabolic process	GO:0031331	3	0.013
pyrimidine nucleotide metabolic process	GO:0006220	1	0.013
cytoskeleton organization	GO:0007010	96	0.013
embryonic organ development	GO:0048568	381	0.013
neuron projection development	GO:0031175	180	0.013
heart looping	GO:0001947	94	0.013
macromolecule modification	GO:0043412	111	0.013
angiogenesis	GO:0001525	158	0.013
programmed cell death	GO:0012501	119	0.013	Worm
mitotic cell cycle	GO:0000278	64	0.013
cellular process involved in reproduction in multicellular organism	GO:0022412	28	0.012
negative regulation of cellular metabolic process	GO:0031324	77	0.012
dna templated transcription elongation	GO:0006354	3	0.012
fertilization	GO:0009566	3	0.012
developmental process involved in reproduction	GO:0003006	27	0.012	Worm
regulation of cell cycle	GO:0051726	52	0.012
multicellular organismal reproductive process	GO:0048609	35	0.012
regulation of intracellular protein transport	GO:0033157	3	0.012
regulation of ion transmembrane transporter activity	GO:0032412	2	0.012
multicellular organism reproduction	GO:0032504	35	0.012
mesenchyme development	GO:0060485	127	0.012
regulation of developmental growth	GO:0048638	38	0.012	Worm
cellular amine metabolic process	GO:0044106	2	0.012
cellular aromatic compound metabolic process	GO:0006725	295	0.012
macromolecular complex disassembly	GO:0032984	1	0.012
positive regulation of chromosome organization	GO:2001252	1	0.012
regulation of signal transduction	GO:0009966	225	0.012
regulation of nitrogen compound metabolic process	GO:0051171	251	0.012
regulation of nucleoside metabolic process	GO:0009118	2	0.012
production of molecular mediator of immune response	GO:0002440	2	0.012
renal system development	GO:0072001	94	0.011
striated muscle cell development	GO:0055002	108	0.011
regulation of growth	GO:0040008	42	0.011	Worm
gastrulation	GO:0007369	208	0.011
meiotic chromosome segregation	GO:0045132	3	0.011
single organism biosynthetic process	GO:0044711	71	0.011
regulation of striated muscle cell differentiation	GO:0051153	6	0.011
response to nutrient	GO:0007584	3	0.011
stem cell development	GO:0048864	82	0.011
astrocyte differentiation	GO:0048708	1	0.011
positive regulation of dna metabolic process	GO:0051054	1	0.011
histone deacetylation	GO:0016575	2	0.011
nuclear division	GO:0000280	23	0.011
negative regulation of kinase activity	GO:0033673	4	0.011
cell morphogenesis involved in neuron differentiation	GO:0048667	163	0.011
negative regulation of nitrogen compound metabolic process	GO:0051172	59	0.011
regulation of cytoplasmic transport	GO:1903649	4	0.011
regulation of mitotic cell cycle	GO:0007346	25	0.011
nucleoside biosynthetic process	GO:0009163	2	0.011
endoplasmic reticulum unfolded protein response	GO:0030968	2	0.011
pancreas development	GO:0031016	84	0.011
regulation of microtubule cytoskeleton organization	GO:0070507	3	0.011
cellular protein complex assembly	GO:0043623	19	0.011
nucleocytoplasmic transport	GO:0006913	4	0.011
positive regulation of cellular component biogenesis	GO:0044089	3	0.011
lipid oxidation	GO:0034440	1	0.010
negative regulation of response to stimulus	GO:0048585	104	0.010
negative regulation of signaling	GO:0023057	96	0.010
positive regulation of leukocyte mediated immunity	GO:0002705	1	0.010
cellular homeostasis	GO:0019725	26	0.010
negative regulation of myeloid cell differentiation	GO:0045638	1	0.010
negative regulation of activin receptor signaling pathway	GO:0032926	5	0.010
cell substrate adhesion	GO:0031589	4	0.010
heterocycle metabolic process	GO:0046483	290	0.010
positive regulation of immune effector process	GO:0002699	3	0.010
nucleotide biosynthetic process	GO:0009165	21	0.010
oocyte maturation	GO:0001556	4	0.010
cellular response to oxygen levels	GO:0071453	1	0.010
response to unfolded protein	GO:0006986	2	0.010
positive regulation of chromatin modification	GO:1903310	1	0.010
protein complex localization	GO:0031503	1	0.010
central nervous system development	GO:0007417	387	0.010
nucleic acid transport	GO:0050657	2	0.010
regulation of transcription from rna polymerase ii promoter involved in determination of left right symmetry	GO:1900094	17	0.010

tomm40l disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.074
disease of cellular proliferation	DOID:14566	0.039
organ system cancer	DOID:0050686	0.039
cancer	DOID:162	0.039
nervous system disease	DOID:863	0.025
sensory system disease	DOID:0050155	0.017
eye disease	DOID:5614	0.017
eye and adnexa disease	DOID:1492	0.017
muscular disease	DOID:0080000	0.011
musculoskeletal system disease	DOID:17	0.011

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