Danio rerio

0 known processes

lrp6

low-density lipoprotein receptor-related protein 6

lrp6 biological process predictions


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Biological processGO term IDProcess sizeProbabilityFunc Analog Org
sensory organ developmentGO:00074233930.095
stem cell proliferationGO:007208940.076
posterior lateral line system developmentGO:0048915460.066
lateral line developmentGO:0048882660.063
mechanosensory lateral line system developmentGO:0048881490.063
neuromast developmentGO:0048884460.062
regulation of stem cell proliferationGO:007209120.059
lipid homeostasisGO:005508830.053
larval developmentGO:000216420.051
posterior lateral line developmentGO:0048916380.050
regulation of blood pressureGO:000821710.049
regulation of nitrogen compound metabolic processGO:00511712510.045
gtp catabolic processGO:000618420.041
sensory system developmentGO:0048880760.040
regulation of multicellular organismal processGO:00512392770.040
negative regulation of protein phosphorylationGO:000193340.038
cellular component movementGO:00069283350.038
negative regulation of cellular processGO:00485232830.037
phagocytosisGO:000690930.037
nitrogen compound metabolic processGO:00068073190.035
eye developmentGO:00016542770.034
response to chemicalGO:00422213200.034
cell surface receptor signaling pathwayGO:00071663250.033
regionalizationGO:00030022740.033
stem cell maintenanceGO:001982740.032
regulation of reproductive processGO:200024140.032
blood vessel developmentGO:00015682460.031
signal transductionGO:00071654550.031
central nervous system developmentGO:00074173870.031
cellular macromolecule metabolic processGO:00442603910.031
positive regulation of cell cycleGO:004578730.030
organic substance biosynthetic processGO:19015762890.030
organic cyclic compound metabolic processGO:19013603010.030
generation of neuronsGO:00486993850.029
lateral line system developmentGO:0048925760.029
retina development in camera type eyeGO:00600411460.028
positive regulation of transportGO:005105020.028
sensory perception of chemical stimulusGO:000760630.027
vasculature developmentGO:00019442780.027
neuroblast proliferationGO:000740520.027
regulation of gene expressionGO:00104682650.027
multicellular organism growthGO:003526440.027
negative regulation of biological processGO:00485193040.027
regulation of primary metabolic processGO:00800903110.027
guanosine containing compound metabolic processGO:190106840.026
system processGO:00030081850.026
extrinsic apoptotic signaling pathwayGO:009719130.026
regulation of multicellular organism growthGO:004001440.026
olfactory lobe developmentGO:002198840.025
cellular nitrogen compound metabolic processGO:00346412900.025
cellular component morphogenesisGO:00329893360.025
guanosine containing compound catabolic processGO:190106920.025
regulation of metal ion transportGO:001095940.024
cellular ketone metabolic processGO:0042180110.024
regulation of stem cell differentiationGO:200073640.024
neuron neuron synaptic transmissionGO:000727010.024
regulation of cellular metabolic processGO:00313233200.024
regulation of biological qualityGO:00650082630.023
positive regulation of stem cell proliferationGO:200064810.023
organic cyclic compound biosynthetic processGO:19013622230.023
peptidyl lysine acetylationGO:001839420.023
neuron differentiationGO:00301823530.023
internal peptidyl lysine acetylationGO:001839320.023
maintenance of locationGO:005123540.023
regulation of cytokine productionGO:000181730.023
cellular response to molecule of bacterial originGO:007121930.022
locomotionGO:00400113130.022
nucleic acid templated transcriptionGO:00976591810.022
regulation of mrna processingGO:005068430.022
hormone secretionGO:004687920.022
regulation of biosynthetic processGO:00098892500.022
cell part morphogenesisGO:00329902460.022
single organism metabolic processGO:00447102170.022
olfactory bulb developmentGO:002177240.022
regulation of macromolecule metabolic processGO:00602553170.022
regulation of cellular ketone metabolic processGO:001056570.022
gtp metabolic processGO:004603940.022
somatic stem cell maintenanceGO:003501910.022
establishment of protein localization to organelleGO:007259440.022
eye morphogenesisGO:00485921440.021
internal protein amino acid acetylationGO:000647520.021
cellular response to external stimulusGO:007149620.021
dorsal ventral pattern formationGO:00099531250.021
lipid storageGO:001991510.021
organonitrogen compound metabolic processGO:1901564740.021
mononuclear cell proliferationGO:003294310.021
camera type eye developmentGO:00430102220.021
homeostasis of number of cells within a tissueGO:004887340.021
cellular biosynthetic processGO:00442492860.020
cellular response to lipopolysaccharideGO:007122230.020
heterocycle metabolic processGO:00464832900.020
cellular aromatic compound metabolic processGO:00067252950.020
hypothalamus cell differentiationGO:002197940.020
sensory organ morphogenesisGO:00905962000.020
posterior lateral line neuromast developmentGO:0048919200.020
amine metabolic processGO:000930820.020
protein importGO:001703830.020
negative regulation of protein serine threonine kinase activityGO:007190120.020
rna biosynthetic processGO:00327741810.020
gene expressionGO:00104672520.020
heterocycle biosynthetic processGO:00181302150.020
biosynthetic processGO:00090582940.019
organelle organizationGO:00069962270.019
nucleic acid metabolic processGO:00903042440.019
cellular macromolecule biosynthetic processGO:00346452240.019
macromolecule biosynthetic processGO:00090592270.019
response to external stimulusGO:00096052640.019
cellular response to biotic stimulusGO:007121630.019
nucleobase containing compound metabolic processGO:00061392740.019
negative regulation of kinase activityGO:003367340.019
cell morphogenesisGO:00009022890.018
regulation of signalingGO:00230512350.018
regulation of developmental processGO:00507932470.018
regulation of purine nucleotide catabolic processGO:003312120.018
regulation of signal transductionGO:00099662250.018
cellular component disassemblyGO:002241110.018
brain developmentGO:00074202930.018
peptide transportGO:001583310.018
secondary metabolic processGO:001974830.018
protein acylationGO:004354330.018
segmentationGO:0035282970.018
cellular nitrogen compound biosynthetic processGO:00442712180.018
regulation of synapse assemblyGO:005196330.018
retina morphogenesis in camera type eyeGO:0060042790.018
cell morphogenesis involved in differentiationGO:00009041950.018
negative regulation of chemotaxisGO:005092240.018
small molecule metabolic processGO:0044281770.018
regulation of cellular biosynthetic processGO:00313262450.017
cellular protein catabolic processGO:004425740.017
regulation of epithelial cell proliferationGO:005067830.017
protein acetylationGO:000647320.017
agingGO:000756820.017
cellular response to nutrient levelsGO:003166920.017
skeletal system developmentGO:00015011810.017
regulation of synaptic growth at neuromuscular junctionGO:000858210.017
regulation of cellular amine metabolic processGO:003323800.017
cell projection organizationGO:00300302840.017
cell motilityGO:00488702440.017
liver developmentGO:0001889960.017
regulation of meiotic cell cycleGO:005144510.017
head developmentGO:00603223030.017
hormone transportGO:000991420.017
regulation of rna metabolic processGO:00512522240.017
regulation of nucleoside metabolic processGO:000911820.017
regulation of response to stimulusGO:00485832690.017
nucleobase containing compound biosynthetic processGO:00346542050.017
ribonucleoside monophosphate catabolic processGO:000915840.017
protein localization to nucleusGO:003450430.017
response to carbohydrateGO:000974330.017
i kappab kinase nf kappab signalingGO:000724940.017
regulation of peptidyl tyrosine phosphorylationGO:005073010.017
cellular amine metabolic processGO:004410620.017
cellular carbohydrate metabolic processGO:004426240.017
somite developmentGO:0061053960.017
development of primary female sexual characteristicsGO:004654540.017
single fertilizationGO:000733830.017
regulation of extrinsic apoptotic signaling pathwayGO:200123630.016
chemosensory behaviorGO:000763510.016
stem cell divisionGO:001714510.016
negative regulation of sequestering of calcium ionGO:005128340.016
somatic cell dna recombinationGO:001644410.016
anterior posterior pattern specificationGO:00099521520.016
synaptic growth at neuromuscular junctionGO:005112420.016
protein import into nucleusGO:000660630.016
organic acid metabolic processGO:0006082310.016
canonical wnt signaling pathwayGO:0060070480.016
single organism nuclear importGO:190259330.016
hepaticobiliary system developmentGO:0061008980.016
positive regulation of catabolic processGO:000989640.016
positive regulation of cytoskeleton organizationGO:005149530.016
response to hexoseGO:000974630.016
cellular response to extracellular stimulusGO:003166820.016
response to monosaccharideGO:003428430.016
response to drugGO:004249330.016
leukocyte proliferationGO:007066110.016
tissue remodelingGO:004877140.016
regulation of sodium ion transportGO:000202820.016
regulation of cell communicationGO:00106462320.015
transcription dna templatedGO:00063511810.015
regulation of nucleotide catabolic processGO:003081120.015
modification dependent protein catabolic processGO:001994130.015
regulation of carbohydrate metabolic processGO:000610940.015
regulation of gtp catabolic processGO:003312420.015
carboxylic acid metabolic processGO:0019752220.015
regulation of hormone secretionGO:004688320.015
regulation of metabolic processGO:00192223590.015
positive regulation of cellular component biogenesisGO:004408930.015
establishment of localizationGO:00512342440.015
carbohydrate biosynthetic processGO:001605110.015
regulation of establishment of protein localizationGO:007020140.015
nucleocytoplasmic transportGO:000691340.015
localization of cellGO:00516742440.015
regulation of nucleic acid templated transcriptionGO:19035062130.015
cell projection morphogenesisGO:00488582440.015
fertilizationGO:000956630.015
sequestering of calcium ionGO:005120830.015
regulation of macromolecule biosynthetic processGO:00105562250.015
positive regulation of reproductive processGO:200024320.015
pharyngeal muscle developmentGO:004328240.015
neurotransmitter transportGO:000683620.015
regulation of gtpase activityGO:004308720.015
positive regulation of secretionGO:005104710.015
digestive system developmentGO:00551232890.015
nuclear transportGO:005116940.015
posterior lateral line neuromast depositionGO:004892250.015
chordate embryonic developmentGO:00430092710.015
regulation of nucleobase containing compound metabolic processGO:00192192500.015
positive regulation of cellular catabolic processGO:003133130.015
aromatic compound biosynthetic processGO:00194382170.015
regulation of blood vessel sizeGO:005088020.015
camera type eye morphogenesisGO:00485931080.014
neuromast primordium migrationGO:0048883120.014
adherens junction organizationGO:003433240.014
regulation of cytoplasmic transportGO:190364940.014
proteasomal protein catabolic processGO:001049820.014
macromolecular complex disassemblyGO:003298410.014
morphogenesis of an epitheliumGO:00020093330.014
immune system developmentGO:00025201910.014
regulation of alternative mrna splicing via spliceosomeGO:000038110.014
angiogenesisGO:00015251580.014
positive regulation of mesenchymal cell proliferationGO:000205310.014
compound eye developmentGO:004874920.014
blood vessel morphogenesisGO:00485142160.014
purine ribonucleoside monophosphate catabolic processGO:000916940.014
sequestering of metal ionGO:005123830.014
protein dephosphorylationGO:000647030.014
rna metabolic processGO:00160702190.014
membrane fusionGO:006102520.014
female gonad developmentGO:000858540.014
carbohydrate homeostasisGO:003350010.014
embryonic organ morphogenesisGO:00485622740.014
regulation of protein catabolic processGO:004217610.014
positive regulation of cytosolic calcium ion concentrationGO:000720440.014
adult behaviorGO:003053420.014
embryonic organ developmentGO:00485683810.014
regulation of phGO:000688530.014
regulation of muscle contractionGO:000693730.014
positive regulation of cytokine productionGO:000181920.014
cellular response to starvationGO:000926710.014
tube morphogenesisGO:00352393490.013
macromolecule modificationGO:00434121110.013
regulation of cellular macromolecule biosynthetic processGO:20001122220.013
protein localization to plasma membraneGO:007265910.013
regulation of cellular amino acid metabolic processGO:000652100.013
neuron developmentGO:00486662620.013
regulation of mrna splicing via spliceosomeGO:004802430.013
taxisGO:00423301090.013
immune system processGO:00023762410.013
membrane invaginationGO:001032410.013
autophagyGO:000691440.013
proteolysis involved in cellular protein catabolic processGO:005160330.013
positive regulation of apoptotic signaling pathwayGO:200123510.013
positive regulation of secretion by cellGO:190353210.013
muscle fiber developmentGO:0048747520.013
protein homooligomerizationGO:005126030.013
nephron tubule morphogenesisGO:007207810.013
phagocytosis engulfmentGO:000691110.013
regulation of cell activationGO:005086510.013
positive regulation of notch signaling pathwayGO:004574730.013
gland developmentGO:00487321430.013
positive regulation of biological processGO:00485182530.013
regulation of neural precursor cell proliferationGO:200017730.013
regulation of protein transportGO:005122330.013
somatic muscle developmentGO:000752540.013
cellular amino acid metabolic processGO:000652070.013
cellular response to radiationGO:007147840.013
modification dependent macromolecule catabolic processGO:004363230.013
protein complex disassemblyGO:004324110.013
regulation of dendrite morphogenesisGO:004881430.013
developmental growthGO:00485891660.012
regulation of cellular carbohydrate metabolic processGO:001067540.012
cognitionGO:005089010.012
response to uvGO:000941130.012
nuclear migrationGO:000709730.012
positive regulation of immune effector processGO:000269930.012
neuron projection developmentGO:00311751800.012
meiotic nuclear divisionGO:000712640.012
protein heterooligomerizationGO:005129110.012
forebrain regionalizationGO:002187140.012
positive regulation of cellular amine metabolic processGO:003324000.012
positive regulation of nitrogen compound metabolic processGO:0051173690.012
female sex differentiationGO:004666040.012
regulation of circadian rhythmGO:004275240.012
cell migrationGO:00164772370.012
circulatory system processGO:0003013870.012
response to glucoseGO:000974930.012
release of sequestered calcium ion into cytosolGO:005120930.012
ubiquitin dependent protein catabolic processGO:000651130.012
negative chemotaxisGO:005091910.012
connective tissue developmentGO:0061448990.012
growthGO:00400071740.012
single organism organelle organizationGO:19025891990.012
regulation of i kappab kinase nf kappab signalingGO:004312240.012
axonogenesisGO:00074091520.012
negative regulation of stem cell differentiationGO:200073720.012
posterior lateral line neuromast primordium migrationGO:0048920120.012
positive regulation of myeloid cell differentiationGO:004563920.012
adipose tissue developmentGO:006061210.012
mesenchyme developmentGO:00604851270.012
production of molecular mediator of immune responseGO:000244020.012
cell cycle g1 s phase transitionGO:004484310.012
positive regulation of nucleotide catabolic processGO:003081310.012
nuclear importGO:005117030.012
somitogenesisGO:0001756870.012
regulation of transcription dna templatedGO:00063552130.012
b cell activationGO:004211320.012
glucose homeostasisGO:004259310.012
positive regulation of peptidyl tyrosine phosphorylationGO:005073110.012
blood circulationGO:0008015870.012
proteasome mediated ubiquitin dependent protein catabolic processGO:004316120.012
cell cycle arrestGO:000705010.012
organism emergence from protective structureGO:007168440.012
negative regulation of protein kinase activityGO:000646940.012
activation of mapk activityGO:000018730.012
regulation of membrane potentialGO:0042391230.012
negative regulation of cytokine productionGO:000181810.012
embryo development ending in birth or egg hatchingGO:00097922710.011
striated muscle cell differentiationGO:00511461290.011
golgi vesicle transportGO:004819330.011
germ line stem cell maintenanceGO:003071820.011
homeostatic processGO:00425921420.011
g protein coupled receptor signaling pathwayGO:0007186740.011
positive regulation of dna metabolic processGO:005105410.011
regulation of anatomical structure morphogenesisGO:00226031300.011
regulation of calcium ion transportGO:005192420.011
oxoacid metabolic processGO:0043436310.011
regulation of organ growthGO:004662030.011
forebrain developmentGO:0030900960.011
erk1 and erk2 cascadeGO:007037140.011
branching morphogenesis of a nerveGO:004875540.011
response to organic substanceGO:00100331530.011
protein stabilizationGO:005082120.011
regulation of inflammatory responseGO:005072720.011
response to alkaloidGO:004327920.011
negative regulation of developmental processGO:0051093650.011
lymphocyte proliferationGO:004665110.011
regulation of cell differentiationGO:00455951420.011
alcohol biosynthetic processGO:004616520.011
sprouting angiogenesisGO:0002040530.011
regulation of cell substrate adhesionGO:001081010.011
neuromuscular synaptic transmissionGO:000727420.011
endocrine processGO:005088620.011
establishment of synaptic vesicle localizationGO:009748010.011
meiotic cell cycle processGO:190304630.011
mitochondrion organizationGO:000700540.011
transportGO:00068102200.011
endosomal transportGO:001619720.011
skeletal system morphogenesisGO:00487051020.011
positive regulation of epithelial cell proliferationGO:005067910.011
heart developmentGO:00075073130.011
atp catabolic processGO:000620040.011
phosphate containing compound metabolic processGO:00067961080.011
wnt signaling pathwayGO:0016055800.011
single organism localizationGO:19025782250.011
regulation of protein complex disassemblyGO:004324410.011
glucose importGO:004632320.011
melanin metabolic processGO:000658220.011
negative regulation of reproductive processGO:200024230.011
negative regulation of synapse assemblyGO:005196420.011
positive regulation of gtpase activityGO:004354710.011
nephron morphogenesisGO:007202820.011
small molecule catabolic processGO:004428230.010
calcium ion transport into cytosolGO:006040230.010
actin mediated cell contractionGO:007025210.010
exocytosisGO:000688710.010
establishment of endothelial barrierGO:006102830.010
mesenchymal cell proliferationGO:001046310.010
regulation of neurotransmitter transportGO:005158810.010
regulation of intracellular protein transportGO:003315730.010
muscle structure developmentGO:00610611960.010
regulation of sequestering of calcium ionGO:005128240.010
forebrain cell migrationGO:002188510.010
cytosolic calcium ion transportGO:006040130.010
regulation of carbohydrate biosynthetic processGO:004325510.010
rna localizationGO:000640340.010
transcription from rna polymerase ii promoterGO:0006366800.010
pancreas developmentGO:0031016840.010
protein depolymerizationGO:005126110.010
positive regulation of multi organism processGO:004390230.010
energy reserve metabolic processGO:000611220.010
post embryonic organ developmentGO:004856940.010
regulation of ion transmembrane transporter activityGO:003241220.010
regulation of cell shapeGO:000836010.010
regulation of nucleocytoplasmic transportGO:004682220.010
regulation of systemic arterial blood pressureGO:000307310.010
extrinsic apoptotic signaling pathway in absence of ligandGO:009719210.010
positive regulation of epithelial cell migrationGO:001063420.010
regulation of dendrite developmentGO:005077330.010

lrp6 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
musculoskeletal system diseaseDOID:1700.043
disease of anatomical entityDOID:700.043
eye and adnexa diseaseDOID:149200.030
nervous system diseaseDOID:86300.030
eye diseaseDOID:561400.030
sensory system diseaseDOID:005015500.030
connective tissue diseaseDOID:6500.017
bone diseaseDOID:008000100.016
organ system cancerDOID:005068600.013
disease of cellular proliferationDOID:1456600.013
cancerDOID:16200.013
disease of metabolismDOID:001466700.013
retinal diseaseDOID:567900.012