Danio rerio

60 known processes

rspo3

R-spondin 3 homolog (Xenopus laevis)

(Aliases: wu:fa13e08,thsd2,D32,sb:cb387,cb387,MGC162040,zgc:162040)

rspo3 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
smoothened signaling pathwayGO:0007224300.803
localization of cellGO:00516742440.758
positive regulation of cell cycleGO:004578730.722
gastrulationGO:00073692080.672
tube morphogenesisGO:00352393490.652
cell surface receptor signaling pathwayGO:00071663250.644
blood vessel morphogenesisGO:00485142160.616
Zebrafish
morphogenesis of an epitheliumGO:00020093330.602
Mouse
mesenchymal cell developmentGO:0014031780.577
regulation of nitrogen compound metabolic processGO:00511712510.563
determination of left right symmetryGO:00073681790.456
cell migrationGO:00164772370.433
embryonic organ developmentGO:00485683810.420
Mouse
chordate embryonic developmentGO:00430092710.408
Mouse
regulation of cell differentiationGO:00455951420.400
cell proliferationGO:0008283800.396
mesenchyme developmentGO:00604851270.388
regulation of organ growthGO:004662030.383
cell motilityGO:00488702440.362
heart developmentGO:00075073130.347
epithelial tube morphogenesisGO:00605621480.334
positive regulation of cellular processGO:00485222010.332
determination of bilateral symmetryGO:00098552040.331
embryonic organ morphogenesisGO:00485622740.316
negative regulation of gliogenesisGO:001401410.309
cellular component movementGO:00069283350.308
digestive system developmentGO:00551232890.304
cellular response to stressGO:0033554620.301
determination of heart left right asymmetryGO:00613711170.299
lymphocyte differentiationGO:003009890.293
convergent extensionGO:00600261180.291
canonical wnt signaling pathwayGO:0060070480.288
digestive tract morphogenesisGO:00485462310.286
stem cell differentiationGO:00488631170.281
blood vessel developmentGO:00015682460.280
Zebrafish
sensory organ developmentGO:00074233930.277
embryonic cranial skeleton morphogenesisGO:0048701900.276
regulation of glial cell differentiationGO:004568540.275
immune system processGO:00023762410.264
organic substance biosynthetic processGO:19015762890.263
negative regulation of cellular processGO:00485232830.253
rna biosynthetic processGO:00327741810.232
regulation of smoothened signaling pathwayGO:0008589180.220
hemopoiesisGO:00300971830.220
heart morphogenesisGO:00030071560.219
programmed cell deathGO:00125011190.216
heart loopingGO:0001947940.206
positive regulation of map kinase activityGO:004340630.205
sensory organ morphogenesisGO:00905962000.201
vasculature developmentGO:00019442780.195
Zebrafish
sequestering of metal ionGO:005123830.193
immune system developmentGO:00025201910.170
establishment of localization in cellGO:0051649770.166
pancreas developmentGO:0031016840.164
positive regulation of biological processGO:00485182530.163
digestive tract developmentGO:00485652650.152
myotome developmentGO:006105510.143
locomotionGO:00400113130.139
nucleobase containing compound biosynthetic processGO:00346542050.139
single organism carbohydrate metabolic processGO:0044723120.136
regulation of rna metabolic processGO:00512522240.135
embryonic neurocranium morphogenesisGO:0048702150.133
apoptotic processGO:00069151160.132
astrocyte differentiationGO:004870810.130
regulation of protein modification by small protein conjugation or removalGO:190332030.129
transmembrane receptor protein serine threonine kinase signaling pathwayGO:0007178680.128
activation of mapk activityGO:000018730.125
positive regulation of macromolecule metabolic processGO:0010604930.125
gall bladder developmentGO:006101010.124
regulation of transcription dna templatedGO:00063552130.117
anterior head developmentGO:009706520.117
specification of symmetryGO:00097992040.116
regulation of establishment of planar polarityGO:009017540.114
b cell activationGO:004211320.113
cardioblast migration to the midline involved in heart field formationGO:006097570.112
embryonic heart tube developmentGO:00350501330.109
oligodendrocyte differentiationGO:0048709230.104
gliogenesisGO:0042063450.099
hepatic duct developmentGO:006101120.099
skeletal system developmentGO:00015011810.098
regulation of gene expressionGO:00104682650.098
organic cyclic compound biosynthetic processGO:19013622230.098
lymphocyte activationGO:0046649100.097
gene expressionGO:00104672520.095
regulation of biosynthetic processGO:00098892500.093
regulation of signalingGO:00230512350.092
positive regulation of canonical wnt signaling pathwayGO:009026340.089
regulation of cellular response to growth factor stimulusGO:0090287350.089
neural crest cell differentiationGO:0014033720.088
central nervous system neuron differentiationGO:0021953740.088
negative regulation of cell differentiationGO:0045596460.088
regulation of cellular macromolecule biosynthetic processGO:20001122220.087
cell cycle g1 s phase transitionGO:004484310.087
regulation of cell developmentGO:00602841000.086
positive regulation of jnk cascadeGO:004633030.086
skeletal system morphogenesisGO:00487051020.085
b cell differentiationGO:003018310.085
regulation of cellular metabolic processGO:00313233200.084
negative regulation of developmental processGO:0051093650.084
regulation of jun kinase activityGO:004350630.083
negative regulation of biological processGO:00485193040.083
eye field cell fate commitment involved in camera type eye formationGO:006089830.082
positive regulation of apoptotic signaling pathwayGO:200123510.082
cytosolic calcium ion transportGO:006040130.082
neuron differentiationGO:00301823530.081
regulation of cell communicationGO:00106462320.080
regulation of glucose importGO:004632410.078
positive regulation of striated muscle cell differentiationGO:005115510.077
regulation of signal transductionGO:00099662250.077
central nervous system myelinationGO:002201020.076
regulation of anatomical structure morphogenesisGO:00226031300.076
regulation of transcription from rna polymerase ii promoterGO:00063571140.076
regulation of gastrulationGO:0010470240.075
striated muscle cell differentiationGO:00511461290.075
nitrogen compound metabolic processGO:00068073190.074
leukocyte differentiationGO:0002521250.074
neuron developmentGO:00486662620.073
regulation of canonical wnt signaling pathwayGO:0060828340.073
negative regulation of anterior neural cell fate commitment of the neural plateGO:002200110.072
positive regulation of cell deathGO:0010942290.070
regulation of developmental processGO:00507932470.069
hepatocyte proliferationGO:007257420.068
cardioblast migrationGO:000326070.067
axon ensheathment in central nervous systemGO:003229120.067
regulation of wnt signaling pathway involved in digestive tract morphogenesisGO:200005620.066
regulation of organ morphogenesisGO:2000027350.066
wnt signaling pathway planar cell polarity pathwayGO:006007140.066
regulation of neurogenesisGO:0050767870.065
stem cell maintenanceGO:001982740.065
regulation of transmembrane receptor protein serine threonine kinase signaling pathwayGO:0090092500.064
negative regulation of mesodermal cell fate specificationGO:004266230.064
t cell differentiation in thymusGO:003307760.064
regulation of multicellular organism growthGO:004001440.064
negative regulation of anterior neural cell fate commitment of the neural plate by wnt signaling pathwayGO:002200210.063
neural crest cell migrationGO:0001755420.063
leukocyte proliferationGO:007066110.063
negative regulation of signal transductionGO:0009968940.062
inner ear developmentGO:00488391260.061
eye developmentGO:00016542770.060
positive regulation of rna metabolic processGO:0051254590.059
dorsal ventral pattern formationGO:00099531250.059
optic placode formation involved in camera type eye formationGO:004661930.059
regulation of multicellular organismal processGO:00512392770.058
regulation of oligodendrocyte differentiationGO:004871310.057
positive regulation of stress activated mapk cascadeGO:003287430.057
wnt signaling pathwayGO:0016055800.056
embryonic heart tube morphogenesisGO:00031431080.055
negative regulation of cell communicationGO:0010648960.055
enzyme linked receptor protein signaling pathwayGO:00071671060.054
Zebrafish
negative regulation of nucleobase containing compound metabolic processGO:0045934590.053
epithelial cell proliferation involved in liver morphogenesisGO:007257520.052
growthGO:00400071740.052
nuclear importGO:005117030.052
positive regulation of stress activated protein kinase signaling cascadeGO:007030430.051
axon guidanceGO:0007411860.051
deathGO:00162651210.051
regulation of multicellular organismal developmentGO:20000262230.050
mesenchymal cell proliferationGO:001046310.050
stem cell developmentGO:0048864820.049
mitotic cytokinesisGO:000028130.049
heart formationGO:0060914130.047
single organism nuclear importGO:190259330.046
glycoprotein metabolic processGO:0009100230.045
organic acid metabolic processGO:0006082310.045
positive regulation of developmental processGO:0051094500.045
metal ion transportGO:0030001580.045
optic placode formationGO:000174340.044
muscle cell differentiationGO:00426921390.044
aromatic compound biosynthetic processGO:00194382170.044
positive regulation of sequence specific dna binding transcription factor activityGO:005109170.044
positive regulation of cellular protein metabolic processGO:0032270220.043
myeloid cell differentiationGO:0030099860.042
cell divisionGO:0051301200.042
developmental growthGO:00485891660.042
endocrine pancreas developmentGO:0031018270.042
response to drugGO:004249330.041
spinal cord patterningGO:002151160.041
behaviorGO:0007610740.041
endodermal cell fate determinationGO:000749320.041
ameboidal type cell migrationGO:00016671430.041
central nervous system developmentGO:00074173870.041
negative regulation of response to stimulusGO:00485851040.041
cellular amino acid metabolic processGO:000652070.040
hematopoietic or lymphoid organ developmentGO:00485341910.039
embryonic skeletal system morphogenesisGO:0048704930.039
peptide transportGO:001583310.039
regulation of histone methylationGO:003106030.038
positive regulation of cell divisionGO:005178120.038
detection of stimulusGO:0051606290.038
neural tube developmentGO:0021915620.037
regulation of cell cycle processGO:0010564200.037
neural crest cell developmentGO:0014032620.036
positive regulation of neuron migrationGO:200122420.036
spinal cord developmentGO:0021510460.036
fourth ventricle developmentGO:002159280.035
columnar cuboidal epithelial cell differentiationGO:0002065380.035
negative regulation of cellular component movementGO:0051271180.034
striated muscle cell developmentGO:00550021080.034
t cell activationGO:004211060.034
angiogenesisGO:00015251580.034
Zebrafish
carboxylic acid metabolic processGO:0019752220.034
positive regulation of muscle tissue developmentGO:190186310.033
ear developmentGO:00435831270.033
regulation of apoptotic processGO:0042981980.033
cytokinesisGO:000091030.033
retina development in camera type eyeGO:00600411460.033
regulation of chromosome segregationGO:005198310.033
regulation of wnt signaling pathwayGO:0030111530.033
otic placode formationGO:0043049230.033
regulation of intracellular protein transportGO:003315730.032
regulation of nucleic acid templated transcriptionGO:19035062130.032
pectoral fin morphogenesisGO:0035138290.032
cellular nitrogen compound biosynthetic processGO:00442712180.032
nucleic acid metabolic processGO:00903042440.032
cellular response to chemical stimulusGO:00708871570.032
g1 s transition of mitotic cell cycleGO:000008210.031
nucleic acid templated transcriptionGO:00976591810.031
kidney developmentGO:0001822920.031
mitotic cell cycleGO:0000278640.031
symbiosis encompassing mutualism through parasitismGO:004440340.031
stem cell divisionGO:001714510.031
somatic stem cell maintenanceGO:003501910.031
cell fate commitmentGO:0045165990.031
multicellular organism growthGO:003526440.031
ventral midline developmentGO:0007418130.030
regulation of rna biosynthetic processGO:20011412130.030
response to bacteriumGO:0009617580.030
cell activationGO:0001775160.030
neuron projection extensionGO:1990138450.029
neuron remodelingGO:001632210.029
regulation of fibroblast growth factor receptor signaling pathwayGO:0040036200.029
macromolecule biosynthetic processGO:00090592270.028
cellular macromolecule metabolic processGO:00442603910.028
signal transductionGO:00071654550.028
proximal distal pattern formationGO:000995410.027
neuronal action potentialGO:0019228180.027
regulation of macromolecule biosynthetic processGO:00105562250.027
cytoskeleton dependent cytokinesisGO:006164030.027
nucleobase containing compound metabolic processGO:00061392740.026
aorta developmentGO:003590440.026
nucleocytoplasmic transportGO:000691340.026
striated muscle tissue developmentGO:00147061100.025
regulation of epithelial cell proliferationGO:005067830.025
macromolecular complex subunit organizationGO:0043933740.025
single organism transportGO:00447652060.025
eye morphogenesisGO:00485921440.025
cell differentiation in spinal cordGO:0021515400.025
liver developmentGO:0001889960.025
negative regulation of cell developmentGO:0010721260.025
mitotic cell cycle processGO:1903047480.024
transcription from rna polymerase ii promoterGO:0006366800.024
regulation of cellular amine metabolic processGO:003323800.024
cellular protein catabolic processGO:004425740.024
glial cell differentiationGO:0010001420.024
wnt signaling pathway involved in digestive tract morphogenesisGO:004433340.024
phosphorus metabolic processGO:00067931090.024
urogenital system developmentGO:0001655970.024
pronephros developmentGO:0048793690.023
regulation of wound healingGO:006104120.023
positive regulation of catabolic processGO:000989640.023
regulation of extrinsic apoptotic signaling pathwayGO:200123630.023
non canonical wnt signaling pathwayGO:0035567130.023
transcription dna templatedGO:00063511810.023
olfactory placode morphogenesisGO:007169970.023
positive regulation of cell communicationGO:0010647560.023
negative chemotaxisGO:005091910.023
muscle structure developmentGO:00610611960.023
negative regulation of cell proliferationGO:000828580.023
regulation of cell deathGO:00109411030.023
negative regulation of cytoplasmic transportGO:190365020.022
forebrain neuron fate commitmentGO:002187710.022
positive regulation of chromosome segregationGO:005198410.022
l amino acid transportGO:001580710.022
renal system developmentGO:0072001940.022
positive regulation of translationGO:004572710.022
embryonic camera type eye formationGO:0060900100.022
endodermal digestive tract morphogenesisGO:006103120.021
negative regulation of macromolecule metabolic processGO:0010605760.021
developmental pigmentationGO:0048066480.021
regulation of programmed cell deathGO:00430671010.021
regulation of nucleobase containing compound metabolic processGO:00192192500.021
fibroblast growth factor receptor signaling pathwayGO:0008543220.021
camera type eye developmentGO:00430102220.020
positive regulation of signalingGO:0023056560.020
positive regulation of muscle cell differentiationGO:005114910.020
regulation of response to stimulusGO:00485832690.020
cellular response to fibroblast growth factor stimulusGO:0044344220.020
regulation of anterior head developmentGO:200074220.020
cell projection organizationGO:00300302840.020
regulation of cellular biosynthetic processGO:00313262450.020
organic acid biosynthetic processGO:0016053120.020
cell morphogenesisGO:00009022890.019
ventricular cardiac muscle tissue morphogenesisGO:005501020.019
odontogenesis of dentin containing toothGO:004247510.019
regenerationGO:0031099910.019
schwann cell developmentGO:001404490.019
cell migration involved in heart developmentGO:0060973220.019
axis elongationGO:0003401310.019
cellular biosynthetic processGO:00442492860.019
cellular protein metabolic processGO:00442671290.019
cellular localizationGO:0051641970.019
positive regulation of smoothened signaling pathwayGO:004588050.019
muscle tissue developmentGO:00605371100.019
regulation of mrna catabolic processGO:006101330.018
negative regulation of jnk cascadeGO:004632910.018
positive regulation of fibroblast growth factor receptor signaling pathwayGO:004574390.018
lateral inhibitionGO:004633110.018
mesenchymal cell differentiationGO:0048762870.018
positive regulation of gene expressionGO:0010628710.018
negative regulation of signal transduction in absence of ligandGO:190109910.018
regulation of heart morphogenesisGO:2000826170.018
regulation of cell divisionGO:0051302120.018
gtp catabolic processGO:000618420.018
extrinsic apoptotic signaling pathwayGO:009719130.018
sequestering of calcium ionGO:005120830.017
amine metabolic processGO:000930820.017
regulation of cell agingGO:009034210.017
protein importGO:001703830.017
protein import into nucleusGO:000660630.017
protein secretionGO:000930610.017
positive regulation of transportGO:005105020.017
aorta morphogenesisGO:003590930.017
regulation of cellular protein metabolic processGO:0032268520.016
regulation of localizationGO:00328791040.016
developmental maturationGO:0021700340.016
regulation of nucleocytoplasmic transportGO:004682220.016
regulation of protein targetingGO:190353320.016
cellular carbohydrate metabolic processGO:004426240.016
protein modification processGO:00362111000.016
cerebellar granular layer formationGO:002168430.016
defense responseGO:0006952470.016
negative regulation of epithelial cell proliferationGO:005068010.016
regulation of carbohydrate metabolic processGO:000610940.016
neuroblast proliferationGO:000740520.016
positive regulation of nucleic acid templated transcriptionGO:1903508570.016
regulation of developmental pigmentationGO:004807060.016
meiosis iGO:000712710.016
embryonic eye morphogenesisGO:0048048300.016
regulation of endothelial cell proliferationGO:000193610.016
tissue regenerationGO:0042246740.016
cellular response to hypoxiaGO:007145610.016
regulation of developmental growthGO:0048638380.016
nephron morphogenesisGO:007202820.015
positive regulation of glial cell differentiationGO:004568710.015
erk1 and erk2 cascadeGO:007037140.015
primary neural tube formationGO:001402010.015
embryonic skeletal system developmentGO:0048706970.015
cell deathGO:00082191210.015
otic vesicle morphogenesisGO:0071600340.015
foregut morphogenesisGO:000744040.015
single organism metabolic processGO:00447102170.015
thrombocyte differentiationGO:000257440.015
modification dependent macromolecule catabolic processGO:004363230.015
negative regulation of cellular biosynthetic processGO:0031327550.015
actin filament based processGO:0030029640.015
regulation of locomotionGO:0040012550.015
cell maturationGO:0048469230.014
cellular response to oxygen levelsGO:007145310.014
single organism organelle organizationGO:19025891990.014
endocardium morphogenesisGO:000316040.014
regulation of growthGO:0040008420.014
developmental programmed cell deathGO:001062340.014
synaptic vesicle localizationGO:009747910.014
cell fate commitment involved in pattern specificationGO:006058160.014
cellular aromatic compound metabolic processGO:00067252950.014
regulation of cell activationGO:005086510.014
myotube differentiationGO:0014902450.014
negative regulation of axon extension involved in axon guidanceGO:004884310.014
response to chemicalGO:00422213200.014
positive regulation of striated muscle tissue developmentGO:004584410.014
positive regulation of muscle organ developmentGO:004863610.014
organelle organizationGO:00069962270.014
response to organic substanceGO:00100331530.014
neuromuscular process controlling balanceGO:005088530.014
regulation of protein import into nucleusGO:004230620.014
neuroepithelial cell differentiationGO:0060563260.014
mapk cascadeGO:0000165180.013
positive regulation of immune effector processGO:000269930.013
positive regulation of cellular amine metabolic processGO:003324000.013
hepaticobiliary system developmentGO:0061008980.013
regulation of cell matrix adhesionGO:000195210.013
positive regulation of cellular catabolic processGO:003133130.013
regulation of muscle tissue developmentGO:190186160.013
protein complex localizationGO:003150310.013
regulation of cell cycleGO:0051726520.013
establishment of protein localization to organelleGO:007259440.013
regulation of embryonic developmentGO:0045995470.013
cytoplasmic transportGO:0016482110.013
convergent extension involved in organogenesisGO:0060029100.013
cellular nitrogen compound metabolic processGO:00346412900.013
i kappab kinase nf kappab signalingGO:000724940.013
rna 3 end processingGO:003112320.013
neural tube patterningGO:0021532330.013
autophagyGO:000691440.013
multicellular organismal signalingGO:0035637220.013
pancreatic a cell differentiationGO:000331060.013
negative regulation of fibroblast growth factor receptor signaling pathwayGO:004003760.012
regulation of protein ubiquitinationGO:003139630.012
regulation of cellular ketone metabolic processGO:001056570.012
actin polymerization or depolymerizationGO:000815420.012
head developmentGO:00603223030.012
positive regulation of programmed cell deathGO:0043068290.012
cell matrix adhesionGO:000716040.012
positive regulation of apoptotic processGO:0043065290.012
negative regulation of metabolic processGO:0009892860.012
regulation of catalytic activityGO:0050790550.012
type b pancreatic cell developmentGO:000332340.012
regulation of biological qualityGO:00650082630.012
regulation of cytoplasmic transportGO:190364940.012
response to endoplasmic reticulum stressGO:003497660.012
pancreatic a cell developmentGO:000332220.012
regulation of metabolic processGO:00192223590.012
regulation of endodermal cell fate specificationGO:0042663150.012
response to oxidative stressGO:0006979110.012
regulation of protein transportGO:005122330.012
retinoic acid biosynthetic processGO:000213860.012
regulation of cartilage developmentGO:006103570.012
neuron migrationGO:0001764220.012
multicellular organismal response to stressGO:003355520.012
regulation of cellular amino acid metabolic processGO:000652100.012
proteasome mediated ubiquitin dependent protein catabolic processGO:004316120.012
regulation of meiotic cell cycleGO:005144510.012
regulation of blood coagulationGO:003019310.011
cell part morphogenesisGO:00329902460.011
stem cell proliferationGO:007208940.011
positive regulation of production of molecular mediator of immune responseGO:000270210.011
regulation of mrna processingGO:005068430.011
regulation of wnt signaling pathway calcium modulating pathwayGO:000859130.011
epithelial cell developmentGO:0002064420.011
notochord developmentGO:0030903540.011
positive regulation of cell fate commitmentGO:001045510.011
extrinsic apoptotic signaling pathway in absence of ligandGO:009719210.011
negative regulation of intracellular transportGO:003238730.011
negative regulation of transcription dna templatedGO:0045892450.011
interspecies interaction between organismsGO:004441940.011
regulation of gliogenesisGO:001401360.011
negative regulation of multicellular organismal processGO:0051241690.011
negative regulation of map kinase activityGO:004340720.011
regulation of mesenchymal cell proliferationGO:001046410.011
neural retina developmentGO:0003407490.011
floor plate formationGO:0021508120.011
production of molecular mediator of immune responseGO:000244020.010
monocarboxylic acid biosynthetic processGO:0072330120.010
positive regulation of secretion by cellGO:190353210.010
divalent inorganic cation transportGO:0072511210.010
mitotic dna integrity checkpointGO:004477440.010
cell cycleGO:0007049930.010
wnt signaling pathway involved in dorsal ventral axis specificationGO:004433250.010
dna alkylationGO:000630580.010
regulation of cell proliferationGO:0042127370.010
regulation of stem cell proliferationGO:007209120.010
establishment of localizationGO:00512342440.010
regulation of dendrite morphogenesisGO:004881430.010
oocyte maturationGO:000155640.010
pigment cell differentiationGO:0050931380.010

rspo3 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
nervous system diseaseDOID:86300.192
disease of anatomical entityDOID:700.192
eye and adnexa diseaseDOID:149200.074
eye diseaseDOID:561400.074
sensory system diseaseDOID:005015500.074
retinal diseaseDOID:567900.074
organ system cancerDOID:005068600.023
cancerDOID:16200.023
disease of cellular proliferationDOID:1456600.023
gastrointestinal system cancerDOID:311900.012