IMP: Integrative Multi-species Prediction

Danio rerio

7 known processes

pax9

paired box gene 9

ZFIN: ZDB-GENE-980526-399
Entrez: 30558
Ensembl: ENSDARG00000053829
UniProtKB: Q98866
UniProtKB: Q98865

Process Predictions
Disease Predictions

pax9 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
inner ear development	GO:0048839	126	0.868	Zebrafish
larval development	GO:0002164	2	0.839
embryonic skeletal system morphogenesis	GO:0048704	93	0.782
chordate embryonic development	GO:0043009	271	0.779	Zebrafish
positive regulation of rna metabolic process	GO:0051254	59	0.749	Mouse
sensory organ morphogenesis	GO:0090596	200	0.727	Zebrafish
cellular biosynthetic process	GO:0044249	286	0.723	Human Mouse
connective tissue development	GO:0061448	99	0.717
cellular macromolecule biosynthetic process	GO:0034645	224	0.707	Human Mouse
macromolecule biosynthetic process	GO:0009059	227	0.675	Human Mouse
positive regulation of cellular process	GO:0048522	201	0.675	Mouse
transcription dna templated	GO:0006351	181	0.644	Human Mouse
embryonic organ development	GO:0048568	381	0.640	Zebrafish
cartilage development	GO:0051216	96	0.606
embryonic organ morphogenesis	GO:0048562	274	0.588	Zebrafish
positive regulation of biological process	GO:0048518	253	0.526	Mouse
embryonic limb morphogenesis	GO:0030326	2	0.520
embryonic cranial skeleton morphogenesis	GO:0048701	90	0.503
appendage development	GO:0048736	80	0.502
embryonic skeletal system development	GO:0048706	97	0.487
otic vesicle morphogenesis	GO:0071600	34	0.482	Zebrafish
skeletal system development	GO:0001501	181	0.478
aromatic compound biosynthetic process	GO:0019438	217	0.460	Human Mouse
cell proliferation	GO:0008283	80	0.459
stem cell differentiation	GO:0048863	117	0.443
regulation of chondrocyte differentiation	GO:0032330	1	0.437
inner ear morphogenesis	GO:0042472	63	0.435	Zebrafish
central nervous system development	GO:0007417	387	0.430	Zebrafish
taxis	GO:0042330	109	0.421
eye development	GO:0001654	277	0.407	Zebrafish
mesoderm development	GO:0007498	88	0.394
nucleobase containing compound metabolic process	GO:0006139	274	0.392	Human Mouse
neural crest cell differentiation	GO:0014033	72	0.391
axonogenesis	GO:0007409	152	0.387
appendage morphogenesis	GO:0035107	56	0.385
positive regulation of nucleic acid templated transcription	GO:1903508	57	0.383	Mouse
biosynthetic process	GO:0009058	294	0.373	Human Mouse
embryo development ending in birth or egg hatching	GO:0009792	271	0.353	Zebrafish
organic substance biosynthetic process	GO:1901576	289	0.351	Human Mouse
stem cell development	GO:0048864	82	0.350
organic cyclic compound metabolic process	GO:1901360	301	0.349	Human Mouse
eye morphogenesis	GO:0048592	144	0.349	Zebrafish
cell morphogenesis involved in differentiation	GO:0000904	195	0.346
skeletal system morphogenesis	GO:0048705	102	0.334
nucleobase containing compound biosynthetic process	GO:0034654	205	0.323	Human Mouse
regulation of cellular metabolic process	GO:0031323	320	0.315	Human Mouse
sympathetic nervous system development	GO:0048485	3	0.312
ear morphogenesis	GO:0042471	64	0.305	Zebrafish
muscle cell differentiation	GO:0042692	139	0.299
mesenchymal cell differentiation	GO:0048762	87	0.299
positive regulation of cellular biosynthetic process	GO:0031328	68	0.289	Mouse
regulation of rna metabolic process	GO:0051252	224	0.285	Human Mouse
regulation of nucleobase containing compound metabolic process	GO:0019219	250	0.285	Human Mouse
response to chemical	GO:0042221	320	0.280	Mouse
regulation of cellular macromolecule biosynthetic process	GO:2000112	222	0.278	Human Mouse
morphogenesis of an epithelium	GO:0002009	333	0.273	Zebrafish
nitrogen compound metabolic process	GO:0006807	319	0.273	Human Mouse
bmp signaling pathway involved in heart development	GO:0061312	15	0.268
cranial suture morphogenesis	GO:0060363	1	0.267
craniofacial suture morphogenesis	GO:0097094	2	0.265
cellular nitrogen compound metabolic process	GO:0034641	290	0.262	Human Mouse
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	68	0.256
sensory organ development	GO:0007423	393	0.254	Zebrafish
camera type eye morphogenesis	GO:0048593	108	0.253	Zebrafish
tissue remodeling	GO:0048771	4	0.249
muscle structure development	GO:0061061	196	0.249
cell surface receptor signaling pathway	GO:0007166	325	0.248
regulation of cellular biosynthetic process	GO:0031326	245	0.248	Human Mouse
cellular nitrogen compound biosynthetic process	GO:0044271	218	0.246	Human Mouse
single organism localization	GO:1902578	225	0.243
gene expression	GO:0010467	252	0.240	Human Mouse
regulation of multicellular organismal process	GO:0051239	277	0.238	Mouse
heart jogging	GO:0003146	40	0.237
hair cell differentiation	GO:0035315	32	0.235	Zebrafish
semicircular canal development	GO:0060872	24	0.234
neural crest cell development	GO:0014032	62	0.232
nucleic acid templated transcription	GO:0097659	181	0.232	Human Mouse
ear development	GO:0043583	127	0.230	Zebrafish
regulation of autophagy	GO:0010506	3	0.229
regulation of rna biosynthetic process	GO:2001141	213	0.229	Human Mouse
regulation of biosynthetic process	GO:0009889	250	0.226	Human Mouse
vasculature development	GO:0001944	278	0.225
epithelial to mesenchymal transition	GO:0001837	21	0.217
semicircular canal morphogenesis	GO:0048752	18	0.216
camera type eye development	GO:0043010	222	0.216	Zebrafish
mesenchymal cell development	GO:0014031	78	0.212
cell morphogenesis	GO:0000902	289	0.204
skeletal muscle tissue development	GO:0007519	67	0.201
neuron differentiation	GO:0030182	353	0.198	Zebrafish
cell projection morphogenesis	GO:0048858	244	0.197
response to oxygen containing compound	GO:1901700	55	0.194
regulation of nitrogen compound metabolic process	GO:0051171	251	0.193	Human Mouse
negative regulation of biological process	GO:0048519	304	0.192	Human
transport	GO:0006810	220	0.189
embryonic viscerocranium morphogenesis	GO:0048703	52	0.187
stem cell proliferation	GO:0072089	4	0.181
embryonic camera type eye development	GO:0031076	29	0.181	Zebrafish
generation of neurons	GO:0048699	385	0.178	Zebrafish
response to abiotic stimulus	GO:0009628	122	0.175
regulation of metal ion transport	GO:0010959	4	0.172
forebrain development	GO:0030900	96	0.172
muscle tissue development	GO:0060537	110	0.169
urogenital system development	GO:0001655	97	0.169	Zebrafish
regulation of macromolecule biosynthetic process	GO:0010556	225	0.168	Human Mouse
odontogenesis of dentin containing tooth	GO:0042475	1	0.166
immune system process	GO:0002376	241	0.164
blood vessel development	GO:0001568	246	0.162
cell motility	GO:0048870	244	0.159
regulation of transcription from rna polymerase ii promoter involved in determination of left right symmetry	GO:1900094	17	0.155
epithelial cell differentiation	GO:0030855	116	0.151	Zebrafish
bmp signaling pathway involved in heart jogging	GO:0003303	14	0.145
positive regulation of gene expression	GO:0010628	71	0.141	Mouse
locus ceruleus development	GO:0021703	3	0.136
localization of cell	GO:0051674	244	0.133
gliogenesis	GO:0042063	45	0.131
retina development in camera type eye	GO:0060041	146	0.127
positive regulation of transport	GO:0051050	2	0.127
blood circulation	GO:0008015	87	0.125
blood vessel morphogenesis	GO:0048514	216	0.123
regulation of cell communication	GO:0010646	232	0.123
enzyme linked receptor protein signaling pathway	GO:0007167	106	0.121
nucleic acid metabolic process	GO:0090304	244	0.120	Human Mouse
regulation of gene expression	GO:0010468	265	0.120	Human Mouse
head development	GO:0060322	303	0.119	Zebrafish Mouse
heterocycle biosynthetic process	GO:0018130	215	0.119	Human Mouse
type b pancreatic cell development	GO:0003323	4	0.118
mesenchyme development	GO:0060485	127	0.118
digestive system development	GO:0055123	289	0.116
neuron projection guidance	GO:0097485	86	0.116
renal system development	GO:0072001	94	0.115	Zebrafish
neuron projection morphogenesis	GO:0048812	161	0.115
retinal ganglion cell axon guidance	GO:0031290	35	0.115
ameboidal type cell migration	GO:0001667	143	0.112
positive regulation of transcription dna templated	GO:0045893	57	0.112	Mouse
positive regulation of rna biosynthetic process	GO:1902680	57	0.112	Mouse
positive regulation of biosynthetic process	GO:0009891	68	0.112	Mouse
rna biosynthetic process	GO:0032774	181	0.111	Human Mouse
digestive tract morphogenesis	GO:0048546	231	0.110
heterocycle metabolic process	GO:0046483	290	0.110	Human Mouse
angiogenesis	GO:0001525	158	0.110
pericardium morphogenesis	GO:0003344	1	0.109
positive regulation of cell cycle	GO:0045787	3	0.108
regulation of cell proliferation	GO:0042127	37	0.108
regulation of epithelial cell proliferation	GO:0050678	3	0.108
neural tube development	GO:0021915	62	0.107	Zebrafish
programmed cell death	GO:0012501	119	0.107
inner ear receptor cell differentiation	GO:0060113	29	0.107	Zebrafish
embryonic appendage morphogenesis	GO:0035113	30	0.107
mesenchymal cell proliferation	GO:0010463	1	0.104
organic cyclic compound biosynthetic process	GO:1901362	223	0.104	Human Mouse
rna metabolic process	GO:0016070	219	0.102	Human Mouse
response to organic substance	GO:0010033	153	0.101	Mouse
limb bud formation	GO:0060174	2	0.101
regulation of signaling	GO:0023051	235	0.101
specification of symmetry	GO:0009799	204	0.100
regulation of macromolecule metabolic process	GO:0060255	317	0.100	Human Mouse
mechanosensory lateral line system development	GO:0048881	49	0.096
cell migration	GO:0016477	237	0.095
striated muscle tissue development	GO:0014706	110	0.095
cell morphogenesis involved in neuron differentiation	GO:0048667	163	0.094
protein localization to nucleus	GO:0034504	3	0.094
nephron development	GO:0072006	31	0.093	Zebrafish
regulation of transcription dna templated	GO:0006355	213	0.092	Human Mouse
carboxylic acid catabolic process	GO:0046395	3	0.092
muscle fiber development	GO:0048747	52	0.091
axon guidance	GO:0007411	86	0.091
stem cell maintenance	GO:0019827	4	0.091
positive regulation of apoptotic signaling pathway	GO:2001235	1	0.089
regulation of nucleic acid templated transcription	GO:1903506	213	0.089	Human Mouse
kidney development	GO:0001822	92	0.089	Zebrafish
striated muscle cell differentiation	GO:0051146	129	0.088
muscle organ development	GO:0007517	101	0.087
signal transduction	GO:0007165	455	0.086
single organism biosynthetic process	GO:0044711	71	0.086
axon development	GO:0061564	166	0.083
embryonic eye morphogenesis	GO:0048048	30	0.082	Zebrafish
regulation of bmp signaling pathway involved in heart jogging	GO:2000223	12	0.081
i kappab kinase nf kappab signaling	GO:0007249	4	0.080
odontogenesis	GO:0042476	9	0.080	Mouse
hard palate development	GO:0060022	4	0.080
response to growth factor	GO:0070848	39	0.080	Mouse
cellular component morphogenesis	GO:0032989	336	0.079
anterior posterior pattern specification	GO:0009952	152	0.077	Zebrafish
regionalization	GO:0003002	274	0.076	Zebrafish
response to stress	GO:0006950	263	0.076
trigeminal nerve development	GO:0021559	3	0.076
positive regulation of nucleobase containing compound metabolic process	GO:0045935	69	0.076	Mouse
response to oxygen levels	GO:0070482	25	0.075
regulation of cell development	GO:0060284	100	0.075
embryonic digestive tract development	GO:0048566	4	0.073
limb development	GO:0060173	8	0.072
nuclear import	GO:0051170	3	0.072
pharyngeal muscle development	GO:0043282	4	0.071
regulation of primary metabolic process	GO:0080090	311	0.070	Human Mouse
regulation of stem cell differentiation	GO:2000736	4	0.068
peripheral nervous system development	GO:0007422	55	0.068	Zebrafish
monovalent inorganic cation transport	GO:0015672	42	0.067
autonomic nervous system development	GO:0048483	19	0.066
brain development	GO:0007420	293	0.065	Zebrafish
regulation of epithelial to mesenchymal transition	GO:0010717	3	0.064
single organism nuclear import	GO:1902593	3	0.064
extrinsic apoptotic signaling pathway	GO:0097191	3	0.064
positive regulation of macromolecule biosynthetic process	GO:0010557	59	0.064	Mouse
small molecule metabolic process	GO:0044281	77	0.064
circulatory system process	GO:0003013	87	0.064
cellular aromatic compound metabolic process	GO:0006725	295	0.063	Human Mouse
invagination involved in gastrulation with mouth forming second	GO:0055109	1	0.063
neuron projection development	GO:0031175	180	0.062
regulation of metabolic process	GO:0019222	359	0.062	Human Mouse
neural crest cell migration	GO:0001755	42	0.062
axon extension	GO:0048675	45	0.061
positive regulation of nitrogen compound metabolic process	GO:0051173	69	0.061	Mouse
tube morphogenesis	GO:0035239	349	0.061
regulation of transcription from rna polymerase ii promoter	GO:0006357	114	0.060	Mouse
neuron fate specification	GO:0048665	20	0.059
hemopoiesis	GO:0030097	183	0.059
locomotion	GO:0040011	313	0.059
transcription from rna polymerase ii promoter	GO:0006366	80	0.059	Mouse
positive regulation of macromolecule metabolic process	GO:0010604	93	0.059	Mouse
cartilage condensation	GO:0001502	3	0.058
otic placode formation	GO:0043049	23	0.058	Zebrafish
establishment of blood brain barrier	GO:0060856	2	0.058
cell death	GO:0008219	121	0.058
autophagy	GO:0006914	4	0.056
regulation of signal transduction	GO:0009966	225	0.056
positive regulation of epithelial cell proliferation	GO:0050679	1	0.056
developmental growth involved in morphogenesis	GO:0060560	86	0.056
positive regulation of neuron apoptotic process	GO:0043525	1	0.056
negative regulation of response to stimulus	GO:0048585	104	0.056
enteroendocrine cell differentiation	GO:0035883	9	0.055
rhombomere 5 development	GO:0021571	4	0.055
positive regulation of cell proliferation	GO:0008284	15	0.055
otolith development	GO:0048840	32	0.054
cellular macromolecule metabolic process	GO:0044260	391	0.054	Human Mouse
dorsal ventral pattern formation	GO:0009953	125	0.054
positive regulation of stem cell proliferation	GO:2000648	1	0.053
embryonic skeletal joint morphogenesis	GO:0060272	3	0.053
regulation of smoothened signaling pathway	GO:0008589	18	0.052
negative regulation of signaling	GO:0023057	96	0.051
epidermal cell differentiation	GO:0009913	36	0.051	Zebrafish
negative regulation of transcription dna templated	GO:0045892	45	0.051	Human
regulation of biomineral tissue development	GO:0070167	2	0.050
otic vesicle formation	GO:0030916	27	0.050	Zebrafish
establishment of localization	GO:0051234	244	0.050
regulation of biological quality	GO:0065008	263	0.050
outflow tract morphogenesis	GO:0003151	1	0.049
glial cell development	GO:0021782	20	0.048
cartilage morphogenesis	GO:0060536	13	0.048
protein import	GO:0017038	3	0.047
rhombomere 6 development	GO:0021572	4	0.047
fatty acid oxidation	GO:0019395	1	0.047
regulation of axon extension	GO:0030516	24	0.047
cell growth	GO:0016049	57	0.047
regulation of developmental process	GO:0050793	247	0.047	Mouse
regulation of multicellular organism growth	GO:0040014	4	0.047
cellular response to external stimulus	GO:0071496	2	0.046
single organism metabolic process	GO:0044710	217	0.045
palate development	GO:0060021	8	0.045
semicircular canal formation	GO:0060876	4	0.045
organic acid metabolic process	GO:0006082	31	0.045
heart contraction	GO:0060047	71	0.045
determination of dorsal ventral asymmetry	GO:0048262	34	0.045
cellular response to endogenous stimulus	GO:0071495	68	0.044
pericardium development	GO:0060039	1	0.044
regulation of stem cell proliferation	GO:0072091	2	0.043
lipid metabolic process	GO:0006629	52	0.043
heart looping	GO:0001947	94	0.043
cellular catabolic process	GO:0044248	27	0.043
glial cell migration	GO:0008347	3	0.043
collagen metabolic process	GO:0032963	2	0.043
determination of ventral identity	GO:0048264	21	0.043
negative regulation of growth rate	GO:0045967	1	0.043
single organism transport	GO:0044765	206	0.043
positive regulation of metabolic process	GO:0009893	108	0.042	Mouse
immune system development	GO:0002520	191	0.042
collagen fibril organization	GO:0030199	1	0.042
embryonic hemopoiesis	GO:0035162	53	0.042
stem cell division	GO:0017145	1	0.042
heart morphogenesis	GO:0003007	156	0.041
regulation of heart contraction	GO:0008016	32	0.041
embryonic camera type eye morphogenesis	GO:0048596	19	0.041	Zebrafish
oxoacid metabolic process	GO:0043436	31	0.041
hematopoietic or lymphoid organ development	GO:0048534	191	0.041
growth	GO:0040007	174	0.041
notch signaling pathway	GO:0007219	35	0.040
fin development	GO:0033333	77	0.040
response to radiation	GO:0009314	51	0.040
morphogenesis of an epithelial fold	GO:0060571	1	0.040
pectoral fin development	GO:0033339	50	0.039
hindbrain development	GO:0030902	91	0.039	Zebrafish
gastrulation	GO:0007369	208	0.039
regulation of multicellular organismal development	GO:2000026	223	0.039	Mouse
retinal rod cell development	GO:0046548	4	0.039
vestibular receptor cell development	GO:0060118	3	0.038	Zebrafish
negative regulation of apoptotic process	GO:0043066	55	0.038
neural tube patterning	GO:0021532	33	0.038	Zebrafish
chemosensory behavior	GO:0007635	1	0.038
specification of organ position	GO:0010159	3	0.037
response to hormone	GO:0009725	48	0.037
somite development	GO:0061053	96	0.037
negative regulation of nucleobase containing compound metabolic process	GO:0045934	59	0.037	Human
response to light stimulus	GO:0009416	46	0.037
regulation of cartilage development	GO:0061035	7	0.037
chemotaxis	GO:0006935	104	0.036
intracellular signal transduction	GO:0035556	85	0.036
response to hypoxia	GO:0001666	25	0.036
specification of organ axis polarity	GO:0010084	2	0.035
positive regulation of heart contraction	GO:0045823	2	0.035
system process	GO:0003008	185	0.035
establishment of protein localization to organelle	GO:0072594	4	0.034
organic acid catabolic process	GO:0016054	3	0.034
pronephric nephron development	GO:0039019	14	0.034	Zebrafish
lipid catabolic process	GO:0016042	4	0.034
negative regulation of rna biosynthetic process	GO:1902679	45	0.034	Human
positive regulation of apoptotic process	GO:0043065	29	0.034
negative regulation of striated muscle tissue development	GO:0045843	2	0.034
protein import into nucleus	GO:0006606	3	0.034
septum transversum development	GO:0003343	4	0.033
inner ear receptor cell fate commitment	GO:0060120	4	0.033
negative regulation of protein phosphorylation	GO:0001933	4	0.033
limb morphogenesis	GO:0035108	7	0.033
bmp signaling pathway involved in determination of left right symmetry	GO:0003154	14	0.033
myeloid cell differentiation	GO:0030099	86	0.033
regulation of transcription from rna polymerase ii promoter involved in heart development	GO:1901213	15	0.033
cardiocyte differentiation	GO:0035051	44	0.033
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	22	0.033	Mouse
positive regulation of response to stimulus	GO:0048584	80	0.033
developmental maturation	GO:0021700	34	0.032
regulation of axonogenesis	GO:0050770	32	0.032
heart process	GO:0003015	71	0.032
otic vesicle development	GO:0071599	42	0.032	Zebrafish
homeostasis of number of cells	GO:0048872	62	0.031
neuron projection extension	GO:1990138	45	0.031
proepicardium development	GO:0003342	4	0.031
regulation of sodium ion transport	GO:0002028	2	0.031
regulation of localization	GO:0032879	104	0.031
cellular response to molecule of bacterial origin	GO:0071219	3	0.031
regulation of production of molecular mediator of immune response	GO:0002700	1	0.031
positive regulation of signal transduction	GO:0009967	56	0.030
germ line stem cell maintenance	GO:0030718	2	0.030
defense response	GO:0006952	47	0.030
regulation of protein transport	GO:0051223	3	0.030
ion transport	GO:0006811	114	0.029
carboxylic acid metabolic process	GO:0019752	22	0.029
regulation of response to stimulus	GO:0048583	269	0.029
heart development	GO:0007507	313	0.029
sequestering of metal ion	GO:0051238	3	0.029
catecholamine metabolic process	GO:0006584	2	0.029
determination of bilateral symmetry	GO:0009855	204	0.029
metal ion transport	GO:0030001	58	0.029
response to vitamin	GO:0033273	3	0.029
negative regulation of nitrogen compound metabolic process	GO:0051172	59	0.029	Human
central nervous system neuron differentiation	GO:0021953	74	0.029
aging	GO:0007568	2	0.029
positive regulation of erk1 and erk2 cascade	GO:0070374	2	0.029
negative regulation of gene expression	GO:0010629	65	0.028	Human
protein targeting to nucleus	GO:0044744	3	0.028
embryonic skeletal joint development	GO:0072498	3	0.028
positive regulation of programmed cell death	GO:0043068	29	0.028
embryonic digestive tract morphogenesis	GO:0048557	3	0.028
determination of left right symmetry	GO:0007368	179	0.028
positive regulation of signaling	GO:0023056	56	0.027
regulation of cell cycle	GO:0051726	52	0.027
embryonic neurocranium morphogenesis	GO:0048702	15	0.027
regulation of calcium ion transport	GO:0051924	2	0.027
pathway restricted smad protein phosphorylation	GO:0060389	1	0.027
negative regulation of cellular process	GO:0048523	283	0.027	Human
death	GO:0016265	121	0.027
cardiogenic plate morphogenesis	GO:0003142	1	0.027
determination of heart left right asymmetry	GO:0061371	117	0.027
pronephros development	GO:0048793	69	0.027	Zebrafish
developmental cell growth	GO:0048588	52	0.026
glomerulus development	GO:0032835	27	0.026	Zebrafish
negative regulation of map kinase activity	GO:0043407	2	0.025
regulation of blood pressure	GO:0008217	1	0.025
diencephalon development	GO:0021536	58	0.025
positive regulation of cellular component biogenesis	GO:0044089	3	0.025
embryonic heart tube development	GO:0035050	133	0.025
negative regulation of heart contraction	GO:0045822	2	0.025
production of molecular mediator of immune response	GO:0002440	2	0.025
glial cell differentiation	GO:0010001	42	0.025
regulation of extrinsic apoptotic signaling pathway	GO:2001236	3	0.025
nucleocytoplasmic transport	GO:0006913	4	0.025
negative regulation of developmental process	GO:0051093	65	0.025
rostrocaudal neural tube patterning	GO:0021903	29	0.025	Zebrafish
catechol containing compound metabolic process	GO:0009712	2	0.025
cellular component movement	GO:0006928	335	0.024
negative regulation of macromolecule metabolic process	GO:0010605	76	0.024	Human
myotube differentiation	GO:0014902	45	0.024
positive regulation of cell differentiation	GO:0045597	30	0.024
catechol containing compound biosynthetic process	GO:0009713	2	0.024
regulation of establishment of protein localization	GO:0070201	4	0.024
digestive tract development	GO:0048565	265	0.024
camera type eye photoreceptor cell differentiation	GO:0060219	19	0.024
regulation of intracellular protein transport	GO:0033157	3	0.024
cation transport	GO:0006812	81	0.023
cranial nerve development	GO:0021545	42	0.023
positive regulation of catabolic process	GO:0009896	4	0.023
regulation of cytoplasmic transport	GO:1903649	4	0.023
behavior	GO:0007610	74	0.023
tissue regeneration	GO:0042246	74	0.023
positive regulation of secretion by cell	GO:1903532	1	0.023
neuron development	GO:0048666	262	0.023	Zebrafish
positive regulation of cellular metabolic process	GO:0031325	94	0.023	Mouse
adenohypophysis development	GO:0021984	15	0.023
regulation of organ morphogenesis	GO:2000027	35	0.023	Mouse
cell fate commitment	GO:0045165	99	0.023	Zebrafish
pancreas development	GO:0031016	84	0.023
morphogenesis of a branching structure	GO:0001763	21	0.023
negative regulation of immune system process	GO:0002683	7	0.023
optomotor response	GO:0071632	1	0.022
bmp signaling pathway	GO:0030509	52	0.022
compound eye development	GO:0048749	2	0.022
fin morphogenesis	GO:0033334	53	0.022
pons development	GO:0021548	11	0.022
positive regulation of secretion	GO:0051047	1	0.022
regulation of reproductive process	GO:2000241	4	0.022
protein localization	GO:0008104	40	0.022
protein metabolic process	GO:0019538	183	0.022
cardiac muscle tissue development	GO:0048738	48	0.022
negative regulation of metabolic process	GO:0009892	86	0.022	Human
small molecule catabolic process	GO:0044282	3	0.021
regulation of oocyte development	GO:0060281	3	0.021
regulation of angiogenesis	GO:0045765	26	0.021
negative regulation of muscle tissue development	GO:1901862	2	0.021
meiotic chromosome segregation	GO:0045132	3	0.021
negative regulation of epithelial cell proliferation	GO:0050680	1	0.021
epithelial tube morphogenesis	GO:0060562	148	0.021
response to external biotic stimulus	GO:0043207	97	0.021
multicellular organismal metabolic process	GO:0044236	2	0.021
regulation of transport	GO:0051049	45	0.021
collagen biosynthetic process	GO:0032964	2	0.021
glucocorticoid metabolic process	GO:0008211	2	0.021
pronephric glomerulus development	GO:0039021	13	0.021	Zebrafish
nuclear transport	GO:0051169	4	0.021
positive regulation of muscle organ development	GO:0048636	1	0.021
cellular ketone metabolic process	GO:0042180	11	0.020
membrane repolarization	GO:0086009	2	0.020
regulation of vasculature development	GO:1901342	33	0.020
positive regulation of cell communication	GO:0010647	56	0.020
positive regulation of extrinsic apoptotic signaling pathway	GO:2001238	1	0.020
mesodermal to mesenchymal transition involved in gastrulation	GO:0060809	1	0.020
negative regulation of cell cycle	GO:0045786	14	0.020
regulation of cell size	GO:0008361	29	0.020
multicellular organismal macromolecule metabolic process	GO:0044259	2	0.020
serotonin metabolic process	GO:0042428	1	0.020
extrinsic apoptotic signaling pathway in absence of ligand	GO:0097192	1	0.020
specification of axis polarity	GO:0065001	4	0.020
skeletal muscle organ development	GO:0060538	78	0.020
phosphorus metabolic process	GO:0006793	109	0.020
regulation of vascular endothelial growth factor receptor signaling pathway	GO:0030947	8	0.020
myotube cell development	GO:0014904	35	0.020
endocrine system development	GO:0035270	65	0.020	Zebrafish
cardiac muscle cell differentiation	GO:0055007	30	0.020
cellular localization	GO:0051641	97	0.019
negative regulation of macromolecule biosynthetic process	GO:0010558	48	0.019	Human
neurotransmitter transport	GO:0006836	2	0.019
cellular response to growth factor stimulus	GO:0071363	39	0.019	Mouse
atrial ventricular junction remodeling	GO:0003294	2	0.019
homeostatic process	GO:0042592	142	0.019
regulation of cell morphogenesis involved in differentiation	GO:0010769	38	0.019
midbrain hindbrain boundary development	GO:0030917	23	0.019	Zebrafish
nerve development	GO:0021675	45	0.019
digestive tract mesoderm development	GO:0007502	1	0.019
regulation of bone mineralization	GO:0030500	2	0.019
embryonic heart tube morphogenesis	GO:0003143	108	0.019
meiotic nuclear division	GO:0007126	4	0.018
positive regulation of neuron death	GO:1901216	1	0.018
auditory receptor cell fate specification	GO:0042667	2	0.018
regulation of cellular ketone metabolic process	GO:0010565	7	0.018
regulation of cell growth	GO:0001558	29	0.018
positive regulation of cell adhesion	GO:0045785	1	0.018
response to bacterium	GO:0009617	58	0.018
regulation of notch signaling pathway	GO:0008593	16	0.018
regulation of bone remodeling	GO:0046850	2	0.018
single organism reproductive process	GO:0044702	40	0.018
cell cell signaling	GO:0007267	52	0.018
developmental growth	GO:0048589	166	0.018
regulation of positive chemotaxis	GO:0050926	4	0.018
oocyte maturation	GO:0001556	4	0.017
hepaticobiliary system development	GO:0061008	98	0.017
response to external stimulus	GO:0009605	264	0.017	Zebrafish
central nervous system neuron development	GO:0021954	29	0.017
regulation of cell differentiation	GO:0045595	142	0.017
response to endogenous stimulus	GO:0009719	83	0.017
mesoderm morphogenesis	GO:0048332	51	0.017
negative regulation of cellular metabolic process	GO:0031324	77	0.017	Human
forebrain neuron fate commitment	GO:0021877	1	0.017
atrial cardiac muscle cell differentiation	GO:0055011	5	0.017
negative regulation of biosynthetic process	GO:0009890	55	0.017	Human
wound healing	GO:0042060	90	0.017
cell cycle arrest	GO:0007050	1	0.017
sequestering of calcium ion	GO:0051208	3	0.017
dopamine metabolic process	GO:0042417	2	0.017
immune response	GO:0006955	28	0.017

pax9 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease	DO term ID	Probability	Func Analog Org
disease of anatomical entity	DOID:7	0.125	Human
connective tissue disease	DOID:65	0.025
musculoskeletal system disease	DOID:17	0.025
bone disease	DOID:0080001	0.025

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