Danio rerio

0 known processes

spc25

SPC25, NDC80 kinetochore complex component, homolog (S. cerevisiae)

(Aliases: zgc:171542,im:6902492)

spc25 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
larval developmentGO:000216420.126
agingGO:000756820.057
nitrogen compound metabolic processGO:00068073190.052
cellular macromolecule metabolic processGO:00442603910.048
cellular nitrogen compound metabolic processGO:00346412900.047
organic cyclic compound metabolic processGO:19013603010.046
nucleocytoplasmic transportGO:000691340.045
maintenance of locationGO:005123540.045
regulation of macromolecule metabolic processGO:00602553170.040
multicellular organism growthGO:003526440.040
meiotic nuclear divisionGO:000712640.039
cellular aromatic compound metabolic processGO:00067252950.039
nuclear transportGO:005116940.039
regulation of metabolic processGO:00192223590.038
organic substance biosynthetic processGO:19015762890.037
regulation of multicellular organism growthGO:004001440.037
amine metabolic processGO:000930820.037
heterocycle metabolic processGO:00464832900.036
regulation of nitrogen compound metabolic processGO:00511712510.036
establishment of protein localization to organelleGO:007259440.036
positive regulation of cell cycleGO:004578730.035
cellular amine metabolic processGO:004410620.035
positive regulation of transportGO:005105020.035
macromolecule biosynthetic processGO:00090592270.034
positive regulation of cellular component biogenesisGO:004408930.034
nucleobase containing compound metabolic processGO:00061392740.033
phagocytosisGO:000690930.033
gene expressionGO:00104672520.033
nucleic acid metabolic processGO:00903042440.033
cellular nitrogen compound biosynthetic processGO:00442712180.032
regulation of cellular metabolic processGO:00313233200.032
regulation of primary metabolic processGO:00800903110.031
proteolysis involved in cellular protein catabolic processGO:005160330.031
lipid storageGO:001991510.031
regulation of meiotic cell cycleGO:005144510.031
organic cyclic compound biosynthetic processGO:19013622230.031
mitochondrion organizationGO:000700540.030
modification dependent protein catabolic processGO:001994130.030
negative regulation of protein phosphorylationGO:000193340.029
biosynthetic processGO:00090582940.029
regulation of gene expressionGO:00104682650.029
cellular macromolecule biosynthetic processGO:00346452240.029
protein localization to nucleusGO:003450430.029
protein importGO:001703830.029
rna metabolic processGO:00160702190.029
regulation of nucleobase containing compound metabolic processGO:00192192500.029
regulation of biosynthetic processGO:00098892500.029
regulation of cellular amino acid metabolic processGO:000652100.028
regulation of cellular amine metabolic processGO:003323800.028
extrinsic apoptotic signaling pathwayGO:009719130.028
regulation of macromolecule biosynthetic processGO:00105562250.028
regulation of establishment of protein localizationGO:007020140.028
cellular ketone metabolic processGO:0042180110.027
regulation of protein transportGO:005122330.027
organonitrogen compound metabolic processGO:1901564740.027
stem cell maintenanceGO:001982740.027
aromatic compound biosynthetic processGO:00194382170.027
transcription dna templatedGO:00063511810.027
cellular biosynthetic processGO:00442492860.027
negative regulation of biological processGO:00485193040.027
autophagyGO:000691440.027
cellular amino acid metabolic processGO:000652070.027
positive regulation of catabolic processGO:000989640.026
single organism nuclear importGO:190259330.026
nucleic acid templated transcriptionGO:00976591810.026
response to drugGO:004249330.026
positive regulation of cellular catabolic processGO:003133130.026
cell substrate adhesionGO:003158940.026
oxoacid metabolic processGO:0043436310.026
morphogenesis of an epitheliumGO:00020093330.026
regulation of cytokine productionGO:000181730.026
heterocycle biosynthetic processGO:00181302150.026
organic acid metabolic processGO:0006082310.026
cellular protein catabolic processGO:004425740.025
embryo development ending in birth or egg hatchingGO:00097922710.025
regulation of cellular macromolecule biosynthetic processGO:20001122220.025
cognitionGO:005089010.025
cytokinesisGO:000091030.025
proteasomal protein catabolic processGO:001049820.025
regulation of cytoplasmic transportGO:190364940.025
regulation of protein complex assemblyGO:004325430.025
modification dependent macromolecule catabolic processGO:004363230.025
regulation of cellular ketone metabolic processGO:001056570.025
nucleobase containing compound biosynthetic processGO:00346542050.025
gtp catabolic processGO:000618420.025
ubiquitin dependent protein catabolic processGO:000651130.025
rna localizationGO:000640340.025
proteasome mediated ubiquitin dependent protein catabolic processGO:004316120.024
regulation of intracellular protein transportGO:003315730.024
single organism metabolic processGO:00447102170.024
cell surface receptor signaling pathwayGO:00071663250.024
small molecule metabolic processGO:0044281770.024
regulation of cellular biosynthetic processGO:00313262450.024
regulation of autophagyGO:001050630.024
carboxylic acid metabolic processGO:0019752220.024
negative regulation of cellular processGO:00485232830.024
protein import into nucleusGO:000660630.023
regulation of cell shapeGO:000836010.023
female sex differentiationGO:004666040.023
protein metabolic processGO:00195381830.023
nuclear importGO:005117030.023
meiotic cell cycle processGO:190304630.023
regulation of rna metabolic processGO:00512522240.023
regulation of nucleocytoplasmic transportGO:004682220.023
adult behaviorGO:003053420.022
regulation of protein targetingGO:190353320.022
tube morphogenesisGO:00352393490.022
gtp metabolic processGO:004603940.022
regulation of nucleoside metabolic processGO:000911820.022
regulation of protein catabolic processGO:004217610.022
regulation of metal ion transportGO:001095940.022
rna biosynthetic processGO:00327741810.022
response to stressGO:00069502630.022
guanosine containing compound metabolic processGO:190106840.022
protein targeting to nucleusGO:004474430.022
cellular response to external stimulusGO:007149620.022
digestive system developmentGO:00551232890.022
regulation of bindingGO:005109830.022
organelle organizationGO:00069962270.022
regulation of reactive oxygen species metabolic processGO:200037720.022
regulation of mrna processingGO:005068430.021
locomotionGO:00400113130.021
cellular component morphogenesisGO:00329893360.021
nuclear exportGO:005116810.021
establishment of localizationGO:00512342440.021
regulation of protein localization to nucleusGO:190018020.021
regulation of biological qualityGO:00650082630.021
cell cycle g1 s phase transitionGO:004484310.021
microtubule organizing center organizationGO:003102310.021
embryonic organ developmentGO:00485683810.021
signal transductionGO:00071654550.021
regulation of cell activationGO:005086510.021
eye developmentGO:00016542770.021
guanosine containing compound catabolic processGO:190106920.021
regulation of nucleotide catabolic processGO:003081120.021
cellular response to nutrient levelsGO:003166920.021
regulation of purine nucleotide catabolic processGO:003312120.020
cellular response to extracellular stimulusGO:003166820.020
positive regulation of cellular amino acid metabolic processGO:004576400.020
negative regulation of catabolic processGO:000989530.020
positive regulation of translationGO:004572710.020
sensory organ developmentGO:00074233930.020
cell morphogenesisGO:00009022890.020
cellular component disassemblyGO:002241110.020
ribonucleoside monophosphate catabolic processGO:000915840.020
positive regulation of biological processGO:00485182530.020
regulation of nucleic acid templated transcriptionGO:19035062130.020
synaptic growth at neuromuscular junctionGO:005112420.020
response to carbohydrateGO:000974330.019
regulation of peptidyl tyrosine phosphorylationGO:005073010.019
regulation of response to stimulusGO:00485832690.019
regulation of proteolysis involved in cellular protein catabolic processGO:190305010.019
negative regulation of kinase activityGO:003367340.019
cellular component movementGO:00069283350.019
response to chemicalGO:00422213200.019
regulation of protein modification by small protein conjugation or removalGO:190332030.019
protein acetylationGO:000647320.019
positive regulation of cellular amine metabolic processGO:003324000.019
atp catabolic processGO:000620040.019
single organism organelle organizationGO:19025891990.019
regulation of developmental processGO:00507932470.019
positive regulation of cellular processGO:00485222010.019
g1 s transition of mitotic cell cycleGO:000008210.019
blood vessel morphogenesisGO:00485142160.018
regulation of synapse organizationGO:005080730.018
regulation of protein import into nucleusGO:004230620.018
negative regulation of cellular catabolic processGO:003133030.018
single organism localizationGO:19025782250.018
regulation of gtp catabolic processGO:003312420.018
cell projection morphogenesisGO:00488582440.018
nucleoside monophosphate catabolic processGO:000912540.018
vasculature developmentGO:00019442780.018
purine ribonucleoside monophosphate catabolic processGO:000916940.018
regulation of multicellular organismal processGO:00512392770.018
neuron differentiationGO:00301823530.018
protein complex disassemblyGO:004324110.017
cell migrationGO:00164772370.017
blood vessel developmentGO:00015682460.017
i kappab kinase nf kappab signalingGO:000724940.017
protein polymerizationGO:005125840.017
leukocyte proliferationGO:007066110.017
response to external stimulusGO:00096052640.017
stem cell proliferationGO:007208940.017
generation of neuronsGO:00486993850.017
internal peptidyl lysine acetylationGO:001839320.017
positive regulation of protein complex assemblyGO:003133420.017
regulation of dna replicationGO:000627530.017
positive regulation of cytokine productionGO:000181920.017
regulation of signalingGO:00230512350.017
cellular response to oxygen levelsGO:007145310.017
negative regulation of metabolic processGO:0009892860.017
endosomal transportGO:001619720.017
peptidyl lysine acetylationGO:001839420.017
cell matrix adhesionGO:000716040.017
single organism transportGO:00447652060.017
transcription from rna polymerase ii promoterGO:0006366800.017
cellular response to light stimulusGO:007148240.017
meiotic chromosome segregationGO:004513230.016
central nervous system developmentGO:00074173870.016
mitotic dna integrity checkpointGO:004477440.016
cellular component biogenesisGO:00440851780.016
purine nucleoside monophosphate catabolic processGO:000912840.016
regulation of reproductive processGO:200024140.016
regulation of rna biosynthetic processGO:20011412130.016
cytoskeleton dependent cytokinesisGO:006164030.016
positive regulation of secretionGO:005104710.016
cell part morphogenesisGO:00329902460.016
regulation of gtpase activityGO:004308720.016
regulation of transcription dna templatedGO:00063552130.016
cell projection organizationGO:00300302840.016
positive regulation of purine nucleotide catabolic processGO:003312310.016
response to nutrientGO:000758430.016
female gonad developmentGO:000858540.016
development of primary female sexual characteristicsGO:004654540.016
transportGO:00068102200.016
regulation of erk1 and erk2 cascadeGO:007037240.016
regulation of cell communicationGO:00106462320.016
cellular response to starvationGO:000926710.016
regulation of protein ubiquitinationGO:003139630.015
growthGO:00400071740.015
adherens junction organizationGO:003433240.015
erk1 and erk2 cascadeGO:007037140.015
double strand break repairGO:000630230.015
regionalizationGO:00030022740.015
regulation of sequestering of calcium ionGO:005128240.015
internal protein amino acid acetylationGO:000647520.015
immune system processGO:00023762410.015
regulation of cellular protein catabolic processGO:190336210.015
positive regulation of gtp catabolic processGO:003312610.015
primary neural tube formationGO:001402010.015
protein stabilizationGO:005082120.015
regulation of mrna splicing via spliceosomeGO:004802430.015
positive regulation of cytoskeleton organizationGO:005149530.015
centrosome organizationGO:005129710.015
positive regulation of secretion by cellGO:190353210.015
multicellular organismal metabolic processGO:004423620.015
macromolecular complex disassemblyGO:003298410.015
regulation of signal transductionGO:00099662250.015
positive regulation of nucleoside metabolic processGO:004597910.015
cellular carbohydrate metabolic processGO:004426240.015
negative regulation of mapk cascadeGO:004340940.015
symbiosis encompassing mutualism through parasitismGO:004440340.015
regulation of neural precursor cell proliferationGO:200017730.015
negative regulation of protein kinase activityGO:000646940.015
tissue remodelingGO:004877140.015
digestive tract developmentGO:00485652650.015
response to hexoseGO:000974630.015
regulation of i kappab kinase nf kappab signalingGO:004312240.015
response to monosaccharideGO:003428430.015
cellular response to chemical stimulusGO:00708871570.015
heart developmentGO:00075073130.015
muscle structure developmentGO:00610611960.014
protein heterooligomerizationGO:005129110.014
cellular protein metabolic processGO:00442671290.014
hemopoiesisGO:00300971830.014
protein acylationGO:004354330.014
neuron developmentGO:00486662620.014
glucose homeostasisGO:004259310.014
regulation of calcium ion transportGO:005192420.014
regulation of synapse assemblyGO:005196330.014
positive regulation of nucleotide catabolic processGO:003081310.014
camera type eye developmentGO:00430102220.014
single organism membrane fusionGO:004480120.014
cellular component assemblyGO:00226071700.014
secondary metabolic processGO:001974830.014
gastrulationGO:00073692080.014
alternative mrna splicing via spliceosomeGO:000038010.014
sensory organ morphogenesisGO:00905962000.014
sequestering of metal ionGO:005123830.014
response to glucoseGO:000974930.014
phagocytosis engulfmentGO:000691110.014
positive regulation of cytosolic calcium ion concentrationGO:000720440.014
negative regulation of cytokine productionGO:000181810.014
positive regulation of cell activationGO:005086710.014
homeostatic processGO:00425921420.014
regulation of multicellular organismal developmentGO:20000262230.014
negative regulation of protein serine threonine kinase activityGO:007190120.014
response to uvGO:000941130.014
regulation of organ growthGO:004662030.014
post embryonic organ developmentGO:004856940.014
nucleic acid transportGO:005065720.014
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domainsGO:000246040.014
macromolecule modificationGO:00434121110.014
mitotic dna damage checkpointGO:004477340.014
regulation of stem cell proliferationGO:007209120.014
angiogenesisGO:00015251580.014
cellular response to radiationGO:007147840.014
protein secretionGO:000930610.014
centrosome duplicationGO:005129810.014
dna catabolic processGO:000630810.014
telomere maintenanceGO:000072310.014
digestive tract morphogenesisGO:00485462310.014
sequestering of calcium ionGO:005120830.014
positive regulation of immune effector processGO:000269930.014
carbohydrate homeostasisGO:003350010.013
protein localization to plasma membraneGO:007265910.013
membrane fusionGO:006102520.013
spermatid differentiationGO:004851520.013
positive regulation of chromatin modificationGO:190331010.013
positive regulation of dna metabolic processGO:005105410.013
cell motilityGO:00488702440.013
positive regulation of gtpase activityGO:004354710.013
fertilizationGO:000956630.013
negative regulation of dna metabolic processGO:005105340.013
regulation of extrinsic apoptotic signaling pathwayGO:200123630.013
lateral inhibitionGO:004633110.013
regulation of alternative mrna splicing via spliceosomeGO:000038110.013
system processGO:00030081850.013
multi organism cellular processGO:004476420.013
immune system developmentGO:00025201910.013
actin polymerization or depolymerizationGO:000815420.013
protein homooligomerizationGO:005126030.013
programmed cell deathGO:00125011190.013
developmental growthGO:00485891660.013
mononuclear cell proliferationGO:003294310.013
localization of cellGO:00516742440.013
developmental programmed cell deathGO:001062340.013
rna export from nucleusGO:000640510.013
regulation of stem cell differentiationGO:200073640.013
spermatid developmentGO:000728620.013
eye morphogenesisGO:00485921440.013
positive regulation of map kinase activityGO:004340630.013
cell deathGO:00082191210.013
regulation of cell substrate adhesionGO:001081010.013
actin filament polymerizationGO:003004120.013
signal transduction in absence of ligandGO:003803410.013
head developmentGO:00603223030.012
positive regulation of erk1 and erk2 cascadeGO:007037420.012
negative regulation of nuclear divisionGO:005178430.012
membrane invaginationGO:001032410.012
regulation of chromosome segregationGO:005198310.012
brain developmentGO:00074202930.012
response to organic substanceGO:00100331530.012
chordate embryonic developmentGO:00430092710.012
interspecies interaction between organismsGO:004441940.012
regulation of transporter activityGO:003240920.012
viral processGO:001603210.012
peptidyl serine modificationGO:001820920.012
nucleobase containing compound transportGO:001593120.012
negative regulation of nitrogen compound metabolic processGO:0051172590.012
regulation of dendrite developmentGO:005077330.012
production of molecular mediator of immune responseGO:000244020.012
centrosome cycleGO:000709810.012
exocytosisGO:000688710.012
regulation of blood pressureGO:000821710.012
peptidyl serine phosphorylationGO:001810510.012
regulation of inflammatory responseGO:005072720.012
single fertilizationGO:000733830.012
regulation of synaptic growth at neuromuscular junctionGO:000858210.012
dorsal ventral pattern formationGO:00099531250.012
multi organism processGO:00517041340.012
rna modificationGO:000945120.012
activation of mapk activityGO:000018730.012
cellular amide metabolic processGO:004360340.012
b cell activationGO:004211320.012
somatic muscle developmentGO:000752540.012
mitotic cytokinesisGO:000028130.012
response to corticosteroidGO:003196010.012
deathGO:00162651210.012
embryonic organ morphogenesisGO:00485622740.012
small molecule catabolic processGO:004428230.012
intracellular signal transductionGO:0035556850.012
negative regulation of defense responseGO:003134820.012
regulation of anatomical structure morphogenesisGO:00226031300.012
protein polyubiquitinationGO:000020940.012
ovulation cycleGO:004269820.012
somatic stem cell maintenanceGO:003501910.011
negative regulation of sequence specific dna binding transcription factor activityGO:004343320.011
positive regulation of apoptotic signaling pathwayGO:200123510.011
release of sequestered calcium ion into cytosolGO:005120930.011
lymphocyte proliferationGO:004665110.011
peptide transportGO:001583310.011
cytosolic calcium ion transportGO:006040130.011
muscle cell differentiationGO:00426921390.011
negative regulation of gene expressionGO:0010629650.011
rna 3 end processingGO:003112320.011
cellular response to hypoxiaGO:007145610.011
rna transportGO:005065820.011
negative regulation of macromolecule metabolic processGO:0010605760.011
regulation of cellular component organizationGO:0051128860.011
regulation of jak stat cascadeGO:004642530.011
mitochondrial transportGO:000683920.011
hematopoietic or lymphoid organ developmentGO:00485341910.011
regulation of synaptic plasticityGO:004816710.011
meiosis iGO:000712710.011
establishment of rna localizationGO:005123630.011
cellular protein modification processGO:00064641000.011
positive regulation of cell adhesionGO:004578510.011
positive regulation of i kappab kinase nf kappab signalingGO:004312330.011
calcium ion transport into cytosolGO:006040230.011
positive regulation of metabolic processGO:00098931080.011
tube closureGO:006060610.011
phosphate containing compound metabolic processGO:00067961080.011
regulation of dna templated transcription elongationGO:003278430.011
apoptotic processGO:00069151160.011
positive regulation of canonical wnt signaling pathwayGO:009026340.011
lipid catabolic processGO:001604240.011
positive regulation of cell divisionGO:005178120.011
positive regulation of stress activated protein kinase signaling cascadeGO:007030430.011
regulation of dna recombinationGO:000001820.011
organism emergence from protective structureGO:007168440.011
extrinsic apoptotic signaling pathway in absence of ligandGO:009719210.011
regulation of protein complex disassemblyGO:004324410.011
negative regulation of ras protein signal transductionGO:004658010.011
positive regulation of nitrogen compound metabolic processGO:0051173690.011
cell cycle arrestGO:000705010.011
neuron neuron synaptic transmissionGO:000727010.011
negative regulation of cellular metabolic processGO:0031324770.011
regulation of epithelial cell proliferationGO:005067830.011
convergent extensionGO:00600261180.011
axon developmentGO:00615641660.011
cellular response to biotic stimulusGO:007121630.011
organelle fusionGO:004828430.011
negative regulation of secretionGO:005104820.011
ion transportGO:00068111140.011
lipid homeostasisGO:005508830.011
regulation of ion transmembrane transporter activityGO:003241220.011
response to ketoneGO:190165410.011
compound eye developmentGO:004874920.011
positive regulation of stress activated mapk cascadeGO:003287430.011
positive regulation of neuron apoptotic processGO:004352510.010
telomere organizationGO:003220010.010
response to glucocorticoidGO:005138410.010
phosphatidylinositol mediated signalingGO:004801520.010
hormone secretionGO:004687920.010
negative regulation of cytoplasmic transportGO:190365020.010
amino acid transportGO:000686520.010
cellular localizationGO:0051641970.010
inositol lipid mediated signalingGO:004801720.010
cell proliferationGO:0008283800.010
alcohol biosynthetic processGO:004616520.010
cellular response to decreased oxygen levelsGO:003629410.010
g2 dna damage checkpointGO:003157230.010
response to topologically incorrect proteinGO:003596620.010
negative regulation of protein transportGO:005122430.010
regulation of transmembrane transporter activityGO:002289820.010
intracellular mrna localizationGO:000829810.010
negative regulation of signal transductionGO:0009968940.010
regulation of response to biotic stimulusGO:000283120.010
specification of symmetryGO:00097992040.010
negative regulation of mitosisGO:004583930.010
regulation of microtubule cytoskeleton organizationGO:007050730.010
locomotor rhythmGO:004547530.010
cell morphogenesis involved in differentiationGO:00009041950.010
organic acid catabolic processGO:001605430.010
peptidyl lysine methylationGO:001802230.010
anterior posterior pattern specificationGO:00099521520.010

spc25 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.051
musculoskeletal system diseaseDOID:1700.026
nervous system diseaseDOID:86300.022
cancerDOID:16200.017
disease of cellular proliferationDOID:1456600.017
organ system cancerDOID:005068600.016
muscle tissue diseaseDOID:6600.013
muscular diseaseDOID:008000000.013
disease of metabolismDOID:001466700.013
immune system diseaseDOID:291400.012
myopathyDOID:42300.012
cardiovascular system diseaseDOID:128700.011
heart diseaseDOID:11400.011
intrinsic cardiomyopathyDOID:006003600.011
cardiomyopathyDOID:005070000.011
eye diseaseDOID:561400.010
sensory system diseaseDOID:005015500.010
eye and adnexa diseaseDOID:149200.010