IMP: Integrative Multi-species Prediction

Danio rerio

80 known processes

tcf7l1a

transcription factor 7-like 1a (T-cell specific, HMG-box)

(Aliases: tcf-3,tcf3a,tcf3)

Entrez: 30523
Ensembl: ENSDARG00000038159
ZFIN: ZDB-GENE-980605-30
UniProtKB: Q9YHE8

Process Predictions
Disease Predictions

tcf7l1a biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
embryo development ending in birth or egg hatching	GO:0009792	271	0.933
regulation of gene expression	GO:0010468	265	0.881	Zebrafish Mouse Worm Fly
regulation of response to stimulus	GO:0048583	269	0.863
hypothalamus cell differentiation	GO:0021979	4	0.831	Zebrafish
neuron differentiation	GO:0030182	353	0.821	Zebrafish Worm
embryonic organ morphogenesis	GO:0048562	274	0.808
tube morphogenesis	GO:0035239	349	0.720	Zebrafish Worm
head development	GO:0060322	303	0.692
cell fate commitment	GO:0045165	99	0.688	Worm
signal transduction	GO:0007165	455	0.632
sensory organ development	GO:0007423	393	0.615
generation of neurons	GO:0048699	385	0.607
localization of cell	GO:0051674	244	0.599	Zebrafish
neural tube development	GO:0021915	62	0.587
hepaticobiliary system development	GO:0061008	98	0.586
cell surface receptor signaling pathway	GO:0007166	325	0.574
regulation of cellular metabolic process	GO:0031323	320	0.568	Zebrafish Mouse Worm Fly
regulation of macromolecule biosynthetic process	GO:0010556	225	0.556	Mouse Worm Fly
regionalization	GO:0003002	274	0.548
nucleic acid metabolic process	GO:0090304	244	0.537	Mouse Worm Fly
regulation of nervous system development	GO:0051960	90	0.531	Zebrafish
cell morphogenesis involved in neuron differentiation	GO:0048667	163	0.499
cell migration in hindbrain	GO:0021535	7	0.496
organelle organization	GO:0006996	227	0.490	Worm
axon development	GO:0061564	166	0.485
regulation of primary metabolic process	GO:0080090	311	0.480	Zebrafish Mouse Worm Fly
regulation of cell development	GO:0060284	100	0.476	Zebrafish Mouse
canonical wnt signaling pathway	GO:0060070	48	0.475	Zebrafish
cell morphogenesis involved in differentiation	GO:0000904	195	0.467
negative regulation of wnt signaling pathway	GO:0030178	30	0.458
stem cell maintenance	GO:0019827	4	0.443	Mouse
regulation of nucleic acid templated transcription	GO:1903506	213	0.435	Mouse Worm Fly
liver development	GO:0001889	96	0.433
chordate embryonic development	GO:0043009	271	0.404
camera type eye development	GO:0043010	222	0.400
gland development	GO:0048732	143	0.397	Fly
regulation of cell differentiation	GO:0045595	142	0.396	Zebrafish Mouse Worm Fly
cellular macromolecule metabolic process	GO:0044260	391	0.396	Mouse Worm Fly
negative regulation of biological process	GO:0048519	304	0.395
regulation of cell communication	GO:0010646	232	0.389
cell morphogenesis	GO:0000902	289	0.387
anterior posterior pattern specification	GO:0009952	152	0.382
embryonic organ development	GO:0048568	381	0.364
regulation of biosynthetic process	GO:0009889	250	0.361	Zebrafish Mouse Worm Fly
regulation of canonical wnt signaling pathway	GO:0060828	34	0.358
connective tissue development	GO:0061448	99	0.347
organic cyclic compound biosynthetic process	GO:1901362	223	0.342	Mouse Worm Fly
central nervous system development	GO:0007417	387	0.341
digestive tract development	GO:0048565	265	0.338	Zebrafish Worm
wnt signaling pathway	GO:0016055	80	0.336
regulation of stem cell differentiation	GO:2000736	4	0.334	Mouse
positive regulation of cellular process	GO:0048522	201	0.333
neural plate pattern specification	GO:0060896	12	0.333
cellular nitrogen compound metabolic process	GO:0034641	290	0.329	Mouse Worm Fly
gastrulation	GO:0007369	208	0.326	Worm
neuron development	GO:0048666	262	0.324	Worm
somatic stem cell maintenance	GO:0035019	1	0.324	Mouse
primary neural tube formation	GO:0014020	1	0.318
regulation of epithelial cell proliferation	GO:0050678	3	0.315
regulation of cellular macromolecule biosynthetic process	GO:2000112	222	0.312	Mouse Worm Fly
negative regulation of collateral sprouting	GO:0048671	2	0.308
foregut morphogenesis	GO:0007440	4	0.297
diencephalon development	GO:0021536	58	0.287	Zebrafish
digestive tract morphogenesis	GO:0048546	231	0.287	Zebrafish Worm
nuclear transport	GO:0051169	4	0.283
neuron projection morphogenesis	GO:0048812	161	0.280
regulation of meiotic cell cycle	GO:0051445	1	0.270
regulation of transcription dna templated	GO:0006355	213	0.265	Mouse Worm Fly
hindbrain development	GO:0030902	91	0.260	Zebrafish
regulation of developmental process	GO:0050793	247	0.255	Zebrafish Mouse Worm Fly
non canonical wnt signaling pathway	GO:0035567	13	0.254
mesoderm morphogenesis	GO:0048332	51	0.252	Mouse Worm
neural tube patterning	GO:0021532	33	0.252
nucleic acid templated transcription	GO:0097659	181	0.246	Mouse Worm Fly
positive regulation of neurogenesis	GO:0050769	24	0.242	Zebrafish
larval development	GO:0002164	2	0.241	Worm
ameboidal type cell migration	GO:0001667	143	0.240	Zebrafish
skeletal system development	GO:0001501	181	0.238
facial nerve development	GO:0021561	3	0.238
cell part morphogenesis	GO:0032990	246	0.233
regulation of neurogenesis	GO:0050767	87	0.229	Zebrafish
digestive system development	GO:0055123	289	0.225	Zebrafish Worm
brain development	GO:0007420	293	0.223
retinal ganglion cell axon guidance	GO:0031290	35	0.221
regulation of multicellular organismal process	GO:0051239	277	0.219	Zebrafish Mouse Worm Fly
axon guidance	GO:0007411	86	0.219
negative regulation of neuron projection regeneration	GO:0070571	4	0.208
heterocycle metabolic process	GO:0046483	290	0.205	Mouse Worm Fly
mesodermal cell fate specification	GO:0007501	12	0.204
histone modification	GO:0016570	20	0.201
negative regulation of response to stimulus	GO:0048585	104	0.197
diterpenoid metabolic process	GO:0016101	15	0.195	Zebrafish
cellular component morphogenesis	GO:0032989	336	0.195
embryonic eye morphogenesis	GO:0048048	30	0.192
positive regulation of stress activated protein kinase signaling cascade	GO:0070304	3	0.191
transcription dna templated	GO:0006351	181	0.185	Mouse Worm Fly
regulation of rna biosynthetic process	GO:2001141	213	0.183	Mouse Worm Fly
locomotion	GO:0040011	313	0.182	Zebrafish
posterior lateral line neuromast development	GO:0048919	20	0.182	Zebrafish
endocrine system development	GO:0035270	65	0.182
cell projection organization	GO:0030030	284	0.177
embryonic pattern specification	GO:0009880	44	0.172	Zebrafish Mouse Worm Fly
cell projection morphogenesis	GO:0048858	244	0.170
cell migration	GO:0016477	237	0.170	Zebrafish
heart development	GO:0007507	313	0.169	Fly
organic cyclic compound metabolic process	GO:1901360	301	0.168	Mouse Worm Fly
retina development in camera type eye	GO:0060041	146	0.166
radial glial cell differentiation	GO:0060019	2	0.163
wnt signaling pathway involved in digestive tract morphogenesis	GO:0044333	4	0.163	Zebrafish
regulation of nitrogen compound metabolic process	GO:0051171	251	0.161	Mouse Worm Fly
neuroblast proliferation	GO:0007405	2	0.160
gene expression	GO:0010467	252	0.160	Zebrafish Mouse Worm Fly
regulation of cell projection organization	GO:0031344	44	0.160
negative regulation of signal transduction	GO:0009968	94	0.158
convergent extension involved in gastrulation	GO:0060027	71	0.156
cell fate commitment involved in formation of primary germ layer	GO:0060795	26	0.156	Worm
response to oxygen containing compound	GO:1901700	55	0.154
negative regulation of collateral sprouting of intact axon in response to injury	GO:0048685	2	0.151
ear development	GO:0043583	127	0.148
cellular localization	GO:0051641	97	0.146
regulation of collateral sprouting of intact axon in response to injury	GO:0048683	2	0.144
axonogenesis	GO:0007409	152	0.142
rna metabolic process	GO:0016070	219	0.141	Mouse Worm Fly
regulation of nucleobase containing compound metabolic process	GO:0019219	250	0.141	Mouse Worm Fly
cell proliferation	GO:0008283	80	0.139
cell migration involved in gastrulation	GO:0042074	79	0.134
tube closure	GO:0060606	1	0.131
negative regulation of cellular process	GO:0048523	283	0.129
cellular nitrogen compound biosynthetic process	GO:0044271	218	0.129	Mouse Worm Fly
regulation of neuron projection development	GO:0010975	40	0.129
growth	GO:0040007	174	0.126	Zebrafish
macromolecule biosynthetic process	GO:0009059	227	0.126	Mouse Worm Fly
organelle localization	GO:0051640	49	0.125
mesodermal cell differentiation	GO:0048333	21	0.125	Worm
regulation of signal transduction	GO:0009966	225	0.124
formation of primary germ layer	GO:0001704	62	0.124	Worm
regulation of rna metabolic process	GO:0051252	224	0.123	Mouse Worm Fly
rna biosynthetic process	GO:0032774	181	0.122	Mouse Worm Fly
eye development	GO:0001654	277	0.122
epithelial tube morphogenesis	GO:0060562	148	0.122
regulation of neuron differentiation	GO:0045664	56	0.121
nucleobase containing compound biosynthetic process	GO:0034654	205	0.120	Mouse Worm Fly
rna stabilization	GO:0043489	4	0.119
skeletal muscle organ development	GO:0060538	78	0.116
morphogenesis of embryonic epithelium	GO:0016331	30	0.116
neuron projection development	GO:0031175	180	0.115
stem cell proliferation	GO:0072089	4	0.114	Fly
regulation of nucleocytoplasmic transport	GO:0046822	2	0.113
cell cycle process	GO:0022402	53	0.112	Worm
regulation of macromolecule metabolic process	GO:0060255	317	0.111	Zebrafish Mouse Worm Fly
regulation of collateral sprouting in absence of injury	GO:0048696	4	0.111
positive regulation of jun kinase activity	GO:0043507	2	0.110
heart jogging	GO:0003146	40	0.109
nuclear migration	GO:0007097	3	0.109
morphogenesis of an epithelium	GO:0002009	333	0.107
mesoderm development	GO:0007498	88	0.105	Mouse Worm
homeostasis of number of cells within a tissue	GO:0048873	4	0.104	Zebrafish
retinoic acid metabolic process	GO:0042573	9	0.104	Zebrafish
embryonic epithelial tube formation	GO:0001838	17	0.103
nitrogen compound metabolic process	GO:0006807	319	0.103	Mouse Worm Fly
neuron projection regeneration	GO:0031102	16	0.103
hematopoietic or lymphoid organ development	GO:0048534	191	0.102
g1 s transition of mitotic cell cycle	GO:0000082	1	0.100
eye field cell fate commitment involved in camera type eye formation	GO:0060898	3	0.100
regulation of organelle organization	GO:0033043	29	0.098
embryonic skeletal system morphogenesis	GO:0048704	93	0.098
regulation of cellular biosynthetic process	GO:0031326	245	0.098	Zebrafish Mouse Worm Fly
regulation of inner ear receptor cell differentiation	GO:2000980	1	0.096
dorsal ventral pattern formation	GO:0009953	125	0.096	Zebrafish
neuromast development	GO:0048884	46	0.095	Zebrafish
cartilage development	GO:0051216	96	0.094
regulation of cell morphogenesis involved in differentiation	GO:0010769	38	0.094
immune system process	GO:0002376	241	0.094	Fly
cellular response to stress	GO:0033554	62	0.093
cell death	GO:0008219	121	0.093	Worm
cellular macromolecule biosynthetic process	GO:0034645	224	0.092	Mouse Worm Fly
positive regulation of biological process	GO:0048518	253	0.092
response to stress	GO:0006950	263	0.092	Zebrafish
negative regulation of cell communication	GO:0010648	96	0.092
heart looping	GO:0001947	94	0.091
regulation of wnt signaling pathway	GO:0030111	53	0.090
cell substrate adhesion	GO:0031589	4	0.089
endoderm development	GO:0007492	49	0.088
regulation of glial cell differentiation	GO:0045685	4	0.088
skeletal system morphogenesis	GO:0048705	102	0.087
neural crest cell development	GO:0014032	62	0.087	Zebrafish
somitogenesis	GO:0001756	87	0.086	Zebrafish
negative regulation of gene expression	GO:0010629	65	0.086	Mouse Worm Fly
pancreas development	GO:0031016	84	0.085
covalent chromatin modification	GO:0016569	20	0.085
cell substrate junction assembly	GO:0007044	2	0.084
muscle fiber development	GO:0048747	52	0.083	Zebrafish
single organism localization	GO:1902578	225	0.083	Worm
preganglionic parasympathetic nervous system development	GO:0021783	6	0.082
immune response	GO:0006955	28	0.082
positive regulation of biosynthetic process	GO:0009891	68	0.080	Mouse Worm Fly
positive regulation of mesenchymal cell proliferation	GO:0002053	1	0.080
regulation of cell morphogenesis	GO:0022604	42	0.079
optic placode formation	GO:0001743	4	0.079
positive regulation of signal transduction	GO:0009967	56	0.079
sensory system development	GO:0048880	76	0.079	Zebrafish
positive regulation of stem cell proliferation	GO:2000648	1	0.079
stem cell development	GO:0048864	82	0.079	Zebrafish Mouse
oocyte maturation	GO:0001556	4	0.079
extrinsic apoptotic signaling pathway	GO:0097191	3	0.078
cell cycle	GO:0007049	93	0.078	Worm
single organism metabolic process	GO:0044710	217	0.078	Zebrafish
regulation of cell proliferation	GO:0042127	37	0.077
cell fate specification involved in pattern specification	GO:0060573	3	0.077
establishment of protein localization to organelle	GO:0072594	4	0.077
response to chemical	GO:0042221	320	0.077
neural precursor cell proliferation	GO:0061351	20	0.077
regulation of vitamin metabolic process	GO:0030656	6	0.077	Zebrafish
chromatin modification	GO:0016568	21	0.077
somite development	GO:0061053	96	0.076	Zebrafish
cell proliferation in dorsal spinal cord	GO:0010456	2	0.076
actin cytoskeleton organization	GO:0030036	63	0.075
spinal cord development	GO:0021510	46	0.075	Zebrafish
programmed cell death	GO:0012501	119	0.073	Worm
endodermal cell fate determination	GO:0007493	2	0.073
spinal cord radial glial cell differentiation	GO:0021531	2	0.073
lateral inhibition	GO:0046331	1	0.073
embryonic skeletal joint development	GO:0072498	3	0.073
regulation of cellular component organization	GO:0051128	86	0.072
cell surface receptor signaling pathway involved in heart development	GO:0061311	20	0.072
regulation of biological quality	GO:0065008	263	0.072	Zebrafish
myeloid cell differentiation	GO:0030099	86	0.071
positive regulation of embryonic development	GO:0040019	3	0.071
transcription from rna polymerase ii promoter	GO:0006366	80	0.071	Mouse Worm Fly
regulation of synapse assembly	GO:0051963	3	0.069
organic substance biosynthetic process	GO:1901576	289	0.069	Zebrafish Mouse Worm Fly
positive regulation of stress activated mapk cascade	GO:0032874	3	0.069
establishment of localization	GO:0051234	244	0.069	Worm
ectodermal placode formation	GO:0060788	26	0.069
regulation of cell fate commitment	GO:0010453	22	0.068	Worm
regulation of anatomical structure morphogenesis	GO:0022603	130	0.068
positive regulation of cell proliferation	GO:0008284	15	0.068
single organism nuclear import	GO:1902593	3	0.068
system process	GO:0003008	185	0.068	Zebrafish Worm
embryonic skeletal system development	GO:0048706	97	0.068
single organism organelle organization	GO:1902589	199	0.068	Worm
regulation of signaling	GO:0023051	235	0.067
facial nucleus development	GO:0021754	7	0.067
response to axon injury	GO:0048678	14	0.066
mesenchyme development	GO:0060485	127	0.066	Zebrafish
segmentation	GO:0035282	97	0.066	Zebrafish Mouse
regulation of cellular ketone metabolic process	GO:0010565	7	0.065	Zebrafish
establishment or maintenance of epithelial cell apical basal polarity	GO:0045197	11	0.064
proximal distal pattern formation	GO:0009954	1	0.064	Worm
rhombomere boundary formation	GO:0021654	10	0.064
neural crest cell migration	GO:0001755	42	0.062	Zebrafish
neuron projection guidance	GO:0097485	86	0.062
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	22	0.062	Mouse Worm Fly
negative regulation of axon regeneration	GO:0048681	4	0.061
stem cell differentiation	GO:0048863	117	0.061	Zebrafish Mouse
cell fate determination	GO:0001709	7	0.061	Worm
embryonic cranial skeleton morphogenesis	GO:0048701	90	0.059
positive regulation of mesodermal cell fate specification	GO:0048337	1	0.059
fin development	GO:0033333	77	0.059	Zebrafish
histone deacetylation	GO:0016575	2	0.059
eye morphogenesis	GO:0048592	144	0.058
rostrocaudal neural tube patterning	GO:0021903	29	0.058
synaptic transmission	GO:0007268	35	0.057
determination of left right asymmetry in lateral mesoderm	GO:0003140	20	0.057
positive regulation of metabolic process	GO:0009893	108	0.056	Zebrafish Mouse Worm Fly
metencephalon development	GO:0022037	27	0.055
positive regulation of mesoderm development	GO:2000382	1	0.055
regulation of transcription from rna polymerase ii promoter	GO:0006357	114	0.055	Mouse Worm Fly
lateral line system development	GO:0048925	76	0.055	Zebrafish
regulation of organ morphogenesis	GO:2000027	35	0.054
regulation of multicellular organismal development	GO:2000026	223	0.054	Zebrafish Worm
regeneration	GO:0031099	91	0.054	Zebrafish
regulation of stem cell proliferation	GO:0072091	2	0.054	Fly
apoptotic process	GO:0006915	116	0.054	Worm
positive regulation of nervous system development	GO:0051962	25	0.054	Zebrafish
regulation of protein localization to nucleus	GO:1900180	2	0.053
multicellular organismal metabolic process	GO:0044236	2	0.053
nucleobase containing compound metabolic process	GO:0006139	274	0.053	Mouse Worm Fly
neural retina development	GO:0003407	49	0.053
neuron projection extension	GO:1990138	45	0.053
negative regulation of chromosome organization	GO:2001251	1	0.052
positive regulation of notch signaling pathway	GO:0045747	3	0.052
response to lipid	GO:0033993	60	0.052
muscle cell differentiation	GO:0042692	139	0.052	Zebrafish
taxis	GO:0042330	109	0.051
cellular aromatic compound metabolic process	GO:0006725	295	0.051	Mouse Worm Fly
homeostatic process	GO:0042592	142	0.050	Zebrafish
positive regulation of nitrogen compound metabolic process	GO:0051173	69	0.050	Mouse Worm Fly
epithelial tube formation	GO:0072175	19	0.050
axon extension	GO:0048675	45	0.050
inner ear morphogenesis	GO:0042472	63	0.050
optic placode formation involved in camera type eye formation	GO:0046619	3	0.050
mesoderm formation	GO:0001707	43	0.049	Worm
neural tube formation	GO:0001841	16	0.049
skin development	GO:0043588	54	0.048	Mouse
chromosome organization	GO:0051276	31	0.048
negative regulation of chromatin modification	GO:1903309	1	0.047
regulation of intracellular protein transport	GO:0033157	3	0.047
camera type eye photoreceptor cell differentiation	GO:0060219	19	0.047
regulation of skeletal muscle tissue development	GO:0048641	4	0.047
negative regulation of histone modification	GO:0031057	1	0.047
negative regulation of rna metabolic process	GO:0051253	48	0.046	Mouse Worm Fly
macromolecule modification	GO:0043412	111	0.046
proteasome mediated ubiquitin dependent protein catabolic process	GO:0043161	2	0.045
cytoskeleton organization	GO:0007010	96	0.045	Worm
death	GO:0016265	121	0.045	Worm
regulation of binding	GO:0051098	3	0.045
negative regulation of canonical wnt signaling pathway	GO:0090090	21	0.045
developmental growth involved in morphogenesis	GO:0060560	86	0.044
biosynthetic process	GO:0009058	294	0.044	Zebrafish Mouse Worm Fly
appendage morphogenesis	GO:0035107	56	0.044	Zebrafish Fly
sensory neuron axon guidance	GO:0097374	3	0.044
cellular biosynthetic process	GO:0044249	286	0.044	Zebrafish Mouse Worm Fly
positive regulation of neural precursor cell proliferation	GO:2000179	1	0.044
negative regulation of striated muscle cell differentiation	GO:0051154	1	0.043
guanosine containing compound metabolic process	GO:1901068	4	0.042
lateral line development	GO:0048882	66	0.042	Zebrafish
embryonic heart tube development	GO:0035050	133	0.042
positive regulation of epithelial cell proliferation	GO:0050679	1	0.042
regulation of retinoic acid biosynthetic process	GO:1900052	6	0.042	Zebrafish
negative regulation of axon guidance	GO:1902668	1	0.041
protein metabolic process	GO:0019538	183	0.041
spinal cord dorsal ventral patterning	GO:0021513	5	0.041	Zebrafish
cellular component movement	GO:0006928	335	0.040	Zebrafish
positive regulation of cell death	GO:0010942	29	0.040
forebrain anterior posterior pattern specification	GO:0021797	3	0.040
negative regulation of transcription from rna polymerase ii promoter	GO:0000122	16	0.040
negative regulation of multicellular organismal process	GO:0051241	69	0.040	Worm
negative regulation of programmed cell death	GO:0043069	58	0.039
cell motility	GO:0048870	244	0.039	Zebrafish
actin filament organization	GO:0007015	15	0.039
cellular response to molecule of bacterial origin	GO:0071219	3	0.039
response to organic substance	GO:0010033	153	0.039
positive regulation of epithelial cell differentiation	GO:0030858	2	0.038
midbrain development	GO:0030901	28	0.038
regulation of axonogenesis	GO:0050770	32	0.038
striated muscle cell development	GO:0055002	108	0.038	Zebrafish
negative regulation of notch signaling pathway	GO:0045746	6	0.038
regulation of collateral sprouting	GO:0048670	7	0.038
regulation of bmp signaling pathway involved in heart jogging	GO:2000223	12	0.037
bmp signaling pathway	GO:0030509	52	0.037
mitotic cell cycle process	GO:1903047	48	0.037	Worm
pectoral fin development	GO:0033339	50	0.037	Zebrafish
negative regulation of transcription dna templated	GO:0045892	45	0.037	Mouse Worm Fly
synaptic vesicle recycling	GO:0036465	1	0.036
smoothened signaling pathway	GO:0007224	30	0.036
regulation of mechanoreceptor differentiation	GO:0045631	1	0.036
cellular ketone metabolic process	GO:0042180	11	0.036	Zebrafish
regulation of protein metabolic process	GO:0051246	56	0.036
negative regulation of dna metabolic process	GO:0051053	4	0.036
collateral sprouting of intact axon in response to injury	GO:0048673	2	0.036
posttranscriptional gene silencing	GO:0016441	3	0.036	Worm
inner ear development	GO:0048839	126	0.036
trigeminal nerve development	GO:0021559	3	0.036
regulation of extrinsic apoptotic signaling pathway	GO:2001236	3	0.035
cell fate specification	GO:0001708	68	0.035	Worm
neural nucleus development	GO:0048857	15	0.035
cardiac cell fate commitment	GO:0060911	1	0.035
embryonic digestive tract morphogenesis	GO:0048557	3	0.035
response to external stimulus	GO:0009605	264	0.035
positive regulation of macromolecule metabolic process	GO:0010604	93	0.035	Zebrafish Mouse Worm Fly
negative regulation of retinal cell programmed cell death	GO:0046671	2	0.034
formation of anatomical boundary	GO:0048859	14	0.034
regulation of oligodendrocyte differentiation	GO:0048713	1	0.034
diencephalon morphogenesis	GO:0048852	5	0.034
mesenchymal cell proliferation	GO:0010463	1	0.034
developmental growth	GO:0048589	166	0.034	Zebrafish
negative regulation of epithelial cell proliferation	GO:0050680	1	0.034
habenula development	GO:0021986	9	0.034
regulation of dna metabolic process	GO:0051052	11	0.034
ectodermal placode morphogenesis	GO:0071697	32	0.034
notochord development	GO:0030903	54	0.033
regulation of cytokine production	GO:0001817	3	0.033
regulation of mesenchymal cell proliferation	GO:0010464	1	0.033
regulation of mesoderm development	GO:2000380	11	0.033
muscle cell fate determination	GO:0007521	1	0.033
response to inorganic substance	GO:0010035	38	0.032
wnt signaling pathway involved in somitogenesis	GO:0090244	2	0.032
motor neuron axon guidance	GO:0008045	23	0.032
regulation of apoptotic process	GO:0042981	98	0.032
anterior posterior axon guidance	GO:0033564	5	0.032
retina morphogenesis in camera type eye	GO:0060042	79	0.032
single organism cell adhesion	GO:0098602	29	0.032
positive regulation of nucleobase containing compound metabolic process	GO:0045935	69	0.032	Mouse Worm Fly
negative regulation of nucleobase containing compound metabolic process	GO:0045934	59	0.031	Mouse Worm Fly
regulation of mesodermal cell fate specification	GO:0042661	9	0.031
negative regulation of developmental process	GO:0051093	65	0.031	Mouse Worm
regulation of catalytic activity	GO:0050790	55	0.031
macromolecular complex subunit organization	GO:0043933	74	0.031	Worm
notch signaling pathway	GO:0007219	35	0.031
inner ear receptor cell fate commitment	GO:0060120	4	0.030
cell growth	GO:0016049	57	0.030
muscle structure development	GO:0061061	196	0.030	Zebrafish Worm
glial cell differentiation	GO:0010001	42	0.030
wnt signaling pathway planar cell polarity pathway	GO:0060071	4	0.030
phagocytosis engulfment	GO:0006911	1	0.030
positive regulation of cell differentiation	GO:0045597	30	0.030	Zebrafish
skeletal muscle fiber development	GO:0048741	35	0.029
single organism cellular localization	GO:1902580	46	0.029
axon regeneration	GO:0031103	14	0.029
chromatin organization	GO:0006325	22	0.029
negative regulation of signaling	GO:0023057	96	0.029
tube formation	GO:0035148	25	0.029
meiotic nuclear division	GO:0007126	4	0.029
mrna stabilization	GO:0048255	4	0.029
regulation of cell death	GO:0010941	103	0.029
autonomic nervous system development	GO:0048483	19	0.029
camera type eye morphogenesis	GO:0048593	108	0.029
axis specification	GO:0009798	43	0.029	Mouse Worm
regulation of bmp signaling pathway	GO:0030510	39	0.029
determination of bilateral symmetry	GO:0009855	204	0.029
heterocycle biosynthetic process	GO:0018130	215	0.029	Mouse Worm Fly
medulla oblongata development	GO:0021550	4	0.029
regulation of transcription from rna polymerase ii promoter involved in determination of left right symmetry	GO:1900094	17	0.028
cellular response to endogenous stimulus	GO:0071495	68	0.028
blood vessel development	GO:0001568	246	0.028
cellular response to organic substance	GO:0071310	105	0.028
retinal pigment epithelium development	GO:0003406	8	0.028
central nervous system neuron differentiation	GO:0021953	74	0.027	Zebrafish
response to wounding	GO:0009611	116	0.027	Zebrafish
macromolecule deacylation	GO:0098732	3	0.027
cellular component biogenesis	GO:0044085	178	0.027
positive regulation of oocyte development	GO:0060282	1	0.027
actin filament based process	GO:0030029	64	0.027
regulation of dna replication	GO:0006275	3	0.027
multi organism process	GO:0051704	134	0.027
mesodermal cell migration	GO:0008078	12	0.027
establishment of cell polarity	GO:0030010	18	0.027
body morphogenesis	GO:0010171	16	0.026
mitotic cell cycle	GO:0000278	64	0.026	Worm
collateral sprouting	GO:0048668	9	0.026
positive regulation of nucleic acid templated transcription	GO:1903508	57	0.026	Mouse Worm Fly
regulation of chromatin modification	GO:1903308	5	0.026
sex determination	GO:0007530	1	0.026
regulation of cell shape	GO:0008360	1	0.026
regulation of organ growth	GO:0046620	3	0.025
positive regulation of cellular component biogenesis	GO:0044089	3	0.025
guanosine containing compound catabolic process	GO:1901069	2	0.025
regulation of protein import into nucleus	GO:0042306	2	0.025
nucleocytoplasmic transport	GO:0006913	4	0.025
intracellular signal transduction	GO:0035556	85	0.025
establishment or maintenance of cell polarity	GO:0007163	29	0.025
regulation of gtp catabolic process	GO:0033124	2	0.025
cranial nerve development	GO:0021545	42	0.025
protein localization to nucleus	GO:0034504	3	0.024
hemopoiesis	GO:0030097	183	0.024
positive regulation of transport	GO:0051050	2	0.024
epithelial cell differentiation	GO:0030855	116	0.024
muscle organ development	GO:0007517	101	0.024	Worm
negative regulation of extrinsic apoptotic signaling pathway	GO:2001237	2	0.024
branchiomotor neuron axon guidance	GO:0021785	1	0.024
appendage development	GO:0048736	80	0.023	Zebrafish Fly
otic placode formation	GO:0043049	23	0.023
regulation of programmed cell death	GO:0043067	101	0.023
regulation of axon regeneration	GO:0048679	7	0.023
peripheral nervous system neuron axonogenesis	GO:0048936	13	0.023
synaptic vesicle endocytosis	GO:0048488	1	0.023
negative regulation of nuclear division	GO:0051784	3	0.023
epithelial cell morphogenesis	GO:0003382	2	0.023
mesenchymal cell differentiation	GO:0048762	87	0.023	Zebrafish
positive regulation of rna metabolic process	GO:0051254	59	0.023	Mouse Worm Fly
protein complex subunit organization	GO:0071822	46	0.023	Worm
post anal tail morphogenesis	GO:0036342	19	0.023
olfactory bulb development	GO:0021772	4	0.023
cell cell recognition	GO:0009988	1	0.023
gtp metabolic process	GO:0046039	4	0.022
cell fate commitment involved in pattern specification	GO:0060581	6	0.022
fertilization	GO:0009566	3	0.022
positive regulation of cell cycle	GO:0045787	3	0.022
cellular protein modification process	GO:0006464	100	0.022
gene silencing by rna	GO:0031047	4	0.022	Worm
regulation of skeletal muscle fiber development	GO:0048742	2	0.022
glossopharyngeal nerve development	GO:0021563	1	0.022
negative regulation of rna biosynthetic process	GO:1902679	45	0.022	Mouse Worm Fly
fibroblast growth factor receptor signaling pathway	GO:0008543	22	0.022
regulation of response to stress	GO:0080134	36	0.022
peripheral nervous system neuron development	GO:0048935	22	0.022
cardiac atrium morphogenesis	GO:0003209	2	0.022
negative regulation of gliogenesis	GO:0014014	1	0.022
regulation of histone modification	GO:0031056	5	0.022
cellular protein metabolic process	GO:0044267	129	0.022
regulation of neural retina development	GO:0061074	2	0.021
establishment of localization in cell	GO:0051649	77	0.021
negative regulation of reproductive process	GO:2000242	3	0.021
otic vesicle development	GO:0071599	42	0.021
facial nerve morphogenesis	GO:0021610	1	0.021
negative regulation of smoothened signaling pathway	GO:0045879	6	0.021
negative regulation of stem cell differentiation	GO:2000737	2	0.021
regulation of establishment of planar polarity	GO:0090175	4	0.021
regulation of endothelial cell differentiation	GO:0045601	3	0.021
heart morphogenesis	GO:0003007	156	0.021
maintenance of location	GO:0051235	4	0.021
embryonic neurocranium morphogenesis	GO:0048702	15	0.021

tcf7l1a disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease	DO term ID	Probability
electroclinical syndrome	DOID:0050701	0.031
disease of anatomical entity	DOID:7	0.031
nervous system disease	DOID:863	0.031
brain disease	DOID:936	0.031
central nervous system disease	DOID:331	0.031
epilepsy syndrome	DOID:1826	0.031

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