Danio rerio

0 known processes

map2k6

mitogen-activated protein kinase kinase 6

(Aliases: map2k3,zMKK3,MKK3)

map2k6 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
larval developmentGO:000216420.186
Worm
regulation of metabolic processGO:00192223590.185
Human Zebrafish Mouse Worm
regionalizationGO:00030022740.150
Zebrafish
meiotic nuclear divisionGO:000712640.126
synaptic growth at neuromuscular junctionGO:005112420.113
regulation of developmental processGO:00507932470.113
organic substance biosynthetic processGO:19015762890.110
Human Mouse Worm
multi organism processGO:00517041340.109
Worm
cellular biosynthetic processGO:00442492860.104
Human Mouse Worm
stem cell maintenanceGO:001982740.103
regulation of macromolecule biosynthetic processGO:00105562250.102
Human Mouse Worm
positive regulation of cellular component biogenesisGO:004408930.100
developmental growthGO:00485891660.097
regulation of nitrogen compound metabolic processGO:00511712510.097
Human Worm
cell migrationGO:00164772370.097
single organism organelle organizationGO:19025891990.088
locomotionGO:00400113130.087
regulation of gene expressionGO:00104682650.086
Human Worm
regulation of dna replicationGO:000627530.080
localization of cellGO:00516742440.079
positive regulation of jun kinase activityGO:004350720.078
Zebrafish
positive regulation of catabolic processGO:000989640.078
response to stressGO:00069502630.076
Zebrafish Mouse Worm
response to external stimulusGO:00096052640.075
Worm
mitotic dna integrity checkpointGO:004477440.074
nitrogen compound metabolic processGO:00068073190.073
Human Worm
positive regulation of biological processGO:00485182530.073
Human Zebrafish Mouse Worm
regulation of biological qualityGO:00650082630.072
multicellular organism growthGO:003526440.071
cellular macromolecule biosynthetic processGO:00346452240.071
Human Worm
regulation of multicellular organism growthGO:004001440.070
cellular macromolecule metabolic processGO:00442603910.070
Human Zebrafish Mouse Worm
regulation of macromolecule metabolic processGO:00602553170.069
Human Zebrafish Mouse Worm
response to abiotic stimulusGO:00096281220.066
positive regulation of canonical wnt signaling pathwayGO:009026340.066
organelle organizationGO:00069962270.066
agingGO:000756820.066
negative regulation of multicellular organismal processGO:0051241690.065
biosynthetic processGO:00090582940.064
Human Mouse Worm
mitotic g2 m transition checkpointGO:004481830.064
central nervous system developmentGO:00074173870.064
response to uvGO:000941130.062
behaviorGO:0007610740.061
Worm
cellular process involved in reproduction in multicellular organismGO:0022412280.060
cellular nitrogen compound metabolic processGO:00346412900.059
Human Worm
positive regulation of protein complex assemblyGO:003133420.059
regulation of mrna splicing via spliceosomeGO:004802430.059
embryonic organ developmentGO:00485683810.058
stem cell divisionGO:001714510.058
regulation of transcription dna templatedGO:00063552130.057
Human Worm
cell surface receptor signaling pathwayGO:00071663250.055
positive regulation of multicellular organismal processGO:0051240520.055
Worm
gene expressionGO:00104672520.054
Human Worm
stem cell proliferationGO:007208940.054
negative regulation of kinase activityGO:003367340.054
mitotic cell cycleGO:0000278640.054
cell cycle g1 s phase transitionGO:004484310.053
oogenesisGO:0048477140.053
regulation of cellular macromolecule biosynthetic processGO:20001122220.053
Human Worm
regulation of cellular component organizationGO:0051128860.053
stem cell developmentGO:0048864820.052
nucleic acid metabolic processGO:00903042440.052
Human Worm
neuroblast proliferationGO:000740520.051
lamellipodium assemblyGO:003003210.051
cell cycleGO:0007049930.050
regulation of multicellular organismal processGO:00512392770.050
Mouse Worm
mesenchymal cell differentiationGO:0048762870.049
stem cell differentiationGO:00488631170.048
regulation of alternative mrna splicing via spliceosomeGO:000038110.048
dorsal ventral pattern formationGO:00099531250.048
Zebrafish
cell motilityGO:00488702440.047
cell projection organizationGO:00300302840.046
meiotic cell cycle processGO:190304630.046
regulation of protein import into nucleusGO:004230620.045
signal transductionGO:00071654550.045
Zebrafish Mouse Worm
cell cycle processGO:0022402530.045
embryo development ending in birth or egg hatchingGO:00097922710.045
Zebrafish
response to radiationGO:0009314510.044
chordate embryonic developmentGO:00430092710.044
Zebrafish
regulation of cytoplasmic transportGO:190364940.044
head developmentGO:00603223030.044
regulation of cellular biosynthetic processGO:00313262450.043
Human Mouse Worm
neuron differentiationGO:00301823530.043
regulation of protein complex assemblyGO:004325430.043
response to chemicalGO:00422213200.042
Worm
cytoskeleton organizationGO:0007010960.042
negative regulation of response to stimulusGO:00485851040.042
positive regulation of cellular processGO:00485222010.041
Human Zebrafish Mouse Worm
muscle structure developmentGO:00610611960.041
mitotic g2 dna damage checkpointGO:000709530.041
negative regulation of mitotic cell cycleGO:0045930110.040
growthGO:00400071740.040
regulation of cell cycleGO:0051726520.040
negative regulation of protein phosphorylationGO:000193340.039
axon developmentGO:00615641660.039
regulation of multicellular organismal developmentGO:20000262230.039
organic cyclic compound metabolic processGO:19013603010.038
Human Worm
nuclear importGO:005117030.038
cellular response to stressGO:0033554620.038
Zebrafish Worm
regulation of cell communicationGO:00106462320.038
Zebrafish Mouse Worm
regulation of nucleic acid templated transcriptionGO:19035062130.038
Human Worm
regulation of nucleobase containing compound metabolic processGO:00192192500.038
Human Worm
generation of neuronsGO:00486993850.038
regulation of rna metabolic processGO:00512522240.037
Human Worm
protein localization to nucleusGO:003450430.036
heart developmentGO:00075073130.036
g1 s transition of mitotic cell cycleGO:000008210.035
system processGO:00030081850.035
Mouse
negative regulation of macromolecule metabolic processGO:0010605760.035
regulation of protein catabolic processGO:004217610.035
single organism nuclear importGO:190259330.035
negative regulation of protein kinase activityGO:000646940.035
single organism metabolic processGO:00447102170.035
Zebrafish Mouse Worm
regulation of protein ubiquitinationGO:003139630.035
regulation of response to stimulusGO:00485832690.034
Zebrafish Mouse Worm
somitogenesisGO:0001756870.034
Zebrafish
mesenchymal cell developmentGO:0014031780.034
translational initiationGO:000641330.034
regulation of synapse assemblyGO:005196330.034
nuclear transportGO:005116940.033
reproductionGO:0000003400.033
Worm
cellular component movementGO:00069283350.033
protein polymerizationGO:005125840.033
axonogenesisGO:00074091520.032
cellular component assemblyGO:00226071700.032
regulation of jun kinase activityGO:004350630.032
Zebrafish
negative regulation of cell cycleGO:0045786140.032
axon guidanceGO:0007411860.031
positive regulation of cellular catabolic processGO:003133130.031
cellular component morphogenesisGO:00329893360.031
regulation of establishment of protein localizationGO:007020140.031
intracellular signal transductionGO:0035556850.031
Zebrafish Mouse Worm
multi organism reproductive processGO:0044703360.031
Worm
mesoderm developmentGO:0007498880.031
specification of organ identityGO:001009220.031
transcription from rna polymerase ii promoterGO:0006366800.031
Worm
regulation of mitotic cell cycleGO:0007346250.031
cell deathGO:00082191210.031
regulation of protein transportGO:005122330.031
post anal tail morphogenesisGO:0036342190.031
locomotor rhythmGO:004547530.030
protein importGO:001703830.030
cellular component biogenesisGO:00440851780.030
establishment of protein localization to organelleGO:007259440.030
positive regulation of map kinase activityGO:004340630.030
Zebrafish Mouse Worm
spermatid differentiationGO:004851520.029
response to light stimulusGO:0009416460.029
regulation of signal transductionGO:00099662250.029
Zebrafish Mouse Worm
negative regulation of synapse assemblyGO:005196420.029
sister chromatid cohesionGO:000706220.029
positive regulation of stem cell proliferationGO:200064810.029
cognitionGO:005089010.029
regulation of rna biosynthetic processGO:20011412130.029
Human Worm
apoptotic processGO:00069151160.028
regulation of cell activationGO:005086510.028
negative regulation of developmental processGO:0051093650.028
lamellipodium organizationGO:009758110.028
regulation of chromosome segregationGO:005198310.028
regulation of synapse organizationGO:005080730.028
brain developmentGO:00074202930.028
negative regulation of dna metabolic processGO:005105340.028
meiosis iGO:000712710.027
maintenance of locationGO:005123540.027
protein import into nucleusGO:000660630.027
nucleocytoplasmic transportGO:000691340.027
regulation of nucleocytoplasmic transportGO:004682220.027
nucleobase containing compound metabolic processGO:00061392740.027
Human Worm
negative regulation of biological processGO:00485193040.027
gastrulationGO:00073692080.027
regulation of catalytic activityGO:0050790550.026
Human Zebrafish Mouse Worm
single organism reproductive processGO:0044702400.026
alternative mrna splicing via spliceosomeGO:000038010.026
forebrain developmentGO:0030900960.026
epidermis developmentGO:0008544480.026
heterocycle biosynthetic processGO:00181302150.026
Human Worm
protein targeting to nucleusGO:004474430.026
multicellular organism reproductionGO:0032504350.026
Worm
g2 dna damage checkpointGO:003157230.025
negative regulation of signal transductionGO:0009968940.025
organelle fissionGO:0048285230.025
regulation of cell proliferationGO:0042127370.025
regulation of cell cycle processGO:0010564200.025
negative regulation of cellular processGO:00485232830.025
cell fate commitmentGO:0045165990.025
regulation of cell shapeGO:000836010.025
mitotic dna damage checkpointGO:004477340.025
mesenchyme developmentGO:00604851270.025
cellular aromatic compound metabolic processGO:00067252950.025
Human Worm
positive regulation of cell communicationGO:0010647560.025
Zebrafish Mouse Worm
regulation of cell differentiationGO:00455951420.025
rna biosynthetic processGO:00327741810.024
Human Worm
neuron projection developmentGO:00311751800.024
regulation of peptidyl tyrosine phosphorylationGO:005073010.024
negative regulation of metabolic processGO:0009892860.024
regulation of biosynthetic processGO:00098892500.024
Human Mouse Worm
phagocytosisGO:000690930.024
negative regulation of cellular metabolic processGO:0031324770.024
mitotic cell cycle processGO:1903047480.024
neural tube patterningGO:0021532330.023
protein metabolic processGO:00195381830.023
Human Zebrafish Mouse Worm
regulation of cellular amino acid metabolic processGO:000652100.023
positive regulation of jnk cascadeGO:004633030.023
Zebrafish
cell projection morphogenesisGO:00488582440.023
cellular amine metabolic processGO:004410620.023
cellular response to chemical stimulusGO:00708871570.022
regulation of molecular functionGO:0065009700.022
Human Zebrafish Mouse Worm
cellular response to dna damage stimulusGO:0006974240.022
germ cell developmentGO:0007281220.022
muscle cell differentiationGO:00426921390.022
mononuclear cell proliferationGO:003294310.022
negative regulation of macromolecule biosynthetic processGO:0010558480.022
muscle organ developmentGO:00075171010.022
embryonic organ morphogenesisGO:00485622740.022
nucleobase containing compound biosynthetic processGO:00346542050.022
Human Worm
regulation of synaptic growth at neuromuscular junctionGO:000858210.022
aromatic compound biosynthetic processGO:00194382170.022
Human Worm
nucleic acid templated transcriptionGO:00976591810.021
Human Worm
b cell activationGO:004211320.021
inner ear developmentGO:00488391260.021
cellular response to external stimulusGO:007149620.021
cell part morphogenesisGO:00329902460.021
transcription dna templatedGO:00063511810.021
Human Worm
lipid storageGO:001991510.021
rna metabolic processGO:00160702190.021
Human Worm
cell morphogenesis involved in differentiationGO:00009041950.021
eye developmentGO:00016542770.020
meiotic chromosome segregationGO:004513230.020
autophagyGO:000691440.020
negative regulation of defense responseGO:003134820.020
positive regulation of apoptotic signaling pathwayGO:200123510.020
hematopoietic or lymphoid organ developmentGO:00485341910.020
positive regulation of developmental processGO:0051094500.020
protein stabilizationGO:005082120.020
regulation of cyclin dependent protein serine threonine kinase activityGO:000007910.020
cell morphogenesis involved in neuron differentiationGO:00486671630.020
macromolecule biosynthetic processGO:00090592270.020
Human Mouse Worm
anterior posterior pattern specificationGO:00099521520.020
Zebrafish
regulation of cellular amine metabolic processGO:003323800.020
cellular protein metabolic processGO:00442671290.020
Human Zebrafish Mouse Worm
amine metabolic processGO:000930820.020
programmed cell deathGO:00125011190.020
neuromuscular synaptic transmissionGO:000727420.020
cellular response to hormone stimulusGO:0032870390.020
regulation of signalingGO:00230512350.020
Zebrafish Mouse Worm
positive regulation of neural precursor cell proliferationGO:200017910.019
actin filament polymerizationGO:003004120.019
skeletal muscle organ developmentGO:0060538780.019
cellular nitrogen compound biosynthetic processGO:00442712180.019
Human Worm
extrinsic apoptotic signaling pathwayGO:009719130.019
negative regulation of dna replicationGO:000815620.019
regulation of bindingGO:005109830.019
neuron projection morphogenesisGO:00488121610.019
sexual reproductionGO:0019953360.018
skin developmentGO:0043588540.018
cellular response to nutrient levelsGO:003166920.018
mitotic cell cycle phase transitionGO:004477290.018
negative regulation of signalingGO:0023057960.018
cellular response to extracellular stimulusGO:003166820.018
transportGO:00068102200.018
central nervous system neuron differentiationGO:0021953740.018
posttranscriptional regulation of gene expressionGO:0010608140.018
regulation of stem cell proliferationGO:007209120.018
heterocycle metabolic processGO:00464832900.018
Human Worm
segmentationGO:0035282970.018
Zebrafish
positive regulation of cell cycleGO:004578730.018
regulation of protein localization to nucleusGO:190018020.018
wnt signaling pathwayGO:0016055800.018
cellular response to biotic stimulusGO:007121630.018
negative regulation of nucleobase containing compound metabolic processGO:0045934590.018
neurotransmitter transportGO:000683620.018
b cell differentiationGO:003018310.018
epithelial cell differentiationGO:00308551160.017
cellular response to starvationGO:000926710.017
embryonic limb morphogenesisGO:003032620.017
cellular amino acid metabolic processGO:000652070.017
regulation of intracellular protein transportGO:003315730.017
regulation of cellular ketone metabolic processGO:001056570.017
regulation of mrna processingGO:005068430.017
somite developmentGO:0061053960.017
Zebrafish
regulation of response to cytokine stimulusGO:006075930.017
rna processingGO:0006396250.017
forebrain regionalizationGO:002187140.017
positive regulation of nitrogen compound metabolic processGO:0051173690.017
Human Worm
leukocyte proliferationGO:007066110.017
positive regulation of striated muscle tissue developmentGO:004584410.017
negative regulation of cell cycle processGO:001094890.017
regulation of establishment of planar polarityGO:009017540.017
gamete generationGO:0007276330.017
negative regulation of cell differentiationGO:0045596460.017
ameboidal type cell migrationGO:00016671430.017
immune system developmentGO:00025201910.016
regulation of protein polymerizationGO:003227120.016
membrane invaginationGO:001032410.016
organic cyclic compound biosynthetic processGO:19013622230.016
Human Worm
spindle assemblyGO:005122520.016
dorsal ventral axis specificationGO:0009950140.016
rostrocaudal neural tube patterningGO:0021903290.016
chemotaxisGO:00069351040.016
regulation of protein modification by small protein conjugation or removalGO:190332030.016
response to drugGO:004249330.016
regulation of reproductive processGO:200024140.016
Worm
ribonucleoside monophosphate catabolic processGO:000915840.016
regulation of programmed cell deathGO:00430671010.016
negative regulation of cellular macromolecule biosynthetic processGO:2000113480.016
phosphorus metabolic processGO:00067931090.016
Human Zebrafish Mouse Worm
phagocytosis engulfmentGO:000691110.016
single organism localizationGO:19025782250.016
regulation of mitotic cell cycle phase transitionGO:190199080.016
regulation of protein targetingGO:190353320.016
positive regulation of rna metabolic processGO:0051254590.016
Human Worm
blood vessel morphogenesisGO:00485142160.016
response to external biotic stimulusGO:0043207970.016
Worm
actin cytoskeleton organizationGO:0030036630.015
negative regulation of chromosome organizationGO:200125110.015
cell morphogenesisGO:00009022890.015
macroautophagyGO:001623610.015
positive regulation of metabolic processGO:00098931080.015
Human Zebrafish Mouse Worm
tube morphogenesisGO:00352393490.015
positive regulation of protein polymerizationGO:003227320.015
establishment of localizationGO:00512342440.015
cell proliferation in forebrainGO:002184630.015
positive regulation of extrinsic apoptotic signaling pathwayGO:200123810.015
striated muscle tissue developmentGO:00147061100.015
extrinsic apoptotic signaling pathway via death domain receptorsGO:000862510.015
regulation of developmental growthGO:0048638380.015
organonitrogen compound metabolic processGO:1901564740.014
lymphocyte proliferationGO:004665110.014
response to other organismGO:0051707970.014
Worm
purine ribonucleoside monophosphate catabolic processGO:000916940.014
oocyte maturationGO:000155640.014
taxisGO:00423301090.014
cellular ketone metabolic processGO:0042180110.014
rna localizationGO:000640340.014
determination of bilateral symmetryGO:00098552040.014
Zebrafish
neural crest cell differentiationGO:0014033720.014
determination of left right symmetryGO:00073681790.014
homeostatic processGO:00425921420.014
regulation of neural precursor cell proliferationGO:200017730.014
oxoacid metabolic processGO:0043436310.014
neurotransmitter secretionGO:000726920.014
cardiac cell fate commitmentGO:006091110.014
deathGO:00162651210.014
positive regulation of cellular amine metabolic processGO:003324000.014
regulation of cellular metabolic processGO:00313233200.014
Human Zebrafish Mouse Worm
mesenchymal cell proliferationGO:001046310.014
spermatid developmentGO:000728620.014
somatic muscle developmentGO:000752540.014
secondary metabolic processGO:001974830.014
regulation of meiotic cell cycleGO:005144510.014
positive regulation of cell activationGO:005086710.014
i kappab kinase nf kappab signalingGO:000724940.013
regulation of organelle assemblyGO:190211540.013
regulation of extrinsic apoptotic signaling pathwayGO:200123630.013
regulation of phosphorus metabolic processGO:0051174430.013
Human Zebrafish Mouse Worm
macromolecule modificationGO:00434121110.013
Human Zebrafish Mouse Worm
urogenital system developmentGO:0001655970.013
carboxylic acid metabolic processGO:0019752220.013
negative regulation of nitrogen compound metabolic processGO:0051172590.013
adult behaviorGO:003053420.013
peptide metabolic processGO:000651810.013
canonical wnt signaling pathwayGO:0060070480.013
enzyme linked receptor protein signaling pathwayGO:00071671060.013
wnt signaling pathway planar cell polarity pathwayGO:006007140.013
regulation of cell deathGO:00109411030.013
cellular amide metabolic processGO:004360340.013
positive regulation of cytoskeleton organizationGO:005149530.013
hemopoiesisGO:00300971830.013
neural tube developmentGO:0021915620.013
response to biotic stimulusGO:0009607970.013
Worm
regulation of organelle organizationGO:0033043290.013
cell fate specificationGO:0001708680.013
positive regulation of transportGO:005105020.012
circadian sleep wake cycle sleepGO:005080210.012
sensory perception of touchGO:005097520.012
sensory organ morphogenesisGO:00905962000.012
single organism biosynthetic processGO:0044711710.012
actin polymerization or depolymerizationGO:000815420.012
regulation of apoptotic processGO:0042981980.012
regulation of cellular protein catabolic processGO:190336210.012
digestive tract morphogenesisGO:00485462310.012
forebrain cell migrationGO:002188510.012
regulation of growthGO:0040008420.012
vasculature developmentGO:00019442780.012
internal protein amino acid acetylationGO:000647520.012
nucleus organizationGO:000699770.012
neuron projection guidanceGO:0097485860.012
positive regulation of cellular metabolic processGO:0031325940.012
Human Zebrafish Mouse Worm
organic acid metabolic processGO:0006082310.012
negative regulation of protein serine threonine kinase activityGO:007190120.012
development of primary female sexual characteristicsGO:004654540.012
lateral inhibitionGO:004633110.012
regulation of microtubule cytoskeleton organizationGO:007050730.012
dna templated transcription initiationGO:000635210.012
cellular component disassemblyGO:002241110.012
multicellular organismal reproductive processGO:0048609350.011
Worm
regulation of proteolysis involved in cellular protein catabolic processGO:190305010.011
chemosensory behaviorGO:000763510.011
dna catabolic processGO:000630810.011
embryonic digestive tract morphogenesisGO:004855730.011
blood vessel developmentGO:00015682460.011
positive regulation of biosynthetic processGO:0009891680.011
Human Worm
positive regulation of response to stimulusGO:0048584800.011
Zebrafish Mouse Worm
female gamete generationGO:0007292140.011
cell divisionGO:0051301200.011
heart morphogenesisGO:00030071560.011
reproductive processGO:0022414400.011
Worm
muscle tissue developmentGO:00605371100.011
positive regulation of muscle organ developmentGO:004863610.011
regulation of protein metabolic processGO:0051246560.011
Human Zebrafish Mouse Worm
activation of mapk activityGO:000018730.011
Zebrafish Mouse Worm
somatic stem cell maintenanceGO:003501910.011
response to carbohydrateGO:000974330.011
positive regulation of epithelial cell proliferationGO:005067910.011
regulation of cell cycle phase transitionGO:190198780.011
negative regulation of gene expressionGO:0010629650.011
positive regulation of muscle tissue developmentGO:190186310.011
ear morphogenesisGO:0042471640.011
tissue remodelingGO:004877140.011
negative regulation of cell cycle phase transitionGO:190198850.011
small molecule metabolic processGO:0044281770.011
digestive system developmentGO:00551232890.011
negative regulation of myeloid cell differentiationGO:004563810.011
purine nucleoside monophosphate catabolic processGO:000912840.011
female sex differentiationGO:004666040.011
dna metabolic processGO:0006259270.011
positive regulation of muscle cell differentiationGO:005114910.011
hepaticobiliary system developmentGO:0061008980.011
regulation of embryonic developmentGO:0045995470.010
determination of heart left right asymmetryGO:00613711170.010
cell cycle phase transitionGO:004477090.010
response to steroid hormoneGO:0048545350.010
regulation of epithelial cell proliferationGO:005067830.010
negative regulation of cell communicationGO:0010648960.010
nuclear divisionGO:0000280230.010
detection of mechanical stimulus involved in sensory perception of touchGO:005097620.010
megakaryocyte differentiationGO:003021910.010
female gonad developmentGO:000858540.010
maternal determination of anterior posterior axis embryoGO:000835840.010
negative regulation of cellular biosynthetic processGO:0031327550.010
axis specificationGO:0009798430.010
rna polyadenylationGO:004363120.010
startle responseGO:000196440.010
regulation of nucleoside metabolic processGO:000911820.010
negative regulation of map kinase activityGO:004340720.010
embryonic skeletal system morphogenesisGO:0048704930.010

map2k6 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
nervous system diseaseDOID:86300.031
disease of anatomical entityDOID:700.031