IMP: Integrative Multi-species Prediction

Danio rerio

28 known processes

ikzf1

IKAROS family zinc finger 1 (Ikaros)

(Aliases: ikaros,znfn1a1)

Entrez: 30177
Ensembl: ENSDARG00000013539
ZFIN: ZDB-GENE-980526-304
UniProtKB: O93581

Process Predictions
Disease Predictions

ikzf1 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
hematopoietic or lymphoid organ development	GO:0048534	191	0.995
immune system development	GO:0002520	191	0.988
hemopoiesis	GO:0030097	183	0.956
regulation of leukocyte differentiation	GO:1902105	5	0.925	Mouse
homeostasis of number of cells	GO:0048872	62	0.914
immune system process	GO:0002376	241	0.901
regulation of nitrogen compound metabolic process	GO:0051171	251	0.871	Mouse
regulation of multicellular organismal process	GO:0051239	277	0.848	Mouse
gene expression	GO:0010467	252	0.796	Mouse
regulation of neutrophil differentiation	GO:0045658	3	0.785	Mouse
regulation of primary metabolic process	GO:0080090	311	0.755	Mouse
regulation of cellular macromolecule biosynthetic process	GO:2000112	222	0.751	Mouse
epithelial cell differentiation	GO:0030855	116	0.744
negative regulation of biological process	GO:0048519	304	0.739	Mouse
lymphocyte differentiation	GO:0030098	9	0.719
heterocycle metabolic process	GO:0046483	290	0.704	Mouse
cellular macromolecule metabolic process	GO:0044260	391	0.646	Mouse
gland development	GO:0048732	143	0.620	Mouse
actin filament based process	GO:0030029	64	0.608
embryonic hemopoiesis	GO:0035162	53	0.601
erythrocyte differentiation	GO:0030218	54	0.600
macromolecular complex subunit organization	GO:0043933	74	0.591
organic cyclic compound biosynthetic process	GO:1901362	223	0.589	Mouse
negative regulation of developmental process	GO:0051093	65	0.567
tissue remodeling	GO:0048771	4	0.561
histone h3 k4 methylation	GO:0051568	2	0.559
erythrocyte homeostasis	GO:0034101	55	0.549
leukocyte differentiation	GO:0002521	25	0.535
negative regulation of macromolecule metabolic process	GO:0010605	76	0.526	Mouse
regulation of metabolic process	GO:0019222	359	0.525	Mouse
regulation of multicellular organismal development	GO:2000026	223	0.490	Mouse
regulation of cellular metabolic process	GO:0031323	320	0.488	Mouse
eye development	GO:0001654	277	0.486	Mouse
regulation of peptidyl tyrosine phosphorylation	GO:0050730	1	0.480
positive regulation of cellular metabolic process	GO:0031325	94	0.467	Mouse
macromolecule biosynthetic process	GO:0009059	227	0.459	Mouse
nitrogen compound metabolic process	GO:0006807	319	0.449	Mouse
hematopoietic stem cell migration	GO:0035701	4	0.438
regulation of macromolecule metabolic process	GO:0060255	317	0.437	Mouse
cellular aromatic compound metabolic process	GO:0006725	295	0.431	Mouse
regulation of developmental process	GO:0050793	247	0.425	Mouse
cell migration	GO:0016477	237	0.424
cellular ketone metabolic process	GO:0042180	11	0.420
negative regulation of multicellular organismal process	GO:0051241	69	0.413
transcription dna templated	GO:0006351	181	0.410	Mouse
chromosome organization	GO:0051276	31	0.406
cellular macromolecule biosynthetic process	GO:0034645	224	0.403	Mouse
positive regulation of cell activation	GO:0050867	1	0.393	Mouse
myeloid leukocyte differentiation	GO:0002573	15	0.390	Mouse
lymphocyte activation	GO:0046649	10	0.386
regulation of cell differentiation	GO:0045595	142	0.384	Mouse
heterocycle biosynthetic process	GO:0018130	215	0.384	Mouse
myeloid cell differentiation	GO:0030099	86	0.378	Mouse
striated muscle tissue development	GO:0014706	110	0.376
definitive hemopoiesis	GO:0060216	18	0.373
angiogenesis	GO:0001525	158	0.369
cellular nitrogen compound metabolic process	GO:0034641	290	0.358	Mouse
regulation of macromolecule biosynthetic process	GO:0010556	225	0.358	Mouse
leukocyte homeostasis	GO:0001776	2	0.349
rna metabolic process	GO:0016070	219	0.345	Mouse
positive regulation of biological process	GO:0048518	253	0.319	Mouse
amine metabolic process	GO:0009308	2	0.315
protein complex subunit organization	GO:0071822	46	0.305
blood vessel development	GO:0001568	246	0.304
regulation of erythrocyte differentiation	GO:0045646	2	0.302
death	GO:0016265	121	0.293
locomotion	GO:0040011	313	0.289
cellular protein metabolic process	GO:0044267	129	0.288
cell morphogenesis involved in neuron differentiation	GO:0048667	163	0.287
heart development	GO:0007507	313	0.286
embryonic organ development	GO:0048568	381	0.286
regulation of rna biosynthetic process	GO:2001141	213	0.285	Mouse
organic cyclic compound metabolic process	GO:1901360	301	0.283	Mouse
biosynthetic process	GO:0009058	294	0.276	Mouse
cellular component morphogenesis	GO:0032989	336	0.267
cell morphogenesis	GO:0000902	289	0.259
regulation of nucleic acid templated transcription	GO:1903506	213	0.258	Mouse
establishment of localization in cell	GO:0051649	77	0.256
response to biotic stimulus	GO:0009607	97	0.255
negative regulation of gene expression	GO:0010629	65	0.255	Mouse
erythrocyte maturation	GO:0043249	8	0.250
positive regulation of cellular amino acid metabolic process	GO:0045764	0	0.249
embryonic heart tube development	GO:0035050	133	0.249
cellular component assembly	GO:0022607	170	0.246
tube morphogenesis	GO:0035239	349	0.243
ventricular cardiac muscle cell development	GO:0055015	5	0.240
digestive system development	GO:0055123	289	0.231
t cell differentiation in thymus	GO:0033077	6	0.230
regulation of cellular component organization	GO:0051128	86	0.228
cellular response to endogenous stimulus	GO:0071495	68	0.226
negative regulation of biosynthetic process	GO:0009890	55	0.225	Mouse
thymus development	GO:0048538	10	0.224	Mouse
vasculature development	GO:0001944	278	0.223
cell death	GO:0008219	121	0.221
cell morphogenesis involved in differentiation	GO:0000904	195	0.219
positive regulation of cytokine production	GO:0001819	2	0.218
axonal defasciculation	GO:0007414	2	0.218
cell projection organization	GO:0030030	284	0.218
negative regulation of cellular process	GO:0048523	283	0.216	Mouse
phagocytosis	GO:0006909	3	0.214
erythrocyte development	GO:0048821	24	0.213
response to chemical	GO:0042221	320	0.210
stem cell proliferation	GO:0072089	4	0.207
regulation of apoptotic process	GO:0042981	98	0.206
regulation of biological quality	GO:0065008	263	0.206
cellular amine metabolic process	GO:0044106	2	0.203
organic substance biosynthetic process	GO:1901576	289	0.201	Mouse
negative regulation of nitrogen compound metabolic process	GO:0051172	59	0.195	Mouse
regulation of biosynthetic process	GO:0009889	250	0.191	Mouse
myeloid cell homeostasis	GO:0002262	56	0.187
regulation of cell activation	GO:0050865	1	0.185	Mouse
regulation of cellular amino acid metabolic process	GO:0006521	0	0.184
multicellular organismal metabolic process	GO:0044236	2	0.184
chemotaxis	GO:0006935	104	0.184
negative regulation of cellular biosynthetic process	GO:0031327	55	0.184	Mouse
positive regulation of cellular amine metabolic process	GO:0033240	0	0.183
axon guidance	GO:0007411	86	0.179
lens fiber cell development	GO:0070307	3	0.177
regulation of response to stimulus	GO:0048583	269	0.177
negative regulation of protein phosphorylation	GO:0001933	4	0.177
regulation of cell death	GO:0010941	103	0.173
rna biosynthetic process	GO:0032774	181	0.173	Mouse
positive regulation of nucleobase containing compound metabolic process	GO:0045935	69	0.172	Mouse
regulation of gene expression	GO:0010468	265	0.168	Mouse
homeostatic process	GO:0042592	142	0.163
regulation of stem cell proliferation	GO:0072091	2	0.162
central nervous system development	GO:0007417	387	0.160	Mouse
digestive tract development	GO:0048565	265	0.155
regulation of histone methylation	GO:0031060	3	0.155
regulation of programmed cell death	GO:0043067	101	0.154
positive regulation of apoptotic signaling pathway	GO:2001235	1	0.153
cellular component movement	GO:0006928	335	0.152
camera type eye development	GO:0043010	222	0.151	Mouse
nuclear transport	GO:0051169	4	0.151
digestive tract morphogenesis	GO:0048546	231	0.149
defense response	GO:0006952	47	0.149
regulation of cytokine production	GO:0001817	3	0.147
positive regulation of biosynthetic process	GO:0009891	68	0.146	Mouse
apoptotic process	GO:0006915	116	0.137
macromolecular complex assembly	GO:0065003	35	0.137
response to bacterium	GO:0009617	58	0.137
generation of neurons	GO:0048699	385	0.135
primitive erythrocyte differentiation	GO:0060319	5	0.135
cellular nitrogen compound biosynthetic process	GO:0044271	218	0.134	Mouse
neuron development	GO:0048666	262	0.133
muscle structure development	GO:0061061	196	0.132
organonitrogen compound metabolic process	GO:1901564	74	0.132
neuron differentiation	GO:0030182	353	0.131
negative regulation of metabolic process	GO:0009892	86	0.130	Mouse
cell motility	GO:0048870	244	0.129
regulation of establishment of protein localization	GO:0070201	4	0.127
regulation of anatomical structure morphogenesis	GO:0022603	130	0.127
regulation of cellular biosynthetic process	GO:0031326	245	0.126	Mouse
positive regulation of cell death	GO:0010942	29	0.125
cell surface receptor signaling pathway	GO:0007166	325	0.124
mesenchymal cell differentiation	GO:0048762	87	0.123
positive regulation of developmental process	GO:0051094	50	0.122	Mouse
regulation of nucleobase containing compound metabolic process	GO:0019219	250	0.121	Mouse
nucleocytoplasmic transport	GO:0006913	4	0.121
positive regulation of locomotion	GO:0040017	14	0.119
sprouting angiogenesis	GO:0002040	53	0.119
leukocyte activation	GO:0045321	12	0.116
carboxylic acid metabolic process	GO:0019752	22	0.114
granulocyte differentiation	GO:0030851	8	0.111	Mouse
cytokinesis	GO:0000910	3	0.110
localization of cell	GO:0051674	244	0.110
cell projection morphogenesis	GO:0048858	244	0.110
small molecule metabolic process	GO:0044281	77	0.109
regulation of extrinsic apoptotic signaling pathway	GO:2001236	3	0.109
gastrulation	GO:0007369	208	0.108
cytoskeleton organization	GO:0007010	96	0.107
regulation of epithelial cell proliferation	GO:0050678	3	0.105
dorsal aorta morphogenesis	GO:0035912	3	0.105
regulation of cell shape	GO:0008360	1	0.104
regulation of translational initiation	GO:0006446	1	0.104
response to organic substance	GO:0010033	153	0.104
oxoacid metabolic process	GO:0043436	31	0.103
cellular biosynthetic process	GO:0044249	286	0.103	Mouse
stem cell differentiation	GO:0048863	117	0.101
single organismal cell cell adhesion	GO:0016337	29	0.101
protein modification process	GO:0036211	100	0.100
nucleic acid metabolic process	GO:0090304	244	0.100	Mouse
regulation of homeostatic process	GO:0032844	9	0.100
lymphatic endothelial cell differentiation	GO:0060836	1	0.098
aromatic compound biosynthetic process	GO:0019438	217	0.098	Mouse
actin cytoskeleton organization	GO:0030036	63	0.097
cell division	GO:0051301	20	0.094
liver development	GO:0001889	96	0.094
cellular component biogenesis	GO:0044085	178	0.093
regulation of signaling	GO:0023051	235	0.092
primitive hemopoiesis	GO:0060215	27	0.092
larval development	GO:0002164	2	0.091
regulation of immune system process	GO:0002682	34	0.090	Mouse
response to amino acid	GO:0043200	2	0.089
neuroblast proliferation	GO:0007405	2	0.087
regulation of cellular amine metabolic process	GO:0033238	0	0.085
brain development	GO:0007420	293	0.084	Mouse
macromolecule modification	GO:0043412	111	0.084
response to oxygen containing compound	GO:1901700	55	0.083
t cell differentiation	GO:0030217	6	0.082
regulation of transcription from rna polymerase ii promoter	GO:0006357	114	0.082	Mouse
response to external stimulus	GO:0009605	264	0.082
regulation of cell adhesion	GO:0030155	15	0.081
heart looping	GO:0001947	94	0.081
negative regulation of macromolecule biosynthetic process	GO:0010558	48	0.080	Mouse
negative regulation of rna metabolic process	GO:0051253	48	0.080	Mouse
response to other organism	GO:0051707	97	0.080
organelle organization	GO:0006996	227	0.079
negative regulation of nucleic acid templated transcription	GO:1903507	45	0.079	Mouse
cellular response to oxygen radical	GO:0071450	2	0.078
morphogenesis of an epithelium	GO:0002009	333	0.078
axon development	GO:0061564	166	0.076
maintenance of location	GO:0051235	4	0.076
apoptotic process involved in development	GO:1902742	2	0.075
embryonic heart tube morphogenesis	GO:0003143	108	0.075
determination of left right symmetry	GO:0007368	179	0.074
negative regulation of rna biosynthetic process	GO:1902679	45	0.073	Mouse
lymph vessel development	GO:0001945	27	0.073
removal of superoxide radicals	GO:0019430	2	0.073
cellular localization	GO:0051641	97	0.072
regulation of protein phosphorylation	GO:0001932	18	0.072
regulation of localization	GO:0032879	104	0.072
regulation of cysteine type endopeptidase activity involved in apoptotic process	GO:0043281	20	0.071
signal transduction	GO:0007165	455	0.070
positive regulation of nitrogen compound metabolic process	GO:0051173	69	0.070	Mouse
lymphocyte homeostasis	GO:0002260	1	0.069
positive regulation of transport	GO:0051050	2	0.068
regulation of cell motility	GO:2000145	46	0.068
protein metabolic process	GO:0019538	183	0.067
auditory receptor cell fate determination	GO:0042668	2	0.067
negative regulation of cell differentiation	GO:0045596	46	0.066
single organism organelle organization	GO:1902589	199	0.066
neurotransmitter secretion	GO:0007269	2	0.066
cell activation	GO:0001775	16	0.066
stem cell development	GO:0048864	82	0.064
endocrine system development	GO:0035270	65	0.064
positive regulation of macromolecule metabolic process	GO:0010604	93	0.061	Mouse
positive regulation of neuron migration	GO:2001224	2	0.061
programmed cell death	GO:0012501	119	0.060
superoxide metabolic process	GO:0006801	2	0.060
cellular amino acid metabolic process	GO:0006520	7	0.059
mechanoreceptor differentiation	GO:0042490	37	0.059
sensory organ development	GO:0007423	393	0.059	Mouse
dna alkylation	GO:0006305	8	0.058
regulation of cellular ketone metabolic process	GO:0010565	7	0.058
intracellular estrogen receptor signaling pathway	GO:0030520	3	0.058
cellular response to cytokine stimulus	GO:0071345	7	0.058
regulation of rna metabolic process	GO:0051252	224	0.057	Mouse
positive regulation of cellular process	GO:0048522	201	0.057	Mouse
production of molecular mediator of immune response	GO:0002440	2	0.057
blood vessel morphogenesis	GO:0048514	216	0.057
sensory perception of chemical stimulus	GO:0007606	3	0.056
positive regulation of secretion by cell	GO:1903532	1	0.056
positive regulation of map kinase activity	GO:0043406	3	0.055
antimicrobial humoral response	GO:0019730	2	0.055
protein complex assembly	GO:0006461	30	0.054
regulation of molecular function	GO:0065009	70	0.054
regulation of transcription dna templated	GO:0006355	213	0.054	Mouse
cell substrate adhesion	GO:0031589	4	0.054
auditory receptor cell fate commitment	GO:0009912	4	0.053
regulation of dendrite development	GO:0050773	3	0.053
positive regulation of apoptotic process	GO:0043065	29	0.053
negative regulation of programmed cell death	GO:0043069	58	0.053
positive regulation of immune response	GO:0050778	11	0.053
positive regulation of signal transduction	GO:0009967	56	0.053
regulation of organelle organization	GO:0033043	29	0.052
negative regulation of apoptotic process	GO:0043066	55	0.051
regulation of catalytic activity	GO:0050790	55	0.051
fin morphogenesis	GO:0033334	53	0.051
negative regulation of cellular metabolic process	GO:0031324	77	0.051	Mouse
regulation of actin cytoskeleton organization	GO:0032956	8	0.050
positive regulation of endothelial cell proliferation	GO:0001938	1	0.050
blood circulation	GO:0008015	87	0.050
g2 m transition of mitotic cell cycle	GO:0000086	4	0.050
regulation of cellular protein metabolic process	GO:0032268	52	0.050
positive regulation of signaling	GO:0023056	56	0.050
transport	GO:0006810	220	0.050
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	48	0.050	Mouse
spindle assembly	GO:0051225	2	0.049
collagen metabolic process	GO:0032963	2	0.049
organelle assembly	GO:0070925	110	0.049
anatomical structure homeostasis	GO:0060249	36	0.048
nucleobase containing compound biosynthetic process	GO:0034654	205	0.048	Mouse
extrinsic apoptotic signaling pathway in absence of ligand	GO:0097192	1	0.048
regulation of endopeptidase activity	GO:0052548	23	0.047
positive regulation of peptidyl tyrosine phosphorylation	GO:0050731	1	0.046
positive regulation of stem cell proliferation	GO:2000648	1	0.046
heart morphogenesis	GO:0003007	156	0.046
cell fate commitment	GO:0045165	99	0.045
negative regulation of cell death	GO:0060548	60	0.044
cellular response to chemical stimulus	GO:0070887	157	0.044
negative regulation of histone modification	GO:0031057	1	0.044
regulation of extrinsic apoptotic signaling pathway in absence of ligand	GO:2001239	1	0.044
regulation of cell morphogenesis	GO:0022604	42	0.044
cell cycle g2 m phase transition	GO:0044839	4	0.043
post embryonic foregut morphogenesis	GO:0048618	3	0.043
protein complex biogenesis	GO:0070271	30	0.043
positive regulation of cellular component biogenesis	GO:0044089	3	0.043
inositol lipid mediated signaling	GO:0048017	2	0.042
transcription from rna polymerase ii promoter	GO:0006366	80	0.042	Mouse
embryonic heart tube formation	GO:0003144	1	0.042
immune response regulating signaling pathway	GO:0002764	5	0.042
intracellular signal transduction	GO:0035556	85	0.042
cellular amide metabolic process	GO:0043603	4	0.041
positive regulation of immune effector process	GO:0002699	3	0.041
modification dependent macromolecule catabolic process	GO:0043632	3	0.041
regulation of neurotransmitter secretion	GO:0046928	1	0.041
biological adhesion	GO:0022610	40	0.041
neuron projection guidance	GO:0097485	86	0.041
proepicardium development	GO:0003342	4	0.041
negative regulation of response to stimulus	GO:0048585	104	0.041
positive regulation of secretion	GO:0051047	1	0.041
regulation of ectoderm development	GO:2000383	2	0.041
cellular protein modification process	GO:0006464	100	0.040
cell proliferation	GO:0008283	80	0.040
eye morphogenesis	GO:0048592	144	0.040
cardiogenic plate morphogenesis	GO:0003142	1	0.040
regulation of hydrogen peroxide metabolic process	GO:0010310	1	0.040
positive regulation of jak stat cascade	GO:0046427	2	0.039
vasculogenesis	GO:0001570	41	0.039
regulation of wound healing	GO:0061041	2	0.039
regulation of tyrosine phosphorylation of stat protein	GO:0042509	1	0.038
leukocyte proliferation	GO:0070661	1	0.038
taxis	GO:0042330	109	0.038
neuron projection development	GO:0031175	180	0.038
regulation of signal transduction	GO:0009966	225	0.038
protein secretion	GO:0009306	1	0.038
regulation of inflammatory response	GO:0050727	2	0.038
behavior	GO:0007610	74	0.038
organelle localization	GO:0051640	49	0.037
defense response to fungus	GO:0050832	2	0.037
retina development in camera type eye	GO:0060041	146	0.037	Mouse
microtubule cytoskeleton organization involved in mitosis	GO:1902850	1	0.036
positive regulation of endopeptidase activity	GO:0010950	10	0.036
skeletal muscle tissue development	GO:0007519	67	0.036
positive regulation of macromolecule biosynthetic process	GO:0010557	59	0.036	Mouse
response to oxidative stress	GO:0006979	11	0.036
positive regulation of cell differentiation	GO:0045597	30	0.036	Mouse
positive regulation of metabolic process	GO:0009893	108	0.036	Mouse
cell part morphogenesis	GO:0032990	246	0.036
regulation of histone h3 k9 methylation	GO:0051570	2	0.035
nucleobase containing compound metabolic process	GO:0006139	274	0.035	Mouse
single organism metabolic process	GO:0044710	217	0.035
motor neuron axon guidance	GO:0008045	23	0.035
regulation of cysteine type endopeptidase activity	GO:2000116	21	0.035
positive regulation of response to wounding	GO:1903036	5	0.035
muscle tissue development	GO:0060537	110	0.034
lymph vessel morphogenesis	GO:0036303	25	0.034
internal protein amino acid acetylation	GO:0006475	2	0.034
cytosolic calcium ion transport	GO:0060401	3	0.034
nucleic acid templated transcription	GO:0097659	181	0.034	Mouse
response to retinoic acid	GO:0032526	6	0.034
cellular component assembly involved in morphogenesis	GO:0010927	107	0.034
regulation of transcription from rna polymerase iii promoter	GO:0006359	1	0.033
zymogen activation	GO:0031638	3	0.033
regulation of response to cytokine stimulus	GO:0060759	3	0.033
regulation of cytoskeleton organization	GO:0051493	11	0.033
regulation of tissue remodeling	GO:0034103	2	0.033
peptidyl tyrosine modification	GO:0018212	5	0.032
regulation of locomotion	GO:0040012	55	0.032
system process	GO:0003008	185	0.032
epithelial cell morphogenesis	GO:0003382	2	0.032
tissue homeostasis	GO:0001894	25	0.032
response to stress	GO:0006950	263	0.031
regulation of protein targeting	GO:1903533	2	0.031
regulation of cytoplasmic transport	GO:1903649	4	0.031
positive regulation of cellular catabolic process	GO:0031331	3	0.031
b cell activation	GO:0042113	2	0.031
histone h3 k9 methylation	GO:0051567	5	0.031
positive regulation of endothelial cell differentiation	GO:0045603	2	0.031
appendage development	GO:0048736	80	0.031
cellular protein catabolic process	GO:0044257	4	0.031
determination of intestine left right asymmetry	GO:0071908	2	0.030
regulation of protein complex assembly	GO:0043254	3	0.030
mitotic cell cycle process	GO:1903047	48	0.030
positive regulation of molecular function	GO:0044093	33	0.030
protein import	GO:0017038	3	0.030
negative regulation of nucleobase containing compound metabolic process	GO:0045934	59	0.029	Mouse
negative regulation of sequence specific dna binding transcription factor activity	GO:0043433	2	0.029
single organism membrane organization	GO:0044802	20	0.029
regulation of nucleocytoplasmic transport	GO:0046822	2	0.029
developmental programmed cell death	GO:0010623	4	0.029
heart valve formation	GO:0003188	4	0.029
myeloid cell development	GO:0061515	32	0.028
cardiac atrium morphogenesis	GO:0003209	2	0.028
peptide metabolic process	GO:0006518	1	0.028
positive regulation of catabolic process	GO:0009896	4	0.028
fin development	GO:0033333	77	0.028
chordate embryonic development	GO:0043009	271	0.028
positive regulation of epithelial cell proliferation	GO:0050679	1	0.028
response to hydrogen peroxide	GO:0042542	3	0.028
mitotic cell cycle	GO:0000278	64	0.028
aging	GO:0007568	2	0.027
response to wounding	GO:0009611	116	0.027
astrocyte differentiation	GO:0048708	1	0.027
proteasomal protein catabolic process	GO:0010498	2	0.027
neuron projection morphogenesis	GO:0048812	161	0.027
defense response to other organism	GO:0098542	33	0.027
protein localization	GO:0008104	40	0.027
establishment of localization	GO:0051234	244	0.027
epidermal cell differentiation	GO:0009913	36	0.027
epithelial cell development	GO:0002064	42	0.027
muscle cell differentiation	GO:0042692	139	0.027
positive regulation of stress activated protein kinase signaling cascade	GO:0070304	3	0.027
regulation of cell cycle g2 m phase transition	GO:1902749	4	0.027
regulation of biomineral tissue development	GO:0070167	2	0.026
epithelial tube morphogenesis	GO:0060562	148	0.026
organic acid metabolic process	GO:0006082	31	0.026
establishment of organelle localization	GO:0051656	45	0.026
regulation of mononuclear cell migration	GO:0071675	1	0.026
myotube differentiation	GO:0014902	45	0.026
g1 s transition of mitotic cell cycle	GO:0000082	1	0.026
mesenchymal cell proliferation	GO:0010463	1	0.026
organelle fusion	GO:0048284	3	0.026
positive regulation of response to stimulus	GO:0048584	80	0.026
regulation of endothelial cell proliferation	GO:0001936	1	0.026
regulation of dna methylation	GO:0044030	5	0.026
spindle assembly involved in mitosis	GO:0090307	1	0.026
positive regulation of cell cycle	GO:0045787	3	0.026
nuclear import	GO:0051170	3	0.026
regulation of retina development in camera type eye	GO:1902866	2	0.026
negative regulation of erythrocyte differentiation	GO:0045647	1	0.026
positive regulation of leukocyte differentiation	GO:1902107	1	0.025	Mouse
positive regulation of hydrolase activity	GO:0051345	13	0.025
single organism cell adhesion	GO:0098602	29	0.025
epithelial cell proliferation	GO:0050673	17	0.025
phosphorylation	GO:0016310	69	0.025
phosphate containing compound metabolic process	GO:0006796	108	0.025
regulation of peptidase activity	GO:0052547	23	0.025
somatic stem cell maintenance	GO:0035019	1	0.025
extrinsic apoptotic signaling pathway	GO:0097191	3	0.025
regulation of mesenchymal cell proliferation	GO:0010464	1	0.024
regulation of sequestering of calcium ion	GO:0051282	4	0.024
cellular response to reactive oxygen species	GO:0034614	2	0.024
leukocyte migration	GO:0050900	15	0.024
mononuclear cell proliferation	GO:0032943	1	0.024
negative regulation of transcription dna templated	GO:0045892	45	0.024	Mouse
regulation of production of molecular mediator of immune response	GO:0002700	1	0.024
cell migration to the midline involved in heart development	GO:0003318	12	0.024
regulation of cellular component biogenesis	GO:0044087	12	0.024
muscle cell development	GO:0055001	115	0.024
axonogenesis	GO:0007409	152	0.024
response to cytokine	GO:0034097	7	0.024
regulation of protein modification process	GO:0031399	29	0.024
regulation of neurogenesis	GO:0050767	87	0.024
guanosine containing compound metabolic process	GO:1901068	4	0.024
monocyte differentiation	GO:0030224	2	0.024
proteasome mediated ubiquitin dependent protein catabolic process	GO:0043161	2	0.024
muscle organ development	GO:0007517	101	0.023
osteoclast development	GO:0036035	1	0.023
regulation of myotube differentiation	GO:0010830	2	0.023
homeostasis of number of cells within a tissue	GO:0048873	4	0.023
proteolysis	GO:0006508	38	0.023
stem cell division	GO:0017145	1	0.023
negative regulation of epithelial cell migration	GO:0010633	1	0.023
lymphatic endothelial cell fate commitment	GO:0060838	1	0.023
neuron migration	GO:0001764	22	0.023
positive regulation of tyrosine phosphorylation of stat3 protein	GO:0042517	1	0.022
negative regulation of signal transduction	GO:0009968	94	0.022
regulation of calcium ion transport	GO:0051924	2	0.022
regulation of immune response	GO:0050776	14	0.022
atrioventricular valve formation	GO:0003190	3	0.022
dna metabolic process	GO:0006259	27	0.022
embryonic organ morphogenesis	GO:0048562	274	0.022
negative regulation of transcription from rna polymerase ii promoter	GO:0000122	16	0.022	Mouse
negative regulation of leukocyte differentiation	GO:1902106	1	0.022
cognition	GO:0050890	1	0.022
skeletal system development	GO:0001501	181	0.022
negative regulation of mesodermal cell fate specification	GO:0042662	3	0.022
response to external biotic stimulus	GO:0043207	97	0.022
regulation of protein transport	GO:0051223	3	0.022
non canonical wnt signaling pathway	GO:0035567	13	0.022
endothelial cell proliferation	GO:0001935	11	0.022
regulation of proteolysis	GO:0030162	24	0.022
regulation of cellular component movement	GO:0051270	55	0.022
regulation of carbohydrate metabolic process	GO:0006109	4	0.021
negative regulation of cellular component organization	GO:0051129	16	0.021
reactive oxygen species metabolic process	GO:0072593	6	0.021
embryonic pattern specification	GO:0009880	44	0.021
foregut morphogenesis	GO:0007440	4	0.021
multicellular organismal macromolecule metabolic process	GO:0044259	2	0.021
positive regulation of macrophage chemotaxis	GO:0010759	1	0.021
granulocyte migration	GO:0097530	11	0.021
negative regulation of cytokine production	GO:0001818	1	0.021
reactive oxygen species biosynthetic process	GO:1903409	1	0.021
phosphorus metabolic process	GO:0006793	109	0.021
positive regulation of catalytic activity	GO:0043085	25	0.021
t cell activation	GO:0042110	6	0.020
formation of primary germ layer	GO:0001704	62	0.020
dicarboxylic acid transport	GO:0006835	1	0.020
transcription from rna polymerase iii promoter	GO:0006383	1	0.020
dorsal aorta development	GO:0035907	4	0.020
regulation of cytokine mediated signaling pathway	GO:0001959	3	0.020

ikzf1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.061
cardiovascular system disease	DOID:1287	0.061
disease of cellular proliferation	DOID:14566	0.048
cancer	DOID:162	0.048
organ system cancer	DOID:0050686	0.030

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