IMP: Integrative Multi-species Prediction

Danio rerio

40 known processes

creb1

cAMP responsive element binding protein 1

(Aliases: MGC55598,zgc:55598)

Ensembl: ENSDARG00000053586
ZFIN: ZDB-GENE-040426-750
Entrez: 573207
UniProtKB: Q803K8

Process Predictions
Disease Predictions

creb1 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability
neuron differentiation	GO:0030182	353	0.336
cellular macromolecule metabolic process	GO:0044260	391	0.297
negative regulation of biological process	GO:0048519	304	0.257
head development	GO:0060322	303	0.253
regulation of nitrogen compound metabolic process	GO:0051171	251	0.216
regulation of cellular macromolecule biosynthetic process	GO:2000112	222	0.201
positive regulation of biological process	GO:0048518	253	0.197
nucleic acid templated transcription	GO:0097659	181	0.192
regulation of gene expression	GO:0010468	265	0.191
generation of neurons	GO:0048699	385	0.188
cell projection morphogenesis	GO:0048858	244	0.184
nucleobase containing compound metabolic process	GO:0006139	274	0.154
neuron development	GO:0048666	262	0.151
nitrogen compound metabolic process	GO:0006807	319	0.144
locomotion	GO:0040011	313	0.142
regulation of nucleobase containing compound metabolic process	GO:0019219	250	0.140
transcription dna templated	GO:0006351	181	0.129
macromolecule biosynthetic process	GO:0009059	227	0.126
rna metabolic process	GO:0016070	219	0.125
cellular macromolecule biosynthetic process	GO:0034645	224	0.123
regulation of biosynthetic process	GO:0009889	250	0.122
organic substance biosynthetic process	GO:1901576	289	0.119
neuroblast proliferation	GO:0007405	2	0.118
cell projection organization	GO:0030030	284	0.114
heterocycle biosynthetic process	GO:0018130	215	0.111
regulation of multicellular organismal process	GO:0051239	277	0.111
cellular aromatic compound metabolic process	GO:0006725	295	0.107
signal transduction	GO:0007165	455	0.104
rna biosynthetic process	GO:0032774	181	0.103
cellular component morphogenesis	GO:0032989	336	0.101
organic cyclic compound metabolic process	GO:1901360	301	0.099
biosynthetic process	GO:0009058	294	0.094
immune system process	GO:0002376	241	0.091
single organism transport	GO:0044765	206	0.090
single organism localization	GO:1902578	225	0.088
regulation of macromolecule metabolic process	GO:0060255	317	0.087
positive regulation of cell cycle	GO:0045787	3	0.083
cellular protein metabolic process	GO:0044267	129	0.082
cellular nitrogen compound metabolic process	GO:0034641	290	0.081
stem cell proliferation	GO:0072089	4	0.081
neuron projection morphogenesis	GO:0048812	161	0.081
embryo development ending in birth or egg hatching	GO:0009792	271	0.080
larval development	GO:0002164	2	0.077
central nervous system development	GO:0007417	387	0.076
cellular nitrogen compound biosynthetic process	GO:0044271	218	0.076
cell morphogenesis	GO:0000902	289	0.075
regulation of primary metabolic process	GO:0080090	311	0.072
negative regulation of cellular process	GO:0048523	283	0.071
organelle organization	GO:0006996	227	0.071
cellular amine metabolic process	GO:0044106	2	0.070
epidermis development	GO:0008544	48	0.069
regulation of metabolic process	GO:0019222	359	0.068
regulation of response to stimulus	GO:0048583	269	0.067
gene expression	GO:0010467	252	0.067
regulation of nucleic acid templated transcription	GO:1903506	213	0.066
cell morphogenesis involved in differentiation	GO:0000904	195	0.065
nucleobase containing compound biosynthetic process	GO:0034654	205	0.063
regulation of cellular metabolic process	GO:0031323	320	0.063
positive regulation of nitrogen compound metabolic process	GO:0051173	69	0.062
amine metabolic process	GO:0009308	2	0.062
regulation of rna biosynthetic process	GO:2001141	213	0.060
regulation of rna metabolic process	GO:0051252	224	0.060
single organism metabolic process	GO:0044710	217	0.059
aromatic compound biosynthetic process	GO:0019438	217	0.058
apoptotic process	GO:0006915	116	0.056
digestive tract development	GO:0048565	265	0.056
stem cell maintenance	GO:0019827	4	0.055
heterocycle metabolic process	GO:0046483	290	0.055
meiotic cell cycle process	GO:1903046	3	0.054
nucleic acid metabolic process	GO:0090304	244	0.054
regulation of transcription dna templated	GO:0006355	213	0.052
camera type eye development	GO:0043010	222	0.052
cellular component assembly	GO:0022607	170	0.052
regulation of macromolecule biosynthetic process	GO:0010556	225	0.051
cell part morphogenesis	GO:0032990	246	0.050
regulation of nervous system development	GO:0051960	90	0.050
cellular protein catabolic process	GO:0044257	4	0.049
regulation of cellular amine metabolic process	GO:0033238	0	0.049
establishment of localization	GO:0051234	244	0.048
regulation of apoptotic process	GO:0042981	98	0.047
negative regulation of nitrogen compound metabolic process	GO:0051172	59	0.047
regulation of cell communication	GO:0010646	232	0.045
cell death	GO:0008219	121	0.045
regulation of stem cell proliferation	GO:0072091	2	0.045
positive regulation of metabolic process	GO:0009893	108	0.043
neural retina development	GO:0003407	49	0.042
death	GO:0016265	121	0.042
behavior	GO:0007610	74	0.040
positive regulation of cellular metabolic process	GO:0031325	94	0.040
gabaergic neuron differentiation	GO:0097154	2	0.040
cellular amino acid metabolic process	GO:0006520	7	0.040
regulation of reproductive process	GO:2000241	4	0.039
regulation of biological quality	GO:0065008	263	0.039
programmed cell death	GO:0012501	119	0.039
regulation of cellular amino acid metabolic process	GO:0006521	0	0.038
intracellular signal transduction	GO:0035556	85	0.038
single organism organelle organization	GO:1902589	199	0.037
regulation of mechanoreceptor differentiation	GO:0045631	1	0.036
negative regulation of metabolic process	GO:0009892	86	0.036
neuron projection development	GO:0031175	180	0.036
regulation of cellular biosynthetic process	GO:0031326	245	0.035
small molecule metabolic process	GO:0044281	77	0.035
meiotic nuclear division	GO:0007126	4	0.035
regulation of protein complex assembly	GO:0043254	3	0.035
positive regulation of cellular process	GO:0048522	201	0.035
epithelial cell differentiation	GO:0030855	116	0.033
regulation of metal ion transport	GO:0010959	4	0.033
regulation of neuron differentiation	GO:0045664	56	0.032
regulation of signal transduction	GO:0009966	225	0.032
blood vessel morphogenesis	GO:0048514	216	0.032
protein complex assembly	GO:0006461	30	0.031
adult behavior	GO:0030534	2	0.030
macromolecule modification	GO:0043412	111	0.030
regulation of receptor activity	GO:0010469	2	0.030
proteolysis involved in cellular protein catabolic process	GO:0051603	3	0.030
positive regulation of rna biosynthetic process	GO:1902680	57	0.030
positive regulation of cellular biosynthetic process	GO:0031328	68	0.029
cellular pigmentation	GO:0033059	30	0.029
protein modification process	GO:0036211	100	0.029
muscle structure development	GO:0061061	196	0.028
gtp metabolic process	GO:0046039	4	0.028
eye morphogenesis	GO:0048592	144	0.028
vasculature development	GO:0001944	278	0.028
retina morphogenesis in camera type eye	GO:0060042	79	0.028
heart contraction	GO:0060047	71	0.027
transport	GO:0006810	220	0.027
maintenance of location	GO:0051235	4	0.027
regulation of mrna splicing via spliceosome	GO:0048024	3	0.026
response to stress	GO:0006950	263	0.026
guanosine containing compound metabolic process	GO:1901068	4	0.026
cell cycle	GO:0007049	93	0.026
eye development	GO:0001654	277	0.026
regulation of signaling	GO:0023051	235	0.026
cellular biosynthetic process	GO:0044249	286	0.026
establishment of protein localization to organelle	GO:0072594	4	0.025
cell morphogenesis involved in neuron differentiation	GO:0048667	163	0.025
cellular protein modification process	GO:0006464	100	0.025
dendrite morphogenesis	GO:0048813	5	0.025
regulation of nucleoside metabolic process	GO:0009118	2	0.025
sensory organ development	GO:0007423	393	0.025
digestive system development	GO:0055123	289	0.025
cellular component movement	GO:0006928	335	0.025
positive regulation of gene expression	GO:0010628	71	0.024
response to wounding	GO:0009611	116	0.024
positive regulation of cell proliferation	GO:0008284	15	0.024
central nervous system neuron differentiation	GO:0021953	74	0.024
regulation of gtp catabolic process	GO:0033124	2	0.024
exocrine pancreas development	GO:0031017	28	0.024
erythrocyte differentiation	GO:0030218	54	0.024
positive regulation of catabolic process	GO:0009896	4	0.023
camera type eye morphogenesis	GO:0048593	108	0.023
muscle organ development	GO:0007517	101	0.023
protein localization to nucleus	GO:0034504	3	0.023
positive regulation of stem cell proliferation	GO:2000648	1	0.022
catechol containing compound biosynthetic process	GO:0009713	2	0.022
negative regulation of cellular metabolic process	GO:0031324	77	0.022
regulation of developmental process	GO:0050793	247	0.022
regulation of purine nucleotide catabolic process	GO:0033121	2	0.022
macromolecular complex subunit organization	GO:0043933	74	0.022
tube closure	GO:0060606	1	0.022
nuclear import	GO:0051170	3	0.022
response to drug	GO:0042493	3	0.022
organic cyclic compound biosynthetic process	GO:1901362	223	0.022
negative regulation of macromolecule metabolic process	GO:0010605	76	0.021
regulation of programmed cell death	GO:0043067	101	0.021
blood vessel development	GO:0001568	246	0.021
regulation of transcription from rna polymerase ii promoter	GO:0006357	114	0.021
positive regulation of transport	GO:0051050	2	0.021
proteasome mediated ubiquitin dependent protein catabolic process	GO:0043161	2	0.021
brain development	GO:0007420	293	0.021
regulation of nucleotide catabolic process	GO:0030811	2	0.021
phagocytosis	GO:0006909	3	0.021
response to chemical	GO:0042221	320	0.021
macromolecular complex assembly	GO:0065003	35	0.021
regulation of cytokine production	GO:0001817	3	0.020
positive regulation of mesenchymal cell proliferation	GO:0002053	1	0.020
protein complex biogenesis	GO:0070271	30	0.020
positive regulation of nucleic acid templated transcription	GO:1903508	57	0.019
positive regulation of apoptotic signaling pathway	GO:2001235	1	0.019
hematopoietic or lymphoid organ development	GO:0048534	191	0.019
retina development in camera type eye	GO:0060041	146	0.019
mitotic sister chromatid cohesion	GO:0007064	2	0.019
aorta development	GO:0035904	4	0.019
positive regulation of rna metabolic process	GO:0051254	59	0.018
spinal cord radial glial cell differentiation	GO:0021531	2	0.018
regulation of fatty acid metabolic process	GO:0019217	1	0.018
gtp catabolic process	GO:0006184	2	0.018
positive regulation of transcription dna templated	GO:0045893	57	0.018
system process	GO:0003008	185	0.018
positive regulation of cellular amine metabolic process	GO:0033240	0	0.018
mitochondrion organization	GO:0007005	4	0.018
phagocytosis engulfment	GO:0006911	1	0.018
microtubule cytoskeleton organization	GO:0000226	33	0.018
dendrite development	GO:0016358	9	0.018
negative regulation of programmed cell death	GO:0043069	58	0.018
carboxylic acid metabolic process	GO:0019752	22	0.017
regulation of cellular ketone metabolic process	GO:0010565	7	0.017
nucleocytoplasmic transport	GO:0006913	4	0.017
neuron fate determination	GO:0048664	2	0.017
response to biotic stimulus	GO:0009607	97	0.017
cell projection assembly	GO:0030031	64	0.017
regulation of cell death	GO:0010941	103	0.017
negative regulation of cytokine production	GO:0001818	1	0.017
regulation of dendrite development	GO:0050773	3	0.017
cellular response to extracellular stimulus	GO:0031668	2	0.016
protein stabilization	GO:0050821	2	0.016
negative regulation of signaling	GO:0023057	96	0.016
regulation of epithelial cell proliferation	GO:0050678	3	0.016
positive regulation of macromolecule biosynthetic process	GO:0010557	59	0.016
positive regulation of cellular component biogenesis	GO:0044089	3	0.016
regulation of inner ear receptor cell differentiation	GO:2000980	1	0.016
cellular component biogenesis	GO:0044085	178	0.016
regulation of anatomical structure morphogenesis	GO:0022603	130	0.016
retina layer formation	GO:0010842	24	0.016
response to hormone	GO:0009725	48	0.015
negative regulation of protein phosphorylation	GO:0001933	4	0.015
response to organic substance	GO:0010033	153	0.015
chromosome organization	GO:0051276	31	0.015
regulation of gene silencing	GO:0060968	1	0.015
proepicardium development	GO:0003342	4	0.015
oxoacid metabolic process	GO:0043436	31	0.015
cell cycle process	GO:0022402	53	0.015
negative regulation of gene expression	GO:0010629	65	0.015
digestive tract morphogenesis	GO:0048546	231	0.015
forebrain regionalization	GO:0021871	4	0.014
pancreas development	GO:0031016	84	0.014
organic acid metabolic process	GO:0006082	31	0.014
locomotory behavior	GO:0007626	34	0.014
negative regulation of dna metabolic process	GO:0051053	4	0.014
positive regulation of nucleotide catabolic process	GO:0030813	1	0.014
regulation of multicellular organismal development	GO:2000026	223	0.014
meiosis i	GO:0007127	1	0.014
radial glial cell differentiation	GO:0060019	2	0.014
cell migration	GO:0016477	237	0.014
protein metabolic process	GO:0019538	183	0.014
cell motility	GO:0048870	244	0.014
positive regulation of macromolecule metabolic process	GO:0010604	93	0.014
negative regulation of rna biosynthetic process	GO:1902679	45	0.014
regulation of protein metabolic process	GO:0051246	56	0.014
embryonic organ development	GO:0048568	381	0.014
embryonic cranial skeleton morphogenesis	GO:0048701	90	0.014
nuclear transport	GO:0051169	4	0.014
skin development	GO:0043588	54	0.013
regulation of molecular function	GO:0065009	70	0.013
modification dependent macromolecule catabolic process	GO:0043632	3	0.013
central nervous system neuron axonogenesis	GO:0021955	18	0.013
reproduction	GO:0000003	40	0.013
aging	GO:0007568	2	0.013
regulation of gtpase activity	GO:0043087	2	0.013
sex determination	GO:0007530	1	0.013
peptide transport	GO:0015833	1	0.013
epidermal cell fate specification	GO:0009957	4	0.013
regulation of cell activation	GO:0050865	1	0.013
cellular component maintenance	GO:0043954	3	0.013
positive regulation of nucleobase containing compound metabolic process	GO:0045935	69	0.013
protein complex subunit organization	GO:0071822	46	0.013
primary neural tube formation	GO:0014020	1	0.012
modification dependent protein catabolic process	GO:0019941	3	0.012
proteasomal protein catabolic process	GO:0010498	2	0.012
positive regulation of translation	GO:0045727	1	0.012
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	GO:0002460	4	0.012
positive regulation of nucleoside metabolic process	GO:0045979	1	0.012
chordate embryonic development	GO:0043009	271	0.012
response to abiotic stimulus	GO:0009628	122	0.012
negative regulation of nucleobase containing compound metabolic process	GO:0045934	59	0.012
positive regulation of cellular amino acid metabolic process	GO:0045764	0	0.012
negative regulation of biosynthetic process	GO:0009890	55	0.012
cell junction maintenance	GO:0034331	2	0.012
negative regulation of cellular biosynthetic process	GO:0031327	55	0.012
protein dephosphorylation	GO:0006470	3	0.012
guanosine containing compound catabolic process	GO:1901069	2	0.012
regulation of jak stat cascade	GO:0046425	3	0.012
endocardium morphogenesis	GO:0003160	4	0.012
response to glucose	GO:0009749	3	0.012
epithelial tube morphogenesis	GO:0060562	148	0.012
negative regulation of kinase activity	GO:0033673	4	0.011
positive regulation of cellular catabolic process	GO:0031331	3	0.011
peptidyl lysine acetylation	GO:0018394	2	0.011
protein localization	GO:0008104	40	0.011
regulation of hematopoietic progenitor cell differentiation	GO:1901532	1	0.011
protein targeting to nucleus	GO:0044744	3	0.011
regulation of gene expression epigenetic	GO:0040029	11	0.011
positive regulation of biosynthetic process	GO:0009891	68	0.011
membrane invagination	GO:0010324	1	0.011
regulation of endothelial cell differentiation	GO:0045601	3	0.011
carbohydrate homeostasis	GO:0033500	1	0.011
hemopoiesis	GO:0030097	183	0.011
multicellular organism growth	GO:0035264	4	0.011
response to monosaccharide	GO:0034284	3	0.011
cellular response to external stimulus	GO:0071496	2	0.011
positive regulation of purine nucleotide catabolic process	GO:0033123	1	0.011
protein import	GO:0017038	3	0.011
positive regulation of epithelial cell proliferation	GO:0050679	1	0.011
stem cell division	GO:0017145	1	0.011
regulation of dendrite morphogenesis	GO:0048814	3	0.011
gland development	GO:0048732	143	0.011
central nervous system projection neuron axonogenesis	GO:0021952	15	0.011
positive regulation of response to stimulus	GO:0048584	80	0.011
transcription from rna polymerase ii promoter	GO:0006366	80	0.010
protein acylation	GO:0043543	3	0.010
protein import into nucleus	GO:0006606	3	0.010
axon development	GO:0061564	166	0.010
gastrulation	GO:0007369	208	0.010
regulation of cellular protein metabolic process	GO:0032268	52	0.010
positive regulation of cyclin dependent protein serine threonine kinase activity	GO:0045737	1	0.010
negative regulation of catabolic process	GO:0009895	3	0.010
multi organism reproductive process	GO:0044703	36	0.010
catabolic process	GO:0009056	32	0.010
myeloid cell homeostasis	GO:0002262	56	0.010
regulation of cellular component organization	GO:0051128	86	0.010
positive regulation of gtpase activity	GO:0043547	1	0.010
pancreatic a cell development	GO:0003322	2	0.010
regulation of stem cell differentiation	GO:2000736	4	0.010
protein acetylation	GO:0006473	2	0.010
epidermal cell differentiation	GO:0009913	36	0.010
wound healing	GO:0042060	90	0.010
protein modification by small protein removal	GO:0070646	1	0.010
septum transversum development	GO:0003343	4	0.010
morphogenesis of an epithelium	GO:0002009	333	0.010

creb1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

	Disease	DO term ID	Size	Probability	Func Analog Org
	disease of cellular proliferation	DOID:14566	0	0.015

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